PD184352 (CI-1040)

Catalog No.S1020

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 70 In stock
USD 120 In stock
USD 270 In stock
USD 670 In stock
USD 770 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 78 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 M{DUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzVUmxtUUN3ME2wMlAzOjd4IN88US=> NI\QbopUSU6JRWK=
CHP-212 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEK4PFUh|ryP MV7TRW5ITVJ?
EoL-1-cell MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMESxOVIh|ryP MX\TRW5ITVJ?
DU-4475 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;LV4hKSzVyPUCuNFc2QTlizszN MmG3V2FPT0WU
MMAC-SF NYSyfJpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnxTWM2OD1yLkGwPVc1KM7:TR?= NEi5VZVUSU6JRWK=
AGS NH\HUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrTTWM2OD1yLkGxO|E{KM7:TR?= NVXUUXczW0GQR1XS
M14 Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUW0Olgh|ryP MnLWV2FPT0WU
CP50-MEL-B MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3GTWM2OD1yLkG3NlU1KM7:TR?= NWDOdJRwW0GQR1XS
C32 MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3NTWM2OD1yLkG5NFczKM7:TR?= NV7DOVFGW0GQR1XS
KMOE-2 NV;QdGVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC4TWM2OD1yLkG5O|k2KM7:TR?= MnvxV2FPT0WU
A101D NYXJd2xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny2TWM2OD1yLkKxOEDPxE1? M1y1TnNCVkeHUh?=
KM12 M3L6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfVepk3UUN3ME2wMlI1ODV5IN88US=> MmPPV2FPT0WU
HSC-4 NWPtN4N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HudmlEPTB;MD6yOFM6PSEQvF2= M{GzTHNCVkeHUh?=
NOMO-1 M3P1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELxZYRKSzVyPUCuNlU4PDJizszN NEXFWJpUSU6JRWK=
MZ7-mel MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\XVGw4UUN3ME2wMlI3OzRizszN M3Ti[XNCVkeHUh?=
ACN M3j5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMk[3N|ch|ryP M{\WNXNCVkeHUh?=
MEL-HO NYPMSYU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2mzTGlEPTB;MD6yO|Y2OiEQvF2= MnGxV2FPT0WU
BHT-101 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTkTWM2OD1yLkK4OlA3KM7:TR?= NYrrd3NvW0GQR1XS
SK-MEL-28 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwM{C0NFkh|ryP MofkV2FPT0WU
KG-1 NIWwUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HmTWlEPTB;MD6zNFY3QCEQvF2= M365enNCVkeHUh?=
COLO-679 NVzh[lNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXSb|JKSzVyPUCuN|I4OiEQvF2= Mm\EV2FPT0WU
SK-MEL-24 M1zWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPBNFFKSzVyPUCuN|I5OTNizszN MXLTRW5ITVJ?
G-361 NVTTU4xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\jTWM2OD1yLkO2O|k2KM7:TR?= MXjTRW5ITVJ?
KY821 NV3PU3JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj5[JFqUUN3ME2wMlM4QTFizszN NI\He|RUSU6JRWK=
KASUMI-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULmV3czUUN3ME2wMlM6QSEQvF2= Ml\JV2FPT0WU
HL-60 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPxfWJKSzVyPUCuOFEyODdizszN NUjSSGFSW0GQR1XS
K5 NYP2SI8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;jdZpKSzVyPUCuOFMyOTdizszN NHzE[|VUSU6JRWK=
KU812 M1jvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHCbpp5UUN3ME2wMlQ2Ojl7IN88US=> NWXNZmNpW0GQR1XS
SH-4 NIjBeppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHOXVhKSzVyPUCuOFYzPTZizszN MWPTRW5ITVJ?
HTC-C3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj0TWM2OD1yLkS2OVMyKM7:TR?= M3y4b3NCVkeHUh?=
CP66-MEL M2Hpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7nSGJKSzVyPUCuOFg5ODlizszN NYXRVXpIW0GQR1XS
WM-115 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqxTINKSzVyPUCuOFkzPTdizszN MXXTRW5ITVJ?
A2780 M1rKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\GPGlEPTB;MD60PVgzOyEQvF2= MoP0V2FPT0WU
P12-ICHIKAWA NYLi[GxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDUSXhKSzVyPUCuOlEzOjFizszN NWe0dWFQW0GQR1XS
HMV-II NHfCSXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwNkS0OlUh|ryP NF7IZoxUSU6JRWK=
HT-144 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPZVI1KSzVyPUCuOlQ3PTdizszN MV3TRW5ITVJ?
LB2518-MEL NEPPfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TJV2lEPTB;MD63NVY{OiEQvF2= NFHoS|VUSU6JRWK=
NCI-SNU-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorTTWM2OD1yLke1OFM{KM7:TR?= NFHoZopUSU6JRWK=
C2BBe1 M3HNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwOEGwNlMh|ryP MXXTRW5ITVJ?
PSN1 NV\uVVdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvOTWM2OD1yLkm2NVk3KM7:TR?= NX;J[JlVW0GQR1XS
UACC-257 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwOU[0O|Mh|ryP NHnFNHpUSU6JRWK=
RVH-421 M37YfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L5bmlEPTB;MD65O|E5KM7:TR?= MnPPV2FPT0WU
GP5d NGjDfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLwcVV3UUN3ME2wMlk5OzB6IN88US=> MYfTRW5ITVJ?
TYK-nu MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjVd3hYUUN3ME2xMlA{OTd{IN88US=> M2jRNnNCVkeHUh?=
SK-N-AS NIHqPHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHUTWM2OD1zLkC3PVQ4KM7:TR?= NECyVlJUSU6JRWK=
SW620 NX7tOlBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\MTm5KSzVyPUGuNVM2OzRizszN MkO2V2FPT0WU
HuP-T4 NVnVZol5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwMUizOVkh|ryP M4TuZ3NCVkeHUh?=
A549 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF22NJhKSzVyPUGuNVk2PzZizszN MmXIV2FPT0WU
Mewo MnnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwMkCyO|Yh|ryP M1jlOHNCVkeHUh?=
ONS-76 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm2XVVHUUN3ME2xMlIzODR7IN88US=> M1:2THNCVkeHUh?=
SK-MEL-1 NHO2boxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TkOWlEPTB;MT6yN|QyQSEQvF2= NUDZS2dtW0GQR1XS
RCM-1 NET6dnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qxZ2lEPTB;MT6yOFA1PyEQvF2= MoqzV2FPT0WU
H-EMC-SS M2D0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTSeVhKSzVyPUGuNlk3ODhizszN MXXTRW5ITVJ?
NCI-H2291 NEjrbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwM{K1N|Yh|ryP NES3UHlUSU6JRWK=
SW1463 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwM{O3NlEh|ryP MXfTRW5ITVJ?
LS-411N NFHLWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrHWmFKSzVyPUGuOFA2OTdizszN MVHTRW5ITVJ?
BV-173 M3zlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHoTWM2OD1zLkS0NFE2KM7:TR?= MW\TRW5ITVJ?
LS-513 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWWWlEPTB;MT60OVE6OiEQvF2= NYnGb5pGW0GQR1XS
LoVo NEnS[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmybGdiUUN3ME2xMlQ3Ozl7IN88US=> NFfIfItUSU6JRWK=
HO-1-N-1 MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzoeoE5UUN3ME2xMlUyPjN2IN88US=> NHjqeWZUSU6JRWK=
ML-2 M4rBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwNUK4Olgh|ryP M{nSUXNCVkeHUh?=
NCI-H1437 NXvRZoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwNUWyO|Uh|ryP NWrTWpJ2W0GQR1XS
SW1116 NHPKXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjrNGFlUUN3ME2xMlU3Ozl6IN88US=> MmToV2FPT0WU
A4-Fuk Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPkNVZQUUN3ME2xMlU4ODR3IN88US=> NWXISpRbW0GQR1XS
HD-MY-Z NELyfFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DmTGlEPTB;MT61O|M4PiEQvF2= MYPTRW5ITVJ?
SK-MEL-2 NUf1R21vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFwNUe0OVkh|ryP NH3L[5pUSU6JRWK=
RT-112 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjYPFFkUUN3ME2xMlU5QTV{IN88US=> Ml\hV2FPT0WU
COLO-829 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPJb4xKSzVyPUGuOlIzOzJizszN MmjXV2FPT0WU
OVCAR-5 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWNoJKSzVyPUGuO|c3QDdizszN MXXTRW5ITVJ?
NB69 NYDPZ5BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmzUmx4UUN3ME2xMlc5PDZ7IN88US=> NIW3V|lUSU6JRWK=
NCI-H292 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXlVWVbUUN3ME2xMlg3Pjl7IN88US=> MWHTRW5ITVJ?
LOXIMVI NWXH[Gw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnLfWhiUUN3ME2xMlg6PDJ5IN88US=> MWrTRW5ITVJ?
BPH-1 NYL1TFlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH4TWM2OD1zLki5OVkyKM7:TR?= NXLmUnJzW0GQR1XS
A375 NULnTnFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XFXGlEPTB;MT64PVcyPCEQvF2= NXrPZ29pW0GQR1XS
LCLC-97TM1 M3fk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwOUKyOVYh|ryP NXL3fJdoW0GQR1XS
RXF393 M3L3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu5dXRKSzVyPUGuPVc5QDdizszN NEK1SWdUSU6JRWK=
HCC70 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\3SHdKUUN3ME2yMlAzPDJ4IN88US=> NGfQNnFUSU6JRWK=
EM-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TOTmlEPTB;Mj6wO|E6QCEQvF2= NHzncnRUSU6JRWK=
MZ2-MEL MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjKTWM2OD1{LkGxNVI4KM7:TR?= NITXbYpUSU6JRWK=
HN M4rEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjnS3B{UUN3ME2yMlE3Ojd6IN88US=> Mn74V2FPT0WU
A2058 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLufGNKSzVyPUKuNVkzPzlizszN NFroNlRUSU6JRWK=
NB7 NWHGbWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwM{SwPFYh|ryP MYLTRW5ITVJ?
DOK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i0W2lEPTB;Mj6zOVc4OyEQvF2= MUDTRW5ITVJ?
CAL-27 MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH6N3hKSzVyPUKuN|kzOzZizszN MWXTRW5ITVJ?
BB65-RCC M4HXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jDd2lEPTB;Mj60NFY4PCEQvF2= MlPEV2FPT0WU
RD MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofvTWM2OD1{LkS0O|I{KM7:TR?= M{HxN3NCVkeHUh?=
KNS-62 Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL2TWM2OD1{LkWxNVY1KM7:TR?= MUnTRW5ITVJ?
EW-13 M4f1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfMTWM2OD1{LkW2N|M6KM7:TR?= NEixW3VUSU6JRWK=
DB NXziUoRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHoepFKSzVyPUKuOVg4QDhizszN M1zRXXNCVkeHUh?=
HCC2218 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\ESJZoUUN3ME2yMlY1Pzd6IN88US=> NHXRRplUSU6JRWK=
L-363 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJTWM2OD1{Lke0N|ch|ryP NFnGeJBUSU6JRWK=
CHL-1 MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwOEC3PFUh|ryP NWr6ZlBkW0GQR1XS
BFTC-905 M3W2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuyTWM2OD1{LkiyOVMh|ryP NV72[49JW0GQR1XS
HCE-T NFnXeVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;mXFc5UUN3ME2yMlg{OjZ2IN88US=> MUXTRW5ITVJ?
COLO-792 NVy0NWpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\XT5BwUUN3ME2yMlg1ODJ5IN88US=> MlfzV2FPT0WU
LB2241-RCC NFryfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PRXGlEPTB;Mj64OVg6OyEQvF2= NHHISlFUSU6JRWK=
CAL-39 NFmyeopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwOEm5PVkh|ryP M4LseXNCVkeHUh?=
T-24 NXm1TFgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJwOUGxNVIh|ryP Mmr0V2FPT0WU
NCI-H727 NXrveGJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwOUG3PVYh|ryP M1z4VnNCVkeHUh?=
Ca9-22 M3rpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnRTWM2OD1{Lkm3NlU2KM7:TR?= MUHTRW5ITVJ?
MIA-PaCa-2 NXrVVZhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfKU4pKSzVyPUOuNFA4QDFizszN Mnq1V2FPT0WU
HT-1080 NF\vN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\DbGlEPTB;Mz6wNVk6PyEQvF2= MlSxV2FPT0WU
D-423MG M2GxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvxbIlqUUN3ME2zMlA4PzV|IN88US=> MkDaV2FPT0WU
LAMA-84 NYTMT2tMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK5TWM2OD1|LkGzOVgh|ryP Mlr4V2FPT0WU
SW780 M3zYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LBe2lEPTB;Mz6xOFIzQSEQvF2= M4PJUHNCVkeHUh?=
KU-19-19 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljtTWM2OD1|LkG3NFM1KM7:TR?= Mlr3V2FPT0WU
COLO-741 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPue3RKSzVyPUOuNVg3PzNizszN M3S2e3NCVkeHUh?=
HSC-3 NWm2OXhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESwdlVKSzVyPUOuNlMyPTFizszN Mm\5V2FPT0WU
SN12C Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W2ZmlEPTB;Mz6yOFcxOSEQvF2= NFPUVIZUSU6JRWK=
786-0 M1jmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M330[2lEPTB;Mz6yO|I1OyEQvF2= NFzwXlRUSU6JRWK=
GAK MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[yNnpKSzVyPUOuN|I2PjFizszN M365S3NCVkeHUh?=
PANC-03-27 NVSxVoZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnaeIRFUUN3ME2zMlM2ODR3IN88US=> M3vZW3NCVkeHUh?=
CTB-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwNEewOFch|ryP MkD3V2FPT0WU
A427 NU\qZ3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LIPWlEPTB;Mz61PVU2PiEQvF2= NHv6TVBUSU6JRWK=
EGI-1 NYnYXnJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTNwNkC1PFMh|ryP NY[3XIpsW0GQR1XS
U-2-OS M2\Z[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwNkeyOVYh|ryP M3HJ[XNCVkeHUh?=
NCI-SNU-5 M2TZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNwNke3N{DPxE1? NXS4cXdyW0GQR1XS
SK-LU-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj3TWM2OD1|Lk[4O|k5KM7:TR?= NWrQZXpLW0GQR1XS
697 M1\OWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSze|R6UUN3ME2zMlY6PjB|IN88US=> NXvsTIpEW0GQR1XS
HPAF-II MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnCb4hKSzVyPUOuO|U1QSEQvF2= NIPwc4ZUSU6JRWK=
NCI-H2087 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfCTWM2OD1|Lki0OlczKM7:TR?= M3\qOHNCVkeHUh?=
SK-MEL-3 NWnrV2tCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fufGlEPTB;Mz64OVE2PCEQvF2= MYnTRW5ITVJ?
CGTH-W-1 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnuPYtJUUN3ME2zMlg2PzJ3IN88US=> NIHDXpBUSU6JRWK=
8505C MlrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\OZWlEPTB;Mz65NFA4QCEQvF2= M{\v[XNCVkeHUh?=
GAMG M{fOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDt[4hKSzVyPUSuNFI{PzdizszN NFzK[GxUSU6JRWK=
SW626 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHxTWM2OD12LkC0OFgh|ryP NE\5SJhUSU6JRWK=
CAL-62 M4[xNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRwMEe0N{DPxE1? M2TGTnNCVkeHUh?=
MHH-PREB-1 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTRwMUKxNVEh|ryP NXfTXnFKW0GQR1XS
RPMI-7951 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TyWWlEPTB;ND6yOVU5QSEQvF2= MWDTRW5ITVJ?
HOP-92 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT3WYpKSzVyPUSuNlU3PyEQvF2= MXPTRW5ITVJ?
MDA-MB-231 NGGxNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHkU4ZKSzVyPUSuNlkzOjNizszN NEXKenZUSU6JRWK=
LAN-6 M2TsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTRwM{G2N|ch|ryP NWH1SllZW0GQR1XS
ALL-PO NI\3e4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nEPGlEPTB;ND6zOlE2PiEQvF2= MXjTRW5ITVJ?
HH NG[xXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDyPHhtUUN3ME20MlQyPTl5IN88US=> NWXsVZF1W0GQR1XS
IGROV-1 NFnPU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnBc2VPUUN3ME20MlQ2OTdzIN88US=> Mo\WV2FPT0WU
NCI-H358 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwNEWzPFUh|ryP M4XIU3NCVkeHUh?=
NB5 M2jmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PpOmlEPTB;ND62NFM3QSEQvF2= M37xe3NCVkeHUh?=
NCI-H747 M{HMVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTRwNki4NFch|ryP NGHBUXJUSU6JRWK=
NH-12 NWTsTFBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvFVXZ6UUN3ME20MlcyPjJ3IN88US=> NH[yRY5USU6JRWK=
LB1047-RCC M1nkNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLZOphlUUN3ME20Mlc{QDF3IN88US=> NV72dJhTW0GQR1XS
EFO-27 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXWcGtKSzVyPUSuO|g3PjdizszN NXXV[pNRW0GQR1XS
EPLC-272H NXzZemVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6SmlEPTB;ND65PVY3QSEQvF2= M{DIbXNCVkeHUh?=
CAL-54 M{TjWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rKcmlEPTB;NT6wNlY6PSEQvF2= M{j0fHNCVkeHUh?=
H4 M1vUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPLSnNbUUN3ME21MlA1OjV3IN88US=> NXHY[2xFW0GQR1XS
MOLT-13 MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX5TWM2OD13LkC2O|c3KM7:TR?= NFrEcplUSU6JRWK=
CAL-33 M{TSXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjxPJFbUUN3ME21MlEzOzF5IN88US=> M{TleHNCVkeHUh?=
23132-87 M3;6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorXTWM2OD13LkG2PFczKM7:TR?= MmKwV2FPT0WU
UM-UC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr2OnRKSzVyPUWuNVgxPDdizszN NWTVXVlXW0GQR1XS
HuH-7 M2DTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XXRWlEPTB;NT6yO|E1PyEQvF2= NHzLUHdUSU6JRWK=
BCPAP MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTVwM{K5Olkh|ryP NYT1PVByW0GQR1XS
AsPC-1 NITuPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\NcWlEPTB;NT6zOlc3OyEQvF2= M3G3NXNCVkeHUh?=
NCI-H1155 NYSxUpd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDKTWM2OD13LkSwNFUyKM7:TR?= M2\SUXNCVkeHUh?=
GT3TKB M2DhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTVwNE[1PVgh|ryP NF7kZ5FUSU6JRWK=
HCC2998 M1u5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XtNWlEPTB;NT60PVExQSEQvF2= NFfHW5FUSU6JRWK=
NUGC-3 NGPQc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3OUFI3UUN3ME21MlQ6OzB{IN88US=> NIm5WWZUSU6JRWK=
Hs-578-T MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[xTWM2OD13LkWzO|k1KM7:TR?= MUHTRW5ITVJ?
FADU MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTVwNUW3NlYh|ryP NIniSFJUSU6JRWK=
NBsusSR MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTVwNUexOVUh|ryP NX\3R3d6W0GQR1XS
ME-180 NELjXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfsZm1KSzVyPUWuOVgxQTJizszN NGH4d4dUSU6JRWK=
SW1710 NYq2SnRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rFVWlEPTB;NT62NVY2PCEQvF2= M1[2dXNCVkeHUh?=
HuP-T3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTVwNkKwNlkh|ryP MmftV2FPT0WU
HOS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTVwNkK5NlMh|ryP MUPTRW5ITVJ?
PA-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr6WIlPUUN3ME21MlY1OjZ3IN88US=> NF\lO2pUSU6JRWK=
LU-99A Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTVwNk[0OVEh|ryP NWTpRWtTW0GQR1XS
RS4-11 M4HIcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHoTWM2OD13Lk[2O|c2KM7:TR?= M1L0TXNCVkeHUh?=
TE-8 NF7KV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD5R5BZUUN3ME21MlY5PTN5IN88US=> NYS3XnFxW0GQR1XS
RERF-LC-MS MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnGSYVKSzVyPUWuOlg5ODNizszN NVjsUlJ5W0GQR1XS
MEL-JUSO M4fMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTVwN{O3PEDPxE1? M3PTfXNCVkeHUh?=
SK-MES-1 NG[0OY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1SYdKSzVyPUWuPFM2OjhizszN MV7TRW5ITVJ?
D-263MG MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTVwOEizOVEh|ryP NY\vNZdvW0GQR1XS
NB10 NI\0eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHuTWM2OD13Lki5OFYh|ryP Ml3rV2FPT0WU
SK-HEP-1 M1fXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13r[mlEPTB;NT65N|Q4OSEQvF2= M4DMRXNCVkeHUh?=
HT-29 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO0VmtKSzVyPUWuPVgyOThizszN NVfUNIxmW0GQR1XS
KYSE-140 M4X3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTXVHNqUUN3ME22MlAzOTh{IN88US=> MV\TRW5ITVJ?
NCI-H1666 M1nBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXKyUpBWUUN3ME22MlA5PDZzIN88US=> Mlu2V2FPT0WU
NCI-H1304 M2TNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZwMUm5OEDPxE1? MX3TRW5ITVJ?
RPMI-8866 NGjodmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHWRnFKSzVyPU[uNlE{OTNizszN M1LrSXNCVkeHUh?=
MV-4-11 MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny1TWM2OD14LkKzNVk6KM7:TR?= NUTySFFoW0GQR1XS
A431 M{XsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H1RmlEPTB;Nj6yOFI6PiEQvF2= MXrTRW5ITVJ?
PANC-10-05 M4nCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nrPGlEPTB;Nj6yPFM3OyEQvF2= MUjTRW5ITVJ?
TK10 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr2e5dlUUN3ME22MlMzPjB2IN88US=> NWq4TnB2W0GQR1XS
NCI-H1975 NX30VYVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTZwNEeyNVUh|ryP MUfTRW5ITVJ?
A172 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTZwNEmxO|Yh|ryP NHn1fZBUSU6JRWK=
D-566MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7kNXJKSzVyPU[uOVQ{ODNizszN NVLvUZBxW0GQR1XS
NCI-H2122 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jkcWlEPTB;Nj62NVUzQCEQvF2= NHXhem1USU6JRWK=
COR-L105 MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTZwNkWyO|Uh|ryP NUXKR4psW0GQR1XS
AN3-CA NUTIZmhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGz[GFKSzVyPU[uOlg3PDFizszN NFizSIxUSU6JRWK=
Calu-6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7xTJM2UUN3ME22Mlc6Pjl6IN88US=> MYHTRW5ITVJ?
HCT-116 NH7KUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XEcGlEPTB;Nj64NVI3PCEQvF2= MojoV2FPT0WU
MHH-NB-11 NH[0WnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLvTWM2OD14Lki1NFAzKM7:TR?= NGfjPY1USU6JRWK=
MFE-280 NF64cXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTZwOEW5PFMh|ryP MYPTRW5ITVJ?
SW1088 M1vuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPqTWM2OD14LkmxPVE{KM7:TR?= NX71WZVEW0GQR1XS
SW48 NXX2THV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTZwOUS1NUDPxE1? NHfTPGJUSU6JRWK=
HuCCT1 M33rfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHrSHlKSzVyPUeuNFExOzdizszN MXPTRW5ITVJ?
ACHN MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\CTWM2OD15LkCyPVQ{KM7:TR?= NGXvXlVUSU6JRWK=
8305C M4flUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETjRVRKSzVyPUeuNFk6QTVizszN NVzwPHJrW0GQR1XS
DoTc2-4510 M2jkbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XxN2lEPTB;Nz6xNlE2KM7:TR?= M3n2T3NCVkeHUh?=
COR-L23 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;STWM2OD15LkK0OFIh|ryP MmHnV2FPT0WU
SK-MEL-30 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHaTWM2OD15LkK1NFg{KM7:TR?= MWPTRW5ITVJ?
BE-13 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3oTZFvUUN3ME23MlM{QDN2IN88US=> NID0TGdUSU6JRWK=
GR-ST MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTdwNECxO|Qh|ryP NHTZSmpUSU6JRWK=
LU-135 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PE[WlEPTB;Nz61OVk{QSEQvF2= NEPORWFUSU6JRWK=
U-266 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTdwNU[yPFYh|ryP M1\weHNCVkeHUh?=
NCI-H1355 MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuwNFg5UUN3ME23MlU5PjN3IN88US=> M3yzcnNCVkeHUh?=
NB14 NUP4NXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrxRpBKSzVyPUeuOlY3PDJizszN MWTTRW5ITVJ?
SCC-25 MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTdwN{C5JO69VQ>? NIe2bmNUSU6JRWK=
COLO-678 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTdwN{GwO|Yh|ryP M1fKcXNCVkeHUh?=
TGBC1TKB M{LmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jtVWlEPTB;Nz64PVM6QCEQvF2= NWLmTYhbW0GQR1XS
IST-MEL1 M{S4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRThwMEC0NFYh|ryP Mm\6V2FPT0WU
ECC10 NHnsTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfCTWM2OD16LkCzN|k2KM7:TR?= NXjmWVFYW0GQR1XS
EW-16 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW5TWM2OD16LkC4OFQ2KM7:TR?= MXHTRW5ITVJ?
DOHH-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7BTWM2OD16LkKwNFk2KM7:TR?= NWTB[2REW0GQR1XS
NCI-H1581 M4HWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPxTnpKSzVyPUiuNlY{OjNizszN MULTRW5ITVJ?
TE-5 M3PuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljBTWM2OD16LkSyOFI6KM7:TR?= MX;TRW5ITVJ?
CAKI-1 M1vSNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fIVmlEPTB;OD61O|IzOiEQvF2= NEHDfVlUSU6JRWK=
A673 M3nlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRThwNkOyNFIh|ryP MVrTRW5ITVJ?
CAL-12T NX3MUZIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHPVGJKSzVyPUiuOlU4PTNizszN M2ruSnNCVkeHUh?=
DBTRG-05MG NHW3VIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRThwN{S4OVkh|ryP MlvwV2FPT0WU
SK-N-FI NI\qcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HlNGlEPTB;OD64NVM4QSEQvF2= NFjGbINUSU6JRWK=
K-562 M{jVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRThwOEO5OVch|ryP MWHTRW5ITVJ?
SBC-1 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXFbXpKSzVyPUiuPFY3PDVizszN MoLRV2FPT0WU
ES4 NY\jT5BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3rbpJKSzVyPUiuPFY5QDRizszN MULTRW5ITVJ?
MS-1 NED4ZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjTUFFVUUN3ME24Mlg4PTF5IN88US=> NHjOdZVUSU6JRWK=
RKO NFHkOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRThwOEmwOVch|ryP M3KzUnNCVkeHUh?=
NCI-H1693 M{TOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PQT2lEPTB;OD65NlE4KM7:TR?= NVfaTHc4W0GQR1XS
SW954 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjmRXpFUUN3ME24Mlk3QTd6IN88US=> NVHtdldiW0GQR1XS
SK-UT-1 MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETCWYxKSzVyPUiuPVc3QDNizszN MUHTRW5ITVJ?
T98G NIXzWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP0XHZ7UUN3ME24Mlk6QDR4IN88US=> M4[yOXNCVkeHUh?=
NCI-H2126 MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe1R25KSzVyPUmuNFA5OjZizszN MnnvV2FPT0WU
TE-12 NUW5bXR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEna[3NKSzVyPUmuNFM{PjdizszN MlrwV2FPT0WU
DK-MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTlwMkGxPVEh|ryP NFn5O2NUSU6JRWK=
MEG-01 NFzJfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:0[m5KSzVyPUmuNlQ6OzFizszN NHzoPYhUSU6JRWK=
HCC1937 M3SxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnJXHVbUUN3ME25MlI6ODlzIN88US=> M4XTT3NCVkeHUh?=
MKN45 NFm1UZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ZOmRKSzVyPUmuOFUxPjVizszN M1rWOHNCVkeHUh?=
NCI-H1792 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLTNHBKSzVyPUmuOFUzOTlizszN NHnYTYlUSU6JRWK=
SW1417 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r2UWlEPTB;OT61Olg{PyEQvF2= MX;TRW5ITVJ?
639-V M1X4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTlwNkSzPFgh|ryP M1PES3NCVkeHUh?=
P30-OHK NV3VfmlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\H[2lEPTB;OT62OVMyPiEQvF2= NUex[3ZwW0GQR1XS
YKG-1 NYfqOGd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7tVGpyUUN3ME25Mlc2ODN|IN88US=> NYL1bFdFW0GQR1XS
KGN NXv5eoVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HZNGlEPTB;OT64N|c6PSEQvF2= Mo[3V2FPT0WU
MSTO-211H MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTlwOUW1Nlkh|ryP NEDneYZUSU6JRWK=
NCI-H1573 NUHUN2dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrRWFBKSzVyPUGwMlE2PzRizszN M2CxUnNCVkeHUh?=
NCI-H720 NFq0ZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFyLkG5PFkh|ryP M4GwcXNCVkeHUh?=
KARPAS-45 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnXUHRVUUN3ME2xNE4zPzl3IN88US=> NVm5WYhzW0GQR1XS
MDA-MB-175-VII MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjNWWo6UUN3ME2xNE41QCEQvF2= NXm0eZo4W0GQR1XS
SK-NEP-1 NEW5N4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFyLkS5PFEh|ryP MkDJV2FPT0WU
MKN28 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzOfoVKSzVyPUGwMlUyQCEQvF2= NYTHXm5mW0GQR1XS
KYSE-520 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC3TWM2OD1zMD61NkDPxE1? MofxV2FPT0WU
KE-37 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS2PGF[UUN3ME2xNE42Ojd{IN88US=> MkTkV2FPT0WU
VA-ES-BJ M2TWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonPTWM2OD1zMD61Olch|ryP NIrXfG5USU6JRWK=
CCRF-CEM MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTFyLkW2PFQh|ryP NEf3[W1USU6JRWK=
GMS-10 NU\kVXhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQfGlEPTB;MUCuOlA6PCEQvF2= NVjsRlVlW0GQR1XS
NCI-H1623 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnryTWM2OD1zMD62N|c6KM7:TR?= NFX6[IxUSU6JRWK=
NEC8 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHFTWM2OD1zMD63O|c{KM7:TR?= M3XSRnNCVkeHUh?=
MOLT-16 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGxT2xKSzVyPUGwMlgyOTNizszN MX;TRW5ITVJ?
DJM-1 M3Lm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFzLkCzO|kh|ryP M1jDcXNCVkeHUh?=
U251 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjVPHZtUUN3ME2xNU4xPDJizszN MmjMV2FPT0WU
SBC-5 NXjoU4VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFzLkG0Olch|ryP MUDTRW5ITVJ?
SW756 NGficldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DjTWlEPTB;MUGuNlE2PCEQvF2= MmjtV2FPT0WU
KS-1 NVq5XVdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnESndKSzVyPUGxMlI3OTlizszN M2LmenNCVkeHUh?=
SF295 MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG2TWM2OD1zMT6zNVA1KM7:TR?= NGr6TGFUSU6JRWK=
YH-13 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTPZo1KSzVyPUGxMlMzPjdizszN MmPCV2FPT0WU
SW837 NX62PZZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\STWM2OD1zMT6zOVA3KM7:TR?= NIjDbJVUSU6JRWK=
KYSE-450 NVnT[|RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknFTWM2OD1zMT60NFU4KM7:TR?= NUPWfWszW0GQR1XS
KYSE-180 NEfPdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFzLkS4NkDPxE1? M4THdHNCVkeHUh?=
S-117 NGnDdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILT[lFKSzVyPUGxMlQ5QTZizszN M2jVXXNCVkeHUh?=
KOSC-2 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;PTWM2OD1zMT62NlIzKM7:TR?= NFjtPYNUSU6JRWK=
KYSE-270 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFzLki3OFUh|ryP MWXTRW5ITVJ?
D-336MG NHfUeZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFzLkmwO|Uh|ryP NFOyXYxUSU6JRWK=
KALS-1 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7LNohlUUN3ME2xNk4xODF4IN88US=> MmrnV2FPT0WU
LB373-MEL-D MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XsbmlEPTB;MUKuNFU{OyEQvF2= M2XpcXNCVkeHUh?=
HLE NEjVUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nB[GlEPTB;MUKuNFU5PSEQvF2= NWL6b4R[W0GQR1XS
SJSA-1 NUi4PZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF{LkC3N|Uh|ryP MkLGV2FPT0WU
SW1990 NUXOfINMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M370XmlEPTB;MUKuNFkyOSEQvF2= MU\TRW5ITVJ?
NOS-1 M2HJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF{LkGzOVIh|ryP NWDE[45RW0GQR1XS
GI-ME-N MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q4[WlEPTB;MUKuNlE3OyEQvF2= MkHvV2FPT0WU
NCI-H1703 MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF{LkK2NVYh|ryP MUPTRW5ITVJ?
ES7 NGXXXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[2TWM2OD1zMj6yO|I1KM7:TR?= MUPTRW5ITVJ?
KYSE-510 M{TDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPENJVQUUN3ME2xNk42ODd7IN88US=> NUDJUFc3W0GQR1XS
BHY NG\nTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF{LkWzNFch|ryP MVHTRW5ITVJ?
TCCSUP NYPWZZFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvxTWM2OD1zMj61O|U4KM7:TR?= MY\TRW5ITVJ?
HSC-2 NGL3bY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfSZWVvUUN3ME2xNk42QTl4IN88US=> NVrze|ZoW0GQR1XS
BEN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W1RmlEPTB;MUKuOlE1OyEQvF2= MX;TRW5ITVJ?
769-P MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXaV25KSzVyPUGyMlc6OjRizszN MWXTRW5ITVJ?
HT M2HVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF{LkizOFYh|ryP M3PIPXNCVkeHUh?=
LXF-289 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLnR29KSzVyPUGyMlk2OzFizszN NEjOdo5USU6JRWK=
OVCAR-3 M3j5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jaW2lEPTB;MUKuPVU3PyEQvF2= Mo\JV2FPT0WU
ATN-1 M{exSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTsTWM2OD1zMz6wNVg1KM7:TR?= M3;SUnNCVkeHUh?=
8-MG-BA NVXZNHd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjTTWM2OD1zMz6wOFU2KM7:TR?= NI\mc2NUSU6JRWK=
SW13 M4XjUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXX[oNKSzVyPUGzMlEyPjVizszN MX;TRW5ITVJ?
NCI-H1092 NV7XNJpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm0TWM2OD1zMz6xOlIh|ryP NWjpSWpPW0GQR1XS
OAW-42 M{i1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2juOWlEPTB;MUOuNVk{PyEQvF2= MWLTRW5ITVJ?
NCI-H2452 NHzYTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml75TWM2OD1zMz6yNVc2KM7:TR?= Ml[5V2FPT0WU
CAPAN-1 M16z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLvTWM2OD1zMz61OVE1KM7:TR?= M1PE[3NCVkeHUh?=
NCI-H2009 M32wcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLXTWM2OD1zMz61PVE6KM7:TR?= NUDaV3VnW0GQR1XS
SF268 M132fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF36Om1KSzVyPUGzMlY{OjZizszN MVTTRW5ITVJ?
GCIY MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITCb4dKSzVyPUGzMlY6OjdizszN NVvOU3NyW0GQR1XS
OS-RC-2 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTyeFJKSzVyPUGzMlk2ODFizszN MW\TRW5ITVJ?
GCT MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[wTWM2OD1zMz65Olk4KM7:TR?= NHr0[2dUSU6JRWK=
NB17 M3[xRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT0fJdnUUN3ME2xOE4xQDVizszN MknsV2FPT0WU
NCI-H2030 M3uzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP6NWhKSzVyPUG0MlE1PjVizszN NX\ZR49pW0GQR1XS
HC-1 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7pR3dSUUN3ME2xOE4zODh5IN88US=> MXLTRW5ITVJ?
QIMR-WIL MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfBTWM2OD1zND6zOFEzKM7:TR?= MWDTRW5ITVJ?
Capan-2 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\jW5BKSzVyPUG0MlM4OTRizszN NFzieHFUSU6JRWK=
BALL-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P1WGlEPTB;MUSuOFY3PSEQvF2= NVLtUmZqW0GQR1XS
LS-1034 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPZRmxRUUN3ME2xOE43OTV{IN88US=> MVfTRW5ITVJ?
U-118-MG M4\qdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rDe2lEPTB;MUSuOlMyKM7:TR?= NXTvNYNVW0GQR1XS
NCI-H630 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfFTWM2OD1zND62OVY5KM7:TR?= MVrTRW5ITVJ?
OVCAR-8 NXnzT2trT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvObGlKSzVyPUG0MlczODFizszN NWfkS4tzW0GQR1XS
NCI-H2347 NVruSHpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmwTWM2OD1zND64NlMh|ryP NG\MbmRUSU6JRWK=
BT-549 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDIOlVnUUN3ME2xOE45Ojh2IN88US=> NWHQToRCW0GQR1XS
LB831-BLC M2DuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF2Lki5N|Qh|ryP NXXGUlN[W0GQR1XS
NCI-H661 M3\QR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT5WlhKSzVyPUG0Mlk2QSEQvF2= MnP1V2FPT0WU
MKN7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\lXW5KSzVyPUG1MlAxQTNizszN NWDOR4R1W0GQR1XS
U-87-MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor1TWM2OD1zNT6wPFk4KM7:TR?= NHrH[pBUSU6JRWK=
OVCAR-4 MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXoTJFKSzVyPUG1MlE1OjRizszN M4fTNnNCVkeHUh?=
OE33 NX;LbGdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTUTWM2OD1zNT6xO|EyKM7:TR?= MYfTRW5ITVJ?
EC-GI-10 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS4PI85UUN3ME2xOU4zOzV5IN88US=> MlLQV2FPT0WU
AM-38 MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W0dmlEPTB;MUWuNlcyPyEQvF2= M1S1WnNCVkeHUh?=
NCI-H1563 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjTb|NKSzVyPUG1MlM1QSEQvF2= MWXTRW5ITVJ?
SCC-4 M37XTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojZTWM2OD1zNT60NVA{KM7:TR?= NWXScZdzW0GQR1XS
Detroit562 NHzMVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P5VWlEPTB;MUWuOFU1PyEQvF2= MlrJV2FPT0WU
PC-14 NFSyZohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fIOmlEPTB;MUWuOFg3PiEQvF2= NVjzXXF6W0GQR1XS
ES3 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOyZ|ZKSzVyPUG1MlU{PiEQvF2= NHLIOppUSU6JRWK=
OCI-AML2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLhZWdxUUN3ME2xOU44PjF2IN88US=> MkjtV2FPT0WU
LU-134-A MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf0TWM2OD1zNT65NFE5KM7:TR?= NF;HRXVUSU6JRWK=
SAS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHXTWM2OD1zNT65N|c{KM7:TR?= MWnTRW5ITVJ?
TGBC11TKB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofaTWM2OD1zNT65OFE1KM7:TR?= MkK0V2FPT0WU
HOP-62 NX72ZVhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;BT4ZUUUN3ME2xOU46PTl5IN88US=> MUDTRW5ITVJ?
G-401 NVXxT2dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXzUJNKSzVyPUG1Mlk3PDlizszN NV\oTFhUW0GQR1XS
NCI-H28 NUm4WnNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H2PWlEPTB;MU[uNFg2PiEQvF2= NGHaZnhUSU6JRWK=
A204 M2PWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrFVWhKSzVyPUG2MlIxODZizszN NVexemJ6W0GQR1XS
NCI-H1299 M3XpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL6TWM2OD1zNj6yNlkyKM7:TR?= Ml[zV2FPT0WU
VMRC-RCZ NYXNOmRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HmUWlEPTB;MU[uNlU6OiEQvF2= NF3BS3NUSU6JRWK=
BxPC-3 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3nTWM2OD1zNj6yPFU3KM7:TR?= MUnTRW5ITVJ?
NCI-H2228 NXvwPXozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF4LkWxOVgh|ryP MV\TRW5ITVJ?
NCI-H23 NYXH[mhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLVTWM2OD1zNj62NFc5KM7:TR?= MXPTRW5ITVJ?
NKM-1 NETsc4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnac4tKSzVyPUG3MlAyQDlizszN NFXmVXRUSU6JRWK=
KYSE-70 NILrV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET5NXFKSzVyPUG3MlI5QSEQvF2= M3zPZnNCVkeHUh?=
BB49-HNC Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXVTWM2OD1zNz61Olg3KM7:TR?= MkHXV2FPT0WU
SCC-15 M4nve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK3TWM2OD1zNz64OFc{KM7:TR?= MmnzV2FPT0WU
D-247MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XGNGlEPTB;MUeuPVI1PyEQvF2= NYHNeZg4W0GQR1XS
BB30-HNC M4HwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvtTWM2OD1zOD6wN|E5KM7:TR?= NIr5dIJUSU6JRWK=
CAL-85-1 M1XaOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLvTWM2OD1zOD6xPFA6KM7:TR?= NHfGUmJUSU6JRWK=
HT-3 NGLLc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HYc2lEPTB;MUiuN|k4PyEQvF2= M17pW3NCVkeHUh?=
KYSE-410 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfwRWJKSzVyPUG4MlQ2PzdizszN MWDTRW5ITVJ?
SW982 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LLV2lEPTB;MUiuOVY1QSEQvF2= NFjmV4RUSU6JRWK=
SW962 M1u3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3LV2Q6UUN3ME2xPE42PzB{IN88US=> MkHVV2FPT0WU
Ramos-2G6-4C10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfJbXgzUUN3ME2xPE42QTJ5IN88US=> MV;TRW5ITVJ?
OC-314 M3rBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Xud2lEPTB;MUiuO|M5PCEQvF2= NIrFSGVUSU6JRWK=
LS-123 NY\ScI12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfp[pZKSzVyPUG4Mlc6ODFizszN NWXHUmNwW0GQR1XS
D-502MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fERmlEPTB;MUiuPFE{QSEQvF2= MmXFV2FPT0WU
RO82-W-1 NUT5O|JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF6LkiyPFgh|ryP MkDEV2FPT0WU
HuO9 NWOxOVFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDJ[lR7UUN3ME2xPU4yOzd7IN88US=> NV7YS|NwW0GQR1XS
ETK-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzRfYJKSzVyPUG5MlE5OjdizszN M{SyW3NCVkeHUh?=
SNU-387 MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;tdmlEPTB;MUmuNVg5QSEQvF2= MlmyV2FPT0WU
SW1573 NUC0U|dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXaTWM2OD1zOT6xPVY6KM7:TR?= M1TkUHNCVkeHUh?=
NTERA-S-cl-D1 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqxbGFsUUN3ME2xPU4zODB5IN88US=> MnXVV2FPT0WU
SF126 NH;uc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfDbGt3UUN3ME2xPU4{PTB{IN88US=> M1XoXHNCVkeHUh?=
Calu-3 NUflO3FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLyTWM2OD1zOT60NlM4KM7:TR?= MX;TRW5ITVJ?
NCI-H1048 NUe4OIJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfKTWM2OD1{MD6zNlY3KM7:TR?= MVHTRW5ITVJ?
NCI-H226 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX30OFV3UUN3ME2yNE41Ozl7IN88US=> NWWzSW1lW0GQR1XS
FTC-133 M4rjWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rqbGlEPTB;MkCuOFcxOyEQvF2= NXnH[5F{W0GQR1XS
SF539 MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJyLkWxO|Ih|ryP MnTuV2FPT0WU
TE-6 NFnzRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHOem9KSzVyPUKwMlgxPjdizszN MWDTRW5ITVJ?
UMC-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJyLkmxOlQh|ryP Mn3hV2FPT0WU
Becker NFrNT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG2S3VKSzVyPUKxMlEyOThizszN M1rBRnNCVkeHUh?=
KP-4 NHTJSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJzLkGxPVYh|ryP NYjJ[XZqW0GQR1XS
ChaGo-K-1 NFjuNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r0N2lEPTB;MkGuN|YzPyEQvF2= MVLTRW5ITVJ?
CFPAC-1 NUH2eWh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjuTWM2OD1{MT6zPFU5KM7:TR?= NHn4Wm1USU6JRWK=
A498 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f5dGlEPTB;MkGuOVMyOiEQvF2= M3nOSXNCVkeHUh?=
NCI-H1755 NWHlPJpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfkTWM2OD1{MT62O|QyKM7:TR?= NGK2TZVUSU6JRWK=
TI-73 NYfZZnI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP5TWM2OD1{Mj6zNlgh|ryP M3HJSnNCVkeHUh?=
NCI-H441 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ{LkW2PFkh|ryP NXjyXWVYW0GQR1XS
CaR-1 NGKyWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJ|LkCyNVMh|ryP MlHKV2FPT0WU
HCC1806 MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHRSW1rUUN3ME2yN{4xPTh|IN88US=> NV;zTYhDW0GQR1XS
SNU-449 M3H6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYTWM2OD1{Mz6zNlkh|ryP MkfCV2FPT0WU
EKVX NYTEXVZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n1WWlEPTB;MkOuN|kxQSEQvF2= NVXFcnJbW0GQR1XS
DMS-114 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXUTWM2OD1{Mz61O|Y2KM7:TR?= NFfhOmlUSU6JRWK=
A704 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJ|Lk[xNFMh|ryP MYnTRW5ITVJ?
LC-2-ad MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ|Lk[xOFch|ryP M2HlTnNCVkeHUh?=
VM-CUB-1 NEjQRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJ|LkezOFEh|ryP MUnTRW5ITVJ?
PC-3 NV:5S3NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4izZmlEPTB;MkSuNFUzPiEQvF2= MlzXV2FPT0WU
HEL NGnyXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q5d2lEPTB;MkSuNFg3PSEQvF2= M1\l[3NCVkeHUh?=
ABC-1 NYfVR3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O0UGlEPTB;MkSuNlczQSEQvF2= NXzMfm82W0GQR1XS
COLO-680N M4\mTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvZSVFlUUN3ME2yOE41PzZ2IN88US=> NXjZVW5DW0GQR1XS
MZ1-PC Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[3dmlEPTB;MkSuOlg4KM7:TR?= MnzCV2FPT0WU
NCI-H69 M{DxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJ2LkezOVQh|ryP MlHCV2FPT0WU
TE-1 NHntXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHJZollUUN3ME2yOU4xPDl7IN88US=> MYjTRW5ITVJ?
EW-3 NUTaeZlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWzTWM2OD1{NT6xNVMh|ryP MYPTRW5ITVJ?
PANC-08-13 NGnEVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nDO2lEPTB;MkWuPFExOyEQvF2= MYTTRW5ITVJ?
NMC-G1 M2HKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{naWWlEPTB;Mk[uNFA5QCEQvF2= NWXhdlh4W0GQR1XS
BT-20 NHrETplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjIbnZKSzVyPUK2MlQ2PDNizszN M2HsUnNCVkeHUh?=
TGBC24TKB MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDlUJNKSzVyPUK2Mlc{OzFizszN M3\SSHNCVkeHUh?=
TE-11 Mm\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;yeXRKSzVyPUK2Mlk5QTVizszN MWjTRW5ITVJ?
ESS-1 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTPTWM2OD1{Nz6zNlE3KM7:TR?= NVrrfm9vW0GQR1XS
JVM-3 M2P5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnVWnhtUUN3ME2yO{43PDd3IN88US=> MYnTRW5ITVJ?
C3A NEDlZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7qToozUUN3ME2yO{45PDl4IN88US=> M2HsU3NCVkeHUh?=
MDA-MB-157 NW\PUlB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zRNWlEPTB;MkeuPFc2OyEQvF2= NWrt[HlIW0GQR1XS
KLE NVjDd|cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPCTWM2OD1{OD6xNFU5KM7:TR?= MXLTRW5ITVJ?
ES1 Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLtTWM2OD1{OD6xPFM5KM7:TR?= MonuV2FPT0WU
CAL-120 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7hXZBtUUN3ME2yPE4{QTl7IN88US=> NWL5SmNvW0GQR1XS
NCI-N87 NVnsTZhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXRdlBKSzVyPUK4MlUyODVizszN M1;wT3NCVkeHUh?=
RPMI-8226 MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LMcmlEPTB;MkmuNVg1OyEQvF2= M37u[3NCVkeHUh?=
COR-L88 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHSTWM2OD1{OT6yOFE6KM7:TR?= MoK5V2FPT0WU
UACC-893 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPmOG5UUUN3ME2yPU4{OTN5IN88US=> M3[0THNCVkeHUh?=
C8166 NXf1RYcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\WTWM2OD1{OT65PVk3KM7:TR?= NHXaSm1USU6JRWK=
J82 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LwdmlEPTB;M{CuPFE1PyEQvF2= Mnm5V2FPT0WU
PFSK-1 NVn3VYpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTNSI5KSzVyPUOxMlA3PTlizszN MYDTRW5ITVJ?
COLO-684 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrGTWM2OD1|MT60N|c1KM7:TR?= NVe4ZoM3W0GQR1XS
CAL-72 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjscXVyUUN3ME2zNU42PzJ7IN88US=> NYPQXYsxW0GQR1XS
SNB75 M1jLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jhVWlEPTB;M{GuPFk4KM7:TR?= NHPCR|RUSU6JRWK=
MDA-MB-415 NX;XU2RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LE[mlEPTB;M{GuPVc3OiEQvF2= NVmzZoVMW0GQR1XS
SiHa NITRZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELySVFKSzVyPUOyMlQ4OTFizszN NX34VWRiW0GQR1XS
NCI-H1648 NHz3fIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLze4JFUUN3ME2zNk46OzR3IN88US=> M3jJWHNCVkeHUh?=
EFO-21 NIiyXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLoTWM2OD1|Mz6wNFUh|ryP MorYV2FPT0WU
HCC38 NGrDcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHGTWM2OD1|Mz6zPFQyKM7:TR?= MYLTRW5ITVJ?
IA-LM M3r1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLHU4NkUUN3ME2zN{44QDh7IN88US=> NHLFVotUSU6JRWK=
CTV-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXiWGNKSzVyPUOzMlk4QDZizszN Moq3V2FPT0WU
NCI-H446 NWS4RpNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLVc|BKSzVyPUO0MlI3QDlizszN MVjTRW5ITVJ?
IST-SL1 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:4RVVKSzVyPUO0Mlc1ODhizszN MWDTRW5ITVJ?
EW-22 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfkRoNvUUN3ME2zOE44PzV7IN88US=> NUHTToR6W0GQR1XS
JEG-3 NHG4R|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLPdJBKSzVyPUO2MlE4PjZizszN M2[xPHNCVkeHUh?=
LU-65 NFrrOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTYbZBiUUN3ME2zOk4zQTh3IN88US=> MVPTRW5ITVJ?
NCI-H596 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\WdVVKSzVyPUO2Mlk2QTFizszN MWLTRW5ITVJ?
KNS-81-FD MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TNWmlEPTB;M{euNVQ2KM7:TR?= NHfXUlZUSU6JRWK=
NCI-H1793 M1Xuemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4izSmlEPTB;M{euO|A5PiEQvF2= M{LWT3NCVkeHUh?=
NCI-H460 NGPWRWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPYTWM2OD1|OD6wPFc{KM7:TR?= M4PJ[3NCVkeHUh?=
MPP-89 NFjaPGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vLV2lEPTB;M{muOVg5PiEQvF2= NIC3Z|VUSU6JRWK=
D-542MG MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrrTWM2OD1|OT64OFM3KM7:TR?= NGnPc4JUSU6JRWK=
JAR M{LzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHlXIlKSzVyPUSwMlQ4ODVizszN Mn7DV2FPT0WU
NCI-H209 NGjtT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHlUZRKUUN3ME20NE43PzdizszN NGm2e|dUSU6JRWK=
G-402 MlrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjyeGZLUUN3ME20NU4{QTl|IN88US=> Ml7QV2FPT0WU
IST-MES1 M2jEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXobmpKUUN3ME20Nk4yQTN3IN88US=> NW\tOWV2W0GQR1XS
Daoy M3izNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHyyVVhKSzVyPUSyMlU1PzFizszN MmS2V2FPT0WU
EW-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX6S49OUUN3ME20N{4yOjFzIN88US=> NULZWZJTW0GQR1XS
Saos-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LiZWlEPTB;NEOuNVU{PyEQvF2= MUfTRW5ITVJ?
no-10 M{C0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\k[3NKSzVyPUSzMlE4ODJizszN MYnTRW5ITVJ?
HCC1395 M1npfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3robGlEPTB;NEOuOFY1PCEQvF2= NWXRZodTW0GQR1XS
HCE-4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLueYx5UUN3ME20N{44PjZ2IN88US=> M2DLUXNCVkeHUh?=
EW-1 NEL3V4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XBeWlEPTB;NEOuPFA1QSEQvF2= NG[5OJRUSU6JRWK=
OCUB-M NFXqOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XudWlEPTB;NESuN|Y{QCEQvF2= NWLUNocyW0GQR1XS
IGR-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;0TWM2OD12ND60NVE2KM7:TR?= M{HwcnNCVkeHUh?=
NCI-H1838 M1\TSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fLbWlEPTB;NESuOFM1QSEQvF2= MnPXV2FPT0WU
NCI-H2405 M{HEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3jfVJKSzVyPUS0MlU{PCEQvF2= MVPTRW5ITVJ?
GB-1 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M372PGlEPTB;NESuO|Q3OyEQvF2= NWHQXW5WW0GQR1XS
MG-63 NFGyNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz2PIhKSzVyPUS2MlA3QTZizszN NHXx[5JUSU6JRWK=
KP-N-YN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M365[GlEPTB;NE[uOFY4QSEQvF2= NHPGfWZUSU6JRWK=
no-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXaTWM2OD12Nz6wNlQ1KM7:TR?= NX\6N5BVW0GQR1XS
SW948 MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrCZpBzUUN3ME20O{4{Ozd5IN88US=> M3HYeHNCVkeHUh?=
CAMA-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOwSGQ1UUN3ME20O{4{PDN6IN88US=> M{XJeHNCVkeHUh?=
HCC1187 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vq[2lEPTB;NEeuOVEh|ryP MUXTRW5ITVJ?
D-392MG M2LSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLiTWM2OD12Nz62OVE3KM7:TR?= M2rRNHNCVkeHUh?=
647-V MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3wTWM2OD12OT6zOFE1KM7:TR?= NVXmO2hiW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK1/2 / ERK1/2 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK1/2 in sympathetic neurons. Immunoblots were performed with whole cell extracts from sympathetic neurons maintained in the presence of NGF and left untreated or treated with PD184352 at 0.1, 1, 2 or 10 μM for 16 hours. Antibodies to detect total ERK1/2 and phospho-ERK1/2 were used. 

p-ERK5 / ERK5 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK5 in sympathetic neurons.

21762482
Growth inhibition assay
Cell viability; 

PubMed: 29989268     


Relative viability of DU145CR cells treated with PD184352 was significantly less than that of DU145 cells in WST assay. 

29989268
In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

- Collapse

MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

- Collapse
  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

- Collapse
  • Animal Models: PTC cells in athymic mice
  • Formulation: Cremophor EL–95% ethanol (50:50) and dilutes with water
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Related MEK Products

Tags: buy PD184352 (CI-1040) | PD184352 (CI-1040) supplier | purchase PD184352 (CI-1040) | PD184352 (CI-1040) cost | PD184352 (CI-1040) manufacturer | order PD184352 (CI-1040) | PD184352 (CI-1040) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID