PD184352 (CI-1040)

Catalog No.S1020

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

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In DMSO USD 140 In stock
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Cited by 62 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HmfWlEPTB;MD6wNlI4PiEQvF2= MorvV2FPT0WU
CHP-212 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;oNWlEPTB;MD6wNlg5PSEQvF2= MonvV2FPT0WU
EoL-1-cell NUjI[XdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknjTWM2OD1yLkC0NVUzKM7:TR?= M2DqPHNCVkeHUh?=
DU-4475 NH\adGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEe1PVkh|ryP NWrKVHpTW0GQR1XS
MMAC-SF NXjq[Zk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojITWM2OD1yLkGwPVc1KM7:TR?= NVrCbIUyW0GQR1XS
AGS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fRbmlEPTB;MD6xNVcyOyEQvF2= MmT5V2FPT0WU
M14 M{H3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom3TWM2OD1yLkG1OFY5KM7:TR?= NGPKfmdUSU6JRWK=
CP50-MEL-B M3nrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjlUllbUUN3ME2wMlE4OjV2IN88US=> NFPQR3pUSU6JRWK=
C32 NXm3WHFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoflTWM2OD1yLkG5NFczKM7:TR?= MXzTRW5ITVJ?
KMOE-2 NGrWeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnRb2pKSzVyPUCuNVk4QTVizszN M{nOXHNCVkeHUh?=
A101D NFroSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLYTGVlUUN3ME2wMlIyPCEQvF2= NGryN2VUSU6JRWK=
KM12 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXsTWM2OD1yLkK0NFU4KM7:TR?= NYO1SHpVW0GQR1XS
HSC-4 NUG4SnNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrn[GJKSzVyPUCuNlQ{QTVizszN M{G5XHNCVkeHUh?=
NOMO-1 M2\ocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMkW3OFIh|ryP M2jOZnNCVkeHUh?=
MZ7-mel MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMk[zOEDPxE1? MUnTRW5ITVJ?
ACN NFjQOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DUeWlEPTB;MD6yOlc{PyEQvF2= MWDTRW5ITVJ?
MEL-HO NFu4T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkexTWM2OD1yLkK3OlUzKM7:TR?= NHzWZoxUSU6JRWK=
BHT-101 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMki2NFYh|ryP NY[ye4hZW0GQR1XS
SK-MEL-28 NEPBd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmftTWM2OD1yLkOwOFA6KM7:TR?= MVrTRW5ITVJ?
KG-1 M2rZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S5WGlEPTB;MD6zNFY3QCEQvF2= M4DodHNCVkeHUh?=
COLO-679 Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm4e|VKSzVyPUCuN|I4OiEQvF2= NVThXHhNW0GQR1XS
SK-MEL-24 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwM{K4NVMh|ryP MYDTRW5ITVJ?
G-361 NV7DblRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLmTWM2OD1yLkO2O|k2KM7:TR?= NHXocnNUSU6JRWK=
KY821 M2LMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHTS4tKSzVyPUCuN|c6OSEQvF2= M1;kNXNCVkeHUh?=
KASUMI-1 NHXiWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\XTWM2OD1yLkO5PUDPxE1? NYTaWXdEW0GQR1XS
HL-60 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L4WWlEPTB;MD60NVExPyEQvF2= NF2wfVFUSU6JRWK=
K5 M3zq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\STWM2OD1yLkSzNVE4KM7:TR?= NWLh[3ptW0GQR1XS
KU812 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PvR2lEPTB;MD60OVI6QSEQvF2= NXHUN3Y6W0GQR1XS
SH-4 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwNE[yOVYh|ryP MX;TRW5ITVJ?
HTC-C3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwNE[1N|Eh|ryP MWLTRW5ITVJ?
CP66-MEL M{\PR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnqT5RMUUN3ME2wMlQ5QDB7IN88US=> NHrsTWZUSU6JRWK=
WM-115 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzvXVJKSzVyPUCuOFkzPTdizszN NF\VbmZUSU6JRWK=
A2780 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrpfGtQUUN3ME2wMlQ6QDJ|IN88US=> NVvCbpdUW0GQR1XS
P12-ICHIKAWA NEH1Ro9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwNkGyNlEh|ryP MmXEV2FPT0WU
HMV-II NG\JS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqybHdKSzVyPUCuOlQ1PjVizszN NYe4bVdEW0GQR1XS
HT-144 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jCemlEPTB;MD62OFY2PyEQvF2= M3nJOXNCVkeHUh?=
LB2518-MEL NX3X[YJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jZe2lEPTB;MD63NVY{OiEQvF2= MUfTRW5ITVJ?
NCI-SNU-1 NIS4SFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwN{W0N|Mh|ryP MnLEV2FPT0WU
C2BBe1 NXHCU|JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorGTWM2OD1yLkixNFI{KM7:TR?= NHf5cFlUSU6JRWK=
PSN1 NISydY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXD[ldKSzVyPUCuPVYyQTZizszN M3fiXHNCVkeHUh?=
UACC-257 M1\DW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LCbGlEPTB;MD65OlQ4OyEQvF2= NYnMfoRsW0GQR1XS
RVH-421 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;HeoFWUUN3ME2wMlk4OThizszN MkPsV2FPT0WU
GP5d MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTQfJZlUUN3ME2wMlk5OzB6IN88US=> NX70e3hmW0GQR1XS
TYK-nu M1TtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtRVN3UUN3ME2xMlA{OTd{IN88US=> NXvjeIlKW0GQR1XS
SK-N-AS NWrldHBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXFfndKSzVyPUGuNFc6PDdizszN M4GwbXNCVkeHUh?=
SW620 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXWUJBKSzVyPUGuNVM2OzRizszN MWrTRW5ITVJ?
HuP-T4 NFi3TYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PHUGlEPTB;MT6xPFM2QSEQvF2= MVnTRW5ITVJ?
A549 NF;5[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fnVWlEPTB;MT6xPVU4PiEQvF2= NVnP[W57W0GQR1XS
Mewo NEnZcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml71TWM2OD1zLkKwNlc3KM7:TR?= M4rUNnNCVkeHUh?=
ONS-76 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwMkKwOFkh|ryP MXTTRW5ITVJ?
SK-MEL-1 M4LHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMkO0NVkh|ryP NWe5OFluW0GQR1XS
RCM-1 NVixblduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rkR2lEPTB;MT6yOFA1PyEQvF2= MWfTRW5ITVJ?
H-EMC-SS NIHLcIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fKVmlEPTB;MT6yPVYxQCEQvF2= M3PwSnNCVkeHUh?=
NCI-H2291 Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDJRo1PUUN3ME2xMlMzPTN4IN88US=> MUnTRW5ITVJ?
SW1463 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fPdmlEPTB;MT6zN|czOSEQvF2= MnjMV2FPT0WU
LS-411N MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPJTWM2OD1zLkSwOVE4KM7:TR?= M3XjPHNCVkeHUh?=
BV-173 M4nQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwNESwNVUh|ryP MV\TRW5ITVJ?
LS-513 NXvyWlVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwNEWxPVIh|ryP MWrTRW5ITVJ?
LoVo M17PPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwNE[zPVkh|ryP NGXWcI1USU6JRWK=
HO-1-N-1 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLNPIdKSzVyPUGuOVE3OzRizszN MmHWV2FPT0WU
ML-2 M1ixfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoWxTWM2OD1zLkWyPFY5KM7:TR?= NF2wOlNUSU6JRWK=
NCI-H1437 M1rYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O1N2lEPTB;MT61OVI4PSEQvF2= MkGzV2FPT0WU
SW1116 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLTVo1rUUN3ME2xMlU3Ozl6IN88US=> M1T3RXNCVkeHUh?=
A4-Fuk M36wOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwNUewOFUh|ryP NVTWc5Z4W0GQR1XS
HD-MY-Z MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXOTWM2OD1zLkW3N|c3KM7:TR?= MXjTRW5ITVJ?
SK-MEL-2 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDRWVZKSzVyPUGuOVc1PTlizszN NVf3TZFpW0GQR1XS
RT-112 NXLsTWxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnQOmRDUUN3ME2xMlU5QTV{IN88US=> MVPTRW5ITVJ?
COLO-829 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XER2lEPTB;MT62NlI{OiEQvF2= MkPoV2FPT0WU
OVCAR-5 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP3TWM2OD1zLke3Olg4KM7:TR?= NIHPTmxUSU6JRWK=
NB69 NHTxbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwN{i0Olkh|ryP NW\MR|VxW0GQR1XS
NCI-H292 MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vIeWlEPTB;MT64OlY6QSEQvF2= MYHTRW5ITVJ?
LOXIMVI NGrMPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm0e|hKSzVyPUGuPFk1OjdizszN MVPTRW5ITVJ?
BPH-1 M3jTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\sU2lEPTB;MT64PVU6OSEQvF2= MYnTRW5ITVJ?
A375 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImzdo5KSzVyPUGuPFk4OTRizszN M{TLUHNCVkeHUh?=
LCLC-97TM1 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;6foNKSzVyPUGuPVIzPTZizszN MXnTRW5ITVJ?
RXF393 M{TRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnhd4tDUUN3ME2xMlk4QDh5IN88US=> Ml6zV2FPT0WU
HCC70 NUnFNnJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\tfmhKSzVyPUKuNFI1OjZizszN NYewRXlyW0GQR1XS
EM-2 NHjKb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTRTWM2OD1{LkC3NVk5KM7:TR?= NXXUXFJXW0GQR1XS
MZ2-MEL NWHKPGhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJwMUGxNlch|ryP MmrCV2FPT0WU
HN MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHjTWM2OD1{LkG2Nlc5KM7:TR?= MliwV2FPT0WU
A2058 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJwMUmyO|kh|ryP M2TwRnNCVkeHUh?=
NB7 M33SXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmwTWpKSzVyPUKuN|QxQDZizszN NX\4WY9YW0GQR1XS
DOK MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PofmlEPTB;Mj6zOVc4OyEQvF2= MknvV2FPT0WU
CAL-27 NWTvRlVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwM{myN|Yh|ryP MVfTRW5ITVJ?
BB65-RCC MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWfHVCUUN3ME2yMlQxPjd2IN88US=> MojiV2FPT0WU
RD NEnoXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwNES3NlMh|ryP M13WNHNCVkeHUh?=
KNS-62 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\LcllKSzVyPUKuOVEyPjRizszN MmLFV2FPT0WU
EW-13 MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DUR2lEPTB;Mj61OlM{QSEQvF2= NVnhUlNDW0GQR1XS
DB M4\rbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJwNUi3PFgh|ryP M4Tj[3NCVkeHUh?=
HCC2218 NE[xcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHQTWM2OD1{Lk[0O|c5KM7:TR?= MXPTRW5ITVJ?
L-363 NXGwV3V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXfGlEPTB;Mj63OFM4KM7:TR?= MY\TRW5ITVJ?
CHL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvFTWM2OD1{LkiwO|g2KM7:TR?= MWjTRW5ITVJ?
BFTC-905 NIPqOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXm2W4pnUUN3ME2yMlgzPTNizszN NGK4dVJUSU6JRWK=
HCE-T NH7qVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\JTWM2OD1{LkizNlY1KM7:TR?= NUPFOmVMW0GQR1XS
COLO-792 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nsV2lEPTB;Mj64OFAzPyEQvF2= NIXsWJhUSU6JRWK=
LB2241-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG2VmFKSzVyPUKuPFU5QTNizszN MoDDV2FPT0WU
CAL-39 NYLMV|BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrlTWJKSzVyPUKuPFk6QTlizszN M4DO[HNCVkeHUh?=
T-24 NXTDXml3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwOUGxNVIh|ryP NVfyVmhxW0GQR1XS
NCI-H727 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDMTWM2OD1{LkmxO|k3KM7:TR?= MnzMV2FPT0WU
Ca9-22 M1HKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\acJpKSzVyPUKuPVczPTVizszN NYXNSmhuW0GQR1XS
MIA-PaCa-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK2TWM2OD1|LkCwO|gyKM7:TR?= NUHobHhPW0GQR1XS
HT-1080 NYfwVoZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTNwMEG5PVch|ryP M3HYdHNCVkeHUh?=
D-423MG NWnGfXpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNwMEe3OVMh|ryP MoOxV2FPT0WU
LAMA-84 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrGcWxKSzVyPUOuNVM2QCEQvF2= M2DISXNCVkeHUh?=
SW780 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:2NpVKSzVyPUOuNVQzOjlizszN NHjseGVUSU6JRWK=
KU-19-19 NUPjd4duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGySI1KSzVyPUOuNVcxOzRizszN NXTidVF5W0GQR1XS
COLO-741 NUjaWYNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTNwMUi2O|Mh|ryP MY\TRW5ITVJ?
HSC-3 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X3RmlEPTB;Mz6yN|E2OSEQvF2= NWDnfGxVW0GQR1XS
SN12C NXzSeGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLCTWM2OD1|LkK0O|AyKM7:TR?= MY\TRW5ITVJ?
786-0 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3RVIJKSzVyPUOuNlczPDNizszN MnriV2FPT0WU
GAK MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTNwM{K1OlEh|ryP MWPTRW5ITVJ?
PANC-03-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Sz[GlEPTB;Mz6zOVA1PSEQvF2= MWTTRW5ITVJ?
CTB-1 M1XvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNwNEewOFch|ryP NIPTd5BUSU6JRWK=
A427 NEnPPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jxRWlEPTB;Mz61PVU2PiEQvF2= MojCV2FPT0WU
EGI-1 M3WyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfCW4hsUUN3ME2zMlYxPTh|IN88US=> NGPjbHFUSU6JRWK=
U-2-OS Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LUbmlEPTB;Mz62O|I2PiEQvF2= MW\TRW5ITVJ?
NCI-SNU-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyXGlEPTB;Mz62O|c{KM7:TR?= NV7KVG15W0GQR1XS
SK-LU-1 MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW2SYtwUUN3ME2zMlY5Pzl6IN88US=> MYnTRW5ITVJ?
697 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq3TWM2OD1|Lk[5OlA{KM7:TR?= M3n6WnNCVkeHUh?=
HPAF-II NWHrN5FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rtZ2lEPTB;Mz63OVQ6KM7:TR?= M3P5U3NCVkeHUh?=
NCI-H2087 M4jLTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTNwOES2O|Ih|ryP MY\TRW5ITVJ?
SK-MEL-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnUfI1KSzVyPUOuPFUyPTRizszN NULQSXZOW0GQR1XS
CGTH-W-1 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTNwOEW3NlUh|ryP MX3TRW5ITVJ?
8505C M2rTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\sOmlEPTB;Mz65NFA4QCEQvF2= NVXSZlV[W0GQR1XS
GAMG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfJUlNyUUN3ME20MlAzOzd5IN88US=> NISy[XZUSU6JRWK=
SW626 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD2bGRLUUN3ME20MlA1PDhizszN M2HLXHNCVkeHUh?=
CAL-62 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\4NmlEPTB;ND6wO|Q{KM7:TR?= NHTlSolUSU6JRWK=
MHH-PREB-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPHTWM2OD12LkGyNVEyKM7:TR?= MY\TRW5ITVJ?
RPMI-7951 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXJNJdKSzVyPUSuNlU2QDlizszN NH;UR2ZUSU6JRWK=
HOP-92 M37lWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTaZ5hKSzVyPUSuNlU3PyEQvF2= M4TLSnNCVkeHUh?=
MDA-MB-231 NUPRV4ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTRwMkmyNlMh|ryP Mn7XV2FPT0WU
LAN-6 NHP5WGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XZ[GlEPTB;ND6zNVY{PyEQvF2= MmX4V2FPT0WU
ALL-PO M4LFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHoU2NKSzVyPUSuN|YyPTZizszN MY\TRW5ITVJ?
HH M1LMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DWPGlEPTB;ND60NVU6PyEQvF2= NGLFZ2NUSU6JRWK=
IGROV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP6fpNKSzVyPUSuOFUyPzFizszN NH3lWoFUSU6JRWK=
NCI-H358 M3zQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G0d2lEPTB;ND60OVM5PSEQvF2= M1znXXNCVkeHUh?=
NB5 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLYTWM2OD12Lk[wN|Y6KM7:TR?= M1fFW3NCVkeHUh?=
NCI-H747 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFftRpNKSzVyPUSuOlg5ODdizszN NV\H[HZOW0GQR1XS
NH-12 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TVb2lEPTB;ND63NVYzPSEQvF2= M{nqT3NCVkeHUh?=
LB1047-RCC M3fPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDXWpNKSzVyPUSuO|M5OTVizszN M4W5R3NCVkeHUh?=
EFO-27 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD12Lke4OlY4KM7:TR?= NY\zdHU3W0GQR1XS
EPLC-272H MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rLPWlEPTB;ND65PVY3QSEQvF2= MoS0V2FPT0WU
CAL-54 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTIWmxKSzVyPUWuNFI3QTVizszN MUTTRW5ITVJ?
H4 M1Hwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH5TWM2OD13LkC0NlU2KM7:TR?= MlO0V2FPT0WU
MOLT-13 M1HaeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PQb2lEPTB;NT6wOlc4PiEQvF2= MkfsV2FPT0WU
CAL-33 MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjvTWM2OD13LkGyN|E4KM7:TR?= M1LkXXNCVkeHUh?=
23132-87 M{DyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjWdHQ2UUN3ME21MlE3QDd{IN88US=> MWPTRW5ITVJ?
UM-UC-3 NGKwenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTVwMUiwOFch|ryP MlWzV2FPT0WU
HuH-7 NGrlN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\OTGJKSzVyPUWuNlcyPDdizszN MlnOV2FPT0WU
BCPAP M4n1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37rb2lEPTB;NT6zNlk3QSEQvF2= NYHaS416W0GQR1XS
AsPC-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojmTWM2OD13LkO2O|Y{KM7:TR?= NU[5[WZyW0GQR1XS
NCI-H1155 NWC1Rmx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOzbYRKSzVyPUWuOFAxPTFizszN M{WxN3NCVkeHUh?=
GT3TKB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrEVmhKSzVyPUWuOFY2QThizszN NHrSTHdUSU6JRWK=
HCC2998 MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS4VpUyUUN3ME21MlQ6OTB7IN88US=> MmnLV2FPT0WU
NUGC-3 NGL3U5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFruSW9KSzVyPUWuOFk{ODJizszN NVX5U5plW0GQR1XS
Hs-578-T NHrFbWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHyNIhKSzVyPUWuOVM4QTRizszN NV63b21KW0GQR1XS
FADU NHPzb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL1TWM2OD13LkW1O|I3KM7:TR?= NGfXeFZUSU6JRWK=
NBsusSR MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnBbllKSzVyPUWuOVcyPTVizszN NFfoU5lUSU6JRWK=
ME-180 NUTrfnlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\6R3BKSzVyPUWuOVgxQTJizszN MofVV2FPT0WU
SW1710 M4XF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTVwNkG2OVQh|ryP MlntV2FPT0WU
HuP-T3 M2LQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTVwNkKwNlkh|ryP NGHQVpdUSU6JRWK=
HOS MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P2XWlEPTB;NT62NlkzOyEQvF2= NF;YU3FUSU6JRWK=
PA-1 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DLW2lEPTB;NT62OFI3PSEQvF2= M{n6NHNCVkeHUh?=
LU-99A NG\D[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTVwNk[0OVEh|ryP NX21SIRJW0GQR1XS
RS4-11 M3nxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonzTWM2OD13Lk[2O|c2KM7:TR?= NHTBbGFUSU6JRWK=
TE-8 NYLHVmdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe4WJdxUUN3ME21MlY5PTN5IN88US=> NHTwVldUSU6JRWK=
RERF-LC-MS MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKxdmxsUUN3ME21MlY5QDB|IN88US=> NYPZeZJmW0GQR1XS
MEL-JUSO Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HST2lEPTB;NT63N|c5KM7:TR?= M37WNHNCVkeHUh?=
SK-MES-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn0[3JKSzVyPUWuPFM2OjhizszN NGLGfpFUSU6JRWK=
D-263MG NIHKSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTVwOEizOVEh|ryP NET3foNUSU6JRWK=
NB10 M1:yZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXVOmhKSzVyPUWuPFk1PiEQvF2= MYjTRW5ITVJ?
SK-HEP-1 NWHJXo5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;6TWM2OD13LkmzOFcyKM7:TR?= NGSzZVZUSU6JRWK=
HT-29 NVPie|R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTVwOUixNVgh|ryP MVXTRW5ITVJ?
KYSE-140 NHXzW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLOTWM2OD14LkCyNVgzKM7:TR?= NVm3eoJXW0GQR1XS
NCI-H1666 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e5fWlEPTB;Nj6wPFQ3OSEQvF2= Mn3yV2FPT0WU
NCI-H1304 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XmbGlEPTB;Nj6xPVk1KM7:TR?= NFe3PXZUSU6JRWK=
RPMI-8866 MnXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD14LkKxN|E{KM7:TR?= MXTTRW5ITVJ?
MV-4-11 Mn3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vhcWlEPTB;Nj6yN|E6QSEQvF2= MV3TRW5ITVJ?
A431 M2mzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe3bFNrUUN3ME22MlI1Ojl4IN88US=> NUjCdJNIW0GQR1XS
PANC-10-05 NIHoNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjNTWM2OD14LkK4N|Y{KM7:TR?= NETkbnVUSU6JRWK=
TK10 M1;5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTZwM{K2NFQh|ryP NXjNWIU5W0GQR1XS
NCI-H1975 M{e3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfYUFRTUUN3ME22MlQ4OjF3IN88US=> NVfHfIczW0GQR1XS
A172 M3PXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2riZWlEPTB;Nj60PVE4PiEQvF2= NXXKbW1yW0GQR1XS
D-566MG NH\0TVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fLdGlEPTB;Nj61OFMxOyEQvF2= NVS4e|hvW0GQR1XS
NCI-H2122 NYHLTYE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFeybllKSzVyPU[uOlE2OjhizszN NXjrZ5dnW0GQR1XS
COR-L105 M{DMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvZTWM2OD14Lk[1Nlc2KM7:TR?= NUHCSJR3W0GQR1XS
AN3-CA M3HsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTlOZdEUUN3ME22MlY5PjRzIN88US=> NGTteGhUSU6JRWK=
Calu-6 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzKOmdNUUN3ME22Mlc6Pjl6IN88US=> NIrxRmpUSU6JRWK=
HCT-116 NF\mS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHqZlFKSzVyPU[uPFEzPjRizszN MoPVV2FPT0WU
MHH-NB-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTZwOEWwNFIh|ryP M1i1XXNCVkeHUh?=
MFE-280 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj0WoFKSzVyPU[uPFU6QDNizszN MWPTRW5ITVJ?
SW1088 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q2TGlEPTB;Nj65NVkyOyEQvF2= MmXlV2FPT0WU
SW48 M3rjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DMSWlEPTB;Nj65OFUyKM7:TR?= M{\hcXNCVkeHUh?=
HuCCT1 NVjUVoIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37leGlEPTB;Nz6wNVA{PyEQvF2= NUi2UXY1W0GQR1XS
ACHN M17kWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlexTWM2OD15LkCyPVQ{KM7:TR?= NV7nWG9VW0GQR1XS
8305C M{LOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTweIFKSzVyPUeuNFk6QTVizszN M124OnNCVkeHUh?=
DoTc2-4510 NUOzOVFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjMXJZoUUN3ME23MlEzOTVizszN NFr2eGNUSU6JRWK=
COR-L23 M1;udmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzkTWM2OD15LkK0OFIh|ryP MX\TRW5ITVJ?
SK-MEL-30 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjGT5VlUUN3ME23MlI2ODh|IN88US=> NVTvZmRFW0GQR1XS
BE-13 M1XhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HFXWlEPTB;Nz6zN|g{PCEQvF2= NIPVW4JUSU6JRWK=
GR-ST M4fVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjKdGdKSzVyPUeuOFAyPzRizszN NVHUfHRWW0GQR1XS
LU-135 NEjXdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwNUW5N|kh|ryP MnOyV2FPT0WU
U-266 M{PYOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnUTWM2OD15LkW2Nlg3KM7:TR?= MYrTRW5ITVJ?
NCI-H1355 M1XKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzxTWM2OD15LkW4OlM2KM7:TR?= M4PBOnNCVkeHUh?=
NB14 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPwXXhKSzVyPUeuOlY3PDJizszN M3nL[HNCVkeHUh?=
SCC-25 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTdwN{C5JO69VQ>? MlvjV2FPT0WU
COLO-678 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIflVFBKSzVyPUeuO|ExPzZizszN MVXTRW5ITVJ?
TGBC1TKB NEXhclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LDSmlEPTB;Nz64PVM6QCEQvF2= MoK1V2FPT0WU
IST-MEL1 NGjU[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTGTWM2OD16LkCwOFA3KM7:TR?= Mn;uV2FPT0WU
ECC10 NV\5NG9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnYdWRwUUN3ME24MlA{Ozl3IN88US=> MkXxV2FPT0WU
EW-16 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqNYhbUUN3ME24MlA5PDR3IN88US=> MV7TRW5ITVJ?
DOHH-2 NFnBUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLDS|BKSzVyPUiuNlAxQTVizszN MlTQV2FPT0WU
NCI-H1581 NEfCbGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRThwMk[zNlMh|ryP MoDKV2FPT0WU
TE-5 NVqxPVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[yU2JKSzVyPUiuOFI1OjlizszN Mm\kV2FPT0WU
CAKI-1 NHrP[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnwT|VxUUN3ME24MlU4OjJ{IN88US=> NHv2N4pUSU6JRWK=
A673 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRThwNkOyNFIh|ryP NEH6SXNUSU6JRWK=
CAL-12T NWHWOGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7LTWM2OD16Lk[1O|U{KM7:TR?= NV;j[IFRW0GQR1XS
DBTRG-05MG NIP0SnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRThwN{S4OVkh|ryP NVzLXVRrW0GQR1XS
SK-N-FI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr5[2RKSzVyPUiuPFE{PzlizszN M{\tZXNCVkeHUh?=
K-562 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;tcXJoUUN3ME24Mlg{QTV5IN88US=> M37tWXNCVkeHUh?=
SBC-1 M4H0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRThwOE[2OFUh|ryP M3j0XnNCVkeHUh?=
ES4 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRThwOE[4PFQh|ryP Mne2V2FPT0WU
MS-1 NYLKV3R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvnTWM2OD16Lki3OVE4KM7:TR?= MnzmV2FPT0WU
RKO NUniboFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX4TIduUUN3ME24Mlg6ODV5IN88US=> M4TXZnNCVkeHUh?=
NCI-H1693 NX7HV5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi3OFRKSzVyPUiuPVIyPyEQvF2= MVPTRW5ITVJ?
SW954 NHjoNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRThwOU[5O|gh|ryP NITGOmVUSU6JRWK=
SK-UT-1 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRThwOUe2PFMh|ryP M{LESXNCVkeHUh?=
T98G Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn31TWM2OD16Lkm5PFQ3KM7:TR?= NVLZfnJVW0GQR1XS
NCI-H2126 NIjnTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVraOlFCUUN3ME25MlAxQDJ4IN88US=> MmXxV2FPT0WU
TE-12 NF3QblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTlwMEOzOlch|ryP M37PW3NCVkeHUh?=
DK-MG NXfVRVhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTlwMkGxPVEh|ryP M{G5SXNCVkeHUh?=
MEG-01 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTlwMkS5N|Eh|ryP MXnTRW5ITVJ?
HCC1937 M3Xxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzTZWd[UUN3ME25MlI6ODlzIN88US=> NX3Peld4W0GQR1XS
MKN45 NYTVXYtVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu2TWM2OD17LkS1NFY2KM7:TR?= MkHVV2FPT0WU
NCI-H1792 NEfSO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTlwNEWyNVkh|ryP MnnqV2FPT0WU
SW1417 NIWwdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDMe2dnUUN3ME25MlU3QDN5IN88US=> Mkm1V2FPT0WU
639-V NH3LPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1yyPWlEPTB;OT62OFM5QCEQvF2= MXLTRW5ITVJ?
P30-OHK MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT2PGUyUUN3ME25MlY2OzF4IN88US=> MUfTRW5ITVJ?
YKG-1 M4joTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjTTWM2OD17Lke1NFM{KM7:TR?= MVvTRW5ITVJ?
KGN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XjbGlEPTB;OT64N|c6PSEQvF2= NXi2dZF[W0GQR1XS
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NCI-H1573 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFyLkG1O|Qh|ryP NHX0dW5USU6JRWK=
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SK-NEP-1 Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHXTWM2OD1zMD60PVgyKM7:TR?= M3z5Z3NCVkeHUh?=
MKN28 M3;RS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFyLkWxPEDPxE1? Mof5V2FPT0WU
KYSE-520 M3m4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL2TWM2OD1zMD61NkDPxE1? NV[1PZBtW0GQR1XS
KE-37 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjX[G04UUN3ME2xNE42Ojd{IN88US=> NXn4RoxQW0GQR1XS
VA-ES-BJ MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH1U4hzUUN3ME2xNE42PjdizszN MnHXV2FPT0WU
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GMS-10 NITUUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf1fYZKSzVyPUGwMlYxQTRizszN NHn3ZVlUSU6JRWK=
NCI-H1623 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVz4bGJCUUN3ME2xNE43Ozd7IN88US=> M1jCR3NCVkeHUh?=
NEC8 NHz0[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33wcmlEPTB;MUCuO|c4OyEQvF2= NE\GcYNUSU6JRWK=
MOLT-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHiTWM2OD1zMD64NVE{KM7:TR?= MWTTRW5ITVJ?
DJM-1 NYLSXZdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFzLkCzO|kh|ryP Mkf4V2FPT0WU
U251 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTFzLkC0NkDPxE1? MkXSV2FPT0WU
SBC-5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;rTWM2OD1zMT6xOFY4KM7:TR?= M3nybXNCVkeHUh?=
SW756 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfuTWM2OD1zMT6yNVU1KM7:TR?= NF7yV4hUSU6JRWK=
KS-1 NIrzWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XNXWlEPTB;MUGuNlYyQSEQvF2= NInEOlhUSU6JRWK=
SF295 NGHrRmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFzLkOxNFQh|ryP MVrTRW5ITVJ?
YH-13 M2W5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFzLkOyOlch|ryP NH;hRo9USU6JRWK=
SW837 NUPyU3pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrjTWM2OD1zMT6zOVA3KM7:TR?= NHGw[2FUSU6JRWK=
KYSE-450 NIfsRnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LnVWlEPTB;MUGuOFA2PyEQvF2= NX21NWlNW0GQR1XS
KYSE-180 M4\IWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVNZBKSzVyPUGxMlQ5OiEQvF2= MXnTRW5ITVJ?
S-117 NGDhXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv0TWM2OD1zMT60PFk3KM7:TR?= NGL1b3FUSU6JRWK=
KOSC-2 NXnuXYdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7sS4VKSzVyPUGxMlYzOjJizszN M{\kO3NCVkeHUh?=
KYSE-270 NVLiUY5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rxPWlEPTB;MUGuPFc1PSEQvF2= NFntT5FUSU6JRWK=
D-336MG MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjBUG42UUN3ME2xNU46ODd3IN88US=> MoTWV2FPT0WU
KALS-1 NH76OJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M161emlEPTB;MUKuNFAyPiEQvF2= NYfSPZZVW0GQR1XS
LB373-MEL-D NWLLOnFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj5TWM2OD1zMj6wOVM{KM7:TR?= MWXTRW5ITVJ?
HLE NVHkZndIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF{LkC1PFUh|ryP MonPV2FPT0WU
SJSA-1 NWPSO2M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfWbnBpUUN3ME2xNk4xPzN3IN88US=> NV:4cmxyW0GQR1XS
SW1990 NYXHT29JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T2VmlEPTB;MUKuNFkyOSEQvF2= NF;4VZpUSU6JRWK=
NOS-1 M3nQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nwNGlEPTB;MUKuNVM2OiEQvF2= MmTvV2FPT0WU
GI-ME-N MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF{LkKxOlMh|ryP NWLzOHliW0GQR1XS
NCI-H1703 NVPG[ZIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj6bWxKSzVyPUGyMlI3OTZizszN Mn3zV2FPT0WU
ES7 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF{LkK3NlQh|ryP NXizN21ZW0GQR1XS
KYSE-510 M1TBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rGUmlEPTB;MUKuOVA4QSEQvF2= NFvydVFUSU6JRWK=
BHY NH\mfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXK5[IZHUUN3ME2xNk42OzB5IN88US=> NUXL[I14W0GQR1XS
TCCSUP NYfBOIR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzSeIcxUUN3ME2xNk42PzV5IN88US=> NXHrfWcxW0GQR1XS
HSC-2 NWnSNlN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF{LkW5PVYh|ryP NWPET|ZRW0GQR1XS
BEN M4jscGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnYU3N1UUN3ME2xNk43OTR|IN88US=> MnvrV2FPT0WU
769-P MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTMT2NtUUN3ME2xNk44QTJ2IN88US=> NGnQd2RUSU6JRWK=
HT MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;heYtKSzVyPUGyMlg{PDZizszN Ml\oV2FPT0WU
LXF-289 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3USVJKSzVyPUGyMlk2OzFizszN MXjTRW5ITVJ?
OVCAR-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzYSGRKSzVyPUGyMlk2PjdizszN MWDTRW5ITVJ?
ATN-1 NYS5cXU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFcZlKSzVyPUGzMlAyQDRizszN NHPSNIZUSU6JRWK=
8-MG-BA Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPXO2JlUUN3ME2xN{4xPDV3IN88US=> Ml3OV2FPT0WU
SW13 NEG1U5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjWTWM2OD1zMz6xNVY2KM7:TR?= NUjO[Jl[W0GQR1XS
NCI-H1092 NWjafJJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTF|LkG2NkDPxE1? MnjDV2FPT0WU
OAW-42 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq3TWM2OD1zMz6xPVM4KM7:TR?= MUXTRW5ITVJ?
NCI-H2452 NFvsdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SzfWlEPTB;MUOuNlE4PSEQvF2= NWXhPZNsW0GQR1XS
CAPAN-1 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF|LkW1NVQh|ryP M2HMdXNCVkeHUh?=
NCI-H2009 NEPRcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF|LkW5NVkh|ryP NYjuSVJEW0GQR1XS
SF268 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfKTWM2OD1zMz62N|I3KM7:TR?= NFOxbVRUSU6JRWK=
GCIY NXXEWIZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGiwc2dKSzVyPUGzMlY6OjdizszN NYXqVWJtW0GQR1XS
OS-RC-2 NWXYRW0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTBTWM2OD1zMz65OVAyKM7:TR?= MYHTRW5ITVJ?
GCT M1j3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF|Lkm2PVch|ryP NVXacWtuW0GQR1XS
NB17 NUDhUllFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDX[nZKSzVyPUG0MlA5PSEQvF2= Mnm2V2FPT0WU
NCI-H2030 M3LySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF2LkG0OlUh|ryP NVfOU4dMW0GQR1XS
HC-1 NIHpc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF2LkKwPFch|ryP M{jEXnNCVkeHUh?=
QIMR-WIL NWDFPYhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTIdIhKSzVyPUG0MlM1OTJizszN M2jJTnNCVkeHUh?=
Capan-2 NF\pdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO4WnM4UUN3ME2xOE4{PzF2IN88US=> MUPTRW5ITVJ?
BALL-1 M4\MU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zBZmlEPTB;MUSuOFY3PSEQvF2= MUTTRW5ITVJ?
LS-1034 NVTSTWNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF2Lk[xOVIh|ryP NUCwTYZvW0GQR1XS
U-118-MG NInhOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITkfmRKSzVyPUG0MlY{OSEQvF2= NFnjXYVUSU6JRWK=
NCI-H630 NXzUdmdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF2Lk[1Olgh|ryP NHnze2FUSU6JRWK=
OVCAR-8 NUDOZYtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XUO2lEPTB;MUSuO|IxOSEQvF2= MnnLV2FPT0WU
NCI-H2347 NITjbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUewenBOUUN3ME2xOE45OjNizszN MYjTRW5ITVJ?
BT-549 NV3CW45jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS0SoZKSzVyPUG0MlgzQDRizszN NIHLO|RUSU6JRWK=
LB831-BLC NX\CSGFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITYbppKSzVyPUG0Mlg6OzRizszN NX;GcGl7W0GQR1XS
NCI-H661 NV7GWpVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHBb3BuUUN3ME2xOE46PTlizszN M4n4N3NCVkeHUh?=
MKN7 M3;Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzJN3hKSzVyPUG1MlAxQTNizszN MoX3V2FPT0WU
U-87-MG M4K4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXVVo5KSzVyPUG1MlA5QTdizszN MmfqV2FPT0WU
OVCAR-4 M1rrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3GyZWlEPTB;MUWuNVQzPCEQvF2= MWnTRW5ITVJ?
OE33 MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHWVoRCUUN3ME2xOU4yPzFzIN88US=> NWPYUXByW0GQR1XS
EC-GI-10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe4VZVKSzVyPUG1MlI{PTdizszN NVrpcmJiW0GQR1XS
AM-38 MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2GwUmlEPTB;MUWuNlcyPyEQvF2= M{LFWnNCVkeHUh?=
NCI-H1563 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TBNmlEPTB;MUWuN|Q6KM7:TR?= NEPPfoRUSU6JRWK=
SCC-4 NXrRd5V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXXNmpWUUN3ME2xOU41OTB|IN88US=> MmLnV2FPT0WU
Detroit562 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD0TWM2OD1zNT60OVQ4KM7:TR?= M171TXNCVkeHUh?=
PC-14 MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIry[phKSzVyPUG1MlQ5PjZizszN NH3tRopUSU6JRWK=
ES3 M1rRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTFTWM2OD1zNT61N|Yh|ryP NHTr[ZdUSU6JRWK=
OCI-AML2 M1W2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL5TWM2OD1zNT63OlE1KM7:TR?= NFvlS45USU6JRWK=
LU-134-A Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:2TWM2OD1zNT65NFE5KM7:TR?= MlHpV2FPT0WU
SAS M3LxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;nPG5KSzVyPUG1Mlk{PzNizszN M1PnTHNCVkeHUh?=
TGBC11TKB M3zqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz1TWM2OD1zNT65OFE1KM7:TR?= MYHTRW5ITVJ?
HOP-62 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXLTJpKSzVyPUG1Mlk2QTdizszN MWXTRW5ITVJ?
G-401 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ROWlEPTB;MUWuPVY1QSEQvF2= NIn2OpJUSU6JRWK=
NCI-H28 NE\3[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD1fplKSzVyPUG2MlA5PTZizszN MnfmV2FPT0WU
A204 NW\FV2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LxcWlEPTB;MU[uNlAxPiEQvF2= NEHNfnNUSU6JRWK=
NCI-H1299 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjKVHBKSzVyPUG2MlIzQTFizszN M3;CfnNCVkeHUh?=
VMRC-RCZ Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fzSGlEPTB;MU[uNlU6OiEQvF2= M3rPcnNCVkeHUh?=
BxPC-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3jcHRKSzVyPUG2MlI5PTZizszN M4C1dHNCVkeHUh?=
NCI-H2228 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfuOJpOUUN3ME2xOk42OTV6IN88US=> Mlz1V2FPT0WU
NCI-H23 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnnXFhmUUN3ME2xOk43ODd6IN88US=> NYnDb2tDW0GQR1XS
NKM-1 NWXyTpdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP2eGdKSzVyPUG3MlAyQDlizszN MmTpV2FPT0WU
KYSE-70 MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF5LkK4PUDPxE1? NXnleZJpW0GQR1XS
BB49-HNC NInoSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF5LkW2PFYh|ryP M2Lpd3NCVkeHUh?=
SCC-15 NEjUVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF5Lki0O|Mh|ryP NXy4W3BqW0GQR1XS
D-247MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHNS5NDUUN3ME2xO{46OjR5IN88US=> Ml;MV2FPT0WU
BB30-HNC NEe4T41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXjbIY5UUN3ME2xPE4xOzF6IN88US=> MUPTRW5ITVJ?
CAL-85-1 M1\sNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF6LkG4NFkh|ryP MYnTRW5ITVJ?
HT-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLUWlEPTB;MUiuN|k4PyEQvF2= NYfmVoF7W0GQR1XS
KYSE-410 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqyTWM2OD1zOD60OVc4KM7:TR?= NXHjT|BiW0GQR1XS
SW982 NGDyb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX23[IFoUUN3ME2xPE42PjR7IN88US=> MV3TRW5ITVJ?
SW962 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHWRZlKSzVyPUG4MlU4ODJizszN Mnu2V2FPT0WU
Ramos-2G6-4C10 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXOR25HUUN3ME2xPE42QTJ5IN88US=> MYHTRW5ITVJ?
OC-314 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz6eWRKSzVyPUG4Mlc{QDRizszN NWXjW3RFW0GQR1XS
LS-123 NWDrNox[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF6Lke5NFEh|ryP NHjsclNUSU6JRWK=
D-502MG NUn6dIpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjxe4RKSzVyPUG4MlgyOzlizszN NUi1WIpVW0GQR1XS
RO82-W-1 NXLNXHpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDHPJpKSzVyPUG4MlgzQDhizszN MlHVV2FPT0WU
HuO9 NUHTZmg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4qzSWlEPTB;MUmuNVM4QSEQvF2= M2PBbHNCVkeHUh?=
ETK-1 NVjBfHpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnNb5VKSzVyPUG5MlE5OjdizszN MY\TRW5ITVJ?
SNU-387 NITxdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DPWWlEPTB;MUmuNVg5QSEQvF2= MUPTRW5ITVJ?
SW1573 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF7LkG5Olkh|ryP MmTQV2FPT0WU
NTERA-S-cl-D1 M4nu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF7LkKwNFch|ryP MnyzV2FPT0WU
SF126 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnyTWM2OD1zOT6zOVAzKM7:TR?= MmThV2FPT0WU
Calu-3 M4[3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzYTWM2OD1zOT60NlM4KM7:TR?= MmPzV2FPT0WU
NCI-H1048 M{jkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC3TWM2OD1{MD6zNlY3KM7:TR?= NH3ZT45USU6JRWK=
NCI-H226 NXLLTVNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDKNG86UUN3ME2yNE41Ozl7IN88US=> NUnNOng{W0GQR1XS
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SF539 NYq1PIt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13tUWlEPTB;MkCuOVE4OiEQvF2= M2raWXNCVkeHUh?=
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Becker Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjCW4pKSzVyPUKxMlEyOThizszN M1vKSXNCVkeHUh?=
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TI-73 NWr2V|NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHNS2FIUUN3ME2yNk4{OjhizszN NHzhRotUSU6JRWK=
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A704 NXTjSIRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLiTWM2OD1{Mz62NVA{KM7:TR?= MknWV2FPT0WU
LC-2-ad NUHud2FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ|Lk[xOFch|ryP NVTXUHBXW0GQR1XS
VM-CUB-1 NG\zUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ|LkezOFEh|ryP M1nw[HNCVkeHUh?=
PC-3 NHv4THBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq3TWM2OD1{ND6wOVI3KM7:TR?= M37qcnNCVkeHUh?=
HEL NH;aeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3WXYlKSzVyPUK0MlA5PjVizszN MkTvV2FPT0WU
ABC-1 M3XV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\QTWM2OD1{ND6yO|I6KM7:TR?= MkHWV2FPT0WU
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MZ1-PC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTTTmxvUUN3ME2yOE43QDdizszN NGrnSnNUSU6JRWK=
NCI-H69 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDRSndKSzVyPUK0Mlc{PTRizszN MYLTRW5ITVJ?
TE-1 NFvOcZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ3LkC0PVkh|ryP NIDIclBUSU6JRWK=
EW-3 NH74cYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrpTWM2OD1{NT6xNVMh|ryP M2XvdnNCVkeHUh?=
PANC-08-13 NYnMfGRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTrTWM2OD1{NT64NVA{KM7:TR?= NH2xSZZUSU6JRWK=
NMC-G1 NIraRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;YTZFUUUN3ME2yOk4xODh6IN88US=> MVXTRW5ITVJ?
BT-20 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj2S5c2UUN3ME2yOk41PTR|IN88US=> MnLTV2FPT0WU
TGBC24TKB NHrpdoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\W[YtKSzVyPUK2Mlc{OzFizszN NGTlVWpUSU6JRWK=
TE-11 NX;YWIl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TNOGlEPTB;Mk[uPVg6PSEQvF2= MXLTRW5ITVJ?
ESS-1 M1LlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\OO4JRUUN3ME2yO{4{OjF4IN88US=> NELrU5lUSU6JRWK=
JVM-3 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ5Lk[0O|Uh|ryP MUDTRW5ITVJ?
C3A MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnoOXpKSzVyPUK3Mlg1QTZizszN NV\aPHc3W0GQR1XS
MDA-MB-157 M2HBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\CSnBLUUN3ME2yO{45PzV|IN88US=> NFfX[IRUSU6JRWK=
KLE NEHS[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LqWWlEPTB;MkiuNVA2QCEQvF2= NVrvToduW0GQR1XS
ES1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\lPZpvUUN3ME2yPE4yQDN6IN88US=> MVLTRW5ITVJ?
CAL-120 NU\DZZBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ6LkO5PVkh|ryP NX;xRVhKW0GQR1XS
NCI-N87 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXUeJg5UUN3ME2yPE42OTB3IN88US=> MofoV2FPT0WU
RPMI-8226 NXzrOHB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJ7LkG4OFMh|ryP NX\WO5lzW0GQR1XS
COR-L88 NHnSPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LEbmlEPTB;MkmuNlQyQSEQvF2= M4HPOXNCVkeHUh?=
UACC-893 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfIUnBKSzVyPUK5MlMyOzdizszN NEnYcINUSU6JRWK=
C8166 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\MNmlEPTB;MkmuPVk6PiEQvF2= NInqWIZUSU6JRWK=
J82 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u2dGlEPTB;M{CuPFE1PyEQvF2= MlnMV2FPT0WU
PFSK-1 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHK[JBKSzVyPUOxMlA3PTlizszN M2D0PXNCVkeHUh?=
COLO-684 NILnco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;uWFBKSzVyPUOxMlQ{PzRizszN NXTFRo5XW0GQR1XS
CAL-72 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNzLkW3Nlkh|ryP NInIZVhUSU6JRWK=
SNB75 NEfiTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC0TWM2OD1|MT64PVch|ryP Mn;wV2FPT0WU
MDA-MB-415 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnuN3FzUUN3ME2zNU46PzZ{IN88US=> NHzRcm5USU6JRWK=
SiHa MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKxTWM2OD1|Mj60O|EyKM7:TR?= MWLTRW5ITVJ?
NCI-H1648 M1ztSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN{LkmzOFUh|ryP MVfTRW5ITVJ?
EFO-21 M{LHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjuTWM2OD1|Mz6wNFUh|ryP MXnTRW5ITVJ?
HCC38 NYfF[ll1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPEW5FKSzVyPUOzMlM5PDFizszN M4DFZXNCVkeHUh?=
IA-LM NEj4b4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjITWM2OD1|Mz63PFg6KM7:TR?= MlTuV2FPT0WU
CTV-1 M3rvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLNPHlJUUN3ME2zN{46Pzh4IN88US=> NHXsZ|RUSU6JRWK=
NCI-H446 M3T1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXLTWM2OD1|ND6yOlg6KM7:TR?= NGC0[JlUSU6JRWK=
IST-SL1 NHnDW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;uSHFKSzVyPUO0Mlc1ODhizszN MmPRV2FPT0WU
EW-22 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTN2Lke3OVkh|ryP NYPrZWZOW0GQR1XS
JEG-3 NFWyTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7xfJNKSzVyPUO2MlE4PjZizszN NYCydmtnW0GQR1XS
LU-65 NHPhNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7FfodKSzVyPUO2MlI6QDVizszN M4TCNnNCVkeHUh?=
NCI-H596 M124Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C4fmlEPTB;M{[uPVU6OSEQvF2= M4\aPXNCVkeHUh?=
KNS-81-FD MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX72XXE4UUN3ME2zO{4yPDVizszN MV;TRW5ITVJ?
NCI-H1793 Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nWZWlEPTB;M{euO|A5PiEQvF2= MYPTRW5ITVJ?
NCI-H460 NGnDR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTKU2FzUUN3ME2zPE4xQDd|IN88US=> MmLnV2FPT0WU
MPP-89 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H0SGlEPTB;M{muOVg5PiEQvF2= MYjTRW5ITVJ?
D-542MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN7Lki0N|Yh|ryP NYTtUZoxW0GQR1XS
JAR NGC0RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRyLkS3NFUh|ryP NYm1U5ROW0GQR1XS
NCI-H209 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHztc4NKSzVyPUSwMlY4PyEQvF2= Mn6wV2FPT0WU
G-402 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HuN2lEPTB;NEGuN|k6OyEQvF2= Mn[4V2FPT0WU
IST-MES1 NVrkcmZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITRfIpKSzVyPUSyMlE6OzVizszN MYfTRW5ITVJ?
Daoy M2jUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR{LkW0O|Eh|ryP NH3ERYNUSU6JRWK=
EW-11 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTR|LkGyNVEh|ryP MYrTRW5ITVJ?
Saos-2 NIDBeWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTR|LkG1N|ch|ryP M4PkSnNCVkeHUh?=
no-10 M2jxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vxdGlEPTB;NEOuNVcxOiEQvF2= M33PcXNCVkeHUh?=
HCC1395 NFKx[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR|LkS2OFQh|ryP NYPaZW5ZW0GQR1XS
HCE-4 NF7pdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PXfmlEPTB;NEOuO|Y3PCEQvF2= MofMV2FPT0WU
EW-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR|LkiwOFkh|ryP NESwU2xUSU6JRWK=
OCUB-M NVPrcZAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTR2LkO2N|gh|ryP MYPTRW5ITVJ?
IGR-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2niRmlEPTB;NESuOFEyPSEQvF2= NUK5RoVMW0GQR1XS
NCI-H1838 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTR2LkSzOFkh|ryP M135TXNCVkeHUh?=
NCI-H2405 NVHKWG9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXHb45KSzVyPUS0MlU{PCEQvF2= NYXUSmYyW0GQR1XS
GB-1 NYXqdZFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTR2Lke0OlMh|ryP M{LQe3NCVkeHUh?=
MG-63 NGL6PJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LLbGlEPTB;NE[uNFY6PiEQvF2= MYTTRW5ITVJ?
KP-N-YN NGrOcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXMTWM2OD12Nj60Olc6KM7:TR?= MVrTRW5ITVJ?
no-11 NF7FbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzZmRKSzVyPUS3MlAzPDRizszN NYnoRo9UW0GQR1XS
SW948 MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LTfGlEPTB;NEeuN|M4PyEQvF2= M2n4ZnNCVkeHUh?=
CAMA-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrLRoJyUUN3ME20O{4{PDN6IN88US=> NH75NI5USU6JRWK=
HCC1187 NFjYOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ftXGlEPTB;NEeuOVEh|ryP MXHTRW5ITVJ?
D-392MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTR5Lk[1NVYh|ryP NWHXN413W0GQR1XS
647-V MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR7LkO0NVQh|ryP Mn22V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

+ Expand

MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

+ Expand
  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

+ Expand
  • Animal Models: PTC cells in athymic mice
  • Formulation: Cremophor EL–95% ethanol (50:50) and dilutes with water
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID