Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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Cited by 18 Publications

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M4nWO2Z2dmO2aX;uJIF{e2G7 M1K2OWVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiTVPGMVch[nKnYYP0JJR2dW:{IHPlcIx{KHW|aX7nJG1ETi15IHHzd4F6NCCHQ{WwQVAvODFizszN NHWxZ2gyOjh{NUmzOS=>
MCF7 cells NFrIO4VEgXSxdH;4bYNqfHliYYPzZZk> MVW0PEBp MoLlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFI4KM7:TR?= MWmyNlQ4OjB2NR?=
Ishikawa cells M{K0d2Z2dmO2aX;uJIF{e2G7 NFXwZpBEd26lZX70doF1cW:wIH;mJINwdXCxdX7kJJJmeXWrcnXkJJRwKGmwZIXj[UA2OCBnIH;mJJRp\SCvYYjpcZVuKHO2aX31cIF1cW:wIH;mJIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGGldHn2bZR6KGmwIFnzbIls[XejIHPlcIx{NCCHQ{WwQVAvODN|IN88US=> M2\jVVgzODF3OEe=
HEK293T cells M3\LcmZ2dmO2aX;uJIF{e2G7 M4j5eGFvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> MnrWNlM4QDZ2NUK=
MDA-MB-435 cells MXfGeY5kfGmxbjDhd5NigQ>? Mn;0TY5pcWKrdHnvckBw\iCPRFGtUWIuPDN3IHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODVizszN NIntXYUyPDl5MUi5PS=>
MDA-MB-231 cells NEfhNHNHfW6ldHnvckBie3OjeR?= NEPPWolKdmirYnn0bY9vKG:oIHXzeJJw\2WwIILlZ4VxfG:{IH7l[4F1cX[nIF3ERU1OSi1{M{GgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yODFOwG0> NIPHfWIyPDl5MUi5PS=>
T47D cells MVHGeY5kfGmxbjDhd5NigQ>? M1H5N2FvfGmnc4Tyc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIGS0O2Qh[2WubIOg[ZhxemW|c3nu[{Bme3S{b3flckBz\WOncITvdkBie3Onc4Pl[EBieyCnc4Tyc4dmdi2mZYDlcoRmdnRidILhcpNkemmydHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6xJO69VQ>? MXyxPVE{OTJ2OB?=
Ishikawa cells NXS1ZnZzTnWwY4Tpc44h[XO|YYm= NGDnOVg4OiCq MWfBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCLc3jpb4F4[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKxZ3XuMYlv\HWlZXSgZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwMUeg{txO MVGxPFg{PTF5Nh?=
MCF-7-2a cells M37icWZ2dmO2aX;uJIF{e2G7 NYXkU|JtSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hVUOILUetNoEh[2WubIOgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3Wg[ZN1emGmaX;sJIVn\mWldDDifUA2OCVuIFnDOVA:OC53IN88US=> MX6xNlQ{OTB4Mx?=
EL4 cell NEjtbVFRem:uaX\ldoF1cW:wIHHzd4F6 M4nhdmlvcGmkaYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHnueI8hTUx2IHPlcIwheHKxbHnm[ZJifGmxbjygbYM2OD1yLkWzOUDPxE1? MYqxOVc{PjNy
HeLa cells NFTjdYxHfW6ldHnvckBie3OjeR?= MX7Jcohq[mm2aX;uJI9nKDF5LXLleIEu\XO2cnHkbY9tKG2nZHnheIVlKGy3Y3nm[ZJie2VidILhcpNkemmydHnvckBqdiCKZVzhJINmdGy|IHX4dJJme3OrbnegbJVu[W5iZYP0do9o\W5icnXj[ZB1d3JiYXzwbIE8KEWURTDhd5NigSxiSVO1NF0xNjZ{MjFOwG0> NF\nXHAyPTZ3OEi1NS=>
MDA-MB-231 cells NYC2V|VUWHKxbHnm[ZJifGmxbjDhd5NigQ>? Ml7CRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[2JO69VQ>? M3\idlIxPDVzM{iw
T47D cells M2myXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1uwb|czKGh? M2OxZWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJIV{fHKxZ3XuMYRmeGWwZHXueEBVPDeGIHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1zIN88US=> NWDJUI9MOTlzM{GyOFg>
yeast AH109 cells MlGzSpVv[3Srb36gZZN{[Xl? MXGyOEBp MlXhRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnLleIEhemWlZYD0c5IhVEKGIHX4dJJme3OnZDDpckB6\WG|dDDBTFExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIlvfGW{YXP0bY9vKHerdHigV3JEOSCjZoTldkAzPCCqcoOgZpkh[WyyaHGt[4Ft[WO2b4Pp[IF{\SCjc4PhfUwhUUN3ME2xMlY3KM7:TR?= NXjOfGZKOjJ4NEeyNVc>
GBM2 cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 NXnJXHV[PzJiaB?= MoDmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJQl2yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDXV3QuOSCvZYToc4QtKEmFNUC9N{42KM7:TR?= MoqxNlY{PTV3M{K=
NCI-H460 cells NV\PfJFGTnWwY4Tpc44h[XO|YYm= MYGyOEBp MVLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= MmezNVk4OzNyOEW=
GBM3 cells MYTQdo9tcW[ncnH0bY9vKGG|c3H5 MmDnO|IhcA>? MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME20Mlch|ryP M1juU|I3OzV3NUOy
DLD1 cells NFT4PXNEgXSxdH;4bYNqfHliYYPzZZk> NIXFWWg6PiCq NXO0XYI6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEyGMTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPzhizszN MWCyNlc1QTN7Mh?=
ScN2a-cl3 cells MnzDR5l1d3SxeHnjbZR6KGG|c3H5 NUTZXpZXPSCmYYnz MlPLR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3Wg[Il3cWSrbnegV4NPOmFvY3yzJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDViZHH5d{BjgSClYXzj[YlvNUGPIIP0ZYlvcW6pLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NF01Njh7IN88US=> NWfCWYU1OjRzOEO1PFk>
K562 cells NFG3Z4lRem:uaX\ldoF1cW:wIHHzd4F6 NIraWGU4OiCq NWHUZYRxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF02NjJizszN M2\sZlI2PDJyMUe1
MDA-MB-435S cells Mn;QR5l1d3SxeHnjbZR6KGG|c3H5 M{SyZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|VUKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDhd5NigSxiSVO1NF02NjVizszN MlLUNlYxPzlyOUC=
DU145 cells NUi1d|JMWHKxbHnm[ZJifGmxbjDhd5NigQ>? M4\5T|Q5KGh? NYn3RolWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUWuOUDPxE1? MVyyN|I5PzB3Nx?=
HepG2 cells M1;hRnBzd2yrZnXyZZRqd25iYYPzZZk> M4\lXlQ5KGh? M4rCV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14LkOg{txO MV[yN|I5PzB3Nx?=
SKOV3 cells NXPKZnM{TnWwY4Tpc44h[XO|YYm= MVyyOEBp MW\BcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD14LkSg{txO MlzwNVk4OzNyOEW=
PC3 cells M1e1N3Bzd2yrZnXyZZRqd25iYYPzZZk> M1PjfVI1KGh? M{K5S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PyEQvF2= NYXEVnB6OjR6OECyN|A>
NIH/3T3 cells NInmXHNEgXSxdH;4bYNqfHliYYPzZZk> MXW5OkBp MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{4zPiEQvF2= NEDBdVMzOjd2OUO5Ni=>
GBM1 cells NVf4dmpNWHKxbHnm[ZJifGmxbjDhd5NigQ>? NXfUPY9SPzJiaB?= NYPhNJNDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHRm0yKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBYW1RvMTDt[ZRpd2RuIFnDOVA:Py53IN88US=> M3\4SFI3OzV3NUOy
518A2 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= NVfycXlUQTZiaB?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuOlIh|ryP M3X2VFIzPzR7M{my
A2780 cells NEnWWpVEgXSxdH;4bYNqfHliYYPzZZk> NEW1dXE6PiCq MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuO|ch|ryP NFjuTGozOjd2OUO5Ni=>
A549 cells NGDoSopEgXSxdH;4bYNqfHliYYPzZZk> MoflR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBjgSCPVGSgZZN{[XluIFnDOVA:QC52IN88US=> NIfNOZAzPjB5OUC5NC=>
Lipo cells NXzlcVB{S3m2b4TvfIlkcXS7IHHzd4F6 MXO5OkBp MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMbZBwKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;OD62OEDPxE1? NE\iNJczOjd2OUO5Ni=>
A253 cells NITxdWlEgXSxdH;4bYNqfHliYYPzZZk> MUW5OkBp NHi2V5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjV|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE46OiEQvF2= NWrnOo5JOjJ5NEmzPVI>
HT-29 cells MmHTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjBTmZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJXC1{OTDj[YxteyxiSVO1NF06NjVizszN NW\wVYlROjN2MEOwPFQ>
LNCAP cells NVr6RW13WHKxbHnm[ZJifGmxbjDhd5NigQ>? M3PPW|Q5KGh? MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHX4dJJme3OrbnegZY5lem:pZX6gdoVk\XC2b4KgbY5kfWKjdHXkJJdqfGhiMD62JI5OKG:oIHXzeJJi\GmxbDDhcoQhOC55IH7NJI9nKHSnc4Tvd5Rmem:wZTDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2xNEDPxE1? MYOyNVUyOzJ5NR?=
M21 cells MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULPW|dVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTJzIHPlcIx{NCCLQ{WwQVEyKM7:TR?= M1frdlI{PDB|MEi0
850C cells MonoR5l1d3SxeHnjbZR6KGG|c3H5 NXjPUIJSQTZiaB?= MmfmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxSyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGxMlA6KM7:TR?= NU\SZm81OjJ5NEmzPVI>
HL60 cells MU\DfZRwfG:6aXPpeJkh[XO|YYm= NXjyXGpIPzJiaB?= M3\Ne2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDFiYYPzZZkhcW5icILld4Vv[2Vib3[gNlAmKE[EUzygTWM2OD1zND6zJO69VQ>? M2noclIzQTBzOEm1
MSTO-211H cells MYrQdo9tcW[ncnH0bY9vKGG|c3H5 MWG3NkBp NYPlW2MxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNV3RQNTJzMVigZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDhckBjdHWnIHHzd4F6NCCLQ{WwQVI{NjNizszN NEnQbnAzOzd|NUiyPS=>
HepG2 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= NUPwOXR{OjRiaB?= MmHnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNmdGyWaYTldk1DdHWnQ3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOO69VQ>? MV[yNFU1PTN|NB?=
KIF5 cells NGXhUpJEgXSxdH;4bYNqfHliYYPzZZk> NYL2SVBlOjRiaB?= MVrUc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN NGLIV48zOjd5NUS3OC=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03582865 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer Assiut University September 1 2019 --
NCT02801786 Not yet recruiting Drug: Placebo|Drug: Lidocaine|Drug: Tamoxifen Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3
NCT03707340 Recruiting Drug: Flibanserin Pill Breast Cancer|Hyposexual Desire Disorder Memorial Sloan Kettering Cancer Center September 14 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID