MK-2206 2HCl

Catalog No.S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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Cited by 682 Publications

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Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)		 Akt2 [1]
(Cell-free assay)		 Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MU\DfZRwfG:6aXOgRZN{[Xl? M4\UPFMh|ryP M3PwU|czKGh? MnrvSG1UVw>? NEXVeo1KdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= Moi0NlA2PzFyNkm=
A431 M320VmtqdmG|ZTDBd5NigQ>? MX21JO69VQ>? NFzq[FI2KGh? MX\EUXNQ MnnqV5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs NUfQ[I9vOjB3N{GwOlk>
HepG2 MYDDfZRwfG:6aXOgRZN{[Xl? NWS3d444OTBizszN MknpNlQhcA>? MYTEUXNQ MlziV4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni M4n4TFIyOjB3OUK1
Sk-Hep1 M3LJ[2N6fG:2b4jpZ{BCe3OjeR?= NIC3OIUyOCEQvF2= NW\QOINWOjRiaB?= M4j6e2ROW09? MXvT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= NXnROGZUOjF{MEW5NlU>
OCUT1 cells harbored PIK3CA (H1047R+/+) MoPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml35N{DPxE1? MljROUBl MnuxSG1UVw>? MnLDTWM2OD1yLkG0JO69VQ>? MYGyNVI5QTJ4Nx?=
K1 cells harbored PIK3CA (E542K+/+) M4\SZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVyzJO69VQ>? NVrlfFZTPSCm MoLZSG1UVw>? NYjUbo9PUUN3ME2wMlUzKM7:TR?= MXKyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) NFW5VZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LVSlMh|ryP NFOyN3I2KGR? NYH0bWNNTE2VTx?= MWLJR|UxRTBwMUig{txO M13Gd|IyOjh7Mk[3
C643 cells harbored HRAS (G13R+/−) NHjKc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTzN{DPxE1? NX;RUmpyPSCm NUXSSJVITE2VTx?= MmXlTWM2OD1yLkK3JO69VQ>? M2Lj[FIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) M3zDfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmzJO69VQ>? MUS1JIQ> NIPyNFdFVVOR NFfpWGhKSzVyPUSuOUDPxE1? MUSyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTHN{DPxE1? Mkm5OUBl M1nQdGROW09? NH24dlZKSzVyPUCuOVkh|ryP MnPGNlEzQDl{Nke=
Hth74 NWj3WllXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUezJO69VQ>? NIHoUWI2KGR? MkjmSG1UVw>? NG\uNXVKSzVyPUKuNVkh|ryP MlHtNlEzQDl{Nke=
KAT18 M2nBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PheFMh|ryP MoH4OUBl NFSxTmVFVVOR MYjJR|UxRTRwNkKg{txO NH7oWpkzOTJ6OUK2Oy=>
SW1736 MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqxNFAh|ryP NFfuW|M2KGR? MljoSG1UVw>? Ml;rTWM2OD12Nz61OkDPxE1? NHzQem0zOTJ6OUK2Oy=>
WRO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfmclMyODByIN88US=> NH\ZUnM2KGR? MoPNSG1UVw>? NFTJe4lKSzVyPkGwNFAh|ryP MX:yNVI5QTJ4Nx?=
TAD2 NUHqXm5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn63NVAxOCEQvF2= NGTGcpA2KGR? NFLnR3JFVVOR NV[2ZWY4UUN3ME6xNFAxKM7:TR?= NUL4[oZWOjF{OEmyOlc>
LN229 Mk\pRZBweHSxc3nzJGF{e2G7 NWDMSow3OC53IN88US=> MVO2NEBp NHWxV2JFVVOR MX3BeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? NYXNXm9ZOjJyNUe5NVQ>
T98G MkfvRZBweHSxc3nzJGF{e2G7 NWC4NJdQOC53IN88US=> Ml25OlAhcA>? NX\4WlQzTE2VTx?= MonURZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? NWHndlltOjJyNUe5NVQ>
HC11 M4rHWGZ2dmO2aX;uJGF{e2G7 NW\tUpdIOTBizszN NXjkbFFVOjRiaB?= NH[2eZFFVVOR NEmwXFBKdmirYnn0d{DPui2lYYPlbY4h[W6mIFHEVnAhe3mwdHjld4l{ NWK0bG8yOjJ2Mk[2NlE>
MOLT-4 MV\DfZRwfG:6aXOgRZN{[Xl? MXWxNEDPxE1? M4POXVQ5KGh? NXznO5FlTE2VTx?= NUnTOFFnUUN3ME2xMlfjiIoQvF2= NXG0dVJDOjJ4MUSyOFM>
CEM-R MXLDfZRwfG:6aXOgRZN{[Xl? NVOwdXd1OTBizszN MkWxOFghcA>? NGDHeI1FVVOR MYDJR|UxRTNwM,MAje69VQ>? NFPn[oszOjZzNEK0Ny=>
CEM-S MXTDfZRwfG:6aXOgRZN{[Xl? M1e0[FExKM7:TR?= MYi0PEBp NXjZfXdsTE2VTx?= MU\JR|UxRTVwMfMAje69VQ>? MY[yNlYyPDJ2Mx?=
MOLT-4 MUTGeY5kfGmxbjDBd5NigQ>? NF\1RlAyOCEQvF2= Mle1NlQhcA>? Ml20SG1UVw>? NGn5cm1DdG:la4OgZ4VtdHNiaX6geIhmKEdyL1exJJBp[XOnIH;mJJRp\SClZXzsJIN6[2yn MX:yNlYyPDJ2Mx?=
MOLT-4 MVfGeY5kfGmxbjDBd5NigQ>? NIXLcWk16oDLzszN NYriNVBoPCCq NUDsVoFkTE2VTx?= MkjpTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{PBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz NXO2SoRVOjJ4MUSyOFM>
CEM-R NIrG[XFHfW6ldHnvckBCe3OjeR?= MVy05qCK|ryP NV3GTYVEPCCq MWTEUXNQ MmqxTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{TBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz MVuyNlYyPDJ2Mx?=
CEM-S M1jlUGZ2dmO2aX;uJGF{e2G7 M4TMc|TjiIoQvF2= MYG0JIg> NVGzeY9vTE2VTx?= MlLxTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{XBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz M37tPVIzPjF2MkSz
HepG2 cell NYPJfYlvU2mwYYPlJGF{e2G7 NHvReYozOCEQvF2= MkjhNlQhcA>? MV\EUXNQ M1zZRmRwf26{ZXf1cIF1\XNidHjlJJBpd3OyaH;yfYxifGmxbjDv[kBCU1R? MYOyN|c6PzNzOR?=
HepG2 cell M{nlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TjVlMxKM7:TR?= Mnj4NlQhcA>? M{nqPWROW09? MnP3TY5pcWKrdIOgZ4VtdCCpcn;3eIg> M4PXbFI{Pzl5M{G5
HepG2 cell NYL1TXRkSXCxcITvd4l{KEG|c3H5 NYfLWY1UOjBizszN Mn\aNlQhcA>? NYTvWVd4TE2VTx?= NX[3UmFOUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= NV2xXGdxOjN5OUezNVk>
GEO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CyVVUxOCCwTR?= Mn;UO|IhcA>? NVrGSJFmTE2VTx?= M37NWmlvcGmkaYTzJINmdGxiZ4Lve5Rp Ml\UNlQ2QDF{M{G=
CNE-1 NYPhd|RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjRNVAh|ryP M4r4W|k3KGh? NX[2XY5OTE2VTx?= NYDVfFlUUUN3ME2yMlk3KM7:TR?= Mk[1NlU{OzZ7MkW=
CNE-2 NXnre2t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXOxNEDPxE1? MojDPVYhcA>? MX\EUXNQ MkXmTWM2OD12LkWzJO69VQ>? MYGyOVM{Pjl{NR?=
HONE-1 NHThfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X3[VExKM7:TR?= MXW5OkBp M4DZXGROW09? MVrJR|UxRTNwM{eg{txO M4Gye|I2OzN4OUK1
SUNE-1 M1rS[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrt[YEyOTBizszN MkjPPVYhcA>? NGr6T3pFVVOR M1XHXmlEPTB;MD61NkDPxE1? M3yyflI2OzN4OUK1
CNE-2 NXPXWoVxTnWwY4Tpc44hSXO|YYm= NWfDeoE4OTBizszN M4\RTlQ5KGh? NHzMR3hFVVOR NIexboVKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz NEDqVoMzPTN|NkmyOS=>
HONE-1 NWP4N5ZVTnWwY4Tpc44hSXO|YYm= NXvIbmpTOTBizszN M1vIXlQ5KGh? NGDIdW9FVVOR MlvDTY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? MYqyOVM{Pjl{NR?=
NEC8 NIPSPJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm3TWM2OD1yLkC5OlUyKM7:TR?= M{\KVXNCVkeHUh?=
P12-ICHIKAWA M1rQ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHXTWM2OD1yLkGxOlIh|ryP M37kcXNCVkeHUh?=
MDA-MB-175-VII M1m1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj4[5pKSzVyPUCuNVM4OzhizszN M4LjXXNCVkeHUh?=
AsPC-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMkKxNlIh|ryP M2PVTnNCVkeHUh?=
T47D NG[wcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW0XJpPUUN3ME2wMlI5OjVizszN MXXTRW5ITVJ?
HH MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwM{CyPFMh|ryP MlXtV2FPT0WU
MOLT-16 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{CzNkDPxE1? NYrNUGJ6W0GQR1XS
ES5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPRTWM2OD1yLkO0OFU2KM7:TR?= Mlu2V2FPT0WU
RS4-11 M{PrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHsV|VWUUN3ME2wMlM1PjFizszN NVvxVXUxW0GQR1XS
KARPAS-45 M3vzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\VTWM2OD1yLkO3N|IyKM7:TR?= MX;TRW5ITVJ?
NCI-H720 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2z[3pLUUN3ME2wMlM4Pjd7IN88US=> NFn5b5BUSU6JRWK=
H9 NWmycW1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTFPGxGUUN3ME2wMlM5QDh|IN88US=> NGfpdVdUSU6JRWK=
EFM-19 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTLTWM2OD1yLkS0NFEh|ryP MnHnV2FPT0WU
SBC-1 NUPnWG97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonZTWM2OD1yLkS0NFM2KM7:TR?= M4P1cHNCVkeHUh?=
A4-Fuk MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zYOmlEPTB;MD60Olg3QCEQvF2= M2nzT3NCVkeHUh?=
NCI-H1563 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLjTWM2OD1yLkS4NVg6KM7:TR?= NYrPbnJ7W0GQR1XS
HCC1419 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\J[GlEPTB;MD60PFg6OiEQvF2= NWK1[Jd7W0GQR1XS
H-EMC-SS NG\zXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jjXmlEPTB;MD60PVk{QSEQvF2= MnXyV2FPT0WU
BHT-101 M13Ue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[3cG5KSzVyPUCuOVI6PjFizszN MkCwV2FPT0WU
IGROV-1 M1;tOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLSNVRCUUN3ME2wMlU2OjR7IN88US=> M3XEVXNCVkeHUh?=
HGC-27 NIj5T5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwNU[3PFMh|ryP MVXTRW5ITVJ?
MDA-MB-361 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNUe3OlEh|ryP MXjTRW5ITVJ?
KE-37 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDZTWM2OD1yLkW4NlYh|ryP NUP1cnNSW0GQR1XS
HCC70 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7IbVRKSzVyPUCuOVk5OjdizszN NUPqNJZRW0GQR1XS
LNCaP-Clone-FGC MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jsZWlEPTB;MD62NVA1QCEQvF2= M{HCSHNCVkeHUh?=
HAL-01 NX2wNmhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK3RW51UUN3ME2wMlYzOTNizszN NFLkSVVUSU6JRWK=
HT MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nHWGlEPTB;MD62N|I{QSEQvF2= MoXBV2FPT0WU
MDA-MB-415 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG0TppKSzVyPUCuOlM3OjZizszN M{XmbHNCVkeHUh?=
NOS-1 NETzS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvjcoFKSzVyPUCuOlM4OjNizszN M3fyR3NCVkeHUh?=
DU-145 NVz5XHdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jjNGlEPTB;MD62OFc1PSEQvF2= NFHhNWFUSU6JRWK=
OCUB-M MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj1TWM2OD1yLkewPVY3KM7:TR?= M3TpW3NCVkeHUh?=
VA-ES-BJ NVjE[ZY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W1b2lEPTB;MD63N|AzPSEQvF2= NGK0NoZUSU6JRWK=
J-RT3-T3-5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HrVGlEPTB;MD63OFQxOyEQvF2= MUPTRW5ITVJ?
MOLT-4 NGTHU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwOEC1PFIh|ryP MlrWV2FPT0WU
NB7 NVi2dmZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXNTldKSzVyPUCuPFI1OTFizszN M4XyZXNCVkeHUh?=
L-363 M4O2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\kfmlEPTB;MD64N|Q1OiEQvF2= NECwSYdUSU6JRWK=
NKM-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jBfmlEPTB;MD64OlI2OyEQvF2= M3jsdXNCVkeHUh?=
HOP-92 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfzTWM2OD1yLki3NlI{KM7:TR?= MVTTRW5ITVJ?
OAW-42 NEPVd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwOEi3NkDPxE1? NET0[5lUSU6JRWK=
HuO9 M4D1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULNOFZnUUN3ME2wMlkzPzVzIN88US=> NIfTTnVUSU6JRWK=
MFE-280 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfDTJlKSzVyPUCuPVY1PjVizszN MojMV2FPT0WU
EM-2 NHPVWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwOUe5N|kh|ryP MlLmV2FPT0WU
NCI-H520 M1;VWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILXUXlKSzVyPUCuPVg2QTJizszN NFXvPVFUSU6JRWK=
LB2241-RCC NGrTOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwOUm3N|Qh|ryP NYXucYxCW0GQR1XS
SK-NEP-1 M13sbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X1bmlEPTB;MT6xOFQ5PSEQvF2= NELNWWhUSU6JRWK=
LXF-289 NFv3T5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjpbVRvUUN3ME2xMlE4OTV4IN88US=> NGf0dGVUSU6JRWK=
EPLC-272H NULC[Xp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv5TWM2OD1zLkG3NlU3KM7:TR?= MUHTRW5ITVJ?
COLO-684 M{LxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfSenJYUUN3ME2xMlI{PzJ3IN88US=> NXrKV2ZJW0GQR1XS
ES1 M{fNR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKyXW9jUUN3ME2xMlI1ODZ3IN88US=> Mmn0V2FPT0WU
DOHH-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwMkiyNFMh|ryP Mnz3V2FPT0WU
CTB-1 NIjJXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7NT5ZKSzVyPUGuNlg6QSEQvF2= NE[yPHpUSU6JRWK=
G-401 NFrCbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDXTVlKSzVyPUGuNlk4QTVizszN NIX3V3lUSU6JRWK=
LoVo M3u1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PnSGlEPTB;MT6zNlU{PCEQvF2= NGPNSW5USU6JRWK=
Ramos-2G6-4C10 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7QTWM2OD1zLkOzO|AyKM7:TR?= NWLCfJRZW0GQR1XS
MFM-223 M3G5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXj[HpKSzVyPUGuN|Q1PjFizszN Mn62V2FPT0WU
PA-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rkXWlEPTB;MT6zOVI3PSEQvF2= Mnr3V2FPT0WU
697 NFnze4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTtcJNUUUN3ME2xMlM4PjF4IN88US=> MUjTRW5ITVJ?
QIMR-WIL NH62XpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjEOZVKSzVyPUGuOFkyOTZizszN NU[3PXhuW0GQR1XS
HOS Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwNEm1OVgh|ryP MUPTRW5ITVJ?
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SF126 NE\oOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:wdmxKSzVyPUiuOFU6OzZizszN MkLLV2FPT0WU
LB996-RCC MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjMe29KSzVyPUiuOVMzPTdizszN MXrTRW5ITVJ?
SKG-IIIa MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvPeotPUUN3ME24MlY{ODZ7IN88US=> M2\NO3NCVkeHUh?=
NCI-SNU-1 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRThwNkS2OFMh|ryP NIHSWI9USU6JRWK=
LB771-HNC NFLpeZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fYWGlEPTB;OD62OFY6PiEQvF2= NFjXNZRUSU6JRWK=
SCC-4 NEixRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfn[45KSzVyPUiuOlgzOTlizszN MVfTRW5ITVJ?
CAMA-1 NIfBTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHuTWM2OD16Lke3NVQ3KM7:TR?= NFLWcpVUSU6JRWK=
D-502MG MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPXfHBGUUN3ME24Mlc5PjJ7IN88US=> NGD3TIxUSU6JRWK=
ESS-1 M{HQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPrTWM2OD16Lki4O|A1KM7:TR?= MVnTRW5ITVJ?
HEC-1 M1Pvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHPZYRKSzVyPUiuPFk5PjZizszN M{GxRnNCVkeHUh?=
NB10 NHnYTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTNPXhDUUN3ME25MlAzOjJ2IN88US=> NFWx[lZUSU6JRWK=
8505C M2rxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvOdlhQUUN3ME25MlA1OjN{IN88US=> NWrBTZRVW0GQR1XS
EFO-27 M4DESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwMU[0NVIh|ryP MWXTRW5ITVJ?
HN MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HGOGlEPTB;OT6xOlYzQCEQvF2= NWjnTHg5W0GQR1XS
DSH1 NHLRPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjSTFA3UUN3ME25MlIxQDdizszN NGjiWmVUSU6JRWK=
NBsusSR NX\pWm5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXWOW8xUUN3ME25MlI4PDB{IN88US=> M1WyTXNCVkeHUh?=
LS-123 M2rBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;zc2lEPTB;OT6zNVc3OSEQvF2= MYLTRW5ITVJ?
SHP-77 NGXK[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rMPGlEPTB;OT6zPVk{PSEQvF2= MVnTRW5ITVJ?
ACN NWT2co13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\LRWlEPTB;OT61N|I4PyEQvF2= NV;UNmg6W0GQR1XS
U251 NYn1UXU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT0TWM2OD17Lk[1OVQ1KM7:TR?= NXP1coNlW0GQR1XS
A431 NFnTZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTlwOECyN|gh|ryP MnuxV2FPT0WU
5637 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjwVoRKSzVyPUmuPFQ6QDRizszN M{jqSHNCVkeHUh?=
MDA-MB-157 NEDVb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fG[mlEPTB;OT65Nlg4QCEQvF2= NWXvXoRrW0GQR1XS
A101D NHjMdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTlwOUm5O|Qh|ryP M{XwXXNCVkeHUh?=
YKG-1 NYm4cId7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFyLkKwNFYh|ryP M1fXXnNCVkeHUh?=
LAN-6 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v2XGlEPTB;MUCuNlE3PCEQvF2= M{jJenNCVkeHUh?=
OVCAR-5 NWGzepBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFyLkK0N|Mh|ryP NFXib|RUSU6JRWK=
A549 NHXoOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLRTWM2OD1zMD6zPVc{KM7:TR?= MWrTRW5ITVJ?
no-11 NXK3N5RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTPTWM2OD1zMD60N|U{KM7:TR?= NI[wUGRUSU6JRWK=
SF539 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi0fIpWUUN3ME2xNE46ODRzIN88US=> M17UcHNCVkeHUh?=
A388 NGfLSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLpOlE5UUN3ME2xNU4{QDl5IN88US=> NHzQOoVUSU6JRWK=
DEL M2P0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrBemZoUUN3ME2xNU41OjRizszN MXLTRW5ITVJ?
SW954 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrndZFNUUN3ME2xNU41PjZ6IN88US=> M1rSfXNCVkeHUh?=
TK10 M32xOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXiS3p5UUN3ME2xNU42OjdzIN88US=> Mo\5V2FPT0WU
SW756 NGDmfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TUO2lEPTB;MUGuOVI6PCEQvF2= NH;vcIpUSU6JRWK=
PC-3 M2PZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rCS2lEPTB;MUGuOVc3PCEQvF2= NHzzXGJUSU6JRWK=
ONS-76 MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnXWpV5UUN3ME2xNU43OzZizszN MlLqV2FPT0WU
A427 MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHjS4Y2UUN3ME2xNU44ODl|IN88US=> NFzVS4RUSU6JRWK=
MEG-01 NH3JO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PNe2lEPTB;MUGuO|UxQSEQvF2= NGnhOFZUSU6JRWK=
BB30-HNC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPXcI5KSzVyPUGxMlc6QDJizszN NH\ycGdUSU6JRWK=
NCI-H1299 NWP6RYZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n0S2lEPTB;MUGuPFA6OyEQvF2= M3nPSnNCVkeHUh?=
GCT NYCwe4ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFzLkiyNlgh|ryP MkHFV2FPT0WU
D-247MG M{LJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHKTWM2OD1zMT65OlY{KM7:TR?= MWXTRW5ITVJ?
CFPAC-1 NVzicoZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFzLkm3PFIh|ryP MomyV2FPT0WU
EKVX NIexZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj4Z4k4UUN3ME2xNk4xOzF|IN88US=> MlXsV2FPT0WU
CAL-51 M3nkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\TTWM2OD1zMj6wO|E3KM7:TR?= NUjsZlk1W0GQR1XS
BB49-HNC NXLxXlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XYXWlEPTB;MUKuNVE4PyEQvF2= Mlz1V2FPT0WU
RPMI-7951 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rYUGlEPTB;MUKuNVg2PCEQvF2= NXfSbW1vW0GQR1XS
RH-1 NIqwXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELqXFZKSzVyPUGyMlIyQDRizszN NF;XSHBUSU6JRWK=
BCPAP MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r3dWlEPTB;MUKuOFc1QSEQvF2= NXfPSIlnW0GQR1XS
GCIY NX;yZot2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF{LkWyNFkh|ryP MkniV2FPT0WU
KNS-81-FD MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HENWlEPTB;MUKuOVg3QSEQvF2= MVLTRW5ITVJ?
KYSE-140 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LxeWlEPTB;MUKuPFU6PSEQvF2= M2n0XXNCVkeHUh?=
Ca-Ski NHrIdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPtXmxKSzVyPUGyMlkxPDFizszN M2TnXXNCVkeHUh?=
TGBC1TKB NFvrZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDVT|ZKSzVyPUGyMlkyOTVizszN NF3SUlZUSU6JRWK=
HCC1187 NFHCblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFztS2lKSzVyPUGzMlE6OTJizszN MVLTRW5ITVJ?
SJSA-1 M3nGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TaT2lEPTB;MUOuNlMzPyEQvF2= M2jCTHNCVkeHUh?=
CTV-1 NUPDV2hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jWVmlEPTB;MUOuN|Q2KM7:TR?= NH\aWGlUSU6JRWK=
WM-115 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXo[pBKSzVyPUGzMlY1QDNizszN MliwV2FPT0WU
CHP-212 NHrFSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M331W2lEPTB;MUOuPVc{QSEQvF2= MmPHV2FPT0WU
SCC-15 M1TFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4naW2lEPTB;MUOuPVc4PSEQvF2= MYrTRW5ITVJ?
BPH-1 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF2LkG2OlQh|ryP M2fLd3NCVkeHUh?=
SW780 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTF2LkWwNlUh|ryP MU\TRW5ITVJ?
NCI-H2291 NVX3bllsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7NTWM2OD1zND61PFc5KM7:TR?= NFHPc2FUSU6JRWK=
JEG-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPqUlFKSzVyPUG0MlY{OjZizszN MkTzV2FPT0WU
CAL-120 M1rlOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELKV|VKSzVyPUG0MlcxOjdizszN NWnRW4prW0GQR1XS
NCI-H23 NWfpU2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m4eWlEPTB;MUSuO|k6PyEQvF2= NHTLbVhUSU6JRWK=
MS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvmU4pKSzVyPUG0Mlk3OTFizszN NULSb|YyW0GQR1XS
PC-14 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrVTWM2OD1zND65OlU1KM7:TR?= MkHsV2FPT0WU
D-283MED NIfRU4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF3LkCxNVEh|ryP NX3IWHdOW0GQR1XS
OE19 NH;KW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OwbWlEPTB;MUWuNVU1OSEQvF2= MVLTRW5ITVJ?
CAS-1 NHq3WIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonvTWM2OD1zNT60NVg1KM7:TR?= Mly4V2FPT0WU
NCI-H727 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDFTWM2OD1zNT60NlIyKM7:TR?= Moe3V2FPT0WU
SiHa MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjKTWM2OD1zNT63OVk1KM7:TR?= M{DSb3NCVkeHUh?=
BFTC-905 NYfV[VJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[wfXZKSzVyPUG1Mlc3QTRizszN NXTabHB2W0GQR1XS
MDA-MB-453 NFvC[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\RTGlEPTB;MU[uNVY1OiEQvF2= MXnTRW5ITVJ?
HuP-T3 M{flcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rJVGlEPTB;MU[uOlM4OyEQvF2= NFr0UZRUSU6JRWK=
SK-LU-1 NFH2W4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF4Lk[5OVYh|ryP MYjTRW5ITVJ?
Detroit562 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjKOYRKSzVyPUG2Mlc{OThizszN NV\vOGZwW0GQR1XS
HCC1569 NGOwTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3LTWM2OD1zNj64N|M4KM7:TR?= MVvTRW5ITVJ?
SK-MES-1 M{fVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF4Lki0NVkh|ryP NGHUPHhUSU6JRWK=
BB65-RCC NIn3e3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXJTWM2OD1zNz6wOFc6KM7:TR?= NYO4eHVIW0GQR1XS
LOXIMVI MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHhTWM2OD1zNz6wO|A4KM7:TR?= MlztV2FPT0WU
SW1783 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW3cXVKSzVyPUG3MlEzQCEQvF2= NVj6VGs5W0GQR1XS
NH-12 NIXxUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTwTWM2OD1zNz6zN|A{KM7:TR?= NUjFSmE{W0GQR1XS
UACC-257 NHvteXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfVT2dmUUN3ME2xO{42PTF{IN88US=> MV3TRW5ITVJ?
KOSC-2 M3:2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLtUYRKSzVyPUG3MlY4PTdizszN NFG3bplUSU6JRWK=
KG-1 NIDq[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKzTWM2OD1zNz62PVM4KM7:TR?= M3PFdnNCVkeHUh?=
M059J M2jsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LJRmlEPTB;MUeuO|A{KM7:TR?= MVjTRW5ITVJ?
MHH-NB-11 NHLISWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi3SoRKUUN3ME2xO{46Pjd|IN88US=> NYHoO4RXW0GQR1XS
EW-1 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHLTWM2OD1zOD6xN|gzKM7:TR?= NV\pNmJsW0GQR1XS
CAL-85-1 NFvSUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULkSItxUUN3ME2xPE4zOzV5IN88US=> M3e2OnNCVkeHUh?=
639-V MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETveZZKSzVyPUG4MlM{PTRizszN NF2xclFUSU6JRWK=
C32 NXTWd5loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnrOIFKSzVyPUG4MlQ4OjdizszN NFP1PYFUSU6JRWK=
KM-H2 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF6LkWyN|Ih|ryP MWrTRW5ITVJ?
A253 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ETWM2OD1zOD63Nlg3KM7:TR?= MWnTRW5ITVJ?
NCI-N87 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTRS3lvUUN3ME2xPE46ODB6IN88US=> MV7TRW5ITVJ?
8-MG-BA NYfU[WFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;RTWM2OD1zOT6wOlQ3KM7:TR?= M2n2cnNCVkeHUh?=
GI-ME-N NYnDNodyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP6XHFqUUN3ME2xPU4yPTR4IN88US=> NEXLO3NUSU6JRWK=
8305C M2XUfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHkNYZQUUN3ME2xPU4zOjh4IN88US=> Mm\YV2FPT0WU
TE-8 NGrURlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvEOlF4UUN3ME2xPU4{ODJ2IN88US=> NXG2[HpqW0GQR1XS
KYSE-270 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13Dd2lEPTB;MkCuNFIyPyEQvF2= NX75OIdUW0GQR1XS
HL-60 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\mWZo6UUN3ME2yNE4xQTRzIN88US=> NUPmeYlzW0GQR1XS
Mo-T M2n2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LNSmlEPTB;MkCuNVY3PSEQvF2= M{DwbXNCVkeHUh?=
NCI-H1355 M4[3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfoRlRKSzVyPUKwMlM{PzRizszN MUPTRW5ITVJ?
HT-1080 M1j1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r4[2lEPTB;MkCuOVQ6PyEQvF2= M3PFVHNCVkeHUh?=
MIA-PaCa-2 M3fyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJyLk[4PFMh|ryP Ml\jV2FPT0WU
NCI-H441 M1XaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv1ZZJKSzVyPUKwMlc{PzlizszN NUXxcJJPW0GQR1XS
LCLC-97TM1 NEjRbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrOSmdvUUN3ME2yNE45OTN2IN88US=> NHfISZdUSU6JRWK=
HT-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJzLkW2N|Eh|ryP MoPSV2FPT0WU
22RV1 NXj5bmYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\aTWM2OD1{MT61Olg2KM7:TR?= NGfSOZlUSU6JRWK=
LK-2 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJzLkW5OVMh|ryP NHL4PWVUSU6JRWK=
CW-2 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\iTWM2OD1{MT62NFY6KM7:TR?= MofjV2FPT0WU
KYSE-510 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vob2lEPTB;MkGuOlA6PSEQvF2= MYHTRW5ITVJ?
CGTH-W-1 NVTuW2pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzUmlEPTB;MkGuO|E3PiEQvF2= NUTJZllsW0GQR1XS
NCI-H661 NInsOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HQNWlEPTB;MkKuNFM1KM7:TR?= M176NXNCVkeHUh?=
KU-19-19 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\vXYxKSzVyPUKyMlE3QTdizszN MkX3V2FPT0WU
NCI-H2122 NWL0TYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ{LkK0N|Ih|ryP NEnETppUSU6JRWK=
NCI-H526 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLtdmVKSzVyPUKyMlM5QTVizszN Ml[wV2FPT0WU
NCI-H1650 NYnCNHlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLWVldRUUN3ME2yNk44PjRizszN NELqZW1USU6JRWK=
AM-38 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S4TWlEPTB;MkKuPFY5QSEQvF2= MVrTRW5ITVJ?
NCI-H2405 M17IRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e1bGlEPTB;MkOuNlU{OyEQvF2= M3HCZXNCVkeHUh?=
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KY821 Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\Mb4xXUUN3ME24OE4xQDl{IN88US=> M3XQbnNCVkeHUh?=
DoTc2-4510 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDqTWM2OD16ND6yNVg2KM7:TR?= NGrLVoZUSU6JRWK=
NCI-H1581 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfaTHk1UUN3ME24OU41PjRzIN88US=> NEDPOXVUSU6JRWK=
KARPAS-299 M4PXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\kZ2lEPTB;OE[uNVk4PyEQvF2= M3jX[XNCVkeHUh?=
IST-MEL1 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f0bGlEPTB;OE[uPFg4OiEQvF2= NXXye3NJW0GQR1XS
KP-N-YS NH75[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTh7LkmwNlgh|ryP M4HCU3NCVkeHUh?=
KYSE-410 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG1XmRCUUN3ME25NU41ODR{IN88US=> MYLTRW5ITVJ?
TE-10 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MleyTWM2OD17MT61OlEyKM7:TR?= MknWV2FPT0WU
SK-MEL-1 MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTBfIlKSzVyPUmyMlkyODZizszN NESycWhUSU6JRWK=
COLO-792 NI[0XlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTl3LkK1OlQh|ryP NE\Mc4xUSU6JRWK=
SCH MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjYTWM2OD17Nj6zPFc4KM7:TR?= NVPsOHZ7W0GQR1XS
NCI-H1792 NHHqV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTl4Lki5PVIh|ryP NUPtXYl{W0GQR1XS
NCI-H2029 M3PBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTl4Lkm1OlYh|ryP M2H1[3NCVkeHUh?=
SW684 NHrpcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm1TWM2OD17OD62OlU1KM7:TR?= M3HpUnNCVkeHUh?=
NCI-H209 NX7ZeVl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjNZ5dKSzVyPUGwNE4yOjFizszN NILh[pZUSU6JRWK=
HLE NXq3PJRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFyNT6yPFIh|ryP M4r3T3NCVkeHUh?=
GOTO MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r3N2lEPTB;MUC3Mlc4PyEQvF2= MnjDV2FPT0WU
NCI-H1793 NULVeo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DUUmlEPTB;MUC5MlI5KM7:TR?= NVrWTVhRW0GQR1XS
D-392MG NYnwTFNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;NeYNKSzVyPUGxO{4{QThizszN M{O2TnNCVkeHUh?=
SW1990 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDtTWM2OD1zMkCuPVUyKM7:TR?= MlfFV2FPT0WU
ML-2 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF{MT62O|Yh|ryP Ml:3V2FPT0WU
NCI-H2452 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLxTWM2OD1zMkKuNlEh|ryP MWTTRW5ITVJ?
SK-MEL-30 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjRPHc6UUN3ME2xNlMvOjR2IN88US=> M4DsOHNCVkeHUh?=
SN12C MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPxT45KSzVyPUGyOE4yPzZizszN NUK1fHJOW0GQR1XS
NCI-H1770 NYPuclJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF{NT61NVQh|ryP M16wdnNCVkeHUh?=
SF268 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Ll[WlEPTB;MUK2MlE2QCEQvF2= NI\DVVJUSU6JRWK=
BALL-1 NGfzVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle0TWM2OD1zMk[uNlMh|ryP Mnq2V2FPT0WU
COLO-679 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF{Nj63OVMh|ryP NETLWGlUSU6JRWK=
A2780 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTF{OD65PFgh|ryP NVnQc4V4W0GQR1XS
NCI-H1651 NYXoWZN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTsUGNrUUN3ME2xN|EvOjR|IN88US=> MlTnV2FPT0WU
NCI-H2087 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjEfGI{UUN3ME2xN|EvPDh|IN88US=> M1zjeXNCVkeHUh?=
U-87-MG M1HE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETuRnpKSzVyPUGzN{43ODRizszN MW\TRW5ITVJ?
LB2518-MEL NHLy[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3HUFJ4UUN3ME2xN|UvQTl|IN88US=> MkTpV2FPT0WU
HCT-116 NGfudIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LDdGlEPTB;MUO3MlIyPyEQvF2= Mn;KV2FPT0WU
Ca9-22 NFS1PW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknjTWM2OD1zM{muPFM{KM7:TR?= NIHOXYNUSU6JRWK=
COR-L88 NWjWR3VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LQTWlEPTB;MUSyMlE1KM7:TR?= NH6zW2ZUSU6JRWK=
CP50-MEL-B MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nPbWlEPTB;MUS0MlUxOSEQvF2= MlfiV2FPT0WU
OVCAR-8 M3rybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuzXnlXUUN3ME2xOFUvPjN4IN88US=> MlOwV2FPT0WU
SK-MEL-3 NFXRb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInOVIlKSzVyPUG0O{45PzhizszN MXfTRW5ITVJ?
GT3TKB NHHZbmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;PTWM2OD1zNEmuPVI5KM7:TR?= MUjTRW5ITVJ?
KYSE-450 NVLFdmxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF3MT61N|kh|ryP NV75ZYxLW0GQR1XS
CAPAN-1 M3L0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUftdHRPUUN3ME2xOVMvODZ2IN88US=> NELiTIhUSU6JRWK=
BEN M2KxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS1eWhKUUN3ME2xOVMvQTJ6IN88US=> Ml\6V2FPT0WU
NCI-H1304 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF3ND62PVQh|ryP NGPB[ZNUSU6JRWK=
KU812 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ycmlEPTB;MUW4MlY4PCEQvF2= NYDDWHdwW0GQR1XS
Capan-2 M3rudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTF4MD61OVMh|ryP NUHUdGROW0GQR1XS
A673 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW0TWM2OD1zNkGuO|A2KM7:TR?= MXLTRW5ITVJ?
SAS M{DGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrDVIM4UUN3ME2xOlIvPjd6IN88US=> MU\TRW5ITVJ?
NY MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF4NT6zNVQh|ryP M2SzdXNCVkeHUh?=
HCE-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjWTWM2OD1zNk[uPFQ2KM7:TR?= M{CwWXNCVkeHUh?=
MDA-MB-231 M2PlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTzc4RKSzVyPUG3O{42ODNizszN Mn:0V2FPT0WU
no-10 M17BZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ZTWM2OD1zN{iuNVM1KM7:TR?= NHjBeVZUSU6JRWK=
MZ7-mel NUTzZpF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTF5OD60Olch|ryP MoWwV2FPT0WU
NCI-H82 NYi4RXZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF6MD6xOlUh|ryP NXHrb5B[W0GQR1XS
CAL-72 MlHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvaOIZKSzVyPUG4OU4xPTRizszN NXjnOWFEW0GQR1XS
NCI-SNU-5 NEnlO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfteXIxUUN3ME2xPFYvQDRizszN M1e3NHNCVkeHUh?=
OVCAR-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULXc5VEUUN3ME2xPFgvOzN|IN88US=> M2jrb3NCVkeHUh?=
SCC-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF7MTFOwG0> NI\EdmhUSU6JRWK=
KYSE-150 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojRTWM2OD1zOUGuPFg5KM7:TR?= NV7jO3dEW0GQR1XS
HT-29 NUDEZ4s3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJyMT6yNVIh|ryP MmLkV2FPT0WU
COLO-678 NIrHcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPCTWM2OD1{MEGuOFUh|ryP MlnDV2FPT0WU
NCI-H650 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW4TWM2OD1{MEKuNVA{KM7:TR?= MmrZV2FPT0WU
HuCCT1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fNNWlEPTB;MkC0MlIxQCEQvF2= M1n3V3NCVkeHUh?=
SW1116 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:zVmlEPTB;MkC3MlA4PyEQvF2= NEG5b4hUSU6JRWK=
DBTRG-05MG NITYcJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJyNz65NFkh|ryP NUnr[lJZW0GQR1XS
SW982 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjMT2xMUUN3ME2yNFcvQTR6IN88US=> NFnNNmRUSU6JRWK=
RCM-1 MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\RTWM2OD1{MUSuO|YzKM7:TR?= M{XucXNCVkeHUh?=
COLO-320-HSR M2WzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJzNj6xNlUh|ryP M{XMOHNCVkeHUh?=
KNS-42 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfDRZdKSzVyPUKxOk42PzRizszN MX3TRW5ITVJ?
C2BBe1 NVzFdmRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\lNoFkUUN3ME2yN|EvQTB3IN88US=> NWDndpFmW0GQR1XS
CCRF-CEM NUDtcnJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJ2Mz63PVUh|ryP MlnrV2FPT0WU
SH-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLEeoVKSzVyPUK0Ok4xQSEQvF2= MVnTRW5ITVJ?
LS-1034 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ2Nj6yOlYh|ryP NYfTdIVFW0GQR1XS
NCI-H2347 NIWwfllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj3TWM2OD1{NEeuO|E{KM7:TR?= NYrlRmtuW0GQR1XS
RPMI-8866 NGHTcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGzeFJKSzVyPUK0PU4zPyEQvF2= NVfzTnBiW0GQR1XS
GAK NGO4[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;nUVFKSzVyPUK1N{4xODJizszN NH7PNYxUSU6JRWK=
NB6 NHzHfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDSW9XUUN3ME2yO|AvOSEQvF2= MmT1V2FPT0WU
COLO-680N NXvl[Gd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXPTWM2OD1{N{KuOVI4KM7:TR?= MYrTRW5ITVJ?
RERF-LC-MS M4\4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL4WGFzUUN3ME2yO|YvODB5IN88US=> MWDTRW5ITVJ?
TGBC11TKB NFnQVWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJ5OD6xO|gh|ryP MWLTRW5ITVJ?
C8166 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC4UFhKSzVyPUK3PE42ODZizszN M1vjVXNCVkeHUh?=
HDLM-2 NWXSSZZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PB[2lEPTB;Mkm0MlQxQSEQvF2= M3zzZXNCVkeHUh?=
IGR-1 NFLoU4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnviTWM2OD1{OUWuOlU6KM7:TR?= Mny2V2FPT0WU
FADU M1zKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ7Nz61NUDPxE1? M3rhRXNCVkeHUh?=
L-428 NETCUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e1dmlEPTB;Mkm3MlYyPiEQvF2= MWnTRW5ITVJ?
LU-65 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLmSJlKSzVyPUOwOE4{OiEQvF2= MXTTRW5ITVJ?
HEL NUHh[2toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjtXXRDUUN3ME2zNFkvQTh|IN88US=> NFP5OlJUSU6JRWK=
NCI-H810 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV33NpdTUUN3ME2zNVAvPTdizszN NXPIV403W0GQR1XS
C3A NYe2eWNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPUPYtKSzVyPUOxNU45ODJizszN NV3LZWU4W0GQR1XS
NCI-H630 M3rnbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;yXWlEPTB;M{OyMlI6PCEQvF2= MmO4V2FPT0WU
KP-N-YN M3q0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP2R3FDUUN3ME2zOFEvOTJ|IN88US=> MWDTRW5ITVJ?
MOLT-13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OwS2lEPTB;M{SyMlMzPiEQvF2= M4TJ[HNCVkeHUh?=
NCI-H1993 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN2Mj6zOlUh|ryP MoT2V2FPT0WU
BE-13 NGiwdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TjdmlEPTB;M{S0MlE3PyEQvF2= NXvUbGl3W0GQR1XS
IST-SL1 NHvlb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTN2Nz60NFEh|ryP NHzOc5NUSU6JRWK=
TE-9 NVTIZmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTN4Mz61PFkh|ryP M4q0VXNCVkeHUh?=
LU-135 NGT4U5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPFVVN1UUN3ME2zOlcvODN3IN88US=> MVTTRW5ITVJ?
T84 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN5ND63NVIh|ryP M{G0VnNCVkeHUh?=
K-562 NX:5WoV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXkXGJKSzVyPUO4N{4{PiEQvF2= NYKybm9EW0GQR1XS
SBC-5 M3L4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDkV2JGUUN3ME2zPFYvQTh3IN88US=> NUHHZplkW0GQR1XS
NB17 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jTVmlEPTB;M{myMlU6PiEQvF2= NFvuVJRUSU6JRWK=
NCI-H2052 MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2OwVWlEPTB;M{m4MlQ4OiEQvF2= M3K5fHNCVkeHUh?=
HCC38 M4nDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ORYhUUUN3ME20NFEvPTl|IN88US=> NEDiRpFUSU6JRWK=
NCI-H69 NHXOcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO3eoVKSzVyPUS0NU4xQDNizszN M4TsfXNCVkeHUh?=

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]
+ Expand

Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]
+ Expand
  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]
+ Expand
  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Formulation: Formulated in 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing. 		17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl
CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

selleck catalog

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

  • Selective Akt Inhibitor

    CCT128930 : AKT2-selective, IC50=6 nM.

  • Most Potent Akt Inhibitor

    AZD5363 : Akt1, IC50=3 nM; Akt2, IC50=8 nM; Akt3, IC50=8 nM.

  • Akt Inhibitor in Clinical Trial

    Perifosine (KRX-0401) : Phase III fro relapsed and refractory multiple myeloma.

  • Newest Akt Inhibitor

    AZD5363 : Potent inhibitor of all isoforms of Akt (Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM, similar to P70S6K/PKA and lower activity towards ROCK1/2.

Related Akt Products

  • Afuresertib (GSK2110183) New

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • AT13148 New

    AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

  • SC79 New

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

  • Capivasertib (AZD5363)

    AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • Ipatasertib (GDC-0068)

    Ipatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.

  • GSK690693

    GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

  • A-674563

    A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.

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  • Honokiol

    Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID