MK-2206 2HCl

Catalog No.S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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Cited by 916 Publications

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NHvZNI5EgXSxdH;4bYMhSXO|YYm= M4C2[|Mh|ryP M1L2VVczKGh? MnXqSG1UVw>? NInJSHZKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= M1LNN|IxPTdzME[5
A431 M3T3NGtqdmG|ZTDBd5NigQ>? NV7sS2p3PSEQvF2= NGLabXU2KGh? MYXEUXNQ M4LNZ3N2eHC{ZYPz[ZMhfGinIIPp[45idGmwZzDv[kBCc3RiYX7kJGVzcw>? NVTybZNKOjB3N{GwOlk>
HepG2 M4m4RmN6fG:2b4jpZ{BCe3OjeR?= NYr4bFRTOTBizszN M4PMW|I1KGh? MWDEUXNQ MVnT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= NIrJUYwzOTJyNUmyOS=>
Sk-Hep1 NGT5fYhEgXSxdH;4bYMhSXO|YYm= NYTZd2J6OTBizszN MmHCNlQhcA>? NYrZ[mlJTE2VTx?= NYLsd|N7W2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj MYGyNVIxPTl{NR?=
OCUT1 cells harbored PIK3CA (H1047R+/+) MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWOzJO69VQ>? NX60PWxlPSCm NVP0OFBPTE2VTx?= M{HLW2lEPTB;MD6xOEDPxE1? NH7wOIMzOTJ6OUK2Oy=>
K1 cells harbored PIK3CA (E542K+/+) MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TR[FMh|ryP MnPGOUBl MlfOSG1UVw>? MV\JR|UxRTBwNUKg{txO NEPJR2EzOTJ6OUK2Oy=>
FTC133 cells harbored PTEN (allele deletion and R130+) MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLkXYVTOyEQvF2= NWX6bG43PSCm MorSSG1UVw>? NF[5V2RKSzVyPUCuNVgh|ryP MmjZNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) M4ryT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrEfY9wOyEQvF2= NIfOdIM2KGR? NGTacZNFVVOR NEjnTo9KSzVyPUCuNlch|ryP M3H2eVIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) M4C3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nn[VMh|ryP MoXNOUBl M3PvNWROW09? NVPYS5NCUUN3ME20MlUh|ryP NH3Jb5ozOTJ6OUK2Oy=>
TPC1 cells harbored RET/PTC1 rearrangement MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jCZ|Mh|ryP NGrSV3I2KGR? M3LYOGROW09? NWT5UYNpUUN3ME2wMlU6KM7:TR?= MoW5NlEzQDl{Nke=
Hth74 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP5[4M{KM7:TR?= NYrGXZFlPSCm M1XEUGROW09? NIrydYtKSzVyPUKuNVkh|ryP NXqwO2FYOjF{OEmyOlc>
KAT18 NF7hOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnIPIQyOyEQvF2= MYe1JIQ> M4Kze2ROW09? NYPwUIhMUUN3ME20MlYzKM7:TR?= NXHIbW1QOjF{OEmyOlc>
SW1736 NIP2XYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XJWVExOCEQvF2= NIW5NVk2KGR? MUjEUXNQ M4G0PGlEPTB;NEeuOVYh|ryP M4CxU|IyOjh7Mk[3
WRO M3jqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTkW484OTByMDFOwG0> NYD6TXhEPSCm MWDEUXNQ M2HwcmlEPTB-MUCwNEDPxE1? NXLOZlVQOjF{OEmyOlc>
TAD2 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNFAxKM7:TR?= MVu1JIQ> NYiwRVB[TE2VTx?= NGDuR5JKSzVyPkGwNFAh|ryP MVeyNVI5QTJ4Nx?=
LN229 MX3BdI9xfG:|aYOgRZN{[Xl? M4LNNlAvPSEQvF2= MUS2NEBp M1XsTGROW09? MUfBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? M2rLR|IzODV5OUG0
T98G M4LXRWFxd3C2b4Ppd{BCe3OjeR?= M2OzW|AvPSEQvF2= M2rJ[VYxKGh? MY\EUXNQ NWDVUHNGSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= MVuyNlA2PzlzNB?=
HC11 NULBcIZ{TnWwY4Tpc44hSXO|YYm= M3zLT|ExKM7:TR?= M2PGR|I1KGh? MUTEUXNQ MU\Jcohq[mm2czFOtk1k[XOnaX6gZY5lKEGGUmCgd5lvfGinc3nz M{XvT|IzPDJ4NkKx
MOLT-4 MWPDfZRwfG:6aXOgRZN{[Xl? Mn;wNVAh|ryP M{n5R|Q5KGh? M4[1eWROW09? NGPhenhKSzVyPUGuO-KBkc7:TR?= MWGyNlYyPDJ2Mx?=
CEM-R NILFSYREgXSxdH;4bYMhSXO|YYm= M3jtUVExKM7:TR?= MmnnOFghcA>? NUPSVZZMTE2VTx?= NETZOGNKSzVyPUOuN-KBkc7:TR?= NVz1PItHOjJ4MUSyOFM>
CEM-S NIDScVdEgXSxdH;4bYMhSXO|YYm= MVmxNEDPxE1? Ml[1OFghcA>? MV7EUXNQ Ml\GTWM2OD13LkJihKnPxE1? NVHLeItqOjJ4MUSyOFM>
MOLT-4 M{TNO2Z2dmO2aX;uJGF{e2G7 Mly1NVAh|ryP NFf4cZQzPCCq M336XWROW09? MXzCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm NGm5U5UzOjZzNEK0Ny=>
MOLT-4 M2\EUmZ2dmO2aX;uJGF{e2G7 NIixc4Q16oDLzszN NV32[Fl2PCCq NH7Xb5VFVVOR M{PTTWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFOzRU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NHTie2gzOjZzNEK0Ny=>
CEM-R M3HuRmZ2dmO2aX;uJGF{e2G7 NVPOdJloPOLCid88US=> MnWwOEBp NXSzSo9jTE2VTx?= NFj4S5VKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? MlrlNlI3OTR{NEO=
CEM-S M1XsS2Z2dmO2aX;uJGF{e2G7 MVO05qCK|ryP NWnrbZhLPCCq MoDqSG1UVw>? NW\PZmFrUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|VCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MYGyNlYyPDJ2Mx?=
HepG2 cell Mkj6T4lv[XOnIFHzd4F6 NVPQVJlyOjBizszN MnPvNlQhcA>? MkHiSG1UVw>? NIHhR3hFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW M3\HeVI{Pzl5M{G5
HepG2 cell M1vYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j3Z|MxKM7:TR?= MoW4NlQhcA>? M3HiNGROW09? M37nUWlvcGmkaYTzJINmdGxiZ4Lve5Rp NUHvfFVMOjN5OUezNVk>
HepG2 cell MVvBdI9xfG:|aYOgRZN{[Xl? MoTTNlAh|ryP Mn;2NlQhcA>? MX7EUXNQ NHzLZVVKdmS3Y3XzJINmdGxiYYDvdJRwe2m| NXHCbG1QOjN5OUezNVk>
GEO NWLhUIk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF72VG82ODBibl2= NYT2eIR[PzJiaB?= NX2ybm5JTE2VTx?= NH61R5ZKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MmWxNlQ2QDF{M{G=
CNE-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfnPZNjOTBizszN NYj4VXlmQTZiaB?= Ml\SSG1UVw>? MlLoTWM2OD1{Lkm2JO69VQ>? NITHRZYzPTN|NkmyOS=>
CNE-2 M2S3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLyNVAh|ryP MXW5OkBp NUPHbIxYTE2VTx?= MnzHTWM2OD12LkWzJO69VQ>? MXmyOVM{Pjl{NR?=
HONE-1 M33P[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTWR|cyOCEQvF2= NET2R446PiCq MnrVSG1UVw>? M1;HUGlEPTB;Mz6zO{DPxE1? M{\NdFI2OzN4OUK1
SUNE-1 NEXXT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrqNVAh|ryP MnzaPVYhcA>? MmXLSG1UVw>? M1TCXGlEPTB;MD61NkDPxE1? MYCyOVM{Pjl{NR?=
CNE-2 MVvGeY5kfGmxbjDBd5NigQ>? M3TXPFExKM7:TR?= MWq0PEBp Mn7vSG1UVw>? NF3MVXJKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz MX6yOVM{Pjl{NR?=
HONE-1 MVTGeY5kfGmxbjDBd5NigQ>? MYqxNEDPxE1? NXL3bWpZPDhiaB?= NV24UWZHTE2VTx?= Mkn5TY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? NFXKNFIzPTN|NkmyOS=>
NEC8 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HYT2lEPTB;MD6wPVY2OSEQvF2= NX;XNHhSW0GQR1XS
P12-ICHIKAWA NGLWeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q1R2lEPTB;MD6xNVYzKM7:TR?= MVrTRW5ITVJ?
MDA-MB-175-VII MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMUO3N|gh|ryP MULTRW5ITVJ?
AsPC-1 NH;pS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDmTWM2OD1yLkKyNVIzKM7:TR?= MYDTRW5ITVJ?
T47D Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz6fG9KSzVyPUCuNlgzPSEQvF2= MXrTRW5ITVJ?
HH Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLUTWM2OD1yLkOwNlg{KM7:TR?= NWHIXYlpW0GQR1XS
MOLT-16 M1rjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwM{CzNkDPxE1? MYrTRW5ITVJ?
ES5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwM{S0OVUh|ryP MoDqV2FPT0WU
RS4-11 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGexb|RKSzVyPUCuN|Q3OSEQvF2= NVnne41GW0GQR1XS
KARPAS-45 M2X5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HKfGlEPTB;MD6zO|MzOSEQvF2= MlfNV2FPT0WU
NCI-H720 M3ryeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjzZYVKSzVyPUCuN|c3PzlizszN MUXTRW5ITVJ?
H9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTsTWM2OD1yLkO4PFg{KM7:TR?= MUHTRW5ITVJ?
EFM-19 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\JOmlEPTB;MD60OFAyKM7:TR?= M3z6UHNCVkeHUh?=
SBC-1 NUXxTWdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r0VGlEPTB;MD60OFA{PSEQvF2= MVrTRW5ITVJ?
A4-Fuk NYHoU4hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC0bYprUUN3ME2wMlQ3QDZ6IN88US=> MnTYV2FPT0WU
NCI-H1563 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT6TWM2OD1yLkS4NVg6KM7:TR?= M{D2bHNCVkeHUh?=
HCC1419 NFjmS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETVZ4xKSzVyPUCuOFg5QTJizszN NUXEcJJsW0GQR1XS
H-EMC-SS NHLVfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknLTWM2OD1yLkS5PVM6KM7:TR?= M2rCVXNCVkeHUh?=
BHT-101 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnHTWM2OD1yLkWyPVYyKM7:TR?= MXLTRW5ITVJ?
IGROV-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\aWVNKSzVyPUCuOVUzPDlizszN MWTTRW5ITVJ?
HGC-27 M1\Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml72TWM2OD1yLkW2O|g{KM7:TR?= NXW1XZNJW0GQR1XS
MDA-MB-361 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XDXWlEPTB;MD61O|c3OSEQvF2= NISwUopUSU6JRWK=
KE-37 NWHudIlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;pXWlEPTB;MD61PFI3KM7:TR?= NX;aPY1wW0GQR1XS
HCC70 M3rwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HEVWlEPTB;MD61PVgzPyEQvF2= MU\TRW5ITVJ?
LNCaP-Clone-FGC NHrZWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jQSmlEPTB;MD62NVA1QCEQvF2= M1;5WnNCVkeHUh?=
HAL-01 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHDUGZKSzVyPUCuOlIyOyEQvF2= NH7Tb2tUSU6JRWK=
HT NWTvXplkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;nUIVlUUN3ME2wMlY{OjN7IN88US=> MlHNV2FPT0WU
MDA-MB-415 M2rIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfuR2VKSzVyPUCuOlM3OjZizszN NEPUZY5USU6JRWK=
NOS-1 M3fLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjBTWM2OD1yLk[zO|I{KM7:TR?= NFq0UXlUSU6JRWK=
DU-145 NIrhfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe2OWpKSzVyPUCuOlQ4PDVizszN MYXTRW5ITVJ?
OCUB-M NXTkXmJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwN{C5OlYh|ryP NWCxOIc2W0GQR1XS
VA-ES-BJ Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLzbZlKSzVyPUCuO|MxOjVizszN NEjZZ3dUSU6JRWK=
J-RT3-T3-5 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iyVWlEPTB;MD63OFQxOyEQvF2= MnT4V2FPT0WU
MOLT-4 M33WfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M131TmlEPTB;MD64NFU5OiEQvF2= MUHTRW5ITVJ?
NB7 M1O2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;IfZpKSzVyPUCuPFI1OTFizszN NIG0e|ZUSU6JRWK=
L-363 MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjYOZd[UUN3ME2wMlg{PDR{IN88US=> MnjUV2FPT0WU
NKM-1 M{X0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwOE[yOVMh|ryP MlnYV2FPT0WU
HOP-92 NVfMOmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHDSGRKSzVyPUCuPFczOjNizszN MmTyV2FPT0WU
OAW-42 NYDYTGs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLOdFR7UUN3ME2wMlg5PzJizszN NEnUTWVUSU6JRWK=
HuO9 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPVYRVUUN3ME2wMlkzPzVzIN88US=> NE[ycYZUSU6JRWK=
MFE-280 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrQeHhKSzVyPUCuPVY1PjVizszN M3XvUnNCVkeHUh?=
EM-2 MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zI[GlEPTB;MD65O|k{QSEQvF2= M{OzNnNCVkeHUh?=
NCI-H520 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\yPXhsUUN3ME2wMlk5PTl{IN88US=> M4WyfHNCVkeHUh?=
LB2241-RCC NVLMXXlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TBU2lEPTB;MD65PVc{PCEQvF2= NXfBTpRXW0GQR1XS
SK-NEP-1 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfOTWM2OD1zLkG0OFg2KM7:TR?= NUHUW5lyW0GQR1XS
LXF-289 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml23TWM2OD1zLkG3NVU3KM7:TR?= NV31XWpQW0GQR1XS
EPLC-272H M{fIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwMUeyOVYh|ryP NFi5TmlUSU6JRWK=
COLO-684 NX76NFNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKdGlEPTB;MT6yN|czPSEQvF2= NH3xVVdUSU6JRWK=
ES1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi3TWM2OD1zLkK0NFY2KM7:TR?= NX\GdYszW0GQR1XS
DOHH-2 NYfjcos5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTZfVVrUUN3ME2xMlI5OjB|IN88US=> Mny4V2FPT0WU
CTB-1 M1vPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV70SVR7UUN3ME2xMlI5QTlizszN MVXTRW5ITVJ?
G-401 M3LmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfRRZhvUUN3ME2xMlI6Pzl3IN88US=> MYDTRW5ITVJ?
LoVo Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn3NotFUUN3ME2xMlMzPTN2IN88US=> Mn7NV2FPT0WU
Ramos-2G6-4C10 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwM{O3NFEh|ryP M4XI[XNCVkeHUh?=
MFM-223 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzHTWM2OD1zLkO0OFYyKM7:TR?= M4TyWHNCVkeHUh?=
PA-1 NFXVdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO1TWM2OD1zLkO1NlY2KM7:TR?= MoPlV2FPT0WU
697 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HZV2lEPTB;MT6zO|YyPiEQvF2= NHzUWopUSU6JRWK=
QIMR-WIL NVrZZ2hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX24Tm1CUUN3ME2xMlQ6OTF4IN88US=> MnLYV2FPT0WU
HOS M{X3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nXN2lEPTB;MT60PVU2QCEQvF2= M1joenNCVkeHUh?=
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HCC1954 NGfWXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17rVGlEPTB;OD60OVExPCEQvF2= MmfuV2FPT0WU
SF126 M3\afWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHsTGdKSzVyPUiuOFU6OzZizszN MX7TRW5ITVJ?
LB996-RCC NWK3TXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRThwNUOyOVch|ryP MnP5V2FPT0WU
SKG-IIIa NH\mV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC3WXY2UUN3ME24MlY{ODZ7IN88US=> MYDTRW5ITVJ?
NCI-SNU-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XCeWlEPTB;OD62OFY1OyEQvF2= MW\TRW5ITVJ?
LB771-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSwZ|hoUUN3ME24MlY1Pjl4IN88US=> MYrTRW5ITVJ?
SCC-4 NIL0NXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi4TWM2OD16Lk[4NlE6KM7:TR?= M1rtfnNCVkeHUh?=
CAMA-1 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L6Z2lEPTB;OD63O|E1PiEQvF2= NFLtdnhUSU6JRWK=
D-502MG NUHzcpZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRThwN{i2Nlkh|ryP MojNV2FPT0WU
ESS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzKTWM2OD16Lki4O|A1KM7:TR?= NGHvZo5USU6JRWK=
HEC-1 NWXaSHJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIThd4xKSzVyPUiuPFk5PjZizszN NH;iXHFUSU6JRWK=
NB10 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[wW|dKSzVyPUmuNFIzOjRizszN NYHVcZdoW0GQR1XS
8505C NHHMW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnSTWM2OD17LkC0NlMzKM7:TR?= MkO0V2FPT0WU
EFO-27 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTlwMU[0NVIh|ryP MlmyV2FPT0WU
HN MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TMbmlEPTB;OT6xOlYzQCEQvF2= MXnTRW5ITVJ?
DSH1 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOybWJKSzVyPUmuNlA5PyEQvF2= MXjTRW5ITVJ?
NBsusSR M4iyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXaNmJwUUN3ME25MlI4PDB{IN88US=> NF34RohUSU6JRWK=
LS-123 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonNTWM2OD17LkOxO|YyKM7:TR?= MljUV2FPT0WU
SHP-77 NFvJcJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnTPXdKSzVyPUmuN|k6OzVizszN NVvzd2hzW0GQR1XS
ACN Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7rUlhiUUN3ME25MlU{Ojd5IN88US=> M3HVNHNCVkeHUh?=
U251 NETacFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTlwNkW1OFQh|ryP MULTRW5ITVJ?
A431 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17hZWlEPTB;OT64NFI{QCEQvF2= MWDTRW5ITVJ?
5637 NFLseW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3LXJFKSzVyPUmuPFQ6QDRizszN NHKydFJUSU6JRWK=
MDA-MB-157 NH3zO5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fENWlEPTB;OT65Nlg4QCEQvF2= NXq0d2hOW0GQR1XS
A101D MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fOVGlEPTB;OT65PVk4PCEQvF2= NWCwSmhFW0GQR1XS
YKG-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFWw[IdKSzVyPUGwMlIxODZizszN MYHTRW5ITVJ?
LAN-6 NWfoTWVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjVW2ZKSzVyPUGwMlIyPjRizszN M132W3NCVkeHUh?=
OVCAR-5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELoco1KSzVyPUGwMlI1OzNizszN MUfTRW5ITVJ?
A549 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTmTWM2OD1zMD6zPVc{KM7:TR?= M3KyZXNCVkeHUh?=
no-11 NVjJV3ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK0TWM2OD1zMD60N|U{KM7:TR?= MnrvV2FPT0WU
SF539 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\GTWM2OD1zMD65NFQyKM7:TR?= MYPTRW5ITVJ?
A388 NHLQUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrYeJFKSzVyPUGxMlM5QTdizszN M1X2UXNCVkeHUh?=
DEL NVrUO257T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjKTWM2OD1zMT60NlQh|ryP MnK3V2FPT0WU
SW954 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPCTWM2OD1zMT60OlY5KM7:TR?= M{XFZnNCVkeHUh?=
TK10 M3K1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13nSWlEPTB;MUGuOVI4OSEQvF2= NXfUTIpEW0GQR1XS
SW756 NFTnTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\mTWM2OD1zMT61Nlk1KM7:TR?= NHTuTohUSU6JRWK=
PC-3 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPXO2xKSzVyPUGxMlU4PjRizszN NYXhbnE2W0GQR1XS
ONS-76 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSyTWM2OD1zMT62N|Yh|ryP M4TxN3NCVkeHUh?=
A427 NUHoTpZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjVTWM2OD1zMT63NFk{KM7:TR?= MlvuV2FPT0WU
MEG-01 M4H0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfOenRnUUN3ME2xNU44PTB7IN88US=> MojmV2FPT0WU
BB30-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjXcmlKSzVyPUGxMlc6QDJizszN MX;TRW5ITVJ?
NCI-H1299 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jnfGlEPTB;MUGuPFA6OyEQvF2= M1TXe3NCVkeHUh?=
GCT NHi5TWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PpdWlEPTB;MUGuPFIzQCEQvF2= MkfxV2FPT0WU
D-247MG NVrYRm9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrUN3ZKSzVyPUGxMlk3PjNizszN MYfTRW5ITVJ?
CFPAC-1 M2TiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHNNFBKSzVyPUGxMlk4QDJizszN NIHBVmxUSU6JRWK=
EKVX MlviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjzcHZKSzVyPUGyMlA{OTNizszN M2XxbnNCVkeHUh?=
CAL-51 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\QZ2lEPTB;MUKuNFcyPiEQvF2= MXPTRW5ITVJ?
BB49-HNC NYLDXosxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDnVYh[UUN3ME2xNk4yOTd5IN88US=> NIfMOHNUSU6JRWK=
RPMI-7951 M3;BSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\1e2lEPTB;MUKuNVg2PCEQvF2= MmDUV2FPT0WU
RH-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nnO2lEPTB;MUKuNlE5PCEQvF2= MXzTRW5ITVJ?
BCPAP MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvMTWM2OD1zMj60O|Q6KM7:TR?= MmHpV2FPT0WU
GCIY M4jpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjpTWM2OD1zMj61NlA6KM7:TR?= M1LtfnNCVkeHUh?=
KNS-81-FD NGn6O21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;sXo9KSzVyPUGyMlU5PjlizszN NIXwV4hUSU6JRWK=
KYSE-140 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF{Lki1PVUh|ryP NGDjUnJUSU6JRWK=
Ca-Ski NGPwTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;s[ZlKSzVyPUGyMlkxPDFizszN NYPYPWlUW0GQR1XS
TGBC1TKB NFuzN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnifIxlUUN3ME2xNk46OTF3IN88US=> MmK5V2FPT0WU
HCC1187 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjTR3ZKSzVyPUGzMlE6OTJizszN NVjKUZczW0GQR1XS
SJSA-1 NW\6Zmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzETWM2OD1zMz6yN|I4KM7:TR?= MV7TRW5ITVJ?
CTV-1 M3G5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF|LkO0OUDPxE1? NU\SS4M1W0GQR1XS
WM-115 M{noOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vyS2lEPTB;MUOuOlQ5OyEQvF2= M1KzPXNCVkeHUh?=
CHP-212 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPNb|VWUUN3ME2xN{46PzN7IN88US=> Ml:3V2FPT0WU
SCC-15 NIKyRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rCN2lEPTB;MUOuPVc4PSEQvF2= M{XkOnNCVkeHUh?=
BPH-1 M{DwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PSVGlEPTB;MUSuNVY3PCEQvF2= Mk\MV2FPT0WU
SW780 NWrtN|JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\1[ItKSzVyPUG0MlUxOjVizszN NXvlS2RUW0GQR1XS
NCI-H2291 NWfwN4h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjKV|I6UUN3ME2xOE42QDd6IN88US=> M2X3WnNCVkeHUh?=
JEG-3 M{jmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzOUXJKSzVyPUG0MlY{OjZizszN M3zkWXNCVkeHUh?=
CAL-120 NEPrXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrtTWM2OD1zND63NFI4KM7:TR?= NGXMc5BUSU6JRWK=
NCI-H23 NF62UXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\0TWM2OD1zND63PVk4KM7:TR?= NWX0OHUxW0GQR1XS
MS-1 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn3elNKSzVyPUG0Mlk3OTFizszN NWTsSGk{W0GQR1XS
PC-14 NFvyXJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT6WXVKSzVyPUG0Mlk3PTRizszN NHvLNZhUSU6JRWK=
D-283MED NVXF[|loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDlXHRqUUN3ME2xOU4xOTFzIN88US=> M2TFV3NCVkeHUh?=
OE19 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi3b3d{UUN3ME2xOU4yPTRzIN88US=> M1vRTXNCVkeHUh?=
CAS-1 M2TvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj4TWM2OD1zNT60NVg1KM7:TR?= NVjLdFN7W0GQR1XS
NCI-H727 NFLWWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jPRWlEPTB;MUWuOFIzOSEQvF2= NVi5ZVA4W0GQR1XS
SiHa NGCyVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme4TWM2OD1zNT63OVk1KM7:TR?= M4K4UHNCVkeHUh?=
BFTC-905 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DC[mlEPTB;MUWuO|Y6PCEQvF2= NXn2SXZqW0GQR1XS
MDA-MB-453 M{fncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF4LkG2OFIh|ryP MWHTRW5ITVJ?
HuP-T3 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF4Lk[zO|Mh|ryP MXHTRW5ITVJ?
SK-LU-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTNWoRmUUN3ME2xOk43QTV4IN88US=> MkC5V2FPT0WU
Detroit562 M3OyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjrTWM2OD1zNj63N|E5KM7:TR?= MXzTRW5ITVJ?
HCC1569 MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPnTWM2OD1zNj64N|M4KM7:TR?= M4DlfXNCVkeHUh?=
SK-MES-1 NGDPSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP1NGhKSzVyPUG2Mlg1OTlizszN NFnNS4hUSU6JRWK=
BB65-RCC M2\Q[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF5LkC0O|kh|ryP NUDKUos{W0GQR1XS
LOXIMVI Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PqOmlEPTB;MUeuNFcxPyEQvF2= MnPiV2FPT0WU
SW1783 M4rL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK3ToZlUUN3ME2xO{4yOjhizszN NXXWW2pLW0GQR1XS
NH-12 NELqOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33Rd2lEPTB;MUeuN|MxOyEQvF2= MVjTRW5ITVJ?
UACC-257 NFuzWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF5LkW1NVIh|ryP MYLTRW5ITVJ?
KOSC-2 NWmxZZFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPqTWM2OD1zNz62O|U4KM7:TR?= MUXTRW5ITVJ?
KG-1 NVTUfld6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLoTWM2OD1zNz62PVM4KM7:TR?= NX:xe|k2W0GQR1XS
M059J MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF5LkewN{DPxE1? MlSxV2FPT0WU
MHH-NB-11 NHPVfm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF5Lkm2O|Mh|ryP MmXVV2FPT0WU
EW-1 NX:3d3kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOwTWM2OD1zOD6xN|gzKM7:TR?= NX3kNGt2W0GQR1XS
CAL-85-1 NFXHPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXizZXFEUUN3ME2xPE4zOzV5IN88US=> MojiV2FPT0WU
639-V M3vnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF6LkOzOVQh|ryP NIrhZnVUSU6JRWK=
C32 NV22Xo5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zHUmlEPTB;MUiuOFczPyEQvF2= MoTCV2FPT0WU
KM-H2 M4H3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX6TWM2OD1zOD61NlMzKM7:TR?= MkDKV2FPT0WU
A253 NYK0OVV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jtOWlEPTB;MUiuO|I5PiEQvF2= MUDTRW5ITVJ?
NCI-N87 NWjOeXlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULFR|VbUUN3ME2xPE46ODB6IN88US=> M{jafXNCVkeHUh?=
8-MG-BA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF7LkC2OFYh|ryP MXrTRW5ITVJ?
GI-ME-N M4XWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ju[mlEPTB;MUmuNVU1PiEQvF2= NXvQdYpHW0GQR1XS
8305C M{PHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjUfVh5UUN3ME2xPU4zOjh4IN88US=> MVHTRW5ITVJ?
TE-8 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrK[WFzUUN3ME2xPU4{ODJ2IN88US=> NF\ybXdUSU6JRWK=
KYSE-270 NVHoN491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HNXmlEPTB;MkCuNFIyPyEQvF2= NI\MR4lUSU6JRWK=
HL-60 Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u0e2lEPTB;MkCuNFk1OSEQvF2= M3fKT3NCVkeHUh?=
Mo-T NVm2e|lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfQNIFiUUN3ME2yNE4yPjZ3IN88US=> NIDWbYNUSU6JRWK=
NCI-H1355 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXaTWM2OD1{MD6zN|c1KM7:TR?= NH;CN|ZUSU6JRWK=
HT-1080 NEDZSJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXsTWM2OD1{MD61OFk4KM7:TR?= MXXTRW5ITVJ?
MIA-PaCa-2 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjYOIFwUUN3ME2yNE43QDh|IN88US=> M2nVOnNCVkeHUh?=
NCI-H441 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnJSHlrUUN3ME2yNE44Ozd7IN88US=> MonHV2FPT0WU
LCLC-97TM1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzVTWM2OD1{MD64NVM1KM7:TR?= NGDCflhUSU6JRWK=
HT-3 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHkT2VKSzVyPUKxMlU3OzFizszN NVLXOJF7W0GQR1XS
22RV1 NX\K[Fd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXTTWM2OD1{MT61Olg2KM7:TR?= M2nDNnNCVkeHUh?=
LK-2 NHfvSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf5TplKSzVyPUKxMlU6PTNizszN MV;TRW5ITVJ?
CW-2 M4\GV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJzLk[wOlkh|ryP NGj2bopUSU6JRWK=
KYSE-510 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj3fmhKSzVyPUKxMlYxQTVizszN MkHKV2FPT0WU
CGTH-W-1 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S4OWlEPTB;MkGuO|E3PiEQvF2= MkjqV2FPT0WU
NCI-H661 M2LGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HKU2lEPTB;MkKuNFM1KM7:TR?= MUDTRW5ITVJ?
KU-19-19 NFnLXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPHTWM2OD1{Mj6xOlk4KM7:TR?= M2jl[nNCVkeHUh?=
NCI-H2122 NVz4SY5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn62TWM2OD1{Mj6yOFMzKM7:TR?= MXnTRW5ITVJ?
NCI-H526 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3WSY1KSzVyPUKyMlM5QTVizszN NUL5bHJrW0GQR1XS
NCI-H1650 NU\teYZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m4OWlEPTB;MkKuO|Y1KM7:TR?= M2HUOHNCVkeHUh?=
AM-38 MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfOTWM2OD1{Mj64Olg6KM7:TR?= NV7LV4dHW0GQR1XS
NCI-H2405 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD1{Mz6yOVM{KM7:TR?= M2\NXnNCVkeHUh?=
M14 M1vEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPlTWM2OD1{Mz60NFg5KM7:TR?= Ml:1V2FPT0WU
ES4 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q0[GlEPTB;MkOuOFI{OiEQvF2= MWLTRW5ITVJ?
DJM-1 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHlTWM2OD1{Mz61NlM1KM7:TR?= NFjtVGZUSU6JRWK=
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NCI-H1581 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvCU5BCUUN3ME24OU41PjRzIN88US=> NYe4WmNxW0GQR1XS
KARPAS-299 NV\MNY4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzWTWM2OD16Nj6xPVc4KM7:TR?= MYDTRW5ITVJ?
IST-MEL1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnCR4NKSzVyPUi2Mlg5PzJizszN MlPjV2FPT0WU
KP-N-YS NVXybFFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HzNWlEPTB;OEmuPVAzQCEQvF2= MnzLV2FPT0WU
KYSE-410 NWLXc3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[2OHdiUUN3ME25NU41ODR{IN88US=> MUPTRW5ITVJ?
TE-10 NVPqXYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLCR|ZCUUN3ME25NU42PjFzIN88US=> MlexV2FPT0WU
SK-MEL-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\5VWFLUUN3ME25Nk46OTB4IN88US=> NVjZN4FJW0GQR1XS
COLO-792 NIqzclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTl3LkK1OlQh|ryP MnzzV2FPT0WU
SCH NH\XbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTl4LkO4O|ch|ryP MX\TRW5ITVJ?
NCI-H1792 NY[0cnFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTl4Lki5PVIh|ryP MmL3V2FPT0WU
NCI-H2029 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;sWWNxUUN3ME25Ok46PTZ4IN88US=> NIO0[2VUSU6JRWK=
SW684 NHmzNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[ybFdKSzVyPUm4MlY3PTRizszN MW\TRW5ITVJ?
NCI-H209 M2HB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K3W2lEPTB;MUCwMlEzOSEQvF2= NIK3XVBUSU6JRWK=
HLE MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1mxR2lEPTB;MUC1MlI5OiEQvF2= NFHPfoNUSU6JRWK=
GOTO NXvrdGE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfBTWM2OD1zMEeuO|c4KM7:TR?= NWfKZXVJW0GQR1XS
NCI-H1793 MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFyOT6yPEDPxE1? MlvIV2FPT0WU
D-392MG M3rVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFzNz6zPVgh|ryP Mmj2V2FPT0WU
SW1990 NUH6S4c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF{MD65OVEh|ryP NYjBR20zW0GQR1XS
ML-2 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF{MT62O|Yh|ryP MXXTRW5ITVJ?
NCI-H2452 NWq2b|A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1roWWlEPTB;MUKyMlIyKM7:TR?= M2jlW3NCVkeHUh?=
SK-MEL-30 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny1TWM2OD1zMkOuNlQ1KM7:TR?= NGnNdIRUSU6JRWK=
SN12C MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme1TWM2OD1zMkSuNVc3KM7:TR?= Mn7mV2FPT0WU
NCI-H1770 NIHV[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe1[GtjUUN3ME2xNlUvPTF2IN88US=> MUPTRW5ITVJ?
SF268 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fSfmlEPTB;MUK2MlE2QCEQvF2= MmL3V2FPT0WU
BALL-1 NF63NlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrzR2RKSzVyPUGyOk4zOyEQvF2= MoHjV2FPT0WU
COLO-679 M3[wO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF{Nj63OVMh|ryP M1fOPXNCVkeHUh?=
A2780 NXywVJNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jZNWlEPTB;MUK4Mlk5QCEQvF2= MVTTRW5ITVJ?
NCI-H1651 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC1bHAxUUN3ME2xN|EvOjR|IN88US=> NXS2bXB7W0GQR1XS
NCI-H2087 NEXpbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TjZmlEPTB;MUOxMlQ5OyEQvF2= NELEU4NUSU6JRWK=
U-87-MG NVHXSYRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\wZ2lEPTB;MUOzMlYxPCEQvF2= Mk[yV2FPT0WU
LB2518-MEL M1yyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnWTWM2OD1zM{WuPVk{KM7:TR?= MWXTRW5ITVJ?
HCT-116 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTJTWM2OD1zM{euNlE4KM7:TR?= NIr2ZnRUSU6JRWK=
Ca9-22 NEHPV2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHWZYlCUUN3ME2xN|kvQDN|IN88US=> NVzIO|VpW0GQR1XS
COR-L88 M4nlNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF2Mj6xOEDPxE1? NE\4RVhUSU6JRWK=
CP50-MEL-B NXPzeWI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\oTWM2OD1zNESuOVAyKM7:TR?= NV7udFByW0GQR1XS
OVCAR-8 NUi1VVRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF2NT62N|Yh|ryP M2nuenNCVkeHUh?=
SK-MEL-3 NVKzfmU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF2Nz64O|gh|ryP NWLxZ25YW0GQR1XS
GT3TKB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF2OT65Nlgh|ryP MmPLV2FPT0WU
KYSE-450 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvoS3RKSzVyPUG1NU42OzlizszN NVzLT41ZW0GQR1XS
CAPAN-1 NHrYW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPudoxSUUN3ME2xOVMvODZ2IN88US=> MUHTRW5ITVJ?
BEN NX2zVlZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPvOYlKSzVyPUG1N{46OjhizszN M4Tw[XNCVkeHUh?=
NCI-H1304 NVfF[WlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCwTWM2OD1zNUSuOlk1KM7:TR?= MoXpV2FPT0WU
KU812 NYHzOWdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr5NZFYUUN3ME2xOVgvPjd2IN88US=> NFTndI9USU6JRWK=
Capan-2 M1PmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF4MD61OVMh|ryP NGq2T2VUSU6JRWK=
A673 M{eydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX1WHpKSzVyPUG2NU44ODVizszN NHzFcoJUSU6JRWK=
SAS M1nOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDod|R3UUN3ME2xOlIvPjd6IN88US=> NHL4[2FUSU6JRWK=
NY M2m1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq5WVZKSzVyPUG2OU4{OTRizszN M1\JenNCVkeHUh?=
HCE-4 NFfXXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1eY9kUUN3ME2xOlYvQDR3IN88US=> M2\YdXNCVkeHUh?=
MDA-MB-231 NIDmUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\jUpBoUUN3ME2xO|cvPTB|IN88US=> NV7qc3dHW0GQR1XS
no-10 M3zzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf2U|FKSzVyPUG3PE4yOzRizszN NF7GZ|ZUSU6JRWK=
MZ7-mel MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYTWM2OD1zN{iuOFY4KM7:TR?= MUPTRW5ITVJ?
NCI-H82 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF6MD6xOlUh|ryP MkT4V2FPT0WU
CAL-72 MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml36TWM2OD1zOEWuNFU1KM7:TR?= M{T3d3NCVkeHUh?=
NCI-SNU-5 M3[yZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL2NmV5UUN3ME2xPFYvQDRizszN MXvTRW5ITVJ?
OVCAR-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\TNndKSzVyPUG4PE4{OzNizszN M17JTnNCVkeHUh?=
SCC-9 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTUdGM4UUN3ME2xPVEh|ryP M4rZbHNCVkeHUh?=
KYSE-150 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLyXllRUUN3ME2xPVEvQDh6IN88US=> MnrxV2FPT0WU
HT-29 M4Tnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj6XI5NUUN3ME2yNFEvOjF{IN88US=> M1vXNHNCVkeHUh?=
COLO-678 NX[0WoJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jvVGlEPTB;MkCxMlQ2KM7:TR?= NYjtbVF[W0GQR1XS
NCI-H650 M1\hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJyMj6xNFMh|ryP MlzlV2FPT0WU
HuCCT1 NF3DcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJyND6yNFgh|ryP MkHGV2FPT0WU
SW1116 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[0T5RKSzVyPUKwO{4xPzdizszN MXnTRW5ITVJ?
DBTRG-05MG MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnoTWM2OD1{MEeuPVA6KM7:TR?= M3P0VXNCVkeHUh?=
SW982 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJyNz65OFgh|ryP NIjyNHdUSU6JRWK=
RCM-1 NED5dG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;Ed2tKSzVyPUKxOE44PjJizszN NX6xeWtRW0GQR1XS
COLO-320-HSR M1rDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37BdGlEPTB;MkG2MlEzPSEQvF2= NGLU[GNUSU6JRWK=
KNS-42 NX7ZVlgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYK0foZIUUN3ME2yNVYvPTd2IN88US=> MXPTRW5ITVJ?
C2BBe1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfRd4FKSzVyPUKzNU46ODVizszN MkP5V2FPT0WU
CCRF-CEM MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LoZ2lEPTB;MkSzMlc6PSEQvF2= MVXTRW5ITVJ?
SH-4 NFWxboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S5SGlEPTB;MkS2MlA6KM7:TR?= MWLTRW5ITVJ?
LS-1034 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WzVGlEPTB;MkS2MlI3PiEQvF2= NE\6RXlUSU6JRWK=
NCI-H2347 NYTmRYpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ2Nz63NVMh|ryP MnXPV2FPT0WU
RPMI-8866 M3vJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ2OT6yO{DPxE1? MlnUV2FPT0WU
GAK MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjCTWM2OD1{NUOuNFAzKM7:TR?= MnfpV2FPT0WU
NB6 NGjTR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\rSGlEPTB;MkewMlEh|ryP MXzTRW5ITVJ?
COLO-680N NWi4WmtzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vC[mlEPTB;MkeyMlUzPyEQvF2= NULPZXd6W0GQR1XS
RERF-LC-MS M1LNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fYWWlEPTB;Mke2MlAxPyEQvF2= NIHUV2RUSU6JRWK=
TGBC11TKB MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnRTWM2OD1{N{iuNVc5KM7:TR?= NEXyS21USU6JRWK=
C8166 M{\Cc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ5OD61NFYh|ryP M{PO[XNCVkeHUh?=
HDLM-2 M3fETmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDiUnRKSzVyPUK5OE41ODlizszN NEnGPHRUSU6JRWK=
IGR-1 NEi4eoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\yfIRPUUN3ME2yPVUvPjV7IN88US=> Mn\QV2FPT0WU
FADU NH75W|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPqXGpKSzVyPUK5O{42OSEQvF2= MkDHV2FPT0WU
L-428 NWe0c|RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHUWJc{UUN3ME2yPVcvPjF4IN88US=> NIfnUI1USU6JRWK=
LU-65 M3rXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCze4U1UUN3ME2zNFQvOzJizszN NF32VndUSU6JRWK=
HEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonvTWM2OD1|MEmuPVg{KM7:TR?= M1\aTXNCVkeHUh?=
NCI-H810 NX:zNJI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNzMD61O{DPxE1? NV7zZpJCW0GQR1XS
C3A NUnCdWtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTj[HlWUUN3ME2zNVEvQDB{IN88US=> NFTBWmVUSU6JRWK=
NCI-H630 M{[yeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN|Mj6yPVQh|ryP M3Hob3NCVkeHUh?=
KP-N-YN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[yNXZKSzVyPUO0NU4yOjNizszN Ml;iV2FPT0WU
MOLT-13 NFjmZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y1bmlEPTB;M{SyMlMzPiEQvF2= MYXTRW5ITVJ?
NCI-H1993 NIrsZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPsdVBKSzVyPUO0Nk4{PjVizszN NYjET4V5W0GQR1XS
BE-13 M1jiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TZTGlEPTB;M{S0MlE3PyEQvF2= Mnr3V2FPT0WU
IST-SL1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrEflJKSzVyPUO0O{41ODFizszN NIize2hUSU6JRWK=
TE-9 NXf3endiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nPcmlEPTB;M{[zMlU5QSEQvF2= NH3zclBUSU6JRWK=
LU-135 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjVS2JKSzVyPUO2O{4xOzVizszN MkPJV2FPT0WU
T84 NUfycHl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\mNmlEPTB;M{e0MlcyOiEQvF2= Mlf1V2FPT0WU
K-562 M4T3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWraUVdnUUN3ME2zPFMvOzZizszN NETi[3VUSU6JRWK=
SBC-5 NInDXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3XUo5KSzVyPUO4Ok46QDVizszN MoT4V2FPT0WU
NB17 M3K4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor2TWM2OD1|OUKuOVk3KM7:TR?= MnHsV2FPT0WU
NCI-H2052 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Tn[WlEPTB;M{m4MlQ4OiEQvF2= M3LVb3NCVkeHUh?=
HCC38 M1TTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTRyMT61PVMh|ryP NYr0dFNYW0GQR1XS
NCI-H69 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvTTWM2OD12NEGuNFg{KM7:TR?= NVHnVnRUW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

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Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

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  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Formulation: Formulated in 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID