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Monomethyl Fumarate GPR agonist

Name: Monomethyl Fumarate
Brand: Selleck Chemicals
SKU: S6889
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S6889

Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. This compound prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Chemical Structure

Molecular Weight: 130.10

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Quality Control

Batch: Purity: 99.59%

99.59

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other GPR Inhibitors	ONC212 Fasiglifam(TAK-875) Hemihydrate GW9508 3-chloro-5-hydroxybenzoic Acid AH7614 TC-G-1008 (GPR39-C3) JMS-17-2 NE 52-QQ57 SNAP94847 hydrochloride AZD1981

Solubility

In vitro
Batch:

DMSO : 26 mg/mL (199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 26 mg/mL

Water : 20 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.3mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 26 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.18mg/ml (1.38mM)	Taking the 1 mL working solution as an example, add 50 μL of 3.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	130.10	Formula	C₅H₆O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2756-87-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate			SMILES	COC(=O)\C=C\C(O)=O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	GPR109A
References	[1] https://pubmed.ncbi.nlm.nih.gov/18722346/ [2] https://pubmed.ncbi.nlm.nih.gov/31344443/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-09-30)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07198659	RECRUITING	Unresectable Pancreatic Cancer	The First Affiliated Hospital of Air Force Medicial University	2025-07-14	EARLY_PHASE1
NCT03500328	ACTIVE_NOT_RECRUITING	Multiple Sclerosis, Relapsing-Remitting	Johns Hopkins University	2018-05-02
NCT06014658	RECRUITING	Cancer	MBrace Therapeutics	2023-11-07	PHASE1; PHASE2
NCT03449251	UNKNOWN	Cardiovascular Diseases; Type 2 Diabetes Mellitus	Cambridge University Hospitals NHS Foundation Trust	2018-03-28	PHASE2
NCT05755048	UNKNOWN	Breast Cancer	Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.	2023-03-28	PHASE3
NCT05858970	Not yet recruiting	Optical Biopsy\|Colonic Dysplasia\|Diagnostic Accuracy	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2024-04-01	--

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