Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M1T5UGZ2dmO2aX;uJIF{e2G7 NHP5SmlG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> MWCxNlgzPTl|NR?=
MCF7 cells M1zDNGN6fG:2b4jpZ4l1gSCjc4PhfS=> MoTEOFghcA>? NVPyUGhoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ5IN88US=> NYqwbYlkOjJ2N{KwOFU>
Ishikawa cells M3rISGZ2dmO2aX;uJIF{e2G7 M3fidWNwdmOnboTyZZRqd25ib3[gZ49ueG:3bnSgdoVyfWm{ZXSgeI8hcW6mdXPlJFUxKCVib3[geIhmKG2jeHnteY0he3SrbYXsZZRqd25ib3[gZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkhcW5iSYPobYtif2FiY3XscJMtKEWFNUC9NE4xOzNizszN MX24NlAyPTh5
HEK293T cells NYThN3BRTnWwY4Tpc44h[XO|YYm= M4S1bmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> NV64bYRpOjN5OE[0OVI>
MDA-MB-435 cells M4rVZ2Z2dmO2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKE2GQT3NRk01OzViYoLlZZN1KGOjbnPldkBk\WyuIIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xPSEQvF2= M1ztRlE1QTdzOEm5
MDA-MB-231 cells NFficldHfW6ldHnvckBie3OjeR?= MX;Jcohq[mm2aX;uJI9nKGW|dILv[4VvKHKnY3XweI9zKG6nZ3H0bZZmKE2GQT3NRk0zOzFiYoLlZZN1KGOjbnPldkBk\WyuIIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xQCEQvF2= M4HqdVE1QTdzOEm5
T47D cells MWXGeY5kfGmxbjDhd5NigQ>? Mk\yRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iVES3SEBk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIF{e2W|c3XkJIF{KGW|dILv[4VvNWSncHXu[IVvfCC2cnHud4NzcXC2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkGg{txO M132XFE6OTNzMkS4
Ishikawa cells M2q0W2Z2dmO2aX;uJIF{e2G7 NV;2V4h{PzJiaB?= MlLQRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{b3flck1qdmS3Y3XkJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGGodHXyJFczKGi{czygTWM2OD1yLkG3JO69VQ>? M1fiOlE5QDN3MUe2
MCF-7-2a cells MofUSpVv[3Srb36gZZN{[Xl? NFjVOYpCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBOS0ZvNz2yZUBk\WyuczDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDld5Rz[WSrb3yg[YZn\WO2IHL5JFUxLSxiSVO1NF0xNjVizszN NWmwOnJCOTJ2M{GwOlM>
EL4 cell MVfQdo9tcW[ncnH0bY9vKGG|c3H5 NVu3SWFTUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= MlfFNVU4OzZ|MB?=
HeLa cells NXz4XnR5TnWwY4Tpc44h[XO|YYm= M1PWSGlvcGmkaYTpc44hd2ZiMUetZoV1[S2nc4TyZYRqd2xibXXkbYF1\WRibIXjbYZmemG|ZTD0doFve2O{aYD0bY9vKGmwIFjlUIEh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDhcJBp[TtiRWLFJIF{e2G7LDDJR|UxRTBwNkKyJO69VQ>? MVyxOVY2QDh3MR?=
MDA-MB-231 cells M1S2RnBzd2yrZnXyZZRqd25iYYPzZZk> Mlz4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[2JO69VQ>? NV\iVpk1OjB2NUGzPFA>
T47D cells M3znUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIDBfG04OiCq NWrzXopZT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h\XO2cn;n[Y4u\GWyZX7k[Y51KFR2N1SgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGg{txO NX7PNZV2OTlzM{GyOFg>
yeast AH109 cells NE\PN5NHfW6ldHnvckBie3OjeR?= MYGyOEBp MUTBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYnX0ZUBz\WOncITvdkBNSkRiZYjwdoV{e2WmIHnuJJlm[XO2IFHINVA6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gbY51\XKjY4Tpc44hf2m2aDDTVmMyKGGodHXyJFI1KGi{czDifUBidHCqYT3nZYxi[3Sxc3nkZZNmKGG|c3H5MEBKSzVyPUGuOlYh|ryP NYTSU4E2OjJ4NEeyNVc>
GBM2 cells Mn;ZVJJwdGmoZYLheIlwdiCjc4PhfS=> NUDlNXZLPzJiaB?= NFPMNWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF0{NjVizszN NX;zUYVWOjZ|NUW1N|I>
NCI-H460 cells M2TJXWZ2dmO2aX;uJIF{e2G7 MkjxNlQhcA>? Mn7YRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyIHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE41QCEQvF2= NG\m[|YyQTd|M{C4OS=>
GBM3 cells MXfQdo9tcW[ncnH0bY9vKGG|c3H5 NH3zWok4OiCq MoG0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJQl2zJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDXV3QuOSCvZYToc4QtKEmFNUC9OE44KM7:TR?= M3jReVI3OzV3NUOy
DLD1 cells MXfDfZRwfG:6aXPpeJkh[XO|YYm= NFLjfng6PiCq NHzPVVhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFVERzIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE44QCEQvF2= MnSxNlI4PDl|OUK=
ScN2a-cl3 cells MYfDfZRwfG:6aXPpeJkh[XO|YYm= MXi1JIRigXN? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDkbZZq\GmwZzDTZ24z[S2lbEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPSCmYYnzJIJ6KGOjbHPlbY4uSU1ic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVQvQDlizszN MYWyOFE5OzV6OR?=
K562 cells MYXQdo9tcW[ncnH0bY9vKGG|c3H5 NW[4eph5PzJiaB?= MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NWj6b5lqOjV2MkCxO|U>
MDA-MB-435S cells NWC5XYVUS3m2b4TvfIlkcXS7IHHzd4F6 NYLvUYRUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PVNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7LDDJR|UxRTVwNTFOwG0> MWGyOlA4QTB7MB?=
DU145 cells NHPCUldRem:uaX\ldoF1cW:wIHHzd4F6 NWPj[JZtPDhiaB?= MmfxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNTFOwG0> NVTwTpRVOjN{OEewOVc>
HepG2 cells NVHkXWJbWHKxbHnm[ZJifGmxbjDhd5NigQ>? MmPnOFghcA>? NIfMUlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Nj6zJO69VQ>? M{i1PVI{Ojh5MEW3
SKOV3 cells NIC1W5NHfW6ldHnvckBie3OjeR?= MmfRNlQhcA>? NHP2RotCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME22MlQh|ryP NG\2bGEyQTd|M{C4OS=>
PC3 cells MnvTVJJwdGmoZYLheIlwdiCjc4PhfS=> MYKyOEBp Ml;vRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF04KM7:TR?= NEDNdlUzPDh6MEKzNC=>
NIH/3T3 cells Ml7aR5l1d3SxeHnjbZR6KGG|c3H5 M1S3U|k3KGh? NYHCcXhHS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTdwMk[g{txO MX[yNlc1QTN7Mh?=
GBM1 cells M3X4bHBzd2yrZnXyZZRqd25iYYPzZZk> Ml7EO|IhcA>? M1ruTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVcvPSEQvF2= M4jpOFI3OzV3NUOy
518A2 cells M{jWOmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1W1cVk3KGh? NVvKTmM4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjZ{IN88US=> MoDrNlI4PDl|OUK=
A2780 cells MV7DfZRwfG:6aXPpeJkh[XO|YYm= MWC5OkBp MmP0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23Mlc4KM7:TR?= NFLBc20zOjd2OUO5Ni=>
A549 cells MUPDfZRwfG:6aXPpeJkh[XO|YYm= M1v4XGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7LDDJR|UxRThwNDFOwG0> NIrxXpozPjB5OUC5NC=>
Lipo cells NXHyWWxlS3m2b4TvfIlkcXS7IHHzd4F6 Mlf0PVYhcA>? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMbZBwKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;OD62OEDPxE1? MlTNNlI4PDl|OUK=
A253 cells MmH6R5l1d3SxeHnjbZR6KGG|c3H5 M4HqcVk3KGh? M3\yUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= MnnDNlI4PDl|OUK=
HT-29 cells NH;QRZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\Ldmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIx{NCCLQ{WwQVkvPSEQvF2= M2naTVI{PDB|MEi0
LNCAP cells M4DnbHBzd2yrZnXyZZRqd25iYYPzZZk> NGDiSpc1QCCq NEDwXZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIV5eHKnc4Ppcoch[W6mcn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE43KG6PIH;mJIV{fHKjZHnvcEBidmRiMD63JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0yOCEQvF2= NFH1N4YzOTVzM{K3OS=>
M21 cells NV3UVo5jT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3yS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVIyKGOnbHzzMEBKSzVyPUGxJO69VQ>? MViyN|QxOzB6NB?=
850C cells M3zzZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoPhPVYhcA>? M3LVR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFg2OENiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNU4xQSEQvF2= NH;a[3ozOjd2OUO5Ni=>
HL60 cells NIXzXXZEgXSxdH;4bYNqfHliYYPzZZk> MkezO|IhcA>? NVK5dIFRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhX1OWMTDhd5NigSCrbjDwdoV{\W6lZTDv[kAzOCViRlLTMEBKSzVyPUG0MlMh|ryP NH\LPXkzOjlyMUi5OS=>
MSTO-211H cells MlPUVJJwdGmoZYLheIlwdiCjc4PhfS=> M17nWlczKGh? NVLZVHFJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNV3RQNTJzMVigZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDhckBjdHWnIHHzd4F6NCCLQ{WwQVI{NjNizszN NUTQW2E{OjN5M{W4Nlk>
HepG2 cells NFnHenlEgXSxdH;4bYNqfHliYYPzZZk> NUHpZlFQOjRiaB?= MlXNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNmdGyWaYTldk1DdHWnQ3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOO69VQ>? NYSwbmFHOjB3NEWzN|Q>
KIF5 cells NGnoWZFEgXSxdH;4bYNqfHliYYPzZZk> NWjL[Ho4OjRiaB?= MXnUc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN NVfrb4JQOjJ5N{W0O|Q>

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03423199 Recruiting Breast Neoplasms National Cancer Center Japan|Pfizer|Korean Cancer Study Group February 9 2018 Phase 3
NCT02089386 Terminated Barrett Metaplasia Washington University School of Medicine July 9 2014 Early Phase 1
NCT00026585 Completed Bipolar Disorder National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) November 9 2001 Phase 2
NCT02824224 Completed Menorrhagia|Metrorrhagia|Medicated Intrauterine Devices Oregon Health and Science University September 6 2016 Phase 4
NCT02311933 Active not recruiting Estrogen Receptor Positive|HER2/Neu Negative|Recurrent Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7 National Cancer Institute (NCI) March 6 2015 Phase 2
NCT01582074 Completed Breast Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 5 2011 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID