MK-2206 2HCl

Catalog No.S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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Cited by 396 Publications

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Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)		 Akt2 [1]
(Cell-free assay)		 Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MULDfZRwfG:6aXOgRZN{[Xl? M4fPXlMh|ryP MoXMO|IhcA>? NYK5ZVhiTE2VTx?= NIHOcWtKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= NVz4dY9WOjB3N{GwOlk>
A431 MU\LbY5ie2ViQYPzZZk> MWC1JO69VQ>? MX[1JIg> NH\hSmdFVVOR MnK0V5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs MV6yNFU4OTB4OR?=
HepG2 M3O5b2N6fG:2b4jpZ{BCe3OjeR?= NGHLeY8yOCEQvF2= Mn76NlQhcA>? NYTSZ4VYTE2VTx?= NUP5WXNGW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj MYqyNVIxPTl{NR?=
Sk-Hep1 NVnhR5VVS3m2b4TvfIlkKEG|c3H5 NYHRdJlvOTBizszN MXWyOEBp M3HVd2ROW09? NInPb5VU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> MoT2NlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) NYPBd2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr0Wol{OyEQvF2= NGHvO3o2KGR? NW[4VVZKTE2VTx?= NE\6NYpKSzVyPUCuNVQh|ryP M{XPR|IyOjh7Mk[3
K1 cells harbored PIK3CA (E542K+/+) NV[yOVNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5eHN{OyEQvF2= NGjVTJI2KGR? MoD2SG1UVw>? MWfJR|UxRTBwNUKg{txO MWSyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) NW\nTppXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKzJO69VQ>? M3GxV|Uh\A>? MWrEUXNQ NYP0eXB2UUN3ME2wMlE5KM7:TR?= Ml3jNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) M4XIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn3TnV{OyEQvF2= MmXnOUBl Mn60SG1UVw>? MkDKTWM2OD1yLkK3JO69VQ>? M1HJZ|IyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInHVVE{KM7:TR?= MXi1JIQ> M3LCbWROW09? M3TTSWlEPTB;ND61JO69VQ>? MWSyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXWXWZKOyEQvF2= M2Xzb|Uh\A>? MYjEUXNQ M2X6[WlEPTB;MD61PUDPxE1? MmToNlEzQDl{Nke=
Hth74 NVrFdo5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jmOlMh|ryP MoLCOUBl NEXiTmRFVVOR NIexbmFKSzVyPUKuNVkh|ryP MWKyNVI5QTJ4Nx?=
KAT18 NEXBPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[0XVMh|ryP NWLETIo1PSCm M4rCUmROW09? M3PYcGlEPTB;ND62NkDPxE1? NGDHeHAzOTJ6OUK2Oy=>
SW1736 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuxNFAh|ryP NH7xRWc2KGR? MVvEUXNQ NHHCemhKSzVyPUS3MlU3KM7:TR?= MnXoNlEzQDl{Nke=
WRO MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml71NVAxOCEQvF2= NYO4SHZWPSCm Ml;iSG1UVw>? NGnEPWJKSzVyPkGwNFAh|ryP M1PiOVIyOjh7Mk[3
TAD2 MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNFAxKM7:TR?= MYe1JIQ> MV;EUXNQ M1PB[WlEPTB-MUCwNEDPxE1? NFL3[4EzOTJ6OUK2Oy=>
LN229 NU\TPWVsSXCxcITvd4l{KEG|c3H5 MYqwMlUh|ryP NGi3fGU3OCCq NVvXfo5FTE2VTx?= M2LxbmF2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk MknxNlIxPTd7MUS=
T98G MYDBdI9xfG:|aYOgRZN{[Xl? NULEcYNHOC53IN88US=> MW[2NEBp MYHEUXNQ NXzscotlSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= MVOyNlA2PzlzNB?=
HC11 NWnrSY1oTnWwY4Tpc44hSXO|YYm= NFvFPFgyOCEQvF2= M3XHV|I1KGh? NYTpWI5NTE2VTx?= MkTmTY5pcWKrdIOg{tIu[2G|ZXnuJIFv\CCDRGLQJJN6dnSqZYPpdy=> NVmxN|ZSOjJ2Mk[2NlE>
MOLT-4 NFfqb4NEgXSxdH;4bYMhSXO|YYm= NX7Yb|NrOTBizszN M{iyW|Q5KGh? Ml;XSG1UVw>? NWDxcmdCUUN3ME2xMlfjiIoQvF2= MWWyNlYyPDJ2Mx?=
CEM-R MX\DfZRwfG:6aXOgRZN{[Xl? M4jHO|ExKM7:TR?= M32wPVQ5KGh? M1vwcWROW09? MWrJR|UxRTNwM,MAje69VQ>? NITCdYMzOjZzNEK0Ny=>
CEM-S MVnDfZRwfG:6aXOgRZN{[Xl? M325Z|ExKM7:TR?= M3TkZlQ5KGh? NXf4W4RJTE2VTx?= MUnJR|UxRTVwMfMAje69VQ>? NIH6ZnkzOjZzNEK0Ny=>
MOLT-4 NWHzNXVQTnWwY4Tpc44hSXO|YYm= M1;RNlExKM7:TR?= NXHtW3ZMOjRiaB?= MX7EUXNQ NVu2VYdRSmyxY3vzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZTDv[kB1cGViY3XscEBkgWOuZR?= NIXudXIzOjZzNEK0Ny=>
MOLT-4 M{G0VWZ2dmO2aX;uJGF{e2G7 NF3lZ|M16oDLzszN M3H0VFQhcA>? NIHxT21FVVOR MVXJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> M1HFU|IzPjF2MkSz
CEM-R NYPRNIFSTnWwY4Tpc44hSXO|YYm= M2fPRVTjiIoQvF2= MorwOEBp MVnEUXNQ NVHYbWJUUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|RCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ M3fPbFIzPjF2MkSz
CEM-S M2ezRmZ2dmO2aX;uJGF{e2G7 NVzZbYRkPOLCid88US=> MoTmOEBp NV\RO5F{TE2VTx?= NVPtUohIUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|VCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ NIPOZYczOjZzNEK0Ny=>
HepG2 cell M3vM[WtqdmG|ZTDBd5NigQ>? M{fa[VIxKM7:TR?= NWT5epF1OjRiaB?= NFzuelVFVVOR NUfD[IhXTG:5boLl[5Vt[XSnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= NV32PJJFOjN5OUezNVk>
HepG2 cell NF34[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX3Nmg{OCEQvF2= NWrQWGh4OjRiaB?= NHfCe25FVVOR M4PqN2lvcGmkaYTzJINmdGxiZ4Lve5Rp NFjpPY0zOzd7N{OxPS=>
HepG2 cell MoLyRZBweHSxc3nzJGF{e2G7 Mnq0NlAh|ryP MlKyNlQhcA>? NFm0S|RFVVOR NWjWR2dCUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= MonyNlM4QTd|MUm=
GEO MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvNd3h4PTByIH7N NF7qfY44OiCq NHm0RpRFVVOR NFT4XmtKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NXzqNYxkOjR3OEGyN|E>
CNE-1 NIe0WGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6xNEDPxE1? NYHoS3lEQTZiaB?= NFrT[GxFVVOR M1XLXWlEPTB;Mj65OkDPxE1? NEnjWmEzPTN|NkmyOS=>
CNE-2 M4nQXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i3elExKM7:TR?= NH;jcIY6PiCq Mk\lSG1UVw>? Mn:xTWM2OD12LkWzJO69VQ>? NX\EPI1MOjV|M{[5NlU>
HONE-1 NVHa[|RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HyU|ExKM7:TR?= NFS4Row6PiCq Mo\tSG1UVw>? NFfLfoNKSzVyPUOuN|ch|ryP M3W0TVI2OzN4OUK1
SUNE-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\FNVAh|ryP NGG5UYY6PiCq NUnYbIlLTE2VTx?= M1m3PWlEPTB;MD61NkDPxE1? M4DmSVI2OzN4OUK1
CNE-2 MXjGeY5kfGmxbjDBd5NigQ>? NFqzWZgyOCEQvF2= Mn\1OFghcA>? NGLjNoVFVVOR Mn;rTY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? M3G0VlI2OzN4OUK1
HONE-1 NVu4eHNTTnWwY4Tpc44hSXO|YYm= MYexNEDPxE1? MVu0PEBp M4nid2ROW09? MkXpTY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? NWP4VFlrOjV|M{[5NlU>
NEC8 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rhUGlEPTB;MD6wPVY2OSEQvF2= NEDKR2dUSU6JRWK=
P12-ICHIKAWA MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUG2NkDPxE1? MXTTRW5ITVJ?
MDA-MB-175-VII M{jhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnmwTWM2OD1yLkGzO|M5KM7:TR?= MXrTRW5ITVJ?
AsPC-1 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHaTWM2OD1yLkKyNVIzKM7:TR?= MUPTRW5ITVJ?
T47D NUjFXmZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XE[mlEPTB;MD6yPFI2KM7:TR?= M2jRWnNCVkeHUh?=
HH NIHGT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwM{CyPFMh|ryP Mm\UV2FPT0WU
MOLT-16 NXPkUXMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILwSWVKSzVyPUCuN|A{OiEQvF2= NYj5WnBtW0GQR1XS
ES5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXWcpVKSzVyPUCuN|Q1PTVizszN NV;vdGw3W0GQR1XS
RS4-11 NF;IO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjLNm9KSzVyPUCuN|Q3OSEQvF2= M4[3cHNCVkeHUh?=
KARPAS-45 NGjQeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfiR49KSzVyPUCuN|c{OjFizszN NFfKZmVUSU6JRWK=
NCI-H720 M{jacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwM{e2O|kh|ryP MWTTRW5ITVJ?
H9 NEXMSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfacWVKSzVyPUCuN|g5QDNizszN MojTV2FPT0WU
EFM-19 NFjNU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vxe2lEPTB;MD60OFAyKM7:TR?= NX;ienpwW0GQR1XS
SBC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\TOGlEPTB;MD60OFA{PSEQvF2= MmfBV2FPT0WU
A4-Fuk MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme1TWM2OD1yLkS2PFY5KM7:TR?= NYTBboZ3W0GQR1XS
NCI-H1563 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnQOWczUUN3ME2wMlQ5OTh7IN88US=> M1uydHNCVkeHUh?=
HCC1419 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HYNGlEPTB;MD60PFg6OiEQvF2= M2i1VnNCVkeHUh?=
H-EMC-SS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwNEm5N|kh|ryP NETUUZBUSU6JRWK=
BHT-101 M3zLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrKN5NqUUN3ME2wMlUzQTZzIN88US=> MojJV2FPT0WU
IGROV-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwNUWyOFkh|ryP MoDmV2FPT0WU
HGC-27 MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0TWM2OD1yLkW2O|g{KM7:TR?= M{ny[3NCVkeHUh?=
MDA-MB-361 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7lTVFKSzVyPUCuOVc4PjFizszN MVzTRW5ITVJ?
KE-37 NEfVcnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW0SHlKSzVyPUCuOVgzPiEQvF2= NIL4VpNUSU6JRWK=
HCC70 NIW1WIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNUm4Nlch|ryP NFHWNI1USU6JRWK=
LNCaP-Clone-FGC NYrQPW9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLKd3JQUUN3ME2wMlYyODR6IN88US=> M1f1XHNCVkeHUh?=
HAL-01 NXqzOWZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr4TWM2OD1yLk[yNVMh|ryP M{H2O3NCVkeHUh?=
HT M{TORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LhbWlEPTB;MD62N|I{QSEQvF2= MWrTRW5ITVJ?
MDA-MB-415 NHLUb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr3Z4RZUUN3ME2wMlY{PjJ4IN88US=> MVvTRW5ITVJ?
NOS-1 Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLCTWM2OD1yLk[zO|I{KM7:TR?= NHjOUodUSU6JRWK=
DU-145 NXe0NIVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHIeWdEUUN3ME2wMlY1PzR3IN88US=> MnXTV2FPT0WU
OCUB-M MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwN{C5OlYh|ryP M{Dp[nNCVkeHUh?=
VA-ES-BJ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorvTWM2OD1yLkezNFI2KM7:TR?= MlfkV2FPT0WU
J-RT3-T3-5 NX:xdWlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\4XW5KSzVyPUCuO|Q1ODNizszN MoGyV2FPT0WU
MOLT-4 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHhd3piUUN3ME2wMlgxPTh{IN88US=> NG\5e2RUSU6JRWK=
NB7 NUnY[21ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXztemdyUUN3ME2wMlgzPDFzIN88US=> NWDEN4VzW0GQR1XS
L-363 NVHCbW1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknXTWM2OD1yLkizOFQzKM7:TR?= MkL4V2FPT0WU
NKM-1 M2\WWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzRTWM2OD1yLki2NlU{KM7:TR?= M1XlUnNCVkeHUh?=
HOP-92 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrzc49iUUN3ME2wMlg4OjJ|IN88US=> NGXaT2RUSU6JRWK=
OAW-42 NYHxSYNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTYTWM2OD1yLki4O|Ih|ryP NIj2RZVUSU6JRWK=
HuO9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwOUK3OVEh|ryP MWLTRW5ITVJ?
MFE-280 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki1TWM2OD1yLkm2OFY2KM7:TR?= NVXJTGtyW0GQR1XS
EM-2 M1jtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwOUe5N|kh|ryP MY\TRW5ITVJ?
NCI-H520 NHrCeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrqTWM2OD1yLkm4OVkzKM7:TR?= M2n5NHNCVkeHUh?=
LB2241-RCC NWDXSG1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHNTWM2OD1yLkm5O|M1KM7:TR?= NF7HVYVUSU6JRWK=
SK-NEP-1 NYG5dWZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\LfYNKSzVyPUGuNVQ1QDVizszN MnLKV2FPT0WU
LXF-289 NXHhN2lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33qT2lEPTB;MT6xO|E2PiEQvF2= NVTkXXBxW0GQR1XS
EPLC-272H NXLue5dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTHRYh7UUN3ME2xMlE4OjV4IN88US=> MmPsV2FPT0WU
COLO-684 NFTtZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGwZ2VWUUN3ME2xMlI{PzJ3IN88US=> NXjMd|RqW0GQR1XS
ES1 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HG[WlEPTB;MT6yOFA3PSEQvF2= NHTqNplUSU6JRWK=
DOHH-2 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml22TWM2OD1zLkK4NlA{KM7:TR?= MYPTRW5ITVJ?
CTB-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;3dnl2UUN3ME2xMlI5QTlizszN M{f3RnNCVkeHUh?=
G-401 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwMkm3PVUh|ryP NEXBcHJUSU6JRWK=
LoVo NX7NSWs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzVmlEPTB;MT6zNlU{PCEQvF2= NFnS[WpUSU6JRWK=
Ramos-2G6-4C10 M{D3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nWSWlEPTB;MT6zN|cxOSEQvF2= M4\3SnNCVkeHUh?=
MFM-223 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwM{S0OlEh|ryP NHLHN3JUSU6JRWK=
PA-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnuTWM2OD1zLkO1NlY2KM7:TR?= NETiRYdUSU6JRWK=
697 M3X0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXYTWM2OD1zLkO3OlE3KM7:TR?= MnfaV2FPT0WU
QIMR-WIL MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3WO4lKSzVyPUGuOFkyOTZizszN MVXTRW5ITVJ?
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CAL-54 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwN{GyOFIh|ryP NHnRO|FUSU6JRWK=
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BV-173 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T5b2lEPTB;MT64NVA4PCEQvF2= M1\XN3NCVkeHUh?=
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OC-314 MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j0SmlEPTB;Mj6xOVA5PiEQvF2= MX3TRW5ITVJ?
RMG-I M4C0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLTWM2OD1{LkG2N|k5KM7:TR?= NIfMT4NUSU6JRWK=
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DMS-114 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD0TWM2OD1|Lk[yNlc5KM7:TR?= NGf0SmJUSU6JRWK=
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KNS-62 NHnKfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzvOFBKSzVyPUOuOlM{OzhizszN NYfOfmVDW0GQR1XS
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G-402 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwN{C3NVEh|ryP MWjTRW5ITVJ?
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ECC10 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnaXnFtUUN3ME2zMlk{PjJ{IN88US=> NU\oXnVzW0GQR1XS
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LAMA-84 Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3TnhKSzVyPUSuNVQyQTFizszN Mn7GV2FPT0WU
Calu-3 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTRwMkS0NVYh|ryP M1uyWnNCVkeHUh?=
NCI-H460 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\LTHdKSzVyPUSuNlY1PDNizszN NYLubHBMW0GQR1XS
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HCE-T Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\YWJVKSzVyPUSuOFE2PzlizszN Mn3BV2FPT0WU
EW-11 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLVcFI4UUN3ME20MlQyQDN6IN88US=> NUfQVWl[W0GQR1XS
ATN-1 NGni[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnSTWM2OD12LkS0N|A1KM7:TR?= MVvTRW5ITVJ?
NB5 M2i1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRwNUO2PVch|ryP M1jpWXNCVkeHUh?=
KLE MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon1TWM2OD12LkewNVk5KM7:TR?= MlqxV2FPT0WU
CAL-39 NUL4T2U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRwN{KxOFYh|ryP NFTnN2xUSU6JRWK=
TI-73 M4TRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\JTWM2OD12LkiwOlA6KM7:TR?= M3\KOHNCVkeHUh?=
HO-1-N-1 NEHzVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrpTWM2OD12Lkm0NkDPxE1? NUHMVm11W0GQR1XS
786-0 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTRwOUS2O|Mh|ryP NHO4PFlUSU6JRWK=
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NCI-H446 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjY[45KSzVyPUWuNlAxODlizszN NYXEXJU{W0GQR1XS
ETK-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHQOXI{UUN3ME21MlIyOTZ3IN88US=> NYr6RXhDW0GQR1XS
BT-20 M3q2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm2TWM2OD13LkKxN|U{KM7:TR?= MlzzV2FPT0WU
MEL-HO NFvWbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j0fmlEPTB;NT6zO|M{PiEQvF2= MWrTRW5ITVJ?
CAL-27 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTVwNE[zN|kh|ryP MUjTRW5ITVJ?
SW872 NGK2[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rrfGlEPTB;NT61PVQzQCEQvF2= NFW5T21USU6JRWK=
RPMI-2650 MnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmxe|RKSzVyPUWuOlYyQTlizszN M2naPXNCVkeHUh?=
PFSK-1 NYP6dYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vtc2lEPTB;NT63Nlc{OiEQvF2= MYLTRW5ITVJ?
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Becker M2TpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTVwOE[0O|Ih|ryP MXHTRW5ITVJ?
Saos-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT3S|FPUUN3ME21Mlg3PTNizszN MVrTRW5ITVJ?
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BT-474 NGfmfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e1VWlEPTB;Nj6yN|Mh|ryP MkfDV2FPT0WU
BFTC-909 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjUOJZKSzVyPU[uN|A{PDVizszN MofJV2FPT0WU
NB12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTZwM{mwO|Eh|ryP NVHJbXRDW0GQR1XS
D-263MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTZwNEWxOlkh|ryP MonVV2FPT0WU
SNB75 NX7IemJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fjVGlEPTB;Nj62NFE1OyEQvF2= MYnTRW5ITVJ?
A704 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPzTWM2OD14Lk[zNFYh|ryP NGDVb5JUSU6JRWK=
NCI-H1693 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTZwNkO2NFQh|ryP NXTqTZpjW0GQR1XS
LN-405 M3LkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nESGlEPTB;Nj63PVY4OiEQvF2= MULTRW5ITVJ?
CHL-1 NFvrSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTZwOECwO|kh|ryP NVfDVWszW0GQR1XS
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TE-12 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmThTWM2OD14LkizPFE4KM7:TR?= NVLtWGNZW0GQR1XS
TE-6 M4PTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXhOYh{UUN3ME22Mlk{ODN6IN88US=> MXnTRW5ITVJ?
AU565 M3W2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iwNGlEPTB;Nj65Olk2PyEQvF2= NVj1N3VxW0GQR1XS
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NCI-H28 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jkWWlEPTB;Nz6yPVI1KM7:TR?= MU\TRW5ITVJ?
MC-IXC MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTdwNEi1O|Yh|ryP NYjBUG5LW0GQR1XS
GP5d M1PG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfLdGNKSzVyPUeuOFg4PjRizszN NWGzV5gyW0GQR1XS
GB-1 MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPZTWM2OD15LkW0PFA1KM7:TR?= NI[3OWdUSU6JRWK=
CAL-33 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHEU3ZKSzVyPUeuOlYzOzNizszN NVmzUIJzW0GQR1XS
MSTO-211H MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELIdVVKSzVyPUeuOlc{OzZizszN NYX6cWU6W0GQR1XS
TE-5 NH\RV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W3UmlEPTB;Nz63PVM{PCEQvF2= NVfuT4ZXW0GQR1XS
D-566MG NV33U2dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7rTWM2OD16LkC0OFI6KM7:TR?= M3TGRXNCVkeHUh?=
JVM-3 NX;VXYFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrZTWM2OD16LkG1NlY5KM7:TR?= MX7TRW5ITVJ?
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HCC1954 M4f0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G5bWlEPTB;OD60OVExPCEQvF2= MmHzV2FPT0WU
SF126 M{n1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3zTZIzUUN3ME24MlQ2QTN4IN88US=> NWHDXmg{W0GQR1XS
LB996-RCC NFTVS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS1TWM2OD16LkWzNlU4KM7:TR?= MXTTRW5ITVJ?
SKG-IIIa Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRThwNkOwOlkh|ryP MYnTRW5ITVJ?
NCI-SNU-1 NUnrSYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRThwNkS2OFMh|ryP MXnTRW5ITVJ?
LB771-HNC NUWxbZpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq5OHlKSzVyPUiuOlQ3QTZizszN NUHsNmR4W0GQR1XS
SCC-4 NGnMXHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3sTWM2OD16Lk[4NlE6KM7:TR?= MorLV2FPT0WU
CAMA-1 NUjucGkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PWe2lEPTB;OD63O|E1PiEQvF2= MULTRW5ITVJ?
D-502MG M{P6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPTTWM2OD16Lke4OlI6KM7:TR?= NWPNU|hyW0GQR1XS
ESS-1 NIjueVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfKTWM2OD16Lki4O|A1KM7:TR?= MV;TRW5ITVJ?
HEC-1 NVK0SXFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zwemlEPTB;OD64PVg3PiEQvF2= MnnwV2FPT0WU
NB10 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD17LkCyNlI1KM7:TR?= NF:0emVUSU6JRWK=
8505C NIn2PVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTmTWM2OD17LkC0NlMzKM7:TR?= NVu5TXNWW0GQR1XS
EFO-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGmzR3JKSzVyPUmuNVY1OTJizszN MkfXV2FPT0WU
HN MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXPNlRKSzVyPUmuNVY3OjhizszN NVzKZW95W0GQR1XS
DSH1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETveVVKSzVyPUmuNlA5PyEQvF2= MnnQV2FPT0WU
NBsusSR NYnOVHhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT1e4VKSzVyPUmuNlc1ODJizszN NVXrS41UW0GQR1XS
LS-123 NXHmdZcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTlwM{G3OlEh|ryP MUfTRW5ITVJ?
SHP-77 NIjQfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfTV|ZKSzVyPUmuN|k6OzVizszN NEC0VnNUSU6JRWK=
ACN M17qU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPZU2tKSzVyPUmuOVMzPzdizszN NHLTb4dUSU6JRWK=
U251 M{PhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fC[mlEPTB;OT62OVU1PCEQvF2= M{DYZXNCVkeHUh?=
A431 MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInVW2lKSzVyPUmuPFAzOzhizszN MkfBV2FPT0WU
5637 NEXC[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTlwOES5PFQh|ryP M2HoSXNCVkeHUh?=
MDA-MB-157 NYfSN2lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XRbWlEPTB;OT65Nlg4QCEQvF2= M1X0TXNCVkeHUh?=
A101D MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvoR5NKSzVyPUmuPVk6PzRizszN M2fvdXNCVkeHUh?=
YKG-1 NYHpZ4tOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3WS2VzUUN3ME2xNE4zODB4IN88US=> NWXNWFIyW0GQR1XS
LAN-6 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTJTWM2OD1zMD6yNVY1KM7:TR?= M{HOenNCVkeHUh?=
OVCAR-5 M3nnc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fZNGlEPTB;MUCuNlQ{OyEQvF2= MUjTRW5ITVJ?
A549 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFyLkO5O|Mh|ryP NIi1[pBUSU6JRWK=
no-11 NWPWO3FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHF[ot4UUN3ME2xNE41OzV|IN88US=> M{fzUXNCVkeHUh?=
SF539 MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPmPWxKSzVyPUGwMlkxPDFizszN NHux[nlUSU6JRWK=
A388 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLETWM2OD1zMT6zPFk4KM7:TR?= NVnSXY1WW0GQR1XS
DEL NHG2cXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;hdWlEPTB;MUGuOFI1KM7:TR?= NWT3VW53W0GQR1XS
SW954 M4TYe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITaT3hKSzVyPUGxMlQ3PjhizszN NHnpXVJUSU6JRWK=
TK10 NV\zOXd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHOTWM2OD1zMT61NlcyKM7:TR?= MUDTRW5ITVJ?
SW756 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFzLkWyPVQh|ryP MmfFV2FPT0WU
PC-3 NFrFb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPUb2xKSzVyPUGxMlU4PjRizszN M36zSHNCVkeHUh?=
ONS-76 M3TINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHFUXFKSzVyPUGxMlY{PiEQvF2= NIHUTVJUSU6JRWK=
A427 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn0fmN5UUN3ME2xNU44ODl|IN88US=> NWDMZnpIW0GQR1XS
MEG-01 M2HTVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS5TWM2OD1zMT63OVA6KM7:TR?= NWrRSWVbW0GQR1XS
BB30-HNC M{nkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TlRmlEPTB;MUGuO|k5OiEQvF2= M{PiPXNCVkeHUh?=
NCI-H1299 M3HXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHmTWM2OD1zMT64NFk{KM7:TR?= MYLTRW5ITVJ?
GCT M1vEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFzLkiyNlgh|ryP M1LXenNCVkeHUh?=
D-247MG NWPHRmFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTxRY1vUUN3ME2xNU46PjZ|IN88US=> M2fr[HNCVkeHUh?=
CFPAC-1 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO3[FVKSzVyPUGxMlk4QDJizszN M{e1ZXNCVkeHUh?=
EKVX MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF{LkCzNVMh|ryP MnfqV2FPT0WU
CAL-51 M3\zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCwUXZrUUN3ME2xNk4xPzF4IN88US=> M4PMXXNCVkeHUh?=
BB49-HNC NI\YZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDRUHFKSzVyPUGyMlEyPzdizszN M3vFZXNCVkeHUh?=
RPMI-7951 MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXsNGxFUUN3ME2xNk4yQDV2IN88US=> MXLTRW5ITVJ?
RH-1 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLXTWM2OD1zMj6yNVg1KM7:TR?= NIDxfY1USU6JRWK=
BCPAP MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfO[|JmUUN3ME2xNk41PzR7IN88US=> NIrNTYJUSU6JRWK=
GCIY MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF{LkWyNFkh|ryP MnjMV2FPT0WU
KNS-81-FD NXS3SXNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTF{LkW4Olkh|ryP NWrwZ3M5W0GQR1XS
KYSE-140 M2H4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF{Lki1PVUh|ryP NWDQXmhoW0GQR1XS
Ca-Ski NFfZ[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPie4NKSzVyPUGyMlkxPDFizszN M2TqeHNCVkeHUh?=
TGBC1TKB NEnkVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[yNGlEPTB;MUKuPVEyPSEQvF2= MYrTRW5ITVJ?
HCC1187 NYLrTZRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3joW2lEPTB;MUOuNVkyOiEQvF2= NYDw[YNtW0GQR1XS
SJSA-1 NICzRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu0TWM2OD1zMz6yN|I4KM7:TR?= M2GyfXNCVkeHUh?=
CTV-1 NFvSfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTF|LkO0OUDPxE1? MmnuV2FPT0WU
WM-115 NEPL[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLTfotKSzVyPUGzMlY1QDNizszN NEjxR2FUSU6JRWK=
CHP-212 M3[1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLYTWM2OD1zMz65O|M6KM7:TR?= M2f0bHNCVkeHUh?=
SCC-15 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzjUVRKSzVyPUGzMlk4PzVizszN NVXZS5VEW0GQR1XS
BPH-1 NYS5V2lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojZTWM2OD1zND6xOlY1KM7:TR?= M3LaU3NCVkeHUh?=
SW780 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3PXYVPUUN3ME2xOE42ODJ3IN88US=> M4q4U3NCVkeHUh?=
NCI-H2291 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnFeWJKSzVyPUG0MlU5PzhizszN MofiV2FPT0WU
JEG-3 NIfLVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1TFFKSzVyPUG0MlY{OjZizszN MXfTRW5ITVJ?
CAL-120 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF2LkewNlch|ryP NYLnV4t5W0GQR1XS
NCI-H23 M3rOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnRTWM2OD1zND63PVk4KM7:TR?= MXfTRW5ITVJ?
MS-1 NUTne2ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrCR|lKSzVyPUG0Mlk3OTFizszN MknIV2FPT0WU
PC-14 M2L3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITrXotKSzVyPUG0Mlk3PTRizszN NILxZlhUSU6JRWK=
D-283MED NIrwb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTNTWM2OD1zNT6wNVEyKM7:TR?= MV3TRW5ITVJ?
OE19 NIHSblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfIWohKSzVyPUG1MlE2PDFizszN M2nPSnNCVkeHUh?=
CAS-1 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfpTWM2OD1zNT60NVg1KM7:TR?= Mn\XV2FPT0WU
NCI-H727 M1LOfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTF3LkSyNlEh|ryP MnHRV2FPT0WU
SiHa MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK0TWM2OD1zNT63OVk1KM7:TR?= MXjTRW5ITVJ?
BFTC-905 NEnEOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDjRZZKSzVyPUG1Mlc3QTRizszN M3zCTXNCVkeHUh?=
MDA-MB-453 MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ZT2lKSzVyPUG2MlE3PDJizszN NXTlU4hNW0GQR1XS
HuP-T3 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfiVWVKSzVyPUG2MlY{PzNizszN NGTyOGFUSU6JRWK=
SK-LU-1 NXnVeIlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zU[mlEPTB;MU[uOlk2PiEQvF2= M3LsN3NCVkeHUh?=
Detroit562 NEm4eIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXZTWM2OD1zNj63N|E5KM7:TR?= NUK3WXRwW0GQR1XS
HCC1569 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD4O|hKSzVyPUG2Mlg{OzdizszN NUflTW8yW0GQR1XS
SK-MES-1 NIXHSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XTfWlEPTB;MU[uPFQyQSEQvF2= MXfTRW5ITVJ?
BB65-RCC NH61dmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF5LkC0O|kh|ryP M3jQeHNCVkeHUh?=
LOXIMVI NEm3N4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jWNGlEPTB;MUeuNFcxPyEQvF2= MX;TRW5ITVJ?
SW1783 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HlcGlEPTB;MUeuNVI5KM7:TR?= Mmi5V2FPT0WU
NH-12 NI\hOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF5LkOzNFMh|ryP NF\E[2FUSU6JRWK=
UACC-257 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTBPYVyUUN3ME2xO{42PTF{IN88US=> NXv2d4hvW0GQR1XS
KOSC-2 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorTTWM2OD1zNz62O|U4KM7:TR?= M4n0Z3NCVkeHUh?=
KG-1 NI\xeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[5S41SUUN3ME2xO{43QTN5IN88US=> NFu3OpBUSU6JRWK=
M059J M3K0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjrNVRKSzVyPUG3MlcxOyEQvF2= NEfP[oVUSU6JRWK=
MHH-NB-11 NHjUbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnRWYlKSzVyPUG3Mlk3PzNizszN M2\sOXNCVkeHUh?=
EW-1 NYr0VW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLNfoZKSzVyPUG4MlE{QDJizszN M17XVHNCVkeHUh?=
CAL-85-1 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\6TWM2OD1zOD6yN|U4KM7:TR?= M4CwfHNCVkeHUh?=
639-V NHTNV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXtTHk2UUN3ME2xPE4{OzV2IN88US=> M2DXbHNCVkeHUh?=
C32 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HxR2lEPTB;MUiuOFczPyEQvF2= MVjTRW5ITVJ?
KM-H2 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;XZVE4UUN3ME2xPE42OjN{IN88US=> MYfTRW5ITVJ?
A253 NX\S[YR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vkTWlEPTB;MUiuO|I5PiEQvF2= NXPYNldNW0GQR1XS
NCI-N87 NVvUZVY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\1WYdKSzVyPUG4MlkxODhizszN NVLEfXFiW0GQR1XS
8-MG-BA M2O1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGzOmM1UUN3ME2xPU4xPjR4IN88US=> NFrlV3RUSU6JRWK=
GI-ME-N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPUOpVKSzVyPUG5MlE2PDZizszN MXjTRW5ITVJ?
8305C MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP5SJVKSzVyPUG5MlIzQDZizszN NF72V5FUSU6JRWK=
TE-8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInXcHFKSzVyPUG5MlMxOjRizszN M4LkTXNCVkeHUh?=
KYSE-270 NX\Rd2t5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHrbVlKSzVyPUKwMlAzOTdizszN Mm\tV2FPT0WU
HL-60 NHv2TZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3BbVVKSzVyPUKwMlA6PDFizszN MYHTRW5ITVJ?
Mo-T M1;N[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJyLkG2OlUh|ryP MV\TRW5ITVJ?
NCI-H1355 NF3DTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XpVmlEPTB;MkCuN|M4PCEQvF2= MYLTRW5ITVJ?
HT-1080 NF\sTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJyLkW0PVch|ryP Mnq3V2FPT0WU
MIA-PaCa-2 NEnv[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnucFJKSzVyPUKwMlY5QDNizszN Ml3RV2FPT0WU
NCI-H441 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJyLkezO|kh|ryP NWDlenY6W0GQR1XS
LCLC-97TM1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITORWdKSzVyPUKwMlgyOzRizszN NFjzc49USU6JRWK=
HT-3 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\HWmlEPTB;MkGuOVY{OSEQvF2= M{XMNHNCVkeHUh?=
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LK-2 NVrrdm9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrIc3pKSzVyPUKxMlU6PTNizszN M2T0VHNCVkeHUh?=
CW-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPld2NKSzVyPUKxMlYxPjlizszN MofyV2FPT0WU
KYSE-510 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2ybGRKSzVyPUKxMlYxQTVizszN NIm3PG5USU6JRWK=
CGTH-W-1 M4jqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ezOGlEPTB;MkGuO|E3PiEQvF2= MmnsV2FPT0WU
NCI-H661 NFLxW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\YTIdKSzVyPUKyMlA{PCEQvF2= M3iwZXNCVkeHUh?=
KU-19-19 NFrJSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKZWlEPTB;MkKuNVY6PyEQvF2= MXTTRW5ITVJ?
NCI-H2122 NGLnTmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ{LkK0N|Ih|ryP M4Ly[3NCVkeHUh?=
NCI-H526 M3HhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXkTFRNUUN3ME2yNk4{QDl3IN88US=> M4HYbHNCVkeHUh?=
NCI-H1650 NGK3[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjhbJNKSzVyPUKyMlc3PCEQvF2= NHPvXHlUSU6JRWK=
AM-38 NUnlUnlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6OYZKSzVyPUKyMlg3QDlizszN Mk\OV2FPT0WU
NCI-H2405 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTmTWM2OD1{Mz6yOVM{KM7:TR?= NWD6T3BlW0GQR1XS
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KY821 NGHTNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqwTWM2OD16ND6wPFkzKM7:TR?= MX7TRW5ITVJ?
DoTc2-4510 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rwNGlEPTB;OESuNlE5PSEQvF2= MkjvV2FPT0WU
NCI-H1581 M2GxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rucmlEPTB;OEWuOFY1OSEQvF2= MlvxV2FPT0WU
KARPAS-299 Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPCN3FKSzVyPUi2MlE6PzdizszN MlS2V2FPT0WU
IST-MEL1 NHHxXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS2[o1HUUN3ME24Ok45QDd{IN88US=> MW\TRW5ITVJ?
KP-N-YS MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Qd4lJUUN3ME24PU46ODJ6IN88US=> NYTQPYtKW0GQR1XS
KYSE-410 MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzkNW9KSzVyPUmxMlQxPDJizszN M4rSR3NCVkeHUh?=
TE-10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTlzLkW2NVEh|ryP NGDESYxUSU6JRWK=
SK-MEL-1 M3HKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL6[2NKSzVyPUmyMlkyODZizszN MYPTRW5ITVJ?
COLO-792 Mkn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HlRmlEPTB;OUWuNlU3PCEQvF2= NX7PfJd3W0GQR1XS
SCH MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlGyTWM2OD17Nj6zPFc4KM7:TR?= NHXVcGZUSU6JRWK=
NCI-H1792 MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfRTWM2OD17Nj64PVkzKM7:TR?= NH;CcYJUSU6JRWK=
NCI-H2029 MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj0TWM2OD17Nj65OVY3KM7:TR?= M1joUXNCVkeHUh?=
SW684 NX21e4dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTl6Lk[2OVQh|ryP NG\oUJhUSU6JRWK=
NCI-H209 NGjuU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfnTWM2OD1zMECuNVIyKM7:TR?= NVXKcmxbW0GQR1XS
HLE NHvLd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFyNT6yPFIh|ryP M3nvOXNCVkeHUh?=
GOTO NYjFcJczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r6fmlEPTB;MUC3Mlc4PyEQvF2= M4m2W3NCVkeHUh?=
NCI-H1793 M3rv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFyOT6yPEDPxE1? NI\0O|JUSU6JRWK=
D-392MG M1PPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D2VWlEPTB;MUG3MlM6QCEQvF2= NF\OPJNUSU6JRWK=
SW1990 NGf3OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTMVW1FUUN3ME2xNlAvQTVzIN88US=> MWHTRW5ITVJ?
ML-2 M{LvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL4TIxKSzVyPUGyNU43PzZizszN M2exRXNCVkeHUh?=
NCI-H2452 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHyO5BKSzVyPUGyNk4zOSEQvF2= MoPEV2FPT0WU
SK-MEL-30 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:xV2VrUUN3ME2xNlMvOjR2IN88US=> Mn;mV2FPT0WU
SN12C NEDLPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm1RW1KUUN3ME2xNlQvOTd4IN88US=> M4XaT3NCVkeHUh?=
NCI-H1770 NWTI[FZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr6NY9KSzVyPUGyOU42OTRizszN NE[1W|VUSU6JRWK=
SF268 M1vBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;JfGlEPTB;MUK2MlE2QCEQvF2= M1HLW3NCVkeHUh?=
BALL-1 NXTGeo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml36TWM2OD1zMk[uNlMh|ryP NFnJS3VUSU6JRWK=
COLO-679 NHHVW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF{Nj63OVMh|ryP NFj2bWtUSU6JRWK=
A2780 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf2TWM2OD1zMkiuPVg5KM7:TR?= NYjPXnpRW0GQR1XS
NCI-H1651 NIjKenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF|MT6yOFMh|ryP NWHmPWdTW0GQR1XS
NCI-H2087 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPiclExUUN3ME2xN|EvPDh|IN88US=> NH\T[lNUSU6JRWK=
U-87-MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTzTWM2OD1zM{OuOlA1KM7:TR?= MUHTRW5ITVJ?
LB2518-MEL NIfPb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF|NT65PVMh|ryP NVzQTXdFW0GQR1XS
HCT-116 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nRdmlEPTB;MUO3MlIyPyEQvF2= MXrTRW5ITVJ?
Ca9-22 M3GyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF|OT64N|Mh|ryP NVjaS5puW0GQR1XS
COR-L88 M{H4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vQd2lEPTB;MUSyMlE1KM7:TR?= NFOyW4pUSU6JRWK=
CP50-MEL-B Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnCNmpKSzVyPUG0OE42ODFizszN M4rHUXNCVkeHUh?=
OVCAR-8 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF2NT62N|Yh|ryP MkSxV2FPT0WU
SK-MEL-3 NUT4O|g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX2cG5tUUN3ME2xOFcvQDd6IN88US=> NIjhNHJUSU6JRWK=
GT3TKB NHzDNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF2OT65Nlgh|ryP MXzTRW5ITVJ?
KYSE-450 M4DTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\MOZRKSzVyPUG1NU42OzlizszN NVvGXHBbW0GQR1XS
CAPAN-1 NXXqT29IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T4NmlEPTB;MUWzMlA3PCEQvF2= NHLye|lUSU6JRWK=
BEN NVXUSIxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7SWINKUUN3ME2xOVMvQTJ6IN88US=> NI\vbHBUSU6JRWK=
NCI-H1304 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHQTWM2OD1zNUSuOlk1KM7:TR?= MXnTRW5ITVJ?
KU812 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF3OD62O|Qh|ryP Mm\QV2FPT0WU
Capan-2 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnsTWM2OD1zNkCuOVU{KM7:TR?= M4T2OHNCVkeHUh?=
A673 NH;Q[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknuTWM2OD1zNkGuO|A2KM7:TR?= MWLTRW5ITVJ?
SAS MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF4Mj62O|gh|ryP M4LqbHNCVkeHUh?=
NY MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHvbGlKSzVyPUG2OU4{OTRizszN NIrablNUSU6JRWK=
HCE-4 NH7lb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjvTWM2OD1zNk[uPFQ2KM7:TR?= NWe4RZhwW0GQR1XS
MDA-MB-231 NUTnd|J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf5TWM2OD1zN{euOVA{KM7:TR?= MnnGV2FPT0WU
no-10 NFHoRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe0O2hKSzVyPUG3PE4yOzRizszN MoPWV2FPT0WU
MZ7-mel NU\afnlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF5OD60Olch|ryP MYXTRW5ITVJ?
NCI-H82 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj2TWM2OD1zOECuNVY2KM7:TR?= MXnTRW5ITVJ?
CAL-72 NGPpWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\GemlEPTB;MUi1MlA2PCEQvF2= NXTMZ2lMW0GQR1XS
NCI-SNU-5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF6Nj64OEDPxE1? MkixV2FPT0WU
OVCAR-4 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF6OD6zN|Mh|ryP MUDTRW5ITVJ?
SCC-9 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOyc2xKSzVyPUG5NUDPxE1? MWrTRW5ITVJ?
KYSE-150 M2DhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT1U4hsUUN3ME2xPVEvQDh6IN88US=> MUTTRW5ITVJ?
HT-29 NHzIT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJyMT6yNVIh|ryP NWH2SYF6W0GQR1XS
COLO-678 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfmTpRKSzVyPUKwNU41PSEQvF2= NULG[5U{W0GQR1XS
NCI-H650 NUfJ[5JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjJTWM2OD1{MEKuNVA{KM7:TR?= MU\TRW5ITVJ?
HuCCT1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlThTWM2OD1{MESuNlA5KM7:TR?= M1TOOnNCVkeHUh?=
SW1116 M{TTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJyNz6wO|ch|ryP NGfHbXdUSU6JRWK=
DBTRG-05MG NGruUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJyNz65NFkh|ryP NWnWdY12W0GQR1XS
SW982 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPUTWM2OD1{MEeuPVQ5KM7:TR?= MoXkV2FPT0WU
RCM-1 NG\TdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH36UWVKSzVyPUKxOE44PjJizszN MWDTRW5ITVJ?
COLO-320-HSR M1\2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPwcXRKSzVyPUKxOk4yOjVizszN M3zxNnNCVkeHUh?=
KNS-42 M{Dn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTsOI1rUUN3ME2yNVYvPTd2IN88US=> NUWxOHE3W0GQR1XS
C2BBe1 NVjUeGdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPJTWM2OD1{M{GuPVA2KM7:TR?= MUHTRW5ITVJ?
CCRF-CEM M4DtbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq5TXVKSzVyPUK0N{44QTVizszN MkPHV2FPT0WU
SH-4 NXvpWmRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PkcmlEPTB;MkS2MlA6KM7:TR?= NHLLZ3FUSU6JRWK=
LS-1034 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;ZVGNrUUN3ME2yOFYvOjZ4IN88US=> NYW5dZVrW0GQR1XS
NCI-H2347 M2HXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ2Nz63NVMh|ryP MkL1V2FPT0WU
RPMI-8866 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fkV2lEPTB;MkS5MlI4KM7:TR?= M4TrVHNCVkeHUh?=
GAK MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHoTWM2OD1{NUOuNFAzKM7:TR?= MnfCV2FPT0WU
NB6 M4ewXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf1RYZCUUN3ME2yO|AvOSEQvF2= NGn0fnJUSU6JRWK=
COLO-680N NXnxRlgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rLOGlEPTB;MkeyMlUzPyEQvF2= NUTneW81W0GQR1XS
RERF-LC-MS NEjQbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W2U2lEPTB;Mke2MlAxPyEQvF2= NXK3cZdlW0GQR1XS
TGBC11TKB MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmzXFB2UUN3ME2yO|gvOTd6IN88US=> NX7CNW1jW0GQR1XS
C8166 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJ5OD61NFYh|ryP NIf6fmpUSU6JRWK=
HDLM-2 NXX4dVdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ7ND60NFkh|ryP MUfTRW5ITVJ?
IGR-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrBTWM2OD1{OUWuOlU6KM7:TR?= MYLTRW5ITVJ?
FADU M3LROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzmPHM{UUN3ME2yPVcvPTFizszN NX\XdJAxW0GQR1XS
L-428 NHnJRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrQcW1KSzVyPUK5O{43OTZizszN MlTTV2FPT0WU
LU-65 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNyND6zNkDPxE1? M4f1PXNCVkeHUh?=
HEL NF\XRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLRWZVyUUN3ME2zNFkvQTh|IN88US=> MlX0V2FPT0WU
NCI-H810 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNzMD61O{DPxE1? NFjEUWJUSU6JRWK=
C3A NGm1[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNzMT64NFIh|ryP MX;TRW5ITVJ?
NCI-H630 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTN|Mj6yPVQh|ryP M3W2enNCVkeHUh?=
KP-N-YN NXPRPI9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTN2MT6xNlMh|ryP Mm\RV2FPT0WU
MOLT-13 NILFWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj4V4hKSzVyPUO0Nk4{OjZizszN NIH4[|lUSU6JRWK=
NCI-H1993 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjkTWM2OD1|NEKuN|Y2KM7:TR?= NFTBT3ZUSU6JRWK=
BE-13 NH3hXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTN2ND6xOlch|ryP MkLmV2FPT0WU
IST-SL1 NH\FZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN2Nz60NFEh|ryP M2T0OnNCVkeHUh?=
TE-9 MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17Mc2lEPTB;M{[zMlU5QSEQvF2= NEn6N4pUSU6JRWK=
LU-135 NFHEXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjyW3lKSzVyPUO2O{4xOzVizszN MWDTRW5ITVJ?
T84 NGC5PItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXMbW1KSzVyPUO3OE44OTJizszN M4fzXnNCVkeHUh?=
K-562 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfRTWM2OD1|OEOuN|Yh|ryP MVnTRW5ITVJ?
SBC-5 NF[3TGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorPTWM2OD1|OE[uPVg2KM7:TR?= Mk\6V2FPT0WU
NB17 NGfPdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm4TWM2OD1|OUKuOVk3KM7:TR?= M2fBNXNCVkeHUh?=
NCI-H2052 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLXTWM2OD1|OUiuOFczKM7:TR?= M1jCXXNCVkeHUh?=
HCC38 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjDPI5KSzVyPUSwNU42QTNizszN MkHiV2FPT0WU
NCI-H69 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDHTWM2OD12NEGuNFg{KM7:TR?= NFf5UZhUSU6JRWK=

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]
+ Expand

Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]
+ Expand
  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]
+ Expand
  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Formulation: Formulated in 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing. 		17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl
CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01802320 Active not recruiting Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer National Cancer Institute (NCI) March 2013 Phase 2
NCT01802320 Active not recruiting Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer National Cancer Institute (NCI) March 2013 Phase 2
NCT01859182 Withdrawn Adenocarcinoma of the Gallbladder|Adenocarcinoma With Squamous Metaplasia of the Gallbladder|Adult Primary Cholangiocellular Carcinoma|Advanced Adult Primary Liver Cancer|Cholangiocarcinoma of the Extrahepatic Bile Duct|Localized Unresectable Adult Primary Liver Cancer|Metastatic Extrahepatic Bile Duct Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Stage II Gallbladder Cancer|Stage IIIA Gallbladder Cancer|Stage IIIB Gallbladder Cancer|Stage IVA Gallbladder Cancer|Stage IVB Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer National Cancer Institute (NCI) January 2013 Phase 2
NCT01783171 Completed Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Unresectable Pancreatic Carcinoma National Cancer Institute (NCI) January 15 2013 Phase 1
NCT01776008 Terminated Estrogen Receptor Positive|HER2/Neu Negative|Recurrent Breast Carcinoma|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer National Cancer Institute (NCI) January 2013 Phase 2
NCT01859182 Withdrawn Adenocarcinoma of the Gallbladder|Adenocarcinoma With Squamous Metaplasia of the Gallbladder|Adult Primary Cholangiocellular Carcinoma|Advanced Adult Primary Liver Cancer|Cholangiocarcinoma of the Extrahepatic Bile Duct|Localized Unresectable Adult Primary Liver Cancer|Metastatic Extrahepatic Bile Duct Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Stage II Gallbladder Cancer|Stage IIIA Gallbladder Cancer|Stage IIIB Gallbladder Cancer|Stage IVA Gallbladder Cancer|Stage IVB Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer National Cancer Institute (NCI) January 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

selleck catalog

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

  • Selective Akt Inhibitor

    CCT128930 : AKT2-selective, IC50=6 nM.

  • Most Potent Akt Inhibitor

    AZD5363 : Akt1, IC50=3 nM; Akt2, IC50=8 nM; Akt3, IC50=8 nM.

  • Akt Inhibitor in Clinical Trial

    Perifosine (KRX-0401) : Phase III fro relapsed and refractory multiple myeloma.

  • Newest Akt Inhibitor

    AZD5363 : Potent inhibitor of all isoforms of Akt (Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM, similar to P70S6K/PKA and lower activity towards ROCK1/2.

Related Akt Products4

  • Afuresertib (GSK2110183) New

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • AT13148 New

    AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

  • SC79 New

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

  • Capivasertib (AZD5363)

    AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • Ipatasertib (GDC-0068)

    Ipatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.

  • GSK690693

    GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

  • A-674563

    A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.

    Features:Orally bioavailable compound (achieved by replacing indole of A-443654 with phenyl moiety) and somewhat less selective for Akt over PKA than A-443654.

  • Triciribine

    Triciribine is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.

  • Honokiol

    Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID