Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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Cited by 4 Publications

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NHjlbZdHfW6ldHnvckBie3OjeR?= NIi3R5lG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> NELrXYkyOjh{NUmzOS=>
MCF7 cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= NUnieI5xPDhiaB?= MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wNlch|ryP NFzrdoszOjR5MkC0OS=>
Ishikawa cells MmK3SpVv[3Srb36gZZN{[Xl? MXfDc45k\W62cnH0bY9vKG:oIHPvcZBwfW6mIILldZVqemWmIITvJIlv\HWlZTC1NEAmKG:oIITo[UBu[XirbYXtJJN1cW23bHH0bY9vKG:oIHHsb4FtcW6nIIDoc5NxcGG2YYPlJIFkfGm4aYT5JIlvKEm|aHnrZZdiKGOnbHzzMEBGSzVyPUCuNFM{KM7:TR?= NWTIT494QDJyMUW4Oy=>
HEK293T cells NUPGOlN[TnWwY4Tpc44h[XO|YYm= MknNRY51[WexbnnzeEBi[3Srdnn0fUBifCCJYXy0JGRDTC2odYPl[EBpfW2jbjDFVoFteGijIFzCSEBmgHC{ZYPz[YQhcW5iSFXLNlk{XCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJJRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIFnfGW{IEKwJIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4xOzlizszN MWmyN|c5PjR3Mh?=
MDA-MB-435 cells MYfGeY5kfGmxbjDhd5NigQ>? NFr2SZpKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> MYGxOFk4OTh7OR?=
MDA-MB-231 cells M2[0cWZ2dmO2aX;uJIF{e2G7 NVvmdXhVUW6qaXLpeIlwdiCxZjDld5Rzd2enbjDy[YNmeHSxcjDu[YdifGm4ZTDNSGEuVUJvMkOxJIJz\WG|dDDjZY5k\XJiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEig{txO NXriZmRIOTR7N{G4PVk>
T47D cells MnjySpVv[3Srb36gZZN{[Xl? NVLJemM{SW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gWFQ4TCClZXzsd{BmgHC{ZYPzbY5oKGW|dILv[4VvKHKnY3XweI9zKGG|c3Xzd4VlKGG|IHXzeJJw\2WwLXTldIVv\GWwdDD0doFve2O{aYD0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlEh|ryP MnOwNVkyOzF{NEi=
Ishikawa cells MXjGeY5kfGmxbjDhd5NigQ>? MnfQO|IhcA>? NHHG[YZCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQh[WytYXzpcoUheGixc4DoZZRie2ViYXP0bZZqfHliYX\0[ZIhPzJiaILzMEBKSzVyPUCuNVch|ryP NHjNeWgyQDh|NUG3Oi=>
MCF-7-2a cells M4noN2Z2dmO2aX;uJIF{e2G7 Mm\kRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gUWNHNTdvMnGgZ4VtdHNiYYOgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2ViZYP0doFlcW:uIHXm[oVkfCCkeTC1NEUtKEmFNUC9NE42KM7:TR?= MmXKNVI1OzFyNkO=
EL4 cell NVHwOopEWHKxbHnm[ZJifGmxbjDhd5NigQ>? NY\2SGFrUW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCHTESgZ4VtdCCycn;sbYZmemG2aX;uMEBq[zVyPUCuOVM2KM7:TR?= NGjSSVIyPTd|NkOw
HeLa cells MYXGeY5kfGmxbjDhd5NigQ>? NInuc4dKdmirYnn0bY9vKG:oIEG3MYJmfGFvZYP0doFlcW:uIH3l[IlifGWmIHz1Z4ln\XKjc3WgeJJidnOlcnnweIlwdiCrbjDI[WxiKGOnbHzzJIV5eHKnc4PpcochcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4KgZYxxcGF9IFXSSUBie3OjeTygTWM2OD1yLk[yNkDPxE1? NHzxb|cyPTZ3OEi1NS=>
MDA-MB-231 cells MkThVJJwdGmoZYLheIlwdiCjc4PhfS=> M2XicmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD62OkDPxE1? M1W5[lIxPDVzM{iw
T47D cells NWD0Oo8zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2\mUFczKGh? MXXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDld5Rzd2enbj3k[ZBmdmSnboSgWFQ4TCClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OSEQvF2= MXOxPVE{OTJ2OB?=
yeast AH109 cells NU\3RZV1TnWwY4Tpc44h[XO|YYm= NYD0coJxOjRiaB?= M4H1S2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLi[ZRiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBqdnSncnHjeIlwdiC5aYToJHNTSzFiYX\0[ZIhOjRiaILzJIJ6KGGucHjhMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9NU43PiEQvF2= MXiyNlY1PzJzNx?=
GBM2 cells MlPuVJJwdGmoZYLheIlwdiCjc4PhfS=> NHrVe2U4OiCq NXnuXFNbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHRm0zKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBYW1RvMTDt[ZRpd2RuIFnDOVA:Oy53IN88US=> NFnzRZkzPjN3NUWzNi=>
NCI-H460 cells MXHGeY5kfGmxbjDhd5NigQ>? NWDzZ2hMOjRiaB?= M3nlUmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVQvPDhizszN MX2xPVc{OzB6NR?=
GBM3 cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 NUTybIh5PzJiaB?= NGTwRWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVMh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF01NjdizszN MmjLNlY{PTV3M{K=
DLD1 cells Ml\hR5l1d3SxeHnjbZR6KGG|c3H5 MXq5OkBp NGrxTXpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFVERzIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE44QCEQvF2= MkmxNlI4PDl|OUK=
ScN2a-cl3 cells NUWzd|J2S3m2b4TvfIlkcXS7IHHzd4F6 MX21JIRigXN? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDkbZZq\GmwZzDTZ24z[S2lbEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPSCmYYnzJIJ6KGOjbHPlbY4uSU1ic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVQvQDlizszN NUnNeXNtOjRzOEO1PFk>
K562 cells NGS4SVVRem:uaX\ldoF1cW:wIHHzd4F6 M3ziO|czKGh? MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NWj0N5I3OjV2MkCxO|U>
MDA-MB-435S cells MknGR5l1d3SxeHnjbZR6KGG|c3H5 MnXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZpkhVVSWIHHzd4F6NCCLQ{WwQVUvPSEQvF2= NYrDZXc6OjZyN{mwPVA>
DU145 cells NGPFWpNRem:uaX\ldoF1cW:wIHHzd4F6 NXvJPIl[PDhiaB?= MmKzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNTFOwG0> NU\5NotUOjN{OEewOVc>
HepG2 cells NEKzWoNRem:uaX\ldoF1cW:wIHHzd4F6 M4PNfVQ5KGh? NXnD[40zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPU[uN{DPxE1? MX6yN|I5PzB3Nx?=
SKOV3 cells M{jJOWZ2dmO2aX;uJIF{e2G7 NUjnXpdWOjRiaB?= MoPYRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLU3Y{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;Nj60JO69VQ>? M1;VRVE6PzN|MEi1
PC3 cells Mn3XVJJwdGmoZYLheIlwdiCjc4PhfS=> MmHuNlQhcA>? MkOyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF04KM7:TR?= M{jU[FI1QDhyMkOw
NIH/3T3 cells NIDCenpEgXSxdH;4bYNqfHliYYPzZZk> M3m1UFk3KGh? M1XtR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjJ4IN88US=> MnTVNlI4PDl|OUK=
GBM1 cells NXKxeHpOWHKxbHnm[ZJifGmxbjDhd5NigQ>? MV23NkBp NHXMT5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF04NjVizszN Mk\DNlY{PTV3M{K=
518A2 cells NF;wW2dEgXSxdH;4bYNqfHliYYPzZZk> NGXTblA6PiCq NGPCWGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA2OTiDMjDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvPjJizszN NYHocGJMOjJ5NEmzPVI>
A2780 cells NWXQcFdkS3m2b4TvfIlkcXS7IHHzd4F6 M4W1W|k3KGh? MmnaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23Mlc4KM7:TR?= M322Z|IzPzR7M{my
A549 cells MXzDfZRwfG:6aXPpeJkh[XO|YYm= M4Hye2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7LDDJR|UxRThwNDFOwG0> MX6yOlA4QTB7MB?=
Lipo cells NXH6[HZpS3m2b4TvfIlkcXS7IHHzd4F6 MUm5OkBp NUTQ[G5oS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN NVL5VZd2OjJ5NEmzPVI>
A253 cells NX[1e4E1S3m2b4TvfIlkcXS7IHHzd4F6 M4C3dlk3KGh? MknyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI2OyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUiuPVIh|ryP M1rkUVIzPzR7M{my
HT-29 cells MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1f4ZWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIx{NCCLQ{WwQVkvPSEQvF2= MXWyN|QxOzB6NB?=
LNCAP cells Ml;6VJJwdGmoZYLheIlwdiCjc4PhfS=> M2LLUVQ5KGh? MkPjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDlfJBz\XO|aX7nJIFv\HKxZ3XuJJJm[2WydH;yJIlv[3WkYYTl[EB4cXSqIECuOkBvVSCxZjDld5Rz[WSrb3ygZY5lKDBwNzDuUUBw\iC2ZYP0c5N1\XKxbnWgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUC9NVAh|ryP NX3wfGFDOjF3MUOyO|U>
M21 cells M{Sxfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkLQS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVIyKGOnbHzzMEBKSzVyPUGxJO69VQ>? MX[yN|QxOzB6NB?=
850C cells NU\QUWJNS3m2b4TvfIlkcXS7IHHzd4F6 NIXxdpk6PiCq NWT6Om93S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDVyQzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEyNjB7IN88US=> MoPTNlI4PDl|OUK=
HL60 cells MojyR5l1d3SxeHnjbZR6KGG|c3H5 MkP4O|IhcA>? NGHNXVJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RzIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFIxLSCIQmOsJGlEPTB;MUSuN{DPxE1? M{f2NFIzQTBzOEm1
MSTO-211H cells MkPvVJJwdGmoZYLheIlwdiCjc4PhfS=> MXu3NkBp M4XCU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTWPUU{0zOTGKIHPlcIx{KGGodHXyJFczKGi{czDifUB1enmyYX6gZox2\SCjc4PhfUwhUUN3ME2yN{4{KM7:TR?= M3OxPVI{PzN3OEK5
HepG2 cells NIfkU4ZEgXSxdH;4bYNqfHliYYPzZZk> NHG5[5UzPCCq MoDpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNmdGyWaYTldk1DdHWnQ3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOO69VQ>? MXyyNFU1PTN|NB?=
KIF5 cells NFHqZ2tEgXSxdH;4bYNqfHliYYPzZZk> NHzmNYQzPCCq Mle5WI95cWOrdImgZYdicW6|dDDoeY1idiCNSV[1JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KEOnbHzUbZRmeiCEbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{Njd3IN88US=> NXPHS5NvOjJ5N{W0O|Q>

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03691493 Not yet recruiting Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Bone|Progesterone Receptor Positive|Prognostic Stage IV Breast Cancer AJCC v8 Emory University|Pfizer December 1 2018 Phase 2
NCT03554044 Not yet recruiting Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Invasive Breast Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Recurrent Breast Carcinoma University of California San Francisco|Amgen December 11 2018 Phase 1
NCT03058939 Withdrawn Breast Cancer|Breast Cancer Stage II|Breast Cancer Stage III University of Chicago November 2018 Phase 2
NCT02801786 Not yet recruiting Pain|Discomfort Universidade Federal de Goias November 2018 Phase 2|Phase 3
NCT03528902 Recruiting Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension|Primary Pulmonary Hypertension|Lung Diseases|Tamoxifen|Estrogen Receptor Antagonist|Hormone Antagonists|Estrogens Vanderbilt University Medical Center October 1 2018 Phase 2
NCT03582865 Not yet recruiting Breast Cancer Assiut University September 1 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID