Tamoxifen

For research use only.

Catalog No.S1238 Synonyms: ICI 46474

33 publications

Tamoxifen Chemical Structure

CAS No. 10540-29-1

Tamoxifen (ICI 46474) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.

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Selleck's Tamoxifen has been cited by 33 publications

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Biological Activity

Description Tamoxifen (ICI 46474) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MXnGeY5kfGmxbjDhd5NigQ>? NEDrelBG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> NVLNVlB[OTJ6MkW5N|U>
MCF7 cells NFXLVo5EgXSxdH;4bYNqfHliYYPzZZk> NUPJeIJQPDhiaB?= MlrnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFI4KM7:TR?= M3zXfVIzPDd{MES1
Ishikawa cells M1jpUWZ2dmO2aX;uJIF{e2G7 M321e2NwdmOnboTyZZRqd25ib3[gZ49ueG:3bnSgdoVyfWm{ZXSgeI8hcW6mdXPlJFUxKCVib3[geIhmKG2jeHnteY0he3SrbYXsZZRqd25ib3[gZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkhcW5iSYPobYtif2FiY3XscJMtKEWFNUC9NE4xOzNizszN NHf2UJE5OjBzNUi3
HEK293T cells Mn\HSpVv[3Srb36gZZN{[Xl? NXW4NGsySW62YXfvcol{fCCjY4Tpeol1gSCjdDDHZYw1KESERD3meZNm\CCqdX3hckBGWmGucHjhJGxDTCCneIDy[ZN{\WRiaX6gTGVMOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILh[IlwdC2rbnT1Z4VlKHS{YX7zZ5JqeHSrb37hcEBi[3SrdnH0bY9vKGGodHXyJFIxKGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5yM{mg{txO MX6yN|c5PjR3Mh?=
MDA-MB-435 cells NFqzNXJHfW6ldHnvckBie3OjeR?= NEK0UYpKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> Mo\WNVQ6PzF6OUm=
MDA-MB-231 cells MY\GeY5kfGmxbjDhd5NigQ>? NUjlXGZ[UW6qaXLpeIlwdiCxZjDld5Rzd2enbjDy[YNmeHSxcjDu[YdifGm4ZTDNSGEuVUJvMkOxJIJz\WG|dDDjZY5k\XJiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEig{txO NVO4XHVtOTR7N{G4PVk>
T47D cells NX64fGZ7TnWwY4Tpc44h[XO|YYm= MUXBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHX4dJJme3Orbneg[ZN1em:pZX6gdoVk\XC2b4KgZZN{\XO|ZXSgZZMh\XO2cn;n[Y4u\GWyZX7k[Y51KHS{YX7zZ5JqeHSrb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMTFOwG0> Mo\JNVkyOzF{NEi=
Ishikawa cells MYrGeY5kfGmxbjDhd5NigQ>? M1L0TlczKGh? NIiwS4xCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQh[WytYXzpcoUheGixc4DoZZRie2ViYXP0bZZqfHliYX\0[ZIhPzJiaILzMEBKSzVyPUCuNVch|ryP NED5eGgyQDh|NUG3Oi=>
MCF-7-2a cells MUTGeY5kfGmxbjDhd5NigQ>? NEHSZo1CdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBOS0ZvNz2yZUBk\WyuczDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDld5Rz[WSrb3yg[YZn\WO2IHL5JFUxLSxiSVO1NF0xNjVizszN MYCxNlQ{OTB4Mx?=
EL4 cell M33ROHBzd2yrZnXyZZRqd25iYYPzZZk> MojXTY5pcWKrdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlv[2:{cH;yZZRqd25iaX70c{BGVDRiY3XscEBxem:uaX\ldoF1cW:wLDDpZ|UxRTBwNUO1JO69VQ>? NWn1NooyOTV5M{[zNC=>
HeLa cells MWDGeY5kfGmxbjDhd5NigQ>? NUHXdGFlUW6qaXLpeIlwdiCxZjCxO{1j\XSjLXXzeJJi\GmxbDDt[YRq[XSnZDDseYNq\mW{YYPlJJRz[W6|Y4LpdJRqd25iaX6gTIVN[SClZXzsd{BmgHC{ZYPzbY5oKGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijOzDFVmUh[XO|YYmsJGlEPTB;MD62NlIh|ryP NF\meGMyPTZ3OEi1NS=>
MDA-MB-231 cells M3rBTHBzd2yrZnXyZZRqd25iYYPzZZk> M{fuVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD62OkDPxE1? NVLCbYRWOjB2NUGzPFA>
T47D cells NVr2XXN2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHv4SYw4OiCq Mm\YS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6g[ZN1em:pZX6t[IVx\W6mZX70JHQ1P0RiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxRTFizszN NXW2W4x3OTlzM{GyOFg>
yeast AH109 cells NVrCVod{TnWwY4Tpc44h[XO|YYm= NXXYW2kxOjRiaB?= MXPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYnX0ZUBz\WOncITvdkBNSkRiZYjwdoV{e2WmIHnuJJlm[XO2IFHINVA6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gbY51\XKjY4Tpc44hf2m2aDDTVmMyKGGodHXyJFI1KGi{czDifUBidHCqYT3nZYxi[3Sxc3nkZZNmKGG|c3H5MEBKSzVyPUGuOlYh|ryP M2f6eFIzPjR5MkG3
GBM2 cells M3v6NHBzd2yrZnXyZZRqd25iYYPzZZk> MX[3NkBp MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME2zMlUh|ryP MX:yOlM2PTV|Mh?=
NCI-H460 cells M1\oT2Z2dmO2aX;uJIF{e2G7 NHrifG8zPCCq MYjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= MnT1NVk4OzNyOEW=
GBM3 cells NUTX[|BRWHKxbHnm[ZJifGmxbjDhd5NigQ>? NFXhR3k4OiCq M3PWb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVQvPyEQvF2= MkXONlY{PTV3M{K=
DLD1 cells NUL2boFTS3m2b4TvfIlkcXS7IHHzd4F6 NXP1eGVZQTZiaB?= MoOxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSGxFOSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUSuO|gh|ryP MnXXNlI4PDl|OUK=
ScN2a-cl3 cells M1TETGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX21JIRigXN? MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDkbZZq\GmwZzDTZ24z[S2lbEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPSCmYYnzJIJ6KGOjbHPlbY4uSU1ic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVQvQDlizszN M3PuTFI1OTh|NUi5
K562 cells M4i5W3Bzd2yrZnXyZZRqd25iYYPzZZk> NIq2VIo4OiCq MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NWDhZYhWOjV2MkCxO|U>
MDA-MB-435S cells MnHYR5l1d3SxeHnjbZR6KGG|c3H5 MoLRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZpkhVVSWIHHzd4F6NCCLQ{WwQVUvPSEQvF2= NGDtVHQzPjB5OUC5NC=>
DU145 cells NG\GelZRem:uaX\ldoF1cW:wIHHzd4F6 MYC0PEBp MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS53IN88US=> NULaVmxKOjN{OEewOVc>
HepG2 cells MlfKVJJwdGmoZYLheIlwdiCjc4PhfS=> MmrLOFghcA>? MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi5|IN88US=> Mmf3NlMzQDdyNUe=
SKOV3 cells M4qyUmZ2dmO2aX;uJIF{e2G7 NYO5c3h2OjRiaB?= MojzRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLU3Y{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;Nj60JO69VQ>? M3z3elE6PzN|MEi1
PC3 cells NIPGSWJRem:uaX\ldoF1cW:wIHHzd4F6 NIjP[3AzPCCq M3i2WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PyEQvF2= NXu0bJFjOjR6OECyN|A>
NIH/3T3 cells NG[0PGxEgXSxdH;4bYNqfHliYYPzZZk> Mn;3PVYhcA>? MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{4zPiEQvF2= NHjGTmQzOjd2OUO5Ni=>
GBM1 cells NGDZXW5Rem:uaX\ldoF1cW:wIHHzd4F6 NEnaXJA4OiCq M2PjXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVcvPSEQvF2= Mnr1NlY{PTV3M{K=
518A2 cells M2\rSGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4[4UVk3KGh? NYGzRZBWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjZ{IN88US=> MkTBNlI4PDl|OUK=
A2780 cells MULDfZRwfG:6aXPpeJkh[XO|YYm= M1;pR|k3KGh? NF33cFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjd6MDDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvPzdizszN MmnFNlI4PDl|OUK=
A549 cells NYXCb4lTS3m2b4TvfIlkcXS7IHHzd4F6 Mn\UR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBjgSCPVGSgZZN{[XluIFnDOVA:QC52IN88US=> NV3ye|BbOjZyN{mwPVA>
Lipo cells NYO3TXVyS3m2b4TvfIlkcXS7IHHzd4F6 M36zSVk3KGh? NXeyZ3lNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN NYH5ZlY6OjJ5NEmzPVI>
A253 cells NELvW|REgXSxdH;4bYNqfHliYYPzZZk> MUm5OkBp MmnuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI2OyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUiuPVIh|ryP NXrEW2x3OjJ5NEmzPVI>
HT-29 cells Ml22S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2i2cmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIx{NCCLQ{WwQVkvPSEQvF2= MmO1NlM1ODNyOES=
LNCAP cells NXX3fpM5WHKxbHnm[ZJifGmxbjDhd5NigQ>? NI\N[pA1QCCq MlzsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDlfJBz\XO|aX7nJIFv\HKxZ3XuJJJm[2WydH;yJIlv[3WkYYTl[EB4cXSqIECuOkBvVSCxZjDld5Rz[WSrb3ygZY5lKDBwNzDuUUBw\iC2ZYP0c5N1\XKxbnWgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUC9NVAh|ryP NXXZeXB6OjF3MUOyO|U>
M21 cells NXPsfoY{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\0S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVIyKGOnbHzzMEBKSzVyPUGxJO69VQ>? NV;TblA5OjN2MEOwPFQ>
850C cells NXrQVGo{S3m2b4TvfIlkcXS7IHHzd4F6 Mlf1PVYhcA>? MoTER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxSyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGxMlA6KM7:TR?= MXeyNlc1QTN7Mh?=
HL60 cells NFPBR2dEgXSxdH;4bYNqfHliYYPzZZk> NUfzOZBPPzJiaB?= NHWxOYREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBYW1RzIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFIxLSCIQmOsJGlEPTB;MUSuN{DPxE1? Mlr0NlI6ODF6OUW=
MSTO-211H cells MlrMVJJwdGmoZYLheIlwdiCjc4PhfS=> M1LVbFczKGh? NWrY[np{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNV3RQNTJzMVigZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDhckBjdHWnIHHzd4F6NCCLQ{WwQVI{NjNizszN MY[yN|c{PTh{OR?=
HepG2 cells NYW4NINmS3m2b4TvfIlkcXS7IHHzd4F6 M3H6ZlI1KGh? NIPvcHhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhS2WubGTpeIVzNUKudXXD[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{41|ryP MXqyNFU1PTN|NB?=
KIF5 cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= NHT6VZozPCCq MV3Uc5hq[2m2eTDh[4FqdnO2IHj1cYFvKEuLRkWgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhS2WubGTpeIVzKEKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPzVizszN MlHFNlI4PzV2N{S=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
In vivo

Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10-8 mol/L and 10-6 mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

- Collapse
  • Animal Models: Pdx1PB-CreERTm mice
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Water Insoluble
Ethanol '74 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474
Smiles CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

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Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04433494 Not yet recruiting Drug: TY-302: capsule 25mg/50mg ; Tamoxifen: tablet10mg Breast Cancer|Solid Tumor TYK Medicines Inc October 2020 Phase 1
NCT04174352 Recruiting Drug: Tamoxifen|Diagnostic Test: FES PET/CT ERα+ Breast Cancer|ESR1 Gene Mutation University of Wisconsin Madison October 20 2020 Early Phase 1
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester February 1 2020 Phase 1
NCT04312347 Recruiting Drug: Tamoxifen dose adjustment ER+ Breast Cancer Nalagenetics Pte Ltd September 6 2019 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID