MK-2206 2HCl

For research use only.

Catalog No.S1078

1100 publications

MK-2206 2HCl Chemical Structure

CAS No. 1032350-13-2

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.

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Selleck's MK-2206 2HCl has been cited by 1100 publications

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Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NIrGR3FEgXSxdH;4bYMhSXO|YYm= NF\TNpo{KM7:TR?= MWS3NkBp MmLXSG1UVw>? MknITY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25? NWnlSYc1OjB3N{GwOlk>
A431 MlXDT4lv[XOnIFHzd4F6 NYfzOG5CPSEQvF2= NVv2dnptPSCq Moe0SG1UVw>? NFLTPYlUfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? NHX5WZczODV5MUC2PS=>
HepG2 MlPCR5l1d3SxeHnjJGF{e2G7 MWOxNEDPxE1? NIPHU3MzPCCq MYfEUXNQ MkTIV4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni MWOyNVIxPTl{NR?=
Sk-Hep1 NW\p[45DS3m2b4TvfIlkKEG|c3H5 M4nt[FExKM7:TR?= M17WblI1KGh? NEPXR4ZFVVOR NEnmRYdU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> NETofZgzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) NH;ROYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP3TJA{KM7:TR?= Mnn6OUBl MYjEUXNQ NWDObVFuUUN3ME2wMlE1KM7:TR?= NXO4flViOjF{OEmyOlc>
K1 cells harbored PIK3CA (E542K+/+) MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWzJO69VQ>? M1vYcFUh\A>? NV3iOVhlTE2VTx?= NHrVUJhKSzVyPUCuOVIh|ryP MkLZNlEzQDl{Nke=
FTC133 cells harbored PTEN (allele deletion and R130+) MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7NfHhFOyEQvF2= NYnUNnVWPSCm NFS5bppFVVOR NYnvNm1tUUN3ME2wMlE5KM7:TR?= M1q1XVIyOjh7Mk[3
C643 cells harbored HRAS (G13R+/−) NWLyZYJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\uXWI{KM7:TR?= NWfzdoFNPSCm NHHuN3JFVVOR MlzOTWM2OD1yLkK3JO69VQ>? MnX2NlEzQDl{Nke=
Hth7 cells harbored NRAS (Q61R+/−) M3XLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXmN{DPxE1? NWTlSmRGPSCm MXrEUXNQ NULFV3F1UUN3ME20MlUh|ryP NX\rc3dbOjF{OEmyOlc>
TPC1 cells harbored RET/PTC1 rearrangement NYnINWZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OyPFMh|ryP Mn20OUBl M3\5ZmROW09? MVjJR|UxRTBwNUmg{txO MXOyNVI5QTJ4Nx?=
Hth74 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\RN{DPxE1? MUm1JIQ> M2rneGROW09? MYDJR|UxRTJwMUmg{txO Mk[0NlEzQDl{Nke=
KAT18 NV7pcpdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP3N{DPxE1? Mo\vOUBl NIDRcFZFVVOR MYPJR|UxRTRwNkKg{txO NGLoc5IzOTJ6OUK2Oy=>
SW1736 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVyxNFAh|ryP MVi1JIQ> NFO4TYJFVVOR MkLRTWM2OD12Nz61OkDPxE1? M4fNc|IyOjh7Mk[3
WRO NWHve3F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXUXnYyODByIN88US=> MWC1JIQ> MnixSG1UVw>? MoTsTWM2OD5zMECwJO69VQ>? M3GxNFIyOjh7Mk[3
TAD2 NWfJW2hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWxNFAxKM7:TR?= NGjqbIs2KGR? M2XwPWROW09? NHfRWZpKSzVyPkGwNFAh|ryP NGDG[oozOTJ6OUK2Oy=>
LN229 NHf2d5FCeG:ydH;zbZMhSXO|YYm= NIO2eHYxNjVizszN MX:2NEBp M3v3TWROW09? MY\BeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? NYrG[YJoOjJyNUe5NVQ>
T98G MVfBdI9xfG:|aYOgRZN{[Xl? MWiwMlUh|ryP MYS2NEBp MUfEUXNQ NVzpOJNWSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= NXTCZXZTOjJyNUe5NVQ>
HC11 NFvaXZhHfW6ldHnvckBCe3OjeR?= NGj3OZcyOCEQvF2= M{H0bFI1KGh? MULEUXNQ MnHSTY5pcWKrdIOg{tIu[2G|ZXnuJIFv\CCDRGLQJJN6dnSqZYPpdy=> MXWyNlQzPjZ{MR?=
MOLT-4 MUXDfZRwfG:6aXOgRZN{[Xl? NVvMZ443OTBizszN MX[0PEBp NHvR[nlFVVOR NFrUZlBKSzVyPUGuO-KBkc7:TR?= NUHHcGpYOjJ4MUSyOFM>
CEM-R NXnrXopNS3m2b4TvfIlkKEG|c3H5 Mlr0NVAh|ryP MUK0PEBp MXHEUXNQ NHrYemNKSzVyPUOuN-KBkc7:TR?= NH34U3EzOjZzNEK0Ny=>
CEM-S NH3JSIxEgXSxdH;4bYMhSXO|YYm= NHy0PHoyOCEQvF2= NGf0TnI1QCCq NVe1Wm85TE2VTx?= NIKzOXJKSzVyPUWuNgKBkc7:TR?= MV[yNlYyPDJ2Mx?=
MOLT-4 MnvaSpVv[3Srb36gRZN{[Xl? MkX6NVAh|ryP MWSyOEBp M3vlTmROW09? MVTCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm MXKyNlYyPDJ2Mx?=
MOLT-4 MWHGeY5kfGmxbjDBd5NigQ>? MVy05qCK|ryP MVm0JIg> NYfsRY1GTE2VTx?= M4jCRWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFOzRU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? M{T6W|IzPjF2MkSz
CEM-R NV3hd5lqTnWwY4Tpc44hSXO|YYm= MXG05qCK|ryP MVq0JIg> MXHEUXNQ NYX2PWJKUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|RCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ NHPwPHEzOjZzNEK0Ny=>
CEM-S NVHjdZY4TnWwY4Tpc44hSXO|YYm= NULn[HlsPOLCid88US=> M2C0VVQhcA>? MUfEUXNQ NGG1[lRKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOWEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? MYSyNlYyPDJ2Mx?=
HepG2 cell NUD6T5ZVU2mwYYPlJGF{e2G7 MVWyNEDPxE1? MorVNlQhcA>? NH2xeIdFVVOR MnXCSI94dnKnZ4XsZZRmeyC2aHWgdIhwe3Cqb4L5cIF1cW:wIH;mJGFMXA>? NYHSRYMxOjN5OUezNVk>
HepG2 cell MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNemw{OCEQvF2= MlyyNlQhcA>? NV7tXHlwTE2VTx?= M4C1eGlvcGmkaYTzJINmdGxiZ4Lve5Rp NHrFZY8zOzd7N{OxPS=>
HepG2 cell MlnTRZBweHSxc3nzJGF{e2G7 NUjW[VV[OjBizszN MXOyOEBp NHTBWY5FVVOR MXLJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NI\UNnYzOzd7N{OxPS=>
GEO NH7wPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnlWYY2ODBibl2= NHftSmU4OiCq MV3EUXNQ M{\0VWlvcGmkaYTzJINmdGxiZ4Lve5Rp MkHMNlQ2QDF{M{G=
CNE-1 NFKzSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWxNEDPxE1? M4nzUVk3KGh? NGLGNXZFVVOR M4TyfWlEPTB;Mj65OkDPxE1? MWCyOVM{Pjl{NR?=
CNE-2 M17EO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3FNVAh|ryP Mlr1PVYhcA>? M2nJeWROW09? M3XoPWlEPTB;ND61N{DPxE1? MUOyOVM{Pjl{NR?=
HONE-1 NIexVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jGclExKM7:TR?= M2PTe|k3KGh? NHTPNVlFVVOR NH;Z[FBKSzVyPUOuN|ch|ryP M{HKSlI2OzN4OUK1
SUNE-1 NVPDfYlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ZNVAh|ryP MnmwPVYhcA>? NGPwTZRFVVOR Mn6wTWM2OD1yLkWyJO69VQ>? MoPKNlU{OzZ7MkW=
CNE-2 NWHOZ4lvTnWwY4Tpc44hSXO|YYm= MVixNEDPxE1? NYP5XYRZPDhiaB?= MY\EUXNQ MVrJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy MlfPNlU{OzZ7MkW=
HONE-1 M2DDc2Z2dmO2aX;uJGF{e2G7 NFXZUYoyOCEQvF2= Mn[2OFghcA>? NHnvemtFVVOR NX;HSoVJUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= MnnVNlU{OzZ7MkW=
NEC8 M{Ozemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV23[IJKUUN3ME2wMlA6PjVzIN88US=> MYLTRW5ITVJ?
P12-ICHIKAWA NFPpSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvwTWM2OD1yLkGxOlIh|ryP MV3TRW5ITVJ?
MDA-MB-175-VII Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPLTWVvUUN3ME2wMlE{PzN6IN88US=> NEnHe5dUSU6JRWK=
AsPC-1 NUPZdnNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMkKxNlIh|ryP NFnr[3pUSU6JRWK=
T47D NH3PSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1yxRWlEPTB;MD6yPFI2KM7:TR?= M3LKZnNCVkeHUh?=
HH M4rKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHWTlNKSzVyPUCuN|AzQDNizszN M330VHNCVkeHUh?=
MOLT-16 NUXUeVc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rjdWlEPTB;MD6zNFMzKM7:TR?= NGiydlNUSU6JRWK=
ES5 MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TYfGlEPTB;MD6zOFQ2PSEQvF2= M1jWcHNCVkeHUh?=
RS4-11 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\rR|lHUUN3ME2wMlM1PjFizszN NXjhUHhHW0GQR1XS
KARPAS-45 M3i3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ZTWM2OD1yLkO3N|IyKM7:TR?= Mlu0V2FPT0WU
NCI-H720 NYK1UnFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1foS2lEPTB;MD6zO|Y4QSEQvF2= M1XaWHNCVkeHUh?=
H9 NV\wd25QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LRUmlEPTB;MD6zPFg5OyEQvF2= MUjTRW5ITVJ?
EFM-19 NH3X[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPITWM2OD1yLkS0NFEh|ryP NITsV4pUSU6JRWK=
SBC-1 M{f3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml76TWM2OD1yLkS0NFM2KM7:TR?= MlTqV2FPT0WU
A4-Fuk NX7tflFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfMRlNCUUN3ME2wMlQ3QDZ6IN88US=> MoLoV2FPT0WU
NCI-H1563 NYLhdlV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6yTWM2OD1yLkS4NVg6KM7:TR?= MkHxV2FPT0WU
HCC1419 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H5XmlEPTB;MD60PFg6OiEQvF2= M3jtOXNCVkeHUh?=
H-EMC-SS NEXL[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nL[2lEPTB;MD60PVk{QSEQvF2= Ml35V2FPT0WU
BHT-101 M36zW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq0cWxKSzVyPUCuOVI6PjFizszN NHLI[|lUSU6JRWK=
IGROV-1 M1PPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnMV3o6UUN3ME2wMlU2OjR7IN88US=> NF;HN2tUSU6JRWK=
HGC-27 Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD1yLkW2O|g{KM7:TR?= NWrNO|QxW0GQR1XS
MDA-MB-361 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmCwTWM2OD1yLkW3O|YyKM7:TR?= MVrTRW5ITVJ?
KE-37 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\2OWlEPTB;MD61PFI3KM7:TR?= MmTHV2FPT0WU
HCC70 M1nsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwNUm4Nlch|ryP MVTTRW5ITVJ?
LNCaP-Clone-FGC MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO4[5lKSzVyPUCuOlExPDhizszN M{D3bXNCVkeHUh?=
HAL-01 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu0S4FKSzVyPUCuOlIyOyEQvF2= MWfTRW5ITVJ?
HT MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrlTWM2OD1yLk[zNlM6KM7:TR?= M{PVb3NCVkeHUh?=
MDA-MB-415 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjLcWZKSzVyPUCuOlM3OjZizszN MlTOV2FPT0WU
NOS-1 NEjBZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPyTWM2OD1yLk[zO|I{KM7:TR?= M1fFVHNCVkeHUh?=
DU-145 NHS4WYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:zbGlEPTB;MD62OFc1PSEQvF2= MUDTRW5ITVJ?
OCUB-M NFvjeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwN{C5OlYh|ryP NV\T[4drW0GQR1XS
VA-ES-BJ MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGUmlEPTB;MD63N|AzPSEQvF2= NHfVeYlUSU6JRWK=
J-RT3-T3-5 NF\JdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnI[pBKSzVyPUCuO|Q1ODNizszN MX7TRW5ITVJ?
MOLT-4 MlnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLHTWM2OD1yLkiwOVgzKM7:TR?= MlPOV2FPT0WU
NB7 NFjFOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfxWllKSzVyPUCuPFI1OTFizszN MnLJV2FPT0WU
L-363 M4DOcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoToTWM2OD1yLkizOFQzKM7:TR?= M1\2fnNCVkeHUh?=
NKM-1 M{DFUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnNcoFKSzVyPUCuPFYzPTNizszN MYnTRW5ITVJ?
HOP-92 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LzcGlEPTB;MD64O|IzOyEQvF2= MVLTRW5ITVJ?
OAW-42 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwOEi3NkDPxE1? NF\6UWtUSU6JRWK=
HuO9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnxOZNKSzVyPUCuPVI4PTFizszN NH\YcVFUSU6JRWK=
MFE-280 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\mTWM2OD1yLkm2OFY2KM7:TR?= MWPTRW5ITVJ?
EM-2 NX;4OZF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULCO5VYUUN3ME2wMlk4QTN7IN88US=> MnnkV2FPT0WU
NCI-H520 NVz1eWVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrMNWJCUUN3ME2wMlk5PTl{IN88US=> M33XR3NCVkeHUh?=
LB2241-RCC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnBR45zUUN3ME2wMlk6PzN2IN88US=> MWrTRW5ITVJ?
SK-NEP-1 M2LpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P5cGlEPTB;MT6xOFQ5PSEQvF2= MYLTRW5ITVJ?
LXF-289 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7ue3pWUUN3ME2xMlE4OTV4IN88US=> M122VHNCVkeHUh?=
EPLC-272H M1KzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M122UGlEPTB;MT6xO|I2PiEQvF2= M1PafXNCVkeHUh?=
COLO-684 M17nTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPzTWM2OD1zLkKzO|I2KM7:TR?= MmfqV2FPT0WU
ES1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\mV2lEPTB;MT6yOFA3PSEQvF2= NIfPVYZUSU6JRWK=
DOHH-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ie2lEPTB;MT6yPFIxOyEQvF2= NIXaWoFUSU6JRWK=
CTB-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTiTWM2OD1zLkK4PVkh|ryP MkTOV2FPT0WU
G-401 M3vNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwMkm3PVUh|ryP MYnTRW5ITVJ?
LoVo NWPPWlJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHjVlhuUUN3ME2xMlMzPTN2IN88US=> MkXtV2FPT0WU
Ramos-2G6-4C10 NGnR[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDFNJdKSzVyPUGuN|M4ODFizszN NVG4fGxJW0GQR1XS
MFM-223 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfVTWM2OD1zLkO0OFYyKM7:TR?= MkC2V2FPT0WU
PA-1 M4fyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfMTWM2OD1zLkO1NlY2KM7:TR?= M{j1bHNCVkeHUh?=
697 NV;qUHZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXmPI5KSzVyPUGuN|c3OTZizszN MVHTRW5ITVJ?
QIMR-WIL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrKbpJQUUN3ME2xMlQ6OTF4IN88US=> NVv0cYs4W0GQR1XS
HOS NVXm[o1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHoU4NRUUN3ME2xMlQ6PTV6IN88US=> M1zodXNCVkeHUh?=
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RPMI-8226 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfLO5R[UUN3ME2yMlYzQTV|IN88US=> NUHaNmpqW0GQR1XS
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RT-112 M3rjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPy[Is{UUN3ME2zMlUzOzh6IN88US=> NWf1Xm5wW0GQR1XS
DMS-114 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTNwNkKyO|gh|ryP MmfqV2FPT0WU
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BT-20 NY\BZ|U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\tTWM2OD13LkKxN|U{KM7:TR?= NUTCb5BIW0GQR1XS
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CAL-27 M2PRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXJU4hWUUN3ME21MlQ3OzN7IN88US=> NFi0eWJUSU6JRWK=
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RPMI-2650 M4TndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjTfGNqUUN3ME21MlY3OTl7IN88US=> NFf5O2lUSU6JRWK=
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Becker M1\XT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy0eJNKSzVyPUWuPFY1PzJizszN Ml3NV2FPT0WU
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D-263MG NXyyb3VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr5T25JUUN3ME22MlQ2OTZ7IN88US=> MWjTRW5ITVJ?
SNB75 M33jOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fmTGlEPTB;Nj62NFE1OyEQvF2= NYnFd|dJW0GQR1XS
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CHL-1 M4DX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZwOECwO|kh|ryP MVnTRW5ITVJ?
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HCC1954 M1G2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPOW4hKSzVyPUiuOFUyODRizszN Mn3LV2FPT0WU
SF126 NV7SOXlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPqeVhKSzVyPUiuOFU6OzZizszN MVjTRW5ITVJ?
LB996-RCC M3X6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3kbIdlUUN3ME24MlU{OjV5IN88US=> M13SfnNCVkeHUh?=
SKG-IIIa MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHuWVZKSzVyPUiuOlMxPjlizszN M{DyNHNCVkeHUh?=
NCI-SNU-1 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3YNpU1UUN3ME24MlY1PjR|IN88US=> NV\oOohjW0GQR1XS
LB771-HNC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3IO3hKSzVyPUiuOlQ3QTZizszN MkfaV2FPT0WU
SCC-4 NXv1dmRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnnc5NiUUN3ME24MlY5OjF7IN88US=> M{LBVnNCVkeHUh?=
CAMA-1 M3XmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHiVohLUUN3ME24Mlc4OTR4IN88US=> M1\oVnNCVkeHUh?=
D-502MG NG\zb|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRThwN{i2Nlkh|ryP NIfUVIRUSU6JRWK=
ESS-1 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzhO2ozUUN3ME24Mlg5PzB2IN88US=> NH\JdFBUSU6JRWK=
HEC-1 M3vWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjDSFlPUUN3ME24Mlg6QDZ4IN88US=> MnvHV2FPT0WU
NB10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTlwMEKyNlQh|ryP Mo[4V2FPT0WU
8505C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3iS4hKSzVyPUmuNFQzOzJizszN M2rXXnNCVkeHUh?=
EFO-27 NGjWNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfne4xKSzVyPUmuNVY1OTJizszN Mn31V2FPT0WU
HN MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi0[3FKSzVyPUmuNVY3OjhizszN NYDHe5ZkW0GQR1XS
DSH1 Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTVTWM2OD17LkKwPFch|ryP M4C2ZnNCVkeHUh?=
NBsusSR M2jaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTlwMke0NFIh|ryP M4rKSHNCVkeHUh?=
LS-123 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPVbINKSzVyPUmuN|E4PjFizszN Mo\JV2FPT0WU
SHP-77 NF7D[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjKTWM2OD17LkO5PVM2KM7:TR?= NH7BemFUSU6JRWK=
ACN MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\RcZp3UUN3ME25MlU{Ojd5IN88US=> NIHzTnBUSU6JRWK=
U251 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr0[m9iUUN3ME25MlY2PTR2IN88US=> MmDLV2FPT0WU
A431 NH7vUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXrTWM2OD17LkiwNlM5KM7:TR?= M3XQdHNCVkeHUh?=
5637 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7rcVdKSzVyPUmuPFQ6QDRizszN NVLRRoFjW0GQR1XS
MDA-MB-157 NFrxe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL2[JQ3UUN3ME25MlkzQDd6IN88US=> MoC4V2FPT0WU
A101D MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTlwOUm5O|Qh|ryP NXq2TVlQW0GQR1XS
YKG-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz2[nZwUUN3ME2xNE4zODB4IN88US=> MXTTRW5ITVJ?
LAN-6 NXvMc3p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTBNlUyUUN3ME2xNE4zOTZ2IN88US=> NH3ieGRUSU6JRWK=
OVCAR-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTFyLkK0N|Mh|ryP NI\oW2dUSU6JRWK=
A549 NIfmWmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq0TWM2OD1zMD6zPVc{KM7:TR?= M{ThWXNCVkeHUh?=
no-11 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTZTWM2OD1zMD60N|U{KM7:TR?= M1joVnNCVkeHUh?=
SF539 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFyLkmwOFEh|ryP Mn22V2FPT0WU
A388 MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP2VnQxUUN3ME2xNU4{QDl5IN88US=> MmrhV2FPT0WU
DEL NGfa[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInvXmlKSzVyPUGxMlQzPCEQvF2= MmD6V2FPT0WU
SW954 NYnseYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFzLkS2Olgh|ryP NUjaUFVxW0GQR1XS
TK10 NGCw[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFzLkWyO|Eh|ryP MkXoV2FPT0WU
SW756 NGf5NWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor5TWM2OD1zMT61Nlk1KM7:TR?= NUjLZW9GW0GQR1XS
PC-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;mTWM2OD1zMT61O|Y1KM7:TR?= M3TQSHNCVkeHUh?=
ONS-76 NFHCcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PrWWlEPTB;MUGuOlM3KM7:TR?= Mn7TV2FPT0WU
A427 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm0TWM2OD1zMT63NFk{KM7:TR?= MWPTRW5ITVJ?
MEG-01 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoroTWM2OD1zMT63OVA6KM7:TR?= MXPTRW5ITVJ?
BB30-HNC M1uz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nPdmlEPTB;MUGuO|k5OiEQvF2= M{Lh[nNCVkeHUh?=
NCI-H1299 MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP1VJRKSzVyPUGxMlgxQTNizszN M33O[nNCVkeHUh?=
GCT MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFzLkiyNlgh|ryP NVLGepZyW0GQR1XS
D-247MG M2Tyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fXcmlEPTB;MUGuPVY3OyEQvF2= MnXOV2FPT0WU
CFPAC-1 NXr1SYg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFzLkm3PFIh|ryP NXn5VpRiW0GQR1XS
EKVX MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f2UmlEPTB;MUKuNFMyOyEQvF2= NFrQUZpUSU6JRWK=
CAL-51 NXHsfHlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHqN2hnUUN3ME2xNk4xPzF4IN88US=> MWHTRW5ITVJ?
BB49-HNC MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P0dWlEPTB;MUKuNVE4PyEQvF2= MnG1V2FPT0WU
RPMI-7951 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2xT5dKSzVyPUGyMlE5PTRizszN MlLiV2FPT0WU
RH-1 MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;2TWM2OD1zMj6yNVg1KM7:TR?= NV;ESXdJW0GQR1XS
BCPAP NYrCd2pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF{LkS3OFkh|ryP NFH2UItUSU6JRWK=
GCIY MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HvXWlEPTB;MUKuOVIxQSEQvF2= NF;lTWJUSU6JRWK=
KNS-81-FD M4D2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrRNnN4UUN3ME2xNk42QDZ7IN88US=> MXrTRW5ITVJ?
KYSE-140 M{LE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF{Lki1PVUh|ryP Mom3V2FPT0WU
Ca-Ski NWLMNJgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnafYxIUUN3ME2xNk46ODRzIN88US=> MYrTRW5ITVJ?
TGBC1TKB NHi5TYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXruRlRbUUN3ME2xNk46OTF3IN88US=> MWnTRW5ITVJ?
HCC1187 NU[3S|BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX2TWM2OD1zMz6xPVEzKM7:TR?= MlzJV2FPT0WU
SJSA-1 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7QTWM2OD1zMz6yN|I4KM7:TR?= NWHJNnJRW0GQR1XS
CTV-1 M13LUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfTZ|FKSzVyPUGzMlM1PSEQvF2= MYTTRW5ITVJ?
WM-115 NHK1SXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;vcGlEPTB;MUOuOlQ5OyEQvF2= M4rQPXNCVkeHUh?=
CHP-212 NV7GR3VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfydlB7UUN3ME2xN{46PzN7IN88US=> NXfidm1SW0GQR1XS
SCC-15 NVrtRYV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\UfZdzUUN3ME2xN{46Pzd3IN88US=> Ml;TV2FPT0WU
BPH-1 NGjnRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrFTWM2OD1zND6xOlY1KM7:TR?= NGK1dW9USU6JRWK=
SW780 NY\SSGpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DzTGlEPTB;MUSuOVAzPSEQvF2= M4O0enNCVkeHUh?=
NCI-H2291 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF2LkW4O|gh|ryP MYnTRW5ITVJ?
JEG-3 NULHbow1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTwV2tVUUN3ME2xOE43OzJ4IN88US=> Ml3LV2FPT0WU
CAL-120 MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXETWM2OD1zND63NFI4KM7:TR?= NU\5SHZmW0GQR1XS
NCI-H23 M{nw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnkTWM2OD1zND63PVk4KM7:TR?= MljJV2FPT0WU
MS-1 NVrqZmtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPMTWM2OD1zND65OlEyKM7:TR?= MmS2V2FPT0WU
PC-14 MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXFTWM2OD1zND65OlU1KM7:TR?= MXHTRW5ITVJ?
D-283MED NYfzcnJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnxTWM2OD1zNT6wNVEyKM7:TR?= NI\td4FUSU6JRWK=
OE19 NXvVdnpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF3LkG1OFEh|ryP NHfEdXpUSU6JRWK=
CAS-1 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHLTWM2OD1zNT60NVg1KM7:TR?= NGHjSFdUSU6JRWK=
NCI-H727 NHj4WJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDZd4dKSzVyPUG1MlQzOjFizszN MVrTRW5ITVJ?
SiHa MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnHTWM2OD1zNT63OVk1KM7:TR?= NUXWUnBnW0GQR1XS
BFTC-905 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37jeGlEPTB;MUWuO|Y6PCEQvF2= NVq1Z|ZyW0GQR1XS
MDA-MB-453 NGPYSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF4LkG2OFIh|ryP M{DDV3NCVkeHUh?=
HuP-T3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH1TWM2OD1zNj62N|c{KM7:TR?= NUfLVppsW0GQR1XS
SK-LU-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF4Lk[5OVYh|ryP M160d3NCVkeHUh?=
Detroit562 NITTNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv3OZdYUUN3ME2xOk44OzF6IN88US=> MkO0V2FPT0WU
HCC1569 NEHFbHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF4LkizN|ch|ryP NFjjenRUSU6JRWK=
SK-MES-1 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTKTpJKSzVyPUG2Mlg1OTlizszN MVvTRW5ITVJ?
BB65-RCC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYTWM2OD1zNz6wOFc6KM7:TR?= MXzTRW5ITVJ?
LOXIMVI M{nt[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S2U2lEPTB;MUeuNFcxPyEQvF2= MWjTRW5ITVJ?
SW1783 NXr5c5F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjFVHBKSzVyPUG3MlEzQCEQvF2= MV7TRW5ITVJ?
NH-12 NXG1SXJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXDTWM2OD1zNz6zN|A{KM7:TR?= MkLDV2FPT0WU
UACC-257 M2LNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;mXGlEPTB;MUeuOVUyOiEQvF2= Mmm2V2FPT0WU
KOSC-2 NFHBZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHwfJVKSzVyPUG3MlY4PTdizszN MWnTRW5ITVJ?
KG-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF5Lk[5N|ch|ryP MmDBV2FPT0WU
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MHH-NB-11 NHHjeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr6ZZJKSzVyPUG3Mlk3PzNizszN M2DHbnNCVkeHUh?=
EW-1 NU[5[I1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[5bmNiUUN3ME2xPE4yOzh{IN88US=> NYD4V|RwW0GQR1XS
CAL-85-1 NI[wd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF6LkKzOVch|ryP NITTbppUSU6JRWK=
639-V MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILvfnlKSzVyPUG4MlM{PTRizszN MkC1V2FPT0WU
C32 NX7ZVXpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzNTWM2OD1zOD60O|I4KM7:TR?= MVXTRW5ITVJ?
KM-H2 M1job2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofUTWM2OD1zOD61NlMzKM7:TR?= MnHZV2FPT0WU
A253 NXHyS4F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXJXYJKSzVyPUG4MlczQDZizszN M37wVnNCVkeHUh?=
NCI-N87 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH24XWVKSzVyPUG4MlkxODhizszN NGjFfIdUSU6JRWK=
8-MG-BA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLFTWM2OD1zOT6wOlQ3KM7:TR?= NWPsW5FsW0GQR1XS
GI-ME-N M4C5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHs[WV{UUN3ME2xPU4yPTR4IN88US=> NGK5NmNUSU6JRWK=
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TE-8 NUXnSmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF7LkOwNlQh|ryP MV\TRW5ITVJ?
KYSE-270 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7MU5NKSzVyPUKwMlAzOTdizszN M1zWSXNCVkeHUh?=
HL-60 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvTWM2OD1{MD6wPVQyKM7:TR?= M1fvdXNCVkeHUh?=
Mo-T MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfudmIyUUN3ME2yNE4yPjZ3IN88US=> MXHTRW5ITVJ?
NCI-H1355 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HrdWlEPTB;MkCuN|M4PCEQvF2= NH;BPWxUSU6JRWK=
HT-1080 NX\TPZNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPQPIZtUUN3ME2yNE42PDl5IN88US=> NXPRXZVnW0GQR1XS
MIA-PaCa-2 NXPNPHFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjJSotZUUN3ME2yNE43QDh|IN88US=> NVPpNoxYW0GQR1XS
NCI-H441 NEHhTlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTUeI5KSzVyPUKwMlc{PzlizszN NIXGTnZUSU6JRWK=
LCLC-97TM1 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXzTWM2OD1{MD64NVM1KM7:TR?= MoOxV2FPT0WU
HT-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j2S2lEPTB;MkGuOVY{OSEQvF2= MoP1V2FPT0WU
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LK-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJzLkW5OVMh|ryP M4jQW3NCVkeHUh?=
CW-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJzLk[wOlkh|ryP M4PYdnNCVkeHUh?=
KYSE-510 NEXtNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ER2hKSzVyPUKxMlYxQTVizszN NUHvWJNWW0GQR1XS
CGTH-W-1 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULmeHZZUUN3ME2yNU44OTZ4IN88US=> NX3oTVdGW0GQR1XS
NCI-H661 NV;VSolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXkb3NKSzVyPUKyMlA{PCEQvF2= NVPOZ4djW0GQR1XS
KU-19-19 NX3HcpkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XrWmlEPTB;MkKuNVY6PyEQvF2= MUDTRW5ITVJ?
NCI-H2122 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnOTWM2OD1{Mj6yOFMzKM7:TR?= M4rxVXNCVkeHUh?=
NCI-H526 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnYTGNwUUN3ME2yNk4{QDl3IN88US=> Mnq5V2FPT0WU
NCI-H1650 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX1dmJ7UUN3ME2yNk44PjRizszN NGjWVYxUSU6JRWK=
AM-38 M2fndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq3TWM2OD1{Mj64Olg6KM7:TR?= NXj3XIZFW0GQR1XS
NCI-H2405 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:4TWM2OD1{Mz6yOVM{KM7:TR?= MnK1V2FPT0WU
M14 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHCTWM2OD1{Mz60NFg5KM7:TR?= NFHFUoZUSU6JRWK=
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DoTc2-4510 NYPvSIxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrxeFhKSzVyPUi0MlIyQDVizszN Mme4V2FPT0WU
NCI-H1581 M2\GRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjRd5ZqUUN3ME24OU41PjRzIN88US=> NVj2fmw{W0GQR1XS
KARPAS-299 NH[0ZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;vZ2FbUUN3ME24Ok4yQTd5IN88US=> NYTJUIk3W0GQR1XS
IST-MEL1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvIWpRKSzVyPUi2Mlg5PzJizszN M125ZXNCVkeHUh?=
KP-N-YS NVnCe45kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLaTWM2OD16OT65NFI5KM7:TR?= NE[xeHFUSU6JRWK=
KYSE-410 NUjFZppYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS2WolKSzVyPUmxMlQxPDJizszN MUfTRW5ITVJ?
TE-10 M3jtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnUPXlKSzVyPUmxMlU3OTFizszN NVK1OWlbW0GQR1XS
SK-MEL-1 NXjQc5NDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTl{LkmxNFYh|ryP Mm[zV2FPT0WU
COLO-792 NUPjPG8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTtTWM2OD17NT6yOVY1KM7:TR?= NICwN3hUSU6JRWK=
SCH M3LEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTWdmFzUUN3ME25Ok4{QDd5IN88US=> M4XzXXNCVkeHUh?=
NCI-H1792 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPjU3FKSzVyPUm2Mlg6QTJizszN MVjTRW5ITVJ?
NCI-H2029 M3PBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC5UWZlUUN3ME25Ok46PTZ4IN88US=> MXPTRW5ITVJ?
SW684 Mm\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfyUGxKSzVyPUm4MlY3PTRizszN M3OwenNCVkeHUh?=
NCI-H209 NVi5bYJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP6e4hKSzVyPUGwNE4yOjFizszN M4rmTXNCVkeHUh?=
HLE NXnSdIdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfHdIVTUUN3ME2xNFUvOjh{IN88US=> NUS2U5pYW0GQR1XS
GOTO M3q3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;kR3ZKSzVyPUGwO{44PzdizszN MoToV2FPT0WU
NCI-H1793 NV\TN3dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLNfnFKSzVyPUGwPU4zQCEQvF2= M2\IZXNCVkeHUh?=
D-392MG NYfTUVhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFzNz6zPVgh|ryP M{nUZnNCVkeHUh?=
SW1990 NXXROIZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTHb5hKSzVyPUGyNE46PTFizszN M1rye3NCVkeHUh?=
ML-2 NILR[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGwZXFVUUN3ME2xNlEvPjd4IN88US=> M2DYPXNCVkeHUh?=
NCI-H2452 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX4TWM2OD1zMkKuNlEh|ryP MV;TRW5ITVJ?
SK-MEL-30 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF{Mz6yOFQh|ryP MlHyV2FPT0WU
SN12C M3jUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXOdnd4UUN3ME2xNlQvOTd4IN88US=> NYi4ZYFVW0GQR1XS
NCI-H1770 NFnHUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;WPJdKSzVyPUGyOU42OTRizszN Mlv4V2FPT0WU
SF268 NYD0b3psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHWXXFyUUN3ME2xNlYvOTV6IN88US=> MXzTRW5ITVJ?
BALL-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGyTWM2OD1zMk[uNlMh|ryP NIjubnJUSU6JRWK=
COLO-679 NHLxTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPndVlKSzVyPUGyOk44PTNizszN M{jHVXNCVkeHUh?=
A2780 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DTXWlEPTB;MUK4Mlk5QCEQvF2= MnXEV2FPT0WU
NCI-H1651 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXtTWM2OD1zM{GuNlQ{KM7:TR?= NF;l[ZpUSU6JRWK=
NCI-H2087 M1\Wemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:3eINKSzVyPUGzNU41QDNizszN NULOdohxW0GQR1XS
U-87-MG NXzoW|NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXHUpZKSzVyPUGzN{43ODRizszN MljVV2FPT0WU
LB2518-MEL NF7ocnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXSfmVKSzVyPUGzOU46QTNizszN MUTTRW5ITVJ?
HCT-116 NWD4cW96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjl[YdKSzVyPUGzO{4zOTdizszN MUTTRW5ITVJ?
Ca9-22 M1vIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj4fFhqUUN3ME2xN|kvQDN|IN88US=> NGnn[ZdUSU6JRWK=
COR-L88 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nER2lEPTB;MUSyMlE1KM7:TR?= Mn3pV2FPT0WU
CP50-MEL-B MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF2ND61NFEh|ryP NFLvVGRUSU6JRWK=
OVCAR-8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz2bHdFUUN3ME2xOFUvPjN4IN88US=> NEDV[FFUSU6JRWK=
SK-MEL-3 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HYZWlEPTB;MUS3Mlg4QCEQvF2= NEL6SG1USU6JRWK=
GT3TKB MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH60Ro1KSzVyPUG0PU46OjhizszN NEHHOVdUSU6JRWK=
KYSE-450 NYDQfm9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHwTWM2OD1zNUGuOVM6KM7:TR?= M3\TVHNCVkeHUh?=
CAPAN-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;0eHZCUUN3ME2xOVMvODZ2IN88US=> NWjlR3QxW0GQR1XS
BEN M4\ZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfuXlV5UUN3ME2xOVMvQTJ6IN88US=> MnP6V2FPT0WU
NCI-H1304 NWLqe296T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXiTWM2OD1zNUSuOlk1KM7:TR?= M3HtPHNCVkeHUh?=
KU812 M1zXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPPTWM2OD1zNUiuOlc1KM7:TR?= MV7TRW5ITVJ?
Capan-2 NGTrUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG0TWM2OD1zNkCuOVU{KM7:TR?= NXXIfFVNW0GQR1XS
A673 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTqSnd6UUN3ME2xOlEvPzB3IN88US=> MWfTRW5ITVJ?
SAS Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF4Mj62O|gh|ryP MVLTRW5ITVJ?
NY NEDL[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX0TWM2OD1zNkWuN|E1KM7:TR?= NWTHfJp3W0GQR1XS
HCE-4 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorxTWM2OD1zNk[uPFQ2KM7:TR?= NX\QXlhzW0GQR1XS
MDA-MB-231 NFnOcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfOe2pKSzVyPUG3O{42ODNizszN M1W5fnNCVkeHUh?=
no-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF5OD6xN|Qh|ryP Ml7mV2FPT0WU
MZ7-mel NIftZ2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\kPFlKSzVyPUG3PE41PjdizszN NGno[3BUSU6JRWK=
NCI-H82 NH7mNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnwbYFKSzVyPUG4NE4yPjVizszN NXvTNIVNW0GQR1XS
CAL-72 NVfzXYg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrmfpdKSzVyPUG4OU4xPTRizszN MoXuV2FPT0WU
NCI-SNU-5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\oTWM2OD1zOE[uPFQh|ryP MUXTRW5ITVJ?
OVCAR-4 NHv6NXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPGcHZDUUN3ME2xPFgvOzN|IN88US=> M{DiUHNCVkeHUh?=
SCC-9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ToVGlEPTB;MUmxJO69VQ>? NWrPNWRDW0GQR1XS
KYSE-150 M3GwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF7MT64PFgh|ryP M1rwXnNCVkeHUh?=
HT-29 NEjrWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTZTWM2OD1{MEGuNlEzKM7:TR?= MYPTRW5ITVJ?
COLO-678 NUfoNm1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fJdWlEPTB;MkCxMlQ2KM7:TR?= NHvHbWRUSU6JRWK=
NCI-H650 NVzFRolvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJyMj6xNFMh|ryP NWnuNJZIW0GQR1XS
HuCCT1 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrpTJJKSzVyPUKwOE4zODhizszN NGLSeVRUSU6JRWK=
SW1116 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvPTWM2OD1{MEeuNFc4KM7:TR?= MVzTRW5ITVJ?
DBTRG-05MG NV;wU4NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJyNz65NFkh|ryP M2m3fHNCVkeHUh?=
SW982 NH7KN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrMclAzUUN3ME2yNFcvQTR6IN88US=> NWDmWXNxW0GQR1XS
RCM-1 M13DUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG0OIhKSzVyPUKxOE44PjJizszN MWrTRW5ITVJ?
COLO-320-HSR NUnGcoVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJzNj6xNlUh|ryP MkS3V2FPT0WU
KNS-42 MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P1OWlEPTB;MkG2MlU4PCEQvF2= M1XkWXNCVkeHUh?=
C2BBe1 NGnVNpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm5TVVGUUN3ME2yN|EvQTB3IN88US=> NXOzdHRzW0GQR1XS
CCRF-CEM M1z3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ2Mz63PVUh|ryP Ml;EV2FPT0WU
SH-4 NUPlW4liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrLRoVlUUN3ME2yOFYvODlizszN NHv5UoRUSU6JRWK=
LS-1034 M1f5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ2Nj6yOlYh|ryP NITxSlZUSU6JRWK=
NCI-H2347 M3HrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeydJd1UUN3ME2yOFcvPzF|IN88US=> M2r5UHNCVkeHUh?=
RPMI-8866 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7NTWM2OD1{NEmuNlch|ryP NUHzOIljW0GQR1XS
GAK NV\kemhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLwO3dtUUN3ME2yOVMvODB{IN88US=> M3r6WHNCVkeHUh?=
NB6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXHWJRNUUN3ME2yO|AvOSEQvF2= NV\GUJdTW0GQR1XS
COLO-680N MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjPTWM2OD1{N{KuOVI4KM7:TR?= MU\TRW5ITVJ?
RERF-LC-MS NXnZblhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ5Nj6wNFch|ryP NHPV[XBUSU6JRWK=
TGBC11TKB M{L3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ5OD6xO|gh|ryP MkToV2FPT0WU
C8166 NIPRe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\sTWM2OD1{N{iuOVA3KM7:TR?= NVy3S3duW0GQR1XS
HDLM-2 M2n2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ7ND60NFkh|ryP MUfTRW5ITVJ?
IGR-1 M{PNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TX[WlEPTB;Mkm1MlY2QSEQvF2= M4jqcHNCVkeHUh?=
FADU NVHRSI82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L1bGlEPTB;Mkm3MlUyKM7:TR?= NWnDSFVDW0GQR1XS
L-428 M3fI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\ofXBTUUN3ME2yPVcvPjF4IN88US=> M1HRZnNCVkeHUh?=
LU-65 NF3xbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe3T|hDUUN3ME2zNFQvOzJizszN MmDTV2FPT0WU
HEL MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjDUmduUUN3ME2zNFkvQTh|IN88US=> MmfyV2FPT0WU
NCI-H810 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzNfm1KSzVyPUOxNE42PyEQvF2= MWTTRW5ITVJ?
C3A NFzoe2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PDVWlEPTB;M{GxMlgxOiEQvF2= MV3TRW5ITVJ?
NCI-H630 M3vzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN|Mj6yPVQh|ryP NY\ZNIhDW0GQR1XS
KP-N-YN Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDQTWM2OD1|NEGuNVI{KM7:TR?= NGXaOXhUSU6JRWK=
MOLT-13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN2Mj6zNlYh|ryP M3:3OnNCVkeHUh?=
NCI-H1993 MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq2TWM2OD1|NEKuN|Y2KM7:TR?= M{ftcHNCVkeHUh?=
BE-13 NVjnZZAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;KeW5jUUN3ME2zOFQvOTZ5IN88US=> NHHvOYhUSU6JRWK=
IST-SL1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN2Nz60NFEh|ryP NXjDXYVYW0GQR1XS
TE-9 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfsTWM2OD1|NkOuOVg6KM7:TR?= NFXER49USU6JRWK=
LU-135 M2D6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHhfY8{UUN3ME2zOlcvODN3IN88US=> NGnNOFRUSU6JRWK=
T84 M4\FWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C0U2lEPTB;M{e0MlcyOiEQvF2= MWXTRW5ITVJ?
K-562 NVnpOGxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDyUXdUUUN3ME2zPFMvOzZizszN MV\TRW5ITVJ?
SBC-5 M1KzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i0TmlEPTB;M{i2Mlk5PSEQvF2= M3P4fnNCVkeHUh?=
NB17 M2XIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3RTWM2OD1|OUKuOVk3KM7:TR?= MnTaV2FPT0WU
NCI-H2052 M{TMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN7OD60O|Ih|ryP MnO4V2FPT0WU
HCC38 NGfifW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPFTWM2OD12MEGuOVk{KM7:TR?= NVfkSI9XW0GQR1XS
NCI-H69 M2n2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR2MT6wPFMh|ryP MV3TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

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Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

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  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A
Smiles C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID