Tamoxifen

For research use only.

Catalog No.S1238 Synonyms: ICI 46474

25 publications

Tamoxifen Chemical Structure

CAS No. 10540-29-1

Tamoxifen (ICI 46474) is an antagonist of the estrogen receptor in breast tissue. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.

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Selleck's Tamoxifen has been cited by 25 publications

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Biological Activity

Description Tamoxifen (ICI 46474) is an antagonist of the estrogen receptor in breast tissue. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MYPGeY5kfGmxbjDhd5NigQ>? NGrDWHhG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> MkHJNVI5OjV7M{W=
MCF7 cells NYDQV5FnS3m2b4TvfIlkcXS7IHHzd4F6 MnTvOFghcA>? NXv2S|lGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ5IN88US=> MlPXNlI1PzJyNEW=
Ishikawa cells NUHhPHhpTnWwY4Tpc44h[XO|YYm= NHS2UVZEd26lZX70doF1cW:wIH;mJINwdXCxdX7kJJJmeXWrcnXkJJRwKGmwZIXj[UA2OCBnIH;mJJRp\SCvYYjpcZVuKHO2aX31cIF1cW:wIH;mJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGmwIFnzbIls[XejIHPlcIx{NCCHQ{WwQVAvODN|IN88US=> M4K4VlgzODF3OEe=
HEK293T cells NWT5T4llTnWwY4Tpc44h[XO|YYm= M3;Rd2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> MVyyN|c5PjR3Mh?=
MDA-MB-435 cells MoXySpVv[3Srb36gZZN{[Xl? M4Xp[WlvcGmkaYTpc44hd2ZiTVTBMW1DNTR|NTDidoVie3RiY3HuZ4VzKGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjB3IN88US=> MVmxOFk4OTh7OR?=
MDA-MB-231 cells NFjZe5VHfW6ldHnvckBie3OjeR?= NXfVRoRuUW6qaXLpeIlwdiCxZjDld5Rzd2enbjDy[YNmeHSxcjDu[YdifGm4ZTDNSGEuVUJvMkOxJIJz\WG|dDDjZY5k\XJiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEig{txO M2D1dVE1QTdzOEm5
T47D cells Mn3TSpVv[3Srb36gZZN{[Xl? NHzJRlVCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDUOFdFKGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5Ih[XO|ZYPz[YQh[XNiZYP0do9o\W5vZHXw[Y5l\W62IITyZY5{[3KrcITpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNUDPxE1? NWPDVZNyOTlzM{GyOFg>
Ishikawa cells NYWybnJjTnWwY4Tpc44h[XO|YYm= MYC3NkBp MkXzRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{b3flck1qdmS3Y3XkJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGGodHXyJFczKGi{czygTWM2OD1yLkG3JO69VQ>? Mlz6NVg5OzVzN{[=
MCF-7-2a cells MlGwSpVv[3Srb36gZZN{[Xl? MV\BcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDNR2YuPy1{YTDj[YxteyCjczDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SCnc4TyZYRqd2xiZX\m[YN1KGK7IEWwKUwhUUN3ME2wMlUh|ryP Mn35NVI1OzFyNkO=
EL4 cell NX2xNoxSWHKxbHnm[ZJifGmxbjDhd5NigQ>? NXWxOJVIUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= Mle1NVU4OzZ|MB?=
HeLa cells MmrKSpVv[3Srb36gZZN{[Xl? M1PnXGlvcGmkaYTpc44hd2ZiMUetZoV1[S2nc4TyZYRqd2xibXXkbYF1\WRibIXjbYZmemG|ZTD0doFve2O{aYD0bY9vKGmwIFjlUIEh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDhcJBp[TtiRWLFJIF{e2G7LDDJR|UxRTBwNkKyJO69VQ>? NUT6To02OTV4NUi4OVE>
MDA-MB-231 cells MUnQdo9tcW[ncnH0bY9vKGG|c3H5 M2HwU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD62OkDPxE1? MnnqNlA1PTF|OEC=
T47D cells MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnkWmRjPzJiaB?= NIP1RndIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBme3S{b3flck1l\XCnbnTlcpQhXDR5RDDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MTFOwG0> M2K3XlE6OTNzMkS4
yeast AH109 cells MWDGeY5kfGmxbjDhd5NigQ>? NHn6R4czPCCq MnHpRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnLleIEhemWlZYD0c5IhVEKGIHX4dJJme3OnZDDpckB6\WG|dDDBTFExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIlvfGW{YXP0bY9vKHerdHigV3JEOSCjZoTldkAzPCCqcoOgZpkh[WyyaHGt[4Ft[WO2b4Pp[IF{\SCjc4PhfUwhUUN3ME2xMlY3KM7:TR?= M2XvZVIzPjR5MkG3
GBM2 cells MVjQdo9tcW[ncnH0bY9vKGG|c3H5 MWG3NkBp M4HVXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVMvPSEQvF2= M1nTZlI3OzV3NUOy
NCI-H460 cells MljlSpVv[3Srb36gZZN{[Xl? NXy3S2c1OjRiaB?= Mle3RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyIHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE41QCEQvF2= NFHC[5YyQTd|M{C4OS=>
GBM3 cells MlK0VJJwdGmoZYLheIlwdiCjc4PhfS=> M2SzN|czKGh? NGLrW4tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVMh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF01NjdizszN M2TpZ|I3OzV3NUOy
DLD1 cells NX;UUZBGS3m2b4TvfIlkcXS7IHHzd4F6 MXu5OkBp NW[1Om5zS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEyGMTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPzhizszN MkDuNlI4PDl|OUK=
ScN2a-cl3 cells M2PNPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2C3clUh\GG7cx?= NEH3bIpEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBlcX[rZHnu[{BU[05{YT3jcFMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNTDkZZl{KGK7IHPhcINmcW5vQV2gd5RicW6rbnetZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTRwOEmg{txO MmW3NlQyQDN3OEm=
K562 cells NFHReGZRem:uaX\ldoF1cW:wIHHzd4F6 M4D2ZVczKGh? Ml[0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME21MlIh|ryP MXWyOVQzODF5NR?=
MDA-MB-435S cells NH:1ZoFEgXSxdH;4bYNqfHliYYPzZZk> MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDifUBOXFRiYYPzZZktKEmFNUC9OU42KM7:TR?= NHzBO3AzPjB5OUC5NC=>
DU145 cells NVfOfGU2WHKxbHnm[ZJifGmxbjDhd5NigQ>? MmjtOFghcA>? MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS53IN88US=> NW\2VYhnOjN{OEewOVc>
HepG2 cells NV;zNmdEWHKxbHnm[ZJifGmxbjDhd5NigQ>? M3LJV|Q5KGh? M3LORWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14LkOg{txO NYSwTpdKOjN{OEewOVc>
SKOV3 cells M4PxVGZ2dmO2aX;uJIF{e2G7 MYSyOEBp NISzV4xCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME22MlQh|ryP NIm5TIgyQTd|M{C4OS=>
PC3 cells Ml;BVJJwdGmoZYLheIlwdiCjc4PhfS=> NXTvSGQ3OjRiaB?= MkfiRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF04KM7:TR?= M{Kw[lI1QDhyMkOw
NIH/3T3 cells NVzqU2ZCS3m2b4TvfIlkcXS7IHHzd4F6 NHG5N5o6PiCq NX3aZYV2S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTdwMk[g{txO MlTYNlI4PDl|OUK=
GBM1 cells M4PpRnBzd2yrZnXyZZRqd25iYYPzZZk> M3TuNVczKGh? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME23MlUh|ryP NFnEepkzPjN3NUWzNi=>
518A2 cells NFHPWnNEgXSxdH;4bYNqfHliYYPzZZk> MnzHPVYhcA>? Ml;UR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gOVE5STJiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23MlYzKM7:TR?= NU\qfFFUOjJ5NEmzPVI>
A2780 cells MUDDfZRwfG:6aXPpeJkh[XO|YYm= M37yd|k3KGh? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuO|ch|ryP NVrBOpNFOjJ5NEmzPVI>
A549 cells M4r0SGN6fG:2b4jpZ4l1gSCjc4PhfS=> NILpN3VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OD16LkSg{txO Ml;MNlYxPzlyOUC=
Lipo cells NYDTdYxHS3m2b4TvfIlkcXS7IHHzd4F6 NGPoW5o6PiCq NG\Jc2VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNcXCxIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE43PCEQvF2= NUDVfY52OjJ5NEmzPVI>
A253 cells M4HqTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGTwW486PiCq M3;yeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= NUfpW3l1OjJ5NEmzPVI>
HT-29 cells MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mkn5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTHQuOjliY3XscJMtKEmFNUC9PU42KM7:TR?= M3;0bFI{PDB|MEi0
LNCAP cells NInKeYJRem:uaX\ldoF1cW:wIHHzd4F6 MUS0PEBp MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHX4dJJme3OrbnegZY5lem:pZX6gdoVk\XC2b4KgbY5kfWKjdHXkJJdqfGhiMD62JI5OKG:oIHXzeJJi\GmxbDDhcoQhOC55IH7NJI9nKHSnc4Tvd5Rmem:wZTDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2xNEDPxE1? M2X4NFIyPTF|Mke1
M21 cells NH;qUpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEmyW|ZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOOjFiY3XscJMtKEmFNUC9NVEh|ryP NH72W24zOzRyM{C4OC=>
850C cells NGrYZXJEgXSxdH;4bYNqfHliYYPzZZk> M1PscVk3KGh? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC4OVBEKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MUGuNFkh|ryP NEDGOnIzOjd2OUO5Ni=>
HL60 cells NYf5OVhGS3m2b4TvfIlkcXS7IHHzd4F6 MY[3NkBp MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3QyKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIEKwKUBHSlNuIFnDOVA:OTRwMzFOwG0> M3y2SVIzQTBzOEm1
MSTO-211H cells NVLzfYJbWHKxbHnm[ZJifGmxbjDhd5NigQ>? NF;JNXI4OiCq MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2VVF:tNlEyUCClZXzsd{Bi\nSncjC3NkBpenNiYomgeJJ6eGGwIHLseYUh[XO|YYmsJGlEPTB;MkOuN{DPxE1? M2\GR|I{PzN3OEK5
HepG2 cells NIrWNVJEgXSxdH;4bYNqfHliYYPzZZk> M2XKXlI1KGh? MmLNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNmdGyWaYTldk1DdHWnQ3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOO69VQ>? NFHWU2QzODV2NUOzOC=>
KIF5 cells MV\DfZRwfG:6aXPpeJkh[XO|YYm= NFTLeXkzPCCq MXnUc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN MUWyNlc4PTR5NB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Pdx1PB-CreERTm mice
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Water Insoluble
Ethanol '''74 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474
Smiles CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04433494 Not yet recruiting Drug: TY-302: capsule 25mg/50mg ; Tamoxifen: tablet10mg Breast Cancer|Solid Tumor TYK Medicines Inc September 2020 Phase 1
NCT04174352 Recruiting Drug: Tamoxifen|Diagnostic Test: FES PET/CT ERα+ Breast Cancer|ESR1 Gene Mutation University of Wisconsin Madison September 2020 Early Phase 1
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester February 1 2020 Phase 1
NCT04312347 Recruiting Drug: Tamoxifen dose adjustment ER+ Breast Cancer Nalagenetics Pte Ltd September 6 2019 Not Applicable
NCT03582865 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer Assiut University September 1 2019 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID