MK-2206 2HCl

For research use only.

Catalog No.S1078

1029 publications

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.

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Selleck's MK-2206 2HCl has been cited by 1029 publications

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NInXT|dEgXSxdH;4bYMhSXO|YYm= MYmzJO69VQ>? M1;kUlczKGh? MVrEUXNQ M3\4[2lvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w NF7yNGczODV5MUC2PS=>
A431 NUjSO5NLU2mwYYPlJGF{e2G7 M4i4VFUh|ryP NIrsRWo2KGh? MlzhSG1UVw>? MkDhV5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs Mk\UNlA2PzFyNkm=
HepG2 MUXDfZRwfG:6aXOgRZN{[Xl? Ml70NVAh|ryP M1zUSlI1KGh? Moi1SG1UVw>? MlrtV4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni M1[0Z|IyOjB3OUK1
Sk-Hep1 NWTyO4xXS3m2b4TvfIlkKEG|c3H5 M1joeFExKM7:TR?= MmfUNlQhcA>? M2jBTWROW09? NFPjUYdU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> MUiyNVIxPTl{NR?=
OCUT1 cells harbored PIK3CA (H1047R+/+) M2rscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz3O4l1OyEQvF2= NHfOVoM2KGR? M1nUV2ROW09? NXzWT49PUUN3ME2wMlE1KM7:TR?= M2HhVVIyOjh7Mk[3
K1 cells harbored PIK3CA (E542K+/+) MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCy[4JuOyEQvF2= NIDoPGI2KGR? MYDEUXNQ M4rGRWlEPTB;MD61NkDPxE1? MkexNlEzQDl{Nke=
FTC133 cells harbored PTEN (allele deletion and R130+) NE\FPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG1UpFxOyEQvF2= NGnjZ2o2KGR? M2LFVGROW09? MX;JR|UxRTBwMUig{txO M1;FbFIyOjh7Mk[3
C643 cells harbored HRAS (G13R+/−) M{j1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSzJO69VQ>? NYnVfmVCPSCm MXTEUXNQ NX\DNZNYUUN3ME2wMlI4KM7:TR?= M{LKbFIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) NUG2b|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2zJO69VQ>? MYe1JIQ> NEHTWFhFVVOR NI\WeFJKSzVyPUSuOUDPxE1? NIrYS4gzOTJ6OUK2Oy=>
TPC1 cells harbored RET/PTC1 rearrangement M{XqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\OflMh|ryP MYC1JIQ> MoDGSG1UVw>? MkT3TWM2OD1yLkW5JO69VQ>? MVmyNVI5QTJ4Nx?=
Hth74 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[zJO69VQ>? Ml3rOUBl M{P5W2ROW09? M336W2lEPTB;Mj6xPUDPxE1? NGn2ZWszOTJ6OUK2Oy=>
KAT18 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKyWVQ{KM7:TR?= M13NNFUh\A>? NUfYW5U1TE2VTx?= Mnq2TWM2OD12Lk[yJO69VQ>? MXOyNVI5QTJ4Nx?=
SW1736 M{D3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPEUXcyODBizszN M{LoUlUh\A>? NFq4eo1FVVOR NV7Ib4hIUUN3ME20O{42PiEQvF2= NHnX[HUzOTJ6OUK2Oy=>
WRO MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2yNVAxOCEQvF2= MWG1JIQ> M2jrWmROW09? M{LNN2lEPTB-MUCwNEDPxE1? NFW0PIIzOTJ6OUK2Oy=>
TAD2 M2r5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXZNVAxOCEQvF2= NHHEOXI2KGR? NGriNlNFVVOR NVq1OGI2UUN3ME6xNFAxKM7:TR?= MmT0NlEzQDl{Nke=
LN229 MVrBdI9xfG:|aYOgRZN{[Xl? NYn0c4JxOC53IN88US=> MmLtOlAhcA>? MUXEUXNQ MlH2RZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? MoW2NlIxPTd7MUS=
T98G NWPpd41LSXCxcITvd4l{KEG|c3H5 MWSwMlUh|ryP NEW3SZg3OCCq Ml2zSG1UVw>? M3;tU2F2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk MWqyNlA2PzlzNB?=
HC11 MV7GeY5kfGmxbjDBd5NigQ>? MoLBNVAh|ryP MXiyOEBp MUnEUXNQ NVPQVXAzUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? M2TsWVIzPDJ4NkKx
MOLT-4 M4r5V2N6fG:2b4jpZ{BCe3OjeR?= NGnheHUyOCEQvF2= MnT6OFghcA>? MlnjSG1UVw>? MlzRTWM2OD1zLkhihKnPxE1? NELqSZozOjZzNEK0Ny=>
CEM-R MVXDfZRwfG:6aXOgRZN{[Xl? MmXzNVAh|ryP M{\ndFQ5KGh? NEjKWlFFVVOR NIPXV2VKSzVyPUOuN-KBkc7:TR?= MkfzNlI3OTR{NEO=
CEM-S NH3jOotEgXSxdH;4bYMhSXO|YYm= M4HLPVExKM7:TR?= NH7rTpc1QCCq NWPGOY9jTE2VTx?= M{LqZ2lEPTB;NT6x5qCK|ryP MoW5NlI3OTR{NEO=
MOLT-4 NVrkVVA6TnWwY4Tpc44hSXO|YYm= NHXIXWUyOCEQvF2= NFfZPY8zPCCq MnTGSG1UVw>? MWLCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm NV;nPWY3OjJ4MUSyOFM>
MOLT-4 MoPYSpVv[3Srb36gRZN{[Xl? MnLHOQKBkc7:TR?= NVLYbnl6PCCq NHznbYVFVVOR M3HpbGlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFOzRU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? MnTtNlI3OTR{NEO=
CEM-R MlTTSpVv[3Srb36gRZN{[Xl? NGSxWHY16oDLzszN MX60JIg> MmHnSG1UVw>? MnrjTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{TBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz MYSyNlYyPDJ2Mx?=
CEM-S NH\SWnBHfW6ldHnvckBCe3OjeR?= MUm05qCK|ryP M{\FflQhcA>? NH;YPXBFVVOR NV70S|dsUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|VCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ NHX0bYgzOjZzNEK0Ny=>
HepG2 cell MoPGT4lv[XOnIFHzd4F6 NUf3WWYxOjBizszN MlziNlQhcA>? M1PMNWROW09? MlLDSI94dnKnZ4XsZZRmeyC2aHWgdIhwe3Cqb4L5cIF1cW:wIH;mJGFMXA>? NUjuNmt6OjN5OUezNVk>
HepG2 cell NWPlRWJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fMNFMxKM7:TR?= M4Pa[lI1KGh? M3TqTmROW09? MV;Jcohq[mm2czDj[YxtKGe{b4f0bC=> MmXTNlM4QTd|MUm=
HepG2 cell NYfnb2ltSXCxcITvd4l{KEG|c3H5 MkfnNlAh|ryP NUTPbFd[OjRiaB?= MkK2SG1UVw>? MWLJcoR2[2W|IHPlcIwh[XCxcITvd4l{ M4jWblI{Pzl5M{G5
GEO NHPYS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPzPIE2ODBibl2= M{\WTlczKGh? MYPEUXNQ MVLJcohq[mm2czDj[YxtKGe{b4f0bC=> MkL3NlQ2QDF{M{G=
CNE-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvCNVAh|ryP M2Dy[lk3KGh? MlqySG1UVw>? NH75UIRKSzVyPUKuPVYh|ryP MkfuNlU{OzZ7MkW=
CNE-2 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf2ZngyOCEQvF2= MnnxPVYhcA>? NXjuSWNDTE2VTx?= M2rYUWlEPTB;ND61N{DPxE1? MWKyOVM{Pjl{NR?=
HONE-1 NFOxfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjVNVAh|ryP MlzUPVYhcA>? MkLvSG1UVw>? NXHmbWRXUUN3ME2zMlM4KM7:TR?= MkTrNlU{OzZ7MkW=
SUNE-1 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nYc|ExKM7:TR?= Mnu1PVYhcA>? NFKydHNFVVOR NXHyXXhnUUN3ME2wMlUzKM7:TR?= MXeyOVM{Pjl{NR?=
CNE-2 Mlm1SpVv[3Srb36gRZN{[Xl? M3WxfVExKM7:TR?= MljROFghcA>? NHPpc2FFVVOR NFPTfFNKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz MWOyOVM{Pjl{NR?=
HONE-1 MnHWSpVv[3Srb36gRZN{[Xl? M1TVblExKM7:TR?= M2PKUlQ5KGh? MYnEUXNQ M4\u[2lv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? NY\TcmhkOjV|M{[5NlU>
NEC8 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEm2OVEh|ryP MmXlV2FPT0WU
P12-ICHIKAWA M4\6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjnTWM2OD1yLkGxOlIh|ryP NUfGSXZLW0GQR1XS
MDA-MB-175-VII MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DCPWlEPTB;MD6xN|c{QCEQvF2= NXq4Z4VxW0GQR1XS
AsPC-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH2NXZ1UUN3ME2wMlIzOTJ{IN88US=> NWWyPWVyW0GQR1XS
T47D M3HwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\WT2lEPTB;MD6yPFI2KM7:TR?= Ml3uV2FPT0WU
HH M{fte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwM{CyPFMh|ryP MoK1V2FPT0WU
MOLT-16 M3L1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXl[GpKSzVyPUCuN|A{OiEQvF2= M4jlb3NCVkeHUh?=
ES5 NI[3NWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3F[VB6UUN3ME2wMlM1PDV3IN88US=> MXjTRW5ITVJ?
RS4-11 NFr4VmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DEV2lEPTB;MD6zOFYyKM7:TR?= MUHTRW5ITVJ?
KARPAS-45 M1jjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzSUY5KSzVyPUCuN|c{OjFizszN MnruV2FPT0WU
NCI-H720 NX3hZXFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTiOo5uUUN3ME2wMlM4Pjd7IN88US=> MULTRW5ITVJ?
H9 NH:xcYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjCdWNKSzVyPUCuN|g5QDNizszN M1HjcnNCVkeHUh?=
EFM-19 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6z[pFJUUN3ME2wMlQ1ODFizszN MkOyV2FPT0WU
SBC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvSTWM2OD1yLkS0NFM2KM7:TR?= MoPtV2FPT0WU
A4-Fuk M3K1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwNE[4Olgh|ryP NHPjbGRUSU6JRWK=
NCI-H1563 NFjjSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:4PHRKSzVyPUCuOFgyQDlizszN MmjGV2FPT0WU
HCC1419 M4XEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vkXmlEPTB;MD60PFg6OiEQvF2= MoLtV2FPT0WU
H-EMC-SS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nicGlEPTB;MD60PVk{QSEQvF2= MXLTRW5ITVJ?
BHT-101 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLxWmNKSzVyPUCuOVI6PjFizszN NHPuOHJUSU6JRWK=
IGROV-1 M4PtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnITWM2OD1yLkW1NlQ6KM7:TR?= NFyyUIxUSU6JRWK=
HGC-27 NIS2cVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvNc|VKSzVyPUCuOVY4QDNizszN MnnDV2FPT0WU
MDA-MB-361 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNUe3OlEh|ryP NH3u[GpUSU6JRWK=
KE-37 NXHsSmloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\LZmlEPTB;MD61PFI3KM7:TR?= MkTxV2FPT0WU
HCC70 MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT3ZnQ{UUN3ME2wMlU6QDJ5IN88US=> M13oPHNCVkeHUh?=
LNCaP-Clone-FGC NIDH[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNkGwOFgh|ryP NX7xXWlJW0GQR1XS
HAL-01 Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;wV4F1UUN3ME2wMlYzOTNizszN NY\De4JnW0GQR1XS
HT NWG4bIVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwNkOyN|kh|ryP MkPNV2FPT0WU
MDA-MB-415 MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHJSGdTUUN3ME2wMlY{PjJ4IN88US=> NFrqXGFUSU6JRWK=
NOS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zQemlEPTB;MD62N|czOyEQvF2= MmLKV2FPT0WU
DU-145 M4C0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILGPHNKSzVyPUCuOlQ4PDVizszN M4ThNXNCVkeHUh?=
OCUB-M NWPQTHBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDKSXVwUUN3ME2wMlcxQTZ4IN88US=> NIDETVlUSU6JRWK=
VA-ES-BJ NI[y[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwN{OwNlUh|ryP NIe0SVRUSU6JRWK=
J-RT3-T3-5 NHzKdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H3XWlEPTB;MD63OFQxOyEQvF2= Mnm2V2FPT0WU
MOLT-4 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;zTWM2OD1yLkiwOVgzKM7:TR?= M3rKenNCVkeHUh?=
NB7 M{\IWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXDN5JKSzVyPUCuPFI1OTFizszN MYnTRW5ITVJ?
L-363 NFzHe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW0TWM2OD1yLkizOFQzKM7:TR?= Ml3mV2FPT0WU
NKM-1 M1rvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z1SGlEPTB;MD64OlI2OyEQvF2= NWLtbJJoW0GQR1XS
HOP-92 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnDU25KSzVyPUCuPFczOjNizszN NEOweWFUSU6JRWK=
OAW-42 M17RNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3SbXlQUUN3ME2wMlg5PzJizszN NXjrfGpPW0GQR1XS
HuO9 NUPwdIZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{frdWlEPTB;MD65Nlc2OSEQvF2= M3z0[XNCVkeHUh?=
MFE-280 NW\EXHRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzFTWM2OD1yLkm2OFY2KM7:TR?= NIn4cmxUSU6JRWK=
EM-2 NGDDfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy0NmxKSzVyPUCuPVc6OzlizszN NF7KZ2RUSU6JRWK=
NCI-H520 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7xTWM2OD1yLkm4OVkzKM7:TR?= MojTV2FPT0WU
LB2241-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{mwOmlEPTB;MD65PVc{PCEQvF2= MX3TRW5ITVJ?
SK-NEP-1 NG\udHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTtTWM2OD1zLkG0OFg2KM7:TR?= MoDBV2FPT0WU
LXF-289 M1XMdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzuPJZKSzVyPUGuNVcyPTZizszN MVTTRW5ITVJ?
EPLC-272H NGHKdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwMUeyOVYh|ryP M3q2bnNCVkeHUh?=
COLO-684 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LMbGlEPTB;MT6yN|czPSEQvF2= Mn7ZV2FPT0WU
ES1 NEH1OW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwMkSwOlUh|ryP MYfTRW5ITVJ?
DOHH-2 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\xTWM2OD1zLkK4NlA{KM7:TR?= M37yWXNCVkeHUh?=
CTB-1 M{DGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTqc|JjUUN3ME2xMlI5QTlizszN MUDTRW5ITVJ?
G-401 M{P0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli5TWM2OD1zLkK5O|k2KM7:TR?= M4fodnNCVkeHUh?=
LoVo MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTFwM{K1N|Qh|ryP M4PsVXNCVkeHUh?=
Ramos-2G6-4C10 M2\2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe2ZotKSzVyPUGuN|M4ODFizszN MkSyV2FPT0WU
MFM-223 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjmbo1FUUN3ME2xMlM1PDZzIN88US=> NUDzcmVyW0GQR1XS
PA-1 M2jlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT2OIRXUUN3ME2xMlM2OjZ3IN88US=> MoPaV2FPT0WU
697 NWDZcJFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLTUlVKSzVyPUGuN|c3OTZizszN MoPzV2FPT0WU
QIMR-WIL MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ucopKSzVyPUGuOFkyOTZizszN M{\Fd3NCVkeHUh?=
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MHH-PREB-1 NXvTeGRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHNTWM2OD1|LkeyNFM5KM7:TR?= MU\TRW5ITVJ?
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SCC-25 NY\vbpRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\ETJlSUUN3ME20MlA3PTZ4IN88US=> M{OzXXNCVkeHUh?=
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KLE M{W4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfnO4NoUUN3ME20MlcxOTl6IN88US=> MnqyV2FPT0WU
CAL-39 M1:2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjGTm5QUUN3ME20MlczOTR4IN88US=> Mni2V2FPT0WU
TI-73 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fOTGlEPTB;ND64NFYxQSEQvF2= MUfTRW5ITVJ?
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786-0 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPTN4prUUN3ME20Mlk1Pjd|IN88US=> NYPJN3Q1W0GQR1XS
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NCI-H446 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;LZ2NKSzVyPUWuNlAxODlizszN NYPRS2luW0GQR1XS
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BT-20 MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTVwMkGzOVMh|ryP M3;GenNCVkeHUh?=
MEL-HO M{TuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTVwM{ezN|Yh|ryP Mnr5V2FPT0WU
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D-263MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTZwNEWxOlkh|ryP M1m5UHNCVkeHUh?=
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TE-6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXLTWM2OD14LkmzNFM5KM7:TR?= MXTTRW5ITVJ?
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NCI-H28 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PzZWlEPTB;Nz6yPVI1KM7:TR?= NW\QboFWW0GQR1XS
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SF126 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRThwNEW5N|Yh|ryP MXfTRW5ITVJ?
LB996-RCC Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfqZ5R4UUN3ME24MlU{OjV5IN88US=> M1XFRXNCVkeHUh?=
SKG-IIIa MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRThwNkOwOlkh|ryP MXXTRW5ITVJ?
NCI-SNU-1 NWXUdJRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRThwNkS2OFMh|ryP MXvTRW5ITVJ?
LB771-HNC NVLKUnVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fhXGlEPTB;OD62OFY6PiEQvF2= MUnTRW5ITVJ?
SCC-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\KTWM2OD16Lk[4NlE6KM7:TR?= M3fadXNCVkeHUh?=
CAMA-1 MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRThwN{exOFYh|ryP NVnqWpV2W0GQR1XS
D-502MG NFe4TItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOxeldKSzVyPUiuO|g3OjlizszN MVLTRW5ITVJ?
ESS-1 M3S4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nfWZuUUN3ME24Mlg5PzB2IN88US=> NFyxW3pUSU6JRWK=
HEC-1 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLUXVV{UUN3ME24Mlg6QDZ4IN88US=> MYnTRW5ITVJ?
NB10 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTlwMEKyNlQh|ryP NH[5dHNUSU6JRWK=
8505C MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLhXVRKSzVyPUmuNFQzOzJizszN NYjYfphLW0GQR1XS
EFO-27 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTlwMU[0NVIh|ryP NGG5RlBUSU6JRWK=
HN MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\Uc|ZPUUN3ME25MlE3PjJ6IN88US=> MXfTRW5ITVJ?
DSH1 NILWN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nhUGlEPTB;OT6yNFg4KM7:TR?= MY\TRW5ITVJ?
NBsusSR MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHrUJVWUUN3ME25MlI4PDB{IN88US=> M2HmXXNCVkeHUh?=
LS-123 NGe4UXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTlwM{G3OlEh|ryP MlW4V2FPT0WU
SHP-77 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTlwM{m5N|Uh|ryP MV3TRW5ITVJ?
ACN NFTKcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TsXWlEPTB;OT61N|I4PyEQvF2= NYTsb|RUW0GQR1XS
U251 M4K4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr4TWM2OD17Lk[1OVQ1KM7:TR?= MmL0V2FPT0WU
A431 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfpbJFKSzVyPUmuPFAzOzhizszN MYTTRW5ITVJ?
5637 NF3mUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\CTGlEPTB;OT64OFk5PCEQvF2= MVnTRW5ITVJ?
MDA-MB-157 NH;LNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT0SlhZUUN3ME25MlkzQDd6IN88US=> NYfQfVdjW0GQR1XS
A101D MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknJTWM2OD17Lkm5PVc1KM7:TR?= M2DMN3NCVkeHUh?=
YKG-1 NIPVVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34[GJKSzVyPUGwMlIxODZizszN M4\sXnNCVkeHUh?=
LAN-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[xTmlEPTB;MUCuNlE3PCEQvF2= NHXmflZUSU6JRWK=
OVCAR-5 NHHMUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXzc49TUUN3ME2xNE4zPDN|IN88US=> MkfrV2FPT0WU
A549 M{TyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFyLkO5O|Mh|ryP NFLCRZFUSU6JRWK=
no-11 NXXUepluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HFSWlEPTB;MUCuOFM2OyEQvF2= MYLTRW5ITVJ?
SF539 M1jMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnuZ2RIUUN3ME2xNE46ODRzIN88US=> M{PwcnNCVkeHUh?=
A388 NInEemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\rXZZxUUN3ME2xNU4{QDl5IN88US=> MkDCV2FPT0WU
DEL NVTxbpNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33ldGlEPTB;MUGuOFI1KM7:TR?= M4jkV3NCVkeHUh?=
SW954 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrqeFFqUUN3ME2xNU41PjZ6IN88US=> NUXWd2FmW0GQR1XS
TK10 NHjDcFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTFzLkWyO|Eh|ryP Mn\VV2FPT0WU
SW756 NU[0SooyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37X[WlEPTB;MUGuOVI6PCEQvF2= NUKzWXJRW0GQR1XS
PC-3 NFKzcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITa[mtKSzVyPUGxMlU4PjRizszN NX7RTnRZW0GQR1XS
ONS-76 NVv0[XdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXWTWM2OD1zMT62N|Yh|ryP NVLQZ4hSW0GQR1XS
A427 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle0TWM2OD1zMT63NFk{KM7:TR?= MnnuV2FPT0WU
MEG-01 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3dGlEPTB;MUGuO|UxQSEQvF2= MWTTRW5ITVJ?
BB30-HNC NEPSOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnVSnRKSzVyPUGxMlc6QDJizszN MknvV2FPT0WU
NCI-H1299 NEfYZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1[o1YUUN3ME2xNU45ODl|IN88US=> MWHTRW5ITVJ?
GCT MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFzLkiyNlgh|ryP NELEUpNUSU6JRWK=
D-247MG MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXqTWM2OD1zMT65OlY{KM7:TR?= M2\NXnNCVkeHUh?=
CFPAC-1 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELLOHBKSzVyPUGxMlk4QDJizszN NFzaPXhUSU6JRWK=
EKVX NIftNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjYe2RKSzVyPUGyMlA{OTNizszN MVzTRW5ITVJ?
CAL-51 M4\xNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjTR|dKSzVyPUGyMlA4OTZizszN NI\IXGFUSU6JRWK=
BB49-HNC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfLWZhKSzVyPUGyMlEyPzdizszN M2qx[3NCVkeHUh?=
RPMI-7951 NIPifHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M361dGlEPTB;MUKuNVg2PCEQvF2= MnrMV2FPT0WU
RH-1 NUPmc3FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF{LkKxPFQh|ryP MVzTRW5ITVJ?
BCPAP M1vXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHKbVZKSzVyPUGyMlQ4PDlizszN MVLTRW5ITVJ?
GCIY NIDZXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPheoZKSzVyPUGyMlUzODlizszN MVPTRW5ITVJ?
KNS-81-FD NFm4W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf4TWM2OD1zMj61PFY6KM7:TR?= NGfIOGJUSU6JRWK=
KYSE-140 NXz0U5pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm1Sld4UUN3ME2xNk45PTl3IN88US=> M2LCWHNCVkeHUh?=
Ca-Ski NIjVe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxdoNkUUN3ME2xNk46ODRzIN88US=> M{fMRXNCVkeHUh?=
TGBC1TKB MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\tR4tZUUN3ME2xNk46OTF3IN88US=> MWXTRW5ITVJ?
HCC1187 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFWwcI9KSzVyPUGzMlE6OTJizszN MmTsV2FPT0WU
SJSA-1 NWTvepNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPZNGdKSzVyPUGzMlI{OjdizszN M{LNbXNCVkeHUh?=
CTV-1 M3XTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHPb3FVUUN3ME2xN{4{PDVizszN MoDiV2FPT0WU
WM-115 NITlcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW5XXU4UUN3ME2xN{43PDh|IN88US=> NYLFc2R[W0GQR1XS
CHP-212 NIrCVphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK4e3BKSzVyPUGzMlk4OzlizszN NGHsPWhUSU6JRWK=
SCC-15 NFm1TYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrFUHdEUUN3ME2xN{46Pzd3IN88US=> NEnLemlUSU6JRWK=
BPH-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfMTWM2OD1zND6xOlY1KM7:TR?= MWfTRW5ITVJ?
SW780 NVLvdmt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\zUXdKSzVyPUG0MlUxOjVizszN NFPFWJdUSU6JRWK=
NCI-H2291 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF2LkW4O|gh|ryP MXzTRW5ITVJ?
JEG-3 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF2Lk[zNlYh|ryP NYXmfWtIW0GQR1XS
CAL-120 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfHO2c{UUN3ME2xOE44ODJ5IN88US=> NXHX[G12W0GQR1XS
NCI-H23 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF2Lke5PVch|ryP MmTtV2FPT0WU
MS-1 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4eWlEPTB;MUSuPVYyOSEQvF2= MYfTRW5ITVJ?
PC-14 MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrrRldnUUN3ME2xOE46PjV2IN88US=> Mnu0V2FPT0WU
D-283MED M4jmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfVcGVxUUN3ME2xOU4xOTFzIN88US=> MVXTRW5ITVJ?
OE19 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF3LkG1OFEh|ryP NEjTSJhUSU6JRWK=
CAS-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fqb2lEPTB;MUWuOFE5PCEQvF2= NEDqT|JUSU6JRWK=
NCI-H727 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF3LkSyNlEh|ryP MlSwV2FPT0WU
SiHa NHPqTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF3Lke1PVQh|ryP MXrTRW5ITVJ?
BFTC-905 NXK3W3Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDwelYzUUN3ME2xOU44Pjl2IN88US=> NXzYNZF7W0GQR1XS
MDA-MB-453 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj2TWM2OD1zNj6xOlQzKM7:TR?= Mn3NV2FPT0WU
HuP-T3 NI\OfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfyXlBKSzVyPUG2MlY{PzNizszN NITlcFZUSU6JRWK=
SK-LU-1 NGL1U3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K0cWlEPTB;MU[uOlk2PiEQvF2= NEnvcIlUSU6JRWK=
Detroit562 M1LZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF4LkezNVgh|ryP NXvyUGpMW0GQR1XS
HCC1569 Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF4LkizN|ch|ryP MXPTRW5ITVJ?
SK-MES-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPlZ4RyUUN3ME2xOk45PDF7IN88US=> MnfiV2FPT0WU
BB65-RCC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC1TWM2OD1zNz6wOFc6KM7:TR?= MUPTRW5ITVJ?
LOXIMVI NXvCW2t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Kze2lEPTB;MUeuNFcxPyEQvF2= M4nhXXNCVkeHUh?=
SW1783 M{LUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHoTWM2OD1zNz6xNlgh|ryP MkXGV2FPT0WU
NH-12 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnLWIszUUN3ME2xO{4{OzB|IN88US=> NX3PcVhPW0GQR1XS
UACC-257 M3LlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\KU2ZKSzVyPUG3MlU2OTJizszN MmrPV2FPT0WU
KOSC-2 NGD6XHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF5Lk[3OVch|ryP M2f6O3NCVkeHUh?=
KG-1 NF7lNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF5Lk[5N|ch|ryP MmXFV2FPT0WU
M059J MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\vfVJKSzVyPUG3MlcxOyEQvF2= M1rTU3NCVkeHUh?=
MHH-NB-11 NXXqOlRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF5Lkm2O|Mh|ryP NGjRS25USU6JRWK=
EW-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELSXWZKSzVyPUG4MlE{QDJizszN NVS2XGl5W0GQR1XS
CAL-85-1 NYnmTmxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTF6LkKzOVch|ryP MUDTRW5ITVJ?
639-V Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13teWlEPTB;MUiuN|M2PCEQvF2= M2jOZ3NCVkeHUh?=
C32 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF6LkS3Nlch|ryP MnO5V2FPT0WU
KM-H2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV75PYZ1UUN3ME2xPE42OjN{IN88US=> NVHNPZd[W0GQR1XS
A253 NFHPSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OxOmlEPTB;MUiuO|I5PiEQvF2= MUDTRW5ITVJ?
NCI-N87 M3TQW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDXTWM2OD1zOD65NFA5KM7:TR?= MYnTRW5ITVJ?
8-MG-BA MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DR[WlEPTB;MUmuNFY1PiEQvF2= MnjWV2FPT0WU
GI-ME-N MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL0dGlLUUN3ME2xPU4yPTR4IN88US=> NYjl[FJlW0GQR1XS
8305C MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzvTWM2OD1zOT6yNlg3KM7:TR?= NXn4ZZVZW0GQR1XS
TE-8 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\kTWM2OD1zOT6zNFI1KM7:TR?= M3\YRnNCVkeHUh?=
KYSE-270 NULOXmd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjlUJpqUUN3ME2yNE4xOjF5IN88US=> NGmzeo1USU6JRWK=
HL-60 NHy2VnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJyLkC5OFEh|ryP MV3TRW5ITVJ?
Mo-T NXTqS|N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJyLkG2OlUh|ryP NXjGUHo{W0GQR1XS
NCI-H1355 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SwemlEPTB;MkCuN|M4PCEQvF2= MkG5V2FPT0WU
HT-1080 NGrGbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDqRoVzUUN3ME2yNE42PDl5IN88US=> MUHTRW5ITVJ?
MIA-PaCa-2 NVviUoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJyLk[4PFMh|ryP M{TkUnNCVkeHUh?=
NCI-H441 NYLkZZV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH4NY1KSzVyPUKwMlc{PzlizszN NHq4U3dUSU6JRWK=
LCLC-97TM1 M{LQWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPRTWM2OD1{MD64NVM1KM7:TR?= NXjpe|RvW0GQR1XS
HT-3 NVz6SYE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPwTWM2OD1{MT61OlMyKM7:TR?= MVvTRW5ITVJ?
22RV1 MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXlTWM2OD1{MT61Olg2KM7:TR?= MnfwV2FPT0WU
LK-2 M37ZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXyXVI6UUN3ME2yNU42QTV|IN88US=> M2rsUHNCVkeHUh?=
CW-2 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXyPXNKSzVyPUKxMlYxPjlizszN Ml;BV2FPT0WU
KYSE-510 NFHlNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnaRnkyUUN3ME2yNU43ODl3IN88US=> NYq3SFQ2W0GQR1XS
CGTH-W-1 NFLxXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTqNWRKSzVyPUKxMlcyPjZizszN MY\TRW5ITVJ?
NCI-H661 M{f3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfsTWM2OD1{Mj6wN|Qh|ryP MXnTRW5ITVJ?
KU-19-19 M3v0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[ybmlEPTB;MkKuNVY6PyEQvF2= MmDsV2FPT0WU
NCI-H2122 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi0dW5lUUN3ME2yNk4zPDN{IN88US=> MYPTRW5ITVJ?
NCI-H526 M1qzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJ{LkO4PVUh|ryP NUe3eVlxW0GQR1XS
NCI-H1650 M2j1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXUfmZ4UUN3ME2yNk44PjRizszN NFTr[FhUSU6JRWK=
AM-38 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PjeWlEPTB;MkKuPFY5QSEQvF2= M{nOVXNCVkeHUh?=
NCI-H2405 NXfk[VU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTmT5FvUUN3ME2yN{4zPTN|IN88US=> NGDEZVVUSU6JRWK=
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KY821 NWC2O2NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL1Om1KSzVyPUi0MlA5QTJizszN M4G2OXNCVkeHUh?=
DoTc2-4510 NYLkUZNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTh2LkKxPFUh|ryP MmrGV2FPT0WU
NCI-H1581 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XJTGlEPTB;OEWuOFY1OSEQvF2= NGf5Z3hUSU6JRWK=
KARPAS-299 NF[2OFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX2PJFKSzVyPUi2MlE6PzdizszN NYK1c2ZxW0GQR1XS
IST-MEL1 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTh4Lki4O|Ih|ryP M4Had3NCVkeHUh?=
KP-N-YS NXO4W3V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jQeWlEPTB;OEmuPVAzQCEQvF2= MVHTRW5ITVJ?
KYSE-410 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn3OVk1UUN3ME25NU41ODR{IN88US=> NHLMO2JUSU6JRWK=
TE-10 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r1[GlEPTB;OUGuOVYyOSEQvF2= MXPTRW5ITVJ?
SK-MEL-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLuOmdTUUN3ME25Nk46OTB4IN88US=> NELOe4tUSU6JRWK=
COLO-792 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\KTWM2OD17NT6yOVY1KM7:TR?= MnHkV2FPT0WU
SCH MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTl4LkO4O|ch|ryP MXzTRW5ITVJ?
NCI-H1792 MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzETWM2OD17Nj64PVkzKM7:TR?= MWLTRW5ITVJ?
NCI-H2029 NIDlc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTSdVUzUUN3ME25Ok46PTZ4IN88US=> M1;HSXNCVkeHUh?=
SW684 NFPQd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnjTWM2OD17OD62OlU1KM7:TR?= MV;TRW5ITVJ?
NCI-H209 NFvxTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fjXGlEPTB;MUCwMlEzOSEQvF2= NVroNnFMW0GQR1XS
HLE MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFyNT6yPFIh|ryP NVy5WXJ3W0GQR1XS
GOTO NUfZfWRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInucGZKSzVyPUGwO{44PzdizszN MlrSV2FPT0WU
NCI-H1793 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml74TWM2OD1zMEmuNlgh|ryP MoPpV2FPT0WU
D-392MG NYDlXWtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELneVFKSzVyPUGxO{4{QThizszN NH76XGdUSU6JRWK=
SW1990 M3fwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv4SI1zUUN3ME2xNlAvQTVzIN88US=> NI\VNmFUSU6JRWK=
ML-2 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHLTWM2OD1zMkGuOlc3KM7:TR?= MWfTRW5ITVJ?
NCI-H2452 NWj4OYszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDmWWFKSzVyPUGyNk4zOSEQvF2= MXXTRW5ITVJ?
SK-MEL-30 MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF{Mz6yOFQh|ryP MWrTRW5ITVJ?
SN12C M3e2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF{ND6xO|Yh|ryP M2O0OXNCVkeHUh?=
NCI-H1770 M2LuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{NT61NVQh|ryP MVfTRW5ITVJ?
SF268 NFfLWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\XTWM2OD1zMk[uNVU5KM7:TR?= Mn7OV2FPT0WU
BALL-1 NWmwWW1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHZTFVKSzVyPUGyOk4zOyEQvF2= MVnTRW5ITVJ?
COLO-679 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLDTWM2OD1zMk[uO|U{KM7:TR?= M2jzR3NCVkeHUh?=
A2780 NEDLOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHUdVN[UUN3ME2xNlgvQTh6IN88US=> MlHoV2FPT0WU
NCI-H1651 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDFUHRKSzVyPUGzNU4zPDNizszN NYfNOohqW0GQR1XS
NCI-H2087 NGPBbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTF|MT60PFMh|ryP NY\GWJNPW0GQR1XS
U-87-MG M3fVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjITWM2OD1zM{OuOlA1KM7:TR?= MWHTRW5ITVJ?
LB2518-MEL NIPoN3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF|NT65PVMh|ryP MXXTRW5ITVJ?
HCT-116 M4HEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LGVmlEPTB;MUO3MlIyPyEQvF2= NF\LdmVUSU6JRWK=
Ca9-22 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLPTWM2OD1zM{muPFM{KM7:TR?= MY\TRW5ITVJ?
COR-L88 NIOyU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF2Mj6xOEDPxE1? NYjQN4xWW0GQR1XS
CP50-MEL-B NUTxXGFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi4SpRFUUN3ME2xOFQvPTBzIN88US=> MVXTRW5ITVJ?
OVCAR-8 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF2NT62N|Yh|ryP MmLOV2FPT0WU
SK-MEL-3 M2DDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nDTGlEPTB;MUS3Mlg4QCEQvF2= MlTPV2FPT0WU
GT3TKB NUi1V2R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\pTWM2OD1zNEmuPVI5KM7:TR?= M17rR3NCVkeHUh?=
KYSE-450 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTF3MT61N|kh|ryP MUDTRW5ITVJ?
CAPAN-1 M{DTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF3Mz6wOlQh|ryP NXHBfVZPW0GQR1XS
BEN NWn1OmJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLjbYJKSzVyPUG1N{46OjhizszN Mly4V2FPT0WU
NCI-H1304 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmxTWM2OD1zNUSuOlk1KM7:TR?= NWTJWIlQW0GQR1XS
KU812 NXTSTI1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTTWlJKSzVyPUG1PE43PzRizszN MYPTRW5ITVJ?
Capan-2 NHi5dZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn3VHpkUUN3ME2xOlAvPTV|IN88US=> M2HmWnNCVkeHUh?=
A673 NGjVVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHniXJVKSzVyPUG2NU44ODVizszN NWfXfmMzW0GQR1XS
SAS M2S0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHqOWZKSzVyPUG2Nk43PzhizszN MWLTRW5ITVJ?
NY MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjRSYlKUUN3ME2xOlUvOzF2IN88US=> M1zScnNCVkeHUh?=
HCE-4 M4fnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PZbGlEPTB;MU[2Mlg1PSEQvF2= M2nrRXNCVkeHUh?=
MDA-MB-231 M3rOSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnNZnpkUUN3ME2xO|cvPTB|IN88US=> MoLlV2FPT0WU
no-10 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33reWlEPTB;MUe4MlE{PCEQvF2= M2WxN3NCVkeHUh?=
MZ7-mel NEjh[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX23NYt2UUN3ME2xO|gvPDZ5IN88US=> MofLV2FPT0WU
NCI-H82 M{f2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHPTWM2OD1zOECuNVY2KM7:TR?= MVHTRW5ITVJ?
CAL-72 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP4TWM2OD1zOEWuNFU1KM7:TR?= M3e2fnNCVkeHUh?=
NCI-SNU-5 NYKzZpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjXT5BOUUN3ME2xPFYvQDRizszN MUPTRW5ITVJ?
OVCAR-4 Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7CW4RJUUN3ME2xPFgvOzN|IN88US=> NVnSSmlXW0GQR1XS
SCC-9 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLxWJVKSzVyPUG5NUDPxE1? MXPTRW5ITVJ?
KYSE-150 NXLvUnh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;FT5RNUUN3ME2xPVEvQDh6IN88US=> NIHzZlRUSU6JRWK=
HT-29 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fhOGlEPTB;MkCxMlIyOiEQvF2= NH;J[G9USU6JRWK=
COLO-678 NV\OOIlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv4W2p1UUN3ME2yNFEvPDVizszN NFLkPJdUSU6JRWK=
NCI-H650 NFrMd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHOTWM2OD1{MEKuNVA{KM7:TR?= NWfLcpJGW0GQR1XS
HuCCT1 NHLNdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3P[2tKSzVyPUKwOE4zODhizszN MnfNV2FPT0WU
SW1116 M3jPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\PeZVVUUN3ME2yNFcvODd5IN88US=> M3rWVnNCVkeHUh?=
DBTRG-05MG NGPx[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vnPGlEPTB;MkC3MlkxQSEQvF2= NUHuc5A{W0GQR1XS
SW982 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJyNz65OFgh|ryP NEXFO4FUSU6JRWK=
RCM-1 MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofsTWM2OD1{MUSuO|YzKM7:TR?= NHu3SFlUSU6JRWK=
COLO-320-HSR NEHvXpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjwR4pKSzVyPUKxOk4yOjVizszN NVK5O|ZzW0GQR1XS
KNS-42 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJzNj61O|Qh|ryP NIntZ4tUSU6JRWK=
C2BBe1 NYDTZXNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\lTWM2OD1{M{GuPVA2KM7:TR?= MVvTRW5ITVJ?
CCRF-CEM MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjxSJltUUN3ME2yOFMvPzl3IN88US=> NX30SYtYW0GQR1XS
SH-4 NYrufndTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XCOmlEPTB;MkS2MlA6KM7:TR?= M2O0[nNCVkeHUh?=
LS-1034 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XQcWlEPTB;MkS2MlI3PiEQvF2= MnriV2FPT0WU
NCI-H2347 NFzFVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j1cmlEPTB;MkS3MlcyOyEQvF2= NHXhTXJUSU6JRWK=
RPMI-8866 M3KySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\FOYpVUUN3ME2yOFkvOjdizszN MlfZV2FPT0WU
GAK NYj5VYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ3Mz6wNFIh|ryP M2H2SXNCVkeHUh?=
NB6 NYjIVo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD2TWM2OD1{N{CuNUDPxE1? MVXTRW5ITVJ?
COLO-680N NEDCeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjrUZhKSzVyPUK3Nk42OjdizszN M1fRe3NCVkeHUh?=
RERF-LC-MS NE\3b3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Hz[2lEPTB;Mke2MlAxPyEQvF2= NGXI[ZlUSU6JRWK=
TGBC11TKB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJ5OD6xO|gh|ryP NUTxOFlNW0GQR1XS
C8166 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ5OD61NFYh|ryP M1zYPXNCVkeHUh?=
HDLM-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3uRpdWUUN3ME2yPVQvPDB7IN88US=> MVPTRW5ITVJ?
IGR-1 M2PLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTJ7NT62OVkh|ryP MV3TRW5ITVJ?
FADU NWrFOol3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTWTWM2OD1{OUeuOVEh|ryP NGTNR|hUSU6JRWK=
L-428 MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\Xb3BKSzVyPUK5O{43OTZizszN NGfHc2RUSU6JRWK=
LU-65 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTITWM2OD1|MESuN|Ih|ryP MoDHV2FPT0WU
HEL M{G0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTDTWM2OD1|MEmuPVg{KM7:TR?= MlizV2FPT0WU
NCI-H810 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTNzMD61O{DPxE1? M4TCNXNCVkeHUh?=
C3A NWnVbY1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvJR3JQUUN3ME2zNVEvQDB{IN88US=> M1fFPXNCVkeHUh?=
NCI-H630 Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XEN2lEPTB;M{OyMlI6PCEQvF2= M3ThWHNCVkeHUh?=
KP-N-YN MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnOSWN4UUN3ME2zOFEvOTJ|IN88US=> MXjTRW5ITVJ?
MOLT-13 NUHwOpppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN2Mj6zNlYh|ryP MmLaV2FPT0WU
NCI-H1993 NEDOWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTN2Mj6zOlUh|ryP NGHGR2xUSU6JRWK=
BE-13 NXraUoVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInhUVFKSzVyPUO0OE4yPjdizszN NHWyfGJUSU6JRWK=
IST-SL1 NXexRmxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN2Nz60NFEh|ryP NWLQ[otnW0GQR1XS
TE-9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHXTWM2OD1|NkOuOVg6KM7:TR?= M3LRVnNCVkeHUh?=
LU-135 NYLkXnMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3rTWM2OD1|NkeuNFM2KM7:TR?= NHe4bpFUSU6JRWK=
T84 NEjwT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN5ND63NVIh|ryP NV7iT5EyW0GQR1XS
K-562 M3vEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq1TWM2OD1|OEOuN|Yh|ryP NVTHSZp6W0GQR1XS
SBC-5 M{TCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe4RlRtUUN3ME2zPFYvQTh3IN88US=> M1vibHNCVkeHUh?=
NB17 M4S2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K4WGlEPTB;M{myMlU6PiEQvF2= NHS1bohUSU6JRWK=
NCI-H2052 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzLVGtKSzVyPUO5PE41PzJizszN NFP6NpFUSU6JRWK=
HCC38 Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LNeGlEPTB;NECxMlU6OyEQvF2= MVHTRW5ITVJ?
NCI-H69 M1\hfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDJepZiUUN3ME20OFEvODh|IN88US=> NULES4h1W0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1; 

PubMed: 22932669     


ZR75-1 cells were treated with MK-2206 150 nmol/L and collected after indicated hours. Akt signaling was assessed by Western blotting. 

22932669
Growth inhibition assay
Cell viability; 

PubMed: 24665203     


(A) MK-2206 reduced the viability of anaplastic thyroid carcinoma (ATC) cells. CAL62 and KAT4 cells were treated with MK-2206 for 72 hours, followed by measurement with a cell viability assay. (B) In vitro cell viability assay of combination with MK-2206 and tyrphostin AG 1296 in KAT4 cells. 

24665203
Immunofluorescence
LC3; 

PubMed: 24490764     


Immunofluorescence staining of LC3A (green) and DAPI (blue) in M368 cells following treatment with either MK-2206, Carboplatin and Paclitaxel or the combination of all three agents for 72h.

CFTR/LC3; 

PubMed: 28794469     


Co-localisation of CFTR (red- 549nm) and LC3 (green- 488nm) in ΔF508 CFBE41o- cells treated with MK-2206 and a negative control CFBE41o- cells at 37 ℃. Nuclei were stained with DAPI (blue- 358nm). Scale bar is 10 µm.

HMGA2; 

PubMed: 24476133     


Immunofluorescent staining for HMGA2 of leiomyoma cells in control and MK-2206-treated cells was done. Cells were costained with DAPI. Immunointensity of HMGA2 expression was measured and calculated. *, P < .05; **, P < .01; ***, P < .001.

24490764 28794469 24476133
ELISA
VEGFA; 

PubMed: 29449553     


VEGF-A protein expression of conditioned medium was determined by ELISA in cervical cancer cells. The results were analyzed using one-way ANOVA. Column, mean (n = 3); bars, SD. **P < 0.01, compared with control. ##P < 0.01, compared with NF90.

29449553
In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

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Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

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  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A
Smiles Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting Drug: Akt Inhibitor MK2206|Drug: Hydroxychloroquine Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01466868 Terminated Drug: MK2206 Diffuse Large B Cell Lymphoma Centre Leon Berard|National Cancer Institute France November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID