Home Neuronal Signaling GABA Receptor activator - DNA/RNA Synthesis activator - Apoptosis related activator Emamectin Benzoate For research use only.

Emamectin Benzoate

Synonyms: EMB, MK-244

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.

Emamectin Benzoate Chemical Structure

Emamectin Benzoate Chemical Structure

CAS: 155569-91-8

Purity & Quality Control

Batch: S442301 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 99.24%
99.24

Emamectin Benzoate Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

Choose Selective GABA Receptor Inhibitors

Biological Activity

Description Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
Targets
GABA transporter [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05661266 Recruiting
Multiple Sclerosis
Innodem Neurosciences
 August 16 2023 --
NCT05498389 Not yet recruiting
Metastatic Lung Non-Small Cell Carcinoma|Advanced Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|EGFR Mutation-Related Tumors
Shanghai EpimAb Biotherapeutics Co. Ltd.|Labcorp Corporation of America Holdings Inc
 June 2023 Phase 1|Phase 2
NCT05607498 Recruiting
Advanced/Metastatic Solid Tumors|Relapse/Refractory Lymphoma
EpimAb Biotherapeutics (Suzhou)Co. Ltd.
 March 1 2023 Phase 1
NCT05263180 Recruiting
Advanced Solid Tumor
Shanghai EpimAb Biotherapeutics Co. Ltd.
 July 25 2022 Phase 1
NCT05375279 Not yet recruiting
Amyloidosis
Unity Health Toronto|Pfizer
 June 15 2022 --

Chemical Information & Solubility

Molecular Weight 1008.24 Formula

C56H81NO15
CAS No. 155569-91-8 SDF --
Smiles CCC(C)C1OC2(CC3CC(C\C=C(C)\C(OC4CC(OC)C(OC5CC(OC)C(NC)C(C)O5)C(C)O4)C(C)/C=C/C=C/6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C.OC(=O)C8=CC=CC=C8
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (99.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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