Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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Cited by 10 Publications

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MVzGeY5kfGmxbjDhd5NigQ>? NVjlR4F[TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFXDOVA:OC5yMTFOwG0> MlvkNVI5OjV7M{W=
MCF7 cells MVrDfZRwfG:6aXPpeJkh[XO|YYm= NFWyZZI1QCCq NWnJTINJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ5IN88US=> MmDINlI1PzJyNEW=
Ishikawa cells MlzISpVv[3Srb36gZZN{[Xl? NV\LSHk5S2:wY3XueJJifGmxbjDv[kBkd22yb4Xu[EBz\XG3aYLl[EB1dyCrbnT1Z4UhPTBiJTDv[kB1cGVibXH4bY12dSC|dHnteYxifGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCjY4Tpeol1gSCrbjDJd4hqc2G5YTDj[YxteyxiRVO1NF0xNjB|MzFOwG0> MVW4NlAyPTh5
HEK293T cells MljjSpVv[3Srb36gZZN{[Xl? MV3BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEejbESgSGJFNW[3c3XkJIh2dWGwIFXSZYxxcGFiTFLEJIV5eHKnc4Pl[EBqdiCKRVuyPVNVKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[g[ZN1emGmaX;sMYlv\HWlZXSgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZYZ1\XJiMkCgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlA{QSEQvF2= Mkj1NlM4QDZ2NUK=
MDA-MB-435 cells NUHqWVlzTnWwY4Tpc44h[XO|YYm= Ml\mTY5pcWKrdHnvckBw\iCPRFGtUWIuPDN3IHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODVizszN MVOxOFk4OTh7OR?=
MDA-MB-231 cells MULGeY5kfGmxbjDhd5NigQ>? M4fMO2lvcGmkaYTpc44hd2ZiZYP0do9o\W5icnXj[ZB1d3JibnXnZZRqfmViTVTBMW1DNTJ|MTDidoVie3RiY3HuZ4VzKGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjB6IN88US=> NFHWTo4yPDl5MUi5PS=>
T47D cells MW\GeY5kfGmxbjDhd5NigQ>? M1fi[GFvfGmnc4Tyc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIGS0O2Qh[2WubIOg[ZhxemW|c3nu[{Bme3S{b3flckBz\WOncITvdkBie3Onc4Pl[EBieyCnc4Tyc4dmdi2mZYDlcoRmdnRidILhcpNkemmydHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6xJO69VQ>? NIDCV4gyQTF|MUK0PC=>
Ishikawa cells MX\GeY5kfGmxbjDhd5NigQ>? NVPK[|ZKPzJiaB?= NGe2eHJCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQh[WytYXzpcoUheGixc4DoZZRie2ViYXP0bZZqfHliYX\0[ZIhPzJiaILzMEBKSzVyPUCuNVch|ryP NFPUU4UyQDh|NUG3Oi=>
MCF-7-2a cells M2LKNWZ2dmO2aX;uJIF{e2G7 NIH1WppCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBOS0ZvNz2yZUBk\WyuczDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDld5Rz[WSrb3yg[YZn\WO2IHL5JFUxLSxiSVO1NF0xNjVizszN Mm\QNVI1OzFyNkO=
EL4 cell NX3OfGlCWHKxbHnm[ZJifGmxbjDhd5NigQ>? NYT5OotqUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= NGHWc|MyPTd|NkOw
HeLa cells Ml64SpVv[3Srb36gZZN{[Xl? M163TGlvcGmkaYTpc44hd2ZiMUetZoV1[S2nc4TyZYRqd2xibXXkbYF1\WRibIXjbYZmemG|ZTD0doFve2O{aYD0bY9vKGmwIFjlUIEh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDhcJBp[TtiRWLFJIF{e2G7LDDJR|UxRTBwNkKyJO69VQ>? MmjnNVU3PTh6NUG=
MDA-MB-231 cells Mn;IVJJwdGmoZYLheIlwdiCjc4PhfS=> NUPGT3A2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlY3KM7:TR?= MYWyNFQ2OTN6MB?=
T47D cells MlvBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXzPW52PzJiaB?= NVvtcm95T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h\XO2cn;n[Y4u\GWyZX7k[Y51KFR2N1SgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGg{txO NXPZOFE{OTlzM{GyOFg>
yeast AH109 cells NIDIdJhHfW6ldHnvckBie3OjeR?= MUmyOEBp MmDBRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnLleIEhemWlZYD0c5IhVEKGIHX4dJJme3OnZDDpckB6\WG|dDDBTFExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIlvfGW{YXP0bY9vKHerdHigV3JEOSCjZoTldkAzPCCqcoOgZpkh[WyyaHGt[4Ft[WO2b4Pp[IF{\SCjc4PhfUwhUUN3ME2xMlY3KM7:TR?= Mnu1NlI3PDd{MUe=
GBM2 cells MX3Qdo9tcW[ncnH0bY9vKGG|c3H5 NGXndWs4OiCq NISyeGxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF0{NjVizszN MmHxNlY{PTV3M{K=
NCI-H460 cells M2ThUWZ2dmO2aX;uJIF{e2G7 MWmyOEBp MU\BcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= NEWyTJEyQTd|M{C4OS=>
GBM3 cells MlLDVJJwdGmoZYLheIlwdiCjc4PhfS=> MUO3NkBp NWXTRopDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHRm0{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBYW1RvMTDt[ZRpd2RuIFnDOVA:PC55IN88US=> MkDINlY{PTV3M{K=
DLD1 cells Ml7uR5l1d3SxeHnjbZR6KGG|c3H5 NGruSlI6PiCq NVXnfXlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEyGMTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPzhizszN M{n4b|IzPzR7M{my
ScN2a-cl3 cells M{X2SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnfkOUBl[Xm| M{HFW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJIRqfmmmaX7nJHNkVjKjLXPsN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB3IHThfZMh[nliY3HsZ4Vqdi2DTTDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:PC56OTFOwG0> M17xbVI1OTh|NUi5
K562 cells NXrZdYtUWHKxbHnm[ZJifGmxbjDhd5NigQ>? MVO3NkBp NVfVbm8{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF02NjJizszN MXiyOVQzODF5NR?=
MDA-MB-435S cells MVjDfZRwfG:6aXPpeJkh[XO|YYm= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDifUBOXFRiYYPzZZktKEmFNUC9OU42KM7:TR?= MXiyOlA4QTB7MB?=
DU145 cells M4fSUHBzd2yrZnXyZZRqd25iYYPzZZk> NXzi[mRSPDhiaB?= NEDEZXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT61JO69VQ>? NVLWbphEOjN{OEewOVc>
HepG2 cells NX7KfpFQWHKxbHnm[ZJifGmxbjDhd5NigQ>? MmfGOFghcA>? NWm3N2xsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPU[uN{DPxE1? M2\JclI{Ojh5MEW3
SKOV3 cells MkXHSpVv[3Srb36gZZN{[Xl? NYDvRZNrOjRiaB?= MXnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD14LkSg{txO NEG2eVEyQTd|M{C4OS=>
PC3 cells MnHLVJJwdGmoZYLheIlwdiCjc4PhfS=> MnzoNlQhcA>? NITMUnRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTdizszN MX6yOFg5ODJ|MB?=
NIH/3T3 cells MVjDfZRwfG:6aXPpeJkh[XO|YYm= MmHGPVYhcA>? MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{4zPiEQvF2= NG\WXo8zOjd2OUO5Ni=>
GBM1 cells NXy4WW82WHKxbHnm[ZJifGmxbjDhd5NigQ>? MXq3NkBp MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME23MlUh|ryP MX:yOlM2PTV|Mh?=
518A2 cells MV7DfZRwfG:6aXPpeJkh[XO|YYm= MoeyPVYhcA>? MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuOlIh|ryP NFLLUG8zOjd2OUO5Ni=>
A2780 cells M4foZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIXOUGY6PiCq MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuO|ch|ryP M1HWfVIzPzR7M{my
A549 cells M{nYOmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVHQdIJqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCkeTDNWHQh[XO|YYmsJGlEPTB;OD60JO69VQ>? NIDCUo4zPjB5OUC5NC=>
Lipo cells NVzUR4xsS3m2b4TvfIlkcXS7IHHzd4F6 NH;lSGg6PiCq NUTGe|FnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN MmLmNlI4PDl|OUK=
A253 cells Mny0R5l1d3SxeHnjbZR6KGG|c3H5 MmqyPVYhcA>? NFP6UYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjV|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE46OiEQvF2= M{fhOVIzPzR7M{my
HT-29 cells M1[wS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIWE0zQSClZXzsd{whUUN3ME25MlUh|ryP MonpNlM1ODNyOES=
LNCAP cells NEHlN3pRem:uaX\ldoF1cW:wIHHzd4F6 NEDWdpg1QCCq NV20dYJKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{BmgHC{ZYPzbY5oKGGwZILv[4VvKHKnY3XweI9zKGmwY4XiZZRm\CC5aYToJFAvPiCwTTDv[kBme3S{YXTpc4wh[W6mIECuO{BvVSCxZjD0[ZN1d3O2ZYLvcoUh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:OTBizszN MoT3NlE2OTN{N{W=
M21 cells MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUHhWXd6T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTJzIHPlcIx{NCCLQ{WwQVEyKM7:TR?= M3\ORVI{PDB|MEi0
850C cells NHnJ[3ZEgXSxdH;4bYNqfHliYYPzZZk> NX3CXHl7QTZiaB?= Ml;SR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxSyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGxMlA6KM7:TR?= NWLIZYpPOjJ5NEmzPVI>
HL60 cells NHvob4REgXSxdH;4bYNqfHliYYPzZZk> NVnrOmNnPzJiaB?= NXvROJdvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhX1OWMTDhd5NigSCrbjDwdoV{\W6lZTDv[kAzOCViRlLTMEBKSzVyPUG0MlMh|ryP MVuyNlkxOTh7NR?=
MSTO-211H cells MlvvVJJwdGmoZYLheIlwdiCjc4PhfS=> M2[2fVczKGh? MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2VVF:tNlEyUCClZXzsd{Bi\nSncjC3NkBpenNiYomgeJJ6eGGwIHLseYUh[XO|YYmsJGlEPTB;MkOuN{DPxE1? Mlv1NlM4OzV6Mkm=
HepG2 cells NVPMO5M6S3m2b4TvfIlkcXS7IHHzd4F6 Mn\INlQhcA>? NXO2PJd2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KEOnbHzUbZRmei2EbIXlR4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPM7:TR?= NFfXbWozODV2NUOzOC=>
KIF5 cells M3H5fmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGjZN5AzPCCq MVnUc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN M{LSTVIzPzd3NEe0

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03582865 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer Assiut University September 1 2019 --
NCT02801786 Not yet recruiting Drug: Placebo|Drug: Lidocaine|Drug: Tamoxifen Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3
NCT03707340 Recruiting Drug: Flibanserin Pill Breast Cancer|Hyposexual Desire Disorder Memorial Sloan Kettering Cancer Center September 14 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID