PD184352 (CI-1040)

Catalog No.S1020

PD184352 (CI-1040) Chemical Structure

Molecular Weight(MW): 478.67

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

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In DMSO USD 140 In stock
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Cited by 69 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Features First MEK inhibitor to begin clinical development.
Targets
MEK1 [1]
(Cell-free assay)
MEK2 [1]
(Cell-free assay)
17 nM 17 nM
In vitro

CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. [1] The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic protein. [2] CI-1040 inhibits 86% of papillary thyroid carcinoma (PTC) cell growth with the RET/PTC1 rearrangement at 10μM compared with cells treated with DMSO only. CI-1040 shows potent inhibition to PTC cells (BRAF mutation) with GI50 of 52 nM, but low activity to RET/PTC1 rearrangement type with GI50 of 1.1 μM. [3] A recent research indicates CI-1040 increases the apoptotic effect of BMS-214662 in a CML blast crisis cell line, K562, and in primary chronic phase CD34+ CML cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEKyO|Yh|ryP MV\TRW5ITVJ?
CHP-212 NFPLdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PGNmlEPTB;MD6wNlg5PSEQvF2= MYTTRW5ITVJ?
EoL-1-cell MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMESxOVIh|ryP NYDiOWFsW0GQR1XS
DU-4475 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHFTWM2OD1yLkC3OVk6KM7:TR?= MXzTRW5ITVJ?
MMAC-SF MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknDTWM2OD1yLkGwPVc1KM7:TR?= M1fwfXNCVkeHUh?=
AGS MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n6RWlEPTB;MD6xNVcyOyEQvF2= NHzZXXNUSU6JRWK=
M14 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[3U2lEPTB;MD6xOVQ3QCEQvF2= M2H1N3NCVkeHUh?=
CP50-MEL-B M3PGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMUeyOVQh|ryP NV3Nd|BXW0GQR1XS
C32 NXGwOYRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUmwO|Ih|ryP NIq4OIdUSU6JRWK=
KMOE-2 M4XJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i2WGlEPTB;MD6xPVc6PSEQvF2= M1rJeHNCVkeHUh?=
A101D NUfQ[3VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe1TWM2OD1yLkKxOEDPxE1? MYXTRW5ITVJ?
KM12 M3vOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37rfGlEPTB;MD6yOFA2PyEQvF2= MULTRW5ITVJ?
HSC-4 NITp[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfETWM2OD1yLkK0N|k2KM7:TR?= NEP5OFdUSU6JRWK=
NOMO-1 NGDSXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMkW3OFIh|ryP MWnTRW5ITVJ?
MZ7-mel NGrXPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMk[zOEDPxE1? M3[1XHNCVkeHUh?=
ACN NGjMeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvjR2d{UUN3ME2wMlI3PzN5IN88US=> M3HZPHNCVkeHUh?=
MEL-HO NWTNN3ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jzZWlEPTB;MD6yO|Y2OiEQvF2= MULTRW5ITVJ?
BHT-101 M{nWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjveY91UUN3ME2wMlI5PjB4IN88US=> M1uyNXNCVkeHUh?=
SK-MEL-28 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHNR4RKSzVyPUCuN|A1ODlizszN Moi0V2FPT0WU
KG-1 NWDhbFNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{C2Olgh|ryP NF\IVYhUSU6JRWK=
COLO-679 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzwb5FbUUN3ME2wMlMzPzJizszN MXTTRW5ITVJ?
SK-MEL-24 NX32emNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHrTWM2OD1yLkOyPFE{KM7:TR?= NEHEe29USU6JRWK=
G-361 M1jpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rlOWlEPTB;MD6zOlc6PSEQvF2= NXHUclRPW0GQR1XS
KY821 NYjFfIVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe0XolKSzVyPUCuN|c6OSEQvF2= M1TYNXNCVkeHUh?=
KASUMI-1 NIW1RXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfHRW9CUUN3ME2wMlM6QSEQvF2= NInjbWNUSU6JRWK=
HL-60 NW\KSpBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLHTWM2OD1yLkSxNVA4KM7:TR?= NFz2TZRUSU6JRWK=
K5 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnvSoFKSzVyPUCuOFMyOTdizszN MofaV2FPT0WU
KU812 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzpWGR1UUN3ME2wMlQ2Ojl7IN88US=> M1fQSnNCVkeHUh?=
SH-4 NWjtZYo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nYfGlEPTB;MD60OlI2PiEQvF2= M{fGUnNCVkeHUh?=
HTC-C3 M13WU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNE[1N|Eh|ryP M2jV[nNCVkeHUh?=
CP66-MEL M4naZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLZTWM2OD1yLkS4PFA6KM7:TR?= Mn\sV2FPT0WU
WM-115 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwNEmyOVch|ryP MVLTRW5ITVJ?
A2780 NF;EcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\BU2JKSzVyPUCuOFk5OjNizszN NIDmNmVUSU6JRWK=
P12-ICHIKAWA NUH5TIJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPPdlJKSzVyPUCuOlEzOjFizszN MlnyV2FPT0WU
HMV-II M1f1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK5TWM2OD1yLk[0OFY2KM7:TR?= NFHMWZZUSU6JRWK=
HT-144 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTvTWM2OD1yLk[0OlU4KM7:TR?= Mk\CV2FPT0WU
LB2518-MEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LQRmlEPTB;MD63NVY{OiEQvF2= M33JRnNCVkeHUh?=
NCI-SNU-1 NUfyVm9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y1dGlEPTB;MD63OVQ{OyEQvF2= NVfjb4I1W0GQR1XS
C2BBe1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D3VGlEPTB;MD64NVAzOyEQvF2= MmnOV2FPT0WU
PSN1 NX\KOo5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\se5VKSzVyPUCuPVYyQTZizszN Mn7LV2FPT0WU
UACC-257 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwOU[0O|Mh|ryP NXPkO|JCW0GQR1XS
RVH-421 MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwOUexPEDPxE1? MW\TRW5ITVJ?
GP5d NEL0eZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HuN2lEPTB;MD65PFMxQCEQvF2= MY\TRW5ITVJ?
TYK-nu NF;2UHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDtTWM2OD1zLkCzNVczKM7:TR?= M2jDdnNCVkeHUh?=
SK-N-AS M3m3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwMEe5OFch|ryP MYjTRW5ITVJ?
SW620 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHpdXdKSzVyPUGuNVM2OzRizszN NX\VOnNoW0GQR1XS
HuP-T4 NVvZdpFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwMUizOVkh|ryP NV;0XFRFW0GQR1XS
A549 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLXTWM2OD1zLkG5OVc3KM7:TR?= MoXsV2FPT0WU
Mewo NX65ZZB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXQS4dDUUN3ME2xMlIxOjd4IN88US=> M4T2fnNCVkeHUh?=
ONS-76 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEewS2JKSzVyPUGuNlIxPDlizszN M2PWXHNCVkeHUh?=
SK-MEL-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3YTWM2OD1zLkKzOFE6KM7:TR?= NIPHNGhUSU6JRWK=
RCM-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL3VoNKSzVyPUGuNlQxPDdizszN MmPjV2FPT0WU
H-EMC-SS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXJbYlKSzVyPUGuNlk3ODhizszN MYrTRW5ITVJ?
NCI-H2291 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXZTWM2OD1zLkOyOVM3KM7:TR?= NVnoUFQ2W0GQR1XS
SW1463 NXXzbnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHURnVuUUN3ME2xMlM{PzJzIN88US=> M3T1b3NCVkeHUh?=
LS-411N MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrGb2hUUUN3ME2xMlQxPTF5IN88US=> NFnMSIJUSU6JRWK=
BV-173 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LFU2lEPTB;MT60OFAyPSEQvF2= M3e5XnNCVkeHUh?=
LS-513 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDQZpZMUUN3ME2xMlQ2OTl{IN88US=> NEHN[XFUSU6JRWK=
LoVo MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnLZXJVUUN3ME2xMlQ3Ozl7IN88US=> MXfTRW5ITVJ?
HO-1-N-1 NES4PFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn5ZpFKSzVyPUGuOVE3OzRizszN M1G4RnNCVkeHUh?=
ML-2 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPxRpNGUUN3ME2xMlUzQDZ6IN88US=> NXTkXYpPW0GQR1XS
NCI-H1437 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwNUWyO|Uh|ryP M{jsV3NCVkeHUh?=
SW1116 NWrwTHpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPwTWM2OD1zLkW2N|k5KM7:TR?= NH;tRnhUSU6JRWK=
A4-Fuk NX;RSno{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOxOFNKSzVyPUGuOVcxPDVizszN Mn60V2FPT0WU
HD-MY-Z NWX4d5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r0NmlEPTB;MT61O|M4PiEQvF2= Mn\pV2FPT0WU
SK-MEL-2 NV[xTldXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH1W5dDUUN3ME2xMlU4PDV7IN88US=> M1;5bHNCVkeHUh?=
RT-112 NF[0[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELEbXlKSzVyPUGuOVg6PTJizszN NIHlbVVUSU6JRWK=
COLO-829 NGWyNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwNkKyN|Ih|ryP NHjQcGdUSU6JRWK=
OVCAR-5 M2q2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjOTWM2OD1zLke3Olg4KM7:TR?= NFP4WHVUSU6JRWK=
NB69 NEf0ZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\wTWM2OD1zLke4OFY6KM7:TR?= MWjTRW5ITVJ?
NCI-H292 NEnYfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGzTWM2OD1zLki2Olk6KM7:TR?= M2\RfXNCVkeHUh?=
LOXIMVI MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;3UGlEPTB;MT64PVQzPyEQvF2= NUHzdolYW0GQR1XS
BPH-1 M{LuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjsTWM2OD1zLki5OVkyKM7:TR?= NHTOVoxUSU6JRWK=
A375 M3nGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwOEm3NVQh|ryP Mn;LV2FPT0WU
LCLC-97TM1 NF3RR5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1viU2lEPTB;MT65NlI2PiEQvF2= NVe5ZVZlW0GQR1XS
RXF393 MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M133PWlEPTB;MT65O|g5PyEQvF2= MUjTRW5ITVJ?
HCC70 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfabHFVUUN3ME2yMlAzPDJ4IN88US=> NVvLRlNGW0GQR1XS
EM-2 NFjXWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELWepBKSzVyPUKuNFcyQThizszN NIjqRVhUSU6JRWK=
MZ2-MEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwMUGxNlch|ryP MVTTRW5ITVJ?
HN M4fRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrrTWM2OD1{LkG2Nlc5KM7:TR?= MoG3V2FPT0WU
A2058 NHLBUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXVTWM2OD1{LkG5Nlc6KM7:TR?= MWXTRW5ITVJ?
NB7 M1G3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmxTWM2OD1{LkO0NFg3KM7:TR?= M1P1XXNCVkeHUh?=
DOK MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny1TWM2OD1{LkO1O|c{KM7:TR?= NF34blNUSU6JRWK=
CAL-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG2TodKSzVyPUKuN|kzOzZizszN NE\rZWpUSU6JRWK=
BB65-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwNEC2O|Qh|ryP M4\i[XNCVkeHUh?=
RD NXm5PW9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\hbpByUUN3ME2yMlQ1PzJ|IN88US=> M1rpdHNCVkeHUh?=
KNS-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwNUGxOlQh|ryP M{\pdnNCVkeHUh?=
EW-13 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXpNllKSzVyPUKuOVY{OzlizszN M4rJR3NCVkeHUh?=
DB NH7zcJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTNTWM2OD1{LkW4O|g5KM7:TR?= MlzrV2FPT0WU
HCC2218 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfmTWM2OD1{Lk[0O|c5KM7:TR?= M2XWUXNCVkeHUh?=
L-363 NIe4XoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqzPYVpUUN3ME2yMlc1OzdizszN M4fDS3NCVkeHUh?=
CHL-1 NWD1boFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLkfolkUUN3ME2yMlgxPzh3IN88US=> NWXYV3FlW0GQR1XS
BFTC-905 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7hZoVDUUN3ME2yMlgzPTNizszN NXXCO3ZIW0GQR1XS
HCE-T MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHGPGhKSzVyPUKuPFMzPjRizszN M{fB[HNCVkeHUh?=
COLO-792 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJwOESwNlch|ryP MkjPV2FPT0WU
LB2241-RCC NH\Nbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwOEW4PVMh|ryP M3vqN3NCVkeHUh?=
CAL-39 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD0TWM2OD1{Lki5PVk6KM7:TR?= NXPTXZBiW0GQR1XS
T-24 NH;ld5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\lfGVKSzVyPUKuPVEyOTJizszN MY\TRW5ITVJ?
NCI-H727 M3\aNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrNdWlmUUN3ME2yMlkyPzl4IN88US=> MmnsV2FPT0WU
Ca9-22 M{m0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nKSWlEPTB;Mj65O|I2PSEQvF2= NFS3XWZUSU6JRWK=
MIA-PaCa-2 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCwcYRYUUN3ME2zMlAxPzhzIN88US=> NYXIR|BEW0GQR1XS
HT-1080 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMEG5PVch|ryP NFLKTm5USU6JRWK=
D-423MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;DdmlEPTB;Mz6wO|c2OyEQvF2= MX7TRW5ITVJ?
LAMA-84 NIHnZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PFRmlEPTB;Mz6xN|U5KM7:TR?= M3LKbHNCVkeHUh?=
SW780 NWHueHBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3frSWlEPTB;Mz6xOFIzQSEQvF2= MVjTRW5ITVJ?
KU-19-19 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvQTWM2OD1|LkG3NFM1KM7:TR?= M1O5fnNCVkeHUh?=
COLO-741 NYS5UGQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPCdYZKSzVyPUOuNVg3PzNizszN MXXTRW5ITVJ?
HSC-3 NH7I[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP1bpYzUUN3ME2zMlI{OTVzIN88US=> M1TLVnNCVkeHUh?=
SN12C MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3NTWM2OD1|LkK0O|AyKM7:TR?= NYXJVVV1W0GQR1XS
786-0 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon1TWM2OD1|LkK3NlQ{KM7:TR?= MkHkV2FPT0WU
GAK NY\1TnRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwM{K1OlEh|ryP M37p[XNCVkeHUh?=
PANC-03-27 M{fDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu1TWM2OD1|LkO1NFQ2KM7:TR?= Mo[zV2FPT0WU
CTB-1 M336e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnDVodvUUN3ME2zMlQ4ODR5IN88US=> MmDKV2FPT0WU
A427 NWrrRmVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfUclNbUUN3ME2zMlU6PTV4IN88US=> NHXLXW1USU6JRWK=
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Calu-3 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF7LkSyN|ch|ryP MUHTRW5ITVJ?
NCI-H1048 NHjacZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJyLkOyOlYh|ryP MlPmV2FPT0WU
NCI-H226 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K1bWlEPTB;MkCuOFM6QSEQvF2= M4XaW3NCVkeHUh?=
FTC-133 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rYPGlEPTB;MkCuOFcxOyEQvF2= M{P0dnNCVkeHUh?=
SF539 NXW5VmQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjTc2E4UUN3ME2yNE42OTd{IN88US=> NVLQW49rW0GQR1XS
TE-6 NHLnNVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\u[|FDUUN3ME2yNE45ODZ5IN88US=> M1SyfnNCVkeHUh?=
UMC-11 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLJTWM2OD1{MD65NVY1KM7:TR?= MnvLV2FPT0WU
Becker NHToOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITTbFBKSzVyPUKxMlEyOThizszN NVzaVZRzW0GQR1XS
KP-4 M33OZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjKPWhOUUN3ME2yNU4yOTl4IN88US=> MWXTRW5ITVJ?
ChaGo-K-1 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJzLkO2Nlch|ryP MV7TRW5ITVJ?
CFPAC-1 M3jQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XEOmlEPTB;MkGuN|g2QCEQvF2= Mo[yV2FPT0WU
A498 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJzLkWzNVIh|ryP NH72VlJUSU6JRWK=
NCI-H1755 NUnHb5ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJzLk[3OFEh|ryP M2DETXNCVkeHUh?=
TI-73 M1LFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PpXGlEPTB;MkKuN|I5KM7:TR?= MX\TRW5ITVJ?
NCI-H441 M4rsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJ{LkW2PFkh|ryP NEDlUWdUSU6JRWK=
CaR-1 NFXHPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXwVVJKSzVyPUKzMlAzOTNizszN MkDOV2FPT0WU
HCC1806 M{jDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjRcIlEUUN3ME2yN{4xPTh|IN88US=> NXnldow4W0GQR1XS
SNU-449 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzURoVvUUN3ME2yN{4{OjlizszN MVvTRW5ITVJ?
EKVX M4XOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3IcXFtUUN3ME2yN{4{QTB7IN88US=> MmD4V2FPT0WU
DMS-114 M3LvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17rSmlEPTB;MkOuOVc3PSEQvF2= NULDe4t5W0GQR1XS
A704 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ|Lk[xNFMh|ryP NFHwPItUSU6JRWK=
LC-2-ad M1rqNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ|Lk[xOFch|ryP NXSxPWx7W0GQR1XS
VM-CUB-1 NFO1PJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\PW2RGUUN3ME2yN{44OzRzIN88US=> MYDTRW5ITVJ?
PC-3 NIXT[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XjTWlEPTB;MkSuNFUzPiEQvF2= M4PJenNCVkeHUh?=
HEL M3;3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv4TWM2OD1{ND6wPFY2KM7:TR?= NWfrRVJXW0GQR1XS
ABC-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV36OnNuUUN3ME2yOE4zPzJ7IN88US=> MkizV2FPT0WU
COLO-680N Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PMPGlEPTB;MkSuOFc3PCEQvF2= NXjLUXVlW0GQR1XS
MZ1-PC M3vic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ2Lk[4O{DPxE1? MkDTV2FPT0WU
NCI-H69 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ2LkezOVQh|ryP NGTOXo5USU6JRWK=
TE-1 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDuOolKSzVyPUK1MlA1QTlizszN M2HoV3NCVkeHUh?=
EW-3 MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrSPXVGUUN3ME2yOU4yOTNizszN MUPTRW5ITVJ?
PANC-08-13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7mbZpKSzVyPUK1MlgyODNizszN NIfjTpBUSU6JRWK=
NMC-G1 NE\zVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnBUnlWUUN3ME2yOk4xODh6IN88US=> M1uyT3NCVkeHUh?=
BT-20 NUnYXZh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJ4LkS1OFMh|ryP M1;lSHNCVkeHUh?=
TGBC24TKB NEPWfHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHnO|NOUUN3ME2yOk44OzNzIN88US=> MVjTRW5ITVJ?
TE-11 M3\xPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\WOoNKSzVyPUK2Mlk5QTVizszN NHfHUVdUSU6JRWK=
ESS-1 M{fhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLFZW1zUUN3ME2yO{4{OjF4IN88US=> MlT6V2FPT0WU
JVM-3 M2jXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJ5Lk[0O|Uh|ryP M4XuOnNCVkeHUh?=
C3A NWLT[lZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M371bWlEPTB;MkeuPFQ6PiEQvF2= M4Oze3NCVkeHUh?=
MDA-MB-157 NGDZPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXGTWM2OD1{Nz64O|U{KM7:TR?= MVjTRW5ITVJ?
KLE NV64RnNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfUSZNKSzVyPUK4MlExPThizszN NXTzS2NxW0GQR1XS
ES1 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmxTWM2OD1{OD6xPFM5KM7:TR?= NWn4dnl3W0GQR1XS
CAL-120 M1;rZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[2N29KSzVyPUK4MlM6QTlizszN NV7mNXhLW0GQR1XS
NCI-N87 NIHsPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvRTWM2OD1{OD61NVA2KM7:TR?= M{WwN3NCVkeHUh?=
RPMI-8226 NHLITnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJ7LkG4OFMh|ryP NY\DVlYyW0GQR1XS
COR-L88 M1WzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ7LkK0NVkh|ryP NIm5c2ZUSU6JRWK=
UACC-893 NEHJOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ7LkOxN|ch|ryP M2K2cnNCVkeHUh?=
C8166 NF;ybW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS5SmhKSzVyPUK5Mlk6QTZizszN MV3TRW5ITVJ?
J82 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS1TWM2OD1|MD64NVQ4KM7:TR?= M2fheHNCVkeHUh?=
PFSK-1 MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNzLkC2OVkh|ryP NIHuV2VUSU6JRWK=
COLO-684 NGnKc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;oTWM2OD1|MT60N|c1KM7:TR?= NGTCXYxUSU6JRWK=
CAL-72 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:zTo9KSzVyPUOxMlU4OjlizszN NEO1PVZUSU6JRWK=
SNB75 M3q1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNzLki5O{DPxE1? MkjtV2FPT0WU
MDA-MB-415 M3jB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fwR2lEPTB;M{GuPVc3OiEQvF2= NEnJeFNUSU6JRWK=
SiHa NXjseZc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr0NHFwUUN3ME2zNk41PzFzIN88US=> MnnKV2FPT0WU
NCI-H1648 NWXLOFNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj4bY5KSzVyPUOyMlk{PDVizszN M3jqcnNCVkeHUh?=
EFO-21 NEnLTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq3VIFlUUN3ME2zN{4xODVizszN MkHVV2FPT0WU
HCC38 NHT4SYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrTXmpKSzVyPUOzMlM5PDFizszN MmDkV2FPT0WU
IA-LM NFL5em9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqyUHY4UUN3ME2zN{44QDh7IN88US=> NHPtZYVUSU6JRWK=
CTV-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWySWZKSzVyPUOzMlk4QDZizszN M3fu[3NCVkeHUh?=
NCI-H446 M3rKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrNR|JKSzVyPUO0MlI3QDlizszN Mm\0V2FPT0WU
IST-SL1 NHzPfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN2Lke0NFgh|ryP MkX1V2FPT0WU
EW-22 NXzP[2NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrRcpBXUUN3ME2zOE44PzV7IN88US=> NWX1WVB1W0GQR1XS
JEG-3 Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf1dXdsUUN3ME2zOk4yPzZ4IN88US=> NYm4bY5iW0GQR1XS
LU-65 NF;KdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHRTWM2OD1|Nj6yPVg2KM7:TR?= MV\TRW5ITVJ?
NCI-H596 NV;SSGtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TDc2lEPTB;M{[uPVU6OSEQvF2= NITWPVNUSU6JRWK=
KNS-81-FD NWnqb2RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXPTWM2OD1|Nz6xOFUh|ryP MWfTRW5ITVJ?
NCI-H1793 M1npfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO1Xm1UUUN3ME2zO{44ODh4IN88US=> NIflcZNUSU6JRWK=
NCI-H460 NXHs[XRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwWGlEPTB;M{iuNFg4OyEQvF2= NHXHTXBUSU6JRWK=
MPP-89 NX3p[4Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTN7LkW4PFYh|ryP MWPTRW5ITVJ?
D-542MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nvVmlEPTB;M{muPFQ{PiEQvF2= M125UnNCVkeHUh?=
JAR M3y3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjITWM2OD12MD60O|A2KM7:TR?= NWL5NWd2W0GQR1XS
NCI-H209 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWwR4ZKSzVyPUSwMlY4PyEQvF2= M2TlTXNCVkeHUh?=
G-402 NFHYV3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7LVXZFUUN3ME20NU4{QTl|IN88US=> M2W1dnNCVkeHUh?=
IST-MES1 NVjMTppJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqzV2VKSzVyPUSyMlE6OzVizszN NInY[25USU6JRWK=
Daoy NHLOS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjRe4V[UUN3ME20Nk42PDdzIN88US=> M4TR[3NCVkeHUh?=
EW-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR|LkGyNVEh|ryP M{frbXNCVkeHUh?=
Saos-2 NFXpZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvpTWM2OD12Mz6xOVM4KM7:TR?= M1z1OHNCVkeHUh?=
no-10 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jpXmlEPTB;NEOuNVcxOiEQvF2= Ml\SV2FPT0WU
HCC1395 NGO5fWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnMTWM2OD12Mz60OlQ1KM7:TR?= M{TJXHNCVkeHUh?=
HCE-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR|Lke2OlQh|ryP M1jxVHNCVkeHUh?=
EW-1 NVm3S45tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR|LkiwOFkh|ryP NFHZXVVUSU6JRWK=
OCUB-M M{H0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jaSmlEPTB;NESuN|Y{QCEQvF2= NYDwWIlIW0GQR1XS
IGR-1 NWHNOVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTR2LkSxNVUh|ryP M3PyXXNCVkeHUh?=
NCI-H1838 M{jzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTR2LkSzOFkh|ryP MXjTRW5ITVJ?
NCI-H2405 M4LVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTR2LkWzOEDPxE1? M1PoSXNCVkeHUh?=
GB-1 NIjrTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTR2Lke0OlMh|ryP MVPTRW5ITVJ?
MG-63 M3H2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnyTWM2OD12Nj6wOlk3KM7:TR?= MoTZV2FPT0WU
KP-N-YN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjETWM2OD12Nj60Olc6KM7:TR?= MXXTRW5ITVJ?
no-11 M3rp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fjPGlEPTB;NEeuNFI1PCEQvF2= M3nqNXNCVkeHUh?=
SW948 NUCwbWkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLaWoNKSzVyPUS3MlM{PzdizszN MX3TRW5ITVJ?
CAMA-1 M4rOT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm1OItUUUN3ME20O{4{PDN6IN88US=> M37Jb3NCVkeHUh?=
HCC1187 NFSzSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXMTWM2OD12Nz61NUDPxE1? NG\qS4pUSU6JRWK=
D-392MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLJO|NZUUN3ME20O{43PTF4IN88US=> NX:0SpIxW0GQR1XS
647-V MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTR7LkO0NVQh|ryP NF;Od|JUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK1/2 / ERK1/2 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK1/2 in sympathetic neurons. Immunoblots were performed with whole cell extracts from sympathetic neurons maintained in the presence of NGF and left untreated or treated with PD184352 at 0.1, 1, 2 or 10 μM for 16 hours. Antibodies to detect total ERK1/2 and phospho-ERK1/2 were used. 

p-ERK5 / ERK5 ; 

PubMed: 21762482     


Effect of PD184352 on phosphorylation of ERK5 in sympathetic neurons.

21762482
Growth inhibition assay
Cell viability; 

PubMed: 29989268     


Relative viability of DU145CR cells treated with PD184352 was significantly less than that of DU145 cells in WST assay. 

29989268
In vivo Oral dosing of CI-1040 impairs the growth of colon tumor xenografts of mouse and human with a wide dose range of 48-200 mg/kg per dose, but not of P388 leukemia. [1] CI-1040 inhibits the tumor xenografts from PTC cells carrying a BRAF mutation with 31.3% reduction, carrying the RET/PTC1 rearrangement with 47.5% reduction than in untreated (vehicle) mice after 3 weeks of oral administration (300 mg/kg/d). No toxic effects are observed in any mice when they are treated with CI-1040. [2] Transient exposure of mammary tumors to CI-1040 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Combined treatment with CI-1040 (25 mg/kg) and UCN-01 (0.1-0.2 mg/kg) significantly reduces MDA-MB-231, and largely abolishs MCF7 tumor growth in implanted athymic mice, while either single treatment has no significant activity. The drug combination leads to profound tumor cell death which correlates with a reduction in the phosphorylation of ERK1/2 and the immuno-reactivity of Ki67 and of CD31. [5]

Protocol

Kinase Assay:

[2]

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MEK1 Assay:

MAP kinase is activated after phosphorylation by MEK; the activated MAP kinase subsequently phosphorylates myelin basic protein (MBP).Incorporation of 32P into myelin basic protein (MBP) is assayed in the presence of glutathione S-transferase (GST) fusion proteins containing the 44-kDa MAPK (GST-MAPK) or the 45-kDa MEK (GST-MEK1). Assays are conducted in 50μL of 50 mM Tris, pH 7.4/10 mM MgCl2 /2 mM EGTA/10 μM [γ-32P]ATP containing 10 μg of GST-MEK1, 0.5 μg of GST-MAPK, and 40 μg of MBP. After incubation at 30°C for 15 minutes, reactions are stopped by addition of Laemmli SDS sample buffer. Phosphorylated MBP is resolved by SDS/10% PAGE. This screening effort leads to the discovery of several small-molecule inhibitors of MEK, i.e. CI-1040. Experiments assessing the order of addition shows that CI-1040 directly inhibits MEK1 with a 50% inhibitory concentration (IC50) of 17 nM, without affecting the activity of MAPK.
Cell Research:

[1]

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  • Cell lines: Colon 26 carcinoma cells
  • Concentrations: 0.1-10 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are planted seeded in T-75 cm 2 flasks and treated the next day for 24 hous with either DMSO or CI-1040. Single-cell suspensions are collected, and pellets are fixed in ice-cold ethanol (70%) for 30 minutes. After centrifugation of the samples, propidium iodide (50 μg/mL) and RNase (30 units/mL) are added to the pellets for 20 minutes at 37 °C. After filtration, samples are analyzed by flow cytometry.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: PTC cells in athymic mice
  • Formulation: Cremophor EL–95% ethanol (50:50) and dilutes with water
  • Dosages: 150 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.55 mM)
Ethanol 14 mg/mL (29.24 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol, pH 9
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 478.67
Formula

C17H14ClF2IN2O2

CAS No. 212631-79-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID