PD184352 (CI-1040)

Catalog No.S1020

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

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In DMSO USD 140 In stock
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Cited by 78 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEKyO|Yh|ryP MkixV2FPT0WU
CHP-212 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLyTWM2OD1yLkCyPFg2KM7:TR?= NIfye5ZUSU6JRWK=
EoL-1-cell NF3FOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfWTWM2OD1yLkC0NVUzKM7:TR?= NGPYb3BUSU6JRWK=
DU-4475 M2OyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH3fYN3UUN3ME2wMlA4PTl7IN88US=> NHjJcItUSU6JRWK=
MMAC-SF MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7FfpNsUUN3ME2wMlExQTd2IN88US=> M2G5cHNCVkeHUh?=
AGS M2PFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom1TWM2OD1yLkGxO|E{KM7:TR?= NHqxR2RUSU6JRWK=
M14 M4XuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHrb3VrUUN3ME2wMlE2PDZ6IN88US=> NYjRUVRwW0GQR1XS
CP50-MEL-B NGexcnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMUeyOVQh|ryP NFzwV3ZUSU6JRWK=
C32 M3Xnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL3VHBKSzVyPUCuNVkxPzJizszN Ml33V2FPT0WU
KMOE-2 M3HZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX3XXZtUUN3ME2wMlE6Pzl3IN88US=> Mk\XV2FPT0WU
A101D MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\hZlFKSzVyPUCuNlE1KM7:TR?= NGi5eFRUSU6JRWK=
KM12 NFnidoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf0TWM2OD1yLkK0NFU4KM7:TR?= NWPYXnAyW0GQR1XS
HSC-4 M1LjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfEdIxVUUN3ME2wMlI1Ozl3IN88US=> NYDIOXVZW0GQR1XS
NOMO-1 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvLTWM2OD1yLkK1O|QzKM7:TR?= NE\EXYFUSU6JRWK=
MZ7-mel NFHvZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LxO2lEPTB;MD6yOlM1KM7:TR?= MkjIV2FPT0WU
ACN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XKPWlEPTB;MD6yOlc{PyEQvF2= NIWzcJBUSU6JRWK=
MEL-HO M4TBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr4VI5JUUN3ME2wMlI4PjV{IN88US=> NHfyZVFUSU6JRWK=
BHT-101 NHPQU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHuTWM2OD1yLkK4OlA3KM7:TR?= MWPTRW5ITVJ?
SK-MEL-28 NXLqbVZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLzSWdCUUN3ME2wMlMxPDB7IN88US=> Ml7GV2FPT0WU
KG-1 NHm5eYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrOTWM2OD1yLkOwOlY5KM7:TR?= NV:zNG1LW0GQR1XS
COLO-679 NHPyPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwM{K3NkDPxE1? MYTTRW5ITVJ?
SK-MEL-24 NID0NodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO5e|RyUUN3ME2wMlMzQDF|IN88US=> MWLTRW5ITVJ?
G-361 NFHUOpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwM{[3PVUh|ryP NHnNVIpUSU6JRWK=
KY821 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfqdVZKSzVyPUCuN|c6OSEQvF2= M1j2TXNCVkeHUh?=
KASUMI-1 NFjTb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwM{m5JO69VQ>? NFLy[I9USU6JRWK=
HL-60 M1XzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLKTWM2OD1yLkSxNVA4KM7:TR?= NUjQc4h5W0GQR1XS
K5 M3LDVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwNEOxNVch|ryP MYLTRW5ITVJ?
KU812 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XqNmlEPTB;MD60OVI6QSEQvF2= NF73OWtUSU6JRWK=
SH-4 M{DrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13QfGlEPTB;MD60OlI2PiEQvF2= NFTkVnZUSU6JRWK=
HTC-C3 NVThfpl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vue2lEPTB;MD60OlU{OSEQvF2= MXvTRW5ITVJ?
CP66-MEL MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HjfGlEPTB;MD60PFgxQSEQvF2= NEPFT4hUSU6JRWK=
WM-115 M1XV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzPbJR[UUN3ME2wMlQ6OjV5IN88US=> NXHuXGZjW0GQR1XS
A2780 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn6RYlFUUN3ME2wMlQ6QDJ|IN88US=> MYTTRW5ITVJ?
P12-ICHIKAWA MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;De4FKSzVyPUCuOlEzOjFizszN MojpV2FPT0WU
HMV-II M2K1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjFWWV[UUN3ME2wMlY1PDZ3IN88US=> MYjTRW5ITVJ?
HT-144 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwNkS2OVch|ryP NV;ZWZNqW0GQR1XS
LB2518-MEL M3fM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\1TWM2OD1yLkexOlMzKM7:TR?= NWPvRYE1W0GQR1XS
NCI-SNU-1 NWXNbYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwN{W0N|Mh|ryP NVvlTZB4W0GQR1XS
C2BBe1 M1u1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\qc2tKSzVyPUCuPFExOjNizszN NYHCXHBLW0GQR1XS
PSN1 NFjXNnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwOU[xPVYh|ryP MVfTRW5ITVJ?
UACC-257 NV7NVI13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwOU[0O|Mh|ryP NGHI[YFUSU6JRWK=
RVH-421 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qxdGlEPTB;MD65O|E5KM7:TR?= M2fn[3NCVkeHUh?=
GP5d MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwOUizNFgh|ryP NFHKPI1USU6JRWK=
TYK-nu MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT4UW9ZUUN3ME2xMlA{OTd{IN88US=> M{DKZXNCVkeHUh?=
SK-N-AS NH3wUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwMEe5OFch|ryP MljBV2FPT0WU
SW620 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnje4MxUUN3ME2xMlE{PTN2IN88US=> NVL0WGFkW0GQR1XS
HuP-T4 NVvreHRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojhTWM2OD1zLkG4N|U6KM7:TR?= NVq1OVFvW0GQR1XS
A549 NIjNenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTITWM2OD1zLkG5OVc3KM7:TR?= NGHTTIdUSU6JRWK=
Mewo NEC1RZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknrTWM2OD1zLkKwNlc3KM7:TR?= MkT4V2FPT0WU
ONS-76 NHLIVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\Xd2E1UUN3ME2xMlIzODR7IN88US=> MYjTRW5ITVJ?
SK-MEL-1 M1fKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPld2pHUUN3ME2xMlI{PDF7IN88US=> MkTsV2FPT0WU
RCM-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPJNWw3UUN3ME2xMlI1ODR5IN88US=> MofxV2FPT0WU
H-EMC-SS NGjZS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFwMkm2NFgh|ryP MkHBV2FPT0WU
NCI-H2291 NHW0XndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7sNZZsUUN3ME2xMlMzPTN4IN88US=> NFruZ5NUSU6JRWK=
SW1463 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTFOolKSzVyPUGuN|M4OjFizszN MV\TRW5ITVJ?
LS-411N NIfzVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HJS2lEPTB;MT60NFUyPyEQvF2= NUf4Z4tCW0GQR1XS
BV-173 M1T3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULDVYNmUUN3ME2xMlQ1ODF3IN88US=> MVHTRW5ITVJ?
LS-513 NUGwRlNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwNEWxPVIh|ryP NUDYcGJHW0GQR1XS
LoVo NIWzVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPLU2JKSzVyPUGuOFY{QTlizszN MYXTRW5ITVJ?
HO-1-N-1 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHtTWM2OD1zLkWxOlM1KM7:TR?= MXfTRW5ITVJ?
ML-2 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LKSWlEPTB;MT61Nlg3QCEQvF2= NX;EU|F5W0GQR1XS
NCI-H1437 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\3TINDUUN3ME2xMlU2Ojd3IN88US=> NG\0NmJUSU6JRWK=
SW1116 NVjVSnBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3PTWM2OD1zLkW2N|k5KM7:TR?= MYTTRW5ITVJ?
A4-Fuk M{TN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnG3TWM2OD1zLkW3NFQ2KM7:TR?= M2q0d3NCVkeHUh?=
HD-MY-Z Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zobmlEPTB;MT61O|M4PiEQvF2= NVznVXZZW0GQR1XS
SK-MEL-2 NFnNfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTFwNUe0OVkh|ryP MWDTRW5ITVJ?
RT-112 NYPGVmZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwNUi5OVIh|ryP MlPkV2FPT0WU
COLO-829 NYT5SWMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwNkKyN|Ih|ryP NV;sS5g4W0GQR1XS
OVCAR-5 NWPWbnVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTmS3dRUUN3ME2xMlc4Pjh5IN88US=> MlrNV2FPT0WU
NB69 M1;XRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T3VmlEPTB;MT63PFQ3QSEQvF2= MkSwV2FPT0WU
NCI-H292 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwOE[2PVkh|ryP M{f5[HNCVkeHUh?=
LOXIMVI NWfxZ4p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwOEm0Nlch|ryP M37lcXNCVkeHUh?=
BPH-1 NHPmcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr3TWM2OD1zLki5OVkyKM7:TR?= M3XoNHNCVkeHUh?=
A375 M13CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELpUnlKSzVyPUGuPFk4OTRizszN M371UnNCVkeHUh?=
LCLC-97TM1 M4G4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXh[HlKSzVyPUGuPVIzPTZizszN MXLTRW5ITVJ?
RXF393 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSyTWM2OD1zLkm3PFg4KM7:TR?= M3LBUnNCVkeHUh?=
HCC70 NXi0V3I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPnZZZKSzVyPUKuNFI1OjZizszN MmTYV2FPT0WU
EM-2 NHXsfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIex[GJKSzVyPUKuNFcyQThizszN Mk\uV2FPT0WU
MZ2-MEL M1fsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LRZmlEPTB;Mj6xNVEzPyEQvF2= NVm4Wo1xW0GQR1XS
HN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD5TXRWUUN3ME2yMlE3Ojd6IN88US=> NXvTT2hUW0GQR1XS
A2058 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HWWGlEPTB;Mj6xPVI4QSEQvF2= MVfTRW5ITVJ?
NB7 NGC0SodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJwM{SwPFYh|ryP MoPOV2FPT0WU
DOK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13lNmlEPTB;Mj6zOVc4OyEQvF2= MmiyV2FPT0WU
CAL-27 NWq2SoR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJwM{myN|Yh|ryP NWDvPYQzW0GQR1XS
BB65-RCC M1;Ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TMR2lEPTB;Mj60NFY4PCEQvF2= MnjvV2FPT0WU
RD MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLKV2kzUUN3ME2yMlQ1PzJ|IN88US=> MXrTRW5ITVJ?
KNS-62 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rUdmlEPTB;Mj61NVE3PCEQvF2= M17qOXNCVkeHUh?=
EW-13 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\5TWM2OD1{LkW2N|M6KM7:TR?= MXHTRW5ITVJ?
DB M33qcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PaNmlEPTB;Mj61PFc5QCEQvF2= M1zjU3NCVkeHUh?=
HCC2218 NYDnS3drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT5TWM2OD1{Lk[0O|c5KM7:TR?= NX;2bIdOW0GQR1XS
L-363 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwN{SzO{DPxE1? NV[wUpNxW0GQR1XS
CHL-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLWS4x{UUN3ME2yMlgxPzh3IN88US=> NFXmbIRUSU6JRWK=
BFTC-905 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrkfo1KSzVyPUKuPFI2OyEQvF2= M3jDOXNCVkeHUh?=
HCE-T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwOEOyOlQh|ryP MmnJV2FPT0WU
COLO-792 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwOESwNlch|ryP MX7TRW5ITVJ?
LB2241-RCC NHj5ZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT6TWM2OD1{Lki1PFk{KM7:TR?= NXi0c5VwW0GQR1XS
CAL-39 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELtSlFKSzVyPUKuPFk6QTlizszN MnXmV2FPT0WU
T-24 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwOUGxNVIh|ryP M3zRc3NCVkeHUh?=
NCI-H727 M3\MWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;zTWM2OD1{LkmxO|k3KM7:TR?= NYC3VmplW0GQR1XS
Ca9-22 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSzTohKSzVyPUKuPVczPTVizszN MWXTRW5ITVJ?
MIA-PaCa-2 NV\k[I1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm0T3JKSzVyPUOuNFA4QDFizszN MmPhV2FPT0WU
HT-1080 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfXbmVKSzVyPUOuNFE6QTdizszN NFnKPFVUSU6JRWK=
D-423MG NGe1SoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInkUZFKSzVyPUOuNFc4PTNizszN MlLKV2FPT0WU
LAMA-84 NXGwd49LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rzemlEPTB;Mz6xN|U5KM7:TR?= M1rtZ3NCVkeHUh?=
SW780 M1rCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO1PHNKSzVyPUOuNVQzOjlizszN NYf1c3BjW0GQR1XS
KU-19-19 NIjmXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNwMUewN|Qh|ryP MkfhV2FPT0WU
COLO-741 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K5PWlEPTB;Mz6xPFY4OyEQvF2= MUnTRW5ITVJ?
HSC-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXyTWM2OD1|LkKzNVUyKM7:TR?= MWPTRW5ITVJ?
SN12C NEKzXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrz[2Z[UUN3ME2zMlI1PzBzIN88US=> M3;FXXNCVkeHUh?=
786-0 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNwMkeyOFMh|ryP MVPTRW5ITVJ?
GAK M1TPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTNwM{K1OlEh|ryP NHTWcodUSU6JRWK=
PANC-03-27 M2j5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XpcmlEPTB;Mz6zOVA1PSEQvF2= NXLGTWV6W0GQR1XS
CTB-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\0dGlEPTB;Mz60O|A1PyEQvF2= MUjTRW5ITVJ?
A427 Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf1dFlbUUN3ME2zMlU6PTV4IN88US=> NWW0TnVDW0GQR1XS
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YKG-1 NEjZWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm0OXdGUUN3ME25Mlc2ODN|IN88US=> NHTFOXJUSU6JRWK=
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NCI-H720 NH7nWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TqR2lEPTB;MUCuNVk5QSEQvF2= MkjyV2FPT0WU
KARPAS-45 M{Xje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXQcJVKSzVyPUGwMlI4QTVizszN NEj4R3dUSU6JRWK=
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MKN28 NVWxZYZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrOTWM2OD1zMD61NVgh|ryP MnvoV2FPT0WU
KYSE-520 NW\IPHlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPCTWM2OD1zMD61NkDPxE1? M1uyV3NCVkeHUh?=
KE-37 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFyLkWyO|Ih|ryP M1zkSnNCVkeHUh?=
VA-ES-BJ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHlWGFUUUN3ME2xNE42PjdizszN M{\BW3NCVkeHUh?=
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GMS-10 M3:ySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnqRWx[UUN3ME2xNE43ODl2IN88US=> M{S1cXNCVkeHUh?=
NCI-H1623 NWjMWnRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;SdHh{UUN3ME2xNE43Ozd7IN88US=> NYixZ5M5W0GQR1XS
NEC8 M1XIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WwUGlEPTB;MUCuO|c4OyEQvF2= MX3TRW5ITVJ?
MOLT-16 M4SyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTFyLkixNVMh|ryP MYDTRW5ITVJ?
DJM-1 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofjTWM2OD1zMT6wN|c6KM7:TR?= MoLEV2FPT0WU
U251 M4HMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGKz[olKSzVyPUGxMlA1OiEQvF2= MUDTRW5ITVJ?
SBC-5 NUHuW5gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXJW45xUUN3ME2xNU4yPDZ5IN88US=> NYC0XohJW0GQR1XS
SW756 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof4TWM2OD1zMT6yNVU1KM7:TR?= NGjBXY9USU6JRWK=
KS-1 NH7lbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f5bGlEPTB;MUGuNlYyQSEQvF2= NXPRbosyW0GQR1XS
SF295 NX7yN3JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f6SmlEPTB;MUGuN|ExPCEQvF2= MlHVV2FPT0WU
YH-13 NYru[3dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFzLkOyOlch|ryP NXLSfVlCW0GQR1XS
SW837 NUj3NY1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\QTGlEPTB;MUGuN|UxPiEQvF2= M{naV3NCVkeHUh?=
KYSE-450 M2G0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFzLkSwOVch|ryP MkKxV2FPT0WU
KYSE-180 NIGzbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPUO4RYUUN3ME2xNU41QDJizszN MoLmV2FPT0WU
S-117 M1HZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnjdVU4UUN3ME2xNU41QDl4IN88US=> NIW5NphUSU6JRWK=
KOSC-2 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFzLk[yNlIh|ryP Mlf5V2FPT0WU
KYSE-270 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnwSm4yUUN3ME2xNU45PzR3IN88US=> NUD2boQ6W0GQR1XS
D-336MG NEj0e4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLtTWM2OD1zMT65NFc2KM7:TR?= MlTaV2FPT0WU
KALS-1 NHezXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorMTWM2OD1zMj6wNFE3KM7:TR?= NEH0enpUSU6JRWK=
LB373-MEL-D NUPZSYN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TB[WlEPTB;MUKuNFU{OyEQvF2= M13PeHNCVkeHUh?=
HLE NHznfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDHTWM2OD1zMj6wOVg2KM7:TR?= NFjPSm1USU6JRWK=
SJSA-1 M{jQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4TWlEPTB;MUKuNFc{PSEQvF2= M4fZXHNCVkeHUh?=
SW1990 M3\6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPJXHM4UUN3ME2xNk4xQTFzIN88US=> MV\TRW5ITVJ?
NOS-1 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3pUYdKSzVyPUGyMlE{PTJizszN NXv2VlRGW0GQR1XS
GI-ME-N M1nqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrt[XBbUUN3ME2xNk4zOTZ|IN88US=> NHrHV2JUSU6JRWK=
NCI-H1703 NHLCNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;hTWM2OD1zMj6yOlE3KM7:TR?= Mn7xV2FPT0WU
ES7 NXXsfnVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHHUGpIUUN3ME2xNk4zPzJ2IN88US=> MmeyV2FPT0WU
KYSE-510 NWjiUFZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\NZW1lUUN3ME2xNk42ODd7IN88US=> NVG3[HRnW0GQR1XS
BHY Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HwNmlEPTB;MUKuOVMxPyEQvF2= MVfTRW5ITVJ?
TCCSUP NEnmb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj6W4ZKSzVyPUGyMlU4PTdizszN MXnTRW5ITVJ?
HSC-2 NUezTnRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NViyOpN[UUN3ME2xNk42QTl4IN88US=> NGDubFdUSU6JRWK=
BEN Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF{Lk[xOFMh|ryP MXTTRW5ITVJ?
769-P NIm3XFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fGeGlEPTB;MUKuO|kzPCEQvF2= MoiwV2FPT0WU
HT MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDhTWM2OD1zMj64N|Q3KM7:TR?= NVjSeoE1W0GQR1XS
LXF-289 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfNO2ZTUUN3ME2xNk46PTNzIN88US=> MXfTRW5ITVJ?
OVCAR-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jTR2lEPTB;MUKuPVU3PyEQvF2= MmrRV2FPT0WU
ATN-1 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofrTWM2OD1zMz6wNVg1KM7:TR?= NEnmNVlUSU6JRWK=
8-MG-BA NGWxd2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn34TWM2OD1zMz6wOFU2KM7:TR?= MnLlV2FPT0WU
SW13 NUjVepFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF|LkGxOlUh|ryP NIr5cItUSU6JRWK=
NCI-H1092 NUK5em9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\FTWM2OD1zMz6xOlIh|ryP MlLPV2FPT0WU
OAW-42 M{TLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPa[5FKSzVyPUGzMlE6OzdizszN NELle4JUSU6JRWK=
NCI-H2452 NV3TUlBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLHSY1KSzVyPUGzMlIyPzVizszN M1nDRXNCVkeHUh?=
CAPAN-1 M3To[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;3bWlEPTB;MUOuOVUyPCEQvF2= NXzVVHdPW0GQR1XS
NCI-H2009 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF|LkW5NVkh|ryP MlrEV2FPT0WU
SF268 M1v0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDt[YFFUUN3ME2xN{43OzJ4IN88US=> MYHTRW5ITVJ?
GCIY M4\mfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLtTWM2OD1zMz62PVI4KM7:TR?= MXTTRW5ITVJ?
OS-RC-2 NVvtTGxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTZTWM2OD1zMz65OVAyKM7:TR?= MmfqV2FPT0WU
GCT NEP3SYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXKc4pGUUN3ME2xN{46Pjl5IN88US=> M{fIenNCVkeHUh?=
NB17 NWHPe3pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37B[WlEPTB;MUSuNFg2KM7:TR?= NYftTWp5W0GQR1XS
NCI-H2030 M2O2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHOTWM2OD1zND6xOFY2KM7:TR?= NVfMUpFzW0GQR1XS
HC-1 NVPicGV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjldWE6UUN3ME2xOE4zODh5IN88US=> M{n1ZXNCVkeHUh?=
QIMR-WIL MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rDbGlEPTB;MUSuN|QyOiEQvF2= MnjmV2FPT0WU
Capan-2 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOy[JBKSzVyPUG0MlM4OTRizszN NIPXOlhUSU6JRWK=
BALL-1 NV;ZS3NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvRZZFKSzVyPUG0MlQ3PjVizszN Mm\rV2FPT0WU
LS-1034 NUKzUGZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jKc2lEPTB;MUSuOlE2OiEQvF2= NX31WJlMW0GQR1XS
U-118-MG MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF2Lk[zNUDPxE1? MlO0V2FPT0WU
NCI-H630 NGLGU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLOG1JUUN3ME2xOE43PTZ6IN88US=> Mmq1V2FPT0WU
OVCAR-8 M2\MV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TwWmlEPTB;MUSuO|IxOSEQvF2= NYTqWXJjW0GQR1XS
NCI-H2347 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1zND64NlMh|ryP NETjZpFUSU6JRWK=
BT-549 NHHHVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfNe4htUUN3ME2xOE45Ojh2IN88US=> M4XzbHNCVkeHUh?=
LB831-BLC NIizXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLmTWM2OD1zND64PVM1KM7:TR?= MkjkV2FPT0WU
NCI-H661 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjoTWM2OD1zND65OVkh|ryP NW\BUnplW0GQR1XS
MKN7 M2rydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ITWM2OD1zNT6wNFk{KM7:TR?= MmrJV2FPT0WU
U-87-MG M1nkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D2ZmlEPTB;MUWuNFg6PyEQvF2= NEjwe45USU6JRWK=
OVCAR-4 M4\kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MniyTWM2OD1zNT6xOFI1KM7:TR?= NVHtcJNSW0GQR1XS
OE33 NWHk[FE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjnb4dKSzVyPUG1MlE4OTFizszN NXjoepAzW0GQR1XS
EC-GI-10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqyfnRKSzVyPUG1MlI{PTdizszN M17vZnNCVkeHUh?=
AM-38 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTRd|k{UUN3ME2xOU4zPzF5IN88US=> NW\MXo9{W0GQR1XS
NCI-H1563 NHj0O4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTjPWVEUUN3ME2xOU4{PDlizszN M1vWPXNCVkeHUh?=
SCC-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjjenZPUUN3ME2xOU41OTB|IN88US=> NW\ubmFPW0GQR1XS
Detroit562 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF3LkS1OFch|ryP NIrTbYZUSU6JRWK=
PC-14 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7tRlFKSzVyPUG1MlQ5PjZizszN NHnGWGVUSU6JRWK=
ES3 NGTVNnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGzWpN3UUN3ME2xOU42OzZizszN NHvsO4xUSU6JRWK=
OCI-AML2 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HpWmlEPTB;MUWuO|YyPCEQvF2= NXzNfWFFW0GQR1XS
LU-134-A MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvOTWM2OD1zNT65NFE5KM7:TR?= NXnBSJlIW0GQR1XS
SAS NG\tbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnOVJZKSzVyPUG1Mlk{PzNizszN NGf3dFVUSU6JRWK=
TGBC11TKB M4TJdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7pfVVDUUN3ME2xOU46PDF2IN88US=> NGW1SoRUSU6JRWK=
HOP-62 NX\GVnk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjF[pVwUUN3ME2xOU46PTl5IN88US=> MmLRV2FPT0WU
G-401 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXBc3VMUUN3ME2xOU46PjR7IN88US=> NHKydZVUSU6JRWK=
NCI-H28 NUDLRWFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml72TWM2OD1zNj6wPFU3KM7:TR?= MkDvV2FPT0WU
A204 NXjiTZp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofWTWM2OD1zNj6yNFA3KM7:TR?= NWDMTmZ7W0GQR1XS
NCI-H1299 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF4LkKyPVEh|ryP MoLRV2FPT0WU
VMRC-RCZ NFfzT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf3UVJKSzVyPUG2MlI2QTJizszN M1jORXNCVkeHUh?=
BxPC-3 NU\zPGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\wS2lEPTB;MU[uNlg2PiEQvF2= NWX4[XUxW0GQR1XS
NCI-H2228 M{KySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3HTYxKSzVyPUG2MlUyPThizszN NXHveHdCW0GQR1XS
NCI-H23 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF4Lk[wO|gh|ryP M4\FbXNCVkeHUh?=
NKM-1 NULJfZQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW4UHhKSzVyPUG3MlAyQDlizszN NU\WR4loW0GQR1XS
KYSE-70 NXHKe|FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG2TWM2OD1zNz6yPFkh|ryP M3PRW3NCVkeHUh?=
BB49-HNC MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ic2lEPTB;MUeuOVY5PiEQvF2= M3W1UXNCVkeHUh?=
SCC-15 MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzIcmtJUUN3ME2xO{45PDd|IN88US=> NHnCXY1USU6JRWK=
D-247MG NITCUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XKb2lEPTB;MUeuPVI1PyEQvF2= MV;TRW5ITVJ?
BB30-HNC MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\mXIlKSzVyPUG4MlA{OThizszN NHLr[ZhUSU6JRWK=
CAL-85-1 M1niTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnvTWM2OD1zOD6xPFA6KM7:TR?= NF\zWHdUSU6JRWK=
HT-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV34O5RqUUN3ME2xPE4{QTd5IN88US=> NF3JO2lUSU6JRWK=
KYSE-410 NYj5[odjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Phe2lEPTB;MUiuOFU4PyEQvF2= NV3wdHJVW0GQR1XS
SW982 NVOwN5ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli4TWM2OD1zOD61OlQ6KM7:TR?= MonRV2FPT0WU
SW962 NHrPZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF6LkW3NFIh|ryP M36xbHNCVkeHUh?=
Ramos-2G6-4C10 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD3OotFUUN3ME2xPE42QTJ5IN88US=> MY\TRW5ITVJ?
OC-314 NULCfo1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTF6LkezPFQh|ryP Mnf5V2FPT0WU
LS-123 M4PWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF6Lke5NFEh|ryP MUfTRW5ITVJ?
D-502MG NXyydYJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDKTWM2OD1zOD64NVM6KM7:TR?= NVfjd4w6W0GQR1XS
RO82-W-1 NYeyRXFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\GTWM2OD1zOD64Nlg5KM7:TR?= Mn7JV2FPT0WU
HuO9 M1ntfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\XUnJKSzVyPUG5MlE{PzlizszN Mn7KV2FPT0WU
ETK-1 NFjFZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF7LkG4Nlch|ryP NHvKZ2dUSU6JRWK=
SNU-387 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M131O2lEPTB;MUmuNVg5QSEQvF2= NXr6c5hTW0GQR1XS
SW1573 NHTHOXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XxNGlEPTB;MUmuNVk3QSEQvF2= MWPTRW5ITVJ?
NTERA-S-cl-D1 NIm5OotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TwcWlEPTB;MUmuNlAxPyEQvF2= MWLTRW5ITVJ?
SF126 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETsd|VKSzVyPUG5MlM2ODJizszN MmS1V2FPT0WU
Calu-3 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF7LkSyN|ch|ryP M1\X[XNCVkeHUh?=
NCI-H1048 NUD4bmN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjEOVhKSzVyPUKwMlMzPjZizszN M1jsSXNCVkeHUh?=
NCI-H226 M1u3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTJyLkSzPVkh|ryP NIPhXlFUSU6JRWK=
FTC-133 NGS1RZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\zUmNKSzVyPUKwMlQ4ODNizszN MlXOV2FPT0WU
SF539 M{PDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnCOI16UUN3ME2yNE42OTd{IN88US=> M1HTbXNCVkeHUh?=
TE-6 M2\5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXNTWM2OD1{MD64NFY4KM7:TR?= MV\TRW5ITVJ?
UMC-11 NVP0R3RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjQ[YJuUUN3ME2yNE46OTZ2IN88US=> MVTTRW5ITVJ?
Becker NG\qd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnntTWM2OD1{MT6xNVE5KM7:TR?= MmjnV2FPT0WU
KP-4 NFXG[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXjTWM2OD1{MT6xNVk3KM7:TR?= NYrQZXY6W0GQR1XS
ChaGo-K-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXv[VZKSzVyPUKxMlM3OjdizszN MVvTRW5ITVJ?
CFPAC-1 NF\tS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrIU2dKSzVyPUKxMlM5PThizszN M1jLe3NCVkeHUh?=
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NCI-H1755 NHX6[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37KPWlEPTB;MkGuOlc1OSEQvF2= NV\RWnZKW0GQR1XS
TI-73 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2WGRzUUN3ME2yNk4{OjhizszN MXrTRW5ITVJ?
NCI-H441 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHteJFKSzVyPUKyMlU3QDlizszN NHrCRYxUSU6JRWK=
CaR-1 M4m0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ|LkCyNVMh|ryP M4nidHNCVkeHUh?=
HCC1806 NFrqRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ls[GlEPTB;MkOuNFU5OyEQvF2= MXnTRW5ITVJ?
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EKVX NVW3c3BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki5TWM2OD1{Mz6zPVA6KM7:TR?= M1PHRnNCVkeHUh?=
DMS-114 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPkZWRFUUN3ME2yN{42PzZ3IN88US=> NFfHPVNUSU6JRWK=
A704 NX:yb|hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XpdWlEPTB;MkOuOlExOyEQvF2= M{fTPHNCVkeHUh?=
LC-2-ad M4H1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ|Lk[xOFch|ryP NX\LNGdzW0GQR1XS
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PC-3 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TZbWlEPTB;MkSuNFUzPiEQvF2= MYLTRW5ITVJ?
HEL NFT2OWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLUldyUUN3ME2yOE4xQDZ3IN88US=> MUDTRW5ITVJ?
ABC-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXzToNqUUN3ME2yOE4zPzJ7IN88US=> NVGwZnFCW0GQR1XS
COLO-680N NUS4V4hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PlfmlEPTB;MkSuOFc3PCEQvF2= Mln0V2FPT0WU
MZ1-PC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTvTWM2OD1{ND62PFch|ryP NIHi[4pUSU6JRWK=
NCI-H69 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ixN2lEPTB;MkSuO|M2PCEQvF2= M4jTVXNCVkeHUh?=
TE-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPaUIdKSzVyPUK1MlA1QTlizszN NH:4doRUSU6JRWK=
EW-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTKTWM2OD1{NT6xNVMh|ryP MnS1V2FPT0WU
PANC-08-13 NXrhbpU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTETWM2OD1{NT64NVA{KM7:TR?= M4XqbnNCVkeHUh?=
NMC-G1 M2DKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjIZmpuUUN3ME2yOk4xODh6IN88US=> MYHTRW5ITVJ?
BT-20 NHLPWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTvcXJ2UUN3ME2yOk41PTR|IN88US=> NILJZWxUSU6JRWK=
TGBC24TKB MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zOcmlEPTB;Mk[uO|M{OSEQvF2= NIDzR45USU6JRWK=
TE-11 NYjvV4N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ4Lkm4PVUh|ryP M3\NdXNCVkeHUh?=
ESS-1 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO0dnRKSzVyPUK3MlMzOTZizszN NHHwW45USU6JRWK=
JVM-3 NV7Uc4d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrYNodRUUN3ME2yO{43PDd3IN88US=> MVHTRW5ITVJ?
C3A Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHxcGFsUUN3ME2yO{45PDl4IN88US=> M4q1dnNCVkeHUh?=
MDA-MB-157 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG5fXNKUUN3ME2yO{45PzV|IN88US=> MXfTRW5ITVJ?
KLE NGGxXY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPITWM2OD1{OD6xNFU5KM7:TR?= NXfaZoZYW0GQR1XS
ES1 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojQTWM2OD1{OD6xPFM5KM7:TR?= NFm1T|FUSU6JRWK=
CAL-120 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LSemlEPTB;MkiuN|k6QSEQvF2= MkLFV2FPT0WU
NCI-N87 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG1TWM2OD1{OD61NVA2KM7:TR?= NHez[FdUSU6JRWK=
RPMI-8226 MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVryNWUzUUN3ME2yPU4yQDR|IN88US=> MWXTRW5ITVJ?
COR-L88 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ7LkK0NVkh|ryP NYD0cHhRW0GQR1XS
UACC-893 NEnwXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnETWM2OD1{OT6zNVM4KM7:TR?= M{L3d3NCVkeHUh?=
C8166 M3zy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXxV4lZUUN3ME2yPU46QTl4IN88US=> M4W3RXNCVkeHUh?=
J82 NWTFS2RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNyLkixOFch|ryP MVzTRW5ITVJ?
PFSK-1 NFO1fIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;afZRKSzVyPUOxMlA3PTlizszN NF3LbGVUSU6JRWK=
COLO-684 NH20ZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrPOWxzUUN3ME2zNU41Ozd2IN88US=> NITnVWtUSU6JRWK=
CAL-72 NGTVU5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[0RllUUUN3ME2zNU42PzJ7IN88US=> NYjCb4o5W0GQR1XS
SNB75 M2TRXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTQTWM2OD1|MT64PVch|ryP NFzzfWVUSU6JRWK=
MDA-MB-415 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX6NoxKSzVyPUOxMlk4PjJizszN NITBRZBUSU6JRWK=
SiHa M4T3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX5TWM2OD1|Mj60O|EyKM7:TR?= NUHheIYxW0GQR1XS
NCI-H1648 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\lTWM2OD1|Mj65N|Q2KM7:TR?= MlPSV2FPT0WU
EFO-21 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\vSGlEPTB;M{OuNFA2KM7:TR?= MnHBV2FPT0WU
HCC38 NV3iRW03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDlTWM2OD1|Mz6zPFQyKM7:TR?= NYnwVoVpW0GQR1XS
IA-LM MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTITWM2OD1|Mz63PFg6KM7:TR?= MU\TRW5ITVJ?
CTV-1 NXu3U4d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXONVhKSzVyPUOzMlk4QDZizszN NXPyXWJCW0GQR1XS
NCI-H446 NXzlVnFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17FV2lEPTB;M{SuNlY5QSEQvF2= NWi1NlIzW0GQR1XS
IST-SL1 NWfOWJc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fnZ2lEPTB;M{SuO|QxQCEQvF2= M{P0bXNCVkeHUh?=
EW-22 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN2Lke3OVkh|ryP M3zRWXNCVkeHUh?=
JEG-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETHVZlKSzVyPUO2MlE4PjZizszN NYOwSHI3W0GQR1XS
LU-65 NInjdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN4LkK5PFUh|ryP NGX4UYhUSU6JRWK=
NCI-H596 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor0TWM2OD1|Nj65OVkyKM7:TR?= NUfqS5FrW0GQR1XS
KNS-81-FD M3LZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzmZ4VJUUN3ME2zO{4yPDVizszN MkXKV2FPT0WU
NCI-H1793 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDFO|BKSzVyPUO3MlcxQDZizszN NFLaW5dUSU6JRWK=
NCI-H460 NGTpXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPQ[HQ4UUN3ME2zPE4xQDd|IN88US=> NF\hRpZUSU6JRWK=
MPP-89 M17vZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN7LkW4PFYh|ryP MmTEV2FPT0WU
D-542MG MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvaTWM2OD1|OT64OFM3KM7:TR?= M3rld3NCVkeHUh?=
JAR NEjGWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXzdWdKSzVyPUSwMlQ4ODVizszN M33YbXNCVkeHUh?=
NCI-H209 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\Z[ZlUUUN3ME20NE43PzdizszN NHjU[FhUSU6JRWK=
G-402 M2nBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf3doxKSzVyPUSxMlM6QTNizszN M1zF[nNCVkeHUh?=
IST-MES1 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv4TWM2OD12Mj6xPVM2KM7:TR?= M4rGUXNCVkeHUh?=
Daoy M1jjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj4VJRKSzVyPUSyMlU1PzFizszN MWLTRW5ITVJ?
EW-11 M{LQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzDTWM2OD12Mz6xNlEyKM7:TR?= NXvJSHl4W0GQR1XS
Saos-2 NG\FS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3BTWM2OD12Mz6xOVM4KM7:TR?= Mnu5V2FPT0WU
no-10 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfUNmV2UUN3ME20N{4yPzB{IN88US=> MorhV2FPT0WU
HCC1395 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0TWM2OD12Mz60OlQ1KM7:TR?= NUX2Xo9mW0GQR1XS
HCE-4 M4XEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTR|Lke2OlQh|ryP M4rC[HNCVkeHUh?=
EW-1 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfYUHNKSzVyPUSzMlgxPDlizszN Ml\PV2FPT0WU
OCUB-M MnzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\IS4NHUUN3ME20OE4{PjN6IN88US=> MkjnV2FPT0WU
IGR-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPteoxKSzVyPUS0MlQyOTVizszN MlSxV2FPT0WU
NCI-H1838 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;RT20zUUN3ME20OE41OzR7IN88US=> MnTDV2FPT0WU
NCI-H2405 NInBWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr5T3ZKSzVyPUS0MlU{PCEQvF2= NHTI[mxUSU6JRWK=
GB-1 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHjdmZ7UUN3ME20OE44PDZ|IN88US=> M4XBbnNCVkeHUh?=
MG-63 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\XPZpKSzVyPUS2MlA3QTZizszN MnnmV2FPT0WU
KP-N-YN NHr3UpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR4LkS2O|kh|ryP M1fGNnNCVkeHUh?=
no-11 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rRcmlEPTB;NEeuNFI1PCEQvF2= M1zlVnNCVkeHUh?=
SW948 M4\OcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTR5LkOzO|ch|ryP MULTRW5ITVJ?
CAMA-1 MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESyVZVKSzVyPUS3MlM1OzhizszN M3LCcHNCVkeHUh?=
HCC1187 NEHXToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPT[|dKSzVyPUS3MlUyKM7:TR?= NILjSGRUSU6JRWK=
D-392MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG2TWM2OD12Nz62OVE3KM7:TR?= NFrSfXdUSU6JRWK=
647-V M2rJWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17JfmlEPTB;NEmuN|QyPCEQvF2= MmHsV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK1/2 / ERK1/2 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK1/2 in sympathetic neurons. Immunoblots were performed with whole cell extracts from sympathetic neurons maintained in the presence of NGF and left untreated or treated with PD184352 at 0.1, 1, 2 or 10 μM for 16 hours. Antibodies to detect total ERK1/2 and phospho-ERK1/2 were used. 

p-ERK5 / ERK5 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK5 in sympathetic neurons.

21762482
Growth inhibition assay
Cell viability; 

PubMed: 29989268     


Relative viability of DU145CR cells treated with PD184352 was significantly less than that of DU145 cells in WST assay. 

29989268
In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

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MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

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  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: PTC cells in athymic mice
  • Formulation: Cremophor EL–95% ethanol (50:50) and dilutes with water
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID