Demethyl-Coclaurine

Catalog No.S3294 Synonyms: Higenamine, Norcoclaurine

For research use only.

Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.

Demethyl-Coclaurine Chemical Structure

CAS No. 5843-65-2

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Biological Activity

Description Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.
Targets
β2-AR [1] Akt [1] PI3K [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 271.31
Formula

C16H17NO3

CAS No. 5843-65-2
Storage 3 years -20°C powder
2 years -80°C in solvent

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