MK-2206 2HCl

Catalog No.S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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In DMSO USD 220 In stock
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Cited by 937 Publications

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MYHDfZRwfG:6aXOgRZN{[Xl? MYSzJO69VQ>? Ml:1O|IhcA>? M13mXmROW09? MmfuTY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25? NEi0cpEzODV5MUC2PS=>
A431 M4qzPWtqdmG|ZTDBd5NigQ>? NGT5ZXc2KM7:TR?= MY[1JIg> NHXhbJpFVVOR MljOV5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs MonhNlA2PzFyNkm=
HepG2 MmX2R5l1d3SxeHnjJGF{e2G7 NWHmfFBoOTBizszN NWP4UZozOjRiaB?= NXjCVIJCTE2VTx?= NUT5PGF3W2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj MV[yNVIxPTl{NR?=
Sk-Hep1 M2PLcmN6fG:2b4jpZ{BCe3OjeR?= M3jHPVExKM7:TR?= NFPHXWszPCCq M4[5eGROW09? NVTWNmVpW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj NEXJZmYzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO5N{DPxE1? M{fI[lUh\A>? NXTrc2pPTE2VTx?= Ml7yTWM2OD1yLkG0JO69VQ>? M2nLZlIyOjh7Mk[3
K1 cells harbored PIK3CA (E542K+/+) M3XaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fGS|Mh|ryP M2TnPVUh\A>? NIXROmdFVVOR MXrJR|UxRTBwNUKg{txO Mmj6NlEzQDl{Nke=
FTC133 cells harbored PTEN (allele deletion and R130+) MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPkN{DPxE1? M4DQWVUh\A>? M2i0SWROW09? MX3JR|UxRTBwMUig{txO Ml\jNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) NVT5e|JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLhNmViOyEQvF2= M{ntS|Uh\A>? MVLEUXNQ NXjuV3ZQUUN3ME2wMlI4KM7:TR?= Ml23NlEzQDl{Nke=
Hth7 cells harbored NRAS (Q61R+/−) M1fSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYizJO69VQ>? Mor6OUBl NVfuRm16TE2VTx?= M{HtUWlEPTB;ND61JO69VQ>? MYWyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPoTmRDOyEQvF2= MU[1JIQ> NVXUVGpWTE2VTx?= Mo\QTWM2OD1yLkW5JO69VQ>? M2HmO|IyOjh7Mk[3
Hth74 NE\sbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[zJO69VQ>? M33Y[VUh\A>? Mme2SG1UVw>? MmjyTWM2OD1{LkG5JO69VQ>? NYHqNWVWOjF{OEmyOlc>
KAT18 M3;BTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;pOVMh|ryP MYq1JIQ> NIHjOmNFVVOR NX\UTIpzUUN3ME20MlYzKM7:TR?= MVKyNVI5QTJ4Nx?=
SW1736 MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvkRooyODBizszN MWm1JIQ> NXH5c|hDTE2VTx?= M1HsOWlEPTB;NEeuOVYh|ryP MViyNVI5QTJ4Nx?=
WRO NUn2ZXpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ENVAxOCEQvF2= NVTHV3RkPSCm M3HlNGROW09? MXvJR|UxRjFyMECg{txO M2nhPVIyOjh7Mk[3
TAD2 NVy5VXpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyd2E1OTByMDFOwG0> Moq3OUBl NEfG[VNFVVOR MVPJR|UxRjFyMECg{txO NYrhS|F3OjF{OEmyOlc>
LN229 MnfKRZBweHSxc3nzJGF{e2G7 NEPERo0xNjVizszN Mn3COlAhcA>? MXHEUXNQ MVzBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? NH7WSlgzOjB3N{mxOC=>
T98G Mn\ORZBweHSxc3nzJGF{e2G7 MV:wMlUh|ryP MlvrOlAhcA>? MonJSG1UVw>? M{jqZWF2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk M162UFIzODV5OUG0
HC11 M4PT[GZ2dmO2aX;uJGF{e2G7 NUf0T5p4OTBizszN M2W5b|I1KGh? M2r2S2ROW09? M3LBS2lvcGmkaYTzJO6zNWOjc3XpckBidmRiQVTSVEB{gW62aHXzbZM> NILRcogzOjR{Nk[yNS=>
MOLT-4 NYDtW|V2S3m2b4TvfIlkKEG|c3H5 M332e|ExKM7:TR?= MlfuOFghcA>? Mo\vSG1UVw>? MX;JR|UxRTFwN,MAje69VQ>? NIG5VmkzOjZzNEK0Ny=>
CEM-R MlvGR5l1d3SxeHnjJGF{e2G7 NUXZ[JBXOTBizszN MkPFOFghcA>? Ml3RSG1UVw>? NGLib3BKSzVyPUOuN-KBkc7:TR?= NX;xcIdjOjJ4MUSyOFM>
CEM-S MXnDfZRwfG:6aXOgRZN{[Xl? MkG2NVAh|ryP M130cFQ5KGh? MkfCSG1UVw>? MlLtTWM2OD13LkJihKnPxE1? MYiyNlYyPDJ2Mx?=
MOLT-4 NG\UT3VHfW6ldHnvckBCe3OjeR?= MV2xNEDPxE1? MmfNNlQhcA>? M{HBcGROW09? MmXwRoxw[2u|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? MkjlNlI3OTR{NEO=
MOLT-4 MVLGeY5kfGmxbjDBd5NigQ>? MlmyOQKBkc7:TR?= NX;jPWpFPCCq M4\DemROW09? NITBPHJKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDN2EwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? MV:yNlYyPDJ2Mx?=
CEM-R NV73[YxZTnWwY4Tpc44hSXO|YYm= NXjxbnZZPOLCid88US=> MWC0JIg> NVfO[W5NTE2VTx?= MoPVTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{TBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz MoHyNlI3OTR{NEO=
CEM-S NFvMVXJHfW6ldHnvckBCe3OjeR?= MYS05qCK|ryP M2nXeVQhcA>? NF3F[oZFVVOR M2LaOWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NWfLVVd3OjJ4MUSyOFM>
HepG2 cell NXrPW4FTU2mwYYPlJGF{e2G7 MoHPNlAh|ryP Mlq4NlQhcA>? M2m4T2ROW09? MULEc5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[gRWtV MlXjNlM4QTd|MUm=
HepG2 cell NUjLTlByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjuVJNHOzBizszN Mn;KNlQhcA>? NHPIbGZFVVOR NXLPXY42UW6qaXLpeJMh[2WubDDndo94fGh? NEflVW8zOzd7N{OxPS=>
HepG2 cell MUXBdI9xfG:|aYOgRZN{[Xl? NVHGW4RKOjBizszN MW[yOEBp NFLHe2hFVVOR MW\JcoR2[2W|IHPlcIwh[XCxcITvd4l{ MX6yN|c6PzNzOR?=
GEO MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPn[YlOPTByIH7N M{Xp[VczKGh? MoLWSG1UVw>? NU\CUlc5UW6qaXLpeJMh[2WubDDndo94fGh? M1jrclI1PThzMkOx
CNE-1 NYnJcYNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfROHFROTBizszN M{TuSFk3KGh? MUPEUXNQ MXHJR|UxRTJwOU[g{txO MoLjNlU{OzZ7MkW=
CNE-2 NILJNFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULKdHl7OTBizszN M1HmeVk3KGh? NGjtZZZFVVOR M3LaWGlEPTB;ND61N{DPxE1? NFLXeYQzPTN|NkmyOS=>
HONE-1 M2L5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\CNVAh|ryP NWrxbmlCQTZiaB?= NXr6OGNqTE2VTx?= MWLJR|UxRTNwM{eg{txO M{DUNFI2OzN4OUK1
SUNE-1 M4rtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET0bnUyOCEQvF2= NV3nV4NzQTZiaB?= MWfEUXNQ NVHpe256UUN3ME2wMlUzKM7:TR?= M4Pyc|I2OzN4OUK1
CNE-2 NWe1PXdPTnWwY4Tpc44hSXO|YYm= MknLNVAh|ryP NHW0TGY1QCCq NGjD[|BFVVOR MV;JcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy NGnRSokzPTN|NkmyOS=>
HONE-1 MXTGeY5kfGmxbjDBd5NigQ>? NVm5PG1OOTBizszN NFTNboM1QCCq NWfqRmVtTE2VTx?= MljmTY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? NHfxfZAzPTN|NkmyOS=>
NEC8 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK2bHNuUUN3ME2wMlA6PjVzIN88US=> M4\yR3NCVkeHUh?=
P12-ICHIKAWA NEPIbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnlWYlqUUN3ME2wMlEyPjJizszN NXP4TXVwW0GQR1XS
MDA-MB-175-VII MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;QTWM2OD1yLkGzO|M5KM7:TR?= NHvLbo1USU6JRWK=
AsPC-1 NH7KeVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMkKxNlIh|ryP NICxdmhUSU6JRWK=
T47D MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMkiyOUDPxE1? NHHUS2RUSU6JRWK=
HH M3v0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT2SI9KSzVyPUCuN|AzQDNizszN M3zvcnNCVkeHUh?=
MOLT-16 NYnCW2FLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwM{CzNkDPxE1? M1ezbnNCVkeHUh?=
ES5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfQdJk6UUN3ME2wMlM1PDV3IN88US=> NX3xZnhrW0GQR1XS
RS4-11 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP5XnR7UUN3ME2wMlM1PjFizszN Mkn4V2FPT0WU
KARPAS-45 NYXxbZl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHpc4JKSzVyPUCuN|c{OjFizszN MV\TRW5ITVJ?
NCI-H720 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDzTWM2OD1yLkO3Olc6KM7:TR?= M1faenNCVkeHUh?=
H9 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLLcWt7UUN3ME2wMlM5QDh|IN88US=> NYjP[mpXW0GQR1XS
EFM-19 NF7yfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M163fGlEPTB;MD60OFAyKM7:TR?= M4jvXXNCVkeHUh?=
SBC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfxUGhHUUN3ME2wMlQ1ODN3IN88US=> M2rGPXNCVkeHUh?=
A4-Fuk MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNE[4Olgh|ryP NWDpU4o3W0GQR1XS
NCI-H1563 NVzRPJByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHtdHpEUUN3ME2wMlQ5OTh7IN88US=> NEnQU4NUSU6JRWK=
HCC1419 NWLtPGJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHBRlBEUUN3ME2wMlQ5QDl{IN88US=> MXzTRW5ITVJ?
H-EMC-SS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PORmlEPTB;MD60PVk{QSEQvF2= MVLTRW5ITVJ?
BHT-101 M1\3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LCNmlEPTB;MD61Nlk3OSEQvF2= MUHTRW5ITVJ?
IGROV-1 NXjleJFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TCTmlEPTB;MD61OVI1QSEQvF2= MYfTRW5ITVJ?
HGC-27 NUfzNIRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHVb4g6UUN3ME2wMlU3Pzh|IN88US=> NXuxO3A{W0GQR1XS
MDA-MB-361 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNUe3OlEh|ryP NV;pclVZW0GQR1XS
KE-37 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33SR2lEPTB;MD61PFI3KM7:TR?= NFjoWZpUSU6JRWK=
HCC70 NEixSHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvtOnRTUUN3ME2wMlU6QDJ5IN88US=> MYXTRW5ITVJ?
LNCaP-Clone-FGC Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjFe5ZHUUN3ME2wMlYyODR6IN88US=> M17hUnNCVkeHUh?=
HAL-01 M1LG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi2cWFiUUN3ME2wMlYzOTNizszN MmrhV2FPT0WU
HT MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfKbJF2UUN3ME2wMlY{OjN7IN88US=> NW\PO|Q6W0GQR1XS
MDA-MB-415 NGLoUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwNkO2NlYh|ryP NFHLNIFUSU6JRWK=
NOS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGyTWM2OD1yLk[zO|I{KM7:TR?= NVToRWoyW0GQR1XS
DU-145 NH3kd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNkS3OFUh|ryP MmDRV2FPT0WU
OCUB-M MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwN{C5OlYh|ryP NEHkOFBUSU6JRWK=
VA-ES-BJ Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHiTWM2OD1yLkezNFI2KM7:TR?= MY\TRW5ITVJ?
J-RT3-T3-5 NEPje2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M121dGlEPTB;MD63OFQxOyEQvF2= NYXiXoFrW0GQR1XS
MOLT-4 NIDNXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:0e2lEPTB;MD64NFU5OiEQvF2= M2T2RnNCVkeHUh?=
NB7 NIfpTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDNc2VKSzVyPUCuPFI1OTFizszN MmTmV2FPT0WU
L-363 NWTEc2hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwOEO0OFIh|ryP MUTTRW5ITVJ?
NKM-1 NVH5S5hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITxSWNKSzVyPUCuPFYzPTNizszN MX\TRW5ITVJ?
HOP-92 M3yzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwOEeyNlMh|ryP Ml7GV2FPT0WU
OAW-42 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\5ZolKSzVyPUCuPFg4OiEQvF2= NEDOTnpUSU6JRWK=
HuO9 M3L4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELxc|NKSzVyPUCuPVI4PTFizszN NV3oZXFsW0GQR1XS
MFE-280 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fSbmlEPTB;MD65OlQ3PSEQvF2= MWHTRW5ITVJ?
EM-2 NFzRenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LlbWlEPTB;MD65O|k{QSEQvF2= NYHBRWRqW0GQR1XS
NCI-H520 NHjUNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13FXWlEPTB;MD65PFU6OiEQvF2= NXH0U3h6W0GQR1XS
LB2241-RCC M33JZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;BWphKSzVyPUCuPVk4OzRizszN MljzV2FPT0WU
SK-NEP-1 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rKbGlEPTB;MT6xOFQ5PSEQvF2= M1vONHNCVkeHUh?=
LXF-289 NGrVV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofhTWM2OD1zLkG3NVU3KM7:TR?= NVP6UpRQW0GQR1XS
EPLC-272H NETXZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDwd5ZKSzVyPUGuNVczPTZizszN NUXrNFl3W0GQR1XS
COLO-684 NGjRPYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXjNnU3UUN3ME2xMlI{PzJ3IN88US=> MWfTRW5ITVJ?
ES1 NVTT[2VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nmSGlEPTB;MT6yOFA3PSEQvF2= MofiV2FPT0WU
DOHH-2 NGrqbVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWwdVA6UUN3ME2xMlI5OjB|IN88US=> NE\ve49USU6JRWK=
CTB-1 MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHSOJZKSzVyPUGuNlg6QSEQvF2= NVW4VJprW0GQR1XS
G-401 NXTWR2U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\QSWlEPTB;MT6yPVc6PSEQvF2= NELKRndUSU6JRWK=
LoVo M{jqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwM{K1N|Qh|ryP M2joOnNCVkeHUh?=
Ramos-2G6-4C10 NWm0eoJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTFwM{O3NFEh|ryP M3PINnNCVkeHUh?=
MFM-223 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrxVXhtUUN3ME2xMlM1PDZzIN88US=> M4PubXNCVkeHUh?=
PA-1 NELrR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFwM{WyOlUh|ryP Mnz2V2FPT0WU
697 NHvSWGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKfFN5UUN3ME2xMlM4PjF4IN88US=> NEX6NpVUSU6JRWK=
QIMR-WIL MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvCWXJKSzVyPUGuOFkyOTZizszN M2G5O3NCVkeHUh?=
HOS M2TiZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHQXFVKSzVyPUGuOFk2PThizszN M1LjXXNCVkeHUh?=
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ME-180 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwNU[4PVEh|ryP MV\TRW5ITVJ?
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CAL-54 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFwN{GyOFIh|ryP M1rpT3NCVkeHUh?=
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MN-60 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfkem05UUN3ME2yMlI6QTJ|IN88US=> MYPTRW5ITVJ?
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D-423MG M1GyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDkO2p3UUN3ME2yMlQyODR2IN88US=> MYXTRW5ITVJ?
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EW-3 MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3LTWM2OD1|LkG5OVI6KM7:TR?= MlXTV2FPT0WU
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OVCAR-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXidmlkUUN3ME2zMlQxPzh4IN88US=> MXXTRW5ITVJ?
NCI-H1623 NUPHcmxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWWybpBEUUN3ME2zMlQyOjJ2IN88US=> M3PiZnNCVkeHUh?=
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LU-134-A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvtVWdKSzVyPUOuPFg1OjhizszN MlezV2FPT0WU
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SCC-25 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV70WmtIUUN3ME20MlA3PTZ4IN88US=> MkLYV2FPT0WU
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LAMA-84 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTRwMUSxPVEh|ryP M3;OPXNCVkeHUh?=
Calu-3 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTRwMkS0NVYh|ryP M2XxdXNCVkeHUh?=
NCI-H460 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\Wd2dJUUN3ME20MlI3PDR|IN88US=> NXzkWZBxW0GQR1XS
EGI-1 M4DEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iyU2lEPTB;ND6zO|c4QCEQvF2= MUDTRW5ITVJ?
NCI-H292 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu4TWM2OD12LkO4NVQ3KM7:TR?= MYfTRW5ITVJ?
HCE-T NGrsfXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3znSWlEPTB;ND60NVU4QSEQvF2= MkPNV2FPT0WU
EW-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnxTWM2OD12LkSxPFM5KM7:TR?= MkfRV2FPT0WU
ATN-1 NET3PIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;RcZAzUUN3ME20MlQ1OzB2IN88US=> NW\td|B5W0GQR1XS
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KLE MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\tTWM2OD12LkewNVk5KM7:TR?= MYjTRW5ITVJ?
CAL-39 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO4VZFyUUN3ME20MlczOTR4IN88US=> NH;yPYhUSU6JRWK=
TI-73 NWXaXYVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHhTmM5UUN3ME20MlgxPjB7IN88US=> M1rGWHNCVkeHUh?=
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786-0 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwOUS2O|Mh|ryP MmHoV2FPT0WU
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NCI-H446 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;0TWM2OD13LkKwNFA6KM7:TR?= NEHobnBUSU6JRWK=
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BT-20 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITEbpRKSzVyPUWuNlE{PTNizszN MXTTRW5ITVJ?
MEL-HO MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LrUWlEPTB;NT6zO|M{PiEQvF2= NEDoT4FUSU6JRWK=
CAL-27 M2fTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOzRXVKSzVyPUWuOFY{OzlizszN M{myeHNCVkeHUh?=
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RPMI-2650 NGLrN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTVwNk[xPVkh|ryP MnPJV2FPT0WU
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SK-OV-3 NGrHW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTVwOUm4NVYh|ryP Mn61V2FPT0WU
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BFTC-909 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nxRWlEPTB;Nj6zNFM1PSEQvF2= M{K2UXNCVkeHUh?=
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TE-12 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn25TWM2OD14LkizPFE4KM7:TR?= NGDIN|VUSU6JRWK=
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SW1463 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H1cGlEPTB;Nz6xNVE3QCEQvF2= M2jS[HNCVkeHUh?=
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MC-IXC NH72UpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzXTWM2OD15LkS4OVc3KM7:TR?= M2DiPHNCVkeHUh?=
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CAL-33 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y1SWlEPTB;Nz62OlI{OyEQvF2= M4jUPXNCVkeHUh?=
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D-566MG NH;RcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRThwMES0Nlkh|ryP MVTTRW5ITVJ?
JVM-3 NVT2NHBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjNV3E{UUN3ME24MlE2OjZ6IN88US=> MWnTRW5ITVJ?
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HCC1954 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS1RWdKSzVyPUiuOFUyODRizszN MWXTRW5ITVJ?
SF126 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XwdWlEPTB;OD60OVk{PiEQvF2= M4DjcHNCVkeHUh?=
LB996-RCC NHXsflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HOS2lEPTB;OD61N|I2PyEQvF2= MXnTRW5ITVJ?
SKG-IIIa MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PiNWlEPTB;OD62N|A3QSEQvF2= NXjtdnZDW0GQR1XS
NCI-SNU-1 Mly2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRThwNkS2OFMh|ryP MYfTRW5ITVJ?
LB771-HNC M{D5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS3bJVKSzVyPUiuOlQ3QTZizszN NVnUT|c6W0GQR1XS
SCC-4 MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTYTWM2OD16Lk[4NlE6KM7:TR?= MUPTRW5ITVJ?
CAMA-1 NIPZcJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRThwN{exOFYh|ryP MWHTRW5ITVJ?
D-502MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzGcYhGUUN3ME24Mlc5PjJ7IN88US=> NUjmeG9zW0GQR1XS
ESS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4myUWlEPTB;OD64PFcxPCEQvF2= NGfJcpJUSU6JRWK=
HEC-1 NXi0NXR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRThwOEm4OlYh|ryP M3;tT3NCVkeHUh?=
NB10 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTlwMEKyNlQh|ryP Mm\6V2FPT0WU
8505C NIfrO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEeyV4FKSzVyPUmuNFQzOzJizszN NIXZfVBUSU6JRWK=
EFO-27 M4[4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL6TWM2OD17LkG2OFEzKM7:TR?= Mn7xV2FPT0WU
HN NFjrVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfuO5B5UUN3ME25MlE3PjJ6IN88US=> M4rDdXNCVkeHUh?=
DSH1 M2HqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy4Oo9GUUN3ME25MlIxQDdizszN NGPn[JdUSU6JRWK=
NBsusSR NVzOfZRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTlwMke0NFIh|ryP M2K2fXNCVkeHUh?=
LS-123 NG\Qd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInNUnFKSzVyPUmuN|E4PjFizszN Mn3zV2FPT0WU
SHP-77 M1fBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i1cWlEPTB;OT6zPVk{PSEQvF2= MlXPV2FPT0WU
ACN M3LvSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\jd2lEUUN3ME25MlU{Ojd5IN88US=> MV7TRW5ITVJ?
U251 NEXrNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n6b2lEPTB;OT62OVU1PCEQvF2= NGK2T2NUSU6JRWK=
A431 MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW5TWM2OD17LkiwNlM5KM7:TR?= MXjTRW5ITVJ?
5637 NUPLVmhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\vTWM2OD17Lki0PVg1KM7:TR?= NGCy[IRUSU6JRWK=
MDA-MB-157 NFfjeoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1fWJKSzVyPUmuPVI5PzhizszN NHO2Um5USU6JRWK=
A101D NGD6T2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\GOGlEPTB;OT65PVk4PCEQvF2= MX3TRW5ITVJ?
YKG-1 M4LUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fU[GlEPTB;MUCuNlAxPiEQvF2= Ml3EV2FPT0WU
LAN-6 M2TyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFyLkKxOlQh|ryP MlHZV2FPT0WU
OVCAR-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFyLkK0N|Mh|ryP MYfTRW5ITVJ?
A549 M1fJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrzTWM2OD1zMD6zPVc{KM7:TR?= MX\TRW5ITVJ?
no-11 NVnHbG8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n2U2lEPTB;MUCuOFM2OyEQvF2= MkHoV2FPT0WU
SF539 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS3NW5lUUN3ME2xNE46ODRzIN88US=> M{ftRXNCVkeHUh?=
A388 NVrjd3dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojLTWM2OD1zMT6zPFk4KM7:TR?= NH65d5lUSU6JRWK=
DEL NIX5Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPZfld4UUN3ME2xNU41OjRizszN NHnaZ41USU6JRWK=
SW954 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofzTWM2OD1zMT60OlY5KM7:TR?= NUG1bI5EW0GQR1XS
TK10 MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnNZ2lXUUN3ME2xNU42OjdzIN88US=> MWfTRW5ITVJ?
SW756 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX2OohKSzVyPUGxMlUzQTRizszN MW\TRW5ITVJ?
PC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4KwXmlEPTB;MUGuOVc3PCEQvF2= MlXlV2FPT0WU
ONS-76 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln1TWM2OD1zMT62N|Yh|ryP NYjCdVZ2W0GQR1XS
A427 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTjdlhFUUN3ME2xNU44ODl|IN88US=> NFvQc3VUSU6JRWK=
MEG-01 NYPqPVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLlOoVVUUN3ME2xNU44PTB7IN88US=> MnPKV2FPT0WU
BB30-HNC M2CwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\hXplKSzVyPUGxMlc6QDJizszN M2TReXNCVkeHUh?=
NCI-H1299 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFzLkiwPVMh|ryP M2jvd3NCVkeHUh?=
GCT M2XOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFzLkiyNlgh|ryP MX3TRW5ITVJ?
D-247MG MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFzLkm2OlMh|ryP NGHvXoZUSU6JRWK=
CFPAC-1 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL1TWM2OD1zMT65O|gzKM7:TR?= M2nFeXNCVkeHUh?=
EKVX MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnGclZ{UUN3ME2xNk4xOzF|IN88US=> NHSzbnZUSU6JRWK=
CAL-51 M1zvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITib3BKSzVyPUGyMlA4OTZizszN MXrTRW5ITVJ?
BB49-HNC NWrQPGhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLOeI5lUUN3ME2xNk4yOTd5IN88US=> M1LoNnNCVkeHUh?=
RPMI-7951 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF{LkG4OVQh|ryP NInTZWdUSU6JRWK=
RH-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjBTGdKSzVyPUGyMlIyQDRizszN MYHTRW5ITVJ?
BCPAP MoW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF{LkS3OFkh|ryP NHiwRmhUSU6JRWK=
GCIY Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDDdZl2UUN3ME2xNk42OjB7IN88US=> MUfTRW5ITVJ?
KNS-81-FD MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF{LkW4Olkh|ryP MnyzV2FPT0WU
KYSE-140 NHOyZ|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzWZZRJUUN3ME2xNk45PTl3IN88US=> NVGyc5gyW0GQR1XS
Ca-Ski MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHndHlwUUN3ME2xNk46ODRzIN88US=> M3nlZ3NCVkeHUh?=
TGBC1TKB M2G5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm4[HMzUUN3ME2xNk46OTF3IN88US=> NVvE[o81W0GQR1XS
HCC1187 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK0dWlHUUN3ME2xN{4yQTF{IN88US=> M{KySnNCVkeHUh?=
SJSA-1 MnPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXwfnNxUUN3ME2xN{4zOzJ5IN88US=> M2T4O3NCVkeHUh?=
CTV-1 NVzBRVJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP0[XR[UUN3ME2xN{4{PDVizszN NXrpV4k5W0GQR1XS
WM-115 M2\iZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy4bYNKSzVyPUGzMlY1QDNizszN MW\TRW5ITVJ?
CHP-212 NWfO[4JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTONZhSUUN3ME2xN{46PzN7IN88US=> MWfTRW5ITVJ?
SCC-15 NXKyb215T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlftTWM2OD1zMz65O|c2KM7:TR?= MYjTRW5ITVJ?
BPH-1 NXrEdmpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zyVGlEPTB;MUSuNVY3PCEQvF2= NEHTOYxUSU6JRWK=
SW780 NIDQeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jXZWlEPTB;MUSuOVAzPSEQvF2= MXHTRW5ITVJ?
NCI-H2291 NH\YSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:wOFBKSzVyPUG0MlU5PzhizszN NULmfoFEW0GQR1XS
JEG-3 NV3lcXlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zYNWlEPTB;MUSuOlMzPiEQvF2= MVXTRW5ITVJ?
CAL-120 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF2LkewNlch|ryP MVrTRW5ITVJ?
NCI-H23 NU[yTHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF2Lke5PVch|ryP M3nCfXNCVkeHUh?=
MS-1 NEHwbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrRd5dDUUN3ME2xOE46PjFzIN88US=> M1:xRXNCVkeHUh?=
PC-14 NULBZZhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PjNGlEPTB;MUSuPVY2PCEQvF2= NYDKXFZtW0GQR1XS
D-283MED MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHyTWM2OD1zNT6wNVEyKM7:TR?= NEDZZZJUSU6JRWK=
OE19 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjh[4dKSzVyPUG1MlE2PDFizszN M2PzU3NCVkeHUh?=
CAS-1 M1zHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF3LkSxPFQh|ryP MnjuV2FPT0WU
NCI-H727 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvQTWM2OD1zNT60NlIyKM7:TR?= NWKxTop6W0GQR1XS
SiHa MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3mTWM2OD1zNT63OVk1KM7:TR?= MlnLV2FPT0WU
BFTC-905 NEnoNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF3Lke2PVQh|ryP MljEV2FPT0WU
MDA-MB-453 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rEWGlEPTB;MU[uNVY1OiEQvF2= Ml;IV2FPT0WU
HuP-T3 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF4Lk[zO|Mh|ryP NFOxVIJUSU6JRWK=
SK-LU-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;re2lEPTB;MU[uOlk2PiEQvF2= M3TRXnNCVkeHUh?=
Detroit562 M{L0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r3[2lEPTB;MU[uO|MyQCEQvF2= MWnTRW5ITVJ?
HCC1569 NVjlboxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Hl[2lEPTB;MU[uPFM{PyEQvF2= NVzKRmw{W0GQR1XS
SK-MES-1 M{CxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\NVHdKSzVyPUG2Mlg1OTlizszN NUX3cZMyW0GQR1XS
BB65-RCC NXHWN4VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu1c2JKSzVyPUG3MlA1PzlizszN MlzKV2FPT0WU
LOXIMVI MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf4TWM2OD1zNz6wO|A4KM7:TR?= MUnTRW5ITVJ?
SW1783 MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF5LkGyPEDPxE1? NEHsT3BUSU6JRWK=
NH-12 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\MNFFKSzVyPUG3MlM{ODNizszN Mnf0V2FPT0WU
UACC-257 NYPYbXlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv6V3ZYUUN3ME2xO{42PTF{IN88US=> MUPTRW5ITVJ?
KOSC-2 NGXydmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vvU2lEPTB;MUeuOlc2PyEQvF2= MmnYV2FPT0WU
KG-1 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzaTWM2OD1zNz62PVM4KM7:TR?= MnuyV2FPT0WU
M059J NHHSdJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULucFJNUUN3ME2xO{44ODNizszN M2nHR3NCVkeHUh?=
MHH-NB-11 MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC5OJdKSzVyPUG3Mlk3PzNizszN NGrJNnlUSU6JRWK=
EW-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHTTWM2OD1zOD6xN|gzKM7:TR?= NGPGbnJUSU6JRWK=
CAL-85-1 NVr2WYFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF6LkKzOVch|ryP MXrTRW5ITVJ?
639-V Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnsSmZKSzVyPUG4MlM{PTRizszN NI[2dJVUSU6JRWK=
C32 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF6LkS3Nlch|ryP NHrobFFUSU6JRWK=
KM-H2 MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom0TWM2OD1zOD61NlMzKM7:TR?= Ml[3V2FPT0WU
A253 NH7CXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1joW2lEPTB;MUiuO|I5PiEQvF2= MmHoV2FPT0WU
NCI-N87 NGi2S4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTF6LkmwNFgh|ryP NVK2cFF6W0GQR1XS
8-MG-BA M33mfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjoTXpWUUN3ME2xPU4xPjR4IN88US=> NGnBd5ZUSU6JRWK=
GI-ME-N MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLSemdKSzVyPUG5MlE2PDZizszN MV3TRW5ITVJ?
8305C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS1OWJKSzVyPUG5MlIzQDZizszN NUL2b5ZVW0GQR1XS
TE-8 NFKxbm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzGTWM2OD1zOT6zNFI1KM7:TR?= NHvDVJNUSU6JRWK=
KYSE-270 NX\rPIVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOwOYdOUUN3ME2yNE4xOjF5IN88US=> NFrkVopUSU6JRWK=
HL-60 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJyLkC5OFEh|ryP NGXoXG9USU6JRWK=
Mo-T M3vR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJyLkG2OlUh|ryP MYHTRW5ITVJ?
NCI-H1355 NUn0cXYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v0WmlEPTB;MkCuN|M4PCEQvF2= MnrlV2FPT0WU
HT-1080 M325Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJyLkW0PVch|ryP M3vBbXNCVkeHUh?=
MIA-PaCa-2 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJyLk[4PFMh|ryP NUX6cYNZW0GQR1XS
NCI-H441 NF\HU|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojHTWM2OD1{MD63N|c6KM7:TR?= MoX4V2FPT0WU
LCLC-97TM1 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH0TWM2OD1{MD64NVM1KM7:TR?= MlrXV2FPT0WU
HT-3 M2i4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJzLkW2N|Eh|ryP NH\hU29USU6JRWK=
22RV1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjnVW9SUUN3ME2yNU42Pjh3IN88US=> MV\TRW5ITVJ?
LK-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfzZ41sUUN3ME2yNU42QTV|IN88US=> MWPTRW5ITVJ?
CW-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TFcGlEPTB;MkGuOlA3QSEQvF2= MoLSV2FPT0WU
KYSE-510 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2noNmlEPTB;MkGuOlA6PSEQvF2= NWXDNmkyW0GQR1XS
CGTH-W-1 NWO1clhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfWUZdKSzVyPUKxMlcyPjZizszN M{O1d3NCVkeHUh?=
NCI-H661 NV3kNnhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJ{LkCzOEDPxE1? MnLhV2FPT0WU
KU-19-19 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vXU2lEPTB;MkKuNVY6PyEQvF2= NEDnU2ZUSU6JRWK=
NCI-H2122 M1jqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XHPGlEPTB;MkKuNlQ{OiEQvF2= MorGV2FPT0WU
NCI-H526 NVLHeZN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jScWlEPTB;MkKuN|g6PSEQvF2= NUPGbo5pW0GQR1XS
NCI-H1650 NWLD[VZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWzTWM2OD1{Mj63OlQh|ryP MkLqV2FPT0WU
AM-38 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LYNGlEPTB;MkKuPFY5QSEQvF2= M1LROHNCVkeHUh?=
NCI-H2405 M3jKdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj3N2lKSzVyPUKzMlI2OzNizszN MYTTRW5ITVJ?
M14 NXGxcWNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LmfGlEPTB;MkOuOFA5QCEQvF2= M1G3SnNCVkeHUh?=
ES4 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnRRpRNUUN3ME2yN{41OjN{IN88US=> NXTIR4NVW0GQR1XS
DJM-1 NGThVo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:4UWhkUUN3ME2yN{42OjN2IN88US=> M32yb3NCVkeHUh?=
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DoTc2-4510 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PYOWlEPTB;OESuNlE5PSEQvF2= M2ixNnNCVkeHUh?=
NCI-H1581 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG3PHh{UUN3ME24OU41PjRzIN88US=> MXLTRW5ITVJ?
KARPAS-299 NUDWfHFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHXbldKSzVyPUi2MlE6PzdizszN MYHTRW5ITVJ?
IST-MEL1 NGG0XWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrrZ45jUUN3ME24Ok45QDd{IN88US=> MV3TRW5ITVJ?
KP-N-YS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnuTWM2OD16OT65NFI5KM7:TR?= MoTuV2FPT0WU
KYSE-410 M4DCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHxTWM2OD17MT60NFQzKM7:TR?= NID0R|dUSU6JRWK=
TE-10 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTlzLkW2NVEh|ryP NHnzWHlUSU6JRWK=
SK-MEL-1 NWfabmlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PjRWlEPTB;OUKuPVExPiEQvF2= NUfTd49[W0GQR1XS
COLO-792 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjPUIVPUUN3ME25OU4zPTZ2IN88US=> NEPMPVZUSU6JRWK=
SCH NF7EWo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLneWNPUUN3ME25Ok4{QDd5IN88US=> Mk\mV2FPT0WU
NCI-H1792 NGDpepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjVcpFoUUN3ME25Ok45QTl{IN88US=> MUnTRW5ITVJ?
NCI-H2029 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHoTWM2OD17Nj65OVY3KM7:TR?= NFT0No1USU6JRWK=
SW684 M1PQbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DLUmlEPTB;OUiuOlY2PCEQvF2= MVzTRW5ITVJ?
NCI-H209 M4D4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFyMD6xNlEh|ryP M3[yeXNCVkeHUh?=
HLE NX;NeINTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFyNT6yPFIh|ryP M3[5PHNCVkeHUh?=
GOTO NYnDfW9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OxeWlEPTB;MUC3Mlc4PyEQvF2= NYDoZXpmW0GQR1XS
NCI-H1793 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz3ZlZKSzVyPUGwPU4zQCEQvF2= MWnTRW5ITVJ?
D-392MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P3VGlEPTB;MUG3MlM6QCEQvF2= M{LXdnNCVkeHUh?=
SW1990 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\6VGlEPTB;MUKwMlk2OSEQvF2= NHzsTXpUSU6JRWK=
ML-2 NEDVUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX61clh{UUN3ME2xNlEvPjd4IN88US=> NEPoV3pUSU6JRWK=
NCI-H2452 NVLySWxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDyTWM2OD1zMkKuNlEh|ryP M2PIZ3NCVkeHUh?=
SK-MEL-30 NEHWfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHu[29lUUN3ME2xNlMvOjR2IN88US=> MU\TRW5ITVJ?
SN12C M{m0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\0WWlEPTB;MUK0MlE4PiEQvF2= MYPTRW5ITVJ?
NCI-H1770 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rm[mlEPTB;MUK1MlUyPCEQvF2= NEPRUndUSU6JRWK=
SF268 NIHk[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF{Nj6xOVgh|ryP NFfjfGtUSU6JRWK=
BALL-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHmTWM2OD1zMk[uNlMh|ryP MVjTRW5ITVJ?
COLO-679 MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKzTWM2OD1zMk[uO|U{KM7:TR?= MkXpV2FPT0WU
A2780 M1j1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3XeJJKSzVyPUGyPE46QDhizszN MWDTRW5ITVJ?
NCI-H1651 NGDPWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70UGdKSzVyPUGzNU4zPDNizszN MoKzV2FPT0WU
NCI-H2087 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj6TWM2OD1zM{GuOFg{KM7:TR?= NHTCTVhUSU6JRWK=
U-87-MG M4W0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vNSmlEPTB;MUOzMlYxPCEQvF2= MWXTRW5ITVJ?
LB2518-MEL Mm\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF|NT65PVMh|ryP M{izNHNCVkeHUh?=
HCT-116 NUXjc4h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH3bIVKSzVyPUGzO{4zOTdizszN MlLSV2FPT0WU
Ca9-22 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF|OT64N|Mh|ryP MUPTRW5ITVJ?
COR-L88 NFT0c4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LiSmlEPTB;MUSyMlE1KM7:TR?= MmTKV2FPT0WU
CP50-MEL-B NWPiZmtqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xte2lEPTB;MUS0MlUxOSEQvF2= MVLTRW5ITVJ?
OVCAR-8 NHzCZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfGeHZEUUN3ME2xOFUvPjN4IN88US=> M3jzW3NCVkeHUh?=
SK-MEL-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF2Nz64O|gh|ryP MVfTRW5ITVJ?
GT3TKB MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHuboI4UUN3ME2xOFkvQTJ6IN88US=> NXvUOYNJW0GQR1XS
KYSE-450 M{\zZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTF3MT61N|kh|ryP M1yxfnNCVkeHUh?=
CAPAN-1 NUnYVoc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnMfo1JUUN3ME2xOVMvODZ2IN88US=> NWnvS2dUW0GQR1XS
BEN MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nQVGlEPTB;MUWzMlkzQCEQvF2= NIfaVlNUSU6JRWK=
NCI-H1304 NFz3b5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF3ND62PVQh|ryP MWLTRW5ITVJ?
KU812 NXjpNW1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PIWmlEPTB;MUW4MlY4PCEQvF2= MYjTRW5ITVJ?
Capan-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK0TWM2OD1zNkCuOVU{KM7:TR?= MX7TRW5ITVJ?
A673 NHvPcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[2dmlEPTB;MU[xMlcxPSEQvF2= MofMV2FPT0WU
SAS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PVVmlEPTB;MU[yMlY4QCEQvF2= MWDTRW5ITVJ?
NY NF3GfG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ThVWlEPTB;MU[1MlMyPCEQvF2= MYrTRW5ITVJ?
HCE-4 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXPSWdKSzVyPUG2Ok45PDVizszN MkHZV2FPT0WU
MDA-MB-231 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPoTWM2OD1zN{euOVA{KM7:TR?= NF3RcGhUSU6JRWK=
no-10 NXfiNpI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3ZPVFVUUN3ME2xO|gvOTN2IN88US=> NInoXWZUSU6JRWK=
MZ7-mel MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj0OYU1UUN3ME2xO|gvPDZ5IN88US=> NHvjWGJUSU6JRWK=
NCI-H82 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j5fmlEPTB;MUiwMlE3PSEQvF2= MmLLV2FPT0WU
CAL-72 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHMOmtzUUN3ME2xPFUvODV2IN88US=> M130bnNCVkeHUh?=
NCI-SNU-5 Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfrTWM2OD1zOE[uPFQh|ryP NILod5dUSU6JRWK=
OVCAR-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\MSXJYUUN3ME2xPFgvOzN|IN88US=> Mn\4V2FPT0WU
SCC-9 M2Lib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF7MTFOwG0> MkPyV2FPT0WU
KYSE-150 M1GxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL4TWM2OD1zOUGuPFg5KM7:TR?= NYrWXllMW0GQR1XS
HT-29 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e1UmlEPTB;MkCxMlIyOiEQvF2= MYTTRW5ITVJ?
COLO-678 M3LZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJyMT60OUDPxE1? NX74dJpxW0GQR1XS
NCI-H650 NITOcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHKN5hvUUN3ME2yNFIvOTB|IN88US=> M{XyRnNCVkeHUh?=
HuCCT1 M1;DPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJyND6yNFgh|ryP MmrBV2FPT0WU
SW1116 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[3TWM2OD1{MEeuNFc4KM7:TR?= NFjpPZRUSU6JRWK=
DBTRG-05MG MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPS[JJKSzVyPUKwO{46ODlizszN MkGxV2FPT0WU
SW982 NH;RdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\rTWM2OD1{MEeuPVQ5KM7:TR?= M3\vcXNCVkeHUh?=
RCM-1 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD1{MUSuO|YzKM7:TR?= NYHCNnBHW0GQR1XS
COLO-320-HSR M3vhfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz3[|VKSzVyPUKxOk4yOjVizszN M4HVbnNCVkeHUh?=
KNS-42 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTpTWM2OD1{MU[uOVc1KM7:TR?= NYW4Um5GW0GQR1XS
C2BBe1 NEnyOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DpZ2lEPTB;MkOxMlkxPSEQvF2= MorTV2FPT0WU
CCRF-CEM M3\WdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j2e2lEPTB;MkSzMlc6PSEQvF2= NEjuWZVUSU6JRWK=
SH-4 NVqxZXlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHTZ2lKSzVyPUK0Ok4xQSEQvF2= MYLTRW5ITVJ?
LS-1034 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DIbWlEPTB;MkS2MlI3PiEQvF2= Mnm5V2FPT0WU
NCI-H2347 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnHclZVUUN3ME2yOFcvPzF|IN88US=> M170NHNCVkeHUh?=
RPMI-8866 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LrSmlEPTB;MkS5MlI4KM7:TR?= MULTRW5ITVJ?
GAK NIjBSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnmcXJ[UUN3ME2yOVMvODB{IN88US=> NFnM[lRUSU6JRWK=
NB6 NGfXZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCwTWM2OD1{N{CuNUDPxE1? MkXNV2FPT0WU
COLO-680N M{PZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW0TWM2OD1{N{KuOVI4KM7:TR?= NYn0[FRVW0GQR1XS
RERF-LC-MS Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHMTWM2OD1{N{[uNFA4KM7:TR?= MoHEV2FPT0WU
TGBC11TKB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rDT2lEPTB;Mke4MlE4QCEQvF2= NETWN49USU6JRWK=
C8166 NX3XZ4lWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrnTWM2OD1{N{iuOVA3KM7:TR?= NG\5V3hUSU6JRWK=
HDLM-2 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2xTWM2OD1{OUSuOFA6KM7:TR?= M362cnNCVkeHUh?=
IGR-1 NHv6VINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ7NT62OVkh|ryP M3LEe3NCVkeHUh?=
FADU NEDZRWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJ7Nz61NUDPxE1? NEPh[WVUSU6JRWK=
L-428 NF3MT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjkRolKSzVyPUK5O{43OTZizszN M4\yXnNCVkeHUh?=
LU-65 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[5OIJpUUN3ME2zNFQvOzJizszN NIXweWFUSU6JRWK=
HEL NUjoeJpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TLSWlEPTB;M{C5Mlk5OyEQvF2= NEHlfZVUSU6JRWK=
NCI-H810 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzLfnpHUUN3ME2zNVAvPTdizszN MlrzV2FPT0WU
C3A MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[1[FZKSzVyPUOxNU45ODJizszN M4D4OXNCVkeHUh?=
NCI-H630 NILWfZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn33TWM2OD1|M{KuNlk1KM7:TR?= MojHV2FPT0WU
KP-N-YN NXHQUoVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX22V5l[UUN3ME2zOFEvOTJ|IN88US=> NX;uT41sW0GQR1XS
MOLT-13 NXTlbmNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLlVnpKSzVyPUO0Nk4{OjZizszN MVLTRW5ITVJ?
NCI-H1993 NIPYeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n3UWlEPTB;M{SyMlM3PSEQvF2= NIq0O2lUSU6JRWK=
BE-13 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOzTWM2OD1|NESuNVY4KM7:TR?= M{\QOnNCVkeHUh?=
IST-SL1 NVTiXmlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTrb3JoUUN3ME2zOFcvPDBzIN88US=> MXjTRW5ITVJ?
TE-9 M{LMNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTN4Mz61PFkh|ryP NXvZV5gyW0GQR1XS
LU-135 NFruVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UU2pKSzVyPUO2O{4xOzVizszN MoH0V2FPT0WU
T84 M2\iW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL1OpNKSzVyPUO3OE44OTJizszN NHXkTFNUSU6JRWK=
K-562 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33HXGlEPTB;M{izMlM3KM7:TR?= NUOxe25DW0GQR1XS
SBC-5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj5UFBKSzVyPUO4Ok46QDVizszN MX\TRW5ITVJ?
NB17 M2nxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN7Mj61PVYh|ryP M3e5cXNCVkeHUh?=
NCI-H2052 NH3CNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LO[WlEPTB;M{m4MlQ4OiEQvF2= NFf2T3VUSU6JRWK=
HCC38 NH\VT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\mTWM2OD12MEGuOVk{KM7:TR?= NHHzNpdUSU6JRWK=
NCI-H69 M2HGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;xTWM2OD12NEGuNFg{KM7:TR?= M1TqXHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

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Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

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  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Formulation: Formulated in 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID