For research use only. Not for use in humans.
Catalog No.S1896 Synonyms: nci-c04831, nsc32065
Molecular Weight(MW): 76.05
Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Selleck's Hydroxyurea has been cited by 10 publications
2 Customer Reviews
Lethally irradiated C57BL/6 recipient mice were injected with a 1:1 mixture of GFP+JAK2(V671F) and wild-type bone marrow cells. Five weeks later, mice were treated with vehicle (C), hydroxyurea (H; 30 mg/kg twice daily IP), ruxolitinib (R; 30 mg/kg twice daily oral gavage), BMN673 (B; 0.33 mg/kg IV), H+R, H+B, R+B, and H+R+B for 3 weeks. Percentage of GFP+JAK2(V617F) was measured in (panel B) bone marrow cells, (panel C) splenocytes, and (panel D) peripheral blood leukocytes; (panel E) number of GFP+JAK2(V617F) Lin−Sca1+c-Kit+ (LSK) cells per 106 bone marrow cells was calculated, too. *P < .05, **P < .05, and ***P < .05 when compared with control, single treatment, and double treatment, respectively, from 6 to 7 mice using the Student t test.
Blood, 2017, 130(26):2848-2859. Hydroxyurea purchased from Selleck.
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|Description||Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.|
hydroxyurea can inhibit HIV-1 replication. In vitro experiments have shown that the 90% inhibitory concentration (IC90) of hydroxyurea for laboratory strains of HIV-1 in activated PBMC is 0.4 mM. Hydroxyurea was also found to be synergistic with the nucleoside reverse transcriptase inhibitor didanosine and to inhibit HIV-1 replication in activated PBMC; this inhibition may be due to a reduction in deoxynucleoside triphosphate pool sizes. Hydroxyurea has been shown to sensitize didanosine-resistant mutants.hydroxyurea has demonstrated activity in the treatment of sickle cell anemia by increasing the production of fetal hemoglobin, which reduces hemolysis in patients with this disease. Hydroxyurea exerts its cytostatic effect through inhibition of ribonucleotide reductase—the rate-limiting enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. As a result, cellular division is arrested in the S phase.
|In vitro||DMSO||15 mg/mL (197.23 mM)|
|Water||15 mg/mL (197.23 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04093986||Recruiting||Other: Chart Review|Other: Survey||Sickle Cell Disease|Sickle Cell Anemia||Children''s Hospital Medical Center Cincinnati|University of Connecticut|University of Colorado Denver|Guy''s and St. Thomas'' Hospital|Duke University|Children''s Hospital of Philadelphia||July 22 2019||--|
|NCT03789591||Recruiting||Drug: Hydroxyurea||Sickle Cell Disease|Sickle Cell Anemia||Children''s Hospital Medical Center Cincinnati|Doris Duke Charitable Foundation||January 17 2019||Phase 3|
|NCT03763656||Recruiting||Drug: Hydroxy Urea||Sickle Cell Disease|Sickle-Cell; Hemoglobin Disease Thalassemia|Sickle Cell-beta-thalassemia|Sickle Cell Hemoglobin C||Nova Laboratories Limited||November 20 2018||Phase 2|
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