MK-2206 2HCl

For research use only.

Catalog No.S1078

1442 publications

MK-2206 2HCl Chemical Structure

CAS No. 1032350-13-2

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.

Selleck's MK-2206 2HCl has been cited by 1442 publications

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H69 NYjveIR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTR2MT6wPFMh|ryP M3TkVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
HCC38 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\1T2txUUN3ME20NFEvPTl|IN88US=> M1PIVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H2052 NHPvO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTN7OD60O|Ih|ryP NXPV[FhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
NB17 NXjEV3VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPXbnNYUUN3ME2zPVIvPTl4IN88US=> NUjlUoFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
SBC-5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly1TWM2OD1|OE[uPVg2KM7:TR?= NULqOZRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
K-562 NWnqcVBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPIWHRKSzVyPUO4N{4{PiEQvF2= NXjwdZZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
T84 NY\tOWRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDy[YxnUUN3ME2zO|QvPzF{IN88US=> M33C[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
LU-135 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XTdGlEPTB;M{[3MlA{PSEQvF2= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
TE-9 M{GzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmzZXp6UUN3ME2zOlMvPTh7IN88US=> NFm4UIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
IST-SL1 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEntSZVKSzVyPUO0O{41ODFizszN M4W1TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
BE-13 NVz4dXB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj1UWJ4UUN3ME2zOFQvOTZ5IN88US=> M{PTSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H1993 NHzQe5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTN2Mj6zOlUh|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
MOLT-13 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN2Mj6zNlYh|ryP M3WzXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H630 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT1Tnk4UUN3ME2zN|IvOjl2IN88US=> NG\RVZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
KP-N-YN NVf0TFBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnz[FNrUUN3ME2zOFEvOTJ|IN88US=> MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
C3A NWXl[2ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIiySnRKSzVyPUOxNU45ODJizszN NXrFSGJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
HEL MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfnW256UUN3ME2zNFkvQTh|IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
NCI-H810 NVPrU3VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljQTWM2OD1|MUCuOVch|ryP MlPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
LU-65 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL6[m9FUUN3ME2zNFQvOzJizszN NWnCfXBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
L-428 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfLZmpIUUN3ME2yPVcvPjF4IN88US=> MnXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
FADU MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ZO29KSzVyPUK5O{42OSEQvF2= M1fXUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
IGR-1 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ7NT62OVkh|ryP M1\Y[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
HDLM-2 M{\X[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjwRYZKSzVyPUK5OE41ODlizszN NVjPeVRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
C8166 NH;hXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nvNGlEPTB;Mke4MlUxPiEQvF2= M3i2XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
TGBC11TKB NVOzVFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi2cXNJUUN3ME2yO|gvOTd6IN88US=> M1jMbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
RERF-LC-MS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ5Nj6wNFch|ryP MmL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
COLO-680N NEj0TnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HvbmlEPTB;MkeyMlUzPyEQvF2= NV;vfHlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
NB6 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULxcmg2UUN3ME2yO|AvOSEQvF2= M4O2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
GAK NIDmPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy4TJFtUUN3ME2yOVMvODB{IN88US=> MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
RPMI-8866 M{jtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zzbmlEPTB;MkS5MlI4KM7:TR?= M3nwWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H2347 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjVTWM2OD1{NEeuO|E{KM7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
LS-1034 NWP5T4RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXhTWM2OD1{NE[uNlY3KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
SH-4 NYG4RXZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLreXJKSzVyPUK0Ok4xQSEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
CCRF-CEM Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ybGlEPTB;MkSzMlc6PSEQvF2= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
C2BBe1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq2TWM2OD1{M{GuPVA2KM7:TR?= MnrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
COLO-320-HSR Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu4TWM2OD1{MU[uNVI2KM7:TR?= NEnuXmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
KNS-42 NYXU[XVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD3TWM2OD1{MU[uOVc1KM7:TR?= Moi5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
RCM-1 NUjyXoZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJzND63OlIh|ryP NE\CW409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
DBTRG-05MG NVPqWpR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTHTWM2OD1{MEeuPVA6KM7:TR?= MnL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
SW982 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJyNz65OFgh|ryP M{jsR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
SW1116 M17ZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3VGVDUUN3ME2yNFcvODd5IN88US=> MlrQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
HuCCT1 MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr3OWNJUUN3ME2yNFQvOjB6IN88US=> M2\R[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H650 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT4emFKSzVyPUKwNk4yODNizszN MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
COLO-678 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnwN4FKSzVyPUKwNU41PSEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
HT-29 NWTI[JpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJyMT6yNVIh|ryP Ml\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
SCC-9 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PEPWlEPTB;MUmxJO69VQ>? NIftUFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
KYSE-150 NGT0eXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDDfY1LUUN3ME2xPVEvQDh6IN88US=> MnjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
OVCAR-4 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\oTWM2OD1zOEiuN|M{KM7:TR?= M{nwVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-SNU-5 NFe5ZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF6Nj64OEDPxE1? NF2wTpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
CAL-72 NF7mWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7NR|ZKSzVyPUG4OU4xPTRizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
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MZ7-mel NH;DbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;wS2ZKSzVyPUG3PE41PjdizszN NH\0VFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
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MDA-MB-231 NID4b|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF5Nz61NFMh|ryP M4\ZeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
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NY NVfId|ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\BVFRKSzVyPUG2OU4{OTRizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
A673 NHqxRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTF4MT63NFUh|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
SAS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrxZZhKSzVyPUG2Nk43PzhizszN NYKyS|J5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
Capan-2 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXnSG9KSzVyPUG2NE42PTNizszN MmTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
KU812 NFTuO|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nTOGlEPTB;MUW4MlY4PCEQvF2= NFfwN|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
NCI-H1304 NGWycYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF3ND62PVQh|ryP NGjp[4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
CAPAN-1 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF3Mz6wOlQh|ryP NVX1RXhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
BEN NV;xe|IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3hcWpKSzVyPUG1N{46OjhizszN Mn;sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
KYSE-450 NYTLN21LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF3MT61N|kh|ryP NWLzbHRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
GT3TKB MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrqTWM2OD1zNEmuPVI5KM7:TR?= NWjsVpczRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
SK-MEL-3 NXPqOJh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof1TWM2OD1zNEeuPFc5KM7:TR?= MofRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
OVCAR-8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF2NT62N|Yh|ryP M{\HN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
CP50-MEL-B MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonwTWM2OD1zNESuOVAyKM7:TR?= MkLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
COR-L88 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPLXGduUUN3ME2xOFIvOTRizszN NGjYd2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
Ca9-22 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF|OT64N|Mh|ryP MkTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
HCT-116 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF|Nz6yNVch|ryP NEHt[nk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
LB2518-MEL NUjxfpB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHHTZlwUUN3ME2xN|UvQTl|IN88US=> MmDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVA4QTF5NT:nQnNCVkeHUkyvZV4>
U-87-MG NEPwUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7sTWM2OD1zM{OuOlA1KM7:TR?= NFXhb3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
NCI-H2087 MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF|MT60PFMh|ryP M1H4cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
NCI-H1651 NGLHWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfj[5l7UUN3ME2xN|EvOjR|IN88US=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
A2780 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknKTWM2OD1zMkiuPVg5KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
BALL-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPiZZJJUUN3ME2xNlYvOjNizszN MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
COLO-679 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;rV|ZxUUN3ME2xNlYvPzV|IN88US=> M4nPVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
SF268 NV\RNWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF{Nj6xOVgh|ryP M3fLcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
SN12C MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljkTWM2OD1zMkSuNVc3KM7:TR?= NUPiN2h{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
NCI-H1770 NYX1d5c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTF{NT61NVQh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
NCI-H2452 NEL3UHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Q[pVKSzVyPUGyNk4zOSEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
SK-MEL-30 NGfEdIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7zTWM2OD1zMkOuNlQ1KM7:TR?= M3Xrb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
ML-2 NGXhS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfKTWM2OD1zMkGuOlc3KM7:TR?= M33sPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFExPzlzN{WvK|5USU6JRWK8M4E,
SW1990 NXrWWWw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W0[mlEPTB;MUKwMlk2OSEQvF2= NFXxN4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
D-392MG MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3mTWM2OD1zMUeuN|k5KM7:TR?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
NCI-H1793 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG4fo9vUUN3ME2xNFkvOjhizszN NXfrdodiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
GOTO Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFyNz63O|ch|ryP NYOye3g{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
HLE NH7yVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn22TWM2OD1zMEWuNlgzKM7:TR?= NHPCOJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
NCI-H209 MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXHTWM2OD1zMECuNVIyKM7:TR?= NHHrd5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyODd7MUe1M{c,W0GQR1XSQE9iRg>?
SW684 M3fFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTl6Lk[2OVQh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNFc6OTd3Lze+V2FPT0WUPD;hQi=>
NCI-H2029 NUXPOGVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTl4Lkm1OlYh|ryP NVK3WlhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTB5OUG3OU8oRlODTlfFVlww[T5?
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