Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MkTOSpVv[3Srb36gZZN{[Xl? NVu2V4ZJTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFXDOVA:OC5yMTFOwG0> MnGyNVI5OjV7M{W=
MCF7 cells NVroTpdqS3m2b4TvfIlkcXS7IHHzd4F6 NE\vdJE1QCCq M4K1ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlAzPyEQvF2= MnnNNlI1PzJyNEW=
Ishikawa cells NF;WXmFHfW6ldHnvckBie3OjeR?= NXPYdW1ES2:wY3XueJJifGmxbjDv[kBkd22yb4Xu[EBz\XG3aYLl[EB1dyCrbnT1Z4UhPTBiJTDv[kB1cGVibXH4bY12dSC|dHnteYxifGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCjY4Tpeol1gSCrbjDJd4hqc2G5YTDj[YxteyxiRVO1NF0xNjB|MzFOwG0> Mlv6PFIxOTV6Nx?=
HEK293T cells MYnGeY5kfGmxbjDhd5NigQ>? M4XDRWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> MkW3NlM4QDZ2NUK=
MDA-MB-435 cells M1XL[WZ2dmO2aX;uJIF{e2G7 NHLaT2lKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> MYKxOFk4OTh7OR?=
MDA-MB-231 cells MWnGeY5kfGmxbjDhd5NigQ>? NYL1UW56UW6qaXLpeIlwdiCxZjDld5Rzd2enbjDy[YNmeHSxcjDu[YdifGm4ZTDNSGEuVUJvMkOxJIJz\WG|dDDjZY5k\XJiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEig{txO MYqxOFk4OTh7OR?=
T47D cells MXzGeY5kfGmxbjDhd5NigQ>? NGLC[mhCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDUOFdFKGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5Ih[XO|ZYPz[YQh[XNiZYP0do9o\W5vZHXw[Y5l\W62IITyZY5{[3KrcITpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNUDPxE1? M{TFelE6OTNzMkS4
Ishikawa cells Mo\rSpVv[3Srb36gZZN{[Xl? M4\M[|czKGh? NHvCWGRCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQh[WytYXzpcoUheGixc4DoZZRie2ViYXP0bZZqfHliYX\0[ZIhPzJiaILzMEBKSzVyPUCuNVch|ryP NFO3fpAyQDh|NUG3Oi=>
MCF-7-2a cells MYPGeY5kfGmxbjDhd5NigQ>? MmDvRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gUWNHNTdvMnGgZ4VtdHNiYYOgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2ViZYP0doFlcW:uIHXm[oVkfCCkeTC1NEUtKEmFNUC9NE42KM7:TR?= NXrSZ5BOOTJ2M{GwOlM>
EL4 cell NF\FXHNRem:uaX\ldoF1cW:wIHHzd4F6 MYLJcohq[mm2aX;uJI9nKFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCrboTvJGVNPCClZXzsJJBzd2yrZnXyZZRqd25uIHnjOVA:OC53M{Wg{txO M2jOV|E2PzN4M{C=
HeLa cells MlPMSpVv[3Srb36gZZN{[Xl? NWLWblRmUW6qaXLpeIlwdiCxZjCxO{1j\XSjLXXzeJJi\GmxbDDt[YRq[XSnZDDseYNq\mW{YYPlJJRz[W6|Y4LpdJRqd25iaX6gTIVN[SClZXzsd{BmgHC{ZYPzbY5oKGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijOzDFVmUh[XO|YYmsJGlEPTB;MD62NlIh|ryP MY[xOVY2QDh3MR?=
MDA-MB-231 cells Mn7ZVJJwdGmoZYLheIlwdiCjc4PhfS=> MoLkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[2JO69VQ>? M4\D[|IxPDVzM{iw
T47D cells NIjJSVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFvDUnk4OiCq NH;OcVBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBme3S{b3flck1l\XCnbnTlcpQhXDR5RDDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MTFOwG0> M{H2O|E6OTNzMkS4
yeast AH109 cells MVHGeY5kfGmxbjDhd5NigQ>? NFfMRY8zPCCq M1LxfmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLi[ZRiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBqdnSncnHjeIlwdiC5aYToJHNTSzFiYX\0[ZIhOjRiaILzJIJ6KGGucHjhMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9NU43PiEQvF2= Mnv4NlI3PDd{MUe=
GBM2 cells MUDQdo9tcW[ncnH0bY9vKGG|c3H5 MXO3NkBp MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME2zMlUh|ryP MUCyOlM2PTV|Mh?=
NCI-H460 cells NWi3ZmJQTnWwY4Tpc44h[XO|YYm= NGXWZoczPCCq MYDBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= MknTNVk4OzNyOEW=
GBM3 cells Ml7VVJJwdGmoZYLheIlwdiCjc4PhfS=> NUPObG5UPzJiaB?= MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME20Mlch|ryP MoTzNlY{PTV3M{K=
DLD1 cells NWDUUGNIS3m2b4TvfIlkcXS7IHHzd4F6 MVy5OkBp MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND63PEDPxE1? NFnkNJUzOjd2OUO5Ni=>
ScN2a-cl3 cells Ml;kR5l1d3SxeHnjbZR6KGG|c3H5 MX[1JIRigXN? NVK1XGt5S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4Uh\Gm4aXTpcochW2OQMnGtZ4w{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEWg[IF6eyCkeTDjZYxk\WmwLVHNJJN1[WmwaX7nMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD12Lki5JO69VQ>? M2nsOVI1OTh|NUi5
K562 cells M2OyUHBzd2yrZnXyZZRqd25iYYPzZZk> M4PHT|czKGh? MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? M4ftSlI2PDJyMUe1
MDA-MB-435S cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= M1i2VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|VUKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDhd5NigSxiSVO1NF02NjVizszN MmTvNlYxPzlyOUC=
DU145 cells MonpVJJwdGmoZYLheIlwdiCjc4PhfS=> NH3wUVQ1QCCq MoPMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNTFOwG0> MVWyN|I5PzB3Nx?=
HepG2 cells NHPXSndRem:uaX\ldoF1cW:wIHHzd4F6 NVPQZ2hpPDhiaB?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi5|IN88US=> MW[yN|I5PzB3Nx?=
SKOV3 cells NET5V4hHfW6ldHnvckBie3OjeR?= M3XJTVI1KGh? NHn5TFhCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME22MlQh|ryP MV[xPVc{OzB6NR?=
PC3 cells M1zKdHBzd2yrZnXyZZRqd25iYYPzZZk> MmiwNlQhcA>? NI\Ub2dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTdizszN NVvuWVRpOjR6OECyN|A>
NIH/3T3 cells NGC3bFJEgXSxdH;4bYNqfHliYYPzZZk> NHXDR|E6PiCq MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{4zPiEQvF2= NHzXNIUzOjd2OUO5Ni=>
GBM1 cells NEjFSWRRem:uaX\ldoF1cW:wIHHzd4F6 M1:5OlczKGh? M3\lemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVcvPSEQvF2= MkLNNlY{PTV3M{K=
518A2 cells MljqR5l1d3SxeHnjbZR6KGG|c3H5 MXS5OkBp NYDvcJFzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjZ{IN88US=> NF;IfIEzOjd2OUO5Ni=>
A2780 cells NEL1TnZEgXSxdH;4bYNqfHliYYPzZZk> M3PIeFk3KGh? MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuO|ch|ryP NFTid4ozOjd2OUO5Ni=>
A549 cells MkLDR5l1d3SxeHnjbZR6KGG|c3H5 NHe1WpNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OD16LkSg{txO MYSyOlA4QTB7MB?=
Lipo cells NGCxSYJEgXSxdH;4bYNqfHliYYPzZZk> MVK5OkBp NUH1TVVjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN MX6yNlc1QTN7Mh?=
A253 cells MlPKR5l1d3SxeHnjbZR6KGG|c3H5 MWG5OkBp M{T3cWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= NVGzOG5NOjJ5NEmzPVI>
HT-29 cells MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHnRfVBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJXC1{OTDj[YxteyxiSVO1NF06NjVizszN NE\oSW8zOzRyM{C4OC=>
LNCAP cells NEXnZWFRem:uaX\ldoF1cW:wIHHzd4F6 Moi4OFghcA>? M4rr[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTF7DRXAh[2WubIOg[ZhxemW|c3nu[{BidmS{b3flckBz\WOncITvdkBqdmO3YnH0[YQhf2m2aDCwMlYhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkegcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwQVExKM7:TR?= NEjzTWUzOTVzM{K3OS=>
M21 cells MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MljNS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVIyKGOnbHzzMEBKSzVyPUGxJO69VQ>? NWnzO|A4OjN2MEOwPFQ>
850C cells NVTEW3dyS3m2b4TvfIlkcXS7IHHzd4F6 MXW5OkBp MnPjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxSyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGxMlA6KM7:TR?= NY[0TIVDOjJ5NEmzPVI>
HL60 cells Ml7XR5l1d3SxeHnjbZR6KGG|c3H5 M1rJOlczKGh? MlzvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVOSCjc4PhfUBqdiCycnXz[Y5k\SCxZjCyNEUhTkKVLDDJR|UxRTF2LkOg{txO NYD1W3J4OjJ7MEG4PVU>
MSTO-211H cells MkDiVJJwdGmoZYLheIlwdiCjc4PhfS=> NGXKNm44OiCq MofXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPU2TPMVIyOUhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJRzgXCjbjDicJVmKGG|c3H5MEBKSzVyPUKzMlMh|ryP MmHTNlM4OzV6Mkm=
HepG2 cells M{eyd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYCyOEBp NIXRTlFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhS2WubGTpeIVzNUKudXXD[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{41|ryP MnrwNlA2PDV|M{S=
KIF5 cells Mn3DR5l1d3SxeHnjbZR6KGG|c3H5 NIrFRVAzPCCq NUn0WppRXG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLTWY2KGOnbHzzJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IFPlcIxVcXSncjDCcJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|Lke1JO69VQ>? M2TuSFIzPzd3NEe0

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03423199 Recruiting Breast Neoplasms National Cancer Center Japan|Pfizer|Korean Cancer Study Group February 9 2018 Phase 3
NCT02089386 Terminated Barrett Metaplasia Washington University School of Medicine July 9 2014 Early Phase 1
NCT00026585 Completed Bipolar Disorder National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) November 9 2001 Phase 2
NCT02824224 Completed Menorrhagia|Metrorrhagia|Medicated Intrauterine Devices Oregon Health and Science University September 6 2016 Phase 4
NCT02311933 Active not recruiting Estrogen Receptor Positive|HER2/Neu Negative|Recurrent Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7 National Cancer Institute (NCI) March 6 2015 Phase 2
NCT01582074 Completed Breast Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 5 2011 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID