NSC348884

Catalog No.S8149

For research use only.

NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.

NSC348884 Chemical Structure

CAS No. 81624-55-7

Selleck's NSC348884 has been cited by 4 Publications

Purity & Quality Control

Choose Selective p53 Inhibitors

Other p53 Products

Biological Activity

Description NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
Targets
nucleophosmin [1]
(In Granta cells)
nucleophosmin [1]
(In LNCaP cells)
1.7 μM 4 μM
In vitro

NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis[1].

In vivo In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2].

Protocol (from reference)

Animal Research:

[2]

  • Animal Models: Mice bearing either orthotopic MDA-MB-231-GFP tumors (MDA231) or patient-derived HT17 and HT19 tumors
  • Dosages: 25 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(157.03 mM)
Water Insoluble
Ethanol '100 mg/mL

Chemical Information

Molecular Weight 636.79
Formula

C38H40N10

CAS No. 81624-55-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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