Emamectin Benzoate

Catalog No.S4423 Synonyms: EMB, MK-244

For research use only.

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.

Emamectin Benzoate Chemical Structure

CAS No. 155569-91-8

Purity & Quality Control

Choose Selective GABA Receptor Inhibitors

Other GABA Receptor Products

Biological Activity

Description Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
Targets
GABA transporter [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(99.18 mM)
Water Insoluble
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1008.24
Formula

C56H81NO15

CAS No. 155569-91-8
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05081739 Not yet recruiting Diagnostic Test: Prospera Transplant Assessment Heart Transplant Failure and Rejection Natera Inc. January 2022 Not Applicable
NCT05176665 Recruiting Drug: EMB-01 Neoplasms|Neoplasm Metastasis|Metastatic Gastrointestinal Carcinoid Tumor Shanghai EpimAb Biotherapeutics Co. Ltd.|Covance October 21 2021 Phase 1|Phase 2
NCT04735575 Recruiting Biological: EMB-06 Relapsed or Refractory Multiple Myeloma Shanghai EpimAb Biotherapeutics Co. Ltd. May 20 2021 Phase 1|Phase 2
NCT04618393 Recruiting Biological: EMB-02 Advanced Solid Tumors Shanghai EpimAb Biotherapeutics Co. Ltd. March 11 2021 Phase 1|Phase 2
NCT04085718 Unknown status -- Myocarditis Medical University of Warsaw September 2019 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Emamectin Benzoate | Emamectin Benzoate supplier | purchase Emamectin Benzoate | Emamectin Benzoate cost | Emamectin Benzoate manufacturer | order Emamectin Benzoate | Emamectin Benzoate distributor