PD184352 (CI-1040)

For research use only.

Catalog No.S1020

88 publications

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 140 In stock
USD 70 In stock
USD 120 In stock
USD 270 In stock
USD 670 In stock
USD 770 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's PD184352 (CI-1040) has been cited by 88 publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 NYnBZY5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXSVnRsUUN3ME2wMlAzOjd4IN88US=> NHLsdnJUSU6JRWK=
CHP-212 NEW1XoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzzNVdIUUN3ME2wMlAzQDh3IN88US=> NFjqfGNUSU6JRWK=
EoL-1-cell NYPkWXNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m1VmlEPTB;MD6wOFE2OiEQvF2= NYntS4NqW0GQR1XS
DU-4475 M4XqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3CVnBKSzVyPUCuNFc2QTlizszN MUHTRW5ITVJ?
MMAC-SF MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMUC5O|Qh|ryP MVnTRW5ITVJ?
AGS MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzFb|IzUUN3ME2wMlEyPzF|IN88US=> MkS1V2FPT0WU
M14 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrkTlRKSzVyPUCuNVU1PjhizszN M4HxNXNCVkeHUh?=
CP50-MEL-B M4\uUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXjTWM2OD1yLkG3NlU1KM7:TR?= MWfTRW5ITVJ?
C32 M1TGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDzPWRKSzVyPUCuNVkxPzJizszN MlPLV2FPT0WU
KMOE-2 M3HSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XZVWlEPTB;MD6xPVc6PSEQvF2= M{DQbnNCVkeHUh?=
A101D NXLxUYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMkG0JO69VQ>? NFLtNHpUSU6JRWK=
KM12 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVO2S45KUUN3ME2wMlI1ODV5IN88US=> MXfTRW5ITVJ?
HSC-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoO0TWM2OD1yLkK0N|k2KM7:TR?= NUnmcHFPW0GQR1XS
NOMO-1 M4X4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMkW3OFIh|ryP MV;TRW5ITVJ?
MZ7-mel MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrNXIhKUUN3ME2wMlI3OzRizszN NEnxV4lUSU6JRWK=
ACN NHLBXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HOeGlEPTB;MD6yOlc{PyEQvF2= MVzTRW5ITVJ?
MEL-HO MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW5TWM2OD1yLkK3OlUzKM7:TR?= M1HNd3NCVkeHUh?=
BHT-101 M13TTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzY[|VKSzVyPUCuNlg3ODZizszN NGX4b|FUSU6JRWK=
SK-MEL-28 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofiTWM2OD1yLkOwOFA6KM7:TR?= MUfTRW5ITVJ?
KG-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYThT5pVUUN3ME2wMlMxPjZ6IN88US=> MUjTRW5ITVJ?
COLO-679 M4\GXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwM{K3NkDPxE1? NF\UeHNUSU6JRWK=
SK-MEL-24 NFrHdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHwR|ZKSzVyPUCuN|I5OTNizszN NIP1NlZUSU6JRWK=
G-361 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVqzUlg3UUN3ME2wMlM3Pzl3IN88US=> MoHYV2FPT0WU
KY821 NIT2[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwM{e5NUDPxE1? MkDEV2FPT0WU
KASUMI-1 NHz3VGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SwfGlEPTB;MD6zPVkh|ryP NYXBeZJ{W0GQR1XS
HL-60 NGLlWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O5c2lEPTB;MD60NVExPyEQvF2= MWrTRW5ITVJ?
K5 M334fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3GR3RvUUN3ME2wMlQ{OTF5IN88US=> MnuzV2FPT0WU
KU812 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P5fWlEPTB;MD60OVI6QSEQvF2= MVjTRW5ITVJ?
SH-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzhdlJDUUN3ME2wMlQ3OjV4IN88US=> MnGyV2FPT0WU
HTC-C3 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknoTWM2OD1yLkS2OVMyKM7:TR?= MmHHV2FPT0WU
CP66-MEL NHjofWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHXTWM2OD1yLkS4PFA6KM7:TR?= NUnMUo9CW0GQR1XS
WM-115 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXiTWM2OD1yLkS5NlU4KM7:TR?= MXHTRW5ITVJ?
A2780 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUXmlEPTB;MD60PVgzOyEQvF2= MmH5V2FPT0WU
P12-ICHIKAWA M3Xrcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vvR2lEPTB;MD62NVIzOSEQvF2= NITtUFJUSU6JRWK=
HMV-II MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LnSGlEPTB;MD62OFQ3PSEQvF2= NIS4R3VUSU6JRWK=
HT-144 M3jrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwNkS2OVch|ryP M{XMZnNCVkeHUh?=
LB2518-MEL NX\ScHVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzmUJlKSzVyPUCuO|E3OzJizszN MX;TRW5ITVJ?
NCI-SNU-1 NFnEOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;OTWM2OD1yLke1OFM{KM7:TR?= M3;ocHNCVkeHUh?=
C2BBe1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3iwWWlEPTB;MD64NVAzOyEQvF2= NYDXd5hpW0GQR1XS
PSN1 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LQdmlEPTB;MD65OlE6PiEQvF2= NGj1OVZUSU6JRWK=
UACC-257 NITOWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HYS2lEPTB;MD65OlQ4OyEQvF2= NIe0[HRUSU6JRWK=
RVH-421 M2fIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLTTWM2OD1yLkm3NVgh|ryP M33VTHNCVkeHUh?=
GP5d MoTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfzTWM2OD1yLkm4N|A5KM7:TR?= NH\DS41USU6JRWK=
TYK-nu M3rycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnT[GlKSzVyPUGuNFMyPzJizszN MmPRV2FPT0WU
SK-N-AS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDyXm9oUUN3ME2xMlA4QTR5IN88US=> NUHHdVVnW0GQR1XS
SW620 NGHUXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13GbmlEPTB;MT6xN|U{PCEQvF2= MYLTRW5ITVJ?
HuP-T4 M{ezfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxOWlEPTB;MT6xPFM2QSEQvF2= Mn7zV2FPT0WU
A549 NWfjd41UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXD[HZKSzVyPUGuNVk2PzZizszN M1LyVXNCVkeHUh?=
Mewo MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwMkCyO|Yh|ryP NHjzdGlUSU6JRWK=
ONS-76 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOwWZBKSzVyPUGuNlIxPDlizszN NHK3RoJUSU6JRWK=
SK-MEL-1 M1nDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULNWWVmUUN3ME2xMlI{PDF7IN88US=> NX3FN5JoW0GQR1XS
RCM-1 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwMkSwOFch|ryP NV\KUoY1W0GQR1XS
H-EMC-SS NIHzSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSwSWtKSzVyPUGuNlk3ODhizszN MXLTRW5ITVJ?
NCI-H2291 NV7UU4hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHtTWM2OD1zLkOyOVM3KM7:TR?= NUKwXpc{W0GQR1XS
SW1463 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTzRVRKSzVyPUGuN|M4OjFizszN NH;HSlRUSU6JRWK=
LS-411N M2Xqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojoTWM2OD1zLkSwOVE4KM7:TR?= NEm0PGtUSU6JRWK=
BV-173 M2PXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;mTWM2OD1zLkS0NFE2KM7:TR?= NGrabldUSU6JRWK=
LS-513 M{XlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFwNEWxPVIh|ryP MXXTRW5ITVJ?
LoVo MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fEVmlEPTB;MT60OlM6QSEQvF2= MX\TRW5ITVJ?
HO-1-N-1 NXHXU4xIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXRNFJKSzVyPUGuOVE3OzRizszN M2fpN3NCVkeHUh?=
ML-2 M1\HOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPSRo5KSzVyPUGuOVI5PjhizszN M3XaRnNCVkeHUh?=
NCI-H1437 M1rZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwNUWyO|Uh|ryP NGX0bnNUSU6JRWK=
SW1116 NV7sfYh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSzTpBEUUN3ME2xMlU3Ozl6IN88US=> NUHQc4pxW0GQR1XS
A4-Fuk MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHlSWx6UUN3ME2xMlU4ODR3IN88US=> NGrXVWlUSU6JRWK=
HD-MY-Z NWfQZ5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\FPJk5UUN3ME2xMlU4Ozd4IN88US=> NX\hRZh[W0GQR1XS
SK-MEL-2 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwNUe0OVkh|ryP NIPU[pdUSU6JRWK=
RT-112 M3ewZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFwNUi5OVIh|ryP MUTTRW5ITVJ?
COLO-829 NVnHNVhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTxeY9rUUN3ME2xMlYzOjN{IN88US=> MkKzV2FPT0WU
OVCAR-5 NF\2PVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml75TWM2OD1zLke3Olg4KM7:TR?= M1\mfXNCVkeHUh?=
NB69 M2TncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fWW2lEPTB;MT63PFQ3QSEQvF2= NUDxXpl7W0GQR1XS
NCI-H292 NX7zN3lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLDPIRKSzVyPUGuPFY3QTlizszN Ml3QV2FPT0WU
LOXIMVI NXvZbnNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7LTWM2OD1zLki5OFI4KM7:TR?= NVPDW4FoW0GQR1XS
BPH-1 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTFwOEm1PVEh|ryP M3TwVXNCVkeHUh?=
A375 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwOEm3NVQh|ryP Mnf0V2FPT0WU
LCLC-97TM1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwOUKyOVYh|ryP MV\TRW5ITVJ?
RXF393 NHLLRmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwOUe4PFch|ryP MnrCV2FPT0WU
HCC70 M3PIbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfUfFVKSzVyPUKuNFI1OjZizszN M4TsTnNCVkeHUh?=
EM-2 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrrTWM2OD1{LkC3NVk5KM7:TR?= MorQV2FPT0WU
MZ2-MEL M4rsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLCNoxwUUN3ME2yMlEyOTJ5IN88US=> MU\TRW5ITVJ?
HN MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\XZmlEPTB;Mj6xOlI4QCEQvF2= MnzjV2FPT0WU
A2058 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLIbJlKSzVyPUKuNVkzPzlizszN NUXaV3MyW0GQR1XS
NB7 MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwM{SwPFYh|ryP MUDTRW5ITVJ?
DOK NH3TcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H4WGlEPTB;Mj6zOVc4OyEQvF2= NV3KbHc5W0GQR1XS
CAL-27 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJwM{myN|Yh|ryP NIL3XJNUSU6JRWK=
BB65-RCC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXOTWM2OD1{LkSwOlc1KM7:TR?= MWXTRW5ITVJ?
RD MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJwNES3NlMh|ryP MXXTRW5ITVJ?
KNS-62 NVfxe5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPBWVBKSzVyPUKuOVEyPjRizszN Ml\3V2FPT0WU
EW-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe2XZFKSzVyPUKuOVY{OzlizszN M1r0fnNCVkeHUh?=
DB NIntNXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnqTWM2OD1{LkW4O|g5KM7:TR?= NEHSNItUSU6JRWK=
HCC2218 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDCVGM1UUN3ME2yMlY1Pzd6IN88US=> MXfTRW5ITVJ?
L-363 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fyNGlEPTB;Mj63OFM4KM7:TR?= MULTRW5ITVJ?
CHL-1 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn0TWM2OD1{LkiwO|g2KM7:TR?= NFrv[XpUSU6JRWK=
BFTC-905 NYTiW4l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwOEK1N{DPxE1? MYHTRW5ITVJ?
HCE-T MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TURmlEPTB;Mj64N|I3PCEQvF2= NHu3UXVUSU6JRWK=
COLO-792 MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPySWJKSzVyPUKuPFQxOjdizszN MVzTRW5ITVJ?
LB2241-RCC NHzRbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwOEW4PVMh|ryP Mn7EV2FPT0WU
CAL-39 NYP2cWF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXzUnRKSzVyPUKuPFk6QTlizszN M3jkXnNCVkeHUh?=
T-24 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vMSWlEPTB;Mj65NVEyOiEQvF2= MlXmV2FPT0WU
NCI-H727 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJwOUG3PVYh|ryP MU\TRW5ITVJ?
Ca9-22 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHzWI1KSzVyPUKuPVczPTVizszN MVjTRW5ITVJ?
MIA-PaCa-2 NWXW[JRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIUI94UUN3ME2zMlAxPzhzIN88US=> NW[3VVFTW0GQR1XS
HT-1080 M1rxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDWTWM2OD1|LkCxPVk4KM7:TR?= MWPTRW5ITVJ?
D-423MG NIjoN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL4d|hKSzVyPUOuNFc4PTNizszN NF31TlhUSU6JRWK=
LAMA-84 NHu5Vo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDyTWM2OD1|LkGzOVgh|ryP M1:yPHNCVkeHUh?=
SW780 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrjTWM2OD1|LkG0NlI6KM7:TR?= NXHsXYVFW0GQR1XS
KU-19-19 NFTGT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfTOGNKSzVyPUOuNVcxOzRizszN MmGzV2FPT0WU
COLO-741 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn5NZZ3UUN3ME2zMlE5Pjd|IN88US=> MlzGV2FPT0WU
HSC-3 M1jhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwMkOxOVEh|ryP M1fHZXNCVkeHUh?=
SN12C M1XTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNwMkS3NFEh|ryP MmrsV2FPT0WU
786-0 NX\DcIlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vEVWlEPTB;Mz6yO|I1OyEQvF2= MX7TRW5ITVJ?
GAK MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\s[5BKSzVyPUOuN|I2PjFizszN M4O5XnNCVkeHUh?=
PANC-03-27 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX6TWM2OD1|LkO1NFQ2KM7:TR?= MmTVV2FPT0WU
CTB-1 M2PIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rzeWlEPTB;Mz60O|A1PyEQvF2= NInDVlRUSU6JRWK=
A427 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\TXWlEPTB;Mz61PVU2PiEQvF2= MnG3V2FPT0WU
EGI-1 NInjcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjOTWM2OD1|Lk[wOVg{KM7:TR?= NHHiO2hUSU6JRWK=
U-2-OS NVTJfnJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vkb2lEPTB;Mz62O|I2PiEQvF2= M2Ppd3NCVkeHUh?=
NCI-SNU-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqTWM2OD1|Lk[3O|Mh|ryP NH7qOJBUSU6JRWK=
SK-LU-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7UTWM2OD1|Lk[4O|k5KM7:TR?= NETvdGtUSU6JRWK=
697 NWTLfWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ZWmlEPTB;Mz62PVYxOyEQvF2= MWfTRW5ITVJ?
HPAF-II M3zBc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT1THdYUUN3ME2zMlc2PDlizszN NU\1cZBOW0GQR1XS
NCI-H2087 NXXqPYQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwOES2O|Ih|ryP NWTt[3p1W0GQR1XS
SK-MEL-3 M3KzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6zTWM2OD1|Lki1NVU1KM7:TR?= NFy5SI1USU6JRWK=
CGTH-W-1 NHzOelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnN[YtEUUN3ME2zMlg2PzJ3IN88US=> NXPBV493W0GQR1XS
8505C NE\weJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTNwOUCwO|gh|ryP NFrHeWZUSU6JRWK=
GAMG MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHqTpR7UUN3ME20MlAzOzd5IN88US=> M3vrT3NCVkeHUh?=
SW626 NYe2WXE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC0RXJVUUN3ME20MlA1PDhizszN MYHTRW5ITVJ?
CAL-62 NEjHUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPScYJoUUN3ME20MlA4PDNizszN MkHZV2FPT0WU
MHH-PREB-1 M{LTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnHTWM2OD12LkGyNVEyKM7:TR?= NWnmPWpvW0GQR1XS
RPMI-7951 MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITweJZKSzVyPUSuNlU2QDlizszN NWXwXWhPW0GQR1XS
HOP-92 NGXIXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rHeWlEPTB;ND6yOVY4KM7:TR?= MkfuV2FPT0WU
MDA-MB-231 M2fKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mln3TWM2OD12LkK5NlI{KM7:TR?= NGLkcWVUSU6JRWK=
LAN-6 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[5d|E3UUN3ME20MlMyPjN5IN88US=> NWHi[XhSW0GQR1XS
ALL-PO NV[yZ|k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjCcVJKSzVyPUSuN|YyPTZizszN MluyV2FPT0WU
HH NUXiTIhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonYTWM2OD12LkSxOVk4KM7:TR?= M1z4WHNCVkeHUh?=
IGROV-1 M4ryOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq4TWM2OD12LkS1NVcyKM7:TR?= MmHOV2FPT0WU
NCI-H358 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnrWWpGUUN3ME20MlQ2Ozh3IN88US=> NXf1OIJNW0GQR1XS
NB5 NImyO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV34clJjUUN3ME20MlYxOzZ7IN88US=> NWS0b4Y5W0GQR1XS
NCI-H747 NICxfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qybWlEPTB;ND62PFgxPyEQvF2= M1XEV3NCVkeHUh?=
NH-12 Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHte2JKSzVyPUSuO|E3OjVizszN NXexPVBZW0GQR1XS
LB1047-RCC M3n3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTRwN{O4NVUh|ryP Mn7FV2FPT0WU
EFO-27 NUfZVHpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmxSmR[UUN3ME20Mlc5PjZ5IN88US=> NGr2cHdUSU6JRWK=
EPLC-272H M1nk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfBTWM2OD12Lkm5OlY6KM7:TR?= MYTTRW5ITVJ?
CAL-54 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7hTWM2OD13LkCyOlk2KM7:TR?= MnLuV2FPT0WU
H4 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O0[2lEPTB;NT6wOFI2PSEQvF2= NGfHSphUSU6JRWK=
MOLT-13 NGqzXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TGb2lEPTB;NT6wOlc4PiEQvF2= NFSxUW1USU6JRWK=
CAL-33 NFjUc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHOO5BCUUN3ME21MlEzOzF5IN88US=> NVrUVYtZW0GQR1XS
23132-87 NHzFS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj5UlhKSzVyPUWuNVY5PzJizszN MWfTRW5ITVJ?
UM-UC-3 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTVwMUiwOFch|ryP NXXCT2pzW0GQR1XS
HuH-7 NGnOdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnhTWM2OD13LkK3NVQ4KM7:TR?= MV\TRW5ITVJ?
BCPAP M3G5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\0cGlEPTB;NT6zNlk3QSEQvF2= NVj2VZBTW0GQR1XS
AsPC-1 NFzFbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTVwM{[3OlMh|ryP M{[2ZnNCVkeHUh?=
NCI-H1155 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTVwNECwOVEh|ryP MmHVV2FPT0WU
GT3TKB M1XqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nk[GlEPTB;NT60OlU6QCEQvF2= NVXTclFlW0GQR1XS
HCC2998 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;0TWM2OD13LkS5NVA6KM7:TR?= M4rEN3NCVkeHUh?=
NUGC-3 NU\CcmZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXiTWM2OD13LkS5N|AzKM7:TR?= NWD2[4s2W0GQR1XS
Hs-578-T M3fTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrHXWJDUUN3ME21MlU{Pzl2IN88US=> NVLROYo4W0GQR1XS
FADU NGXORlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTVwNUW3NlYh|ryP MkezV2FPT0WU
NBsusSR NVS4UlFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3GSJhDUUN3ME21MlU4OTV3IN88US=> NXvsd4NyW0GQR1XS
ME-180 NUnuT4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG5SZRpUUN3ME21MlU5ODl{IN88US=> NGe5dHVUSU6JRWK=
SW1710 M1zHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jUNWlEPTB;NT62NVY2PCEQvF2= NF3ONXhUSU6JRWK=
HuP-T3 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[zcplKSzVyPUWuOlIxOjlizszN NVrtfFI4W0GQR1XS
HOS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTVwNkK5NlMh|ryP MXjTRW5ITVJ?
PA-1 M2jQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTVwNkSyOlUh|ryP MVzTRW5ITVJ?
LU-99A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTVwNk[0OVEh|ryP NWDWe2d[W0GQR1XS
RS4-11 NXPpbnU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnQd5FTUUN3ME21MlY3Pzd3IN88US=> NXvaSXIzW0GQR1XS
TE-8 M{LScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzETWM2OD13Lk[4OVM4KM7:TR?= MlvPV2FPT0WU
RERF-LC-MS NFr1S3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHmPVVKSzVyPUWuOlg5ODNizszN M1TlOnNCVkeHUh?=
MEL-JUSO MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTVwN{O3PEDPxE1? NYjxZWlOW0GQR1XS
SK-MES-1 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTVwOEO1Nlgh|ryP MX7TRW5ITVJ?
D-263MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTVwOEizOVEh|ryP NVO5R|UzW0GQR1XS
NB10 NXfvO4V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PnTmlEPTB;NT64PVQ3KM7:TR?= M2\LPXNCVkeHUh?=
SK-HEP-1 NX36b3hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTVwOUO0O|Eh|ryP MX\TRW5ITVJ?
HT-29 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LpeWlEPTB;NT65PFEyQCEQvF2= M4rGUHNCVkeHUh?=
KYSE-140 M2HP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\5R4NnUUN3ME22MlAzOTh{IN88US=> M332eHNCVkeHUh?=
NCI-H1666 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTZwMEi0OlEh|ryP NX7tOnlXW0GQR1XS
NCI-H1304 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXX[WVKSzVyPU[uNVk6PCEQvF2= MWfTRW5ITVJ?
RPMI-8866 M{fWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\yZmxVUUN3ME22MlIyOzF|IN88US=> NHP4O|ZUSU6JRWK=
MV-4-11 NF7F[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjsUJo2UUN3ME22MlI{OTl7IN88US=> MXTTRW5ITVJ?
A431 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr2b|NKSzVyPU[uNlQzQTZizszN M1j3enNCVkeHUh?=
PANC-10-05 M4PiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\yU4lnUUN3ME22MlI5OzZ|IN88US=> M{DoWnNCVkeHUh?=
TK10 NIDZenBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HjRWlEPTB;Nj6zNlYxPCEQvF2= NXPmTIk3W0GQR1XS
NCI-H1975 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD14LkS3NlE2KM7:TR?= NUTuVmp1W0GQR1XS
A172 NXThWWpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL6VpZKSzVyPU[uOFkyPzZizszN MVPTRW5ITVJ?
D-566MG NGDldWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLMWIY4UUN3ME22MlU1OzB|IN88US=> MULTRW5ITVJ?
NCI-H2122 NIfVNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTZwNkG1Nlgh|ryP MnjiV2FPT0WU
COR-L105 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELpPY1KSzVyPU[uOlUzPzVizszN M2KyW3NCVkeHUh?=
AN3-CA Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmyOolKSzVyPU[uOlg3PDFizszN MYHTRW5ITVJ?
Calu-6 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTZwN{m2PVgh|ryP M{X2c3NCVkeHUh?=
HCT-116 NGLJUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvIWJBDUUN3ME22MlgyOjZ2IN88US=> MWLTRW5ITVJ?
MHH-NB-11 NX3US2pwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDTbVVKSzVyPU[uPFUxODJizszN MU\TRW5ITVJ?
MFE-280 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHPWVlnUUN3ME22Mlg2QTh|IN88US=> M{LxTHNCVkeHUh?=
SW1088 NH;5NmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W1XWlEPTB;Nj65NVkyOyEQvF2= NF\pc4RUSU6JRWK=
SW48 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnHTWM2OD14Lkm0OVEh|ryP MYHTRW5ITVJ?
HuCCT1 NV3MdFY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3KT|BKSzVyPUeuNFExOzdizszN M4rCb3NCVkeHUh?=
ACHN M1v2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofBTWM2OD15LkCyPVQ{KM7:TR?= NEXsRY1USU6JRWK=
8305C NHyz[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXDZ4diUUN3ME23MlA6QTl3IN88US=> NED4dGZUSU6JRWK=
DoTc2-4510 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn4W5plUUN3ME23MlEzOTVizszN NFWzR5lUSU6JRWK=
COR-L23 NXnlOop{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\nTWM2OD15LkK0OFIh|ryP NXTCdpRuW0GQR1XS
SK-MEL-30 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n2dWlEPTB;Nz6yOVA5OyEQvF2= M{nIc3NCVkeHUh?=
BE-13 NVvmUZVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTdwM{O4N|Qh|ryP MlPoV2FPT0WU
GR-ST M3PEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;wV4lKSzVyPUeuOFAyPzRizszN Mmm2V2FPT0WU
LU-135 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTdwNUW5N|kh|ryP NHXSOJJUSU6JRWK=
U-266 NEHwPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTdwNU[yPFYh|ryP M2\kfnNCVkeHUh?=
NCI-H1355 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33QOmlEPTB;Nz61PFY{PSEQvF2= NYPwUmt{W0GQR1XS
NB14 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfyTWM2OD15Lk[2OlQzKM7:TR?= MWrTRW5ITVJ?
SCC-25 NHzGTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j6ZWlEPTB;Nz63NFkh|ryP NWr6[oduW0GQR1XS
COLO-678 M3T0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTdwN{GwO|Yh|ryP Mn[0V2FPT0WU
TGBC1TKB M2H3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfjTWM2OD15Lki5N|k5KM7:TR?= M3j2V3NCVkeHUh?=
IST-MEL1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvFVpZKSzVyPUiuNFA1ODZizszN MVfTRW5ITVJ?
ECC10 M2H4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7DN4dKSzVyPUiuNFM{QTVizszN M1PwU3NCVkeHUh?=
EW-16 M2nEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPGTWM2OD16LkC4OFQ2KM7:TR?= MkK1V2FPT0WU
DOHH-2 NV75OnZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3LTWM2OD16LkKwNFk2KM7:TR?= NIfqbZpUSU6JRWK=
NCI-H1581 M4\EVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjWTWh1UUN3ME24MlI3OzJ|IN88US=> Ml\TV2FPT0WU
TE-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPIUHViUUN3ME24MlQzPDJ7IN88US=> MonzV2FPT0WU
CAKI-1 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRThwNUeyNlIh|ryP MXrTRW5ITVJ?
A673 MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DuNWlEPTB;OD62N|IxOiEQvF2= M1:xXnNCVkeHUh?=
CAL-12T MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\JPFFyUUN3ME24MlY2PzV|IN88US=> MkHHV2FPT0WU
DBTRG-05MG M2jBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRThwN{S4OVkh|ryP NFriVJhUSU6JRWK=
SK-N-FI M2XDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRThwOEGzO|kh|ryP NY\Vd|lsW0GQR1XS
K-562 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD16LkizPVU4KM7:TR?= M{ftUnNCVkeHUh?=
SBC-1 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPISZBKSzVyPUiuPFY3PDVizszN MV3TRW5ITVJ?
ES4 NVmyNWhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K0cGlEPTB;OD64Olg5PCEQvF2= MofZV2FPT0WU
MS-1 NEPkd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LXN2lEPTB;OD64O|UyPyEQvF2= NFWzOZlUSU6JRWK=
RKO NV\p[HJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRThwOEmwOVch|ryP NWDhOHF7W0GQR1XS
NCI-H1693 M3S1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRThwOUKxO{DPxE1? Mlj4V2FPT0WU
SW954 NEnnXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO4fVRKSzVyPUiuPVY6PzhizszN MXjTRW5ITVJ?
SK-UT-1 NFjVN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHyTWM2OD16Lkm3Olg{KM7:TR?= MlzsV2FPT0WU
T98G NUTEcnlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRThwOUm4OFYh|ryP NIXGeIlUSU6JRWK=
NCI-H2126 M{DsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;CSpBbUUN3ME25MlAxQDJ4IN88US=> MWjTRW5ITVJ?
TE-12 NYf1fnNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHIT|BtUUN3ME25MlA{OzZ5IN88US=> MU\TRW5ITVJ?
DK-MG M3PjZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC3TWM2OD17LkKxNVkyKM7:TR?= NWL3Sm82W0GQR1XS
MEG-01 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iy[2lEPTB;OT6yOFk{OSEQvF2= MmruV2FPT0WU
HCC1937 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTuR2dwUUN3ME25MlI6ODlzIN88US=> M3[2fHNCVkeHUh?=
MKN45 NGTvbFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ZZWlEPTB;OT60OVA3PSEQvF2= NFTNOWlUSU6JRWK=
NCI-H1792 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj6V3NKSzVyPUmuOFUzOTlizszN M33FSHNCVkeHUh?=
SW1417 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPJTWM2OD17LkW2PFM4KM7:TR?= M2P3SnNCVkeHUh?=
639-V MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOxdnNKSzVyPUmuOlQ{QDhizszN Ml\4V2FPT0WU
P30-OHK NIm1XpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITqUo1KSzVyPUmuOlU{OTZizszN M3mzc3NCVkeHUh?=
YKG-1 NYPpdWNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\iTWM2OD17Lke1NFM{KM7:TR?= NX3iRXpUW0GQR1XS
KGN NY\qPJdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2xWXpKSzVyPUmuPFM4QTVizszN MWDTRW5ITVJ?
MSTO-211H M4T5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzIZ3g5UUN3ME25Mlk2PTJ7IN88US=> M{e4NnNCVkeHUh?=
NCI-H1573 NELQc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TndWlEPTB;MUCuNVU4PCEQvF2= NYPGeGg4W0GQR1XS
NCI-H720 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFyLkG5PFkh|ryP MnXKV2FPT0WU
KARPAS-45 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvySIdKSzVyPUGwMlI4QTVizszN MVHTRW5ITVJ?
MDA-MB-175-VII Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTqTWM2OD1zMD60PEDPxE1? Ml7FV2FPT0WU
SK-NEP-1 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLrcXdKSzVyPUGwMlQ6QDFizszN MknwV2FPT0WU
MKN28 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTDTWM2OD1zMD61NVgh|ryP MYjTRW5ITVJ?
KYSE-520 NWXOXG9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S3T2lEPTB;MUCuOVIh|ryP NVXwd29FW0GQR1XS
KE-37 M4P3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO2SodKSzVyPUGwMlUzPzJizszN M1zJcHNCVkeHUh?=
VA-ES-BJ M{DBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHKN2VjUUN3ME2xNE42PjdizszN MnnxV2FPT0WU
CCRF-CEM NV;MblFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPmTWM2OD1zMD61Olg1KM7:TR?= MkG5V2FPT0WU
GMS-10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrKPJkyUUN3ME2xNE43ODl2IN88US=> NIT6e29USU6JRWK=
NCI-H1623 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33HcGlEPTB;MUCuOlM4QSEQvF2= M{TlZXNCVkeHUh?=
NEC8 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXwfm5OUUN3ME2xNE44Pzd|IN88US=> MUDTRW5ITVJ?
MOLT-16 NUfYXlhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[0ZmlEPTB;MUCuPFEyOyEQvF2= NHLKdGJUSU6JRWK=
DJM-1 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KwRWlEPTB;MUGuNFM4QSEQvF2= NX20eHJCW0GQR1XS
U251 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLkR4l3UUN3ME2xNU4xPDJizszN MnXyV2FPT0WU
SBC-5 M{jBTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFzLkG0Olch|ryP NED1R29USU6JRWK=
SW756 MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoroTWM2OD1zMT6yNVU1KM7:TR?= M3zuRXNCVkeHUh?=
KS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln3TWM2OD1zMT6yOlE6KM7:TR?= M1:xcHNCVkeHUh?=
SF295 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHRTWM2OD1zMT6zNVA1KM7:TR?= NFXnWXdUSU6JRWK=
YH-13 M1vWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LrWWlEPTB;MUGuN|I3PyEQvF2= NVG3TpAxW0GQR1XS
SW837 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnFV2U{UUN3ME2xNU4{PTB4IN88US=> MWHTRW5ITVJ?
KYSE-450 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFzLkSwOVch|ryP MlzNV2FPT0WU
KYSE-180 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFzLkS4NkDPxE1? M4XKc3NCVkeHUh?=
S-117 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLTTWM2OD1zMT60PFk3KM7:TR?= MYPTRW5ITVJ?
KOSC-2 M2DIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfHZmc1UUN3ME2xNU43OjJ{IN88US=> M{[wc3NCVkeHUh?=
KYSE-270 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELOcHpKSzVyPUGxMlg4PDVizszN NXXhdJk1W0GQR1XS
D-336MG MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFzLkmwO|Uh|ryP M{jqWHNCVkeHUh?=
KALS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF{LkCwNVYh|ryP M2jnV3NCVkeHUh?=
LB373-MEL-D NYTiN5hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHkdnBEUUN3ME2xNk4xPTN|IN88US=> NIPkUFhUSU6JRWK=
HLE NYDUN3FlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF{LkC1PFUh|ryP M2HjbnNCVkeHUh?=
SJSA-1 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTFUlZKSzVyPUGyMlA4OzVizszN M2Psc3NCVkeHUh?=
SW1990 NXTZdpZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF{LkC5NVEh|ryP NXPye291W0GQR1XS
NOS-1 NUnYRYFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKwSZRKSzVyPUGyMlE{PTJizszN M4fv[3NCVkeHUh?=
GI-ME-N M4fNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\BO3BtUUN3ME2xNk4zOTZ|IN88US=> NVTYcGpiW0GQR1XS
NCI-H1703 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD1eYhKSzVyPUGyMlI3OTZizszN MUjTRW5ITVJ?
ES7 NELoO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PIWGlEPTB;MUKuNlczPCEQvF2= MkC4V2FPT0WU
KYSE-510 MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV60XW1GUUN3ME2xNk42ODd7IN88US=> MVPTRW5ITVJ?
BHY MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvNTWM2OD1zMj61N|A4KM7:TR?= NHi4UVVUSU6JRWK=
TCCSUP M3XRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n5[mlEPTB;MUKuOVc2PyEQvF2= MVfTRW5ITVJ?
HSC-2 NGjyNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX3cZhKSzVyPUGyMlU6QTZizszN NIHGd49USU6JRWK=
BEN NXjGO3pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\RPIVSUUN3ME2xNk43OTR|IN88US=> MVHTRW5ITVJ?
769-P MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF{Lke5NlQh|ryP NH3yPVhUSU6JRWK=
HT NEP1e4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF{LkizOFYh|ryP MXrTRW5ITVJ?
LXF-289 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r1TmlEPTB;MUKuPVU{OSEQvF2= MkGwV2FPT0WU
OVCAR-3 NHPSNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF{Lkm1Olch|ryP M2LUXnNCVkeHUh?=
ATN-1 M2W3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4foNGlEPTB;MUOuNFE5PCEQvF2= NVjvVXFSW0GQR1XS
8-MG-BA M3uxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjTcFJKSzVyPUGzMlA1PTVizszN MYnTRW5ITVJ?
SW13 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD6TW5HUUN3ME2xN{4yOTZ3IN88US=> Ml;mV2FPT0WU
NCI-H1092 M3XZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XVcGlEPTB;MUOuNVYzKM7:TR?= NVLFcFF{W0GQR1XS
OAW-42 Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX1bnNKSzVyPUGzMlE6OzdizszN NWfxfG44W0GQR1XS
NCI-H2452 M2\QR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HKe2lEPTB;MUOuNlE4PSEQvF2= MV3TRW5ITVJ?
CAPAN-1 NGTpbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\zeJNKSzVyPUGzMlU2OTRizszN Mn61V2FPT0WU
NCI-H2009 NGPJVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf4TWM2OD1zMz61PVE6KM7:TR?= NUnM[XZEW0GQR1XS
SF268 M{DJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\vU4hKSzVyPUGzMlY{OjZizszN NUXyUoM5W0GQR1XS
GCIY NWPYfm9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HORWlEPTB;MUOuOlkzPyEQvF2= NWXBemZsW0GQR1XS
OS-RC-2 NHWxd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C5VGlEPTB;MUOuPVUxOSEQvF2= NHvSSoFUSU6JRWK=
GCT M2rZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M123PWlEPTB;MUOuPVY6PyEQvF2= M2O2dHNCVkeHUh?=
NB17 M1;mV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TZR2lEPTB;MUSuNFg2KM7:TR?= NG\vN5FUSU6JRWK=
NCI-H2030 M3rZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLVeHpmUUN3ME2xOE4yPDZ3IN88US=> M13SVXNCVkeHUh?=
HC-1 M4jzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTF2LkKwPFch|ryP Mn3jV2FPT0WU
QIMR-WIL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn3V3JRUUN3ME2xOE4{PDF{IN88US=> M1G0RnNCVkeHUh?=
Capan-2 NH\leZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0NGhKSzVyPUG0MlM4OTRizszN MU\TRW5ITVJ?
BALL-1 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7qTWM2OD1zND60OlY2KM7:TR?= NXTm[Xp5W0GQR1XS
LS-1034 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHHTWM2OD1zND62NVUzKM7:TR?= NHrVS5RUSU6JRWK=
U-118-MG M3rnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHsN|NKSzVyPUG0MlY{OSEQvF2= NIfY[IdUSU6JRWK=
NCI-H630 M4DOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\nRmlEPTB;MUSuOlU3QCEQvF2= MUDTRW5ITVJ?
OVCAR-8 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfTTWM2OD1zND63NlAyKM7:TR?= MkjBV2FPT0WU
NCI-H2347 MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\JfWlEPTB;MUSuPFI{KM7:TR?= NV\DXVFoW0GQR1XS
BT-549 NX73d45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\QTWM2OD1zND64Nlg1KM7:TR?= NEXadmpUSU6JRWK=
LB831-BLC MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHraUXpKSzVyPUG0Mlg6OzRizszN MYPTRW5ITVJ?
NCI-H661 NFT3S4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq1OHVoUUN3ME2xOE46PTlizszN M{P2[HNCVkeHUh?=
MKN7 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF3LkCwPVMh|ryP M1jUbnNCVkeHUh?=
U-87-MG MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO1TWM2OD1zNT6wPFk4KM7:TR?= MXPTRW5ITVJ?
OVCAR-4 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TTPWlEPTB;MUWuNVQzPCEQvF2= MWjTRW5ITVJ?
OE33 NITtWWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHYTVZ4UUN3ME2xOU4yPzFzIN88US=> MUPTRW5ITVJ?
EC-GI-10 NF3J[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF3LkKzOVch|ryP NIK2RZFUSU6JRWK=
AM-38 M1jmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF3LkK3NVch|ryP M4\UbXNCVkeHUh?=
NCI-H1563 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF3LkO0PUDPxE1? NXzxcppoW0GQR1XS
SCC-4 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfVNVlKSzVyPUG1MlQyODNizszN NEPLSWNUSU6JRWK=
Detroit562 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHtbnpKSzVyPUG1MlQ2PDdizszN Mn3wV2FPT0WU
PC-14 NEHyPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV64NWZtUUN3ME2xOU41QDZ4IN88US=> NFnCWXBUSU6JRWK=
ES3 M2jxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUizXI5yUUN3ME2xOU42OzZizszN MUjTRW5ITVJ?
OCI-AML2 NXzORnJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfWR5Y6UUN3ME2xOU44PjF2IN88US=> MYnTRW5ITVJ?
LU-134-A NYnMb2tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXNNIlYUUN3ME2xOU46ODF6IN88US=> M33kOHNCVkeHUh?=
SAS M4W2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTIOVl2UUN3ME2xOU46Ozd|IN88US=> MmDYV2FPT0WU
TGBC11TKB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF3Lkm0NVQh|ryP M4jLdXNCVkeHUh?=
HOP-62 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF3Lkm1PVch|ryP NHjlcVBUSU6JRWK=
G-401 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTQTWM2OD1zNT65OlQ6KM7:TR?= M2L2NXNCVkeHUh?=
NCI-H28 NUi4NVY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37rNWlEPTB;MU[uNFg2PiEQvF2= NV7kcoRiW0GQR1XS
A204 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\ETWM2OD1zNj6yNFA3KM7:TR?= MW\TRW5ITVJ?
NCI-H1299 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PsNGlEPTB;MU[uNlI6OSEQvF2= NIrodpBUSU6JRWK=
VMRC-RCZ NI\RWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n1eWlEPTB;MU[uNlU6OiEQvF2= NIDBRnJUSU6JRWK=
BxPC-3 NX\DOIlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rVdGlEPTB;MU[uNlg2PiEQvF2= NYXaT5RsW0GQR1XS
NCI-H2228 NVLvZXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDsb416UUN3ME2xOk42OTV6IN88US=> M2fVVHNCVkeHUh?=
NCI-H23 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLyZnZKSzVyPUG2MlYxPzhizszN NGG1XFZUSU6JRWK=
NKM-1 M{ThcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjCNG5KSzVyPUG3MlAyQDlizszN M4\obnNCVkeHUh?=
KYSE-70 NIjYZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF5LkK4PUDPxE1? MX;TRW5ITVJ?
BB49-HNC M2nscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TVUmlEPTB;MUeuOVY5PiEQvF2= NIXjbHFUSU6JRWK=
SCC-15 NIPoS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MleyTWM2OD1zNz64OFc{KM7:TR?= Ml;3V2FPT0WU
D-247MG MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF5LkmyOFch|ryP M{[5O3NCVkeHUh?=
BB30-HNC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\QTWM2OD1zOD6wN|E5KM7:TR?= MoizV2FPT0WU
CAL-85-1 M13CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XXWmlEPTB;MUiuNVgxQSEQvF2= MnLSV2FPT0WU
HT-3 NHX3ZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF6LkO5O|ch|ryP MmTrV2FPT0WU
KYSE-410 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rFfGlEPTB;MUiuOFU4PyEQvF2= MmCwV2FPT0WU
SW982 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3heG9KSzVyPUG4MlU3PDlizszN M4TRVnNCVkeHUh?=
SW962 M3vkPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVribpVVUUN3ME2xPE42PzB{IN88US=> MnXxV2FPT0WU
Ramos-2G6-4C10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq4U2dKSzVyPUG4MlU6OjdizszN NGrhU4dUSU6JRWK=
OC-314 NEXSU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;oRoNKSzVyPUG4Mlc{QDRizszN M1f5UnNCVkeHUh?=
LS-123 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPLNGcyUUN3ME2xPE44QTBzIN88US=> M4KwOnNCVkeHUh?=
D-502MG MkXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[1UGlEPTB;MUiuPFE{QSEQvF2= MUTTRW5ITVJ?
RO82-W-1 M4HQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILWdmtKSzVyPUG4MlgzQDhizszN MY\TRW5ITVJ?
HuO9 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF7LkGzO|kh|ryP M1X0b3NCVkeHUh?=
ETK-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInRbGxKSzVyPUG5MlE5OjdizszN NEjtVXZUSU6JRWK=
SNU-387 MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\kemlEPTB;MUmuNVg5QSEQvF2= NFzCR|FUSU6JRWK=
SW1573 M4\acWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLLOoRKSzVyPUG5MlE6PjlizszN M37yWXNCVkeHUh?=
NTERA-S-cl-D1 M4rCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLDTWM2OD1zOT6yNFA4KM7:TR?= NY\PbWNEW0GQR1XS
SF126 NHW4TFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LzdGlEPTB;MUmuN|UxOiEQvF2= MWfTRW5ITVJ?
Calu-3 NInaU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF7LkSyN|ch|ryP NVfKZ5dpW0GQR1XS
NCI-H1048 MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj5TWM2OD1{MD6zNlY3KM7:TR?= MUHTRW5ITVJ?
NCI-H226 M4P1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPF[JBrUUN3ME2yNE41Ozl7IN88US=> M3jLOXNCVkeHUh?=
FTC-133 NWe4b2VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn75TWM2OD1{MD60O|A{KM7:TR?= NH3m[pFUSU6JRWK=
SF539 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPDTWM2OD1{MD61NVczKM7:TR?= M33UTnNCVkeHUh?=
TE-6 M33rRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJyLkiwOlch|ryP NVvtTGM5W0GQR1XS
UMC-11 M2XZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PaTWlEPTB;MkCuPVE3PCEQvF2= M1THc3NCVkeHUh?=
Becker Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nXR2lEPTB;MkGuNVEyQCEQvF2= Ml;GV2FPT0WU
KP-4 NGjmU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG2TWM2OD1{MT6xNVk3KM7:TR?= NFzKVJdUSU6JRWK=
ChaGo-K-1 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJzLkO2Nlch|ryP NUHiRWJDW0GQR1XS
CFPAC-1 M4nFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf0ZWU2UUN3ME2yNU4{QDV6IN88US=> NYHadGRQW0GQR1XS
A498 M1KxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJzLkWzNVIh|ryP NHvRbXhUSU6JRWK=
NCI-H1755 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXrTWM2OD1{MT62O|QyKM7:TR?= MmPzV2FPT0WU
TI-73 NFHHRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fhcGlEPTB;MkKuN|I5KM7:TR?= MWDTRW5ITVJ?
NCI-H441 NV;HRWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfFWIZKSzVyPUKyMlU3QDlizszN MmfjV2FPT0WU
CaR-1 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknBTWM2OD1{Mz6wNlE{KM7:TR?= Mnz5V2FPT0WU
HCC1806 NWfyb4ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ|LkC1PFMh|ryP MYfTRW5ITVJ?
SNU-449 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvpTWdKSzVyPUKzMlMzQSEQvF2= MVfTRW5ITVJ?
EKVX M4Tzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;mTmdvUUN3ME2yN{4{QTB7IN88US=> M33vZ3NCVkeHUh?=
DMS-114 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3VTWM2OD1{Mz61O|Y2KM7:TR?= MoH0V2FPT0WU
A704 NF;ZVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj6TWM2OD1{Mz62NVA{KM7:TR?= MnLZV2FPT0WU
LC-2-ad MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPTTWM2OD1{Mz62NVQ4KM7:TR?= NHvjfXRUSU6JRWK=
VM-CUB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\4NZFKSzVyPUKzMlc{PDFizszN M3iycnNCVkeHUh?=
PC-3 M4\MUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ2LkC1NlYh|ryP MkXRV2FPT0WU
HEL NXHKVJROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJ2LkC4OlUh|ryP MUTTRW5ITVJ?
ABC-1 NHjncoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDnfGMxUUN3ME2yOE4zPzJ7IN88US=> NGrYVGlUSU6JRWK=
COLO-680N NWW0TXhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ2LkS3OlQh|ryP NFPGOGxUSU6JRWK=
MZ1-PC Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ2Lk[4O{DPxE1? NVvsNWZmW0GQR1XS
NCI-H69 NYXTd|ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jlTmlEPTB;MkSuO|M2PCEQvF2= M13BSHNCVkeHUh?=
TE-1 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHryc|JKSzVyPUK1MlA1QTlizszN NXzvOpFEW0GQR1XS
EW-3 M{C0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL6PFZxUUN3ME2yOU4yOTNizszN Mm\kV2FPT0WU
PANC-08-13 M{LOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OzPWlEPTB;MkWuPFExOyEQvF2= MYLTRW5ITVJ?
NMC-G1 NVnEeXZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3TTWM2OD1{Nj6wNFg5KM7:TR?= M17EfHNCVkeHUh?=
BT-20 NVX0RYhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHCU4VOUUN3ME2yOk41PTR|IN88US=> NYPZXGVZW0GQR1XS
TGBC24TKB NFjWPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX22XYhyUUN3ME2yOk44OzNzIN88US=> MWLTRW5ITVJ?
TE-11 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\1OYpqUUN3ME2yOk46QDl3IN88US=> MmXPV2FPT0WU
ESS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLGdpNMUUN3ME2yO{4{OjF4IN88US=> NF31c4NUSU6JRWK=
JVM-3 NHe4ZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PoXWlEPTB;MkeuOlQ4PSEQvF2= M3H3XnNCVkeHUh?=
C3A MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLI[FhKSzVyPUK3Mlg1QTZizszN Ml22V2FPT0WU
MDA-MB-157 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPk[FluUUN3ME2yO{45PzV|IN88US=> MVzTRW5ITVJ?
KLE M4nV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPPOZRKSzVyPUK4MlExPThizszN MkjjV2FPT0WU
ES1 NXv0coFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorUTWM2OD1{OD6xPFM5KM7:TR?= M4CyfXNCVkeHUh?=
CAL-120 NYPHVJJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\HdWlEPTB;MkiuN|k6QSEQvF2= MV\TRW5ITVJ?
NCI-N87 NH7sTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULFbYtpUUN3ME2yPE42OTB3IN88US=> M3;DPHNCVkeHUh?=
RPMI-8226 NWL5WmVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;5ZZNbUUN3ME2yPU4yQDR|IN88US=> NH7Jbm1USU6JRWK=
COR-L88 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Ed2FKSzVyPUK5MlI1OTlizszN NX\5dJk1W0GQR1XS
UACC-893 NIXZTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XVZmlEPTB;MkmuN|E{PyEQvF2= MYDTRW5ITVJ?
C8166 NFGzTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLvflVRUUN3ME2yPU46QTl4IN88US=> NUf3cGdqW0GQR1XS
J82 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnmellEUUN3ME2zNE45OTR5IN88US=> M2TRdnNCVkeHUh?=
PFSK-1 M4jkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT5TWM2OD1|MT6wOlU6KM7:TR?= NWLTOIN1W0GQR1XS
COLO-684 NI\MO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonZTWM2OD1|MT60N|c1KM7:TR?= MX7TRW5ITVJ?
CAL-72 NVriUZlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT4[FRmUUN3ME2zNU42PzJ7IN88US=> MXHTRW5ITVJ?
SNB75 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNzLki5O{DPxE1? MWTTRW5ITVJ?
MDA-MB-415 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDvVVdyUUN3ME2zNU46PzZ{IN88US=> NIPJPIFUSU6JRWK=
SiHa Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jFVWlEPTB;M{KuOFcyOSEQvF2= MVjTRW5ITVJ?
NCI-H1648 NYLlVVNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULWT|ZCUUN3ME2zNk46OzR3IN88US=> M1\4THNCVkeHUh?=
EFO-21 M{Llb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHTWZdKSzVyPUOzMlAxPSEQvF2= MV;TRW5ITVJ?
HCC38 NWLiPFdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTN|LkO4OFEh|ryP M2m1XXNCVkeHUh?=
IA-LM MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSwTWM2OD1|Mz63PFg6KM7:TR?= NV[5ZpBTW0GQR1XS
CTV-1 NEnG[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPLTWM2OD1|Mz65O|g3KM7:TR?= MWTTRW5ITVJ?
NCI-H446 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLnTWM2OD1|ND6yOlg6KM7:TR?= MWnTRW5ITVJ?
IST-SL1 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPwTWM2OD1|ND63OFA5KM7:TR?= MYrTRW5ITVJ?
EW-22 M{fsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr5Zo5KSzVyPUO0Mlc4PTlizszN MXfTRW5ITVJ?
JEG-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LqSmlEPTB;M{[uNVc3PiEQvF2= MVTTRW5ITVJ?
LU-65 NWHSeXlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m1OmlEPTB;M{[uNlk5PSEQvF2= MoftV2FPT0WU
NCI-H596 NWjL[plsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTN4Lkm1PVEh|ryP NFu4UlNUSU6JRWK=
KNS-81-FD NUWzb2RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTN5LkG0OUDPxE1? MVPTRW5ITVJ?
NCI-H1793 NUnB[ndCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HnemlEPTB;M{euO|A5PiEQvF2= NV20SmtmW0GQR1XS
NCI-H460 NHLOXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKySHpEUUN3ME2zPE4xQDd|IN88US=> NGn5NW5USU6JRWK=
MPP-89 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\vbWlEPTB;M{muOVg5PiEQvF2= Mn;mV2FPT0WU
D-542MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjGd|d1UUN3ME2zPU45PDN4IN88US=> M2X0OHNCVkeHUh?=
JAR MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7YTWM2OD12MD60O|A2KM7:TR?= NI\VbGtUSU6JRWK=
NCI-H209 NUjH[nV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTvdG5FUUN3ME20NE43PzdizszN MmLTV2FPT0WU
G-402 NIPPcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vJcWlEPTB;NEGuN|k6OyEQvF2= M4TvR3NCVkeHUh?=
IST-MES1 M4nyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLSTWM2OD12Mj6xPVM2KM7:TR?= Mki5V2FPT0WU
Daoy M4TJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR{LkW0O|Eh|ryP NE\aV2xUSU6JRWK=
EW-11 NGK1WFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;5TWM2OD12Mz6xNlEyKM7:TR?= M1TaXHNCVkeHUh?=
Saos-2 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqyeXlbUUN3ME20N{4yPTN5IN88US=> NYTNXFRFW0GQR1XS
no-10 NEHvVIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTR|LkG3NFIh|ryP NXLrRXgzW0GQR1XS
HCC1395 NHHoZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rWZ2lEPTB;NEOuOFY1PCEQvF2= NV64dGZ{W0GQR1XS
HCE-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nSSWlEPTB;NEOuO|Y3PCEQvF2= NWj2RmNtW0GQR1XS
EW-1 M2\jN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfsTWM2OD12Mz64NFQ6KM7:TR?= MWnTRW5ITVJ?
OCUB-M NFLwRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR2LkO2N|gh|ryP MoLTV2FPT0WU
IGR-1 NYLRdZl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS2TWM2OD12ND60NVE2KM7:TR?= M37VV3NCVkeHUh?=
NCI-H1838 NFjzcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrYbVRDUUN3ME20OE41OzR7IN88US=> MWPTRW5ITVJ?
NCI-H2405 NIOwd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTR2LkWzOEDPxE1? NYPsdohCW0GQR1XS
GB-1 NGLpb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTR2Lke0OlMh|ryP MWTTRW5ITVJ?
MG-63 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX5dHpJUUN3ME20Ok4xPjl4IN88US=> MWXTRW5ITVJ?
KP-N-YN MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;w[nRKSzVyPUS2MlQ3PzlizszN Mkn4V2FPT0WU
no-11 M4HXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPvbG1oUUN3ME20O{4xOjR2IN88US=> MWTTRW5ITVJ?
SW948 NFTPbWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTkSItKSzVyPUS3MlM{PzdizszN M{nKe3NCVkeHUh?=
CAMA-1 NWnkc|JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrMR5BKSzVyPUS3MlM1OzhizszN M3nWWXNCVkeHUh?=
HCC1187 NV;3eG5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn35TWM2OD12Nz61NUDPxE1? NUnI[296W0GQR1XS
D-392MG M2PXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XQbmlEPTB;NEeuOlUyPiEQvF2= M4S1Z3NCVkeHUh?=
647-V MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3HN2ZKSzVyPUS5MlM1OTRizszN MmXWV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK1/2 / ERK1/2 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK1/2 in sympathetic neurons. Immunoblots were performed with whole cell extracts from sympathetic neurons maintained in the presence of NGF and left untreated or treated with PD184352 at 0.1, 1, 2 or 10 μM for 16 hours. Antibodies to detect total ERK1/2 and phospho-ERK1/2 were used. 

p-ERK5 / ERK5 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK5 in sympathetic neurons.

21762482
Growth inhibition assay
Cell viability; 

PubMed: 29989268     


Relative viability of DU145CR cells treated with PD184352 was significantly less than that of DU145 cells in WST assay. 

29989268
In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

- Collapse

MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

- Collapse
  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

- Collapse
  • Animal Models: PTC cells in athymic mice
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A
Smiles FC1=CC=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Related MEK Products

Tags: buy PD184352 (CI-1040) | PD184352 (CI-1040) supplier | purchase PD184352 (CI-1040) | PD184352 (CI-1040) cost | PD184352 (CI-1040) manufacturer | order PD184352 (CI-1040) | PD184352 (CI-1040) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID