Tamoxifen

For research use only. Not for use in humans.

Catalog No.S1238 Synonyms: ICI 46474

19 publications

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

Size Price Stock Quantity  
USD 147 In stock
USD 297 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Tamoxifen has been cited by 19 publications

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MXTGeY5kfGmxbjDhd5NigQ>? NIHlXGNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> NGfNdVUyOjh{NUmzOS=>
MCF7 cells NGDXZpREgXSxdH;4bYNqfHliYYPzZZk> M3vRUlQ5KGh? NWLPdphHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ5IN88US=> MlPvNlI1PzJyNEW=
Ishikawa cells NF33VHlHfW6ldHnvckBie3OjeR?= M4DoS2NwdmOnboTyZZRqd25ib3[gZ49ueG:3bnSgdoVyfWm{ZXSgeI8hcW6mdXPlJFUxKCVib3[geIhmKG2jeHnteY0he3SrbYXsZZRqd25ib3[gZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkhcW5iSYPobYtif2FiY3XscJMtKEWFNUC9NE4xOzNizszN MkjUPFIxOTV6Nx?=
HEK293T cells MofuSpVv[3Srb36gZZN{[Xl? MX7BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEejbESgSGJFNW[3c3XkJIh2dWGwIFXSZYxxcGFiTFLEJIV5eHKnc4Pl[EBqdiCKRVuyPVNVKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[g[ZN1emGmaX;sMYlv\HWlZXSgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZYZ1\XJiMkCgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlA{QSEQvF2= NHHiSFAzOzd6NkS1Ni=>
MDA-MB-435 cells MoO0SpVv[3Srb36gZZN{[Xl? NITIWGtKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> M1TGWVE1QTdzOEm5
MDA-MB-231 cells MnPmSpVv[3Srb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGW|dILv[4VvKHKnY3XweI9zKG6nZ3H0bZZmKE2GQT3NRk0zOzFiYoLlZZN1KGOjbnPldkBk\WyuIIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xQCEQvF2= NYTF[XVHOTR7N{G4PVk>
T47D cells MlPnSpVv[3Srb36gZZN{[Xl? NFuxOFhCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDUOFdFKGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5Ih[XO|ZYPz[YQh[XNiZYP0do9o\W5vZHXw[Y5l\W62IITyZY5{[3KrcITpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNUDPxE1? MV2xPVE{OTJ2OB?=
Ishikawa cells MWPGeY5kfGmxbjDhd5NigQ>? MmfCO|IhcA>? MmDNRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{b3flck1qdmS3Y3XkJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGGodHXyJFczKGi{czygTWM2OD1yLkG3JO69VQ>? NVOx[WoyOTh6M{WxO|Y>
MCF-7-2a cells M3fseGZ2dmO2aX;uJIF{e2G7 MWXBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDNR2YuPy1{YTDj[YxteyCjczDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SCnc4TyZYRqd2xiZX\m[YN1KGK7IEWwKUwhUUN3ME2wMlUh|ryP NGjqV4YyOjR|MUC2Ny=>
EL4 cell NIP6OoFRem:uaX\ldoF1cW:wIHHzd4F6 NVfE[lA1UW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= M{CxNlE2PzN4M{C=
HeLa cells NUf4U41RTnWwY4Tpc44h[XO|YYm= NXfq[pR5UW6qaXLpeIlwdiCxZjCxO{1j\XSjLXXzeJJi\GmxbDDt[YRq[XSnZDDseYNq\mW{YYPlJJRz[W6|Y4LpdJRqd25iaX6gTIVN[SClZXzsd{BmgHC{ZYPzbY5oKGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijOzDFVmUh[XO|YYmsJGlEPTB;MD62NlIh|ryP MoflNVU3PTh6NUG=
MDA-MB-231 cells MVPQdo9tcW[ncnH0bY9vKGG|c3H5 MmTYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[2JO69VQ>? NUO0[VB7OjB2NUGzPFA>
T47D cells MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEjxeHo4OiCq NHfxO4lIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBme3S{b3flck1l\XCnbnTlcpQhXDR5RDDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MTFOwG0> NV;DSGl7OTlzM{GyOFg>
yeast AH109 cells M1:4fWZ2dmO2aX;uJIF{e2G7 MmTONlQhcA>? M1\YZ2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLi[ZRiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBqdnSncnHjeIlwdiC5aYToJHNTSzFiYX\0[ZIhOjRiaILzJIJ6KGGucHjhMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9NU43PiEQvF2= MV:yNlY1PzJzNx?=
GBM2 cells MnLFVJJwdGmoZYLheIlwdiCjc4PhfS=> NGDxdo04OiCq MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME2zMlUh|ryP NXr4fHVLOjZ|NUW1N|I>
NCI-H460 cells M3rwc2Z2dmO2aX;uJIF{e2G7 NX7sPWVmOjRiaB?= M3jjfmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPDhizszN MonxNVk4OzNyOEW=
GBM3 cells MX;Qdo9tcW[ncnH0bY9vKGG|c3H5 MmTBO|IhcA>? Ml7lRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJQl2zJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDXV3QuOSCvZYToc4QtKEmFNUC9OE44KM7:TR?= NHTuWpgzPjN3NUWzNi=>
DLD1 cells MWPDfZRwfG:6aXPpeJkh[XO|YYm= NIPTdlA6PiCq MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND63PEDPxE1? NUjYUXRrOjJ5NEmzPVI>
ScN2a-cl3 cells MUjDfZRwfG:6aXPpeJkh[XO|YYm= MnXOOUBl[Xm| NHyxNldEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBlcX[rZHnu[{BU[05{YT3jcFMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNTDkZZl{KGK7IHPhcINmcW5vQV2gd5RicW6rbnetZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTRwOEmg{txO M3Hod|I1OTh|NUi5
K562 cells Ml2yVJJwdGmoZYLheIlwdiCjc4PhfS=> M3G2NVczKGh? MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? MoHRNlU1OjBzN{W=
MDA-MB-435S cells MnjSR5l1d3SxeHnjbZR6KGG|c3H5 Mlz2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZpkhVVSWIHHzd4F6NCCLQ{WwQVUvPSEQvF2= MY[yOlA4QTB7MB?=
DU145 cells NX\jS3A4WHKxbHnm[ZJifGmxbjDhd5NigQ>? MVK0PEBp NWm0V4lLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUWuOUDPxE1? M1HmeFI{Ojh5MEW3
HepG2 cells M2WwZ3Bzd2yrZnXyZZRqd25iYYPzZZk> NFzvTFQ1QCCq NVvyNo1JSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPU[uN{DPxE1? MXeyN|I5PzB3Nx?=
SKOV3 cells NHO1SWpHfW6ldHnvckBie3OjeR?= NF3relEzPCCq M4nEd2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPU[uOEDPxE1? M{LGdFE6PzN|MEi1
PC3 cells NFr6UGpRem:uaX\ldoF1cW:wIHHzd4F6 MlvyNlQhcA>? NXjWeJVHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD15IN88US=> MYOyOFg5ODJ|MB?=
NIH/3T3 cells MXXDfZRwfG:6aXPpeJkh[XO|YYm= MUm5OkBp NVvWUXFJS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTdwMk[g{txO NH7TfXAzOjd2OUO5Ni=>
GBM1 cells NF[zT5JRem:uaX\ldoF1cW:wIHHzd4F6 M2XOelczKGh? NWrkOHlVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHRm0yKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBYW1RvMTDt[ZRpd2RuIFnDOVA:Py53IN88US=> MY[yOlM2PTV|Mh?=
518A2 cells NIPpbpZEgXSxdH;4bYNqfHliYYPzZZk> M3fheVk3KGh? NHT3TldEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA2OTiDMjDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvPjJizszN M2XUSlIzPzR7M{my
A2780 cells NX6zSnF1S3m2b4TvfIlkcXS7IHHzd4F6 NYrETWN{QTZiaB?= MmLOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23Mlc4KM7:TR?= NUj3PIdQOjJ5NEmzPVI>
A549 cells NYTTe4JMS3m2b4TvfIlkcXS7IHHzd4F6 NGrlOHhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OD16LkSg{txO NWD4XnR2OjZyN{mwPVA>
Lipo cells NFzvdmREgXSxdH;4bYNqfHliYYPzZZk> MlLxPVYhcA>? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMbZBwKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;OD62OEDPxE1? NYXq[JhXOjJ5NEmzPVI>
A253 cells M3rqXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGXBO|c6PiCq MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlU{KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;OD65NkDPxE1? MUSyNlc1QTN7Mh?=
HT-29 cells NVj6fFdtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\xS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTHQuOjliY3XscJMtKEmFNUC9PU42KM7:TR?= NYD6O5hOOjN2MEOwPFQ>
LNCAP cells M2LH[XBzd2yrZnXyZZRqd25iYYPzZZk> NHLHb3M1QCCq NFn0UlJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIV5eHKnc4Ppcoch[W6mcn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE43KG6PIH;mJIV{fHKjZHnvcEBidmRiMD63JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0yOCEQvF2= MWGyNVUyOzJ5NR?=
M21 cells M1vQU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX62b5BVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTJzIHPlcIx{NCCLQ{WwQVEyKM7:TR?= NWrS[XlsOjN2MEOwPFQ>
850C cells MVPDfZRwfG:6aXPpeJkh[XO|YYm= MnHwPVYhcA>? NW\hR3hGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDVyQzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEyNjB7IN88US=> NW\hTZg1OjJ5NEmzPVI>
HL60 cells M2fHdmN6fG:2b4jpZ4l1gSCjc4PhfS=> NY\SdlF7PzJiaB?= NFrqSW1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RzIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFIxLSCIQmOsJGlEPTB;MUSuN{DPxE1? MlSwNlI6ODF6OUW=
MSTO-211H cells NIjnWohRem:uaX\ldoF1cW:wIHHzd4F6 NGfFS3Q4OiCq MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2VVF:tNlEyUCClZXzsd{Bi\nSncjC3NkBpenNiYomgeJJ6eGGwIHLseYUh[XO|YYmsJGlEPTB;MkOuN{DPxE1? MVKyN|c{PTh{OR?=
HepG2 cells NGDGZ3FEgXSxdH;4bYNqfHliYYPzZZk> MVGyOEBp NWDLRZhJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KEOnbHzUbZRmei2EbIXlR4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPM7:TR?= NInCUpIzODV2NUOzOC=>
KIF5 cells Ml;nR5l1d3SxeHnjbZR6KGG|c3H5 NHfzPJczPCCq MkLGWI95cWOrdImgZYdicW6|dDDoeY1idiCNSV[1JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KEOnbHzUbZRmeiCEbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{Njd3IN88US=> MV[yNlc4PTR5NB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474
Smiles CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03582865 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer Assiut University September 1 2019 --
NCT02801786 Not yet recruiting Drug: Placebo|Drug: Lidocaine|Drug: Tamoxifen Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3
NCT03707340 Recruiting Drug: Flibanserin Pill Breast Cancer|Hyposexual Desire Disorder Memorial Sloan Kettering Cancer Center September 14 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

Related Estrogen/progestogen Receptor Products

Tags: buy Tamoxifen | Tamoxifen ic50 | Tamoxifen price | Tamoxifen cost | Tamoxifen solubility dmso | Tamoxifen purchase | Tamoxifen manufacturer | Tamoxifen research buy | Tamoxifen order | Tamoxifen mouse | Tamoxifen chemical structure | Tamoxifen mw | Tamoxifen molecular weight | Tamoxifen datasheet | Tamoxifen supplier | Tamoxifen in vitro | Tamoxifen cell line | Tamoxifen concentration | Tamoxifen nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID