Home Neuronal Signaling GABA Receptor activator Emamectin Benzoate

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Emamectin Benzoate GABA Receptor activator

Cat.No.S4423

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. This compound induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
Emamectin Benzoate GABA Receptor activator Chemical Structure

Chemical Structure

Molecular Weight: 1008.24

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Quality Control

Batch: S442301 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.24%
99.24

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (99.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 1008.24 Formula

C56H81NO15

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 155569-91-8 -- Storage of Stock Solutions

Synonyms EMB, MK-244 Smiles CCC(C)C1OC2(CC3CC(C\C=C(C)\C(OC4CC(OC)C(OC5CC(OC)C(NC)C(C)O5)C(C)O4)C(C)/C=C/C=C/6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C.OC(=O)C8=CC=CC=C8

Mechanism of Action

Targets/IC50/Ki
GABA transporter
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06283524 Not yet recruiting
Multiple Sclerosis
Innodem Neurosciences
 March 18 2024 --
NCT05661266 Recruiting
Multiple Sclerosis
Innodem Neurosciences
 August 16 2023 --
NCT05498389 Not yet recruiting
Metastatic Lung Non-Small Cell Carcinoma|Advanced Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|EGFR Mutation-Related Tumors
Shanghai EpimAb Biotherapeutics Co. Ltd.|Labcorp Corporation of America Holdings Inc
 June 2023 Phase 1|Phase 2
NCT05607498 Recruiting
Advanced/Metastatic Solid Tumors|Relapse/Refractory Lymphoma
EpimAb Biotherapeutics (Suzhou)Co. Ltd.
 March 1 2023 Phase 1

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