PI-103

For research use only.

Catalog No.S1038

76 publications

PI-103 Chemical Structure

CAS No. 371935-74-9

PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 134 In stock
USD 147 In stock
USD 270 In stock
USD 370 In stock
USD 590 In stock
USD 790 In stock
USD 1370 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's PI-103 has been cited by 76 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.
Features The first potent, synthetic mTOR inhibitor.
Targets
p110α [3]
(Cell-free assay)
p110β [3]
(Cell-free assay)
p110δ [3]
(Cell-free assay)
p110γ [3]
(Cell-free assay)
DNA-PK [3]
(Cell-free assay)
2 nM 3 nM 3 nM 15 nM 23 nM
In vitro

PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. [1] PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. [2] In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes. [2] PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
UCH-1  MV3BdI9xfG:|aYOgRZN{[Xl? NYjtdoFNOC5zLUGwJO69VQ>? NHzEd4wzPCCq MlLuSG1UVw>? NYP0SlJZcW6mdXPld{BieG:ydH;zbZM> NWH0OZVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1Nlg1PDFpPkG5OVI5PDRzPD;hQi=>
UCH-1  M{XVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInJZmcxNjBzLUGwJO69VQ>? MVO2JIQ> MmO3bY5pcWKrdIOgdJJwdGmoZYLheIlwdiCmb4PlJIRmeGWwZHXueIx6 NUnRU3hvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1Nlg1PDFpPkG5OVI5PDRzPD;hQi=>
UCH-1  NHewPVhHfW6ldHnvckBCe3OjeR?= M4TGcFAuPSEQvF2= M{LSNIlvcGmkaYTzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiYn;0bEBCU1RiYX7kJI1VV1JiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M1;rZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUK4OFQyLz5zOUWyPFQ1OTxxYU6=
HUVEC NGnneJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETRZZFKSzVyPUCuNFgh|ryP NWiwcZJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1PFQzOjdpPkG5OVg1OjJ5PD;hQi=>
SKOV-3 NVjCe|NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LiWWlEPTB;MD6xNkDPxE1? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV6NEKyO{c,OTl3OESyNlc9N2F-
PC3  M3zhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHTTWM2OD1yLkGwJO69VQ>? M4XRWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUi0NlI4Lz5zOUW4OFIzPzxxYU6=
DETROIT562 NUnVVlQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMUOg{txO M2TUVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUi0NlI4Lz5zOUW4OFIzPzxxYU6=
IGROV-1 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwME[g{txO MkDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OESyNlcoRjF7NUi0NlI4RC:jPh?=
U87MG MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTBOYM{UUN3ME2wMlE1KM7:TR?= NUf5Z3dlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1PFQzOjdpPkG5OVg1OjJ5PD;hQi=>
U118MG Mmr0SpVv[3Srb36gRZN{[Xl? M4jhb|AvOS1zIN88US=> NFnrTY0zPOLCiXlCpC=> NHPtcoNFVVOR M4rUOYlvcGmkaYTzJHBKO0tvbXXkbYF1\WRic3nncoFtcW6p M13UXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkOzOlg{Lz5zOU[zN|Y5OzxxYU6=
U138MG M4TZSGZ2dmO2aX;uJGF{e2G7 MWGwMlEuOSEQvF2= NFHVWmQzPOLCiXlCpC=> MWTEUXNQ MX;pcohq[mm2czDQTVNMNW2nZHnheIVlKHOrZ37hcIlv\w>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ|M{[4N{c,OTl4M{O2PFM9N2F-
U87MG Mn3OSpVv[3Srb36gRZN{[Xl? NXO5XGRrOC5zLUGg{txO MmDINlTjiImqwrC= MXvEUXNQ M4XmTIlvcGmkaYTzJHBKO0tvbXXkbYF1\WRic3nncoFtcW6p M4XJd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkOzOlg{Lz5zOU[zN|Y5OzxxYU6=
PC3  NI[xVoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOyOIg> MmntS2k2OMLiPTCxNFAhdk1? MnjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3NUGwOlEoRjJyNUWxNFYyRC:jPh?=
518A2 MYjGeY5kfGmxbjDBd5NigQ>? NUnQOWhVOC5yMEJihLMy6oDLzszN MnfjNlQhcA>? MX;zeZBxemW|c3XzJJBpd3OyaH;yfYxifGmxbjDv[kBxcG:|cHjheIllgWxiaX7vd4l1d2xiMz3rbY5ie2ViZH;3cpN1emWjbTD0ZZJo\XS| MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB2OEe4OUc,OjFyNEi3PFU9N2F-
Mel-Juso  MlfuSpVv[3Srb36gRZN{[Xl? NH36foUxNjByMfMAl|HjiIoQvF2= M2fQb|I1KGh? M4TNS5N2eHC{ZYPz[ZMheGixc4Doc5J6dGG2aX;uJI9nKHCqb4PwbIF1cWS7bDDpco9{cXSxbDCzMYtqdmG|ZTDkc5dve3S{ZXHtJJRiemendIO= MnPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyNEi3PFUoRjJzMES4O|g2RC:jPh?=
518A2  M4DLUWNmdGxiVnnhZoltcXS7IFHzd4F6 M{GzOVAvODIkgKOxNQKBkc7:TR?= NHLrfpI4OiCq M3\xNolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? M4DWcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMES4O|g2Lz5{MUC0PFc5PTxxYU6=
Mel-Juso M3;hUmNmdGxiVnnhZoltcXS7IFHzd4F6 NIr1OXAxNjBz4pETNVDjiIoQvF2= NFH2SXY4OiCq MVzpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB2OEe4OUc,OjFyNEi3PFU9N2F-
SF767 MXTGeY5kfGmxbjDBd5NigQ>? M4TrPFEh|ryP MVu0PEBp Mnz2bY5lfWOnczDheZRweGijZ3;zc41mKG[xcn3heIlwdg>? NILqbGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2Nlk6Oyd-MkGwOlI6QTN:L3G+
U373 NX\X[mJPTnWwY4Tpc44hSXO|YYm= MljlNUDPxE1? MUG0PEBp NGLvfpRqdmS3Y3XzJIF2fG:yaHHnc5NwdWViZn;ycYF1cW:w NY\SOZFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwOlI6QTNpPkKxNFYzQTl|PD;hQi=>
U87 NYHBdGtjTnWwY4Tpc44hSXO|YYm= M2DmelEh|ryP MUK0PEBp NV3HOnN2cW6mdXPld{BifXSxcHjh[49{d22nIH\vdo1ifGmxbh?= NITJO2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2Nlk6Oyd-MkGwOlI6QTN:L3G+
LN229 NFLXbppHfW6ldHnvckBCe3OjeR?= NYjoWpY3OSEQvF2= NIfpdpg1QCCq MWLpcoR2[2W|IHH1eI9xcGGpb4PvcYUh\m:{bXH0bY9v MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB4Mkm5N{c,OjFyNkK5PVM9N2F-
PC-9  M2izOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnUfGNlOC1|IN88US=> MU[3NkBp NILWVXBKSzVyPUCuPEDPxE1? M{nvb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkKwOFc1Lz5{MUKyNFQ4PDxxYU6=
HCC827 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2wMVMh|ryP MmnCO|IhcA>? MUXJR|UxRTBwMzFOwG0> MkDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{MkC0O|QoRjJzMkKwOFc1RC:jPh?=
HCC1937 MVTGeY5kfGmxbjDBd5NigQ>? MmnPNUDPxE1? MYOyOEBp NFfEUpRz\WS3Y3XzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiQVvU M37OVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEi4OVkxLz5{MkS4PFU6ODxxYU6=
SUM1315MO2 M3jCcWZ2dmO2aX;uJGF{e2G7 MnvoNUDPxE1? M3;ET|I1KGh? MVvy[YR2[2W|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW NIPFdZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFU6OCd-MkK0PFg2QTB:L3G+
SUM149PT M1L5XWZ2dmO2aX;uJGF{e2G7 NGrZfFAyKM7:TR?= MWeyOEBp Mnu1doVlfWOnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= MlT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEi1PVAoRjJ{NEi4OVkxRC:jPh?=
MDA-MB-436 MmXnSpVv[3Srb36gRZN{[Xl? M3ezWlEh|ryP M1joNVI1KGh? NVfGSlI3emWmdXPld{B1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIFHLWC=> M4mxcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEi4OVkxLz5{MkS4PFU6ODxxYU6=
KMS12-BM  Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TRb|AuOiEQvF2= MmK2NlQhcA>? MoPHTWM2OO,:nkKg{txO MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh{OUKzOEc,OjJ6MkmyN|Q9N2F-
NCI-H929 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnV[IQxNTJizszN NXPlfphlOjRiaB?= NFLV[G1KSzVyPUCuNlUh|ryP MnO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MkmyN|QoRjJ{OEK5NlM1RC:jPh?=
MM1S MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\EZ3QxNTJizszN NH:3T5AzPCCq M3P5N2lEPTB;MD61JO69VQ>? Mo[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MkmyN|QoRjJ{OEK5NlM1RC:jPh?=
MOLT-16 M1[5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWex5qCK|ryP NFn6eZM4KGR? MnWx[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 NFT0Npg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CzPFI4Oyd-MkOwN|gzPzN:L3G+
LOUCY MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GwRlHjiIoQvF2= NFTiWmg4KGR? MkPG[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 MnXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyM{iyO|MoRjJ|MEO4Nlc{RC:jPh?=
CCRF-CEM MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\PNgKBkc7:TR?= NXP0V2J{PyCm M4\idYRm[3KnYYPld{B1cGViY3XscEBvfW2kZYKgd4lodmmoaXPhcpRtgQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB|OEK3N{c,OjNyM{iyO|M9N2F-
PF-382 NELO[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XEUlHjiIoQvF2= NYfQZoxTPyCm NX7HO5No\GWlcnXhd4V{KHSqZTDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB|OEK3N{c,OjNyM{iyO|M9N2F-
MOLT-4 NUX4dndpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWx5qCK|ryP NYHkOpQ3PyCm M3O2cIRm[3KnYYPld{B1cGViY3XscEBvfW2kZYKgd4lodmmoaXPhcpRtgQ>? Ml;1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyM{iyO|MoRjJ|MEO4Nlc{RC:jPh?=
Jurkat NXzEXFlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKx5qCK|ryP NIPBU3Q4KGR? MlvG[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 Mk[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyM{iyO|MoRjJ|MEO4Nlc{RC:jPh?=
RPMI-8402 NYjsdZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG2TJpGOeLCid88US=> M3nTTlch\A>? Ml\o[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 NFXNOW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CzPFI4Oyd-MkOwN|gzPzN:L3G+
Karpas-45 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImzb44y6oDLzszN M4CyVVch\A>? MnrZ[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB|OEK3N{c,OjNyM{iyO|M9N2F-
KE37 NFvoVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCx5qCK|ryP Mo\KO{Bl MWHk[YNz\WG|ZYOgeIhmKGOnbHygcpVu[mW{IIPp[45q\mmlYX70cJk> NUfuTm06RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwN|gzPzNpPkKzNFM5Ojd|PD;hQi=>
ALL-SIL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV76dFVDOeLCid88US=> MXi3JIQ> MmPT[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 NXXqToFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwN|gzPzNpPkKzNFM5Ojd|PD;hQi=>
PEER NWXjWJdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYCx5qCK|ryP Mmn4O{Bl NHSyeVBl\WO{ZXHz[ZMhfGinIHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NHvkVFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CzPFI4Oyd-MkOwN|gzPzN:L3G+
SUP-T1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf6NgKBkc7:TR?= NUSxXYF5PyCm Mlfh[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDzbYdvcW[rY3HueIx6 MnvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyM{iyO|MoRjJ|MEO4Nlc{RC:jPh?=
DND41 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW5WFgy6oDLzszN MWC3JIQ> NIPXNnBl\WO{ZXHz[ZMhfGinIHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NHT5b5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CzPFI4Oyd-MkOwN|gzPzN:L3G+
HPB-ALL M1m0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32zflHjiIoQvF2= Mn;jO{Bl NXSzWpVS\GWlcnXhd4V{KHSqZTDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB|OEK3N{c,OjNyM{iyO|M9N2F-
TALL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLENHAy6oDLzszN MWq3JIQ> NXvkUGlS\GWlcnXhd4V{KHSqZTDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MmXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyM{iyO|MoRjJ|MEO4Nlc{RC:jPh?=
H3122 NFrE[IxHfW6ldHnvckBCe3OjeR?= NGfsU5AxNTNwMzFOwG0> M33HRVczKGh? NFi2dlBqdmS3Y3XzJINwdXCuZYTlJIRwf26{ZXf1cIF1cW:wIH;mJJBCU1R? M3L6blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkW5OVkyLz5{M{K1PVU6OTxxYU6=
HCC827 MWHGeY5kfGmxbjDBd5NigQ>? NFPnepMxNTNwMzFOwG0> Mn23O|IhcA>? MlrCbY5lfWOnczDjc41xdGW2ZTDkc5dvemWpdXzheIlwdiCxZjDwRWtV MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3OUW5NUc,OjN{NUm1PVE9N2F-
A549 NIPlWmpHfW6ldHnvckBCe3OjeR?= MUSwMVMvOyEQvF2= MknIO|IhcA>? Mn3HbY5lfWOnczDjc41xdGW2ZTDkc5dvemWpdXzheIlwdiCxZjDwRWtV Mn;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUm1PVEoRjJ|MkW5OVkyRC:jPh?=
HT1080 MXTBdI9xfG:|aYOgRZN{[Xl? M4PlNVMhyrWP MV[xNkBp Mk\MSG1UVw>? MkCyd4Vve2m2aYrld{BTTCClZXzsd{B1dyCGT2itbY5lfWOnZDDhdI9xfG:|aYO= NVHob|M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFA5ODlpPkKzN|AxQDB7PD;hQi=>
TP5014 MoLWRZBweHSxc3nzJGF{e2G7 Mn\VN{DDvU1? MV:xNkBp M17WTGROW09? MkjKd4Vve2m2aYrld{BTTCClZXzsd{B1dyCGT2itbY5lfWOnZDDhdI9xfG:|aYO= NFPN[WI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNFgxQSd-MkOzNFA5ODl:L3G+
RD M33sZ2Fxd3C2b4Ppd{BCe3OjeR?= M1u3UVMhyrWP NGnHeHcyOiCq MYjEUXNQ MX7z[Y5{cXSrenXzJHJFKGOnbHzzJJRwKESRWD3pcoR2[2WmIHHwc5B1d3Orcx?= M4fjW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CwPFA6Lz5{M{OwNFgxQTxxYU6=
SKNBE(2c) NETnOGRHfW6ldHnvckBCe3OjeR?= NHWyOGkyNjVxMj61M|Uh|ryP NUDISY95OjRiaB?= Mkf5bY5lfWOnczDHNeKh[2WubD3jfYNt\SCjcoLld5Qh[W6mIHHwc5B1d3Orcx?= M2HhN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{e4N|QyLz5{M{O3PFM1OTxxYU6=
SY5Y MYPGeY5kfGmxbjDBd5NigQ>? MlL6NU42NzJwNT:1JO69VQ>? Mn;FNlQhcA>? M1nMSolv\HWlZYOgS|HDqGOnbHytZ5lkdGViYYLy[ZN1KGGwZDDhdI9xfG:|aYO= MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|N{izOFEoRjJ|M{e4N|QyRC:jPh?=
MDA-MB-231 MkHQR4VtdCCYaXHibYxqfHliQYPzZZk> MY[wMlMh|ryP MknpO|IhcA>? NHKzTnhmdmijbnPld{BkgXSxdH;4bYMh\W[oZXP0d{Bw\iCSSUPLM2FMXCCyYYToe4F6KGmwaHnibZRwenN? NIDMXHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNVA4PCd-MkO2NFExPzR:L3G+
MDA-MB-468 MonVR4VtdCCYaXHibYxqfHliQYPzZZk> M{HD[lAvOyEQvF2= NHHZVZQ4OiCq M1vDcoVvcGGwY3XzJIN6fG:2b4jpZ{Bm\m[nY4TzJI9nKFCLM1uvRWtVKHCjdHj3ZZkhcW6qaXLpeI9zew>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMUC3OEc,OjN4MEGwO|Q9N2F-
SUM149PT MVTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MWOwMlMh|ryP MXu3NkBp MoK4[Y5p[W6lZYOgZ5l1d3SxeHnjJIVn\mWldIOgc4YhWEl|Sz;BT3QheGG2aIfhfUBqdmirYnn0c5J{ MlXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEGwO|QoRjJ|NkCxNFc1RC:jPh?=
RMS13 NWmw[3pySXCxcITvd4l{KEG|c3H5 MnrmNU8yNjVxMjFOwG0> NGn3T2s4OiCq NEHXNGJFVVOR M3r4Volv\HWlZYOgZ4F{eGG|ZT3k[ZBmdmSnboSgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiVV:xNlY> NFnvXXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OFkzPSd-MkO2PFQ6OjV:L3G+
RH30  NGTIVWRCeG:ydH;zbZMhSXO|YYm= Mn61NU8yNjVxMjFOwG0> MmfPO|IhcA>? NHTvbGdFVVOR M4fFTIlv\HWlZYOgZ4F{eGG|ZT3k[ZBmdmSnboSgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiVV:xNlY> M17U[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nki0PVI2Lz5{M{[4OFkzPTxxYU6=
TE671 MV7BdI9xfG:|aYOgRZN{[Xl? M2HDeFEwOS53L{Kg{txO M{\EcVczKGh? NXy0e41oTE2VTx?= NUPOWoRTcW6mdXPld{Bk[XOyYYPlMYRmeGWwZHXueEBieG:ydH;zbZMh[2:vYnnu[YQhf2m2aDDVU|EzPg>? NE\UZW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OFkzPSd-MkO2PFQ6OjV:L3G+
RD M2q1dWFxd3C2b4Ppd{BCe3OjeR?= NIPuOJYyNzFwNT:yJO69VQ>? NXuzOXBqPzJiaB?= NGHFbJhFVVOR MW\pcoR2[2W|IHPhd5Bie2VvZHXw[Y5l\W62IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKFWRMUK2 NUH0Xnp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFQ6OjVpPkKzOlg1QTJ3PD;hQi=>
FaDu MmnkSpVv[3Srb36gRZN{[Xl? NFTXS3UxNjJ3L{CuOU8yKM7:TR?= NVi0dWY3OjRiaB?= NWGwWG1ScW6qaXLpeJMhSWu2IIDoc5NxcG:{eXzheIlwdiC|aXfubYZq[2GwdHz5 NY\WZ|FkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVE1OjVpPkK0N|UyPDJ3PD;hQi=>
UT5 M2iyRWZ2dmO2aX;uJGF{e2G7 MnLlNE4zPS9yLkWvNUDPxE1? NED1ZZAzPCCq M2TVNolvcGmkaYTzJGFsfCCyaH;zdIhwenmuYYTpc44he2mpbnnmbYNidnSueR?= NFnNd4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1NVQzPSd-MkSzOVE1OjV:L3G+
SAS MYLGeY5kfGmxbjDBd5NigQ>? NFjvRpkxNjJ3L{CuOU8yKM7:TR?= M4r3[FI1KGh? MoHjbY5pcWKrdIOgRYt1KHCqb4PwbI9zgWyjdHnvckB{cWewaX\pZ4FvfGy7 M1exdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{WxOFI2Lz5{NEO1NVQzPTxxYU6=
H661 MWDGeY5kfGmxbjDBd5NigQ>? MnnDNE4zPS9yLkWvNUDPxE1? NEfTbHczPCCq MorGbY5pcWKrdIOgRYt1KHCqb4PwbI9zgWyjdHnvckB{cWewaX\pZ4FvfGy7 MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3MUSyOUc,OjR|NUG0NlU9N2F-
H460 Mmn0SpVv[3Srb36gRZN{[Xl? MlfBNE4zPS9yLkWvNUDPxE1? MVqyOEBp MYLpcohq[mm2czDBb5QheGixc4Doc5J6dGG2aX;uJJNtcWeqdHz5 MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3MUSyOUc,OjR|NUG0NlU9N2F-
A549 NFvRVJFHfW6ldHnvckBCe3OjeR?= M4HvU|AvOjVxMD61M|Eh|ryP NEHsZnAzPCCq Mkn4bY5pcWKrdIOgRYt1KHCqb4PwbI9zgWyjdHnvckB{dGmpaITsfS=> NWfEWWw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVE1OjVpPkK0N|UyPDJ3PD;hQi=>
NUGC4 LG M3nkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\oeFBKSzVyPUG0MlAhyrFiNT6zNlEh|ryP M3vFPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUm3OFc5Lz5{NEW5O|Q4QDxxYU6=
NUGC4 HG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j4cmlEPTB;MUSuNEDDuSB|LkmxN{DPxE1? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV7N{S3PEc,OjR3OUe0O|g9N2F-
MKN45 LG NG\hOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S1WWlEPTB;MD64O{DDuSByLkCzNEDPxE1? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV7N{S3PEc,OjR3OUe0O|g9N2F-
MKN45 HG NIPr[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFwMEGgxtEhOC5yNUGg{txO MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV7N{S3PEc,OjR3OUe0O|g9N2F-
HGC27 LG NFfn[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEKgxtEhOC5yMESg{txO NEfHZoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW5O|Q4QCd-MkS1PVc1Pzh:L3G+
HGC27 HG NXvXT2t4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSx[WlKSzVyPUCuN|ghyrFiMD6wNlIh|ryP M4m5N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUm3OFc5Lz5{NEW5O|Q4QDxxYU6=
AGS LG MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqxTWM2OD1yLkC1JOKyKDBwMECxJO69VQ>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV7N{S3PEc,OjR3OUe0O|g9N2F-
AGS HG NFLCPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPXeXRKSzVyPUCuOlghyrFiMD6wN|Eh|ryP M1HBeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUm3OFc5Lz5{NEW5O|Q4QDxxYU6=
SW982 NWmxbm01SXCxcITvd4l{KEG|c3H5 Ml3HNE4xOS1yLkWg{txO NYLLSFZXPDhiaB?= M1HuN4lv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NVHwdYhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PVU3OzJpPkK0Olk2PjN{PD;hQi=>
SW872 MoLORZBweHSxc3nzJGF{e2G7 MmX2NE4xOS1yLkWg{txO NV\iNml{PDhiaB?= NUiw[WtscW6mdXPld{BieG:ydH;zbZMh\G:|ZTDk[ZBmdmSnboTsfS=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ7NU[zNkc,OjR4OUW2N|I9N2F-
SW982 NVTMW4JTTnWwY4Tpc44hSXO|YYm= Mn;mNE4xOS1yLkWg{txO MYSyOEBp NWL2XoRZemWmdXPld{BCU1RicHjvd5Bpd3K7bHH0bY9vKCiyQVvULUBidmRiNFXCVFEheGixc4Doc5J6dGG2aX;uJEhxPEWEUEGpJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyxsA> NH[xfpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[5OVY{Oid-MkS2PVU3OzJ:L3G+
SW872 MnXESpVv[3Srb36gRZN{[Xl? MUiwMlAyNTBwNTFOwG0> Mn;3NlQhcA>? NW[0[INUemWmdXPld{BCU1RicHjvd5Bpd3K7bHH0bY9vKCiyQVvULUBidmRiNFXCVFEheGixc4Doc5J6dGG2aX;uJEhxPEWEUEGpJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyxsA> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ7NU[zNkc,OjR4OUW2N|I9N2F-
HS578T NVLaSVJ7TnWwY4Tpc44hSXO|YYm= NEDXcG4xNjBzLUGwJO69VQ>? M4TpelI1KGh? M4jsUoRwf26{ZXf1cIF1\XNidHjlJIxmfmWuczDv[kDPui2WclPQNUwh[y2PeXOgZY5lKGO7Y3zpckBGKHC{b4TlbY5{yqB? NYHx[XQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlE1OTlpPkK1O|IyPDF7PD;hQi=>
MDA-MB-231 NWLFRZJRTnWwY4Tpc44hSXO|YYm= NEK1U4sxNjBzLUGwJO69VQ>? M2KyOFI1KGh? MVjkc5dvemWpdXzheIV{KHSqZTDs[ZZmdHNib3[g{tIuXHKFUEGsJIMuVXmlIHHu[EBkgWOuaX6gSUBxem:2ZXnud:Kh NE\xbYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyNVQyQSd-MkW3NlE1OTl:L3G+
MDA-MB-468 MknPSpVv[3Srb36gRZN{[Xl? MYOwMlAyNTFyIN88US=> MXeyOEBp MVrkc5dvemWpdXzheIV{KHSqZTDs[ZZmdHNib3[g{tIuXHKFUEGsJIMuVXmlIHHu[EBkgWOuaX6gSUBxem:2ZXnud:Kh NWnhe4V3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlE1OTlpPkK1O|IyPDF7PD;hQi=>
SUM149PT M3nISWNmdGxiVnnhZoltcXS7IFHzd4F6 NUW3Rm13OC1|IN88US=> NH[2UYc4OiCq M1vod4lvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? M2TlPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{KxOFE6Lz5{NUeyNVQyQTxxYU6=
MDA-MB-436 NWnQSVV4S2WubDDWbYFjcWyrdImgRZN{[Xl? MlTwNE0{KM7:TR?= MX63NkBp NUG0cXFrcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MkG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkG0NVkoRjJ3N{KxOFE6RC:jPh?=
MDA-MB-468 MnjrR4VtdCCYaXHibYxqfHliQYPzZZk> MXSwMVMh|ryP NF\qN244OiCq NEPZfZZqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MUSxPUc,OjV5MkG0NVk9N2F-
MDA-MB-231 MlH0R4VtdCCYaXHibYxqfHliQYPzZZk> NWfndHhHOC1|IN88US=> NEjjOHc4OiCq MoPxbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? M4jVWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{KxOFE6Lz5{NUeyNVQyQTxxYU6=
BT549 NUPnPZFkS2WubDDWbYFjcWyrdImgRZN{[Xl? MoHtNE0{KM7:TR?= NYDF[ZpCPzJiaB?= NWXvbpY6cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MUSxPUc,OjV5MkG0NVk9N2F-
HS578T M4PaU2NmdGxiVnnhZoltcXS7IFHzd4F6 MoXBNE0{KM7:TR?= MX63NkBp M3rCdolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NHnlT|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyNVQyQSd-MkW3NlE1OTl:L3G+
VJ NGPtW|hCeG:ydH;zbZMhSXO|YYm= MVqxM|EvPS9{IN88US=> M2fLTFczKGh? MYTpcoR2[2W|IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKEeDTmS2NS=> NV3pOo9lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OFk{PzhpPkK1O|Q6Ozd6PD;hQi=>
RH30  NIO1[4FCeG:ydH;zbZMhSXO|YYm= MVixM|EvPS9{IN88US=> Mn[0O|IhcA>? MVzpcoR2[2W|IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKEeDTmS2NS=> M{TWV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{S5N|c5Lz5{NUe0PVM4QDxxYU6=
RMS13 MUXBdI9xfG:|aYOgRZN{[Xl? NIH4VowyNzFwNT:yJO69VQ>? MmntO|IhcA>? MmTGbY5lfWOnczDhdI9xfG:|aYOgZ49u[mmwZXSge4l1cCCJQV7UOlE> NYPER3pRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OFk{PzhpPkK1O|Q6Ozd6PD;hQi=>
TE381.T MUXBdI9xfG:|aYOgRZN{[Xl? M1zRSlEwOS53L{Kg{txO NF;WVVA4OiCq M17xdIlv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiR1HOWFYy MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUO3PEc,OjV5NEmzO|g9N2F-
RD MYHBdI9xfG:|aYOgRZN{[Xl? Ml;xNU8yNjVxMjFOwG0> M4TKSlczKGh? M2DJVolv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiR1HOWFYy NG\UWWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0PVM4QCd-MkW3OFk{Pzh:L3G+
G 40 DC MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqwMlA2NTJyIN88US=> NVjDepR[OjRxN{KgbC=> MXfEUXNQ NUHZ[ndvcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF{MUK1NUc,OjZzMkGyOVE9N2F-
G 38 DC NWLVSGRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zGbVAvODVvMkCg{txO NHPvW3AzPC95MjDo MUPEUXNQ M3P2SIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51dHl? NVyybodCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNlEzPTFpPkK2NVIyOjVzPD;hQi=>
G 35 DC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvYfJIxOC5yNT2yNEDPxE1? MWiyOE84OiCq NIO5V5ZFVVOR M4LwdolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51dHl? NIDKb5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGyNVI2OSd-Mk[xNlEzPTF:L3G+
G 40 SC M1O4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv0NE4xPS1{MDFOwG0> MUKyOE84OiCq MnnDSG1UVw>? MXXpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueIx6 NX\ocVZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNlEzPTFpPkK2NVIyOjVzPD;hQi=>
G 38 SC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDGVHgxNjB3LUKwJO69VQ>? M3XL[FI1Nzd{IHi= M3rnTmROW09? NV3GWG1KcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NGnHc|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGyNVI2OSd-Mk[xNlEzPTF:L3G+
G 35 SC Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWwMlA2NTJyIN88US=> M3;UOlI1Nzd{IHi= NHTYcZJFVVOR Mn\lbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBidmRidHnt[UBl\XCnbnTlcpRtgQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF{MUK1NUc,OjZzMkGyOVE9N2F-
SH-SY5Y  NWjyWHBQSXCxcITvd4l{KEG|c3H5 MVexJO69VQ>? MoH0NE42NTJ2IHi= NF\pemF{\W6|aYTpfoV{KG6ndYLvZoxie3SxbXGgZ4VtdHNidH:g[I95d3K3YnnjbY4ucW6mdXPl[EBieG:ydH;zbZM> NV33eoNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlQ3QDFpPkK2NlI1PjhzPD;hQi=>
SH-SY5Y M1rjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17ISFAuQCEQvF2= MXKyOE81QC95MjDo NYLnb2RqcW6mdXPld{B1cW2nLTDhcoQh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgbY5pcWKrdHnvckBwdiCQQjDj[YxtKGe{b4f0bC=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{NE[4NUc,OjZ{MkS2PFE9N2F-
SK-N-BE MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[wMVgh|ryP MkjRNlQwPDhxN{KgbC=> MUjpcoR2[2W|IITpcYUuKGGwZDDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCrbnjpZol1cW:wIH;uJG5DKGOnbHyg[5Jwf3Sq MlS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkS2PFEoRjJ4MkK0OlgyRC:jPh?=
TT MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVK5NWNIOTNiZHH5dy=> MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFSWIHPlcIx{KGGodHXyJFE{KGSjeYOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVAvODB{Mt88UU4> MmTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6NEm5O|EoRjF6OES5PVcyRC:jPh?=
Sf9 NUP2VW9qTnWwY4Tpc44h[XO|YYm= MmXGN|AhdWmwcx?= MlfITY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd{03NXSjZ3fl[EBnfWyuIHzlcod1cCCqdX3hckBRUTONYXzwbIEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJJNnQSClZXzsd{Bi\nSncjCzNEBucW6|IHL5JHRTNU[URWSgZZN{[XluIFnDOVA:OC5yMUe5{txONg>? NIXTTGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFc5Pid-MkS5NFA4QDZ:L3G+
HEK293T MXzGeY5kfGmxbjDhd5NigQ>? M2HnNlE2KG2rboO= M{PPXWlvcGmkaYTpc44hd2ZibWTPVmMyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[W[2ZYKgNVUhdWmwczDpckBxemW|ZX7j[UBw\iCpYX3tZU1cOzKfUD3BWHAh[nliaHnnbE11cHKxdXfodJV1KHOlcnXlcolv\yCjc4PhfUwhUUN3ME2wMlAz|ryPLh?= NInWfXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKxNVQ5OCd-MkmyNVE1QDB:L3G+
Sf9 NHO4[o5HfW6ldHnvckBie3OjeR?= MoPBN|AhdWmwcx?= NIi2VXFKdmirYnn0bY9vKG:oIFfTWE11[WepZXSg[pVtdCCuZX7neIghcHWvYX6gVGk{U2GucHjhJGQ5OTCDIH31eIFvfCCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMucW6oZXP0[YQhe2Z7IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhXFJvRmLFWEBie3OjeTygTWM2OD1yLkC3OO69VS5? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEe4Okc,OjR7MEC3PFY9N2F-
Sf9 NHPxcmVHfW6ldHnvckBie3OjeR?= NVjZXJkxOzBibXnudy=> NEnHXG1KdmirYnn0bY9vKG:oIFfTWE11[WepZXSg[pVtdCCuZX7neIghcHWvYX6gVGk{U2GucHjhJHk5Oz[DIH31eIFvfCCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMucW6oZXP0[YQhe2Z7IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhXFJvRmLFWEBie3OjeTygTWM2OD1yLke5OlPPxE1w M2LJSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwO|g3Lz5{NEmwNFc5PjxxYU6=
Caco2 NVvyPW96SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYn5XHNEPDhiaILz MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOjY3:yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nMYJie2WmIHHzd4F6NCCLQ{WwQVAvQM7:TT6= M2foUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkW1NlE3Lz5|ME[1OVIyPjxxYU6=
Caco2 NWrUO3NvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX;tOZJHPDhiaILz MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOjY3:yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KEixZXPod5QhOzN2MjDkfYUhe3SjaX7pcoch[mG|ZXSgZZN{[XluIFnDOVA:OC57zszNMi=> Mn7NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkO1OlYoRjJ|ME[zOVY3RC:jPh?=
HCT116 NIDhXndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUG0PEBpenN? NELhOGZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{BqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDIc4VkcHO2IEOzOFIh\HmnIIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBKSzVyPUJOwG0v M1;TVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[zOVY3Lz5{M{C2N|U3PjxxYU6=
Sf9 M1nGdmZ2dmO2aX;uJIF{e2G7 MmfuN|AhdWmwcx?= M4DEOWlvcGmkaYTpc44hd2ZiR2PUMZRi\2enZDDmeYxtKGynbnf0bEBpfW2jbjDQTVNM[WyyaHGgUVc4OkFibYX0ZY51KGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{1qdm[nY4Tl[EB{\jliY3XscJMh[W[2ZYKgN|AhdWmwczDifUBVWi2IUlXUJIF{e2G7LDDJR|UxRTFwMEO0OO69VS5? M2DFXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwO|g3Lz5{NEmwNFc5PjxxYU6=
PC3 NGjNeXdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MorPOFghcHK| M1KzZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nMYJie2WmIHHzd4F6NCCLQ{WwQVEvOs7:TT6= NV3KfY51RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C2OVUzOTZpPkOwOlU2OjF4PD;hQi=>
HuH7 M1PJWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVu0PEBpenN? NXv0dFBkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IFjv[YNpe3RiM{O0NkBlgWVic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGlEPTB;MT61{txONg>? NV;afmJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlM2PjZpPkKzNFY{PTZ4PD;hQi=>
PC3 NHXMU2xCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmfqOFghcHK| NYTFTlBVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgbY5kfWKjdHXkJIZweiB2ODDodpMh[nliSH;lZ4h{fCB|M{SyJIR6\SC|dHHpcolv\yCkYYPl[EBie3OjeTygTWM2OD1zLkZOwG0v NWrBVnlGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlM2PjZpPkKzNFY{PTZ4PD;hQi=>
Caco2 MlvtR5l1d3SxeHnjbZR6KGG|c3H5 MojlOFghcHK| MmDOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR4FkdzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JGhw\WOqc4SgN|M{PDJic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGlEPTB;Mt88UU4> M4OwdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG0NlMyLz5{OEKxOFI{OTxxYU6=
HaCaT MoTvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MX:0PEBpenN? NIjJfGVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjhR4FVKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDIc4VkcHO2IEOzN|QzKHO2YXnubY5oNWKjc3XkJIF{e2G7LDDJR|UxRTMQvF2u NYLrc4dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C2OVUzOTZpPkOwOlU2OjF4PD;hQi=>
NCI-H727 NVvOPXlMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXS0PEBpenN? MkfqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFczPyClZXzsd{BqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDIc4VkcHO2IEOzOFIh\HmnIIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBKSzVyPUROwG0v NGXETYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2N|U3Pid-MkOwOlM2PjZ:L3G+
MCF7 M1e2fmN6fG:2b4jpZ4l1gSCjc4PhfS=> MmPkOFghcHK| NWXxcHdvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVPPxE1w MkGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyMUG0NlQoRjJ6MEGxOFI1RC:jPh?=
HCT116 NE\5PGtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mn3UOFghcHK| MkDNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFjv[YNpe3RiM{OzOFIhe3SjaX7pcocu[mG|ZXSgZZN{[XluIFnDOVA:O87:TT6= MonYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB4NUWyNVYoRjNyNkW1NlE3RC:jPh?=
HaCaT NVHSXoplS3m2b4TvfIlkcXS7IHHzd4F6 MWK0PEBpenN? NXux[IRVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGGFYWSgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KEixZXPod5QhOzN|NEKgd5RicW6rbnegZoF{\WRiYYPzZZktKEmFNUC9N{42|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJzNEKzNUc,Ojh{MUSyN|E9N2F-
HCT116 M1S2RWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIjBXHA1QCCqcoO= NFfveWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KEixZXPod5QhOzN|NEKgd5RicW6rbnegZoF{\WRiYYPzZZktKEmFNUC9N{46|ryPLh?= NXi0V5pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNVQzOzFpPkK4NlE1OjNzPD;hQi=>
A549 NVHGflJGS3m2b4TvfIlkcXS7IHHzd4F6 NHrRbGQ1QCCqcoO= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NN88UU4> MmXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyMUG0NlQoRjJ6MEGxOFI1RC:jPh?=
MIAPaCa2 NYLSc3JZS3m2b4TvfIlkcXS7IHHzd4F6 Mlf1OFghcHK| NV3PUINbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUmDUHHDZVIh[2WubIOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14zszNMi=> NHXMXIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVQzPCd-MkiwNVE1OjR:L3G+
HuH7 NIm0bm1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYXTZ|JHPDhiaILz NVfhZmVUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDIc4VkcHO2IEOzN|QzKHO2YXnubY5oNWKjc3XkJIF{e2G7LDDJR|UxRTcQvF2u M2HEbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkW1NlE3Lz5|ME[1OVIyPjxxYU6=
ECV304 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4rs[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRVPWN|A1KGOnbHzzMEBKSzVyPU[uN:69VS5? MoL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzM{CxN|MoRjJ{MUOwNVM{RC:jPh?=
Bel7404 NWDLNZViSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFQh[2WubIOsJGlEPTB;N988UU4> NF7vOpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oyd-MkKxN|AyOzN:L3G+
PC3 NX7MU4JYS3m2b4TvfIlkcXS7IHHzd4F6 NWHrflQzPDhiaILz NIXSNYNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JGhw\WOqc4SgN|M{PDJic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGlEPTB;Nz62{txONg>? M1HNcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG0NlMyLz5{OEKxOFI{OTxxYU6=
HepG2 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NUGwOIZvPDhiaILz M1;BNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9PO69VS5? NHS4S|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVQzPCd-MkiwNVE1OjR:L3G+
MDA-MB-231 NXexVVZySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3LhUVQ5KGi{cx?= NFOwXXVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEixZXPod5QhOzN|NEKgd5RicW6rbnetZoF{\WRiYYPzZZktKEmFNUC9PO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ3NUKxOkc,OzB4NUWyNVY9N2F-
MDA-MB-231 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NEXHcmg1QCCqcoO= M4rLcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBJd2WlaIP0JFM{PDJiZInlJJN1[WmwaX7nJIJie2WmIHHzd4F6NCCLQ{WwQVE2|ryPLh?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4M{W2Okc,OjNyNkO1OlY9N2F-
MCF7 MmfmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2f4UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczygTWM2OD1{Mj60{txONg>? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|MEGzN{c,OjJzM{CxN|M9N2F-
HEK293 NUDnbFFNTnWwY4Tpc44h[XO|YYm= M3;LdVAvPXWP NHnadVRKdmirYnn0bY9vKG:oIGDLRk1UPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDJS2YuOSC2cnXheIVlKEiHS{K5N{Bk\WyuczDheEAxNjW3TR?= NYPLZ3R7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4OVAzOTRpPkG3PFUxOjF2PD;hQi=>
U87 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NIjo[ngxNjB2IITvJFExKHWP NGXlUY44OiCqcoO= NWjifWNMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFch[2WubIOgbIFz[m:{aX7nJI12fGG2aX;ud{BqdiCSSTizLWsheGG2aIfhfUBkd22yb37lcpR{KGG2IECuNFQhfG9iMUCgeW0h[W[2ZYKgO|IhcHK|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfS=> M4PiOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5PVcyLz5zOEi0PVk4OTxxYU6=
LN229 NFrzOlZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2O3bVAvODRidH:gNVAhfU1? Mly0O|IhcHK| M{fN[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTF6yNlkh[2WubIOgbIFz[m:{aX7nJI12fGG2aX;ud{BqdiCSSTizLWsheGG2aIfhfUBkd22yb37lcpR{KGG2IECuNFQhfG9iMUCgeW0h[W[2ZYKgO|IhcHK|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfS=> MlPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6NEm5O|EoRjF6OES5PVcyRC:jPh?=
U87 MYXD[YxtKGO7Y3zlJIF{e2G7 NIHFO5ozNjVidV2= MXyyOEBpenN? NFH5V|lE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBWQDdiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFIvPSC3TTDh[pRmeiB{NDDodpMh[nliRlHDV{BidmGueYPpdy=> NVHjcHZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFk6PzFpPkG4PFQ6QTdzPD;hQi=>
LN229 M1m4NWNmdGxiY4njcIUh[XO|YYm= Mnr1Nk42KHWP NY\CdnpuOjRiaILz NGjpO4lE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBNVjJ{OTDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS|EheGijc3WgZZQhOi53IIXNJIFnfGW{IEK0JIhzeyCkeTDGRWNUKGGwYXz5d4l{ NF;STIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEi0PVk4OSd-MUi4OFk6PzF:L3G+
SEG1 M3TRTWNmdGxiY4njcIUh[XO|YYm= NWDkeZRuOi53IIXN MoHoNlQhcHK| M1O3PWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJHNGTzFiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFIvPSC3TTDh[pRmeiB{NDDodpMh[nliRlHDV{BidmGueYPpdy=> M2DadVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5PVcyLz5zOEi0PVk4OTxxYU6=
TT MVPGeY5kfGmxbjDhd5NigQ>? MkXZNE4xPCC2bzCxNEB2VQ>? MkTENkBpenN? NIXhN29KdmirYnn0bY9vKG:oIGO2T{BifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKFSWIHPlcIx{KGG2IECuNFQhfG9iMUCgeW0h[W[2ZYKgNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M2\BOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5PVcyLz5zOEi0PVk4OTxxYU6=
K562 M3LnT2NmdGxiY4njcIUh[XO|YYm= NIXCTXIzNjVidV2= MYCyOEBpenN? MmXzR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gT|U3OiClZXzsd{Bp[XKkb4LpcochSmO{L1HicEBo\W6nIHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNE9IOSCyaHHz[UBifCB{LkWgeW0h[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXN? NGL2VnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEi0PVk4OSd-MUi4OFk6PzF:L3G+
K562 NX\WfJpOS2WubDDjfYNt\SCjc4PhfS=> M4fKOlIvPSC3TR?= NIXFR|czPCCqcoO= NEDUR|hE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBMPTZ{IHPlcIx{KGijcnLvdolv\yCEY4KvRYJtKFR|MUXJJI12fGGwdDDn[Y5mKGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG|ZTDheEAzNjVidV2gZYZ1\XJiMkSgbJJ{KGK7IF\BR3Mh[W6jbInzbZM> M2nXU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5PVcyLz5zOEi0PVk4OTxxYU6=
BA/F3 NVyxXnFXS2WubDDjfYNt\SCjc4PhfS=> NHPXUlAzNjVidV2= MUeyOEBpenN? MonzR4VtdCCleXPs[UBienKnc4SgbY4hdW:3c3WgRmEwTjNiY3XscJMhcGG{Yn;ybY5oKEKlcj;BZowh\2WwZTDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|AwTzFicHjhd4Uh[XRiMj61JJVOKGGodHXyJFI1KGi{czDifUBHSUOVIHHuZYx6e2m| MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh2OUm3NUc,OTh6NEm5O|E9N2F-
BA/F3 M3i5fmNmdGxiY4njcIUh[XO|YYm= NYT1[nk3Oi53IIXN MV2yOEBpenN? NFfTZpVE\WyuIHP5Z4xmKGG{cnXzeEBqdiCvb4Xz[UBDSS:IMzDj[YxteyCqYYLic5JqdmdiQnPyM2FjdCCWM{G1TUBufXSjboSg[4Vv\SCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS|EheGijc3WgZZQhOi53IIXNJIFnfGW{IEK0JIhzeyCkeTDGRWNUKGGwYXz5d4l{ M1\CW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5PVcyLz5zOEi0PVk4OTxxYU6=
Rh30 MXvD[YxtKGO7Y3zlJIF{e2G7 NVzrO|NMOSC2bzCxNEB2VQ>? MVLD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDSbFMxKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFexJINmdGxicH;weYxifGmxbjDheEAyKHSxIEGwJJVOKGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqew>? NH\sRlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oyd-MkKxN|AyOzN:L3G+
TC32 M2TnS5FJXFNiYYPzZZk> NHziR4hyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiVFOzNkBk\Wyucx?= NIHqO2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
DAOY M1HxTZFJXFNiYYPzZZk> MU\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? NY\nSnlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SJ-GBM2 MV3xTHRUKGG|c3H5 NWLWWJg3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM> NYrBSnRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673 MW\xTHRUKGG|c3H5 MYPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSTZ5MzDj[Yxtew>? M1:4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC NGiwc5NyUFSVIHHzd4F6 NXPkfmM5eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM> M1K2VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37 NGq4bVlyUFSVIHHzd4F6 NF;sXYlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStN|ch[2WubIO= M1rjW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1 MV;xTHRUKGG|c3H5 NXTyc2NMeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CMWVD[zFiY3XscJM> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Saos-2 NXz6OpNReUiWUzDhd5NigQ>? NEC0c3ZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU3Hvd{0zKGOnbHzz NVT0foNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-SH MkHtdWhVWyCjc4PhfS=> Mn:zdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tV2gh[2WubIO= NGDrWJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB1643 MXXxTHRUKGG|c3H5 MV7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| NFzhbpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 MWPxTHRUKGG|c3H5 NIDjOohyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTFHOMVUh[2WubIO= NXiyOm5HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh18 MlLpdWhVWyCjc4PhfS=> NW[4fHJyeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO= NFzFWFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
OHS-50 NIHr[WhyUFSVIHHzd4F6 MlfIdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE:KUz21NEBk\Wyucx?= M1[yfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD MY\xTHRUKGG|c3H5 NVGzbWVreUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGLEJINmdGy| NF3xOoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
MG 63 (6-TG R) MVXxTHRUKGG|c3H5 MVvxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? NYLaO5k5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh30 MYjxTHRUKGG|c3H5 MlPadWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqM{CgZ4VtdHN? NImyb3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Rh41 MVPxTHRUKGG|c3H5 NHTCTGpyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUni0NUBk\Wyucx?= NXL5S4JpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 Ml24dWhVWyCjc4PhfS=> MXPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDORlE3PDNiY3XscJM> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
A673 NVTuO2hZeUiWUzDhd5NigQ>? M{fSdJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGE3PzNiY3XscJMq MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-MC M{LDVZFJXFNiYYPzZZk> NGPDfZByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLV3DJINmdGy| NHHNSoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 M1:wdpFJXFNiYYPzZZk> MmS4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUGFPNTViY3XscJM> MlrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1 M2ewZZFJXFNiYYPzZZk> NH;6N3ZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSi2HQnOxJINmdGy| MkPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2 MYnxTHRUKGG|c3H5 MUTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTTk1ISk1{IHPlcIx{ MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
BT-37 NGXISJdyUFSVIHHzd4F6 M{H6TZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{ NVPqclVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
TC32 NHLqVnRyUFSVIHHzd4F6 NYjNblhmeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) NUXp[VJreUiWUzDhd5NigQ>? MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDNS{A3OyBqNj3US{BTMSClZXzsdy=> MlHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Rh41 NYjjNHFIeUiWUzDhd5NigQ>? NYDlXFh4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmh2MTDj[Yxtew>? M3\5WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18 MWPxTHRUKGG|c3H5 MUDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSbFE5KGOnbHzz MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Saos-2 MUPxTHRUKGG|c3H5 NIe1dIJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBU[W:|LUKgZ4VtdHN? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
OHS-50 MnfwdWhVWyCjc4PhfS=> M37iT5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>? MnLPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH M4fqVJFJXFNiYYPzZZk> MnSwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2VSDDj[Yxtew>? M13CXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Caco2 M{\hb2NmdGxiY4njcIUh[XO|YYm= NGPPSllE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBE[WOxMjDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GvV{BxcGG|ZTDifUBJd2WlaIP0JJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeR?= MoHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUSyN|EoRjJ6MkG0NlMyRC:jPh?=
HCT116 NFjWXo1E\WyuIHP5Z4xmKGG|c3H5 NY\uRYgyS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNk9OKHCqYYPlJIJ6KEixZXPod5Qhe3SjaX7pcoch[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5 NFXiUG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxOFI{OSd-MkiyNVQzOzF:L3G+
PC3 MYPD[YxtKGO7Y3zlJIF{e2G7 NVXE[oh3S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMT;TJJBp[XOnIHL5JGhw\WOqc4Sgd5RicW6rbnegZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7 MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJzNEKzNUc,Ojh{MUSyN|E9N2F-
HaCaT MWrD[YxtKGO7Y3zlJIF{e2G7 Mo\iR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gTIFE[VRiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzL2OgdIhie2ViYomgTI9m[2i|dDDzeIFqdmmwZzDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? NWLxU|R6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNVQzOzFpPkK4NlE1OjNzPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-S6K / S6K / p-S6 / S6 / p-p38 / p38; 

PubMed: 18922908     


Immunodetection of the levels of P-Akt, Akt, P-S6K, S6K, P-S6, S6, P-p38 or p38 of EC-vGPCR cells treated with increasing doses of PI-103 or DMSO (control) for 6 hours.

p-GSK3 / GSK3 / p-BAD / BAD / p-MDM2 / MDM2 / p-p27 / p27 ; 

PubMed: 18922908     


Immunodetection of the levels of P-Akt, Akt, P-GSK3, GSK3, P-BAD BAD, P-Mdm2, Mdm2, P-p27 or p27 of EC-vGPCR cells treated with increasing doses of PI-103 or DMSO (control) for 6 hours.

β-TrCP1 / p-mTOR; 

PubMed: 25721419     


PI-103 reduced the level of β-TrCP1 protein in TNBC cells. Cells were treated with 3 μm of PI-103 for 24 h and subjected to western blot analysis with indicated antibodies. HSP90 or β-actin was used as a loading control.

18922908 25721419
Immunofluorescence
autophagosomes / autolysosomes; 

PubMed: 26814436     


mRFP-GFP-LC3 stably expressing HeLa cells were treated with vehicle, PI (1uM), Baf (100nM) or PI (1uM)+Baf (100nM) for 20 hours. Cells were then fixed and confocal images were acquired. The numbers of autophagosomes (green vesicles) and autolysosomes (red vesicles minus green vesicles) were assessed with automated Cellomics microscopy (n = 12). Data are shown as mean ±sd. ***: P < 0.001. Scale bar: 20um.

26814436
Growth inhibition assay
Cell viability; 

PubMed: 25721419     


PI-103 reduced the viable TNBC cells in a dose-dependent manner. Cells were treated with increasing amounts of PI-103 up to 72 h and the viable cells were measured by MTT assay. Data from two independent experiments performed in triplicate are shown as mean±s.e.m.

25721419
In vivo When tumors reach 50-100 mm3, animals are randomized and treated with vehicle or PI-103. PI-103 exhibits significant activity, decreasing average tumor size by 4-fold after 18 days. [2] Mice treated with PI-103 have no obvious signs of toxicity premorbidly (based on body weight, food and water intake, activity, and general exam) or at necropsy. Treated tumors display decreased levels of phosphorylated Akt and S6, consistent with blockade of p110α and mTOR. PI-103 treatment is cytostatic to glioma xenografts. [2]

Protocol

Kinase Assay:[3]
- Collapse

Enzyme Assays:

Phosphatidylinositide 3-kinase inhibitory activity was determined using a scintillation proximity assay in the presence of 1 μmol/L ATP. Inhibition of mTOR protein kinase was determined using a TR-FRET-based LanthaScreen method from Invitrogen. Compounds were assayed at a maximum concentration of 10 μmol/L in the presence of 1 μmol/L ATP, and IC50 values were determined using GraphPad Prism software.
Cell Research:[2]
- Collapse
  • Cell lines: U87MG cells
  • Concentrations: 0.5 μM
  • Incubation Time: 24 hours
  • Method: U87MG cells are treated with PI-103 for 24 hours. Cell death is quantified by colorimetric determination of LDH activity using a cytotoxicity detection kit. Percentage of cell death (mean of three 12-well plates per experimental point) is calculated [(experimental value- low control)/(high control -low control) × 100], where the low-control cells are DMSO treated and high-control cells are Triton treated (1% Triton X-100, 30 min, 37 °
    (Only for Reference)
Animal Research:[2]
- Collapse
  • Animal Models: 6- to 12-week-old Balbc nu/nu mice bearing U87MG:ΔEGFR cells
  • Dosages: 5 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 24 mg/mL (68.89 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O
For best results, use promptly after mixing.
1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.36
Formula

C19H16N4O3

CAS No. 371935-74-9
Storage powder
in solvent
Synonyms N/A
Smiles C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy PI-103 | PI-103 supplier | purchase PI-103 | PI-103 cost | PI-103 manufacturer | order PI-103 | PI-103 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID