PD184352 (CI-1040)

Catalog No.S1020

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

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In DMSO USD 140 In stock
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Cited by 62 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 NUPhUG1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXoSFhIUUN3ME2wMlAzOjd4IN88US=> NWnibnlYW0GQR1XS
CHP-212 NUnSRYdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTtUY5yUUN3ME2wMlAzQDh3IN88US=> NF;HNoZUSU6JRWK=
EoL-1-cell MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfoUZBKSzVyPUCuNFQyPTJizszN NEPlNoRUSU6JRWK=
DU-4475 NIjXNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:wTWM2OD1yLkC3OVk6KM7:TR?= M1;2enNCVkeHUh?=
MMAC-SF MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMUC5O|Qh|ryP M{DEO3NCVkeHUh?=
AGS M3nI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofHTWM2OD1yLkGxO|E{KM7:TR?= NVzrUGlnW0GQR1XS
M14 NEXVU2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjmTWM2OD1yLkG1OFY5KM7:TR?= NHj3N4dUSU6JRWK=
CP50-MEL-B MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\4TWM2OD1yLkG3NlU1KM7:TR?= MWrTRW5ITVJ?
C32 M{PDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rKNmlEPTB;MD6xPVA4OiEQvF2= M3zZcXNCVkeHUh?=
KMOE-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi5W2tKSzVyPUCuNVk4QTVizszN MkGzV2FPT0WU
A101D M{P2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojTTWM2OD1yLkKxOEDPxE1? MX3TRW5ITVJ?
KM12 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX0TWM2OD1yLkK0NFU4KM7:TR?= MXjTRW5ITVJ?
HSC-4 M2Lac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfKNoxwUUN3ME2wMlI1Ozl3IN88US=> MVvTRW5ITVJ?
NOMO-1 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMkW3OFIh|ryP MXTTRW5ITVJ?
MZ7-mel M1rtWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\zTWM2OD1yLkK2N|Qh|ryP NYLoWXB5W0GQR1XS
ACN M4n5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG5bVdKSzVyPUCuNlY4OzdizszN NEm4SYtUSU6JRWK=
MEL-HO M4\NWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMke2OVIh|ryP NVzrWpFMW0GQR1XS
BHT-101 NIi0PVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[4TWM2OD1yLkK4OlA3KM7:TR?= NUWycXdUW0GQR1XS
SK-MEL-28 M3PTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTuToJEUUN3ME2wMlMxPDB7IN88US=> NXi3d|UyW0GQR1XS
KG-1 M{jVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwM{C2Olgh|ryP NHLaS3RUSU6JRWK=
COLO-679 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwM{K3NkDPxE1? NUPjNoU6W0GQR1XS
SK-MEL-24 NV2yOmRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwM{K4NVMh|ryP M1XkV3NCVkeHUh?=
G-361 M{PmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7nU49rUUN3ME2wMlM3Pzl3IN88US=> MWjTRW5ITVJ?
KY821 NGfue2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PKOmlEPTB;MD6zO|kyKM7:TR?= Ml;WV2FPT0WU
KASUMI-1 M3HGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFztVYhKSzVyPUCuN|k6KM7:TR?= NUPkSpg1W0GQR1XS
HL-60 NXnycVdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrBTWM2OD1yLkSxNVA4KM7:TR?= NUPpNmRiW0GQR1XS
K5 NHv5XnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X6Z2lEPTB;MD60N|EyPyEQvF2= Mm\PV2FPT0WU
KU812 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzGTWM2OD1yLkS1Nlk6KM7:TR?= MUjTRW5ITVJ?
SH-4 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHWXVJFUUN3ME2wMlQ3OjV4IN88US=> M3:2bXNCVkeHUh?=
HTC-C3 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXsTWM2OD1yLkS2OVMyKM7:TR?= MnruV2FPT0WU
CP66-MEL MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7rU2pKSzVyPUCuOFg5ODlizszN MkTIV2FPT0WU
WM-115 M1j4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm2cJpXUUN3ME2wMlQ6OjV5IN88US=> NVrrVlBtW0GQR1XS
A2780 NWX0eFQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwNEm4NlMh|ryP MoHqV2FPT0WU
P12-ICHIKAWA Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXNdphRUUN3ME2wMlYyOjJzIN88US=> MU\TRW5ITVJ?
HMV-II NH7ue3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwNkS0OlUh|ryP MlXVV2FPT0WU
HT-144 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvRTWM2OD1yLk[0OlU4KM7:TR?= MVvTRW5ITVJ?
LB2518-MEL NHfPcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXK2d4RwUUN3ME2wMlcyPjN{IN88US=> NWixbY5ZW0GQR1XS
NCI-SNU-1 NGjNenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHhTWM2OD1yLke1OFM{KM7:TR?= NIrKXnpUSU6JRWK=
C2BBe1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwOEGwNlMh|ryP NH;DRpBUSU6JRWK=
PSN1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PpZmlEPTB;MD65OlE6PiEQvF2= MYPTRW5ITVJ?
UACC-257 NH\lZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwOU[0O|Mh|ryP MVrTRW5ITVJ?
RVH-421 NX;TXYNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TofmlEPTB;MD65O|E5KM7:TR?= MmWxV2FPT0WU
GP5d MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfRT|RKSzVyPUCuPVg{ODhizszN NWCzUWliW0GQR1XS
TYK-nu MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f4dWlEPTB;MT6wN|E4OiEQvF2= MmnXV2FPT0WU
SK-N-AS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwMEe5OFch|ryP MUjTRW5ITVJ?
SW620 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjLRphKSzVyPUGuNVM2OzRizszN MlHRV2FPT0WU
HuP-T4 NFvXd2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvRZYVKSzVyPUGuNVg{PTlizszN MlzvV2FPT0WU
A549 NFqw[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwMUm1O|Yh|ryP M3nteXNCVkeHUh?=
Mewo NWLENmN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwMkCyO|Yh|ryP MlTqV2FPT0WU
ONS-76 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK4eW9lUUN3ME2xMlIzODR7IN88US=> M2X5[HNCVkeHUh?=
SK-MEL-1 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3JWYtKSzVyPUGuNlM1OTlizszN MWjTRW5ITVJ?
RCM-1 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XHbGlEPTB;MT6yOFA1PyEQvF2= M{TKPHNCVkeHUh?=
H-EMC-SS M{DCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHQcoZKSzVyPUGuNlk3ODhizszN MXXTRW5ITVJ?
NCI-H2291 NIDN[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwM{K1N|Yh|ryP MkPrV2FPT0WU
SW1463 NFS3SodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFwM{O3NlEh|ryP NHz4WZdUSU6JRWK=
LS-411N MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK0cW0xUUN3ME2xMlQxPTF5IN88US=> NEPRUXlUSU6JRWK=
BV-173 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnue2hpUUN3ME2xMlQ1ODF3IN88US=> NYPlZWNqW0GQR1XS
LS-513 MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLGfHpxUUN3ME2xMlQ2OTl{IN88US=> MlzrV2FPT0WU
LoVo NYTkeXpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjMTWM2OD1zLkS2N|k6KM7:TR?= MnPBV2FPT0WU
HO-1-N-1 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPFTWM2OD1zLkWxOlM1KM7:TR?= MXzTRW5ITVJ?
ML-2 M3Lab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwNUK4Olgh|ryP MkPLV2FPT0WU
NCI-H1437 NHnUc4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DTVWlEPTB;MT61OVI4PSEQvF2= M3;YWXNCVkeHUh?=
SW1116 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwNU[zPVgh|ryP NHO0NpRUSU6JRWK=
A4-Fuk MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLZbpdKSzVyPUGuOVcxPDVizszN MYPTRW5ITVJ?
HD-MY-Z MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDTTWM2OD1zLkW3N|c3KM7:TR?= NEnPfnFUSU6JRWK=
SK-MEL-2 NV64Z4Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwNUe0OVkh|ryP M131[HNCVkeHUh?=
RT-112 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofFTWM2OD1zLkW4PVUzKM7:TR?= Mlj5V2FPT0WU
COLO-829 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSwTWM2OD1zLk[yNlMzKM7:TR?= MXPTRW5ITVJ?
OVCAR-5 NHfTOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjRU|czUUN3ME2xMlc4Pjh5IN88US=> MnzsV2FPT0WU
NB69 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHaXGlKSzVyPUGuO|g1PjlizszN M1niTHNCVkeHUh?=
NCI-H292 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HzO2lEPTB;MT64OlY6QSEQvF2= M4HrTHNCVkeHUh?=
LOXIMVI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TYS2lEPTB;MT64PVQzPyEQvF2= NXT3T5p6W0GQR1XS
BPH-1 NWO3WVdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvTfHJjUUN3ME2xMlg6PTlzIN88US=> M3j4XXNCVkeHUh?=
A375 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFroPIhKSzVyPUGuPFk4OTRizszN MYXTRW5ITVJ?
LCLC-97TM1 NHyyVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3LZYFTUUN3ME2xMlkzOjV4IN88US=> MX7TRW5ITVJ?
RXF393 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzoe|FKSzVyPUGuPVc5QDdizszN MXLTRW5ITVJ?
HCC70 Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXxTWM2OD1{LkCyOFI3KM7:TR?= NXq5[Y9HW0GQR1XS
EM-2 M1vJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW3TWM2OD1{LkC3NVk5KM7:TR?= MmXVV2FPT0WU
MZ2-MEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHtcFVKSzVyPUKuNVEyOjdizszN NFHCPWtUSU6JRWK=
HN Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfVTWM2OD1{LkG2Nlc5KM7:TR?= NXe0cFE4W0GQR1XS
A2058 M4ThfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULCS45qUUN3ME2yMlE6Ojd7IN88US=> M2nDfXNCVkeHUh?=
NB7 M37XWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP5fpk3UUN3ME2yMlM1ODh4IN88US=> M1XNTHNCVkeHUh?=
DOK M2\ibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHETWM2OD1{LkO1O|c{KM7:TR?= MUfTRW5ITVJ?
CAL-27 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfWVmlFUUN3ME2yMlM6OjN4IN88US=> Mnz5V2FPT0WU
BB65-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXVTWM2OD1{LkSwOlc1KM7:TR?= NUPDb5NuW0GQR1XS
RD M4THS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwNES3NlMh|ryP NE\MdmJUSU6JRWK=
KNS-62 NFXjUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7QTWM2OD1{LkWxNVY1KM7:TR?= MYPTRW5ITVJ?
EW-13 NXfDOYdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqzRXFFUUN3ME2yMlU3OzN7IN88US=> MkfXV2FPT0WU
DB MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNUi3PFgh|ryP M1Hrc3NCVkeHUh?=
HCC2218 M17IbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L5VGlEPTB;Mj62OFc4QCEQvF2= M1zQXXNCVkeHUh?=
L-363 NVjFb2xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjueZJGUUN3ME2yMlc1OzdizszN M2jnNnNCVkeHUh?=
CHL-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzVTWM2OD1{LkiwO|g2KM7:TR?= MmSzV2FPT0WU
BFTC-905 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WwNWlEPTB;Mj64NlU{KM7:TR?= MX7TRW5ITVJ?
HCE-T NIPlSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJwOEOyOlQh|ryP M2n5SXNCVkeHUh?=
COLO-792 NVPFdJB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrDWGpkUUN3ME2yMlg1ODJ5IN88US=> MV3TRW5ITVJ?
LB2241-RCC MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwOEW4PVMh|ryP M4O0eXNCVkeHUh?=
CAL-39 M1zzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TJZ2lEPTB;Mj64PVk6QSEQvF2= NVjzdoYyW0GQR1XS
T-24 NEPqSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XvS2lEPTB;Mj65NVEyOiEQvF2= NYXHdmRnW0GQR1XS
NCI-H727 M1PzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKxVmJ3UUN3ME2yMlkyPzl4IN88US=> NEP5e5lUSU6JRWK=
Ca9-22 NXLkNpBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPYU|JKSzVyPUKuPVczPTVizszN NF36cHFUSU6JRWK=
MIA-PaCa-2 NFzIbnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELOOplKSzVyPUOuNFA4QDFizszN MnnHV2FPT0WU
HT-1080 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnsN2dkUUN3ME2zMlAyQTl5IN88US=> MkPHV2FPT0WU
D-423MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vLVWlEPTB;Mz6wO|c2OyEQvF2= NEPtd4tUSU6JRWK=
LAMA-84 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHlTWM2OD1|LkGzOVgh|ryP NFG3S5RUSU6JRWK=
SW780 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrUSpdKSzVyPUOuNVQzOjlizszN MYLTRW5ITVJ?
KU-19-19 M4\kPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTHTWM2OD1|LkG3NFM1KM7:TR?= MUTTRW5ITVJ?
COLO-741 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\UTWM2OD1|LkG4Olc{KM7:TR?= NWnkUZhtW0GQR1XS
HSC-3 NWPiUIV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\GTWM2OD1|LkKzNVUyKM7:TR?= M{XVNHNCVkeHUh?=
SN12C NI[yR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jzXGlEPTB;Mz6yOFcxOSEQvF2= MUDTRW5ITVJ?
786-0 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m1TWlEPTB;Mz6yO|I1OyEQvF2= NUPBUWFoW0GQR1XS
GAK MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[xWllpUUN3ME2zMlMzPTZzIN88US=> Mor4V2FPT0WU
PANC-03-27 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PTbmlEPTB;Mz6zOVA1PSEQvF2= NUTpSmo4W0GQR1XS
CTB-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzpc3VEUUN3ME2zMlQ4ODR5IN88US=> Mo[0V2FPT0WU
A427 NXLmRYVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjSTWM2OD1|LkW5OVU3KM7:TR?= M165WHNCVkeHUh?=
EGI-1 M4LaUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HMd2lEPTB;Mz62NFU5OyEQvF2= M1\lSXNCVkeHUh?=
U-2-OS MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHRdotKSzVyPUOuOlczPTZizszN MVHTRW5ITVJ?
NCI-SNU-5 NI\oeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HERmlEPTB;Mz62O|c{KM7:TR?= MWHTRW5ITVJ?
SK-LU-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv2O|RKSzVyPUOuOlg4QThizszN MU\TRW5ITVJ?
697 NHvPOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCzTWM2OD1|Lk[5OlA{KM7:TR?= Ml7SV2FPT0WU
HPAF-II M4Lidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTWNJFMUUN3ME2zMlc2PDlizszN MVXTRW5ITVJ?
NCI-H2087 NXj0fZg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLpTpZDUUN3ME2zMlg1Pjd{IN88US=> NUXvcIs6W0GQR1XS
SK-MEL-3 NGDRU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnPWm1KSzVyPUOuPFUyPTRizszN NXOzOXdVW0GQR1XS
CGTH-W-1 NXn0XFhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rRW2lEPTB;Mz64OVczPSEQvF2= MkHKV2FPT0WU
8505C NXS3bFloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNwOUCwO|gh|ryP Mnf1V2FPT0WU
GAMG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;rOXBbUUN3ME20MlAzOzd5IN88US=> MkWyV2FPT0WU
SW626 M1qyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;Tc3JPUUN3ME20MlA1PDhizszN MWnTRW5ITVJ?
CAL-62 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITndXlKSzVyPUSuNFc1OyEQvF2= NH3zXIlUSU6JRWK=
MHH-PREB-1 M3rvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnpTWM2OD12LkGyNVEyKM7:TR?= M2Tae3NCVkeHUh?=
RPMI-7951 NUDZV5hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTBSG03UUN3ME20MlI2PTh7IN88US=> NF32RVZUSU6JRWK=
HOP-92 NWX0fpB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX2TWM2OD12LkK1Olch|ryP NFrablNUSU6JRWK=
MDA-MB-231 MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnsTWM2OD12LkK5NlI{KM7:TR?= MVPTRW5ITVJ?
LAN-6 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LqT2lEPTB;ND6zNVY{PyEQvF2= NVKwXmxVW0GQR1XS
ALL-PO NWPz[JlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTRwM{[xOVYh|ryP MmL1V2FPT0WU
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IGROV-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DnSmlEPTB;ND60OVE4OSEQvF2= MW\TRW5ITVJ?
NCI-H358 M3r2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7kTWM2OD12LkS1N|g2KM7:TR?= MYXTRW5ITVJ?
NB5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[5TWM2OD12Lk[wN|Y6KM7:TR?= M3m2N3NCVkeHUh?=
NCI-H747 NVfPdnVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDLXJR7UUN3ME20MlY5QDB5IN88US=> NWnaOpZmW0GQR1XS
NH-12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwN{G2NlUh|ryP Ml7TV2FPT0WU
LB1047-RCC MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7XWohKSzVyPUSuO|M5OTVizszN NYm0[HpVW0GQR1XS
EFO-27 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OyOmlEPTB;ND63PFY3PyEQvF2= MYLTRW5ITVJ?
EPLC-272H MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD12Lkm5OlY6KM7:TR?= Ml;WV2FPT0WU
CAL-54 NI\u[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\RPGlEPTB;NT6wNlY6PSEQvF2= NGTOcnpUSU6JRWK=
H4 M2PTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknWTWM2OD13LkC0NlU2KM7:TR?= NIiwbIpUSU6JRWK=
MOLT-13 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjKSXFKSzVyPUWuNFY4PzZizszN NVfCSJNqW0GQR1XS
CAL-33 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTFTWM2OD13LkGyN|E4KM7:TR?= NXzCNIR2W0GQR1XS
23132-87 NF\ne5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnzc5dKSzVyPUWuNVY5PzJizszN M{\ycnNCVkeHUh?=
UM-UC-3 M3PsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Lib2lEPTB;NT6xPFA1PyEQvF2= NF3PWHNUSU6JRWK=
HuH-7 Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHxdIRKSzVyPUWuNlcyPDdizszN NVnFOGhRW0GQR1XS
BCPAP M3vMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTVwM{K5Olkh|ryP MYrTRW5ITVJ?
AsPC-1 M1HTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDT[mlOUUN3ME21MlM3PzZ|IN88US=> NGHOZ3pUSU6JRWK=
NCI-H1155 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLVTWM2OD13LkSwNFUyKM7:TR?= MXHTRW5ITVJ?
GT3TKB NGj6O4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvNco9bUUN3ME21MlQ3PTl6IN88US=> MVLTRW5ITVJ?
HCC2998 M1POfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS0dWNNUUN3ME21MlQ6OTB7IN88US=> NWPO[3ZDW0GQR1XS
NUGC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3TTWM2OD13LkS5N|AzKM7:TR?= Mkn6V2FPT0WU
Hs-578-T MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHxcYVKSzVyPUWuOVM4QTRizszN NXvrfIlVW0GQR1XS
FADU NEHOXmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTVwNUW3NlYh|ryP NWHOVnVCW0GQR1XS
NBsusSR MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7VSnNKSzVyPUWuOVcyPTVizszN M1uwTXNCVkeHUh?=
ME-180 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO3bXRKSzVyPUWuOVgxQTJizszN M1mwNHNCVkeHUh?=
SW1710 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\5T2lEPTB;NT62NVY2PCEQvF2= MXfTRW5ITVJ?
HuP-T3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3QTWM2OD13Lk[yNFI6KM7:TR?= Ml:0V2FPT0WU
HOS MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki0TWM2OD13Lk[yPVI{KM7:TR?= M1PXcHNCVkeHUh?=
PA-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzQTWM2OD13Lk[0NlY2KM7:TR?= MVvTRW5ITVJ?
LU-99A MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfHdGNKSzVyPUWuOlY1PTFizszN MlzjV2FPT0WU
RS4-11 NUPXO|dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nMeWlEPTB;NT62Olc4PSEQvF2= NILGXJpUSU6JRWK=
TE-8 NHrJO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD2XZFOUUN3ME21MlY5PTN5IN88US=> NXS0dYs3W0GQR1XS
RERF-LC-MS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnHTWM2OD13Lk[4PFA{KM7:TR?= MkTTV2FPT0WU
MEL-JUSO NYPPSYhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnOWYNKSzVyPUWuO|M4QCEQvF2= M{m2cXNCVkeHUh?=
SK-MES-1 NX:xTXJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTVwOEO1Nlgh|ryP Mn:yV2FPT0WU
D-263MG NV;Y[GhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rZe2lEPTB;NT64PFM2OSEQvF2= NGGzcXZUSU6JRWK=
NB10 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\qZXBpUUN3ME21Mlg6PDZizszN NEHKfIVUSU6JRWK=
SK-HEP-1 M3H5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTVwOUO0O|Eh|ryP NF3CV4dUSU6JRWK=
HT-29 M{fVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17WUmlEPTB;NT65PFEyQCEQvF2= M1HQfnNCVkeHUh?=
KYSE-140 MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TCUmlEPTB;Nj6wNlE5OiEQvF2= NXK2[Wp6W0GQR1XS
NCI-H1666 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPGTWM2OD14LkC4OFYyKM7:TR?= MXfTRW5ITVJ?
NCI-H1304 M2T6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfPdnpKSzVyPU[uNVk6PCEQvF2= MX\TRW5ITVJ?
RPMI-8866 M3faW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnaVW1KSzVyPU[uNlE{OTNizszN NVjNOlZxW0GQR1XS
MV-4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4exUGlEPTB;Nj6yN|E6QSEQvF2= M4LENHNCVkeHUh?=
A431 M1HXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;LW|dnUUN3ME22MlI1Ojl4IN88US=> MnT6V2FPT0WU
PANC-10-05 NFL0R5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW5TGxKSzVyPU[uNlg{PjNizszN Mn7GV2FPT0WU
TK10 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTZwM{K2NFQh|ryP NYmyVGhzW0GQR1XS
NCI-H1975 NHfIfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZwNEeyNVUh|ryP MnzkV2FPT0WU
A172 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD14LkS5NVc3KM7:TR?= M2HlN3NCVkeHUh?=
D-566MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFG5d3BKSzVyPU[uOVQ{ODNizszN MWLTRW5ITVJ?
NCI-H2122 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TDTWlEPTB;Nj62NVUzQCEQvF2= NFzJelBUSU6JRWK=
COR-L105 NIHvSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTZwNkWyO|Uh|ryP NVLnc|hYW0GQR1XS
AN3-CA NEPFOYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfv[HJUUUN3ME22MlY5PjRzIN88US=> Mkn5V2FPT0WU
Calu-6 NX\KTJRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLwWY9KSzVyPU[uO|k3QThizszN NH3LemRUSU6JRWK=
HCT-116 M1XaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ES4V{UUN3ME22MlgyOjZ2IN88US=> MWjTRW5ITVJ?
MHH-NB-11 NXznbJdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTZwOEWwNFIh|ryP NVvkcFltW0GQR1XS
MFE-280 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHvbVFYUUN3ME22Mlg2QTh|IN88US=> MofNV2FPT0WU
SW1088 M37Tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZwOUG5NVMh|ryP MYTTRW5ITVJ?
SW48 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTZwOUS1NUDPxE1? NWS3TpE3W0GQR1XS
HuCCT1 Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfBcnNKSzVyPUeuNFExOzdizszN NWXafm5yW0GQR1XS
ACHN NEH4fGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTdwMEK5OFMh|ryP M{fESXNCVkeHUh?=
8305C Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTdwMEm5PVUh|ryP M2fHWHNCVkeHUh?=
DoTc2-4510 M2L0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnraTWM2OD15LkGyNVUh|ryP M3nBeHNCVkeHUh?=
COR-L23 Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTdwMkS0NkDPxE1? MmDpV2FPT0WU
SK-MEL-30 MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHONlVKSzVyPUeuNlUxQDNizszN M37iWHNCVkeHUh?=
BE-13 NIfJRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zwcGlEPTB;Nz6zN|g{PCEQvF2= NHS2V3RUSU6JRWK=
GR-ST NEXHW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKyU|ZYUUN3ME23MlQxOTd2IN88US=> Mk\DV2FPT0WU
LU-135 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rtNWlEPTB;Nz61OVk{QSEQvF2= MUHTRW5ITVJ?
U-266 NV3OW2FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnG[4dNUUN3ME23MlU3Ojh4IN88US=> MVLTRW5ITVJ?
NCI-H1355 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTdwNUi2N|Uh|ryP NGnmOmRUSU6JRWK=
NB14 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OxTGlEPTB;Nz62OlY1OiEQvF2= M{P2bXNCVkeHUh?=
SCC-25 NXnPOFFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTdwN{C5JO69VQ>? NH;kOXFUSU6JRWK=
COLO-678 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q2eWlEPTB;Nz63NVA4PiEQvF2= M33MXnNCVkeHUh?=
TGBC1TKB Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnBZpdHUUN3ME23Mlg6Ozl6IN88US=> M1PEd3NCVkeHUh?=
IST-MEL1 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnRTWM2OD16LkCwOFA3KM7:TR?= M{HJUnNCVkeHUh?=
ECC10 NFXKdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX6TWM2OD16LkCzN|k2KM7:TR?= NIHVZVdUSU6JRWK=
EW-16 NITl[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi0dYk4UUN3ME24MlA5PDR3IN88US=> NXvpcIR2W0GQR1XS
DOHH-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWzTWM2OD16LkKwNFk2KM7:TR?= MnHtV2FPT0WU
NCI-H1581 Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7HW4VKSzVyPUiuNlY{OjNizszN M3\seHNCVkeHUh?=
TE-5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\rWmlEPTB;OD60NlQzQSEQvF2= NVe3S|B5W0GQR1XS
CAKI-1 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6yZ3JXUUN3ME24MlU4OjJ{IN88US=> NVW4V5ZwW0GQR1XS
A673 NVzK[3RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRThwNkOyNFIh|ryP M{mydXNCVkeHUh?=
CAL-12T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PnVWlEPTB;OD62OVc2OyEQvF2= MnSwV2FPT0WU
DBTRG-05MG Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRThwN{S4OVkh|ryP Ml;RV2FPT0WU
SK-N-FI NUHiN41PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHsR4NFUUN3ME24MlgyOzd7IN88US=> NUnjW3pkW0GQR1XS
K-562 NELwdFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XSWGlEPTB;OD64N|k2PyEQvF2= NF\k[mhUSU6JRWK=
SBC-1 NHy2T5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW4TWM2OD16Lki2OlQ2KM7:TR?= NIXxPZZUSU6JRWK=
ES4 NFHBXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRThwOE[4PFQh|ryP NV\6SGRxW0GQR1XS
MS-1 NHvvOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfkdJFPUUN3ME24Mlg4PTF5IN88US=> NGWwW3ZUSU6JRWK=
RKO MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:yV3pKSzVyPUiuPFkxPTdizszN MVjTRW5ITVJ?
NCI-H1693 NV;HZ3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDITWM2OD16LkmyNVch|ryP NIjGR2NUSU6JRWK=
SW954 NInPSIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Hzb2lEPTB;OD65Olk4QCEQvF2= NXi2emJNW0GQR1XS
SK-UT-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvJTWM2OD16Lkm3Olg{KM7:TR?= MnHCV2FPT0WU
T98G M2rzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxTmlEPTB;OD65PVg1PiEQvF2= MYfTRW5ITVJ?
NCI-H2126 NW\Ielh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELlU25KSzVyPUmuNFA5OjZizszN NVPtTYdFW0GQR1XS
TE-12 NXPxOHlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTlwMEOzOlch|ryP M1HFd3NCVkeHUh?=
DK-MG NX[xPIlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTlwMkGxPVEh|ryP NWHiV5RSW0GQR1XS
MEG-01 M4DZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTlwMkS5N|Eh|ryP MoDJV2FPT0WU
HCC1937 NHjDOIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjUTWM2OD17LkK5NFkyKM7:TR?= MX;TRW5ITVJ?
MKN45 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHlNIZ[UUN3ME25MlQ2ODZ3IN88US=> NW\sfmdTW0GQR1XS
NCI-H1792 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTlwNEWyNVkh|ryP MYTTRW5ITVJ?
SW1417 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTlwNU[4N|ch|ryP MVrTRW5ITVJ?
639-V MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vKZ2lEPTB;OT62OFM5QCEQvF2= NXXtNJZTW0GQR1XS
P30-OHK M4jiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfFTWM2OD17Lk[1N|E3KM7:TR?= MX\TRW5ITVJ?
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NCI-H1623 MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi1UohKSzVyPUGwMlY{PzlizszN MWPTRW5ITVJ?
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DJM-1 M2fycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\kNGlEPTB;MUGuNFM4QSEQvF2= MXjTRW5ITVJ?
U251 NV\WeoI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonPTWM2OD1zMT6wOFIh|ryP NEjVT4ZUSU6JRWK=
SBC-5 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG5TWM2OD1zMT6xOFY4KM7:TR?= MmK4V2FPT0WU
SW756 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnQTWM2OD1zMT6yNVU1KM7:TR?= NY\nW2ZRW0GQR1XS
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KYSE-450 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWzc4VKSzVyPUGxMlQxPTdizszN M3TEOnNCVkeHUh?=
KYSE-180 NGnPeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;RTWM2OD1zMT60PFIh|ryP M1XScXNCVkeHUh?=
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KYSE-270 M1fNS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFzLki3OFUh|ryP NXfvV3NOW0GQR1XS
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KALS-1 NEPRSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH1bFJwUUN3ME2xNk4xODF4IN88US=> NVPkSYZwW0GQR1XS
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HLE MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvYbG9RUUN3ME2xNk4xPTh3IN88US=> M{HKenNCVkeHUh?=
SJSA-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO3TWM2OD1zMj6wO|M2KM7:TR?= NHe2OpBUSU6JRWK=
SW1990 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TWdWlEPTB;MUKuNFkyOSEQvF2= NYLQZYNRW0GQR1XS
NOS-1 NXf3[5lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PKWGlEPTB;MUKuNVM2OiEQvF2= M4jUS3NCVkeHUh?=
GI-ME-N NELyZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PaNmlEPTB;MUKuNlE3OyEQvF2= NELhVGtUSU6JRWK=
NCI-H1703 NVLZfoFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF{LkK2NVYh|ryP NVW0Z4hKW0GQR1XS
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KYSE-510 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\LNGFKSzVyPUGyMlUxPzlizszN Mn72V2FPT0WU
BHY Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF{LkWzNFch|ryP MY\TRW5ITVJ?
TCCSUP M1PvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWxRWNsUUN3ME2xNk42PzV5IN88US=> MnrJV2FPT0WU
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BEN NVLtfod2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF{Lk[xOFMh|ryP M{PoSnNCVkeHUh?=
769-P MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDBZ4RKSzVyPUGyMlc6OjRizszN MWLTRW5ITVJ?
HT NVW4ZYNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF{LkizOFYh|ryP MYfTRW5ITVJ?
LXF-289 NGG5cpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zMemlEPTB;MUKuPVU{OSEQvF2= MnzuV2FPT0WU
OVCAR-3 M4myUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\HVmo5UUN3ME2xNk46PTZ5IN88US=> MlTaV2FPT0WU
ATN-1 M{fSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jyNWlEPTB;MUOuNFE5PCEQvF2= NGTxXo5USU6JRWK=
8-MG-BA NFq0VJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfxXmRUUUN3ME2xN{4xPDV3IN88US=> M4W3NnNCVkeHUh?=
SW13 M{TifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\HOpFQUUN3ME2xN{4yOTZ3IN88US=> NV\VOHJZW0GQR1XS
NCI-H1092 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PBNGlEPTB;MUOuNVYzKM7:TR?= M2XMUXNCVkeHUh?=
OAW-42 M{HMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\5TWM2OD1zMz6xPVM4KM7:TR?= M3fvfXNCVkeHUh?=
NCI-H2452 M2\Xdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j2PGlEPTB;MUOuNlE4PSEQvF2= NES4Z5JUSU6JRWK=
CAPAN-1 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz5SolHUUN3ME2xN{42PTF2IN88US=> M3n4RXNCVkeHUh?=
NCI-H2009 M13QTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF|LkW5NVkh|ryP MkftV2FPT0WU
SF268 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zxVmlEPTB;MUOuOlMzPiEQvF2= MmPXV2FPT0WU
GCIY MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPFdI9KSzVyPUGzMlY6OjdizszN NXfMfppzW0GQR1XS
OS-RC-2 M4Tadmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXNWHFCUUN3ME2xN{46PTBzIN88US=> MnvqV2FPT0WU
GCT NYCzV4dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu4OoNDUUN3ME2xN{46Pjl5IN88US=> MX;TRW5ITVJ?
NB17 M4jMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3VTWM2OD1zND6wPFUh|ryP MUfTRW5ITVJ?
NCI-H2030 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTzTWM2OD1zND6xOFY2KM7:TR?= M4TqU3NCVkeHUh?=
HC-1 NFi2TI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlftTWM2OD1zND6yNFg4KM7:TR?= NHLXV2hUSU6JRWK=
QIMR-WIL NUfEdIx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHiTWM2OD1zND6zOFEzKM7:TR?= M3XkbXNCVkeHUh?=
Capan-2 NXPSeoJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF2LkO3NVQh|ryP MYXTRW5ITVJ?
BALL-1 M4DSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrBb|lKSzVyPUG0MlQ3PjVizszN NUjNTm51W0GQR1XS
LS-1034 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnDc4pnUUN3ME2xOE43OTV{IN88US=> NF[4TlVUSU6JRWK=
U-118-MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnqempxUUN3ME2xOE43OzFizszN NGPYPYZUSU6JRWK=
NCI-H630 NI[5d4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF2Lk[1Olgh|ryP MVLTRW5ITVJ?
OVCAR-8 NFvyNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfjO|ExUUN3ME2xOE44OjBzIN88US=> M2fSOHNCVkeHUh?=
NCI-H2347 NHXFW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL4TWM2OD1zND64NlMh|ryP MYTTRW5ITVJ?
BT-549 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK0TWM2OD1zND64Nlg1KM7:TR?= NGrrS4hUSU6JRWK=
LB831-BLC MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1zND64PVM1KM7:TR?= M1HZZ3NCVkeHUh?=
NCI-H661 M1TCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvDSGpzUUN3ME2xOE46PTlizszN NGrY[4RUSU6JRWK=
MKN7 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7oPW9KSzVyPUG1MlAxQTNizszN NF3GPYRUSU6JRWK=
U-87-MG NWfGNI54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi0WWF[UUN3ME2xOU4xQDl5IN88US=> Mm\pV2FPT0WU
OVCAR-4 NHjLWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jZ[GlEPTB;MUWuNVQzPCEQvF2= NFviNYNUSU6JRWK=
OE33 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzDeYZFUUN3ME2xOU4yPzFzIN88US=> M4DIW3NCVkeHUh?=
EC-GI-10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfVTWM2OD1zNT6yN|U4KM7:TR?= MYnTRW5ITVJ?
AM-38 M4\MW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T5NWlEPTB;MUWuNlcyPyEQvF2= MoT0V2FPT0WU
NCI-H1563 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfjT4tYUUN3ME2xOU4{PDlizszN NFHUfoZUSU6JRWK=
SCC-4 M2\ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF3LkSxNFMh|ryP M4T3OnNCVkeHUh?=
Detroit562 NGToe5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTnb4FKSzVyPUG1MlQ2PDdizszN MX7TRW5ITVJ?
PC-14 M1HHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M331U2lEPTB;MUWuOFg3PiEQvF2= M1;IdXNCVkeHUh?=
ES3 M1\6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW3TWM2OD1zNT61N|Yh|ryP MoHkV2FPT0WU
OCI-AML2 NH\4U2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2CyO2lEPTB;MUWuO|YyPCEQvF2= M2LG[nNCVkeHUh?=
LU-134-A MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVZ2lEPTB;MUWuPVAyQCEQvF2= NEjEbY5USU6JRWK=
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TGBC11TKB MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF3Lkm0NVQh|ryP NV7JeI9xW0GQR1XS
HOP-62 NWjHNYYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTF3Lkm1PVch|ryP NYHsNIEyW0GQR1XS
G-401 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTF3Lkm2OFkh|ryP NIfyO4ZUSU6JRWK=
NCI-H28 MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LQ[WlEPTB;MU[uNFg2PiEQvF2= NWf6d3A1W0GQR1XS
A204 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDKcmxKSzVyPUG2MlIxODZizszN NXvDTlZuW0GQR1XS
NCI-H1299 NGL0SlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfvTWM2OD1zNj6yNlkyKM7:TR?= NIGzToVUSU6JRWK=
VMRC-RCZ Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLoWIVzUUN3ME2xOk4zPTl{IN88US=> NWrvNYt7W0GQR1XS
BxPC-3 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2iwOmlEPTB;MU[uNlg2PiEQvF2= MX\TRW5ITVJ?
NCI-H2228 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X6SmlEPTB;MU[uOVE2QCEQvF2= MnztV2FPT0WU
NCI-H23 NVLOWllqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfjeHJQUUN3ME2xOk43ODd6IN88US=> MmfhV2FPT0WU
NKM-1 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLOTWM2OD1zNz6wNVg6KM7:TR?= MkGxV2FPT0WU
KYSE-70 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPpb|k{UUN3ME2xO{4zQDlizszN NIS4XWpUSU6JRWK=
BB49-HNC NIPPWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljhTWM2OD1zNz61Olg3KM7:TR?= MYDTRW5ITVJ?
SCC-15 M{C0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H2TWlEPTB;MUeuPFQ4OyEQvF2= M3zSeHNCVkeHUh?=
D-247MG NEHqeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\mTWM2OD1zNz65NlQ4KM7:TR?= NFXGXJVUSU6JRWK=
BB30-HNC NET3XphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF6LkCzNVgh|ryP MlixV2FPT0WU
CAL-85-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPLTWM2OD1zOD6xPFA6KM7:TR?= MVTTRW5ITVJ?
HT-3 Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF6LkO5O|ch|ryP MVHTRW5ITVJ?
KYSE-410 NFuzSZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF6LkS1O|ch|ryP MV;TRW5ITVJ?
SW982 M2DIbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXnWpNKSzVyPUG4MlU3PDlizszN M{HQWnNCVkeHUh?=
SW962 NEHoO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTNd5JDUUN3ME2xPE42PzB{IN88US=> MX3TRW5ITVJ?
Ramos-2G6-4C10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rwV2lEPTB;MUiuOVkzPyEQvF2= MVrTRW5ITVJ?
OC-314 NFT4XIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF6LkezPFQh|ryP MoHnV2FPT0WU
LS-123 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS4WndKSzVyPUG4Mlc6ODFizszN MUfTRW5ITVJ?
D-502MG NV[yfHp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf2TWM2OD1zOD64NVM6KM7:TR?= MmHPV2FPT0WU
RO82-W-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r6Z2lEPTB;MUiuPFI5QCEQvF2= MlrCV2FPT0WU
HuO9 NIPk[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe3TWM2OD1zOT6xN|c6KM7:TR?= NUnrbnNOW0GQR1XS
ETK-1 MnHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm2TWM2OD1zOT6xPFI4KM7:TR?= MoPPV2FPT0WU
SNU-387 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf6TWM2OD1zOT6xPFg6KM7:TR?= NHG1WVhUSU6JRWK=
SW1573 NXn3eXpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\qfnVVUUN3ME2xPU4yQTZ7IN88US=> M4XzPXNCVkeHUh?=
NTERA-S-cl-D1 NYDheXNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKze3VOUUN3ME2xPU4zODB5IN88US=> M{i0VXNCVkeHUh?=
SF126 M3W0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPSWZNTUUN3ME2xPU4{PTB{IN88US=> MkXiV2FPT0WU
Calu-3 M4XxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXrTJpjUUN3ME2xPU41OjN5IN88US=> MUjTRW5ITVJ?
NCI-H1048 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJyLkOyOlYh|ryP Mn;GV2FPT0WU
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C3A MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rOTmlEPTB;MkeuPFQ6PiEQvF2= MXXTRW5ITVJ?
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KLE MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j4VGlEPTB;MkiuNVA2QCEQvF2= MmnRV2FPT0WU
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RPMI-8226 NIHyblZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ7LkG4OFMh|ryP NXPwSFJYW0GQR1XS
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C8166 M3nIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPKTJM5UUN3ME2yPU46QTl4IN88US=> M1;zRnNCVkeHUh?=
J82 Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjtbHZKSzVyPUOwMlgyPDdizszN NVzDb2w1W0GQR1XS
PFSK-1 M2DNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrCT|RKSzVyPUOxMlA3PTlizszN M{DOO3NCVkeHUh?=
COLO-684 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fvcWlEPTB;M{GuOFM4PCEQvF2= NXTJNY5RW0GQR1XS
CAL-72 NX\pd2dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1|MT61O|I6KM7:TR?= NHvIWldUSU6JRWK=
SNB75 Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\CXVlKSzVyPUOxMlg6PyEQvF2= MVjTRW5ITVJ?
MDA-MB-415 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTkfIFKSzVyPUOxMlk4PjJizszN MXrTRW5ITVJ?
SiHa NGDscnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrJTWM2OD1|Mj60O|EyKM7:TR?= Mmj6V2FPT0WU
NCI-H1648 MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHITWM2OD1|Mj65N|Q2KM7:TR?= MmTVV2FPT0WU
EFO-21 M{HrT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTN|LkCwOUDPxE1? M2LKe3NCVkeHUh?=
HCC38 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSxdVZkUUN3ME2zN{4{QDRzIN88US=> MkTvV2FPT0WU
IA-LM NWLufYVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN|Lke4PFkh|ryP M2mwbXNCVkeHUh?=
CTV-1 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN|Lkm3PFYh|ryP NVjMNYVuW0GQR1XS
NCI-H446 NInJeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTyTWM2OD1|ND6yOlg6KM7:TR?= Ml7XV2FPT0WU
IST-SL1 NH75V4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XPO2lEPTB;M{SuO|QxQCEQvF2= MWrTRW5ITVJ?
EW-22 NGPCUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHIbml1UUN3ME2zOE44PzV7IN88US=> MmnNV2FPT0WU
JEG-3 NIS5TpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j3UWlEPTB;M{[uNVc3PiEQvF2= NWr0cJkyW0GQR1XS
LU-65 NWrvT3FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;HTWM2OD1|Nj6yPVg2KM7:TR?= M4rnPXNCVkeHUh?=
NCI-H596 NF3GT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvZSoZ5UUN3ME2zOk46PTlzIN88US=> M3fNdnNCVkeHUh?=
KNS-81-FD NFjyOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjWNFZFUUN3ME2zO{4yPDVizszN NHToO2JUSU6JRWK=
NCI-H1793 NHq3WoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPaTWM2OD1|Nz63NFg3KM7:TR?= NXnhbVBFW0GQR1XS
NCI-H460 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHtXlI6UUN3ME2zPE4xQDd|IN88US=> MXPTRW5ITVJ?
MPP-89 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3fWNKSzVyPUO5MlU5QDZizszN NX3VSlQ3W0GQR1XS
D-542MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN7Lki0N|Yh|ryP NFm2fotUSU6JRWK=
JAR NEfzTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjWTWM2OD12MD60O|A2KM7:TR?= MnjVV2FPT0WU
NCI-H209 M4jOfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\tTWM2OD12MD62O|ch|ryP NWr0WnB6W0GQR1XS
G-402 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TpTGlEPTB;NEGuN|k6OyEQvF2= M3jqRXNCVkeHUh?=
IST-MES1 Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W4OWlEPTB;NEKuNVk{PSEQvF2= MnfqV2FPT0WU
Daoy M17qWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR{LkW0O|Eh|ryP NYLV[4F5W0GQR1XS
EW-11 M1:0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:yTWM2OD12Mz6xNlEyKM7:TR?= Ml7vV2FPT0WU
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HCE-4 M3zkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTR|Lke2OlQh|ryP NYrsZlB4W0GQR1XS
EW-1 M12zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfnfm5SUUN3ME20N{45ODR7IN88US=> NXjvbFdxW0GQR1XS
OCUB-M MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj0Und5UUN3ME20OE4{PjN6IN88US=> MkXvV2FPT0WU
IGR-1 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K1OmlEPTB;NESuOFEyPSEQvF2= NX30cndVW0GQR1XS
NCI-H1838 NX7DNFdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPtSIVKSzVyPUS0MlQ{PDlizszN MmXJV2FPT0WU
NCI-H2405 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzDTWM2OD12ND61N|Qh|ryP NUnBVoRZW0GQR1XS
GB-1 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTR2Lke0OlMh|ryP MV;TRW5ITVJ?
MG-63 MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf2N|lKSzVyPUS2MlA3QTZizszN NX;XV|RTW0GQR1XS
KP-N-YN M2fSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPDTWM2OD12Nj60Olc6KM7:TR?= M4rUdXNCVkeHUh?=
no-11 NGTKOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CxPWlEPTB;NEeuNFI1PCEQvF2= M{PrcnNCVkeHUh?=
SW948 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImxNJVKSzVyPUS3MlM{PzdizszN MlnzV2FPT0WU
CAMA-1 NIK5VIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTR5LkO0N|gh|ryP MUnTRW5ITVJ?
HCC1187 NFHxRoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnybnpKSzVyPUS3MlUyKM7:TR?= NIrzboVUSU6JRWK=
D-392MG M3v4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XqWmlEPTB;NEeuOlUyPiEQvF2= M{TxfnNCVkeHUh?=
647-V MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR7LkO0NVQh|ryP M1fNXXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

+ Expand

MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

+ Expand
  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

+ Expand
  • Animal Models: PTC cells in athymic mice
  • Formulation: Cremophor EL–95% ethanol (50:50) and dilutes with water
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID