For research use only.
Catalog No.S0056 Synonyms: BCI, NSC 150117
CAS No. 15982-84-0
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
Purity & Quality Control
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|Description||(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.|
|In vitro||DMSO||63 mg/mL (198.47 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||BCI, NSC 150117|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT05003817||Not yet recruiting||Device: Percutaneous left ventricular unloading||Ischemic Heart Disease|Coronary Artery Disease||Guy''s and St Thomas'' NHS Foundation Trust|London School of Hygiene and Tropical Medicine|Queen Elizabeth Hospital Birmingham|Royal Bournemouth Hospital Bournemouth|St. George''s Hospital London|Belfast Health and Social Care Trust Belfast|King''s College Hospital London|King''s College London||August 2021||Phase 3|
|NCT04874974||Recruiting||Behavioral: Metacognitive and Defusion Training||Schizophrenia|Schizotypal Disorder|Delusional Disorder|Brief Psychotic Disorder|Shared Psychotic Disorder|Schizoaffective Disorder|Other Psychotic Disorder Not Due to A Substance or Known Physiological Condition|Unspecified Psychosis Not Due to a Substance or Known Physiological Condition|Manic Episode Severe With Psychotic Symptoms|Bipolar Disorder Current Episode Manic Severe With Psychotic Features|Bipolar Disorder Current Episode Depressed Severe With Psychotic Features|Major Depressive Disorder Single Episode Severe With Psychotic Features|Major Depressive Disorder Recurrent Severe With Psychotic Symptoms||Max-Planck-Institute of Psychiatry||May 10 2021||Not Applicable|
|NCT03827187||Not yet recruiting||Other: Motor imagery based EEG-BCI||Disorder of Consciousness|Paralysis|Motor Neuron Disease|Stroke|Physical Disability||University of Ulster|National Rehabilitation Hospital Ireland|St Conal''s Campus Rehabilitation Unit Letterkenny Ireland|Belfast Health and Social Care Trust|Western Health and Social Care Trust|South Eastern Health and Social Care Trust|Southern Health and Social Care Trust|Northern Health and Social Care Trust|Barnsley Hospital NHS Foundation Trust|NHS Lothian|Walton Centre NHS Foundation Trust|Hull University Teaching Hospitals NHS Trust|Northern Lincolnshire and Goole Hospitals NHS Foundation Trust|Imperial College Healthcare NHS Trust|Woodland Neuro rehab Center York (Christchurch Group)|Glenside care Salisbury|Frenchay Brain Injury Rehabilitation Centre Bristol|Royal Hospital for Neuro-disability||January 15 2021||Not Applicable|
|NCT04740463||Recruiting||--||Major Depressive Episode||University Hospital Montpellier||January 1 2021||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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