Doxorubicin (Adriamycin) HCl

For research use only. Not for use in humans.

Licensed by Pfizer Catalog No.S1208 Synonyms: NSC 123127

611 publications

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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Selleck's Doxorubicin (Adriamycin) HCl has been cited by 611 publications

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets
Topo II [1]
(Tumor cells)
In vitro

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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NCI-H226 MXzDfZRwfG:6aXOgRZN{[Xl? M4e1dFExOCEQvF2= NUXHTmdTPDhiaB?= NXf0V49oT0l3ME2wMlA2KM7:TR?= NIjZSHAzOzh5MUmwOS=>
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MDA-MB-231 M13WOWZ2dmO2aX;uJGF{e2G7 NIDSWoY2KM7:TR?= NGX6dGkzPCCq MljOR4VtdHWuYYKgeZB1[Wun M4DLTlI{QTd|MkGz
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MRC5 NHG4U21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX23NkBp MVHJR|UxRTBwMTFOwG0> MXGyOFAzOTR4Mh?=
HUVEC NV\NWWJ7TnWwY4Tpc44hSXO|YYm= M2m0SFUh|ryP NYC0R|huOiCq NVn3O2k6S2WubIXsZZIhfXC2YXvl NUjpNZlsOjRyMki0OFY>
MDA-MB-435 M1fBNmN6fG:2b4jpZ{BCe3OjeR?= NXfjR3M3OTByIN88US=> MoO2OFghcA>? M3;uNGlEPTB;MD6xOUDPxE1? MYeyOFAzQDR2Nh?=
AS49-RAW NIPVeZdEgXSxdH;4bYMhSXO|YYm= MmKxNVAxKM7:TR?= NGXwRlA1QCCq MW\JR|UxRTN{Lke4JO69VQ>? NYW5SVN5OjRyN{e1Nlg>
Caov3 NIK4ZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHBS4YyPzJiaB?= M3vwcGlEPTB;MD6xJO69VQ>? NFTCNWszPDB7NUC4PS=>
LNcaP MnGySpVv[3Srb36gRZN{[Xl? NGPxSlg{KM7:TR?= M3y2e|I1KGh? MYTJcoNz\WG|ZTDv[kBkdGWjdnXkJINie3Cjc3WtPUBt\X[nbB?= MXGyOFA6PTB6OR?=
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OVCAR8 NVXnOYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOyNEDPxE1? M4DIe|czKGh? NYLBblBJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> NVO1[nlnOjRyOUWwPFk>
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Caco2 MlHER5l1d3SxeHnjJGF{e2G7 NFraS4s1OCEQvF2= NXvFVIlYOjRiaB?= Mn3xR5l1d3SxeHnjbZR6 NUDxNWtrOjRyOUm5PVQ>
MDA-MB-468 M3\KfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XiNVExKM7:TR?= NH7WelQ4OiCq M3vi[GdKPTB;MD6wPFUh|ryP M3;OfFI1OTZ|N{K5
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MKN28 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy0PEBp NIH5U2hIUTVyPUCuNlQh|ryP MkThNlQyQDRyN{[=
SGC7901 NVWwNHp1S3m2b4TvfIlkKEG|c3H5 NWDmTJNvUUN3ME2wMlAyOSEQvF2= MkHDNlQyQTV2Nk[=
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CHP100 NYjWZWo6S3m2b4TvfIlkKEG|c3H5 MVO3NkBp MXHJR|UxRTBwN{mg{txO NWjGUG1tOjR{NUG0NVc>
MGC803 NFXWPXVEgXSxdH;4bYMhSXO|YYm= MmrMO|IhcA>? NHnFOXZKSzVyPUCuNVch|ryP M3\S[|I1OzdyMUG0
ME180 M3PCTWN6fG:2b4jpZ{BCe3OjeR?= MnW4OFghcA>? MWjJR|UxRTBwM{mg{txO MVmyOFQ5PzF6OB?=
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CAL-33 M1fjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fwb2lEPTB;NkeuPFchdk1? NVSwVXFqW0GQR1XS
MC-IXC NG\BVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTRTWM2OD14Nz65JI5O NU\OcXlJW0GQR1XS
CPC-N M1L5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZ6LkSgcm0> NGnxV|ZUSU6JRWK=
A2780 M3jt[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZ6Lke5JI5O NG\EPXRUSU6JRWK=
Daudi NFvZfW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPvRmZKSzVyPU[4Mlk3KG6P NHnRenVUSU6JRWK=
GI-1 NYfYXmM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF30UFJKSzVyPU[5MlY2KG6P NInMemVUSU6JRWK=
SW962 M1rNbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG4dFZKSzVyPU[5Mlk2KG6P M{f4e3NCVkeHUh?=
MFE-296 NF3SfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPyXZNxUUN3ME23NE41QSCwTR?= MmPxV2FPT0WU
H4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnrW3hSUUN3ME23NU42PiCwTR?= MlH1V2FPT0WU
AN3-CA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;xOmlEPTB;N{KuN|Ihdk1? MorlV2FPT0WU
HCC1599 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTd{LkW0JI5O NFjLSYJUSU6JRWK=
HuCCT1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTd{LkmzJI5O MXnTRW5ITVJ?
Calu-1 NFO3fGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zHfWlEPTB;N{OuOkBvVQ>? NHjXOIxUSU6JRWK=
DU-145 NUX6XZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTd|LkezJI5O MkfqV2FPT0WU
IST-SL2 NUe4cY1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HX[mlEPTB;N{OuPFEhdk1? M3TyR3NCVkeHUh?=
HSC-3 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL3UY5KSzVyPUe0MlU{KG6P NVvYV2JSW0GQR1XS
HCC1806 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e3W2lEPTB;N{SuPVYhdk1? MVzTRW5ITVJ?
VM-CUB-1 NIHJUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTqTWM2OD15NT6zOkBvVQ>? MmjIV2FPT0WU
HSC-4 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTd3Lke2JI5O MYTTRW5ITVJ?
NH-12 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfBTWM2OD15NjDuUS=> NWPjN3BjW0GQR1XS
MDA-MB-468 NIXPclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofHTWM2OD15Nj6xPEBvVQ>? NUDvTlMxW0GQR1XS
TUR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X3c2lEPTB;N{[uN|Ihdk1? M4TqVHNCVkeHUh?=
TE-1 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTd4LkO1JI5O NELkRXBUSU6JRWK=
CMK MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTd5LkSyJI5O MoXrV2FPT0WU
LB996-RCC NVrFXXlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTd6LkS1JI5O MorVV2FPT0WU
NCI-H1650 NXH5V2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\IWGNKSzVyPUe4MlYzKG6P M{\zVXNCVkeHUh?=
DMS-273 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDB[YxKSzVyPUe4Mlkhdk1? NWfNZmkyW0GQR1XS
NOS-1 NXnENlNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M321XmlEPTB;N{muNVQhdk1? MkjhV2FPT0WU
NB69 M1P4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLiTWM2OD15OT6yJI5O M1j6NnNCVkeHUh?=
SUP-T1 M{XuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37lNGlEPTB;N{muO|Ihdk1? NVm4b4ZPW0GQR1XS
A172 NWXPTod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXTTm42UUN3ME24NE42PSCwTR?= NUKxWlZqW0GQR1XS
TE-12 NInKXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRThzLkC2JI5O NWLSV3VEW0GQR1XS
MKN45 NWXFfmNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf6cJZrUUN3ME24NU42OSCwTR?= MWfTRW5ITVJ?
LoVo NFvKVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXkWo51UUN3ME24NU45OiCwTR?= MnfNV2FPT0WU
SW1573 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvrUZNKSzVyPUiyMlgyKG6P Mn\4V2FPT0WU
ETK-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITQeHRKSzVyPUizMlAyKG6P NFT1U4xUSU6JRWK=
ABC-1 NVHZdI5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LhcGlEPTB;OEOuOFUhdk1? MlPjV2FPT0WU
COLO-668 NWXi[mJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLNdGRKSzVyPUi0MlQ4KG6P NYDJS|VYW0GQR1XS
UM-UC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3PTWM2OD16Nj6wNkBvVQ>? NFrkT2ZUSU6JRWK=
BC-1 NYLDZ5g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XUc2lEPTB;OE[uO|Yhdk1? M3q5[HNCVkeHUh?=
PANC-10-05 NXrNNFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTh6LkS1JI5O NVLQbpM2W0GQR1XS
ES3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS0b3JOUUN3ME24PU41QCCwTR?= MYnTRW5ITVJ?
TE-441-T M4HxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\uTWM2OD16OT64NkBvVQ>? MlX5V2FPT0WU
KM-H2 M{DwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnaW2xKSzVyPUmwMlY5KG6P MlXlV2FPT0WU
SH-4 NWfvfINiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP5SGpjUUN3ME25Nk4yOSCwTR?= M3PmRnNCVkeHUh?=
SF268 NXHGPIdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrjTWM2OD17Mj60NkBvVQ>? NWKwNJFnW0GQR1XS
VMRC-RCZ M1nmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zUZmlEPTB;OUOuNlYhdk1? NWDENYRlW0GQR1XS
GI-ME-N MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXLUoZKSzVyPUmzMlM{KG6P NU\VNpM2W0GQR1XS
JEG-3 NV3ES246T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\PTWM2OD17NT6xNkBvVQ>? NHjQR|ZUSU6JRWK=
J-RT3-T3-5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\pW2lEPTB;OU[uN|Ehdk1? NXr1Wll7W0GQR1XS
K5 NUDzPIhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7LPXRKSzVyPUm2Mlkhdk1? MX;TRW5ITVJ?
EFO-27 MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDMS25[UUN3ME25O{41PCCwTR?= NX\lbJQ4W0GQR1XS
SW1783 NIX1TnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjjbW8{UUN3ME25O{46QSCwTR?= MVnTRW5ITVJ?
CAL-39 M2HhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTl6LkK0JI5O NXTLcZBnW0GQR1XS
LS-441N NXqwUWFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTl7LkC2JI5O MVXTRW5ITVJ?
G-402 M2jlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX1OHpKSzVyPUm5MlA6KG6P NEPLXJNUSU6JRWK=
MES-SA NXjDTXJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfEU2lKSzVyPUm5MlU{KG6P MnO4V2FPT0WU
FADU M3f0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLYdGVKSzVyPUGwNk4yQCCwTR?= MVnTRW5ITVJ?
DJM-1 NHXVclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHLTWM2OD1zMEKuNlUhdk1? NVrOT3poW0GQR1XS
SU-DHL-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGewW2pKSzVyPUGwNk42KG6P NUSwVoljW0GQR1XS
KYSE-410 NYXtWnFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljkTWM2OD1zMEOuOFYhdk1? NI\VV2FUSU6JRWK=
NCI-H1618 M2j1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[1doRKSzVyPUGwOE4{PSCwTR?= M{HXRnNCVkeHUh?=
AU565 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjwVXF[UUN3ME2xNFQvPTFibl2= MVfTRW5ITVJ?
SF126 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjiU|FKSzVyPUGwOE42QCCwTR?= MWDTRW5ITVJ?
MMAC-SF M{\aPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zadWlEPTB;MUC2MlQ5KG6P MoKzV2FPT0WU
ChaGo-K-1 M{PLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XWRWlEPTB;MUC3Mlk2KG6P NYjhZYRMW0GQR1XS
NCI-H596 M3nHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTNWphJUUN3ME2xNFgvODFibl2= NF\EeG9USU6JRWK=
LXF-289 NFLxVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r0W2lEPTB;MUC5MlI1KG6P NELmOGlUSU6JRWK=
HCC1569 NXnNNHJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFyOT6zOEBvVQ>? NH:wUmZUSU6JRWK=
NCI-H2170 MkPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXwcXJKSzVyPUGwPU46OiCwTR?= NYrCR4J2W0GQR1XS
ARH-77 M4L1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13BSmlEPTB;MUC5Mlk6KG6P Ml7LV2FPT0WU
BOKU NVjN[HFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHywd|VKSzVyPUGxNE45PyCwTR?= NHXTU2VUSU6JRWK=
SJSA-1 NGTnSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH60bFJKSzVyPUGxNU4xPSCwTR?= MUjTRW5ITVJ?
SW626 NEPwb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPYOINxUUN3ME2xNVEvPzFibl2= NIPo[ZpUSU6JRWK=
EHEB NX;PS3YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17LRWlEPTB;MUGyMlU6KG6P MUXTRW5ITVJ?
TE-10 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjsfJdQUUN3ME2xNVIvPjhibl2= NIT6TJFUSU6JRWK=
MZ7-mel NXHGOW84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXhd2JKSzVyPUGxNk45PCCwTR?= NIjIV|BUSU6JRWK=
SAS NWTXXVVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3tTWM2OD1zMUSuOFUhdk1? NFvrXYpUSU6JRWK=
TK10 NUP5RXZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXuR2lKSzVyPUGxOE43KG6P NUSwVlNlW0GQR1XS
SW13 M2LqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qyWGlEPTB;MUG1MlI3KG6P M{L0fXNCVkeHUh?=
HCC1937 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjtXXhKSzVyPUGxOU45PCCwTR?= M2rwPHNCVkeHUh?=
SK-NEP-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T1cWlEPTB;MUG2MlI3KG6P M1vPeHNCVkeHUh?=
OVCAR-5 M4\6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFzNj64NUBvVQ>? NYXxOG9EW0GQR1XS
SW837 M3X3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nQOWlEPTB;MUG3Mlk2KG6P M{TWRnNCVkeHUh?=
BFTC-909 NH\yUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvjT3RKSzVyPUGxPE41QCCwTR?= M1jCU3NCVkeHUh?=
SW872 M4\0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF{MD64NUBvVQ>? MoO3V2FPT0WU
SF539 NEm4T5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfDT4xZUUN3ME2xNlEvPzJibl2= NXPJNoxUW0GQR1XS
MLMA NVXnTllXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP6TWM2OD1zMkKuNFghdk1? MWnTRW5ITVJ?
BL-41 NXnqbohyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvwU3lKSzVyPUGyNk4zOiCwTR?= NHjSVGlUSU6JRWK=
LB647-SCLC NIDGOYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF{Mz6zOUBvVQ>? NGqwNZBUSU6JRWK=
NCI-H1703 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH0NXZKSzVyPUGyOk41OiCwTR?= NHXVcXFUSU6JRWK=
KURAMOCHI NULldHpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DvPWlEPTB;MUK2Mlc3KG6P NGP6fIhUSU6JRWK=
ATN-1 NHXiZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LiVmlEPTB;MUK3Mlchdk1? NGqx[mtUSU6JRWK=
SK-CO-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;rNlRKSzVyPUGyPU4zOSCwTR?= M{DQ[3NCVkeHUh?=
RPMI-7951 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm5TWM2OD1zM{CuNVQhdk1? M1PnN3NCVkeHUh?=
NCI-H1648 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF|MT65OEBvVQ>? NF3LOFlUSU6JRWK=
NCI-H64 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TFfWlEPTB;MUOyMlY2KG6P MnzYV2FPT0WU
HT-3 NEHSdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK4TWM2OD1zM{OuNFQhdk1? NYi4[IhCW0GQR1XS
NCI-H1770 M4G5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLHTWM2OD1zM{OuNlEhdk1? MoXmV2FPT0WU
NB13 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknYTWM2OD1zM{SuOVUhdk1? MlrTV2FPT0WU
NCI-H747 NECyTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ToOWlEPTB;MUO1MlAzKG6P NEiyR5dUSU6JRWK=
ML-2 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF|NT6xOkBvVQ>? MYDTRW5ITVJ?
CA46 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP0TWM2OD1zM{[uPFghdk1? NUGycmVSW0GQR1XS
ES6 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj4VVRDUUN3ME2xN|cvOTJibl2= NHHNZmlUSU6JRWK=
JiyoyeP-2003 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jCe2lEPTB;MUO3Mlghdk1? M{H1SHNCVkeHUh?=
NMC-G1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF|OT6xN{BvVQ>? MkPYV2FPT0WU
U-698-M M{TZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyyTWM2OD1zM{muOUBvVQ>? M4XZNXNCVkeHUh?=
LU-99A Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf3TWM2OD1zNE[uOVUhdk1? M{fj[nNCVkeHUh?=
NCI-H748 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jYXWlEPTB;MUS3MlMyKG6P MYjTRW5ITVJ?
SK-MEL-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHtVYRKSzVyPUG0O{43OSCwTR?= MluxV2FPT0WU
SNB75 NULZS2U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;rTWM2OD1zNEiuOlUhdk1? MlrZV2FPT0WU
BB65-RCC NXLyN5BzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz1U4xKSzVyPUG0PU4{OSCwTR?= MYjTRW5ITVJ?
NCI-H1355 NIfW[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\yWotYUUN3ME2xOVIvOjRibl2= NISw[lNUSU6JRWK=
SCC-25 NGfuZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF3Mz63N{BvVQ>? M3mxdXNCVkeHUh?=
OAW-42 NV\ibWprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nqb2lEPTB;MUWzMlg1KG6P M{DFZnNCVkeHUh?=
MONO-MAC-6 M3\2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzlVJZXUUN3ME2xOVQvOzZibl2= NWHLN2VjW0GQR1XS
WSU-NHL NUnOV|F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33VdWlEPTB;MUW0MlU5KG6P NGXCTW9USU6JRWK=
SNU-423 M1jkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr3UYd2UUN3ME2xOVUvOzRibl2= M3\2N3NCVkeHUh?=
SBC-1 NEPaN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW0eGxDUUN3ME2xOVYvPCCwTR?= NVHDTINDW0GQR1XS
OVCAR-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvVTWM2OD1zNU[uO|ghdk1? MWTTRW5ITVJ?
NCI-H2347 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPkfWdDUUN3ME2xOVgvOzRibl2= MVXTRW5ITVJ?
CAMA-1 NG\1bWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\TNFNKSzVyPUG1PU4{OyCwTR?= MWPTRW5ITVJ?
GDM-1 NETPPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF3OT63JI5O Moq3V2FPT0WU
KNS-81-FD MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\WZmlLUUN3ME2xOlAvOzJibl2= NUXaOJdVW0GQR1XS
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CP66-MEL NH7uR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwMEG3Olch|ryP MV\TRW5ITVJ?
Hs-578-T NIDlXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\ZOmlEPTB;Mj6wNVc5OiEQvF2= NHfj[WdUSU6JRWK=
HCC70 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwMEW0OlMh|ryP MoT4V2FPT0WU
SW1088 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLHTWM2OD1{LkC2PVMyKM7:TR?= NGnWXnVUSU6JRWK=
NB6 M2jzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\1[GlEPTB;Mj6xPFUh|ryP NXXSTYVQW0GQR1XS
KU-19-19 NVPBe45YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJwMk[5NVch|ryP MlPHV2FPT0WU
A704 NHXLbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDD[olKSzVyPUKuNlkyOzVizszN NFXGUlhUSU6JRWK=
EVSA-T NXfROlF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT6TWM2OD1{LkOwNFg6KM7:TR?= NXjPeJlZW0GQR1XS
HCT-15 M3;BTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPwVHpKSzVyPUKuN|U1PjZizszN NF[1VVRUSU6JRWK=
HuO-3N1 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HWTmlEPTB;Mj6zOlU5OyEQvF2= M{[wU3NCVkeHUh?=
GMS-10 M4[ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwM{m3N|gh|ryP Ml76V2FPT0WU
TGBC24TKB NXLGNHk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWTWM2OD1{LkSxOFI6KM7:TR?= NECxeIdUSU6JRWK=
C2BBe1 NE[1dJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITnfWlKSzVyPUKuOVE{OjhizszN NXr4RXc3W0GQR1XS
SK-N-DZ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJwNU[1PVIh|ryP MkjnV2FPT0WU
SK-N-AS NX3OenVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwN{OwNVUh|ryP MYfTRW5ITVJ?
T98G MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJTWM2OD1{LkiwOFAyKM7:TR?= M3j6d3NCVkeHUh?=
DMS-79 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mwbGlEPTB;Mj65NFk5QCEQvF2= NEXwTIdUSU6JRWK=
SNU-475 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKyTWM2OD1{LkmyOVczKM7:TR?= M{nwPHNCVkeHUh?=
COLO-792 M3OxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMEK4O{DPxE1? NH3KR4xUSU6JRWK=
YAPC NVvVZlFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwM{K4N|Ih|ryP MVvTRW5ITVJ?
UACC-812 NI\m[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrZWYhCUUN3ME2zMlM{PzN6IN88US=> NVP3dGdEW0GQR1XS
Mewo NFTKVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zL[WlEPTB;Mz60OlA5PiEQvF2= M17KZnNCVkeHUh?=
COLO-824 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTNwNUezO|gh|ryP MoWwV2FPT0WU
SCC-9 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwOUGzNFkh|ryP M{HwVXNCVkeHUh?=
CP50-MEL-B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnobmtKSzVyPUOuPVg4ODNizszN MVXTRW5ITVJ?
NCI-H345 NInBTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRwMEGxO|Qh|ryP M4PKS3NCVkeHUh?=
COR-L88 NUfuemZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIroRYJKSzVyPUSuN|k2QCEQvF2= NYjlSnhHW0GQR1XS
RCM-1 M1j3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTRwNEmyO|Ih|ryP MnnBV2FPT0WU
JVM-3 M1u2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX0Xm84UUN3ME20MlYxPjF6IN88US=> M4XLOHNCVkeHUh?=
ECC4 NVTDXGRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfPN25KSzVyPUSuO|Y2PDFizszN M4PZVXNCVkeHUh?=
MDA-MB-453 NFnDcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XH[mlEPTB;ND64OVE{PCEQvF2= NXzoTlgyW0GQR1XS
SK-N-FI NH7odFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW3TWM2OD13LkKyPFc4KM7:TR?= NGHE[odUSU6JRWK=
D-502MG M4\1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTVwMkSyOlIh|ryP NYD5ZpQyW0GQR1XS
NCI-H2227 NUXFUWMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\TZ4FUUUN3ME21MlM3OjNzIN88US=> NGfOOoxUSU6JRWK=
DMS-53 NHi3ZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTZwMUexNFYh|ryP M3PoeHNCVkeHUh?=
LB771-HNC M3PjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvWTWM2OD14LkS2PFA3KM7:TR?= NXGycYMyW0GQR1XS
BB49-HNC NF3ydpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTdwNEG3PVEh|ryP NUe0WoZ4W0GQR1XS
MDA-MB-415 NUDRWZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTpZnNEUUN3ME23MlU4OzB|IN88US=> MVTTRW5ITVJ?
TALL-1 NXH4eYtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n3T2lEPTB;Nz65Olg5KM7:TR?= MVLTRW5ITVJ?
HCC1395 M2rCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITPSpJKSzVyPUiuNVUyOjJizszN NF;Je5BUSU6JRWK=
EFE-184 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKzTWM2OD16LkO3NlE3KM7:TR?= NWLObXhVW0GQR1XS
EC-GI-10 NGrI[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHvTWM2OD16Lk[4Olg3KM7:TR?= NIC4WJVUSU6JRWK=
TT MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r6TWlEPTB;OT6wOlk3PiEQvF2= Mo\SV2FPT0WU
U-2-OS M2nVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTlwOEGzPVMh|ryP MYrTRW5ITVJ?
SHP-77 NXHyS5FET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3iUZRKSzVyPUmuPVAzQSEQvF2= NYTBclN5W0GQR1XS
HCC1143 NVHPO2FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj5TmJKSzVyPUGwMlQ4QTdizszN NF3obXBUSU6JRWK=
A498 M4TFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fSTGlEPTB;MUiuNlk4PiEQvF2= MojyV2FPT0WU
LS-513 NH71SGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT3VVdiUUN3ME2xPE43ODl|IN88US=> NHmyOlBUSU6JRWK=
K052 NULMdo5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnsUXVKSzVyPUKxMlQ1OThizszN Ml:5V2FPT0WU
SiHa NUPxT3oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjEWG9KSzVyPUKzMlM{PzFizszN M{TqOHNCVkeHUh?=
RCC10RGB NIfzenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTNyLkC2NVEh|ryP Mn3JV2FPT0WU
NCI-SNU-16 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULzbW53UUN3ME2zNU4yQDN4IN88US=> MX7TRW5ITVJ?
SNU-C1 M1nXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K5O2lEPTB;M{KuOFE4PSEQvF2= M17YVnNCVkeHUh?=
C32 NEW3VI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nDR2lEPTB;M{KuPFczKM7:TR?= NE\uO4hUSU6JRWK=
SW684 NXz0bGw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljITWM2OD1|ND6xOVYyKM7:TR?= M4fJdXNCVkeHUh?=
SK-MEL-28 M163e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN3LkWzO|ch|ryP MV;TRW5ITVJ?
SK-MEL-1 MoDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi2TWM2OD1|Nj63OVQ4KM7:TR?= NYDqfWJoW0GQR1XS
NCI-H720 M2XCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LD[2lEPTB;NEGuPVczPiEQvF2= MnPTV2FPT0WU
P31-FUJ NFLyOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjsSmtKSzVyPUS0MlMzQDRizszN NILlNG1USU6JRWK=
NCI-H524 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ft[WlEPTB;NEiuPFI1QCEQvF2= MnP3V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
POU5F1 / SOX2 / NANOG; 

PubMed: 27929731     


NT2/D1 cells treated with 10 nM of doxorubicin were subjected to WB analysis for pluripotency factors (POU5F1, NANOG, SOX2) and differentiation markers (TUBB3).

ATG5 / ATG7 / SQSTM1 / LC3A-II / LC3B-II / p-mTOR; 

PubMed: 27929731     


NT2/D1 cells treated with 10 nM of doxorubicin were subjected to WB analysis for autophagy markers (ATG5, ATG7, SQSTM1, LC3A-II, LC3B-II and p-MTOR). 

P62 / LC3II; 

PubMed: 28208617     


(A,B) Doxorubicin induces autophagy in pancreatic cancer cells. Western blot analysis of LC3-II and p62 protein levels in Mia PaCa-2 and Panc-1 cell lines treated with indicated concentrations of doxorubicin for 24 h, or treated with 2.5 μM doxorubicin for indicated times.

p-AKT(T308) / p-Akt(S473) / Akt / p-PRAS40(T246) / PRAS40 / p-H2A.X(S139); 

PubMed: 26027929     


MCF10A cells were serum-starved and treated with (A) 2 μM doxorubicin over a 10 hour time course.

27929731 28208617 26027929
Growth inhibition assay
Cell viability; 

PubMed: 25871400     


Salinomycin enhances the cytotoxicity of doxorubicin in HCC cellsRelative cell viability (mean ± SD) for salinomycin (black), doxorubicin (blue) and doxorubicin plus salinomycin (red) in HuH-7, HepG2, SNU-449 and SNU-387 cells.

25871400
Immunofluorescence
LC3; 

PubMed: 24970805     


Doxorubicin induces GFP-LC3 puncta formation in hepatocellular carcinoma cells. SK-Hep1 cells were treated with doxorubicin (2.5 μM) or CQ (10 μM) plus doxorubicin for 7 h and cells were examined with a confocal microscope for GFP-LC3 punctuation/aggregation.

24970805
ELISA
OPN; 

PubMed: 24963635     


A549 were exposed to 50 nM doxorubicin or PBS for 48 h. OPN concentrations in cell culture media were determined by ELISA.

24963635
In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Female athymic nude mice injected s.c. with MB231 cells
  • Formulation: Dissolved in DMSO, and diluted in saline
  • Dosages: 3 mg/kg/day
  • Administration: Delivered intratumorly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage powder
in solvent
Synonyms NSC 123127
Smiles Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04032964 Not yet recruiting Drug: L19TNF|Drug: DOXORUBICIN Soft Tissue Sarcoma Philogen S.p.A. September 2019 Phase 1
NCT03975205 Not yet recruiting Drug: Doxorubicin Lymphoma Leukemia Sutphin Drugs|Bharath Charitable Cancer Hospital and Institute July 1 2019 Early Phase 1
NCT03591276 Recruiting Drug: Chemotherapy Drugs Cancer Metastatic Breast Cancer Shaare Zedek Medical Center April 18 2019 Phase 1|Phase 2
NCT03719430 Recruiting Drug: Doxorubicin|Drug: APX005M Soft Tissue Sarcoma Columbia University|Apexigen Inc. March 20 2019 Phase 2
NCT03059615 Recruiting Drug: Nerofe|Drug: Doxorubicin Acute Myelogenous Leukemia|Myelodysplastic Syndromes Immune System Key Ltd October 25 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Why the IC50 of the compound varied over time in our measurement?

  • Answer:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID