Demethyl-Coclaurine

Synonyms: Higenamine, Norcoclaurine

Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.

Demethyl-Coclaurine Chemical Structure

Demethyl-Coclaurine Chemical Structure

CAS: 5843-65-2

Purity & Quality Control

Batch: Purity: 99.00%
99

Demethyl-Coclaurine Related Products

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Biological Activity

Description Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.
Targets
β2-AR [1] Akt [1] PI3K [1]

Chemical Information & Solubility

Molecular Weight 271.31 Formula

C16H17NO3

CAS No. 5843-65-2 SDF --
Smiles OC1=CC=C(CC2NCCC3=CC(=C(O)C=C23)O)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 54 mg/mL ( (199.03 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 7 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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