Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MnrYSpVv[3Srb36gZZN{[Xl? M4LhNGVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiTVPGMVch[nKnYYP0JJR2dW:{IHPlcIx{KHW|aX7nJG1ETi15IHHzd4F6NCCHQ{WwQVAvODFizszN MVWxNlgzPTl|NR?=
MCF7 cells MnLrR5l1d3SxeHnjbZR6KGG|c3H5 M{XHclQ5KGh? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wNlch|ryP NUewd|U2OjJ2N{KwOFU>
Ishikawa cells NYHZOWJETnWwY4Tpc44h[XO|YYm= NFn6XoZEd26lZX70doF1cW:wIH;mJINwdXCxdX7kJJJmeXWrcnXkJJRwKGmwZIXj[UA2OCBnIH;mJJRp\SCvYYjpcZVuKHO2aX31cIF1cW:wIH;mJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGmwIFnzbIls[XejIHPlcIx{NCCHQ{WwQVAvODN|IN88US=> Mn;xPFIxOTV6Nx?=
HEK293T cells MmnZSpVv[3Srb36gZZN{[Xl? MVPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEejbESgSGJFNW[3c3XkJIh2dWGwIFXSZYxxcGFiTFLEJIV5eHKnc4Pl[EBqdiCKRVuyPVNVKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[g[ZN1emGmaX;sMYlv\HWlZXSgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZYZ1\XJiMkCgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlA{QSEQvF2= NXnYV5V3OjN5OE[0OVI>
MDA-MB-435 cells M1jnd2Z2dmO2aX;uJIF{e2G7 NEPQNGRKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> NF7aSGQyPDl5MUi5PS=>
MDA-MB-231 cells NWPKUXRwTnWwY4Tpc44h[XO|YYm= NEjzNXpKdmirYnn0bY9vKG:oIHXzeJJw\2WwIILlZ4VxfG:{IH7l[4F1cX[nIF3ERU1OSi1{M{GgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yODFOwG0> Mn;HNVQ6PzF6OUm=
T47D cells NHnFcIVHfW6ldHnvckBie3OjeR?= M2TseWFvfGmnc4Tyc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIGS0O2Qh[2WubIOg[ZhxemW|c3nu[{Bme3S{b3flckBz\WOncITvdkBie3Onc4Pl[EBieyCnc4Tyc4dmdi2mZYDlcoRmdnRidILhcpNkemmydHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6xJO69VQ>? NYe0PWh7OTlzM{GyOFg>
Ishikawa cells MYPGeY5kfGmxbjDhd5NigQ>? NGrjOnQ4OiCq MYnBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCLc3jpb4F4[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKxZ3XuMYlv\HWlZXSgZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwMUeg{txO NVvZUHl{OTh6M{WxO|Y>
MCF-7-2a cells Mlm1SpVv[3Srb36gZZN{[Xl? MWnBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDNR2YuPy1{YTDj[YxteyCjczDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SCnc4TyZYRqd2xiZX\m[YN1KGK7IEWwKUwhUUN3ME2wMlUh|ryP NWPkWItROTJ2M{GwOlM>
EL4 cell M4\qPXBzd2yrZnXyZZRqd25iYYPzZZk> NUXKPW1wUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= NFjSbHQyPTd|NkOw
HeLa cells NHPXT2FHfW6ldHnvckBie3OjeR?= MYPJcohq[mm2aX;uJI9nKDF5LXLleIEu\XO2cnHkbY9tKG2nZHnheIVlKGy3Y3nm[ZJie2VidILhcpNkemmydHnvckBqdiCKZVzhJINmdGy|IHX4dJJme3OrbnegbJVu[W5iZYP0do9o\W5icnXj[ZB1d3JiYXzwbIE8KEWURTDhd5NigSxiSVO1NF0xNjZ{MjFOwG0> MonHNVU3PTh6NUG=
MDA-MB-231 cells Ml\YVJJwdGmoZYLheIlwdiCjc4PhfS=> NIjYb2NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOlYh|ryP NVX0d|QyOjB2NUGzPFA>
T47D cells MnjOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M363flczKGh? MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDld5Rzd2enbj3k[ZBmdmSnboSgWFQ4TCClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OSEQvF2= NHT4Wo4yQTF|MUK0PC=>
yeast AH109 cells MoTCSpVv[3Srb36gZZN{[Xl? NXnZeodUOjRiaB?= NVLLPIUzSW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoJmfGFicnXj[ZB1d3JiTFLEJIV5eHKnc4Pl[EBqdiC7ZXHzeEBCUDFyOTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGmwdHXyZYN1cW:wIIfpeIghW1KFMTDh[pRmeiB{NDDodpMh[nliYXzwbIEu\2GuYXP0c5Nq\GG|ZTDhd5NigSxiSVO1NF0yNjZ4IN88US=> M2\nOlIzPjR5MkG3
GBM2 cells M3PXN3Bzd2yrZnXyZZRqd25iYYPzZZk> MUK3NkBp M37hWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVMvPSEQvF2= MUiyOlM2PTV|Mh?=
NCI-H460 cells M4Prb2Z2dmO2aX;uJIF{e2G7 NHzDSmQzPCCq MUHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= NYD0UlZROTl5M{OwPFU>
GBM3 cells NVLxPZJzWHKxbHnm[ZJifGmxbjDhd5NigQ>? MkfQO|IhcA>? M4rYXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVQvPyEQvF2= MoTxNlY{PTV3M{K=
DLD1 cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= MVe5OkBp NUPncms3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEyGMTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPzhizszN NIHCeXYzOjd2OUO5Ni=>
ScN2a-cl3 cells NFTBZndEgXSxdH;4bYNqfHliYYPzZZk> NUjYTXJUPSCmYYnz NEHhWWZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBlcX[rZHnu[{BU[05{YT3jcFMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNTDkZZl{KGK7IHPhcINmcW5vQV2gd5RicW6rbnetZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTRwOEmg{txO M2XyPFI1OTh|NUi5
K562 cells NVPhbFVFWHKxbHnm[ZJifGmxbjDhd5NigQ>? NG\Cepg4OiCq NYHkd4NMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF02NjJizszN Mnj6NlU1OjBzN{W=
MDA-MB-435S cells NY\Wd3lsS3m2b4TvfIlkcXS7IHHzd4F6 MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDifUBOXFRiYYPzZZktKEmFNUC9OU42KM7:TR?= MlezNlYxPzlyOUC=
DU145 cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 NWS4bpg2PDhiaB?= M4WxVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13LkWg{txO M17K[VI{Ojh5MEW3
HepG2 cells NFXOeG5Rem:uaX\ldoF1cW:wIHHzd4F6 NEH4XJU1QCCq M{fWdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14LkOg{txO NGLvUlIzOzJ6N{C1Oy=>
SKOV3 cells M4HRT2Z2dmO2aX;uJIF{e2G7 NUDGZVNHOjRiaB?= NFjPb4tCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME22MlQh|ryP Ml\GNVk4OzNyOEW=
PC3 cells MnjyVJJwdGmoZYLheIlwdiCjc4PhfS=> MXeyOEBp NFvwbJZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTdizszN Ml\1NlQ5QDB{M{C=
NIH/3T3 cells MX7DfZRwfG:6aXPpeJkh[XO|YYm= NWr0V5BEQTZiaB?= M2nSR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjJ4IN88US=> MUSyNlc1QTN7Mh?=
GBM1 cells NYPSS5g3WHKxbHnm[ZJifGmxbjDhd5NigQ>? NYHTT3FiPzJiaB?= M3fGfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVcvPSEQvF2= Mof3NlY{PTV3M{K=
518A2 cells NV72OHhuS3m2b4TvfIlkcXS7IHHzd4F6 NUXGS48{QTZiaB?= M4\HcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFUyQEF{IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{43OiEQvF2= NWHUXVFFOjJ5NEmzPVI>
A2780 cells MljrR5l1d3SxeHnjbZR6KGG|c3H5 MknYPVYhcA>? MmLzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23Mlc4KM7:TR?= M3vtO|IzPzR7M{my
A549 cells Ml7TR5l1d3SxeHnjbZR6KGG|c3H5 MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDhd5NigSxiSVO1NF05NjRizszN M2Hx[|I3ODd7MEmw
Lipo cells M1HiTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXm5OkBp M1\KNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxqeG9iY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlY1KM7:TR?= MYOyNlc1QTN7Mh?=
A253 cells NGXDZWtEgXSxdH;4bYNqfHliYYPzZZk> MWS5OkBp M2jyWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= MWSyNlc1QTN7Mh?=
HT-29 cells NVvJfI56T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzYbmJ3T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMkmgZ4VtdHNuIFnDOVA:QS53IN88US=> M3jjUlI{PDB|MEi0
LNCAP cells NEf2eJRRem:uaX\ldoF1cW:wIHHzd4F6 M1TZXFQ5KGh? NFi1N3NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIV5eHKnc4Ppcoch[W6mcn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE43KG6PIH;mJIV{fHKjZHnvcEBidmRiMD63JI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0yOCEQvF2= NYfEb2MyOjF3MUOyO|U>
M21 cells NYnQSokyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIH0SY5Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOOjFiY3XscJMtKEmFNUC9NVEh|ryP NFrBbmozOzRyM{C4OC=>
850C cells NU[zcIpuS3m2b4TvfIlkcXS7IHHzd4F6 NXLG[|FlQTZiaB?= NFTq[5pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA5PTCFIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NVEvODlizszN Mo[4NlI4PDl|OUK=
HL60 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= NXjiSmlxPzJiaB?= M4TOPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDFiYYPzZZkhcW5icILld4Vv[2Vib3[gNlAmKE[EUzygTWM2OD1zND6zJO69VQ>? NY\HS5ZSOjJ7MEG4PVU>
MSTO-211H cells MV7Qdo9tcW[ncnH0bY9vKGG|c3H5 M3fYWVczKGh? NITrcodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3TWG8uOjFzSDDj[YxteyCjZoTldkA4OiCqcoOgZpkhfHK7cHHuJIJtfWViYYPzZZktKEmFNUC9NlMvOyEQvF2= MWOyN|c{PTh{OR?=
HepG2 cells M{nvcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NF73UIozPCCq NXHtTW1rS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KEOnbHzUbZRmei2EbIXlR4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPM7:TR?= MknWNlA2PDV|M{S=
KIF5 cells M4iyVmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlnpNlQhcA>? MoXJWI95cWOrdImgZYdicW6|dDDoeY1idiCNSV[1JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KEOnbHzUbZRmeiCEbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{Njd3IN88US=> M2HXN|IzPzd3NEe0

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03691493 Not yet recruiting Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Bone|Progesterone Receptor Positive|Prognostic Stage IV Breast Cancer AJCC v8 Emory University|Pfizer December 1 2018 Phase 2
NCT03554044 Not yet recruiting Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Invasive Breast Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Recurrent Breast Carcinoma University of California San Francisco|Amgen December 11 2018 Phase 1
NCT03058939 Withdrawn Breast Cancer|Breast Cancer Stage II|Breast Cancer Stage III University of Chicago November 2018 Phase 2
NCT02801786 Not yet recruiting Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3
NCT03528902 Recruiting Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension|Primary Pulmonary Hypertension|Lung Diseases|Tamoxifen|Estrogen Receptor Antagonist|Hormone Antagonists|Estrogens Vanderbilt University Medical Center October 1 2018 Phase 2
NCT03582865 Not yet recruiting Breast Cancer Assiut University September 1 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID