Tamoxifen

For research use only.

Catalog No.S1238 Synonyms: ICI 46474

25 publications

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.

Size Price Stock Quantity  
USD 147 In stock
USD 297 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Tamoxifen has been cited by 25 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MWfGeY5kfGmxbjDhd5NigQ>? NEHDZmpG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> Ml35NVI5OjV7M{W=
MCF7 cells MlzkR5l1d3SxeHnjbZR6KGG|c3H5 MXy0PEBp M1TnUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlAzPyEQvF2= MonnNlI1PzJyNEW=
Ishikawa cells MnrUSpVv[3Srb36gZZN{[Xl? MnvBR49v[2WwdILheIlwdiCxZjDjc41xd3WwZDDy[ZF2cXKnZDD0c{BqdmS3Y3WgOVAhLSCxZjD0bIUhdWG6aX31cUB{fGmvdXzheIlwdiCxZjDhcItidGmwZTDwbI9{eGijdHHz[UBi[3Srdnn0fUBqdiCLc3jpb4F4[SClZXzsd{whTUN3ME2wMlA{OyEQvF2= M3\5d|gzODF3OEe=
HEK293T cells NV\s[VlFTnWwY4Tpc44h[XO|YYm= NI\FeI5CdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFfhcFQhTEKGLX\1d4VlKGi3bXHuJGVT[WyyaHGgUGJFKGW6cILld5Nm\CCrbjDISWszQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\XO2cnHkbY9tNWmwZIXj[YQhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgNlAhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF0xNjB|OTFOwG0> NIPRbGYzOzd6NkS1Ni=>
MDA-MB-435 cells M{HlWWZ2dmO2aX;uJIF{e2G7 M3rkSWlvcGmkaYTpc44hd2ZiTVTBMW1DNTR|NTDidoVie3RiY3HuZ4VzKGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjB3IN88US=> NEnjToEyPDl5MUi5PS=>
MDA-MB-231 cells M1PwdGZ2dmO2aX;uJIF{e2G7 MnTHTY5pcWKrdHnvckBw\iCnc4Tyc4dmdiC{ZXPldJRweiCwZXfheIl3\SCPRFGtUWIuOjNzIHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODhizszN MVWxOFk4OTh7OR?=
T47D cells MYXGeY5kfGmxbjDhd5NigQ>? NH7YW3VCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDUOFdFKGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5Ih[XO|ZYPz[YQh[XNiZYP0do9o\W5vZHXw[Y5l\W62IITyZY5{[3KrcITpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNUDPxE1? NUnu[ZpJOTlzM{GyOFg>
Ishikawa cells NGLk[ppHfW6ldHnvckBie3OjeR?= MY[3NkBp MXXBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCLc3jpb4F4[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKxZ3XuMYlv\HWlZXSgZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwMUeg{txO MnO0NVg5OzVzN{[=
MCF-7-2a cells NWLKdYxITnWwY4Tpc44h[XO|YYm= MVrBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDNR2YuPy1{YTDj[YxteyCjczDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SCnc4TyZYRqd2xiZX\m[YN1KGK7IEWwKUwhUUN3ME2wMlUh|ryP NIL2TIUyOjR|MUC2Ny=>
EL4 cell M1H4RnBzd2yrZnXyZZRqd25iYYPzZZk> NXnPW5UxUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= NV\sUHdUOTV5M{[zNC=>
HeLa cells MlPwSpVv[3Srb36gZZN{[Xl? NULncnB5UW6qaXLpeIlwdiCxZjCxO{1j\XSjLXXzeJJi\GmxbDDt[YRq[XSnZDDseYNq\mW{YYPlJJRz[W6|Y4LpdJRqd25iaX6gTIVN[SClZXzsd{BmgHC{ZYPzbY5oKGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijOzDFVmUh[XO|YYmsJGlEPTB;MD62NlIh|ryP MV[xOVY2QDh3MR?=
MDA-MB-231 cells Mn70VJJwdGmoZYLheIlwdiCjc4PhfS=> M3ezRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD62OkDPxE1? MXqyNFQ2OTN6MB?=
T47D cells NUK5bZhXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TO[FczKGh? NWjVXndTT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h\XO2cn;n[Y4u\GWyZX7k[Y51KFR2N1SgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGg{txO MYexPVE{OTJ2OB?=
yeast AH109 cells NWrUPVE2TnWwY4Tpc44h[XO|YYm= MWGyOEBp NV\PVIw{SW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoJmfGFicnXj[ZB1d3JiTFLEJIV5eHKnc4Pl[EBqdiC7ZXHzeEBCUDFyOTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGmwdHXyZYN1cW:wIIfpeIghW1KFMTDh[pRmeiB{NDDodpMh[nliYXzwbIEu\2GuYXP0c5Nq\GG|ZTDhd5NigSxiSVO1NF0yNjZ4IN88US=> Mn7LNlI3PDd{MUe=
GBM2 cells NH2yNmFRem:uaX\ldoF1cW:wIHHzd4F6 NUjFSpNFPzJiaB?= NIHHc4ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF0{NjVizszN MlK2NlY{PTV3M{K=
NCI-H460 cells NYnaVnBSTnWwY4Tpc44h[XO|YYm= M3n5b|I1KGh? NIP6fGRCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF01NjR6IN88US=> Mk\MNVk4OzNyOEW=
GBM3 cells MonnVJJwdGmoZYLheIlwdiCjc4PhfS=> NVvWfXBjPzJiaB?= MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME20Mlch|ryP NGDoNmczPjN3NUWzNi=>
DLD1 cells NFfPZ5BEgXSxdH;4bYNqfHliYYPzZZk> NWXJZmVXQTZiaB?= NIe2XFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFVERzIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE44QCEQvF2= MlLpNlI4PDl|OUK=
ScN2a-cl3 cells M2\nVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUK3V2VFPSCmYYnz NVLpRZVwS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4Uh\Gm4aXTpcochW2OQMnGtZ4w{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEWg[IF6eyCkeTDjZYxk\WmwLVHNJJN1[WmwaX7nMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD12Lki5JO69VQ>? MXKyOFE5OzV6OR?=
K562 cells NYTxW2F4WHKxbHnm[ZJifGmxbjDhd5NigQ>? MXS3NkBp MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NULFSlBNOjV2MkCxO|U>
MDA-MB-435S cells M3;Q[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2[0XmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|VUKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDhd5NigSxiSVO1NF02NjVizszN MUWyOlA4QTB7MB?=
DU145 cells NH\HTmpRem:uaX\ldoF1cW:wIHHzd4F6 NVO4T41mPDhiaB?= M3PqV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13LkWg{txO NYTFWXdSOjN{OEewOVc>
HepG2 cells NXnYOWF2WHKxbHnm[ZJifGmxbjDhd5NigQ>? M2WxXlQ5KGh? MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi5|IN88US=> NV\OPGJoOjN{OEewOVc>
SKOV3 cells MXvGeY5kfGmxbjDhd5NigQ>? MoD4NlQhcA>? NGDm[XNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME22MlQh|ryP M3fQfFE6PzN|MEi1
PC3 cells NXvGdoZGWHKxbHnm[ZJifGmxbjDhd5NigQ>? NGO3WmczPCCq MoLhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF04KM7:TR?= M4jMSFI1QDhyMkOw
NIH/3T3 cells NIjSeWJEgXSxdH;4bYNqfHliYYPzZZk> NIjZT286PiCq MkjyR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUmlJNzOWMzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvOjZizszN NYezeYxmOjJ5NEmzPVI>
GBM1 cells NHy4XYhRem:uaX\ldoF1cW:wIHHzd4F6 NYHDR5cyPzJiaB?= MkfGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJQl2xJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDXV3QuOSCvZYToc4QtKEmFNUC9O{42KM7:TR?= MmewNlY{PTV3M{K=
518A2 cells NGj5SWZEgXSxdH;4bYNqfHliYYPzZZk> NF[zOm86PiCq MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuOlIh|ryP NVGzZWh7OjJ5NEmzPVI>
A2780 cells NVniUVVLS3m2b4TvfIlkcXS7IHHzd4F6 NXjKPYtwQTZiaB?= NVP6WVhNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTJ5OECgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04Njd5IN88US=> MW[yNlc1QTN7Mh?=
A549 cells M2izTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFvneGlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OD16LkSg{txO MnnRNlYxPzlyOUC=
Lipo cells NGKyRVFEgXSxdH;4bYNqfHliYYPzZZk> Ml3pPVYhcA>? NXTUT|JuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN MXGyNlc1QTN7Mh?=
A253 cells MVrDfZRwfG:6aXPpeJkh[XO|YYm= NVXPUXF5QTZiaB?= M1\iW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= M2\ySFIzPzR7M{my
HT-29 cells MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY\heJVVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMkmgZ4VtdHNuIFnDOVA:QS53IN88US=> M4fv[FI{PDB|MEi0
LNCAP cells M1L6OXBzd2yrZnXyZZRqd25iYYPzZZk> M{PFTVQ5KGh? NGP5ZXBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIV5eHKnc4Ppcoch[W6mcn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE43KG6PIH;mJIV{fHKjZHnvcEBidmRiMD63JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0yOCEQvF2= MUGyNVUyOzJ5NR?=
M21 cells MlOyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3zKSWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG0zOSClZXzsd{whUUN3ME2xNUDPxE1? NFHaVIIzOzRyM{C4OC=>
850C cells NHPSOYJEgXSxdH;4bYNqfHliYYPzZZk> MWS5OkBp MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC4OVBEKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MUGuNFkh|ryP NFq0TXczOjd2OUO5Ni=>
HL60 cells NH3Wdo1EgXSxdH;4bYNqfHliYYPzZZk> MlrOO|IhcA>? NEPSNZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RzIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFIxLSCIQmOsJGlEPTB;MUSuN{DPxE1? NEXzWGMzOjlyMUi5OS=>
MSTO-211H cells NFz0bYJRem:uaX\ldoF1cW:wIHHzd4F6 M2fKUVczKGh? M1\k[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTWPUU{0zOTGKIHPlcIx{KGGodHXyJFczKGi{czDifUB1enmyYX6gZox2\SCjc4PhfUwhUUN3ME2yN{4{KM7:TR?= MnLONlM4OzV6Mkm=
HepG2 cells M4HHRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\rPGx1OjRiaB?= MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgR4VtdFSrdHXyMWJtfWWFZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mz60{txO M4jMXlIxPTR3M{O0
KIF5 cells M4iyZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXjmUJRwOjRiaB?= MW\Uc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN MV[yNlc4PTR5NB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Pdx1PB-CreERTm mice
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Water Insoluble
Ethanol ''74 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474
Smiles CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04174352 Suspended Drug: Tamoxifen|Diagnostic Test: FES PET/CT ERα+ Breast Cancer|ESR1 Gene Mutation University of Wisconsin Madison June 2020 Early Phase 1
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester February 1 2020 Phase 1
NCT04312347 Recruiting Drug: Tamoxifen dose adjustment ER+ Breast Cancer Nalagenetics Pte Ltd September 6 2019 Not Applicable
NCT03582865 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer Assiut University September 1 2019 --
NCT02801786 Not yet recruiting Drug: Placebo|Drug: Lidocaine|Drug: Tamoxifen Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Tags: buy Tamoxifen | Tamoxifen ic50 | Tamoxifen price | Tamoxifen cost | Tamoxifen solubility dmso | Tamoxifen purchase | Tamoxifen manufacturer | Tamoxifen research buy | Tamoxifen order | Tamoxifen mouse | Tamoxifen chemical structure | Tamoxifen mw | Tamoxifen molecular weight | Tamoxifen datasheet | Tamoxifen supplier | Tamoxifen in vitro | Tamoxifen cell line | Tamoxifen concentration | Tamoxifen nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID