Doxorubicin (Adriamycin) HCl

Licensed by Pfizer Catalog No.S1208 Synonyms: NSC 123127

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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Cited by 100 Publications

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Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets
Topo II [1]
(Tumor cells)
In vitro

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 M4\MZ2Z2dmO2aX;uJGF{e2G7 MULJcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOge4l1cCCHREWwJI9nKDBwNUig{txO MoXTOFkxPTN4
Yoshida sarcoma MkPWSpVv[3Srb36gRZN{[Xl? MYnJcohq[mm2aX;uJI9nKFt|SG3U[HIhcW6lb4Lwc5JifGmxbjD3bZRpKEmFNUCgc4YhOC5yMjFOwG0> NIfRN2QyOzJ{OUi2
CHO NVjhS5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\p[2lEPTB;MD6wOkDPxE1? NHjLdIsyOzV2N{Ww
8226 M2iwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEOzJO69VQ>? MoTxNVQ1Pzd|MB?=
8226/ADR M4HUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnMPZFKSzVyPUCuOVYh|ryP MWixOFQ4PzNy
MCF7/ADR M2LZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnO1TWM2OD1|LkGg{txO MnHzNVQ1Pzd|MB?=
H69 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwOEeg{txO MVWxOFc6PTh3
N417 NVyyNIhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\VPWVKSzVyPUCuNlMh|ryP NWjpWVZ3OTR5OUW4OS=>
H9 M{HTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoOxTY5pcWKrdHnvckBw\iCKOTDj[YxteyClaILvcolk[WyueTDpcoZm[3SnZDD3bZRpKHSqZTDITXYuOSBqSEmvTWlKSilid3n0bEBKTDVyIH;mJFAvODFizszN NWntfI11OTV2OE[4NS=>
T-C8166 NWXocnJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLseG9KTDVyPUCuNFEh|ryP MmL1NVU1QDZ6MR?=
T-H9 NFXENHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLHTWQ2OD1yLkCxJO69VQ>? MnjlNVU1QDZ6MR?=
T-MT4 NFHE[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fze2lFPTB;MD6wNUDPxE1? NEDZXmUyPTR6Nkix
SKMEL-5 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfFSFUxRTNwMjFOwG0> MkPQNVYyOzd3Mx?=
MLM NVu2NYdyS3m2b4TvfIlkKEG|c3H5 Ml3ESWQ2OD1yLkGzJO69VQ>? M2\qPFE5PzV|NUC=
KBM-3 NH3q[IhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\Dc3ZKSzVyPUCuNFI3KM7:TR?= NGjNSYsyQTl3OEe3
HT-29 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2wMlAyKM7:Zx?= NWnHZndQPDhiaB?= MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?= NUXNdpViOjd5OES0PS=>
EMT6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\SS2xvOC53IN88US=> NEf2ZoEyKGh? Mor5TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJIJ6KG2nYYP1dolv\yCob4Kgd5Vzfmm4aX7nJIZz[WO2aX;ud{B4cXSqIFXEOVAhd2ZiMD6wNFAyKM7:TR?= M2P0bVc1PTJ4N{S=
H2981 M2O0ZWN6fG:2b4jpZ{BCe3OjeR?= MV3JR|UxRTBwNTFOwG0> MlLUO|c{OTB{Mx?=
LOX M4j5RWN6fG:2b4jpZ{BCe3OjeR?= M{fpV2lEPTB;MD6wOFIh|ryP MWW3PFU{OzNz
C38 NXjpbYw6S3m2b4TvfIlkKEG|c3H5 NEfzZ41KSzVyPUCuNFEh|ryP NHPvW4M5ODV5Mkmx
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A2780-C25 M3y3OGN6fG:2b4jpZ{BCe3OjeR?= M3rqTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG:6YXzpdIxifGmwLYLld4l{fGGwdDDBNlc5OC2FMkWge4l1cCCLQ{WwJI9nKDBwME[zJO69VQ>? M1zHWlg5OzF5NUW=
A2780-CP3 NWHIOYxES3m2b4TvfIlkKEG|c3H5 MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBkcXOybHH0bY4uemW|aYP0ZY51KEF{N{iwMWNROyC5aYToJGlEPTBib3[gNE4xPTZizszN MYq4PFMyPzV3
A2780-DX5 MYDDfZRwfG:6aXOgRZN{[Xl? M1rRd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLYLld4l{fGGwdDDBNlc5OC2GWEWge4l1cCCLQ{WwJI9nKDBwM{W3JO69VQ>? MW[4PFMyPzV3
MXF7 MkLMR5l1d3SxeHnjJGF{e2G7 NV;4RndJSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qhe2Wwc3n0bZZmKE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? NHHOZ3M5QTZyNUW4
MXF7 MVnDfZRwfG:6aXOgRZN{[Xl? M1zUWmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP MlXRPFk3ODV3OB?=
MXF7 MmTUR5l1d3SxeHnjJGF{e2G7 MlrVRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sg[I95d3K3YnnjbY4uemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDFwMUeyJO69VQ>? NVnDR2w3QDl4MEW1PC=>
WiDr NYrNPFhOS3m2b4TvfIlkKEG|c3H5 M2TQSWFkfGm4aYT5JIFo[Wmwc4Sgd4Vve2m2aY\lJHdqTHJiY3XscEB4cXSqIFnDOVAhd2ZiMD6wOVMh|ryP MY[4PVYxPTV6
MCF MmniSpVv[3Srb36gRZN{[Xl? NHj4TJdT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGG|c3Xzd4VlKGG|IHXubIFv[2WvZX70JIlvKGO7dH;0c5hq[2m2eTDv[kBi\HKrYX35Z4lv NEezO5Y5QTh2MUWx
C6 MWXDfZRwfG:6aXOgRZN{[Xl? M{faUFIvPSCvZz;tUC=> NF7kO5Y4OiCq NUnVTJdTTE2VTx?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRiQ{[gZ4VtdHNiYYSgOVAhfWdxbVygeI8hOi53IH3nM41N NUHHNWc5QDl6OE[wOC=>
C6 Mn;ISpVv[3Srb36gRZN{[Xl? M{\0eVIvPSCvZz;tUC=> NEXXcno1KGh? NYX0O3V4TE2VTx?= M{f5UmlvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvci=> NHTWc|A5QTh6NkC0
C6 NF\LcHFEgXSxdH;4bYMhSXO|YYm= NV3wVoZEOi53IH3nM41N NV\1O5N{PSCq NWXKXIQ2TE2VTx?= NILxcXZEgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOgZ4VtdCC{ZXzlZZNm M{LGUlg6QDh4MES=
SKVLB NEDVVHZEgXSxdH;4bYMhSXO|YYm= MmW5O|IhcA>? MnixTWM2OD14LkW0JO69VQ>? MUC5NFA{PTJy
MCF7/VP16 NXW2XYtoS3m2b4TvfIlkKEG|c3H5 M{HJTFUxKM7:Zz;tUC=> NYLpN|FvPzJiaB?= NF23N2VKSzVyPUG0MlIh|ryP Ml;MPVAzOjd7Mh?=
CA755 NVzLU5ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfJVWEyOCEQvF2= NFHkZpc3KGR? NV76OFdUUUN3ME2wMlAyPCEQvF2= NFrZeFk6PTJ4NUew
CHO M3frRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjFNngyOCEQvF2= NG\oWY83KGR? NVTWc45tUUN3ME2wMlA3KM7:TR?= M{XzOVk2OjZ3N{C=
Panc02 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHLNVAh|ryP MnG5OkBl NInYW4xKSzVyPUCuNFY2KM7:TR?= NV7PSXV2QTV{NkW3NC=>
PC14 M3jhSGN6fG:2b4jpZ{BCe3OjeR?= MmPyOEBl NYnQOopWTE2VTx?= MXvJR|UxRTBwMkmg{txO Ml\mPVgzOjV2Mh?=
HOP62 NHfsb2dEgXSxdH;4bYMhSXO|YYm= MmToO|IhcA>? MnK2TWM2OD1yLkCwOEDPxE1? M3nZfVk5PzN4NkG=
SF-295 MmDXR5l1d3SxeHnjJGF{e2G7 MWO3NkBp NHjwXJpKSzVyPUCuNFM2KM7:TR?= M1qw[lk5PzN4NkG=
MDA-MB-361 M1Tmc2N6fG:2b4jpZ{BCe3OjeR?= MVyxJIg> M3jVWmROW09? NYrhXZg6S3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBMW1DNTN4MTDlfJBz\XO|aX7nJGxi[1pid3n0bEBKSzVyIH;mJFAvODF{IN88US=> MnmxNVA{QTV2OUC=
MDA-MB-361 MkjJR5l1d3SxeHnjJGF{e2G7 M4LHN|EhcA>? NFW5ZXpFVVOR MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFiTVKgN|YyKGW6cILld5NqdmdiY3HyZo95gXCncITp[IF{\SC|dFPQS|Ihf2m2aDDJR|UxKG:oIECuNFE5KM7:TR?= MnjlNVA{QTV2OUC=
CCRF-SB Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfJc2s1KGR? M322[mROW09? NVj5cpRsUUN3ME2wMlAyKM7:TR?= MkHXNVA1OTF2N{[=
CHO-K1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHexfXg1KGR? NXXxWHNqTE2VTx?= M{jrUGlEPTB;MD60JO69VQ>? NX\HPIpYOTB2MUG0O|Y>
KB MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjGOEBl MoXaSG1UVw>? NVrDWHd5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRldFKHerdHigTWM2OCCxZjCwMlY2KM7:TR?= NWHVT4RlOTB2MUG0O|Y>
KB MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvqXnY1KGR? MoHlSG1UVw>? NYTk[XVOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= NXvpdGxFOTB2MUG0O|Y>
KB NIPFZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXIb2xZPCCm NIPwVoxFVVOR M1rHPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LNSHIhf2m2aDDJR|UxKG:oIECuOUDPxE1? NHXyT4oyODRzMUS3Oi=>
KB NELneZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDOEBl M4ThOGROW09? MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEVkKwR{B4cXSqIFnDOVAhd2ZiMD60JO69VQ>? NGfZXZIyODRzMUS3Oi=>
HTB-54 MUfDfZRwfG:6aXOgRZN{[Xl? MoHQNVAxKM7:TR?= M1rOc2lEPTB;MT6xJO69VQ>? NGnlclcyODR5Nki2NS=>
MEL-AC M1\Q[mN6fG:2b4jpZ{BCe3OjeR?= M2r2VFExOCEQvF2= MoTMTWM2OD1zLkKg{txO M3nJTFExPDd4OE[x
DU145 MnzKR5l1d3SxeHnjJGF{e2G7 M3nsXlczKGh? NUi0[JRDUUN3ME2wMlA2OjhizszN NGXSOFkyODR5OUK4Ni=>
K562R Mn[3R5l1d3SxeHnjJGF{e2G7 NVrjZohDPzJiaB?= MWjJR|UxRTBwMEG1OkDPxE1? MWOxNFQ4QTJ6Mh?=
PACA-2 NIPJTphEgXSxdH;4bYMhSXO|YYm= NYOyRmxjPiCm NYO3boRRTUR3ME2wMlAxPjNizszN M{K1[lExPDl6MkG0
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P388 M2OxfmN6fG:2b4jpZ{BCe3OjeR?= NInUW5Y4OiCq M3e0e2dKPTB;MD6wNVIh|ryP NF7qRlcyODZ7MUexNC=>
HMV-1 NIPCVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfkeWZKSzVyPUCuNlgh|ryP NVy0fFRsOTB4OUi0N|Y>
MKN-1 NYmzZ2p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjn[pdKSzVyPUCuOlQh|ryP NUTIdZU3OTB4OUi0N|Y>
PC14 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwOTFOwG0> MmH3NVA3QTh2M{[=
T24 NVHSOVc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;YbpNKSzVyPUCuOlQh|ryP NUDibY4zOTB4OUi0N|Y>
U937 M1Kyd2Z2dmO2aX;uJGF{e2G7 NX7FUoNqOjRiaB?= NVjEUpZ[TE2VTx?= M{jic2lvcGmkaYTzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SC5aYToJGlEPTBib3[gNE4yKM7:TR?= M1fkTVExPzhyOUGx
H460pv8/eto MVHDfZRwfG:6aXOgRZN{[Xl? NWLaO|ZIOTByIN88US=> MnS2OFghcA>? MVfTZYxqdmV? MmPkTWM2OD1yLkCyJO69VQ>? NHL4U|cyODd6MEmxNy=>
H460pv8 M2m1cGN6fG:2b4jpZ{BCe3OjeR?= NXLnV4FVOTByIN88US=> M2\YTVQ5KGh? MXTTZYxqdmV? M33FNmlEPTB;MD6wNFQh|ryP MnvmNVA4QDB7MUO=
MDA-231 M2HF[2N6fG:2b4jpZ{BCe3OjeR?= MoHwNVAxKM7:TR?= MYK0PEBp MWnTZYxqdmV? NU\hdJMyS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBMVI{OSClZXzsJEhGWi1uRVfGVkstdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB4IN88US=> MXSxNFc5ODlzMx?=
MDA-468 MV\DfZRwfG:6aXOgRZN{[Xl? M{jGNlExOCEQvF2= NHrIbZo1QCCq MXfTZYxqdmV? MluxR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUS2PEBk\WyuIDjFVk0tKGGvcHzp[olm\CCHR1\SMEBufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODVizszN NUG1OG9LOTB5OEC5NVM>
NCI-H226 NIrZXVNEgXSxdH;4bYMhSXO|YYm= M{HUZVExOCEQvF2= NX[wWmE2PDhiaB?= Mnq4V4FtcW6n MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBPS0lvSEKyOkBk\WyuIDjteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFgh|ryP MoW0NVA4QDB7MUO=
NCI-H322 NHvnbGNEgXSxdH;4bYMhSXO|YYm= NVi0cmVzOTByIN88US=> MlXUOFghcA>? M2Xpe3NidGmwZR?= NIrrdJFEgXSxdH;4bYNqfHliYXfhbY5{fCCQQ1mtTFMzOiClZXzsJEhufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xOyEQvF2= M{HWNFExPzhyOUGz
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NCI-H647 Mkf4R5l1d3SxeHnjJGF{e2G7 NH3MTJIyODBizszN NHvZXGg1QCCq NImyZpJU[WyrbnW= NETJbYhEgXSxdH;4bYNqfHliYXfhbY5{fCCQQ1mtTFY1PyClZXzsJEhufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODFizszN M4KxWVExPzhyOUGz
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L1210 M1TadmN6fG:2b4jpZ{BCe3OjeR?= NV:zTmdLUUN3ME2wMlAzPSEQvF2= MVmxNFg6ODF4Nx?=
D40 M{Swd2N6fG:2b4jpZ{BCe3OjeR?= NIjpS|MzPCCq MoTmSG1UVw>? M1HocmlEPTB;MT6xO|Ih|ryP M4Lzb|ExQTV4MkG0
OVCAR-3 NHPkcY5EgXSxdH;4bYMhSXO|YYm= NW\6S2xCOjRiaB?= NYjFbVNQTE2VTx?= MXjJR|UxRTBwMEO1JO69VQ>? NX72ZpBlOTB7NU[yNVQ>
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MDA-MB-231 MWLGeY5kfGmxbjDBd5NigQ>? MVS1JO69VQ>? MWGyOEBp MoHERY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBu[Wyxbons[IlidGSnaInk[UBt\X[nbB?= M2\PeVI{QTd|MkGz
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HUVEC MmH4SpVv[3Srb36gRZN{[Xl? NXTJelVqPSEQvF2= NG\kVXAzKGh? MVzD[YxtfWyjcjD1dJRic2V? MV:yOFAzQDR2Nh?=
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AS49-RAW Mmq3R5l1d3SxeHnjJGF{e2G7 NInuZnMyODBizszN MV[0PEBp NYWxVoxOUUN3ME2zNk44QCEQvF2= NH;nNmIzPDB5N{WyPC=>
Caov3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHDO|IhcA>? M1zJdWlEPTB;MD6xJO69VQ>? M{LwclI1ODl3MEi5
LNcaP MY\GeY5kfGmxbjDBd5NigQ>? MkL4N{DPxE1? MUKyOEBp MkXZTY5kemWjc3Wgc4Yh[2ynYY\l[EBk[XOyYYPlMVkhdGW4ZXy= NV:wSZF3OjRyOUWwPFk>
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OVCAR8 NGm5R3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXGyNEDPxE1? NXjH[INnPzJiaB?= MmW3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= M{fIPFI1ODl3MEi5
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MDA-MB-468 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[wNVAh|ryP M3;UZlczKGh? M{LMRWdKPTB;MD6wPFUh|ryP MWeyOFE3Ozd{OR?=
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MKN28 NF64RY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzTcJE1QCCq M1TaPWdKPTB;MD6yOEDPxE1? Mkn6NlQyQDRyN{[=
SGC7901 NXzmVoNES3m2b4TvfIlkKEG|c3H5 MVHJR|UxRTBwMEGxJO69VQ>? NILsR5MzPDF7NUS2Oi=>
Bel7402 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv0SIw6PiCq NV62ZVB1TE2VTx?= MVvJR|UxRTBwNUe4NkDPxE1? MoPBNlQzOTF4M{m=
CHP100 NV;VeI9tS3m2b4TvfIlkKEG|c3H5 M3rzbFczKGh? NIS1eW9KSzVyPUCuO|kh|ryP MoXSNlQzPTF2MUe=
MGC803 Mm\tR5l1d3SxeHnjJGF{e2G7 Mn7DO|IhcA>? NUSxNFl5UUN3ME2wMlE4KM7:TR?= MX6yOFM4ODFzNB?=
ME180 NHvPUm5EgXSxdH;4bYMhSXO|YYm= M4T5clQ5KGh? NUL6ZphYUUN3ME2wMlM6KM7:TR?= NGDDTW8zPDR6N{G4PC=>
L929 MUDDfZRwfG:6aXOgRZN{[Xl? NHTGWYUyNjFyIN88US=> MVW3NkBp Mlj5SG1UVw>? M1P1[WlEPTB;MD6xOkDPxE1? MlrvNlQ2OzByM{C=
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TUR NHq5SHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LpcGlEPTB;N{[uN|Ihdk1? NFm2OFFUSU6JRWK=
TE-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nJTWlEPTB;N{[uN|Uhdk1? MYrTRW5ITVJ?
CMK MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTd5LkSyJI5O Moe2V2FPT0WU
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SW1573 NXzwUmdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHd2lEPTB;OEKuPFEhdk1? NFjabYpUSU6JRWK=
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PANC-10-05 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTh6LkS1JI5O Mo\uV2FPT0WU
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K5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTl4Lkmgcm0> Mn\jV2FPT0WU
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SW1783 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjYVJRKSzVyPUm3Mlk6KG6P MVvTRW5ITVJ?
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MES-SA MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzNWnZKSzVyPUm5MlU{KG6P M33lc3NCVkeHUh?=
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KYSE-410 NHTrUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHjPZN{UUN3ME2xNFMvPDZibl2= NFr5eI5USU6JRWK=
NCI-H1618 NILlUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHXTWM2OD1zMESuN|Uhdk1? Mlv6V2FPT0WU
AU565 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;T[GJbUUN3ME2xNFQvPTFibl2= NEjrWmhUSU6JRWK=
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MMAC-SF MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHuTY1uUUN3ME2xNFYvPDhibl2= MnLXV2FPT0WU
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NCI-H596 M3LJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7ETWM2OD1zMEiuNFEhdk1? NFXpZpRUSU6JRWK=
LXF-289 M1OwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfRTWM2OD1zMEmuNlQhdk1? M1TCOnNCVkeHUh?=
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EHEB NYTZWJdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PldWlEPTB;MUGyMlU6KG6P NHPVfIhUSU6JRWK=
TE-10 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq0TWM2OD1zMUKuOlghdk1? M1vlXnNCVkeHUh?=
MZ7-mel M4DvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHFTnZCUUN3ME2xNVIvQDRibl2= MUXTRW5ITVJ?
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TK10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFzND62JI5O NVLRSYM5W0GQR1XS
SW13 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XaWWlEPTB;MUG1MlI3KG6P MkSzV2FPT0WU
HCC1937 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFzNT64OEBvVQ>? NV;UZ5N5W0GQR1XS
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OVCAR-5 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:2V2lEPTB;MUG2MlgyKG6P M4H4eHNCVkeHUh?=
SW837 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTnTWM2OD1zMUeuPVUhdk1? M3rNS3NCVkeHUh?=
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LB647-SCLC Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH22TnpKSzVyPUGyN{4{PSCwTR?= MlXxV2FPT0WU
NCI-H1703 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPqcJlKSzVyPUGyOk41OiCwTR?= NGnmbmRUSU6JRWK=
KURAMOCHI MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf5S5plUUN3ME2xNlYvPzZibl2= MWPTRW5ITVJ?
ATN-1 NVTBO3JUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jUOmlEPTB;MUK3Mlchdk1? M3XFVXNCVkeHUh?=
SK-CO-1 NYfCcW5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3PTWM2OD1zMkmuNlEhdk1? MWPTRW5ITVJ?
RPMI-7951 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH5b3ZQUUN3ME2xN|AvOTRibl2= MYjTRW5ITVJ?
NCI-H1648 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF|MT65OEBvVQ>? NVKxR3BZW0GQR1XS
NCI-H64 M{X0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL3[FJKSzVyPUGzNk43PSCwTR?= NFi3VlJUSU6JRWK=
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JiyoyeP-2003 NV21bnd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHeyeYVKSzVyPUGzO{45KG6P Mor5V2FPT0WU
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BB65-RCC MlzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH0VZlKSzVyPUG0PU4{OSCwTR?= M{nnfXNCVkeHUh?=
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OVCAR-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v4NGlEPTB;MUW2Mlc5KG6P M3XFTnNCVkeHUh?=
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NCI-H2052 M4XJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF4MD60O{BvVQ>? MlPPV2FPT0WU
DB NInxXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHlZ4V5UUN3ME2xOlEvPzFibl2= NGLSdY1USU6JRWK=
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HCE-T NXvqb3IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTBOmJWUUN3ME2xOlQvQDdibl2= NV;1SIw3W0GQR1XS
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KU-19-19 Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n2VmlEPTB;Mj6yOlkyPyEQvF2= NVnLNXNkW0GQR1XS
A704 M3zoUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXkcnRKSzVyPUKuNlkyOzVizszN MUnTRW5ITVJ?
EVSA-T NVz6RZN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTiTWM2OD1{LkOwNFg6KM7:TR?= Moj4V2FPT0WU
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HuO-3N1 M1X0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\KOVhKSzVyPUKuN|Y2QDNizszN M2S5PHNCVkeHUh?=
GMS-10 NFvSO|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\qTWM2OD1{LkO5O|M5KM7:TR?= NWLOTIF[W0GQR1XS
TGBC24TKB M{nVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\Ed2lEPTB;Mj60NVQzQSEQvF2= Ml3nV2FPT0WU
C2BBe1 NXTjUXhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH32SIFKSzVyPUKuOVE{OjhizszN NHHtUpZUSU6JRWK=
SK-N-DZ NFSxWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi4VIJKSzVyPUKuOVY2QTJizszN NG\hS3JUSU6JRWK=
SK-N-AS MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3rRmVKSzVyPUKuO|MxOTVizszN NITMS5lUSU6JRWK=
T98G MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwOEC0NFEh|ryP Mn3xV2FPT0WU
DMS-79 NHrMRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJwOUC5PFgh|ryP M2rRN3NCVkeHUh?=
SNU-475 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\RbI1YUUN3ME2yMlkzPTd{IN88US=> MXzTRW5ITVJ?
COLO-792 NV;nTpFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfKTWM2OD1|LkCyPFch|ryP NUTqWYh4W0GQR1XS
YAPC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHsZWJvUUN3ME2zMlMzQDN{IN88US=> MU\TRW5ITVJ?
UACC-812 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTNwM{O3N|gh|ryP NV3McYhCW0GQR1XS
Mewo MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPDTWM2OD1|LkS2NFg3KM7:TR?= MlLMV2FPT0WU
COLO-824 NX3NZmNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLJPYJyUUN3ME2zMlU4Ozd6IN88US=> MkDrV2FPT0WU
SCC-9 NUDxUJBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXVTWM2OD1|LkmxN|A6KM7:TR?= NGfWenBUSU6JRWK=
CP50-MEL-B MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnNWJhKSzVyPUOuPVg4ODNizszN MknpV2FPT0WU
NCI-H345 NHvXdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL6W5NKSzVyPUSuNFEyPzRizszN NIPFUYxUSU6JRWK=
COR-L88 NV3rR2YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHjOVVzUUN3ME20MlM6PThizszN NFO1O3RUSU6JRWK=
RCM-1 NUO1TY1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC0W4VKSzVyPUSuOFkzPzJizszN NH3mO2VUSU6JRWK=
JVM-3 M3z3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK0TWM2OD12Lk[wOlE5KM7:TR?= NHTBZ5NUSU6JRWK=
ECC4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLDT4hKSzVyPUSuO|Y2PDFizszN MXnTRW5ITVJ?
MDA-MB-453 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnDUYxFUUN3ME20Mlg2OTN2IN88US=> Mo[1V2FPT0WU
SK-N-FI M3vl[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTVwMkK4O|ch|ryP NHjmU3JUSU6JRWK=
D-502MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7TVnJKSzVyPUWuNlQzPjJizszN MVHTRW5ITVJ?
NCI-H2227 M3PSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\ncpRuUUN3ME21MlM3OjNzIN88US=> NF30cXlUSU6JRWK=
DMS-53 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PBRWlEPTB;Nj6xO|ExPiEQvF2= M2XYR3NCVkeHUh?=
LB771-HNC NYXSbVZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3YdmtKSzVyPU[uOFY5ODZizszN Mmi5V2FPT0WU
BB49-HNC NYq5TZgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTdwNEG3PVEh|ryP NFfpdmZUSU6JRWK=
MDA-MB-415 NFfyfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnqTWM2OD15LkW3N|A{KM7:TR?= MVLTRW5ITVJ?
TALL-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P1dWlEPTB;Nz65Olg5KM7:TR?= NHnzcGVUSU6JRWK=
HCC1395 NISz[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1eZlKSzVyPUiuNVUyOjJizszN M2TKWXNCVkeHUh?=
EFE-184 M3XwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvBTnl6UUN3ME24MlM4OjF4IN88US=> NVvZU|lHW0GQR1XS
EC-GI-10 M1yzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHewO4pKSzVyPUiuOlg3QDZizszN NFi1boZUSU6JRWK=
TT MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPBTWM2OD17LkC2PVY3KM7:TR?= NVzKdXVzW0GQR1XS
U-2-OS Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\6NWVKSzVyPUmuPFE{QTNizszN NF\Wd49USU6JRWK=
SHP-77 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3RpNKSzVyPUmuPVAzQSEQvF2= NHHmUY9USU6JRWK=
HCC1143 NGX3OHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFyLkS3PVch|ryP M{TGOnNCVkeHUh?=
A498 MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF6LkK5O|Yh|ryP M3rQWnNCVkeHUh?=
LS-513 MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS3dG1KSzVyPUG4MlYxQTNizszN MnrHV2FPT0WU
K052 NXHoXXdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M134OWlEPTB;MkGuOFQyQCEQvF2= M2LJWHNCVkeHUh?=
SiHa NV7uZ5l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XpUGlEPTB;MkOuN|M4OSEQvF2= M3fGbHNCVkeHUh?=
RCC10RGB NXfJTHJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqyTWM2OD1|MD6wOlEyKM7:TR?= MVHTRW5ITVJ?
NCI-SNU-16 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNzLkG4N|Yh|ryP M1fYXXNCVkeHUh?=
SNU-C1 M2exd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC5TYVKSzVyPUOyMlQyPzVizszN MlHBV2FPT0WU
C32 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfsZWY6UUN3ME2zNk45PzJizszN MXjTRW5ITVJ?
SW684 NXL1RmlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmizTWM2OD1|ND6xOVYyKM7:TR?= NWTBTHdbW0GQR1XS
SK-MEL-28 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTtT4xPUUN3ME2zOU42Ozd5IN88US=> MkHVV2FPT0WU
SK-MEL-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33rfmlEPTB;M{[uO|U1PyEQvF2= Ml\HV2FPT0WU
NCI-H720 NX7PVoE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zJc2lEPTB;NEGuPVczPiEQvF2= M{Hn[HNCVkeHUh?=
P31-FUJ NH7leXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrBTWM2OD12ND6zNlg1KM7:TR?= MWTTRW5ITVJ?
NCI-H524 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXSXWJRUUN3ME20PE45OjR6IN88US=> MoHjV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
POU5F1 / SOX2 / NANOG; 

PubMed: 27929731     


NT2/D1 cells treated with 10 nM of doxorubicin were subjected to WB analysis for pluripotency factors (POU5F1, NANOG, SOX2) and differentiation markers (TUBB3).

ATG5 / ATG7 / SQSTM1 / LC3A-II / LC3B-II / p-mTOR; 

PubMed: 27929731     


NT2/D1 cells treated with 10 nM of doxorubicin were subjected to WB analysis for autophagy markers (ATG5, ATG7, SQSTM1, LC3A-II, LC3B-II and p-MTOR). 

P62 / LC3II; 

PubMed: 28208617     


(A,B) Doxorubicin induces autophagy in pancreatic cancer cells. Western blot analysis of LC3-II and p62 protein levels in Mia PaCa-2 and Panc-1 cell lines treated with indicated concentrations of doxorubicin for 24 h, or treated with 2.5 μM doxorubicin for indicated times.

p-AKT(T308) / p-Akt(S473) / Akt / p-PRAS40(T246) / PRAS40 / p-H2A.X(S139); 

PubMed: 26027929     


MCF10A cells were serum-starved and treated with (A) 2 μM doxorubicin over a 10 hour time course.

27929731 28208617 26027929
Growth inhibition assay
Cell viability; 

PubMed: 25871400     


Salinomycin enhances the cytotoxicity of doxorubicin in HCC cellsRelative cell viability (mean ± SD) for salinomycin (black), doxorubicin (blue) and doxorubicin plus salinomycin (red) in HuH-7, HepG2, SNU-449 and SNU-387 cells.

25871400
Immunofluorescence
LC3; 

PubMed: 24970805     


Doxorubicin induces GFP-LC3 puncta formation in hepatocellular carcinoma cells. SK-Hep1 cells were treated with doxorubicin (2.5 μM) or CQ (10 μM) plus doxorubicin for 7 h and cells were examined with a confocal microscope for GFP-LC3 punctuation/aggregation.

24970805
ELISA
OPN; 

PubMed: 24963635     


A549 were exposed to 50 nM doxorubicin or PBS for 48 h. OPN concentrations in cell culture media were determined by ELISA.

24963635
In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Female athymic nude mice injected s.c. with MB231 cells
  • Formulation: Dissolved in DMSO, and diluted in saline
  • Dosages: 3 mg/kg/day
  • Administration: Delivered intratumorly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage powder
in solvent
Synonyms NSC 123127

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04032964 Not yet recruiting Drug: L19TNF|Drug: DOXORUBICIN Soft Tissue Sarcoma Philogen S.p.A. September 2019 Phase 1
NCT03975205 Not yet recruiting Drug: Doxorubicin Lymphoma Leukemia Sutphin Drugs|Bharath Charitable Cancer Hospital and Institute July 1 2019 Early Phase 1
NCT03591276 Recruiting Drug: Chemotherapy Drugs Cancer Metastatic Breast Cancer Shaare Zedek Medical Center April 18 2019 Phase 1|Phase 2
NCT03719430 Recruiting Drug: Doxorubicin|Drug: APX005M Soft Tissue Sarcoma Columbia University|Apexigen Inc. March 20 2019 Phase 2
NCT03059615 Recruiting Drug: Nerofe|Drug: Doxorubicin Acute Myelogenous Leukemia|Myelodysplastic Syndromes Immune System Key Ltd October 25 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Why the IC50 of the compound varied over time in our measurement?

  • Answer:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID