PD184352 (CI-1040)

For research use only.

Catalog No.S1020

109 publications

PD184352 (CI-1040) Chemical Structure

CAS No. 212631-79-3

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis. Phase 2.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 140 In stock
USD 70 In stock
USD 120 In stock
USD 270 In stock
USD 670 In stock
USD 770 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's PD184352 (CI-1040) has been cited by 109 publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 NYjtWGI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XaSWlEPTB;MD6wNlI4PiEQvF2= NX3WcFRFW0GQR1XS
CHP-212 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSzUXdPUUN3ME2wMlAzQDh3IN88US=> NILlOIpUSU6JRWK=
EoL-1-cell MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrkfmZrUUN3ME2wMlA1OTV{IN88US=> NF\ncZJUSU6JRWK=
DU-4475 NF7UWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnacGVKSzVyPUCuNFc2QTlizszN MkPxV2FPT0WU
MMAC-SF MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPEeWZKSzVyPUCuNVA6PzRizszN M{LVXnNCVkeHUh?=
AGS M3;WSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ezd2lEPTB;MD6xNVcyOyEQvF2= NI\ON3ZUSU6JRWK=
M14 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMUW0Olgh|ryP M4HFWHNCVkeHUh?=
CP50-MEL-B MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTwN|FKSzVyPUCuNVczPTRizszN NXznOWJPW0GQR1XS
C32 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMUmwO|Ih|ryP NVvVRph{W0GQR1XS
KMOE-2 NVfNWXlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLBe2pVUUN3ME2wMlE6Pzl3IN88US=> M{PlOXNCVkeHUh?=
A101D M330Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrvTlIxUUN3ME2wMlIyPCEQvF2= NH7h[mpUSU6JRWK=
KM12 NFfsR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\uZmlEPTB;MD6yOFA2PyEQvF2= Mke3V2FPT0WU
HSC-4 M{K3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMkSzPVUh|ryP M{fjcXNCVkeHUh?=
NOMO-1 NF:4b3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG4PHo6UUN3ME2wMlI2PzR{IN88US=> M2m0fXNCVkeHUh?=
MZ7-mel M{HL[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMk[zOEDPxE1? M4DXOHNCVkeHUh?=
ACN NYPiRWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMk[3N|ch|ryP NGHQfoVUSU6JRWK=
MEL-HO Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTGO2w2UUN3ME2wMlI4PjV{IN88US=> NIXPWWpUSU6JRWK=
BHT-101 M1;0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMki2NFYh|ryP M2qwTXNCVkeHUh?=
SK-MEL-28 NH\qS2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\F[lhKSzVyPUCuN|A1ODlizszN MnmzV2FPT0WU
KG-1 NWHVWIVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TlOmlEPTB;MD6zNFY3QCEQvF2= NGDn[XFUSU6JRWK=
COLO-679 NIPHTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW3TlZZUUN3ME2wMlMzPzJizszN MXrTRW5ITVJ?
SK-MEL-24 NFzWZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\IOZJMUUN3ME2wMlMzQDF|IN88US=> MWXTRW5ITVJ?
G-361 M1jh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwM{[3PVUh|ryP M1PUc3NCVkeHUh?=
KY821 NWLyNnl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;UemFKSzVyPUCuN|c6OSEQvF2= NHnMcIxUSU6JRWK=
KASUMI-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTvUlZKSzVyPUCuN|k6KM7:TR?= MWjTRW5ITVJ?
HL-60 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDae41tUUN3ME2wMlQyOTB5IN88US=> NUP2[mw2W0GQR1XS
K5 M1W0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Ttc2lEPTB;MD60N|EyPyEQvF2= NUjOfHdRW0GQR1XS
KU812 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNEWyPVkh|ryP NV;xSmZtW0GQR1XS
SH-4 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rGZmlEPTB;MD60OlI2PiEQvF2= NH;X[Y5USU6JRWK=
HTC-C3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL0TWM2OD1yLkS2OVMyKM7:TR?= MYfTRW5ITVJ?
CP66-MEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNEi4NFkh|ryP MUnTRW5ITVJ?
WM-115 M1Prb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjNNXJSUUN3ME2wMlQ6OjV5IN88US=> M3Ox[XNCVkeHUh?=
A2780 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNEm4NlMh|ryP MmqwV2FPT0WU
P12-ICHIKAWA MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\XTWM2OD1yLk[xNlIyKM7:TR?= MXjTRW5ITVJ?
HMV-II NUHaN3N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3pTWM2OD1yLk[0OFY2KM7:TR?= M{j1dHNCVkeHUh?=
HT-144 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvNc|lKSzVyPUCuOlQ3PTdizszN NYXJbFlxW0GQR1XS
LB2518-MEL NWjF[GxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIThU3hKSzVyPUCuO|E3OzJizszN M2HZdXNCVkeHUh?=
NCI-SNU-1 M2j4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LrVWlEPTB;MD63OVQ{OyEQvF2= MXXTRW5ITVJ?
C2BBe1 M4TVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwOEGwNlMh|ryP Ml;IV2FPT0WU
PSN1 NUTndJg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHD[mRKSzVyPUCuPVYyQTZizszN MmDNV2FPT0WU
UACC-257 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwOU[0O|Mh|ryP NWf2dHBIW0GQR1XS
RVH-421 NH\Hb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[wdoJKSzVyPUCuPVcyQCEQvF2= M4HtTnNCVkeHUh?=
GP5d MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwOUizNFgh|ryP M4XDb3NCVkeHUh?=
TYK-nu MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwMEOxO|Ih|ryP NU\xOmpUW0GQR1XS
SK-N-AS M2nJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q3RWlEPTB;MT6wO|k1PyEQvF2= MoHNV2FPT0WU
SW620 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILWVY5KSzVyPUGuNVM2OzRizszN MlnDV2FPT0WU
HuP-T4 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr4TWM2OD1zLkG4N|U6KM7:TR?= MlfQV2FPT0WU
A549 NYnsPW85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PhXmlEPTB;MT6xPVU4PiEQvF2= NF;PdZRUSU6JRWK=
Mewo MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLZTWM2OD1zLkKwNlc3KM7:TR?= NEf6dmJUSU6JRWK=
ONS-76 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwMkKwOFkh|ryP MmDEV2FPT0WU
SK-MEL-1 M4PEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFwMkO0NVkh|ryP MUfTRW5ITVJ?
RCM-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ftdGlEPTB;MT6yOFA1PyEQvF2= MXfTRW5ITVJ?
H-EMC-SS M{nneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjRZpNPUUN3ME2xMlI6PjB6IN88US=> MVnTRW5ITVJ?
NCI-H2291 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XYe2lEPTB;MT6zNlU{PiEQvF2= M2jpWnNCVkeHUh?=
SW1463 MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDvOGk3UUN3ME2xMlM{PzJzIN88US=> NF;2SXlUSU6JRWK=
LS-411N NX7RTHhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3nd2pmUUN3ME2xMlQxPTF5IN88US=> M{XKSXNCVkeHUh?=
BV-173 NGroNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL1XVljUUN3ME2xMlQ1ODF3IN88US=> MVHTRW5ITVJ?
LS-513 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwNEWxPVIh|ryP NEjWTIxUSU6JRWK=
LoVo NIK5dpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwNE[zPVkh|ryP NF7OV4xUSU6JRWK=
HO-1-N-1 M1XDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:0[45KSzVyPUGuOVE3OzRizszN MnHuV2FPT0WU
ML-2 M{nTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwNUK4Olgh|ryP M4W2WXNCVkeHUh?=
NCI-H1437 NGf6[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNUWyO|Uh|ryP MnzkV2FPT0WU
SW1116 NIjmR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHn[ml{UUN3ME2xMlU3Ozl6IN88US=> NWDUXGxIW0GQR1XS
A4-Fuk MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;EUXRKSzVyPUGuOVcxPDVizszN M{\MOXNCVkeHUh?=
HD-MY-Z NX3JdJcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfUbmQ2UUN3ME2xMlU4Ozd4IN88US=> M{SwUnNCVkeHUh?=
SK-MEL-2 M4D6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\jdY5kUUN3ME2xMlU4PDV7IN88US=> M1\1WnNCVkeHUh?=
RT-112 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwNUi5OVIh|ryP NUOxRnV5W0GQR1XS
COLO-829 M4LJU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7STWM2OD1zLk[yNlMzKM7:TR?= NXfBTXhsW0GQR1XS
OVCAR-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u5R2lEPTB;MT63O|Y5PyEQvF2= MnHZV2FPT0WU
NB69 NHfXVpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTzTWM2OD1zLke4OFY6KM7:TR?= M2DQVXNCVkeHUh?=
NCI-H292 M4iwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKwS3FnUUN3ME2xMlg3Pjl7IN88US=> NELoUG1USU6JRWK=
LOXIMVI NWT2U4lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj3bGpSUUN3ME2xMlg6PDJ5IN88US=> NWG4OGc4W0GQR1XS
BPH-1 M3nhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHmTWM2OD1zLki5OVkyKM7:TR?= M2ryR3NCVkeHUh?=
A375 M{nINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDmNGtKSzVyPUGuPFk4OTRizszN NHnDZmpUSU6JRWK=
LCLC-97TM1 Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK1XY1zUUN3ME2xMlkzOjV4IN88US=> Mom2V2FPT0WU
RXF393 NG\GV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HQbGlEPTB;MT65O|g5PyEQvF2= MVLTRW5ITVJ?
HCC70 M3XpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJwMEK0NlYh|ryP Mn\zV2FPT0WU
EM-2 MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36wfWlEPTB;Mj6wO|E6QCEQvF2= MX7TRW5ITVJ?
MZ2-MEL M4jxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fvfGlEPTB;Mj6xNVEzPyEQvF2= MoPRV2FPT0WU
HN NIH2SFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HyUWlEPTB;Mj6xOlI4QCEQvF2= MnvmV2FPT0WU
A2058 NInwZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTqfJFKSzVyPUKuNVkzPzlizszN NUDBUZpUW0GQR1XS
NB7 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnCS4hKSzVyPUKuN|QxQDZizszN MnvIV2FPT0WU
DOK NXvoRpQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HmW2lEPTB;Mj6zOVc4OyEQvF2= NFS5UFJUSU6JRWK=
CAL-27 Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoSxTWM2OD1{LkO5NlM3KM7:TR?= NYHSOXVMW0GQR1XS
BB65-RCC NXnjUZFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnkXHZKSzVyPUKuOFA3PzRizszN M3fadHNCVkeHUh?=
RD NF3KWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7UTWM2OD1{LkS0O|I{KM7:TR?= MlXTV2FPT0WU
KNS-62 NXvibpBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwNUGxOlQh|ryP M4qxdnNCVkeHUh?=
EW-13 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LPdWlEPTB;Mj61OlM{QSEQvF2= M4H1VHNCVkeHUh?=
DB NV3BfIwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwNUi3PFgh|ryP MkS3V2FPT0WU
HCC2218 NXrzRVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD6WXlCUUN3ME2yMlY1Pzd6IN88US=> MV;TRW5ITVJ?
L-363 NGG2SWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTYTo1SUUN3ME2yMlc1OzdizszN M4L5NXNCVkeHUh?=
CHL-1 MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYntN|dCUUN3ME2yMlgxPzh3IN88US=> MoHhV2FPT0WU
BFTC-905 M1rSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO1bIdKSzVyPUKuPFI2OyEQvF2= NI\SbIRUSU6JRWK=
HCE-T NUfnfGhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX3TWM2OD1{LkizNlY1KM7:TR?= NXztXYZGW0GQR1XS
COLO-792 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLXTWM2OD1{Lki0NFI4KM7:TR?= NFHld|NUSU6JRWK=
LB2241-RCC M4e5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX22PGhtUUN3ME2yMlg2QDl|IN88US=> NXToWm9OW0GQR1XS
CAL-39 M4P6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJwOEm5PVkh|ryP NXTJRXk4W0GQR1XS
T-24 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJwOUGxNVIh|ryP M2XDWHNCVkeHUh?=
NCI-H727 M1jkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTJTWM2OD1{LkmxO|k3KM7:TR?= MnLmV2FPT0WU
Ca9-22 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPaTWM2OD1{Lkm3NlU2KM7:TR?= MV\TRW5ITVJ?
MIA-PaCa-2 MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y1fGlEPTB;Mz6wNFc5OSEQvF2= NFT4dFZUSU6JRWK=
HT-1080 NH23dXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX6TWM2OD1|LkCxPVk4KM7:TR?= NW\uNHdiW0GQR1XS
D-423MG MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTNwMEe3OVMh|ryP MmLOV2FPT0WU
LAMA-84 NGXHeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHGbFhKSzVyPUOuNVM2QCEQvF2= NGfSbIVUSU6JRWK=
SW780 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\0TWM2OD1|LkG0NlI6KM7:TR?= M37aN3NCVkeHUh?=
KU-19-19 NEm5fpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHhd2RjUUN3ME2zMlE4ODN2IN88US=> NVrnelVUW0GQR1XS
COLO-741 MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELUenpKSzVyPUOuNVg3PzNizszN NIe2[5hUSU6JRWK=
HSC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHTTWM2OD1|LkKzNVUyKM7:TR?= M4H5SHNCVkeHUh?=
SN12C NV3ROIl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrjbIJpUUN3ME2zMlI1PzBzIN88US=> MYDTRW5ITVJ?
786-0 NEXkWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoraTWM2OD1|LkK3NlQ{KM7:TR?= MnvZV2FPT0WU
GAK MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPQXm5KSzVyPUOuN|I2PjFizszN Mlu5V2FPT0WU
PANC-03-27 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uzPWlEPTB;Mz6zOVA1PSEQvF2= MUjTRW5ITVJ?
CTB-1 NFXifWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrXd3E2UUN3ME2zMlQ4ODR5IN88US=> MnzzV2FPT0WU
A427 M4Hqb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLtbFRZUUN3ME2zMlU6PTV4IN88US=> M4X2d3NCVkeHUh?=
EGI-1 M4Xqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e3U2lEPTB;Mz62NFU5OyEQvF2= NVnW[HJ2W0GQR1XS
U-2-OS NYPEPHZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\tPXpKSzVyPUOuOlczPTZizszN NH7Pc49USU6JRWK=
NCI-SNU-5 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwNke3N{DPxE1? MVrTRW5ITVJ?
SK-LU-1 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTNwNki3PVgh|ryP MWHTRW5ITVJ?
697 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjPZWlKSzVyPUOuOlk3ODNizszN M3ewS3NCVkeHUh?=
HPAF-II NILsdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTNwN{W0PUDPxE1? NY\Mdo1bW0GQR1XS
NCI-H2087 NWDGNoJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDxTWM2OD1|Lki0OlczKM7:TR?= NF3Hfo9USU6JRWK=
SK-MEL-3 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTNwOEWxOVQh|ryP MX;TRW5ITVJ?
CGTH-W-1 NVnlPY82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTrTWM2OD1|Lki1O|I2KM7:TR?= M{[wUXNCVkeHUh?=
8505C MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D1TWlEPTB;Mz65NFA4QCEQvF2= MmjYV2FPT0WU
GAMG NFfEOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRwMEKzO|ch|ryP NIXoVI1USU6JRWK=
SW626 NUHlTmxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTiTGVUUUN3ME20MlA1PDhizszN MX3TRW5ITVJ?
CAL-62 NFvj[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DabmlEPTB;ND6wO|Q{KM7:TR?= MlG0V2FPT0WU
MHH-PREB-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4frRWlEPTB;ND6xNlEyOSEQvF2= NYrSXIgxW0GQR1XS
RPMI-7951 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7icYJ1UUN3ME20MlI2PTh7IN88US=> M4X1bnNCVkeHUh?=
HOP-92 NFLWNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTRwMkW2O{DPxE1? MkLMV2FPT0WU
MDA-MB-231 NHTUTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwMkmyNlMh|ryP MlH3V2FPT0WU
LAN-6 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwM{G2N|ch|ryP MlPlV2FPT0WU
ALL-PO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vlOGlEPTB;ND6zOlE2PiEQvF2= MXzTRW5ITVJ?
HH NV;HfIEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX4R5lKSzVyPUSuOFE2QTdizszN MmnsV2FPT0WU
IGROV-1 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoftTWM2OD12LkS1NVcyKM7:TR?= NHTBcJNUSU6JRWK=
NCI-H358 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIS3Z4tKSzVyPUSuOFU{QDVizszN NXTHUYpkW0GQR1XS
NB5 NUnSXJl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\uTHFKSzVyPUSuOlA{PjlizszN NXjuboROW0GQR1XS
NCI-H747 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjGd41QUUN3ME20MlY5QDB5IN88US=> NHvjWIhUSU6JRWK=
NH-12 M{jsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PvfmlEPTB;ND63NVYzPSEQvF2= MYrTRW5ITVJ?
LB1047-RCC NXfzSo82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDtU2pKSzVyPUSuO|M5OTVizszN MlT5V2FPT0WU
EFO-27 NV\jOo1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[xbnRKSzVyPUSuO|g3PjdizszN MVPTRW5ITVJ?
EPLC-272H MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrlUVVrUUN3ME20Mlk6PjZ7IN88US=> M2TaTnNCVkeHUh?=
CAL-54 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXzWI9KSzVyPUWuNFI3QTVizszN NFqyeodUSU6JRWK=
H4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojOTWM2OD13LkC0NlU2KM7:TR?= MXrTRW5ITVJ?
MOLT-13 M2Czd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTVwME[3O|Yh|ryP NU\neoN7W0GQR1XS
CAL-33 NGPYNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17aWWlEPTB;NT6xNlMyPyEQvF2= M4m1O3NCVkeHUh?=
23132-87 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\sUlNKSzVyPUWuNVY5PzJizszN MlnMV2FPT0WU
UM-UC-3 NX;aS5U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnlTWM2OD13LkG4NFQ4KM7:TR?= NWe5fJRxW0GQR1XS
HuH-7 MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMWmlEPTB;NT6yO|E1PyEQvF2= NWnOS4t7W0GQR1XS
BCPAP M3y3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr2eZlKSzVyPUWuN|I6PjlizszN NILHOW1USU6JRWK=
AsPC-1 M{L4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[ySlA4UUN3ME21MlM3PzZ|IN88US=> NWrJW2pnW0GQR1XS
NCI-H1155 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;6TWM2OD13LkSwNFUyKM7:TR?= NHj3bmJUSU6JRWK=
GT3TKB M{TDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\TTWM2OD13LkS2OVk5KM7:TR?= NWLtOlBWW0GQR1XS
HCC2998 NIjWRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXRclJsUUN3ME21MlQ6OTB7IN88US=> NYrHWIpTW0GQR1XS
NUGC-3 M4\NNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELOSnBKSzVyPUWuOFk{ODJizszN MWHTRW5ITVJ?
Hs-578-T NIPHemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTVwNUO3PVQh|ryP NXS3W45YW0GQR1XS
FADU MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrWOodNUUN3ME21MlU2PzJ4IN88US=> NGfGbFNUSU6JRWK=
NBsusSR NHvaWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjn[ms4UUN3ME21MlU4OTV3IN88US=> M{GyS3NCVkeHUh?=
ME-180 M1rCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrtNXdKSzVyPUWuOVgxQTJizszN NFvzTHJUSU6JRWK=
SW1710 M3Tobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X3VGlEPTB;NT62NVY2PCEQvF2= MkLUV2FPT0WU
HuP-T3 M4Lrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfjTWM2OD13Lk[yNFI6KM7:TR?= NWTsfIlvW0GQR1XS
HOS M4ryOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTVwNkK5NlMh|ryP M2PkZXNCVkeHUh?=
PA-1 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\iU5lQUUN3ME21MlY1OjZ3IN88US=> M4X0[3NCVkeHUh?=
LU-99A NGf5e41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTVwNk[0OVEh|ryP NUfLZmtPW0GQR1XS
RS4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTVwNk[3O|Uh|ryP MlLOV2FPT0WU
TE-8 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLHTWM2OD13Lk[4OVM4KM7:TR?= NGKwb2FUSU6JRWK=
RERF-LC-MS M1TIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LnS2lEPTB;NT62PFgxOyEQvF2= NVHObWhwW0GQR1XS
MEL-JUSO NWexVIh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrufIRKSzVyPUWuO|M4QCEQvF2= M1PwZ3NCVkeHUh?=
SK-MES-1 NFuwVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHteZZ3UUN3ME21Mlg{PTJ6IN88US=> MXHTRW5ITVJ?
D-263MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTVwOEizOVEh|ryP MWXTRW5ITVJ?
NB10 NY\3cYxZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nLc2lEPTB;NT64PVQ3KM7:TR?= M{XrPHNCVkeHUh?=
SK-HEP-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTVwOUO0O|Eh|ryP MWLTRW5ITVJ?
HT-29 NVrGdGs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTVwOUixNVgh|ryP M3;0fnNCVkeHUh?=
KYSE-140 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ITWM2OD14LkCyNVgzKM7:TR?= MX7TRW5ITVJ?
NCI-H1666 NYrtPFVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUXIhKSzVyPU[uNFg1PjFizszN NEnNRlZUSU6JRWK=
NCI-H1304 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi5[nlFUUN3ME22MlE6QTRizszN MkTxV2FPT0WU
RPMI-8866 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LERWlEPTB;Nj6yNVMyOyEQvF2= M{jXTXNCVkeHUh?=
MV-4-11 NXLoZ5VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13rVmlEPTB;Nj6yN|E6QSEQvF2= Mk[2V2FPT0WU
A431 NG\yWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjiPIdEUUN3ME22MlI1Ojl4IN88US=> NWLGZmhqW0GQR1XS
PANC-10-05 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfa[lhCUUN3ME22MlI5OzZ|IN88US=> NYPQNVRCW0GQR1XS
TK10 NWO1eFZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLYTWM2OD14LkOyOlA1KM7:TR?= NGDBfGVUSU6JRWK=
NCI-H1975 MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3OwO2lEPTB;Nj60O|IyPSEQvF2= MW\TRW5ITVJ?
A172 NIrB[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD14LkS5NVc3KM7:TR?= MXTTRW5ITVJ?
D-566MG MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\oeGw6UUN3ME22MlU1OzB|IN88US=> NWLIOZF4W0GQR1XS
NCI-H2122 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\CNoJzUUN3ME22MlYyPTJ6IN88US=> M1r1T3NCVkeHUh?=
COR-L105 NHu4c25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq3SmxoUUN3ME22MlY2Ojd3IN88US=> Ml;KV2FPT0WU
AN3-CA NFvlVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Y[|AxUUN3ME22MlY5PjRzIN88US=> NYLFU2lQW0GQR1XS
Calu-6 NUS1U5ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\EXW9yUUN3ME22Mlc6Pjl6IN88US=> NVT5WlgxW0GQR1XS
HCT-116 NEnLZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTxR2hRUUN3ME22MlgyOjZ2IN88US=> NGfyXlRUSU6JRWK=
MHH-NB-11 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jTd2lEPTB;Nj64OVAxOiEQvF2= Mmn5V2FPT0WU
MFE-280 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7WTWM2OD14Lki1PVg{KM7:TR?= Mn7ZV2FPT0WU
SW1088 Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS1TWM2OD14LkmxPVE{KM7:TR?= M3\acnNCVkeHUh?=
SW48 M1rGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK3fHVyUUN3ME22Mlk1PTFizszN NHe3fWRUSU6JRWK=
HuCCT1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTdwMEGwN|ch|ryP M1rDeHNCVkeHUh?=
ACHN NEm1TVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTITWM2OD15LkCyPVQ{KM7:TR?= M{fScHNCVkeHUh?=
8305C MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TpU2lEPTB;Nz6wPVk6PSEQvF2= M1n3T3NCVkeHUh?=
DoTc2-4510 NXnCVGJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG1XI9EUUN3ME23MlEzOTVizszN Mn3pV2FPT0WU
COR-L23 NVLsPYtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrwTWM2OD15LkK0OFIh|ryP MmjjV2FPT0WU
SK-MEL-30 NGj2eYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf3TWM2OD15LkK1NFg{KM7:TR?= NILMc|lUSU6JRWK=
BE-13 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfXXWxKSzVyPUeuN|M5OzRizszN NGfO[pNUSU6JRWK=
GR-ST MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTdwNECxO|Qh|ryP M1v4e3NCVkeHUh?=
LU-135 NGfjSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\jXGlEPTB;Nz61OVk{QSEQvF2= M4\WXXNCVkeHUh?=
U-266 NIrvNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ufJNRUUN3ME23MlU3Ojh4IN88US=> MoHWV2FPT0WU
NCI-H1355 M4PNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfVem9KSzVyPUeuOVg3OzVizszN NXL4XYJMW0GQR1XS
NB14 NHT5dVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;LTWM2OD15Lk[2OlQzKM7:TR?= NY\yVnIxW0GQR1XS
SCC-25 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTdwN{C5JO69VQ>? NW\hVHFrW0GQR1XS
COLO-678 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX1ToI3UUN3ME23MlcyODd4IN88US=> NWC2T|RLW0GQR1XS
TGBC1TKB M1\pNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf4TWM2OD15Lki5N|k5KM7:TR?= NH;p[mxUSU6JRWK=
IST-MEL1 NWi2NZJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD16LkCwOFA3KM7:TR?= MX7TRW5ITVJ?
ECC10 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvYPWhKSzVyPUiuNFM{QTVizszN NVnZTYhvW0GQR1XS
EW-16 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomwTWM2OD16LkC4OFQ2KM7:TR?= MnvoV2FPT0WU
DOHH-2 M2O0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfmTWM2OD16LkKwNFk2KM7:TR?= NIC1[3ZUSU6JRWK=
NCI-H1581 NGLadGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrzZmluUUN3ME24MlI3OzJ|IN88US=> NFnKdZJUSU6JRWK=
TE-5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fvS2lEPTB;OD60NlQzQSEQvF2= MlTDV2FPT0WU
CAKI-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRThwNUeyNlIh|ryP M1i3cnNCVkeHUh?=
A673 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnUZWFwUUN3ME24MlY{OjB{IN88US=> NInMUW1USU6JRWK=
CAL-12T MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LPeWlEPTB;OD62OVc2OyEQvF2= MmTSV2FPT0WU
DBTRG-05MG NUP6RoV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHuepNKSzVyPUiuO|Q5PTlizszN NUix[2d3W0GQR1XS
SK-N-FI M3\k[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLCNYJKSzVyPUiuPFE{PzlizszN MlruV2FPT0WU
K-562 NUnEWHBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPzUIVKSzVyPUiuPFM6PTdizszN NULhRW9ZW0GQR1XS
SBC-1 NIj1eVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3jPFJKSzVyPUiuPFY3PDVizszN NHfabY5USU6JRWK=
ES4 NEjjToVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXGTXVKSzVyPUiuPFY5QDRizszN MX7TRW5ITVJ?
MS-1 NU\sWHlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRThwOEe1NVch|ryP MYfTRW5ITVJ?
RKO MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULvS5lSUUN3ME24Mlg6ODV5IN88US=> NGHXe5NUSU6JRWK=
NCI-H1693 NFL4[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrVTYt1UUN3ME24MlkzOTdizszN M4\5[HNCVkeHUh?=
SW954 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrLUVVKSzVyPUiuPVY6PzhizszN NWSweWxsW0GQR1XS
SK-UT-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDYcIpKSzVyPUiuPVc3QDNizszN M4\S[3NCVkeHUh?=
T98G MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjpXXhKSzVyPUiuPVk5PDZizszN MUPTRW5ITVJ?
NCI-H2126 NUHqUXgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTlwMEC4NlYh|ryP MoHvV2FPT0WU
TE-12 NWXXNmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz1ZWRKSzVyPUmuNFM{PjdizszN MmXWV2FPT0WU
DK-MG NGDFZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTlwMkGxPVEh|ryP NUW2[Zc5W0GQR1XS
MEG-01 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPoVWZKSzVyPUmuNlQ6OzFizszN NETEe4lUSU6JRWK=
HCC1937 M2nOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwMkmwPVEh|ryP M2OxZXNCVkeHUh?=
MKN45 MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjrWWxuUUN3ME25MlQ2ODZ3IN88US=> MW\TRW5ITVJ?
NCI-H1792 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n4V2lEPTB;OT60OVIyQSEQvF2= Mn7FV2FPT0WU
SW1417 NWnmXlhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTpfGRtUUN3ME25MlU3QDN5IN88US=> M3XKeHNCVkeHUh?=
639-V NEDw[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTlwNkSzPFgh|ryP M{D5W3NCVkeHUh?=
P30-OHK NX3RNXI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv4TWM2OD17Lk[1N|E3KM7:TR?= M2PYNHNCVkeHUh?=
YKG-1 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jQRWlEPTB;OT63OVA{OyEQvF2= MlG2V2FPT0WU
KGN MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrZNFNKSzVyPUmuPFM4QTVizszN M1\EVHNCVkeHUh?=
MSTO-211H NVLYWmU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITMXmpKSzVyPUmuPVU2OjlizszN NVPIZnFMW0GQR1XS
NCI-H1573 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml25TWM2OD1zMD6xOVc1KM7:TR?= MVXTRW5ITVJ?
NCI-H720 NIPMfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV21WphCUUN3ME2xNE4yQTh7IN88US=> M3HOPXNCVkeHUh?=
KARPAS-45 NWjsWYNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZOmlEPTB;MUCuNlc6PSEQvF2= NGDtToZUSU6JRWK=
MDA-MB-175-VII MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\HN|d6UUN3ME2xNE41QCEQvF2= NVHXeZk6W0GQR1XS
SK-NEP-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLRTWM2OD1zMD60PVgyKM7:TR?= NGCxS|NUSU6JRWK=
MKN28 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\WTWM2OD1zMD61NVgh|ryP MnnPV2FPT0WU
KYSE-520 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFyLkWyJO69VQ>? Mn7zV2FPT0WU
KE-37 M4f4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvrTWM2OD1zMD61NlczKM7:TR?= MnvoV2FPT0WU
VA-ES-BJ NYLxW4JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfxTWM2OD1zMD61Olch|ryP NIfldGxUSU6JRWK=
CCRF-CEM MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK0RnZtUUN3ME2xNE42Pjh2IN88US=> MkHaV2FPT0WU
GMS-10 MlzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX6NHVKSzVyPUGwMlYxQTRizszN NHvJR5hUSU6JRWK=
NCI-H1623 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XLcWlEPTB;MUCuOlM4QSEQvF2= NIe4OmpUSU6JRWK=
NEC8 NIPD[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHqTWM2OD1zMD63O|c{KM7:TR?= MoLDV2FPT0WU
MOLT-16 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj6TWM2OD1zMD64NVE{KM7:TR?= MVrTRW5ITVJ?
DJM-1 M1:0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPJN2RKSzVyPUGxMlA{PzlizszN NFLJTVhUSU6JRWK=
U251 NWDLd4hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPNcnROUUN3ME2xNU4xPDJizszN Mnu3V2FPT0WU
SBC-5 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFzLkG0Olch|ryP M3PMOHNCVkeHUh?=
SW756 NInYVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXaTWM2OD1zMT6yNVU1KM7:TR?= NF3OfWdUSU6JRWK=
KS-1 NXn5RXF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPSU2JqUUN3ME2xNU4zPjF7IN88US=> NWHRbZZpW0GQR1XS
SF295 NVnTWYFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL1[ZNKSzVyPUGxMlMyODRizszN Mny2V2FPT0WU
YH-13 NIPTb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCzeIhJUUN3ME2xNU4{OjZ5IN88US=> MkjyV2FPT0WU
SW837 MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XIcmlEPTB;MUGuN|UxPiEQvF2= NHzONGdUSU6JRWK=
KYSE-450 MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXs[mZKSzVyPUGxMlQxPTdizszN MXHTRW5ITVJ?
KYSE-180 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITtTFZKSzVyPUGxMlQ5OiEQvF2= MmTmV2FPT0WU
S-117 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFzLkS4PVYh|ryP M33IO3NCVkeHUh?=
KOSC-2 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrjNZJxUUN3ME2xNU43OjJ{IN88US=> MX\TRW5ITVJ?
KYSE-270 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7qSVFKSzVyPUGxMlg4PDVizszN NFK2d2RUSU6JRWK=
D-336MG MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\hXlVIUUN3ME2xNU46ODd3IN88US=> NIjOSWdUSU6JRWK=
KALS-1 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF{LkCwNVYh|ryP M2nFfnNCVkeHUh?=
LB373-MEL-D MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF{LkC1N|Mh|ryP NHrZbGdUSU6JRWK=
HLE M3qzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDoc2ZQUUN3ME2xNk4xPTh3IN88US=> MWnTRW5ITVJ?
SJSA-1 M1nLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrxZlVKSzVyPUGyMlA4OzVizszN M4XLXnNCVkeHUh?=
SW1990 NV72SpJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[4TWM2OD1zMj6wPVEyKM7:TR?= M3XPPHNCVkeHUh?=
NOS-1 M{XLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF{LkGzOVIh|ryP MmHoV2FPT0WU
GI-ME-N M2roWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF{LkKxOlMh|ryP NU\aVXhOW0GQR1XS
NCI-H1703 NX;TN5o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX3VpZ5UUN3ME2xNk4zPjF4IN88US=> M3T4WHNCVkeHUh?=
ES7 NVT6[XM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHzemlbUUN3ME2xNk4zPzJ2IN88US=> NI\RNVZUSU6JRWK=
KYSE-510 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvCTWM2OD1zMj61NFc6KM7:TR?= NXvSbnloW0GQR1XS
BHY NVjyVWc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF{LkWzNFch|ryP Ml6wV2FPT0WU
TCCSUP M2jHU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{LkW3OVch|ryP MluwV2FPT0WU
HSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3pNo5nUUN3ME2xNk42QTl4IN88US=> NET0WGtUSU6JRWK=
BEN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WySGlEPTB;MUKuOlE1OyEQvF2= MmTSV2FPT0WU
769-P NYnsV2pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF{Lke5NlQh|ryP NFXiU4ZUSU6JRWK=
HT MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm1Vo5wUUN3ME2xNk45OzR4IN88US=> NHfxcZNUSU6JRWK=
LXF-289 NXf4WowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nnc2lEPTB;MUKuPVU{OSEQvF2= NEPuSIlUSU6JRWK=
OVCAR-3 NIPPS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF{Lkm1Olch|ryP M{LUbHNCVkeHUh?=
ATN-1 M1zEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\nXpFKSzVyPUGzMlAyQDRizszN M3vqb3NCVkeHUh?=
8-MG-BA NXXGfVR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\TcolKSzVyPUGzMlA1PTVizszN MlXNV2FPT0WU
SW13 M1SxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHrT4ZKSzVyPUGzMlEyPjVizszN NHvMc4VUSU6JRWK=
NCI-H1092 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXUTWM2OD1zMz6xOlIh|ryP NH:0bYFUSU6JRWK=
OAW-42 M3vnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTF|LkG5N|ch|ryP NHLMN|BUSU6JRWK=
NCI-H2452 NUPCVpVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX61N25DUUN3ME2xN{4zOTd3IN88US=> NY\0TXZXW0GQR1XS
CAPAN-1 NXm3OoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DLOmlEPTB;MUOuOVUyPCEQvF2= NHjt[VFUSU6JRWK=
NCI-H2009 NGfuUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX72SG9mUUN3ME2xN{42QTF7IN88US=> M1K4OHNCVkeHUh?=
SF268 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLsTWM2OD1zMz62N|I3KM7:TR?= Mk\DV2FPT0WU
GCIY MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fQT2lEPTB;MUOuOlkzPyEQvF2= NXzzW|lRW0GQR1XS
OS-RC-2 M4HJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF|Lkm1NFEh|ryP NUPYNGNxW0GQR1XS
GCT NWX6bGU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHxTphNUUN3ME2xN{46Pjl5IN88US=> M2ixdnNCVkeHUh?=
NB17 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rGO2lEPTB;MUSuNFg2KM7:TR?= M3PHfXNCVkeHUh?=
NCI-H2030 M3KxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DmbGlEPTB;MUSuNVQ3PSEQvF2= NVzvfmhuW0GQR1XS
HC-1 M3vjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H0S2lEPTB;MUSuNlA5PyEQvF2= MV\TRW5ITVJ?
QIMR-WIL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW0TWM2OD1zND6zOFEzKM7:TR?= MUnTRW5ITVJ?
Capan-2 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfROHl4UUN3ME2xOE4{PzF2IN88US=> M{j1PHNCVkeHUh?=
BALL-1 NIXOUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;zTWM2OD1zND60OlY2KM7:TR?= NFrmdpVUSU6JRWK=
LS-1034 NUfDdnhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LNTmlEPTB;MUSuOlE2OiEQvF2= NHvCW49USU6JRWK=
U-118-MG MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTF2Lk[zNUDPxE1? NVnnSZZYW0GQR1XS
NCI-H630 M{[5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHSPWY5UUN3ME2xOE43PTZ6IN88US=> NWTGcW1nW0GQR1XS
OVCAR-8 NITUPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH2To5OUUN3ME2xOE44OjBzIN88US=> MV7TRW5ITVJ?
NCI-H2347 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTF2LkiyN{DPxE1? M1zNdHNCVkeHUh?=
BT-549 NYLpUYpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF2LkiyPFQh|ryP NYe0VHIyW0GQR1XS
LB831-BLC M{TyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H0N2lEPTB;MUSuPFk{PCEQvF2= NGrHemVUSU6JRWK=
NCI-H661 NVT1ZnZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L0NWlEPTB;MUSuPVU6KM7:TR?= NEC1SZVUSU6JRWK=
MKN7 M2LFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnnNVVKSzVyPUG1MlAxQTNizszN NVvpTZVYW0GQR1XS
U-87-MG NGXKfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PJVmlEPTB;MUWuNFg6PyEQvF2= NYHSVpNIW0GQR1XS
OVCAR-4 NYjBfnJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPZTWM2OD1zNT6xOFI1KM7:TR?= NVPzVlByW0GQR1XS
OE33 M3PVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD1zNT6xO|EyKM7:TR?= NEnBO4VUSU6JRWK=
EC-GI-10 M4e5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTyWJFsUUN3ME2xOU4zOzV5IN88US=> NV7pe5RQW0GQR1XS
AM-38 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDQWYFuUUN3ME2xOU4zPzF5IN88US=> NV[0d45iW0GQR1XS
NCI-H1563 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X3NWlEPTB;MUWuN|Q6KM7:TR?= NEfCPGdUSU6JRWK=
SCC-4 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTFU5dSUUN3ME2xOU41OTB|IN88US=> MoPzV2FPT0WU
Detroit562 NGCySldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfyTWM2OD1zNT60OVQ4KM7:TR?= NYLkOllxW0GQR1XS
PC-14 NHPxTopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHez[3JKSzVyPUG1MlQ5PjZizszN M4PVT3NCVkeHUh?=
ES3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6ZWlEPTB;MUWuOVM3KM7:TR?= NIr0eJZUSU6JRWK=
OCI-AML2 NXP3NWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;wTWM2OD1zNT63OlE1KM7:TR?= NVjnc251W0GQR1XS
LU-134-A NWjyT2RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL1c|hKSzVyPUG1MlkxOThizszN MlvWV2FPT0WU
SAS MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF3LkmzO|Mh|ryP MYPTRW5ITVJ?
TGBC11TKB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITlXGhKSzVyPUG1Mlk1OTRizszN Ml3PV2FPT0WU
HOP-62 M3iw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHxTWM2OD1zNT65OVk4KM7:TR?= MoO0V2FPT0WU
G-401 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT0PZMzUUN3ME2xOU46PjR7IN88US=> MYDTRW5ITVJ?
NCI-H28 M3HpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF4LkC4OVYh|ryP NULrWnRZW0GQR1XS
A204 NWjhbG9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq1dWdKSzVyPUG2MlIxODZizszN MorwV2FPT0WU
NCI-H1299 M2K3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zEXWlEPTB;MU[uNlI6OSEQvF2= M3\FVnNCVkeHUh?=
VMRC-RCZ NIL3VWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILEN5hKSzVyPUG2MlI2QTJizszN NIflXnRUSU6JRWK=
BxPC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi5WGVlUUN3ME2xOk4zQDV4IN88US=> NUTXbZRbW0GQR1XS
NCI-H2228 M3fId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF4LkWxOVgh|ryP MlP1V2FPT0WU
NCI-H23 NUG5WHh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPLTWM2OD1zNj62NFc5KM7:TR?= M{\QVnNCVkeHUh?=
NKM-1 NUXvSlJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvmTFM4UUN3ME2xO{4xOTh7IN88US=> MnL3V2FPT0WU
KYSE-70 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC1TWM2OD1zNz6yPFkh|ryP M{DZOnNCVkeHUh?=
BB49-HNC NEflc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriUWtKSzVyPUG3MlU3QDZizszN MlHBV2FPT0WU
SCC-15 NU[wfpVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmzcIRKSzVyPUG3Mlg1PzNizszN NHvpcpRUSU6JRWK=
D-247MG Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF5LkmyOFch|ryP MVnTRW5ITVJ?
BB30-HNC NUTZUZNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPOUJJ7UUN3ME2xPE4xOzF6IN88US=> NXq2WJNMW0GQR1XS
CAL-85-1 NFXq[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHrS4ZmUUN3ME2xPE4yQDB7IN88US=> MlrvV2FPT0WU
HT-3 M3H6ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\4TI1rUUN3ME2xPE4{QTd5IN88US=> M2LqdHNCVkeHUh?=
KYSE-410 M1;P[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq0RnVkUUN3ME2xPE41PTd5IN88US=> M4\WTXNCVkeHUh?=
SW982 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS5RmpKSzVyPUG4MlU3PDlizszN MUfTRW5ITVJ?
SW962 NFPSfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojXTWM2OD1zOD61O|AzKM7:TR?= MnfkV2FPT0WU
Ramos-2G6-4C10 M4\4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF6LkW5Nlch|ryP NV;pVXZyW0GQR1XS
OC-314 M4[5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7nTWM2OD1zOD63N|g1KM7:TR?= M1XtWnNCVkeHUh?=
LS-123 M{X1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWntb5BZUUN3ME2xPE44QTBzIN88US=> NWfHNZpJW0GQR1XS
D-502MG M{HJPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF6LkixN|kh|ryP MXXTRW5ITVJ?
RO82-W-1 NG\lcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:xTWM2OD1zOD64Nlg5KM7:TR?= NGfnPWJUSU6JRWK=
HuO9 NHWxTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTtc4FDUUN3ME2xPU4yOzd7IN88US=> NXO1N|FSW0GQR1XS
ETK-1 NHzKXm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfaTWM2OD1zOT6xPFI4KM7:TR?= M4fzWHNCVkeHUh?=
SNU-387 NX3UXVlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17oNWlEPTB;MUmuNVg5QSEQvF2= NVLkbnZLW0GQR1XS
SW1573 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn4PJB2UUN3ME2xPU4yQTZ7IN88US=> Mnz2V2FPT0WU
NTERA-S-cl-D1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDKTWM2OD1zOT6yNFA4KM7:TR?= M2ixUnNCVkeHUh?=
SF126 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF7LkO1NFIh|ryP NEjPOVJUSU6JRWK=
Calu-3 M1fQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHMflNPUUN3ME2xPU41OjN5IN88US=> M{Xkd3NCVkeHUh?=
NCI-H1048 M{PIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWwcpdLUUN3ME2yNE4{OjZ4IN88US=> MXTTRW5ITVJ?
NCI-H226 NYjLOZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\oZ|JKSzVyPUKwMlQ{QTlizszN M2ruZ3NCVkeHUh?=
FTC-133 M2\vcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJyLkS3NFMh|ryP MmfjV2FPT0WU
SF539 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Tz[WlEPTB;MkCuOVE4OiEQvF2= NUPmc5Y{W0GQR1XS
TE-6 NImwN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJyLkiwOlch|ryP M4TWcnNCVkeHUh?=
UMC-11 NYrhWJBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzQNWJ5UUN3ME2yNE46OTZ2IN88US=> MV3TRW5ITVJ?
Becker MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPXdWtQUUN3ME2yNU4yOTF6IN88US=> NGjONoRUSU6JRWK=
KP-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrweGdKSzVyPUKxMlEyQTZizszN MXvTRW5ITVJ?
ChaGo-K-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe4dHEyUUN3ME2yNU4{PjJ5IN88US=> NY[wflV2W0GQR1XS
CFPAC-1 M4TrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTW[5pJUUN3ME2yNU4{QDV6IN88US=> NXj2PGxUW0GQR1XS
A498 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnXTWM2OD1{MT61N|EzKM7:TR?= M{OwXnNCVkeHUh?=
NCI-H1755 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nnOWlEPTB;MkGuOlc1OSEQvF2= NYT2SnFYW0GQR1XS
TI-73 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInCc4pKSzVyPUKyMlMzQCEQvF2= NXHkR5Z[W0GQR1XS
NCI-H441 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:2TWM2OD1{Mj61Olg6KM7:TR?= M1HYUnNCVkeHUh?=
CaR-1 NX3ubFFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTrO49HUUN3ME2yN{4xOjF|IN88US=> NXLZVmcyW0GQR1XS
HCC1806 NVXLT5E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\6ZmlEPTB;MkOuNFU5OyEQvF2= MkP0V2FPT0WU
SNU-449 NGq5XodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jzTGlEPTB;MkOuN|I6KM7:TR?= MYLTRW5ITVJ?
EKVX MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7tZnNKSzVyPUKzMlM6ODlizszN MlXKV2FPT0WU
DMS-114 M4\1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTlS|NqUUN3ME2yN{42PzZ3IN88US=> MVvTRW5ITVJ?
A704 NEKy[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vKU2lEPTB;MkOuOlExOyEQvF2= M1jhdXNCVkeHUh?=
LC-2-ad M3rqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJ|Lk[xOFch|ryP M362WnNCVkeHUh?=
VM-CUB-1 M134bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofUTWM2OD1{Mz63N|QyKM7:TR?= NHThe3pUSU6JRWK=
PC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLjUoQ3UUN3ME2yOE4xPTJ4IN88US=> M1PxO3NCVkeHUh?=
HEL NX7oOYdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLQSItKSzVyPUK0MlA5PjVizszN M2X2WnNCVkeHUh?=
ABC-1 MoDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELyOo1KSzVyPUK0MlI4OjlizszN NFzVNGxUSU6JRWK=
COLO-680N MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHLb4FKSzVyPUK0MlQ4PjRizszN M4LrdXNCVkeHUh?=
MZ1-PC M370dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX30Z4lQUUN3ME2yOE43QDdizszN NFjoOGxUSU6JRWK=
NCI-H69 NFfxd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L1XGlEPTB;MkSuO|M2PCEQvF2= NHXpN4dUSU6JRWK=
TE-1 M1;6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGzPIdKSzVyPUK1MlA1QTlizszN M{naO3NCVkeHUh?=
EW-3 M3fTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPRVGFDUUN3ME2yOU4yOTNizszN NIX4R3pUSU6JRWK=
PANC-08-13 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32xXWlEPTB;MkWuPFExOyEQvF2= MkjCV2FPT0WU
NMC-G1 M{K2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH5U5NKSzVyPUK2MlAxQDhizszN MkHYV2FPT0WU
BT-20 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ4LkS1OFMh|ryP MU\TRW5ITVJ?
TGBC24TKB NYCwUJJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e3VGlEPTB;Mk[uO|M{OSEQvF2= MXzTRW5ITVJ?
TE-11 NH7qSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ4Lkm4PVUh|ryP MYXTRW5ITVJ?
ESS-1 NUPISohzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vxS2lEPTB;MkeuN|IyPiEQvF2= M3;mOnNCVkeHUh?=
JVM-3 NWT2b3I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf1TWM2OD1{Nz62OFc2KM7:TR?= M4PXUXNCVkeHUh?=
C3A M4jIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LoNGlEPTB;MkeuPFQ6PiEQvF2= M2PIVXNCVkeHUh?=
MDA-MB-157 M2XDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr6[pE6UUN3ME2yO{45PzV|IN88US=> NGnFPZpUSU6JRWK=
KLE NHr5WlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTObINKSzVyPUK4MlExPThizszN NVTjO3l4W0GQR1XS
ES1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTmTWM2OD1{OD6xPFM5KM7:TR?= M2Lj[3NCVkeHUh?=
CAL-120 NXjLc29kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ6LkO5PVkh|ryP M1rLO3NCVkeHUh?=
NCI-N87 NULwS5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\LeVhDUUN3ME2yPE42OTB3IN88US=> NWHje3J2W0GQR1XS
RPMI-8226 NXLDOo5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnvSGxxUUN3ME2yPU4yQDR|IN88US=> MVLTRW5ITVJ?
COR-L88 M{Gw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[3O5FuUUN3ME2yPU4zPDF7IN88US=> NVTpUmtmW0GQR1XS
UACC-893 NV7qZolQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ7LkOxN|ch|ryP M1fTfHNCVkeHUh?=
C8166 M3XzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S1W2lEPTB;MkmuPVk6PiEQvF2= MorIV2FPT0WU
J82 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f5bWlEPTB;M{CuPFE1PyEQvF2= MW\TRW5ITVJ?
PFSK-1 NXnseHZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG2OXBzUUN3ME2zNU4xPjV7IN88US=> NF\qXXFUSU6JRWK=
COLO-684 NXTObI1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rHcmlEPTB;M{GuOFM4PCEQvF2= MUTTRW5ITVJ?
CAL-72 NXvUTGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK3ToZ{UUN3ME2zNU42PzJ7IN88US=> MlTtV2FPT0WU
SNB75 NF3ycXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TzUmlEPTB;M{GuPFk4KM7:TR?= M1LrUnNCVkeHUh?=
MDA-MB-415 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnjWZdKSzVyPUOxMlk4PjJizszN MX7TRW5ITVJ?
SiHa MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPkTWM2OD1|Mj60O|EyKM7:TR?= MVrTRW5ITVJ?
NCI-H1648 NVjFXFlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTN{LkmzOFUh|ryP M4fNVnNCVkeHUh?=
EFO-21 NUm3WVRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTN|LkCwOUDPxE1? MkmxV2FPT0WU
HCC38 M{P4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7uPYZMUUN3ME2zN{4{QDRzIN88US=> M1OxTXNCVkeHUh?=
IA-LM NUfncld6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTN|Lke4PFkh|ryP MVnTRW5ITVJ?
CTV-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPmNZR7UUN3ME2zN{46Pzh4IN88US=> M2fmdnNCVkeHUh?=
NCI-H446 NX3vRmtbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Qb|ZXUUN3ME2zOE4zPjh7IN88US=> MkjZV2FPT0WU
IST-SL1 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT1e3JkUUN3ME2zOE44PDB6IN88US=> MUXTRW5ITVJ?
EW-22 NYXVNnFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\rdmlEPTB;M{SuO|c2QSEQvF2= MoHxV2FPT0WU
JEG-3 NVHDeXpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonRTWM2OD1|Nj6xO|Y3KM7:TR?= NXXhflBIW0GQR1XS
LU-65 NXvibGhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG5TWM2OD1|Nj6yPVg2KM7:TR?= NXjiXng{W0GQR1XS
NCI-H596 M1yyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n4cGlEPTB;M{[uPVU6OSEQvF2= MUPTRW5ITVJ?
KNS-81-FD NXjkd|A6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ld4tKSzVyPUO3MlE1PSEQvF2= Ml35V2FPT0WU
NCI-H1793 MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN5LkewPFYh|ryP Moj0V2FPT0WU
NCI-H460 NGH6bm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljOTWM2OD1|OD6wPFc{KM7:TR?= NVjZUWZlW0GQR1XS
MPP-89 M2HIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vTUGlEPTB;M{muOVg5PiEQvF2= NHfVSZVUSU6JRWK=
D-542MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjOTWM2OD1|OT64OFM3KM7:TR?= M4D0VXNCVkeHUh?=
JAR NEDofnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPtTWM2OD12MD60O|A2KM7:TR?= MWLTRW5ITVJ?
NCI-H209 M4DYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH25RXFKSzVyPUSwMlY4PyEQvF2= NHrZSWlUSU6JRWK=
G-402 NF7x[GRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu2TWM2OD12MT6zPVk{KM7:TR?= MWDTRW5ITVJ?
IST-MES1 NITURVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnuTWM2OD12Mj6xPVM2KM7:TR?= M4LwWXNCVkeHUh?=
Daoy MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj5c5FRUUN3ME20Nk42PDdzIN88US=> NFOwd5NUSU6JRWK=
EW-11 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHDRZg2UUN3ME20N{4yOjFzIN88US=> Mo\sV2FPT0WU
Saos-2 NYjEVYFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTR|LkG1N|ch|ryP M1vlU3NCVkeHUh?=
no-10 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnjTWM2OD12Mz6xO|AzKM7:TR?= MWHTRW5ITVJ?
HCC1395 NEHsU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izfmlEPTB;NEOuOFY1PCEQvF2= MlnsV2FPT0WU
HCE-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fhW2lEPTB;NEOuO|Y3PCEQvF2= NHv6OWFUSU6JRWK=
EW-1 NGHGPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\OTmlEPTB;NEOuPFA1QSEQvF2= NHX0NlJUSU6JRWK=
OCUB-M NVnDZ|c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\STWM2OD12ND6zOlM5KM7:TR?= MojyV2FPT0WU
IGR-1 NEXz[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR2LkSxNVUh|ryP NGn6blhUSU6JRWK=
NCI-H1838 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjDWZFKSzVyPUS0MlQ{PDlizszN Mlm1V2FPT0WU
NCI-H2405 M{nUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfPTWM2OD12ND61N|Qh|ryP MnTnV2FPT0WU
GB-1 NFnNTGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P6T2lEPTB;NESuO|Q3OyEQvF2= MYLTRW5ITVJ?
MG-63 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTR4LkC2PVYh|ryP NH[wXZBUSU6JRWK=
KP-N-YN MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTR4LkS2O|kh|ryP M1vQcXNCVkeHUh?=
no-11 MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\zSmlEPTB;NEeuNFI1PCEQvF2= Mnq3V2FPT0WU
SW948 NUDZWYxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPnXZk6UUN3ME20O{4{Ozd5IN88US=> MYHTRW5ITVJ?
CAMA-1 NWL2W2E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInienJKSzVyPUS3MlM1OzhizszN NWXtUWdCW0GQR1XS
HCC1187 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH23fGRKSzVyPUS3MlUyKM7:TR?= MWjTRW5ITVJ?
D-392MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LP[GlEPTB;NEeuOlUyPiEQvF2= NVvrZodoW0GQR1XS
647-V MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zKb2lEPTB;NEmuN|QyPCEQvF2= MYjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK1/2 / ERK1/2 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK1/2 in sympathetic neurons. Immunoblots were performed with whole cell extracts from sympathetic neurons maintained in the presence of NGF and left untreated or treated with PD184352 at 0.1, 1, 2 or 10 μM for 16 hours. Antibodies to detect total ERK1/2 and phospho-ERK1/2 were used. 

p-ERK5 / ERK5 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK5 in sympathetic neurons.

21762482
Growth inhibition assay
Cell viability; 

PubMed: 29989268     


Relative viability of DU145CR cells treated with PD184352 was significantly less than that of DU145 cells in WST assay. 

29989268
In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

- Collapse

MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

- Collapse
  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

- Collapse
  • Animal Models: PTC cells in athymic mice
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A
Smiles C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Related MEK Products

Tags: buy PD184352 (CI-1040) | PD184352 (CI-1040) supplier | purchase PD184352 (CI-1040) | PD184352 (CI-1040) cost | PD184352 (CI-1040) manufacturer | order PD184352 (CI-1040) | PD184352 (CI-1040) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID