Doxorubicin (Adriamycin) HCl

Licensed by Pfizer Catalog No.S1208 Synonyms: NSC 123127

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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Cited by 36 Publications

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  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

     

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets
Topo II [1]
(Tumor cells)
In vitro

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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PC14 MW\DfZRwfG:6aXOgRZN{[Xl? NICxelI1KGR? NVvGPXhnTE2VTx?= MVHJR|UxRTBwMkmg{txO MonSPVgzOjV2Mh?=
HOP62 NVXXb|VPS3m2b4TvfIlkKEG|c3H5 NUmyXY5XPzJiaB?= NGPpO25KSzVyPUCuNFA1KM7:TR?= M1\pOVk5PzN4NkG=
SF-295 NVSwfZdsS3m2b4TvfIlkKEG|c3H5 NH6zZYc4OiCq MXHJR|UxRTBwMEO1JO69VQ>? MXK5PFc{PjZz
MDA-MB-361 M4P6fWN6fG:2b4jpZ{BCe3OjeR?= MkTXNUBp M{jJXWROW09? NUXD[nJUS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBMW1DNTN4MTDlfJBz\XO|aX7nJGxi[1pid3n0bEBKSzVyIH;mJFAvODF{IN88US=> M2DQOVExOzl3NEmw
MDA-MB-361 M4\ZdGN6fG:2b4jpZ{BCe3OjeR?= MoXRNUBp MWLEUXNQ NXvN[VMzS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0> NU\LVVhVOTB|OUW0PVA>
CCRF-SB NFLzcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVi0JIQ> NGnL[GlFVVOR M1z1VWlEPTB;MD6wNUDPxE1? MlfWNVA1OTF2N{[=
CHO-K1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXi0JIQ> NUTYTHd7TE2VTx?= M2HEfGlEPTB;MD60JO69VQ>? MlXMNVA1OTF2N{[=
KB MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVG0JIQ> NX:5ZZJKTE2VTx?= NWK0N5VmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRldFKHerdHigTWM2OCCxZjCwMlY2KM7:TR?= NUi4cWxGOTB2MUG0O|Y>
KB MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;yXmg1KGR? M1v3UWROW09? MoX3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQlPhcZB4cXSqIFnDOVAhd2ZiMD6wOkDPxE1? Mn62NVA1OTF2N{[=
KB NV\nTZpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS5OEBl MonsSG1UVw>? NV:5WJY4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRm1FWiC5aYToJGlEPTBib3[gNE42KM7:TR?= NYDxbJg2OTB2MUG0O|Y>
KB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTQbFN3PCCm M17yZmROW09? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEVkKwR{B4cXSqIFnDOVAhd2ZiMD60JO69VQ>? NFrTPG4yODRzMUS3Oi=>
HTB-54 MWjDfZRwfG:6aXOgRZN{[Xl? Mn7xNVAxKM7:TR?= MnK2TWM2OD1zLkGg{txO NWXhdG16OTB2N{[4OlE>
MEL-AC M1TRNGN6fG:2b4jpZ{BCe3OjeR?= NV[1bJlOOTByIN88US=> NX74XIxDUUN3ME2xMlIh|ryP NH7nV5kyODR5Nki2NS=>
DU145 NWHjW3VkS3m2b4TvfIlkKEG|c3H5 NXnHfJF2PzJiaB?= NYfMcYFnUUN3ME2wMlA2OjhizszN M2i1c|ExPDd7Mkiy
K562R M1rNPWN6fG:2b4jpZ{BCe3OjeR?= MoTVO|IhcA>? MXPJR|UxRTBwMEG1OkDPxE1? M{fyUlExPDd7Mkiy
PACA-2 NYLzT|RKS3m2b4TvfIlkKEG|c3H5 MYW2JIQ> Ml\PSWQ2OD1yLkCwOlMh|ryP M1K4eFExPDl6MkG0
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P388 MlHSR5l1d3SxeHnjJGF{e2G7 NVjDOmhxPzJiaB?= NGPufnVIUTVyPUCuNFEzKM7:TR?= NFrRTGEyODZ7MUexNC=>
HMV-1 NIjKdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHOTWM2OD1yLkK4JO69VQ>? M1r3c|ExPjl6NEO2
MKN-1 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH24cIhKSzVyPUCuOlQh|ryP M3\wclExPjl6NEO2
PC14 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXWTJVSUUN3ME2xMlkh|ryP MmLuNVA3QTh2M{[=
T24 M3;mWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD6cW5DUUN3ME2wMlY1KM7:TR?= MmHKNVA3QTh2M{[=
U937 NYS5XIVlTnWwY4Tpc44hSXO|YYm= NHfLV4kzPCCq NUjEO21{TE2VTx?= MUDJcohq[mm2czDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhf2m2aDDJR|UxKG:oIECuNUDPxE1? MYKxNFc5ODlzMR?=
H460pv8/eto M{TuO2N6fG:2b4jpZ{BCe3OjeR?= M1XDfVExOCEQvF2= MlToOFghcA>? NEe2UpRU[WyrbnW= MmTETWM2OD1yLkCyJO69VQ>? MXqxNFc5ODlzMx?=
H460pv8 MUfDfZRwfG:6aXOgRZN{[Xl? MYCxNFAh|ryP MYC0PEBp NVLOOoF1W2GuaX7l Mkn0TWM2OD1yLkCwOEDPxE1? MUmxNFc5ODlzMx?=
MDA-231 MYnDfZRwfG:6aXOgRZN{[Xl? NHjKR3kyODBizszN MVS0PEBp MWDTZYxqdmV? Mkj0R5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUKzNUBk\WyuIDjFVk0tTUeIUjuscZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFA3KM7:TR?= M2rF[VExPzhyOUGz
MDA-468 NHXPXnlEgXSxdH;4bYMhSXO|YYm= NGf0eYEyODBizszN MkPFOFghcA>? MlHCV4FtcW6n M1TwPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=> NFjBWocyODd6MEmxNy=>
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HCC70 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJwMEW0OlMh|ryP NWPSZ2ZsW0GQR1XS
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DMS-79 M4DOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwOUC5PFgh|ryP MonWV2FPT0WU
SNU-475 NULRb4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKwTWM2OD1{LkmyOVczKM7:TR?= M1z5XnNCVkeHUh?=
COLO-792 MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTTPHdJUUN3ME2zMlAzQDdizszN NIH2UHhUSU6JRWK=
YAPC NGHDT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\GTWM2OD1|LkOyPFMzKM7:TR?= M1vxd3NCVkeHUh?=
UACC-812 M2G4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH3TWM2OD1|LkOzO|M5KM7:TR?= M1[4VnNCVkeHUh?=
Mewo MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjMeVFRUUN3ME2zMlQ3ODh4IN88US=> MUHTRW5ITVJ?
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SCC-9 NHyxd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M335TGlEPTB;Mz65NVMxQSEQvF2= M1rqeXNCVkeHUh?=
CP50-MEL-B NWi4NJE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;URZE6UUN3ME2zMlk5PzB|IN88US=> MYTTRW5ITVJ?
NCI-H345 NGLRc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnxfpdpUUN3ME20MlAyOTd2IN88US=> NY\SPWRiW0GQR1XS
COR-L88 NV\LPIVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXKTWM2OD12LkO5OVgh|ryP NEDRcY1USU6JRWK=
RCM-1 NXHiNJhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\RTWM2OD12LkS5NlczKM7:TR?= M3;ROXNCVkeHUh?=
JVM-3 NIPFO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWyT4NKSzVyPUSuOlA3OThizszN MlrqV2FPT0WU
ECC4 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfiTWM2OD12Lke2OVQyKM7:TR?= NHXlOVlUSU6JRWK=
MDA-MB-453 NXj1eYNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnhZ4wxUUN3ME20Mlg2OTN2IN88US=> MnjCV2FPT0WU
SK-N-FI NGjzc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rleWlEPTB;NT6yNlg4PyEQvF2= MnzmV2FPT0WU
D-502MG NHfs[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlniTWM2OD13LkK0NlYzKM7:TR?= M3z3[HNCVkeHUh?=
NCI-H2227 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DPZWlEPTB;NT6zOlI{OSEQvF2= M3PlSXNCVkeHUh?=
DMS-53 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXsRlVsUUN3ME22MlE4OTB4IN88US=> M2HpeHNCVkeHUh?=
LB771-HNC NFLicFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i0b2lEPTB;Nj60OlgxPiEQvF2= MkHOV2FPT0WU
BB49-HNC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz1TWM2OD15LkSxO|kyKM7:TR?= NXfTOmZ[W0GQR1XS
MDA-MB-415 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK0e3E4UUN3ME23MlU4OzB|IN88US=> M{LVfnNCVkeHUh?=
TALL-1 MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjHU5piUUN3ME23Mlk3QDhizszN Mn;UV2FPT0WU
HCC1395 NFHp[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnMSZlKSzVyPUiuNVUyOjJizszN M3v0OXNCVkeHUh?=
EFE-184 M3i2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[xfJNwUUN3ME24MlM4OjF4IN88US=> MWXTRW5ITVJ?
EC-GI-10 M2jlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRThwNki2PFYh|ryP NWXm[|Z1W0GQR1XS
TT NXzHSmkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKwVHlKSzVyPUmuNFY6PjZizszN NFvSUmZUSU6JRWK=
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A498 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF6LkK5O|Yh|ryP MXjTRW5ITVJ?
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K052 NVfzT4g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn3OmhKSzVyPUKxMlQ1OThizszN MV7TRW5ITVJ?
SiHa MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWyTWM2OD1{Mz6zN|cyKM7:TR?= M2G1ZnNCVkeHUh?=
RCC10RGB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrVTWM2OD1|MD6wOlEyKM7:TR?= NV3sPGxoW0GQR1XS
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C32 M{K2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTN{Lki3NkDPxE1? NFy1TohUSU6JRWK=
SW684 M3zBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfaTXVNUUN3ME2zOE4yPTZzIN88US=> MnX5V2FPT0WU
SK-MEL-28 M3e0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT5c4JKSzVyPUO1MlU{PzdizszN NVqzTZI4W0GQR1XS
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P31-FUJ NF\uVo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHsTWM2OD12ND6zNlg1KM7:TR?= MWLTRW5ITVJ?
NCI-H524 M1X0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zFN2lEPTB;NEiuPFI1QCEQvF2= NGHIdFJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Female athymic nude mice injected s.c. with MB231 cells
  • Formulation: Dissolved in DMSO, and diluted in saline
  • Dosages: 3 mg/kg/day
  • Administration: Delivered intratumorly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage powder
in solvent
Synonyms NSC 123127

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL University of Chicago|Incyte Corporation September 5 2019 Phase 1
NCT03108300 Not yet recruiting Malignant Soft Tissue Sarcoma Ain Shams University August 30 2019 Phase 2
NCT03742986 Not yet recruiting Breast Cancer New York University School of Medicine April 2019 Phase 2
NCT03349281 Recruiting Refractory Acute Lymphoblastic Leukemia|Relapsed Acute Lymphoblastic Leukemia Julio Barredo|Takeda|University of Miami March 2019 Phase 1
NCT03331341 Not yet recruiting Classical Hodgkin Lymphoma University of Washington|National Cancer Institute (NCI) February 15 2019 Phase 2
NCT03669783 Not yet recruiting Childhood Renal Tumor Assistance Publique Hopitaux De Marseille January 1 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Why the IC50 of the compound varied over time in our measurement?

  • Answer:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase Signaling Pathway Map

Related Topoisomerase Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID