Home Apoptosis Apoptosis related inhibitor Bleomycin hydrochloride

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Bleomycin hydrochloride Apoptosis related inhibitor

Cat.No.E4789

Bleomycin hydrochloride is a natural antibiotic, an inhibitor of DNA synthesis. It binds to nuclear DNA, targeting and killing dividing cells in G2 and M phases. It exhibits anticancer activity, showing efficacy against squamous cell carcinoma (SCC) with an IC50 of 4.0 nM in the UT-SCC-19A cell line.
Bleomycin hydrochloride Apoptosis related inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 1452.01

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Chemical Information, Storage & Stability

Molecular Weight 1452.01 Formula Storage (From the date of receipt)
CAS No. 67763-87-5 -- Storage of Stock Solutions

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07579962 NOT_YET_RECRUITING
Vascular Malformations
Institute of Oncology Ljubljana
 2026-06-30 PHASE2
NCT05675410 RECRUITING
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
National Cancer Institute (NCI)
 2023-05-11 PHASE3
NCT04685616 RECRUITING
Hodgkin Lymphoma
University College, London
 2022-04-14 PHASE3
NCT02582697 RECRUITING
Germ Cell Tumor
University of Sydney
 2014-02 PHASE3
NCT06691009 NOT_YET_RECRUITING
Malignant Pleural Effusion
Assiut University
 2024-12-10
NCT03067181 RECRUITING
Childhood Extracranial Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Germ Cell Tumor; Malignant Germ Cell Tumor; Malignant Ovarian Teratoma; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage I Testicular Choriocarcinoma AJCC v6 and v7; Stage I Testicular Embryonal Carcinoma AJCC v6 and v7; Stage I Testicular Seminoma AJCC v6 and v7; Stage I Testicular Yolk Sac Tumor AJCC v6 and v7; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage II Testicular Choriocarcinoma AJCC v6 and v7; Stage II Testicular Embryonal Carcinoma AJCC v6 and v7; Stage II Testicular Yolk Sac Tumor AJCC v6 and v7; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage III Testicular Choriocarcinoma AJCC v6 and v7; Stage III Testicular Embryonal Carcinoma AJCC v6 and v7; Stage III Testicular Yolk Sac Tumor AJCC v6 and v7; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
Children's Oncology Group
 2017-05-25 PHASE3

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