MK-2206 2HCl

For research use only.

Catalog No.S1078

1011 publications

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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Selleck's MK-2206 2HCl has been cited by 1011 publications

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NH7udlREgXSxdH;4bYMhSXO|YYm= NIW2OGM{KM7:TR?= NVjWdINwPzJiaB?= MYfEUXNQ M1rW[GlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w MlXENlA2PzFyNkm=
A431 M{mze2tqdmG|ZTDBd5NigQ>? MlHqOUDPxE1? NE\xSlY2KGh? NXTKeo1MTE2VTx?= NXfaO2U3W3WycILld5NmeyC2aHWgd4lodmGuaX7nJI9nKEGtdDDhcoQhTXKt NGW3[XIzODV5MUC2PS=>
HepG2 NIr0N2tEgXSxdH;4bYMhSXO|YYm= NGTrc48yOCEQvF2= MmfpNlQhcA>? M2X6d2ROW09? NFThNY5U\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> M2rDPVIyOjB3OUK1
Sk-Hep1 NHG5RmxEgXSxdH;4bYMhSXO|YYm= M4DEPFExKM7:TR?= NGjKV2szPCCq MVrEUXNQ MVfT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= MkDnNlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) MlfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGzJO69VQ>? MUC1JIQ> NEnGe3hFVVOR MXnJR|UxRTBwMUSg{txO MmnpNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) NFX3UFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHxTnE{KM7:TR?= NW\lU|dNPSCm MoXCSG1UVw>? NELNdGdKSzVyPUCuOVIh|ryP MlzSNlEzQDl{Nke=
FTC133 cells harbored PTEN (allele deletion and R130+) MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW3e3dPOyEQvF2= M3\DTVUh\A>? NHv2NnZFVVOR NFv5PWFKSzVyPUCuNVgh|ryP Mle2NlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUWzJO69VQ>? NXnHfmU{PSCm M3n1cmROW09? M1L3dWlEPTB;MD6yO{DPxE1? NVLVUZp2OjF{OEmyOlc>
Hth7 cells harbored NRAS (Q61R+/−) M1Hwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\BN{DPxE1? MX61JIQ> Mkf4SG1UVw>? MmeyTWM2OD12LkWg{txO NI\zSHczOTJ6OUK2Oy=>
TPC1 cells harbored RET/PTC1 rearrangement MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi3eXBFOyEQvF2= NWHpNZB{PSCm MUDEUXNQ MlXaTWM2OD1yLkW5JO69VQ>? NEG1TlMzOTJ6OUK2Oy=>
Hth74 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3yN{DPxE1? MoDQOUBl NH3we25FVVOR NYLWT|RHUUN3ME2yMlE6KM7:TR?= M2nHVFIyOjh7Mk[3
KAT18 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWmzJO69VQ>? M3zuOVUh\A>? NW\odZlQTE2VTx?= NFPmN2hKSzVyPUSuOlIh|ryP NIrHZ4ozOTJ6OUK2Oy=>
SW1736 NWDSXJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;CdVR{OTByIN88US=> M2PBSlUh\A>? NHHZN4xFVVOR M3K0emlEPTB;NEeuOVYh|ryP M2HTPVIyOjh7Mk[3
WRO NFvxSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNFAxKM7:TR?= NXS5foFxPSCm NWDGTXJsTE2VTx?= MlznTWM2OD5zMECwJO69VQ>? MmnGNlEzQDl{Nke=
TAD2 NXvIPZhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNFAxKM7:TR?= M3q4XVUh\A>? MUfEUXNQ NVW2SZl4UUN3ME6xNFAxKM7:TR?= NGXQZlMzOTJ6OUK2Oy=>
LN229 Mly5RZBweHSxc3nzJGF{e2G7 NYfZeos3OC53IN88US=> NIn4XIg3OCCq NYj2dGVoTE2VTx?= NFvBSWZCfWevZX70d{BieG:ydH;n[Y5q[yCnZn\lZ5R{KG:oIHfl[ol1cW6rYh?= NFH1R3MzOjB3N{mxOC=>
T98G NEH2NnpCeG:ydH;zbZMhSXO|YYm= MlL4NE42KM7:TR?= NV;2dnlqPjBiaB?= M162OWROW09? NILEN|BCfWevZX70d{BieG:ydH;n[Y5q[yCnZn\lZ5R{KG:oIHfl[ol1cW6rYh?= NHrEem0zOjB3N{mxOC=>
HC11 MVzGeY5kfGmxbjDBd5NigQ>? MVSxNEDPxE1? MUGyOEBp MmH1SG1UVw>? NGTad2VKdmirYnn0d{DPui2lYYPlbY4h[W6mIFHEVnAhe3mwdHjld4l{ NYeycYdGOjJ2Mk[2NlE>
MOLT-4 NXj0PYU5S3m2b4TvfIlkKEG|c3H5 NVTidmlHOTBizszN M1XudlQ5KGh? NEP2VFVFVVOR NEntbZJKSzVyPUGuO-KBkc7:TR?= M4jIXlIzPjF2MkSz
CEM-R MkfFR5l1d3SxeHnjJGF{e2G7 MmTWNVAh|ryP NXzEeWxYPDhiaB?= MmDZSG1UVw>? M1LZWWlEPTB;Mz6z5qCK|ryP NF30WHgzOjZzNEK0Ny=>
CEM-S MoPrR5l1d3SxeHnjJGF{e2G7 NIHMfWgyOCEQvF2= M1PWN|Q5KGh? M2nUXmROW09? M{jWVmlEPTB;NT6x5qCK|ryP Ml3GNlI3OTR{NEO=
MOLT-4 NUfoOYJPTnWwY4Tpc44hSXO|YYm= Ml[1NVAh|ryP MnS2NlQhcA>? NYr4R|hvTE2VTx?= MmHmRoxw[2u|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? NYLJU|BVOjJ4MUSyOFM>
MOLT-4 NF;HR4xHfW6ldHnvckBCe3OjeR?= NFHLbFE16oDLzszN NWDzXJFTPCCq M3fhVWROW09? MUXJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> NFS5d4YzOjZzNEK0Ny=>
CEM-R NHrzZ2dHfW6ldHnvckBCe3OjeR?= MmHhOQKBkc7:TR?= NFK0bHg1KGh? MYLEUXNQ NYTUS|VEUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|RCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ M3zYfVIzPjF2MkSz
CEM-S M{ntXmZ2dmO2aX;uJGF{e2G7 M4m3UVTjiIoQvF2= NVfSXWwxPCCq MUTEUXNQ Ml\yTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{XBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz M4nDNVIzPjF2MkSz
HepG2 cell NUjMWopTU2mwYYPlJGF{e2G7 NV\tN3VuOjBizszN M1TselI1KGh? M4rsPGROW09? NED5WGpFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW NISwS2MzOzd7N{OxPS=>
HepG2 cell M1rnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3Ibm4{OCEQvF2= NHr5eIczPCCq M4DqNGROW09? NU\XZ4ZjUW6qaXLpeJMh[2WubDDndo94fGh? NYDvUVFUOjN5OUezNVk>
HepG2 cell MlnMRZBweHSxc3nzJGF{e2G7 M2XmcVIxKM7:TR?= MVmyOEBp MmXnSG1UVw>? MkLpTY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MlPTNlM4QTd|MUm=
GEO MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nTXlUxOCCwTR?= NH;wXJE4OiCq NVnkZlFITE2VTx?= Mnj4TY5pcWKrdIOgZ4VtdCCpcn;3eIg> NEnRfIUzPDV6MUKzNS=>
CNE-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqx[5AyOCEQvF2= MWK5OkBp Mn7USG1UVw>? NIfMUnVKSzVyPUKuPVYh|ryP M4fZOlI2OzN4OUK1
CNE-2 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvNVAh|ryP MXO5OkBp MUDEUXNQ NUnte2lUUUN3ME20MlU{KM7:TR?= NXfpUlBlOjV|M{[5NlU>
HONE-1 NH30XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWCxNEDPxE1? M1XTXFk3KGh? NIT4VoNFVVOR Ml7kTWM2OD1|LkO3JO69VQ>? M{XwcVI2OzN4OUK1
SUNE-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnYNVAh|ryP Mn3VPVYhcA>? MkD1SG1UVw>? MUPJR|UxRTBwNUKg{txO MUWyOVM{Pjl{NR?=
CNE-2 MnHSSpVv[3Srb36gRZN{[Xl? Ml35NVAh|ryP NHK4VoE1QCCq NWGweVlNTE2VTx?= NXPxeZpFUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= NX3uOlA{OjV|M{[5NlU>
HONE-1 NFzWNI5HfW6ldHnvckBCe3OjeR?= M16zTFExKM7:TR?= NUHpcGgyPDhiaB?= NWHHRYVSTE2VTx?= NVLYVI9sUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= MlzrNlU{OzZ7MkW=
NEC8 MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkntTWM2OD1yLkC5OlUyKM7:TR?= MmDRV2FPT0WU
P12-ICHIKAWA MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fRUGlEPTB;MD6xNVYzKM7:TR?= NITSW45USU6JRWK=
MDA-MB-175-VII MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkmwTWM2OD1yLkGzO|M5KM7:TR?= MULTRW5ITVJ?
AsPC-1 NGHBdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMkKxNlIh|ryP MlPJV2FPT0WU
T47D NYjNV3JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nNVWlEPTB;MD6yPFI2KM7:TR?= MWHTRW5ITVJ?
HH MmHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\ZTWM2OD1yLkOwNlg{KM7:TR?= NX3Jb3RXW0GQR1XS
MOLT-16 NFfk[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TW[2lEPTB;MD6zNFMzKM7:TR?= MkPKV2FPT0WU
ES5 NXjHTmlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvxNVdKSzVyPUCuN|Q1PTVizszN MmLDV2FPT0WU
RS4-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne0TWM2OD1yLkO0OlEh|ryP NHOwZmhUSU6JRWK=
KARPAS-45 NXTY[XdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwM{ezNlEh|ryP NXu4TIJHW0GQR1XS
NCI-H720 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLZSnJKSzVyPUCuN|c3PzlizszN MlHWV2FPT0WU
H9 NVzKWWNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKzRnVKSzVyPUCuN|g5QDNizszN NEHIOWJUSU6JRWK=
EFM-19 M4rM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTJTWM2OD1yLkS0NFEh|ryP MnzYV2FPT0WU
SBC-1 M1LBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofZTWM2OD1yLkS0NFM2KM7:TR?= MWfTRW5ITVJ?
A4-Fuk M3[z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwNE[4Olgh|ryP NGrsTIhUSU6JRWK=
NCI-H1563 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP3NpZPUUN3ME2wMlQ5OTh7IN88US=> MnHOV2FPT0WU
HCC1419 NWfZd3FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\4TWM2OD1yLkS4PFkzKM7:TR?= MVHTRW5ITVJ?
H-EMC-SS NEXadpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDqdFZTUUN3ME2wMlQ6QTN7IN88US=> MmfiV2FPT0WU
BHT-101 NVzLSGt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{izbGlEPTB;MD61Nlk3OSEQvF2= NI[1Z2lUSU6JRWK=
IGROV-1 NYDtbWFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnwcmZKSzVyPUCuOVUzPDlizszN M{XvT3NCVkeHUh?=
HGC-27 NHq0TVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M335VGlEPTB;MD61Olc5OyEQvF2= NF7LelhUSU6JRWK=
MDA-MB-361 M{jSNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2L2UmlEPTB;MD61O|c3OSEQvF2= NEnzTmxUSU6JRWK=
KE-37 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;Ed2lEPTB;MD61PFI3KM7:TR?= NXrOcm57W0GQR1XS
HCC70 NEDZOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXDVI5KSzVyPUCuOVk5OjdizszN NWmxVG9LW0GQR1XS
LNCaP-Clone-FGC NEnZRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jOPWlEPTB;MD62NVA1QCEQvF2= MmjBV2FPT0WU
HAL-01 MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnMS4dKSzVyPUCuOlIyOyEQvF2= NH;6fXFUSU6JRWK=
HT NEDOO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\vOVVNUUN3ME2wMlY{OjN7IN88US=> NHnKOlVUSU6JRWK=
MDA-MB-415 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG2PFFKSzVyPUCuOlM3OjZizszN NUnFUmxmW0GQR1XS
NOS-1 NYXvZoFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNkO3NlMh|ryP MkGxV2FPT0WU
DU-145 NUS5Wml5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELHWGlKSzVyPUCuOlQ4PDVizszN MmnaV2FPT0WU
OCUB-M NXuzNIZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnvUlJKSzVyPUCuO|A6PjZizszN M3u3XHNCVkeHUh?=
VA-ES-BJ M4jwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmntTWM2OD1yLkezNFI2KM7:TR?= MnLKV2FPT0WU
J-RT3-T3-5 M1fSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS0fVZKSzVyPUCuO|Q1ODNizszN M1jEWnNCVkeHUh?=
MOLT-4 NX:5dlNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\OfZV{UUN3ME2wMlgxPTh{IN88US=> M3PKTXNCVkeHUh?=
NB7 NHzIbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nEXmlEPTB;MD64NlQyOSEQvF2= M3v1cHNCVkeHUh?=
L-363 M1Prd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnTN4NKSzVyPUCuPFM1PDJizszN NUC4WJhFW0GQR1XS
NKM-1 M1ntXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLlXHYzUUN3ME2wMlg3OjV|IN88US=> MoTIV2FPT0WU
HOP-92 MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHlSYVKSzVyPUCuPFczOjNizszN M1f0NnNCVkeHUh?=
OAW-42 NVXjZmFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjRTWM2OD1yLki4O|Ih|ryP NGrOc29USU6JRWK=
HuO9 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULUWmc5UUN3ME2wMlkzPzVzIN88US=> MXzTRW5ITVJ?
MFE-280 NIHkOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nIWGlEPTB;MD65OlQ3PSEQvF2= M{fUWHNCVkeHUh?=
EM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjQdohKSzVyPUCuPVc6OzlizszN NYS0XItUW0GQR1XS
NCI-H520 M3HDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\4UJREUUN3ME2wMlk5PTl{IN88US=> NUm2e41LW0GQR1XS
LB2241-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M124bGlEPTB;MD65PVc{PCEQvF2= M1vWSnNCVkeHUh?=
SK-NEP-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofoTWM2OD1zLkG0OFg2KM7:TR?= NIjWRldUSU6JRWK=
LXF-289 NIG1OmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;DOmhKSzVyPUGuNVcyPTZizszN NXmxeW5VW0GQR1XS
EPLC-272H NXu2[|NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDD[HRuUUN3ME2xMlE4OjV4IN88US=> NUOydpJSW0GQR1XS
COLO-684 NF7ncmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwMkO3NlUh|ryP M{D5eXNCVkeHUh?=
ES1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjPS4NCUUN3ME2xMlI1ODZ3IN88US=> NEDz[FVUSU6JRWK=
DOHH-2 NXLuUId6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO3TWM2OD1zLkK4NlA{KM7:TR?= NFG5TmNUSU6JRWK=
CTB-1 NG\weHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj2NldXUUN3ME2xMlI5QTlizszN NGTZdFNUSU6JRWK=
G-401 M17NOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7YcZRKSzVyPUGuNlk4QTVizszN MoH6V2FPT0WU
LoVo NWDCN5lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwM{K1N|Qh|ryP NXj5S5J[W0GQR1XS
Ramos-2G6-4C10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDKR|NbUUN3ME2xMlM{PzBzIN88US=> NVO4VnJVW0GQR1XS
MFM-223 NWTC[YNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwfmlEPTB;MT6zOFQ3OSEQvF2= MUXTRW5ITVJ?
PA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLITWM2OD1zLkO1NlY2KM7:TR?= MXfTRW5ITVJ?
697 NGrsUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTFwM{e2NVYh|ryP MXPTRW5ITVJ?
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HCC1954 NHuxOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XZemlEPTB;OD60OVExPCEQvF2= MmHIV2FPT0WU
SF126 NF3RUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DDOGlEPTB;OD60OVk{PiEQvF2= NGDKV4FUSU6JRWK=
LB996-RCC M2PDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC2OlRKSzVyPUiuOVMzPTdizszN M4XNO3NCVkeHUh?=
SKG-IIIa NYL4R|d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T4ZWlEPTB;OD62N|A3QSEQvF2= MkLDV2FPT0WU
NCI-SNU-1 M1nW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnoTWM2OD16Lk[0OlQ{KM7:TR?= NEe4W4xUSU6JRWK=
LB771-HNC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf0TWM2OD16Lk[0Olk3KM7:TR?= MVPTRW5ITVJ?
SCC-4 NVTUUmZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzoTWM2OD16Lk[4NlE6KM7:TR?= NUjzV5RbW0GQR1XS
CAMA-1 NGC2ephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRThwN{exOFYh|ryP MWjTRW5ITVJ?
D-502MG NVfSSItYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jPeGlEPTB;OD63PFYzQSEQvF2= NGH5ZpBUSU6JRWK=
ESS-1 M1yybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\oTWM2OD16Lki4O|A1KM7:TR?= MnznV2FPT0WU
HEC-1 NYjSU41tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XDfWlEPTB;OD64PVg3PiEQvF2= NUjvZWVEW0GQR1XS
NB10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;HRldKSzVyPUmuNFIzOjRizszN MUPTRW5ITVJ?
8505C MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGw[GVKSzVyPUmuNFQzOzJizszN MnjuV2FPT0WU
EFO-27 NEKyc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOxb|Q6UUN3ME25MlE3PDF{IN88US=> MoWzV2FPT0WU
HN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTlwMU[2Nlgh|ryP M4DYWXNCVkeHUh?=
DSH1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXoO2xxUUN3ME25MlIxQDdizszN MlTDV2FPT0WU
NBsusSR NYe4fGc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjaOIlIUUN3ME25MlI4PDB{IN88US=> M3rpdnNCVkeHUh?=
LS-123 M1izcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTlwM{G3OlEh|ryP NEXob|lUSU6JRWK=
SHP-77 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTlwM{m5N|Uh|ryP MWTTRW5ITVJ?
ACN MnizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nkXGlEPTB;OT61N|I4PyEQvF2= MULTRW5ITVJ?
U251 NF3HPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe2OoJWUUN3ME25MlY2PTR2IN88US=> Mk[2V2FPT0WU
A431 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTlwOECyN|gh|ryP NYG4TGFkW0GQR1XS
5637 NHjGUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDie2JKSzVyPUmuPFQ6QDRizszN MXHTRW5ITVJ?
MDA-MB-157 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO0TWM2OD17LkmyPFc5KM7:TR?= NF\5U4hUSU6JRWK=
A101D NIL2VJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfLTWM2OD17Lkm5PVc1KM7:TR?= MUnTRW5ITVJ?
YKG-1 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6emlEPTB;MUCuNlAxPiEQvF2= NUHzfW42W0GQR1XS
LAN-6 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzCTWM2OD1zMD6yNVY1KM7:TR?= MYnTRW5ITVJ?
OVCAR-5 M2LzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n1TmlEPTB;MUCuNlQ{OyEQvF2= NH73ZoVUSU6JRWK=
A549 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTFyLkO5O|Mh|ryP NWXBc2x{W0GQR1XS
no-11 NET3R4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzVTWM2OD1zMD60N|U{KM7:TR?= NXPndItPW0GQR1XS
SF539 M1jGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzUTWM2OD1zMD65NFQyKM7:TR?= NFvObmhUSU6JRWK=
A388 M1jifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTCXoNmUUN3ME2xNU4{QDl5IN88US=> M4nHR3NCVkeHUh?=
DEL M3LHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITQTpVKSzVyPUGxMlQzPCEQvF2= M2PucHNCVkeHUh?=
SW954 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5Z2o{UUN3ME2xNU41PjZ6IN88US=> NIi3XWdUSU6JRWK=
TK10 NH:5[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXrUZlMUUN3ME2xNU42OjdzIN88US=> NGLFRohUSU6JRWK=
SW756 NV;5V2dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFzLkWyPVQh|ryP MoDaV2FPT0WU
PC-3 M3iySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFewUXFKSzVyPUGxMlU4PjRizszN NEXzVnBUSU6JRWK=
ONS-76 NHuyfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfLdGhKSzVyPUGxMlY{PiEQvF2= M{HmRnNCVkeHUh?=
A427 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[5TWM2OD1zMT63NFk{KM7:TR?= MX\TRW5ITVJ?
MEG-01 M3XIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\5NWlEPTB;MUGuO|UxQSEQvF2= MmfzV2FPT0WU
BB30-HNC NH3FPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULFXpFJUUN3ME2xNU44QTh{IN88US=> MYPTRW5ITVJ?
NCI-H1299 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPKTWM2OD1zMT64NFk{KM7:TR?= M1\PTnNCVkeHUh?=
GCT MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXQW5ZFUUN3ME2xNU45OjJ6IN88US=> NGrjeppUSU6JRWK=
D-247MG MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTyTWM2OD1zMT65OlY{KM7:TR?= NGPhU2VUSU6JRWK=
CFPAC-1 NUnWZlQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDqWJpKSzVyPUGxMlk4QDJizszN NHTRSWhUSU6JRWK=
EKVX NX7vWXZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LSVmlEPTB;MUKuNFMyOyEQvF2= NEKyZZBUSU6JRWK=
CAL-51 M3LpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rxemlEPTB;MUKuNFcyPiEQvF2= NYLEWHNRW0GQR1XS
BB49-HNC MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF{LkGxO|ch|ryP MnPhV2FPT0WU
RPMI-7951 NVTvUIl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXpN|VKSzVyPUGyMlE5PTRizszN MU\TRW5ITVJ?
RH-1 NETYVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF{LkKxPFQh|ryP NXzMeGd{W0GQR1XS
BCPAP MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\DT2tXUUN3ME2xNk41PzR7IN88US=> M3ywVHNCVkeHUh?=
GCIY NXfMfod4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTLTWM2OD1zMj61NlA6KM7:TR?= NGjNXFlUSU6JRWK=
KNS-81-FD NEixUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\STWM2OD1zMj61PFY6KM7:TR?= M{ix[XNCVkeHUh?=
KYSE-140 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX4Nlg3UUN3ME2xNk45PTl3IN88US=> MVvTRW5ITVJ?
Ca-Ski NWLMO5FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF{LkmwOFEh|ryP MkH0V2FPT0WU
TGBC1TKB NXXBZmtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF{LkmxNVUh|ryP M2\BXXNCVkeHUh?=
HCC1187 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDKTWM2OD1zMz6xPVEzKM7:TR?= NIPQRXJUSU6JRWK=
SJSA-1 NXfVemE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTF|LkKzNlch|ryP NHS5OG9USU6JRWK=
CTV-1 MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DNdWlEPTB;MUOuN|Q2KM7:TR?= M{C1UHNCVkeHUh?=
WM-115 M3nkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;qXVVKSzVyPUGzMlY1QDNizszN MYTTRW5ITVJ?
CHP-212 NGfEN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfDfmpKSzVyPUGzMlk4OzlizszN M4H6eHNCVkeHUh?=
SCC-15 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr5d2d{UUN3ME2xN{46Pzd3IN88US=> MoLkV2FPT0WU
BPH-1 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF2LkG2OlQh|ryP M2rWSXNCVkeHUh?=
SW780 M3PDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInPZoZKSzVyPUG0MlUxOjVizszN M1HSdHNCVkeHUh?=
NCI-H2291 NHXwNJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTocIRiUUN3ME2xOE42QDd6IN88US=> MUfTRW5ITVJ?
JEG-3 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfWbZlKSzVyPUG0MlY{OjZizszN MV;TRW5ITVJ?
CAL-120 M{W1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LZb2lEPTB;MUSuO|AzPyEQvF2= NI[zXYFUSU6JRWK=
NCI-H23 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nXXWlEPTB;MUSuO|k6PyEQvF2= MXfTRW5ITVJ?
MS-1 M1niRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF2Lkm2NVEh|ryP NYP4ZVREW0GQR1XS
PC-14 NG\RPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF2Lkm2OVQh|ryP M2qyXXNCVkeHUh?=
D-283MED NVOwUXBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF3LkCxNVEh|ryP MnLtV2FPT0WU
OE19 NYDlfZFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF3LkG1OFEh|ryP NUTFR|RWW0GQR1XS
CAS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF3LkSxPFQh|ryP NVPmOJR4W0GQR1XS
NCI-H727 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\XTWM2OD1zNT60NlIyKM7:TR?= NEnpfFBUSU6JRWK=
SiHa NX\2XG1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjINldKSzVyPUG1Mlc2QTRizszN NIjCfYpUSU6JRWK=
BFTC-905 NFrVTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF3Lke2PVQh|ryP MnXzV2FPT0WU
MDA-MB-453 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki5TWM2OD1zNj6xOlQzKM7:TR?= NGjieoNUSU6JRWK=
HuP-T3 NULWWZMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFix[HVKSzVyPUG2MlY{PzNizszN M1LEWXNCVkeHUh?=
SK-LU-1 NXfzRlBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17vb2lEPTB;MU[uOlk2PiEQvF2= MUjTRW5ITVJ?
Detroit562 MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF4LkezNVgh|ryP MlnUV2FPT0WU
HCC1569 NIDjR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF4LkizN|ch|ryP M1PKbXNCVkeHUh?=
SK-MES-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L3WmlEPTB;MU[uPFQyQSEQvF2= NY\rN|ZLW0GQR1XS
BB65-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LSc2lEPTB;MUeuNFQ4QSEQvF2= Ml73V2FPT0WU
LOXIMVI NIrMfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXRVlNqUUN3ME2xO{4xPzB5IN88US=> M{XiWnNCVkeHUh?=
SW1783 NEi1NWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknwTWM2OD1zNz6xNlgh|ryP NXrNR5BnW0GQR1XS
NH-12 NX;IemtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfqfpR6UUN3ME2xO{4{OzB|IN88US=> NYnYUodXW0GQR1XS
UACC-257 NWrQVpJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XldmlEPTB;MUeuOVUyOiEQvF2= NFzXO5NUSU6JRWK=
KOSC-2 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViyc4dLUUN3ME2xO{43PzV5IN88US=> NVvhOYhFW0GQR1XS
KG-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[yfIxKSzVyPUG3MlY6OzdizszN MVfTRW5ITVJ?
M059J MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXKUJpKSzVyPUG3MlcxOyEQvF2= NHfqWIxUSU6JRWK=
MHH-NB-11 M2\xV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDOeZRKSzVyPUG3Mlk3PzNizszN NIm2VW1USU6JRWK=
EW-1 NYPQWW9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rw[GlEPTB;MUiuNVM5OiEQvF2= MWrTRW5ITVJ?
CAL-85-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\jU2JKSzVyPUG4MlI{PTdizszN MlvJV2FPT0WU
639-V Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF6LkOzOVQh|ryP NX\US|lrW0GQR1XS
C32 NVO4[GxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL6dVlKSzVyPUG4MlQ4OjdizszN MV3TRW5ITVJ?
KM-H2 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T4fGlEPTB;MUiuOVI{OiEQvF2= NXnSd2xCW0GQR1XS
A253 MlHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvkcWFKSzVyPUG4MlczQDZizszN MmLTV2FPT0WU
NCI-N87 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF6LkmwNFgh|ryP NXO4b49ZW0GQR1XS
8-MG-BA NIL1S|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX1fFZKSzVyPUG5MlA3PDZizszN MXzTRW5ITVJ?
GI-ME-N NV;vT2VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF7LkG1OFYh|ryP MYDTRW5ITVJ?
8305C M{fKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zhXmlEPTB;MUmuNlI5PiEQvF2= M4O3RnNCVkeHUh?=
TE-8 NVvsNlZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfGeWNKSzVyPUG5MlMxOjRizszN MmTTV2FPT0WU
KYSE-270 NYi4fpltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJyLkCyNVch|ryP NYDWbVM4W0GQR1XS
HL-60 M3iwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLqTWM2OD1{MD6wPVQyKM7:TR?= M{fxdnNCVkeHUh?=
Mo-T MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfHXJNKSzVyPUKwMlE3PjVizszN MlrFV2FPT0WU
NCI-H1355 NIDBNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJyLkOzO|Qh|ryP NWLzSXAxW0GQR1XS
HT-1080 NVLyWHZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y0PWlEPTB;MkCuOVQ6PyEQvF2= NEOxTJJUSU6JRWK=
MIA-PaCa-2 M1:wdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzuW3BKSzVyPUKwMlY5QDNizszN MmHSV2FPT0WU
NCI-H441 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkexTWM2OD1{MD63N|c6KM7:TR?= MmWwV2FPT0WU
LCLC-97TM1 NXSyc2N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXYfIVKSzVyPUKwMlgyOzRizszN NX;LdFlIW0GQR1XS
HT-3 NUfUTXV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJzLkW2N|Eh|ryP NYDYXmxQW0GQR1XS
22RV1 M4rLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDXZ4FKSzVyPUKxMlU3QDVizszN MojUV2FPT0WU
LK-2 NXm2NopTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;SdGlEPTB;MkGuOVk2OyEQvF2= M{jNOHNCVkeHUh?=
CW-2 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJzLk[wOlkh|ryP M{C2SXNCVkeHUh?=
KYSE-510 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXyS|BPUUN3ME2yNU43ODl3IN88US=> MUTTRW5ITVJ?
CGTH-W-1 NX3sR3o4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlniTWM2OD1{MT63NVY3KM7:TR?= NIe4WYFUSU6JRWK=
NCI-H661 NHjDTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrUZ4J5UUN3ME2yNk4xOzRizszN MorTV2FPT0WU
KU-19-19 Ml;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXDTWM2OD1{Mj6xOlk4KM7:TR?= NIjDXIFUSU6JRWK=
NCI-H2122 M1;vc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJ{LkK0N|Ih|ryP NITxem1USU6JRWK=
NCI-H526 NGDOUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHETWM2OD1{Mj6zPFk2KM7:TR?= NEG2[W9USU6JRWK=
NCI-H1650 M4fHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPqcm9VUUN3ME2yNk44PjRizszN MVjTRW5ITVJ?
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HSC-3 MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\UTWM2OD16Mz6zNFcyKM7:TR?= NVrQVYZMW0GQR1XS
HTC-C3 NHzCOpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLJd442UUN3ME24N{41PzB{IN88US=> Ml;wV2FPT0WU
KY821 NUfjeW42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnqcXZKSzVyPUi0MlA5QTJizszN NXHuOo9VW0GQR1XS
DoTc2-4510 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j3OGlEPTB;OESuNlE5PSEQvF2= NWD5bVR3W0GQR1XS
NCI-H1581 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\TVGlEPTB;OEWuOFY1OSEQvF2= M4PlO3NCVkeHUh?=
KARPAS-299 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTh4LkG5O|ch|ryP MWrTRW5ITVJ?
IST-MEL1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTh4Lki4O|Ih|ryP NWnDdpE6W0GQR1XS
KP-N-YS NWK0fmZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTh7LkmwNlgh|ryP M33lUXNCVkeHUh?=
KYSE-410 NVnxXYNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7xUVFKSzVyPUmxMlQxPDJizszN MX;TRW5ITVJ?
TE-10 NXvpfZpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjDZ4M{UUN3ME25NU42PjFzIN88US=> MnXpV2FPT0WU
SK-MEL-1 MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTl{LkmxNFYh|ryP M1XWbXNCVkeHUh?=
COLO-792 NUWxSokxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPoeVVQUUN3ME25OU4zPTZ2IN88US=> MVHTRW5ITVJ?
SCH NGnxdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPoR4VoUUN3ME25Ok4{QDd5IN88US=> NHPUO3BUSU6JRWK=
NCI-H1792 NGnSc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\UdWlEPTB;OU[uPFk6OiEQvF2= MWrTRW5ITVJ?
NCI-H2029 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzTWM2OD17Nj65OVY3KM7:TR?= MYDTRW5ITVJ?
SW684 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTl6Lk[2OVQh|ryP M1nPN3NCVkeHUh?=
NCI-H209 M2L4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFyMD6xNlEh|ryP NV\yT|JWW0GQR1XS
HLE NU\jNIJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTkUFBKSzVyPUGwOU4zQDJizszN NF21[2xUSU6JRWK=
GOTO NEjFXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jFeGlEPTB;MUC3Mlc4PyEQvF2= NX\Wb|lSW0GQR1XS
NCI-H1793 NY\LSm9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DRSWlEPTB;MUC5MlI5KM7:TR?= M1ThdnNCVkeHUh?=
D-392MG NVG0[|VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzXZlRjUUN3ME2xNVcvOzl6IN88US=> MmmxV2FPT0WU
SW1990 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqwNY46UUN3ME2xNlAvQTVzIN88US=> MXnTRW5ITVJ?
ML-2 M2TzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD1zMkGuOlc3KM7:TR?= NHnRcHJUSU6JRWK=
NCI-H2452 NVzjN3FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKzTWM2OD1zMkKuNlEh|ryP NFn0dJlUSU6JRWK=
SK-MEL-30 M2\zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK2Uo9KSzVyPUGyN{4zPDRizszN Ml3OV2FPT0WU
SN12C NUTaXGd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3zOJVFUUN3ME2xNlQvOTd4IN88US=> MlXXV2FPT0WU
NCI-H1770 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn4W|VKSzVyPUGyOU42OTRizszN NEfMXI1USU6JRWK=
SF268 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPYfINKSzVyPUGyOk4yPThizszN Mm\VV2FPT0WU
BALL-1 M2XpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF{Nj6yN{DPxE1? MX7TRW5ITVJ?
COLO-679 NXrtS|NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\UO2hKSzVyPUGyOk44PTNizszN M1y1S3NCVkeHUh?=
A2780 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn3UllKSzVyPUGyPE46QDhizszN Mk\aV2FPT0WU
NCI-H1651 M1W5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXVTWM2OD1zM{GuNlQ{KM7:TR?= NUfZRXVXW0GQR1XS
NCI-H2087 NH2wc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\PSI9{UUN3ME2xN|EvPDh|IN88US=> MmfrV2FPT0WU
U-87-MG NFfxXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF|Mz62NFQh|ryP NEjpWFdUSU6JRWK=
LB2518-MEL Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfkXJZKSzVyPUGzOU46QTNizszN MUXTRW5ITVJ?
HCT-116 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLzTWM2OD1zM{euNlE4KM7:TR?= NUDaR3R1W0GQR1XS
Ca9-22 M{O4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrxTWM2OD1zM{muPFM{KM7:TR?= NEi4dHdUSU6JRWK=
COR-L88 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHs[2FKSzVyPUG0Nk4yPCEQvF2= Ml32V2FPT0WU
CP50-MEL-B NXL0RopsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrLbFFKSzVyPUG0OE42ODFizszN NHzY[WlUSU6JRWK=
OVCAR-8 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzQe4pKSzVyPUG0OU43OzZizszN NUmxNpdZW0GQR1XS
SK-MEL-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\WXWlEPTB;MUS3Mlg4QCEQvF2= MmTDV2FPT0WU
GT3TKB M4\RNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojKTWM2OD1zNEmuPVI5KM7:TR?= M{PtR3NCVkeHUh?=
KYSE-450 NXPDN5BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmixTWM2OD1zNUGuOVM6KM7:TR?= NXziR5Q5W0GQR1XS
CAPAN-1 M3HtUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPSTWM2OD1zNUOuNFY1KM7:TR?= MlvSV2FPT0WU
BEN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\NV4FKSzVyPUG1N{46OjhizszN MlraV2FPT0WU
NCI-H1304 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF3ND62PVQh|ryP NUX1RYloW0GQR1XS
KU812 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPx[WlxUUN3ME2xOVgvPjd2IN88US=> MWHTRW5ITVJ?
Capan-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;BTWM2OD1zNkCuOVU{KM7:TR?= NX62NGtKW0GQR1XS
A673 NWm2TnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF4MT63NFUh|ryP NVjJPGZGW0GQR1XS
SAS MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\3WZlxUUN3ME2xOlIvPjd6IN88US=> NVzTUpVXW0GQR1XS
NY M2[0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i2d2lEPTB;MU[1MlMyPCEQvF2= MVnTRW5ITVJ?
HCE-4 NEDyeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPxcHR{UUN3ME2xOlYvQDR3IN88US=> NGLCR|lUSU6JRWK=
MDA-MB-231 M{fzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fCV2lEPTB;MUe3MlUxOyEQvF2= NGPNbGlUSU6JRWK=
no-10 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF5OD6xN|Qh|ryP Mo\lV2FPT0WU
MZ7-mel MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3UTWM2OD1zN{iuOFY4KM7:TR?= NFvqfIdUSU6JRWK=
NCI-H82 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXwOmZTUUN3ME2xPFAvOTZ3IN88US=> MUDTRW5ITVJ?
CAL-72 NX7M[mxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3yzW2lEPTB;MUi1MlA2PCEQvF2= NVqweo5MW0GQR1XS
NCI-SNU-5 NXHYNYZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF6Nj64OEDPxE1? NIDyTZBUSU6JRWK=
OVCAR-4 Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTnUlJKSzVyPUG4PE4{OzNizszN M{nnenNCVkeHUh?=
SCC-9 NXvJPY1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTpOGJKSzVyPUG5NUDPxE1? NUTZT2JJW0GQR1XS
KYSE-150 M3\XRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf1TWM2OD1zOUGuPFg5KM7:TR?= NYDzdVJNW0GQR1XS
HT-29 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJyMT6yNVIh|ryP NGLSZllUSU6JRWK=
COLO-678 Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jtWGlEPTB;MkCxMlQ2KM7:TR?= M37wOnNCVkeHUh?=
NCI-H650 M{TxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;IcIpNUUN3ME2yNFIvOTB|IN88US=> NV;sSYpSW0GQR1XS
HuCCT1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PqR2lEPTB;MkC0MlIxQCEQvF2= NUfET3JOW0GQR1XS
SW1116 M4Dn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJyNz6wO|ch|ryP NWDYOpQ5W0GQR1XS
DBTRG-05MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\nXmlZUUN3ME2yNFcvQTB7IN88US=> M3foNHNCVkeHUh?=
SW982 M{HUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXNTWM2OD1{MEeuPVQ5KM7:TR?= MXfTRW5ITVJ?
RCM-1 M4PJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fsWmlEPTB;MkG0Mlc3OiEQvF2= MWXTRW5ITVJ?
COLO-320-HSR MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLWTWM2OD1{MU[uNVI2KM7:TR?= NUDodGMzW0GQR1XS
KNS-42 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLSTWM2OD1{MU[uOVc1KM7:TR?= NHTWRYVUSU6JRWK=
C2BBe1 NF\6boFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfFb4FKSzVyPUKzNU46ODVizszN NU\CbWRoW0GQR1XS
CCRF-CEM NXi1RYU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HFbmlEPTB;MkSzMlc6PSEQvF2= M2XSfnNCVkeHUh?=
SH-4 NH3BXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XGc2lEPTB;MkS2MlA6KM7:TR?= MkLqV2FPT0WU
LS-1034 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED0UJdKSzVyPUK0Ok4zPjZizszN MXjTRW5ITVJ?
NCI-H2347 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLwTWM2OD1{NEeuO|E{KM7:TR?= MUfTRW5ITVJ?
RPMI-8866 M3L3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fTdmlEPTB;MkS5MlI4KM7:TR?= MofFV2FPT0WU
GAK MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ3Mz6wNFIh|ryP NWDHeo9GW0GQR1XS
NB6 NHLvV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:5UGlEPTB;MkewMlEh|ryP MYXTRW5ITVJ?
COLO-680N M2DEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jLSGlEPTB;MkeyMlUzPyEQvF2= NVrGWoRyW0GQR1XS
RERF-LC-MS NHXxfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X6VmlEPTB;Mke2MlAxPyEQvF2= NXLVfYxMW0GQR1XS
TGBC11TKB MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ5OD6xO|gh|ryP MUjTRW5ITVJ?
C8166 NWr3[5BXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ5OD61NFYh|ryP NVn1RmpUW0GQR1XS
HDLM-2 M1\6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX0PYpKSzVyPUK5OE41ODlizszN NHXuUoRUSU6JRWK=
IGR-1 NIL5fpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJ7NT62OVkh|ryP NUTzZXVkW0GQR1XS
FADU MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn62TWM2OD1{OUeuOVEh|ryP MoruV2FPT0WU
L-428 M1\Cc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzuTWM2OD1{OUeuOlE3KM7:TR?= MWjTRW5ITVJ?
LU-65 NV7FPJJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fmTGlEPTB;M{C0MlMzKM7:TR?= M2jONXNCVkeHUh?=
HEL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTmTWM2OD1|MEmuPVg{KM7:TR?= MXfTRW5ITVJ?
NCI-H810 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XwOWlEPTB;M{GwMlU4KM7:TR?= NFi2fpRUSU6JRWK=
C3A MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHhU|FUUUN3ME2zNVEvQDB{IN88US=> MkP2V2FPT0WU
NCI-H630 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTNNY5IUUN3ME2zN|IvOjl2IN88US=> NX7M[ZlqW0GQR1XS
KP-N-YN NFLRcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LWVWlEPTB;M{SxMlEzOyEQvF2= NUflO2JmW0GQR1XS
MOLT-13 M17lcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLvOG5KSzVyPUO0Nk4{OjZizszN M4DQcHNCVkeHUh?=
NCI-H1993 M4XmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN2Mj6zOlUh|ryP M1W2ZnNCVkeHUh?=
BE-13 NELvdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DnU2lEPTB;M{S0MlE3PyEQvF2= M{\4OXNCVkeHUh?=
IST-SL1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjmTWM2OD1|NEeuOFAyKM7:TR?= NUHw[ZZpW0GQR1XS
TE-9 M3T1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTN4Mz61PFkh|ryP MYHTRW5ITVJ?
LU-135 NGH3NJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS1TWM2OD1|NkeuNFM2KM7:TR?= MVfTRW5ITVJ?
T84 NX3BfG53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\LR3pKSzVyPUO3OE44OTJizszN MkD1V2FPT0WU
K-562 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W4O2lEPTB;M{izMlM3KM7:TR?= M2LQd3NCVkeHUh?=
SBC-5 NI\hU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTN6Nj65PFUh|ryP NHfQVohUSU6JRWK=
NB17 M3myT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVTGlEPTB;M{myMlU6PiEQvF2= Mmi5V2FPT0WU
NCI-H2052 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN7OD60O|Ih|ryP NYnuS3k3W0GQR1XS
HCC38 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvxWo5WUUN3ME20NFEvPTl|IN88US=> M2rIPHNCVkeHUh?=
NCI-H69 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTR2MT6wPFMh|ryP NUTsUVh[W0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

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Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

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  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A
Smiles Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID