MK-2206 2HCl

Catalog No.S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

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Cited by 183 Publications

21 Customer Reviews

  • Inhibition of AKT signaling abolishes MKK4 phosphorylation on Ser78 in injured axons. Cultures of sensory neurons were treated with 5 µM MK-2206 or 5 µM GDC-0068 for 1 hr prior to axotomy. Axonal proteins harvested at indicated time points after axotomy were subjected to immunoblot analysis.

    Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck.

    j,k, Gene expression ofMYOCD (j) and ACTA2 ( SMA, k) after applying inhibitors of key components involved in the DDR2 downstream signalling pathway to HSCs cultured within 3D collagen matrix subjected to stretching (ST) (n=3, one-way ANOVA, **P=0.0036, ****P<0.0001). l,m, Expression of SMA was significantly reduced after treatment with related inhibitors in early-stage FμNs. (n=4, one-way ANOVA, ***P=0.001, ****P<0.0001). AKT-i: MK-2206

    Nature Materials, 2017, 16:1252-1261.. MK-2206 2HCl purchased from Selleck.

  • The PI3K or AKT inhibition does not restore sensitivity to WZ4002 in PC9 WZR. PC9GR4 or WZR10 cells were treated with WZ4002 alone at the indicated concentrations or in combination with the AKT inhibitor MK-2206 (1 uM). MK-2206 effectively inhibited AKT in both cells.

    Cancer Discov 2012 2, 934-47. MK-2206 2HCl purchased from Selleck.

    Cancer Cell 2013 24, 766-76. MK-2206 2HCl purchased from Selleck.

  • VE-cadherin-induced Akt activation mediates YAP phosphorylation and translocation in ECs. HUVECs were starved for 1h and treated with thrombin (1U) for 1h. Total cell lysates were probed with anti-pAkt, Akt or b-actin antibody. The representative blots of three independent experiments are depicted, and the normalized values for p-Akt are shown. HUVECs were cultured and starved as described as in d and incubated for 8h in complete medium with the Akt inhibitor, MK-2206 (1 uM). pAkt, Akt, pYAP and YAP were detected by western blotting using specific antibodies.

    Nat Commun 2015 6:6943. MK-2206 2HCl purchased from Selleck.

    Rap1b negatively regulates neutrophil transcellular migration by limiting PI3K-Akt signaling. (A-D) Effect of Akt inhibitor MK2206 (2 uM), Src inhibitor PP2 (10 uM), or vehicle control (DMSO) on WT or Rap1b-/- neutrophil functions. (A) Percentage of neutrophil transendothelial migration in 3D migration model. (B) ECM degradation assessed on Oregon green-labeled gelatin matrix; (left) representative images on (bar, 10 um) and (right) bar graph is percentage of matrix degradation. (C) Percentage of cells forming multiple protrusions. (D) Percentage of neutrophils present at junction of activated bEND.3 in 3D migration assay. Mean ?SD; n = 3 independent experiments. **, P < 0.01; ***, P < 0.001; NS, not significant using unpaired Student's t test).

    J Exp Med 2014 211(9), 1741-58. MK-2206 2HCl purchased from Selleck.

  • Inhibitors of AKT or ERK overcome SDF-1a-mediated resistance to ibrutinib-triggered PARP and caspase 3 cleavage in CXCR4S338X-expressing BCWM.1 cells. CXCR4S338X-expressing WM cells were treated with ibrutinib (0.5 uM) alone or in the presence of SDF-1a (20 nM) and/or the AKT inhibitors MK-2206 (0.5 uM) and AZD-5363 (0.5 uM); or the MEK inhibitors AS-703026 (0.25 uM), AZD-6244 (0.5 uM) and UO126 (5.0 uM). (a) Immunoblotting results for phosphoAKT (S473) and phospho-ERK (T202/Y204) in CXCR4S338X-expressing BCWM.1 cells pretreated with ibrutinib with and without AKT or ERK inhibitors, then subjected to SDF-1a stimulation for 2 min. The inhibitory effect of AZD-5363 on AKT, which is known to paradoxically hyper-phosphorylate pAKT(S473) was confirmed by inhibition of the phospho-activity for the downstream AKT targets glycogen synthase kinase 3b and pS6. (b) Immunoblotting results for cleaved PARP and cleaved caspase 3 in CXCR4S338X-expressing BCWM.1 cells treated with ibrutinib and/or AKT or ERK inhibitors for 6 h at IC50 doses. GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

    Leukemia 2015 29(1), 169-76. MK-2206 2HCl purchased from Selleck.

    Induction of apoptosis positively correlates with FOXO3a protein levels and phosphorylation. (a) Treatment of 11 cell lines seeded in 6-well plates with 8 μM MK-2206 or DMSO for 48 hours. Nuclei were harvested for PI staining and FACS analysis and the differences between drug and no drug are displayed as in Figure b. Both conditions were performed in triplo for each cell line. Below the FACS data is a we stern blot of cell lysates from this panel treated with 8 μM MK-2206 or DMSO and harvested at 24 hours. Each cell line name corresponds to the two western lanes below it and the four cell cycle bars above it.

    Cancer Res 2013 73, 2189-98. MK-2206 2HCl purchased from Selleck.

  • Mean IL-8 concentrations determined by ELISA of the supernatants of HeLa cells infected with wild-type Salmonella. Kinase inhibitors are indicated on the x axis, and the target families of the inhibitors are indicated above each column. CEC, chelerythrine; Pim Inh, Pim-1 inhibitor 2. Inhibitors that significantly affected IL-8 production relative to the control (P < 0.05, Bonferroni post hoc test from one-way ANOVA) are indicated with an asterisk. Relative cell viability is also shown, as determined by reduction of XTT by viable cells. A450, absorbance at 450 nm.

    Sci Signal 2011 4, rs9. MK-2206 2HCl purchased from Selleck.

    Reducing cellular levels of PtdIns5P by overexpression of PIP4Kα inhibits clonogenic growth of U2OS but enhances cell survival in response to H2O2 stimulation. A) U2OS cells (1000) were plated, allowed to attach overnight, and then treated with DMSO (control), PI-103 (0.5 μM), U0126 (5 μM), or SB203580 (5 μM) for 9 d. Cell colonies were stained using crystal violet. Dried plates were scanned. Representative results are shown. B) U2OS cells (1000) were plated, allowed to attach overnight, and then treated with DMSO (control), MK-2206 (1 μM), triciribine (1 μM), KU0063794 (1 μM), or PI-103 (0.5 μM) for 9 d. Cell colonies were stained using crystal violet. Dried plates were scanned. Representative results are shown.

    FASEB J 2013 27, 1644-56. MK-2206 2HCl purchased from Selleck.

  • A. Western blot analysis of pAKT activation in ovarian cancer cell lines treated with exogenous IGF-1. B. Activation of pAKT by IGF-1 in low-grade ovarian cancer cell lines was blocked by the AKT inhibitor MK-2206 in a dose-dependent manner.

    Gynecol Oncol 2011 123, 13-8. MK-2206 2HCl purchased from Selleck.

    Comparative effects of inhibitors by immunofluorescence microscopy study. Confluent HC11 cells were grown on poly-L-lysine-coated glass coverslips (immunofluorescence) and on plastic plates (biochemical control) and then treated with inhibitors according to the standard procedure. Upper part: the biochemical action of the inhibitors was tested to validate the immunofluorescence results. Cellular proteins were analyzed by SDS-PAGE and the immunoblots were successively probed with anti-ADRP, anti-β-casein, and anti- β-actin antibodies and their respective HRP-conjugated secondary antibodies. Each experimental condition was performed in duplicate. Lower part: cells were fixed, permeabilized and subjected to immunofluorescence microscopy using antiserum against ADRP and TRITC-conjugated secondary antibody (red).

    Biochim Biophys Acta 2012 1823, 987-96. MK-2206 2HCl purchased from Selleck.

  • Confocal microscopy images of NO formation. DAF 2 DA-loaded washed platelets (1.0109 platelets/mL) were preincubated at 378C with saline (A), and then stimulated for 1min with 0.1 (B), 1.0 (C) or 10 (D) μM AEA. In Panel (E-F-G) washed platelets were preincubated with 1 μM SR1 (E), 1 Mm MK2206 (F) or 20 μM LY294002 (G), and then stimulated for 1min with 1.0 μM AEA. In panel (H) is reported the effect of 5 mg/mL collagen, used as a positive control. All the experiments were carried out in the presence of 100 μM L-arginine. NO formation was visualized by confocal microscropy as detailed in Methods.

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

    The AEA effect on eNOS phosphorylation. Washed platelets (1.0109 platelets/mL), preincubated at 378C with saline, 1 μM SR1, 1 μM SR2, 20 μM LY294002, 1 μM MK2206, 1.0 μM EGTA, or 30 μM BAPTA/AM, were stimulated for 1 min with 1.0 μM AEA. At the end of incubation suitable aliquots were immunoblotted with anti-p-eNOSser1177 as detailed in Methods.Blots are representative of five independent experiments.

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

  • Effect of selected agents on NOx and cGMP formation induced by AEA. Washed platelets (1.0109 platelets/mL), prewarmed at 378C with saline or 1mM SR1, 1 μM SR2, 20 μM URB597 (URB), 1 μM MK2206 (MK) or 20 μM LY294002 (LY), were incubated for 1min with 100 μM L-arginine in the presence of 1.0 μM AEA. NOx (panel A) and cGMP (panel B) content were determined as detailed in Methods. Each bar represents the meanSD of five independent experiments carried out in triplicate. Student,s t-test: P <0.0001 versus none;P <0.0005; P <0.005 versus AEA

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

    C.U87MG cells were treated with vehicle or 1 μM MK-2206 for 1 hr, and then irradiated with 6 Gy. Total cell lysate was harvested 1 hr after IR and subjected to Western blot analysis with the indicated antibody. Cells without IR treatment were used as a control.

    D. Cells were treated with vehicle (control) or 1 μM MK-2206 for 1 hr, then irradiated with indicated dosage. 4 hr after IR, cells were fed with drug-free medium, and incubated for another 20 hr at 37°C, after which they were trypsinized and seeded for clonogenic survival assay. Colony-forming efficiency was determined 14 d later.
     

     

    Radiat Oncol 2009 4, 43. MK-2206 2HCl purchased from Selleck.

  • (B) Dose-response curves for DIPG 4 and SF7761 cells treated with the small molecule AKT inhibitor MK-2206 (error bars represent SEM).

    Oncol Rep, 2018, 39(2):455-464. MK-2206 2HCl purchased from Selleck.

    MK-2206 2HCL inhibited the sorafenib-induced PI3K/mTOR pathway activation and enhanced the cytotoxic effects of sorafenib in resistant cell lines. (A) HUH-7 hepatoma cells treated with sorafenib (5 μM) for 24 h with or without pretreatment with specific kinase inhibitors (MK-2206 2HCL, 15 μM). The expressions of p-AKT and cleaved PARP were revealed by Western blotting. (B) SK-HEP-1 hepatoma cells treated with sorafenib (5 μM) for 24 h with or without pretreatment with specific kinase inhibitors (MK-2206 2HCL, 15 μM). The expressions of p-AKT and cleaved RARP were revealed by Western blotting. (C) HUH-7 hepatoma cells treated with sorafenib (5 μM) with or without the kinase inhibitors for 24 h. The proportions of apoptotic cells were evaluated by annexin V labeling. (D) SK-HEP-1 hepatoma cells treated with sorafenib (5 μM) with or without the kinase inhibitors for 24 h. The proportions of apoptotic cells were evaluated by annexin V labeling. (*P < 0.05, HUH-7, SK-HEP-1 are control groups, R-HUH-7, R-SK-HEP-1 are resistant groups).

    J Surg Res, 2016, 206(2):371-379. MK-2206 2HCl purchased from Selleck.

  • IC50 values for an Akt inhibitor (MK-2206) and a MEK inhibitor (U0126) in a panel of mouse and human anaplastic (ATC) and follicular (FTC) carcinoma cell lines. On the bottom, a Western blotting showing the effect on the activation of Akt and ERK1/2 of one hour exposure to these inhibitors (MK-2206: 500 nM, U0126: 10 μM).

    Oncotarget 2011 2, 1109-26. MK-2206 2HCl purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of MK-2206 for 3h,followed by 15-minute stimolation of 100ng/ml EGF.

     
     

     

    Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck.

  •  

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    MK-2206 2HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Features The first allosteric small molecule inhibitor of Akt to enter clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NH3GRYpEgXSxdH;4bYMhSXO|YYm= NXTzeFZnOyEQvF2= NHz4Z|M4OiCq MVHEUXNQ MWTJcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdg>? MmW2NlA2PzFyNkm=
A431 MknXT4lv[XOnIFHzd4F6 NHnJRYU2KM7:TR?= MmjIOUBp M4ruXmROW09? NHrGNoVUfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? M4LiSlIxPTdzME[5
HepG2 NXmx[4w1S3m2b4TvfIlkKEG|c3H5 M1jYfVExKM7:TR?= Mon6NlQhcA>? MVXEUXNQ NHiyZXVU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> MWqyNVIxPTl{NR?=
Sk-Hep1 NFu5dWlEgXSxdH;4bYMhSXO|YYm= NXuzT|lmOTBizszN MXyyOEBp M4H5cWROW09? MofpV4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni MlmyNlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) MmiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH4N{DPxE1? MnG4OUBl M3XBc2ROW09? NFjuTlJKSzVyPUCuNVQh|ryP MkHCNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) NV3MNmZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvwN{DPxE1? MWe1JIQ> NUTCfnRMTE2VTx?= MkX6TWM2OD1yLkWyJO69VQ>? NGfVSpEzOTJ6OUK2Oy=>
FTC133 cells harbored PTEN (allele deletion and R130+) NHK5[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL1[|kxOyEQvF2= MWC1JIQ> MVHEUXNQ NWroXmJWUUN3ME2wMlE5KM7:TR?= MlTFNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) M3;FNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L0R|Mh|ryP NE\BVnE2KGR? NGX1NVNFVVOR MlzNTWM2OD1yLkK3JO69VQ>? NEfN[m0zOTJ6OUK2Oy=>
Hth7 cells harbored NRAS (Q61R+/−) NWnKeldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Z[FJMOyEQvF2= M4TBfVUh\A>? NVnsUJBSTE2VTx?= NUPCVGs1UUN3ME20MlUh|ryP Ml3MNlEzQDl{Nke=
TPC1 cells harbored RET/PTC1 rearrangement MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M360SlMh|ryP NHLrZ2U2KGR? M33nemROW09? MUDJR|UxRTBwNUmg{txO MmjyNlEzQDl{Nke=
Hth74 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXGzJO69VQ>? M1u0VlUh\A>? NG\EcZJFVVOR M3jIbGlEPTB;Mj6xPUDPxE1? MnzVNlEzQDl{Nke=
KAT18 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;QT|Mh|ryP MWC1JIQ> MlXUSG1UVw>? M3raemlEPTB;ND62NkDPxE1? NWf0TYlpOjF{OEmyOlc>
SW1736 M1\mTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkntNVAxKM7:TR?= NXjMcJRkPSCm MoHwSG1UVw>? NVm4bYk1UUN3ME20O{42PiEQvF2= MWCyNVI5QTJ4Nx?=
WRO M{HuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES3S5MyODByIN88US=> MVq1JIQ> NYOzXXJWTE2VTx?= NIrwRYhKSzVyPkGwNFAh|ryP NXXEUmM6OjF{OEmyOlc>
TAD2 NEflcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq4b5NlOTByMDFOwG0> MmHiOUBl MXfEUXNQ NETUdW9KSzVyPkGwNFAh|ryP NYrhXI1OOjF{OEmyOlc>
LN229 MYjBdI9xfG:|aYOgRZN{[Xl? MlTPNE42KM7:TR?= MorvOlAhcA>? NYC1Ums{TE2VTx?= Moe5RZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? M3m5ZVIzODV5OUG0
T98G M2HsU2Fxd3C2b4Ppd{BCe3OjeR?= MmT6NE42KM7:TR?= M1P6O|YxKGh? NFO5NplFVVOR NWrRUo85SXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= M{[4SFIzODV5OUG0
HC11 MXvGeY5kfGmxbjDBd5NigQ>? NWrrcXVZOTBizszN NXLJdZZ4OjRiaB?= MljCSG1UVw>? MkP5TY5pcWKrdIOg{tIu[2G|ZXnuJIFv\CCDRGLQJJN6dnSqZYPpdy=> M3ewOVIzPDJ4NkKx
MOLT-4 NVLmeI1RS3m2b4TvfIlkKEG|c3H5 MYqxNEDPxE1? MVS0PEBp Mn3mSG1UVw>? M3X3c2lEPTB;MT635qCK|ryP NIe4[4YzOjZzNEK0Ny=>
CEM-R NFm1bJREgXSxdH;4bYMhSXO|YYm= M{HYflExKM7:TR?= MkP6OFghcA>? NX\vVItxTE2VTx?= NH:5OXdKSzVyPUOuN-KBkc7:TR?= NUn0boliOjJ4MUSyOFM>
CEM-S NHHsWlhEgXSxdH;4bYMhSXO|YYm= MXSxNEDPxE1? NYD4dolDPDhiaB?= M1G3OGROW09? MXvJR|UxRTVwMfMAje69VQ>? NUThT25mOjJ4MUSyOFM>
MOLT-4 M4C3OmZ2dmO2aX;uJGF{e2G7 MWqxNEDPxE1? MoLBNlQhcA>? NX3rUnk{TE2VTx?= MVTCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm MoLqNlI3OTR{NEO=
MOLT-4 NIW5d|BHfW6ldHnvckBCe3OjeR?= MorqOQKBkc7:TR?= MUK0JIg> MnXMSG1UVw>? M2LDTGlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFOzRU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NVS0T|V7OjJ4MUSyOFM>
CEM-R MVHGeY5kfGmxbjDBd5NigQ>? NGqwdZk16oDLzszN NWmwdJFzPCCq MXLEUXNQ MmixTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{TBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz NFPZc4EzOjZzNEK0Ny=>
CEM-S MXPGeY5kfGmxbjDBd5NigQ>? M{L0[FTjiIoQvF2= NFX2[XY1KGh? NELxXGFFVVOR NIHHW2ZKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOWEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? M4rSbVIzPjF2MkSz
HepG2 cell Mn;aT4lv[XOnIFHzd4F6 MmDINlAh|ryP NESx[YwzPCCq NVHxSFN2TE2VTx?= MU\Ec5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[gRWtV M4\peVI{Pzl5M{G5
HepG2 cell NVXXSmhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXn[3E{OCEQvF2= NHP4V4gzPCCq NY\5TIJUTE2VTx?= NIGzTodKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MmXBNlM4QTd|MUm=
HepG2 cell NFzZXHVCeG:ydH;zbZMhSXO|YYm= MnXGNlAh|ryP M1jwOFI1KGh? NX3jb5ZJTE2VTx?= MUDJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NFLmSIIzOzd7N{OxPS=>
GEO NXfPOZhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzTOVAxKG6P M{O2SVczKGh? MYXEUXNQ NIq2UnpKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NF\jepEzPDV6MUKzNS=>
CNE-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[xNEDPxE1? NYHmbHpQQTZiaB?= NHHUcI1FVVOR NWLOe4pMUUN3ME2yMlk3KM7:TR?= M4rCcVI2OzN4OUK1
CNE-2 Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jaOlExKM7:TR?= M1[xNFk3KGh? MX3EUXNQ M1HKV2lEPTB;ND61N{DPxE1? MVOyOVM{Pjl{NR?=
HONE-1 NFfydlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\PN|MyOTBizszN MnT0PVYhcA>? M3HTcWROW09? NYPGd5BVUUN3ME2zMlM4KM7:TR?= M17tVVI2OzN4OUK1
SUNE-1 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHDNVAh|ryP M2nkXlk3KGh? MXHEUXNQ NIDUVZRKSzVyPUCuOVIh|ryP MlS3NlU{OzZ7MkW=
CNE-2 NHT5W5BHfW6ldHnvckBCe3OjeR?= MYGxNEDPxE1? NE[1WXk1QCCq NEjSfW5FVVOR NXPUfpRZUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= MYeyOVM{Pjl{NR?=
HONE-1 MXfGeY5kfGmxbjDBd5NigQ>? NYr5RpdGOTBizszN NGPUWVg1QCCq MlnJSG1UVw>? NEiwSodKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz MonvNlU{OzZ7MkW=
NEC8 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rzd2lEPTB;MD6wPVY2OSEQvF2= NWrLepB4W0GQR1XS
P12-ICHIKAWA NGnOUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOxO3VKSzVyPUCuNVE3OiEQvF2= NELvZo9USU6JRWK=
MDA-MB-175-VII MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm0[|BKSzVyPUCuNVM4OzhizszN NX7u[2U2W0GQR1XS
AsPC-1 M4jaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLBZWpKSzVyPUCuNlIyOjJizszN NEGwco1USU6JRWK=
T47D M{LjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rHcGlEPTB;MD6yPFI2KM7:TR?= MkH1V2FPT0WU
HH Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEK5eW1KSzVyPUCuN|AzQDNizszN NE\jZYRUSU6JRWK=
MOLT-16 NHfsRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjuR3ZYUUN3ME2wMlMxOzJizszN MV\TRW5ITVJ?
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RPMI-8226 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTHWlVKUUN3ME2yMlYzQTV|IN88US=> NE\0S29USU6JRWK=
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NCI-H1048 NHLyZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz4XYNVUUN3ME2yMlk3QDZ3IN88US=> M33yenNCVkeHUh?=
GR-ST MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjwc5hYUUN3ME2zMlA1PjFzIN88US=> NFnITXJUSU6JRWK=
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Calu-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16yRWlEPTB;ND6yOFQyPiEQvF2= NFe0fHJUSU6JRWK=
NCI-H460 NELrVlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRwMk[0OFMh|ryP NUTENYU5W0GQR1XS
EGI-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jURWlEPTB;ND6zO|c4QCEQvF2= M2Lzd3NCVkeHUh?=
NCI-H292 M2LuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\3TWM2OD12LkO4NVQ3KM7:TR?= NVTVSms4W0GQR1XS
HCE-T NYC4dm1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\oUWlEPTB;ND60NVU4QSEQvF2= MVjTRW5ITVJ?
EW-11 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LFcGlEPTB;ND60NVg{QCEQvF2= NVvpbIhNW0GQR1XS
ATN-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonJTWM2OD12LkS0N|A1KM7:TR?= NWrld4N1W0GQR1XS
NB5 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwNUO2PVch|ryP NFXteYZUSU6JRWK=
KLE MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRwN{CxPVgh|ryP NGDafVBUSU6JRWK=
CAL-39 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TJZWlEPTB;ND63NlE1PiEQvF2= MnfwV2FPT0WU
TI-73 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe1TWM2OD12LkiwOlA6KM7:TR?= M37xR3NCVkeHUh?=
HO-1-N-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHxW|Z{UUN3ME20Mlk1OiEQvF2= NVzuVIN7W0GQR1XS
786-0 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHQTWM2OD12Lkm0Olc{KM7:TR?= Mnu2V2FPT0WU
SK-N-DZ M3\2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfRTWM2OD12Lkm2NVQzKM7:TR?= MlvLV2FPT0WU
NCI-H446 NYjLOll5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\WTWM2OD13LkKwNFA6KM7:TR?= NU\MbWJzW0GQR1XS
ETK-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLqTWM2OD13LkKxNVY2KM7:TR?= M1noenNCVkeHUh?=
BT-20 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXUNo1KSzVyPUWuNlE{PTNizszN Mo\ZV2FPT0WU
MEL-HO Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvWTmRKSzVyPUWuN|c{OzZizszN NF;ENIJUSU6JRWK=
CAL-27 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;DV2lEPTB;NT60OlM{QSEQvF2= NWrEPVY1W0GQR1XS
SW872 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrBbmFFUUN3ME21MlU6PDJ6IN88US=> NYrsfHM1W0GQR1XS
RPMI-2650 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTVwNk[xPVkh|ryP MYnTRW5ITVJ?
PFSK-1 NYrhd29{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwN{K3N|Ih|ryP M3vZbXNCVkeHUh?=
SF295 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTVwOEC2N|Mh|ryP MkO4V2FPT0WU
Becker MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTVwOE[0O|Ih|ryP NXzDUZg3W0GQR1XS
Saos-2 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjyWVJKSzVyPUWuPFY2OyEQvF2= NEi2eHBUSU6JRWK=
SK-OV-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7oNpJKSzVyPUWuPVk5OTZizszN M37iWnNCVkeHUh?=
VMRC-RCZ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X0bWlEPTB;Nj6wPFc4OyEQvF2= MlvxV2FPT0WU
EW-22 M{XR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnibnZXUUN3ME22MlE6PjR7IN88US=> M321UHNCVkeHUh?=
BT-474 M1[zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT6TWM2OD14LkKzN{DPxE1? Ml;2V2FPT0WU
BFTC-909 NVj0[FZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILaTJZKSzVyPU[uN|A{PDVizszN M2LVTXNCVkeHUh?=
NB12 NFzabWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTZwM{mwO|Eh|ryP MljFV2FPT0WU
D-263MG M3q4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXBd5VKSzVyPU[uOFUyPjlizszN MVjTRW5ITVJ?
SNB75 NV7N[FdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTZwNkCxOFMh|ryP NUjTU2xtW0GQR1XS
A704 M{\wTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PUbmlEPTB;Nj62N|A3KM7:TR?= NXPEV4RZW0GQR1XS
NCI-H1693 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL3VG96UUN3ME22MlY{PjB2IN88US=> NITwdW5USU6JRWK=
LN-405 M{DESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW1[W5KSzVyPU[uO|k3PzJizszN Mk\QV2FPT0WU
CHL-1 M3Xqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTZwOECwO|kh|ryP Mm\YV2FPT0WU
A498 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnBUVBHUUN3ME22MlgyQTZzIN88US=> MmWzV2FPT0WU
TE-12 M3\R[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPKTWM2OD14LkizPFE4KM7:TR?= NY\UTIo5W0GQR1XS
TE-6 NGTxZ4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\pNmlEPTB;Nj65N|A{QCEQvF2= MmjlV2FPT0WU
AU565 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnJT4xKSzVyPU[uPVY6PTdizszN M33LSHNCVkeHUh?=
RD MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z5b2lEPTB;Nj65PFI5PCEQvF2= MlPPV2FPT0WU
SW1463 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTdwMUGxOlgh|ryP MkLVV2FPT0WU
LU-99A Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTdwMUSzNlIh|ryP MnrlV2FPT0WU
NCI-H28 M2jpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTdwMkmyOEDPxE1? M2DqO3NCVkeHUh?=
MC-IXC NH\qUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;afZdtUUN3ME23MlQ5PTd4IN88US=> MkO0V2FPT0WU
GP5d MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\admRUUUN3ME23MlQ5PzZ2IN88US=> MYDTRW5ITVJ?
GB-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGzTYR4UUN3ME23MlU1QDB2IN88US=> NYX3UJlZW0GQR1XS
CAL-33 M2PjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjKWmxxUUN3ME23MlY3OjN|IN88US=> M1HjcXNCVkeHUh?=
MSTO-211H MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TQc2lEPTB;Nz62O|M{PiEQvF2= M1LCVnNCVkeHUh?=
TE-5 NXrPR3NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ETWM2OD15Lke5N|M1KM7:TR?= Ml21V2FPT0WU
D-566MG NEXH[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknFTWM2OD16LkC0OFI6KM7:TR?= M1yxS3NCVkeHUh?=
JVM-3 M1nk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRThwMUWyOlgh|ryP NYHFdYlLW0GQR1XS
T98G NWjiPI5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3GTWM2OD16LkG4NFY4KM7:TR?= Mlr2V2FPT0WU
HCC1954 M331V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRThwNEWxNFQh|ryP NG\2WINUSU6JRWK=
SF126 NXH0T3E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XMVmlEPTB;OD60OVk{PiEQvF2= NFrqOIlUSU6JRWK=
LB996-RCC NEe4NZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rMd2lEPTB;OD61N|I2PyEQvF2= MX3TRW5ITVJ?
SKG-IIIa MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzXTWM2OD16Lk[zNFY6KM7:TR?= NHezVVdUSU6JRWK=
NCI-SNU-1 NFm1dlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnjWlRKSzVyPUiuOlQ3PDNizszN MofpV2FPT0WU
LB771-HNC NFXQZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDU[ZBKSzVyPUiuOlQ3QTZizszN NEm1[ZpUSU6JRWK=
SCC-4 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XPO2lEPTB;OD62PFIyQSEQvF2= NWDVOGxoW0GQR1XS
CAMA-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIqxXJZKSzVyPUiuO|cyPDZizszN NGHyOGJUSU6JRWK=
D-502MG NHXTeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRThwN{i2Nlkh|ryP NH20SHFUSU6JRWK=
ESS-1 NGjUNVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P0RmlEPTB;OD64PFcxPCEQvF2= MXTTRW5ITVJ?
HEC-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrmTWM2OD16Lki5PFY3KM7:TR?= M{DWTXNCVkeHUh?=
NB10 NHPaVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHHTWM2OD17LkCyNlI1KM7:TR?= M3L5OHNCVkeHUh?=
8505C MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfKZopKSzVyPUmuNFQzOzJizszN MlLLV2FPT0WU
EFO-27 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTnepNSUUN3ME25MlE3PDF{IN88US=> NFLLZYhUSU6JRWK=
HN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\WfGNKSzVyPUmuNVY3OjhizszN NF3wbVdUSU6JRWK=
DSH1 NF\JeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHRTWM2OD17LkKwPFch|ryP M4S1cXNCVkeHUh?=
NBsusSR M{HLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH3TWM2OD17LkK3OFAzKM7:TR?= NXPOcVhCW0GQR1XS
LS-123 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTlwM{G3OlEh|ryP MVjTRW5ITVJ?
SHP-77 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTlwM{m5N|Uh|ryP NX;qeGZvW0GQR1XS
ACN MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\rVldKSzVyPUmuOVMzPzdizszN NGq4W3RUSU6JRWK=
U251 NVO3NXBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnhcldNUUN3ME25MlY2PTR2IN88US=> MU\TRW5ITVJ?
A431 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Lhc2lEPTB;OT64NFI{QCEQvF2= NYDKOIw4W0GQR1XS
5637 M1rU[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LMemlEPTB;OT64OFk5PCEQvF2= MojyV2FPT0WU
MDA-MB-157 NUjNR4g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LlXGlEPTB;OT65Nlg4QCEQvF2= M1:5TnNCVkeHUh?=
A101D NX7XUFBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[zS2lKSzVyPUmuPVk6PzRizszN NXPsSnZLW0GQR1XS
YKG-1 M4mzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjzTWM2OD1zMD6yNFA3KM7:TR?= Mm\DV2FPT0WU
LAN-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDpNYFTUUN3ME2xNE4zOTZ2IN88US=> MVvTRW5ITVJ?
OVCAR-5 NVG4SFJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljsTWM2OD1zMD6yOFM{KM7:TR?= M4rvRnNCVkeHUh?=
A549 NE\Ic2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFyLkO5O|Mh|ryP MXrTRW5ITVJ?
no-11 M4[4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFyLkSzOVMh|ryP M1G4e3NCVkeHUh?=
SF539 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHuT5ZKSzVyPUGwMlkxPDFizszN NGnJVFdUSU6JRWK=
A388 NFHrVlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH5TWM2OD1zMT6zPFk4KM7:TR?= MkjQV2FPT0WU
DEL NYjCTY9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjwdnNKSzVyPUGxMlQzPCEQvF2= NHThU49USU6JRWK=
SW954 M3LHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHUTWM2OD1zMT60OlY5KM7:TR?= MlrLV2FPT0WU
TK10 M3PBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCwTWM2OD1zMT61NlcyKM7:TR?= M3zudnNCVkeHUh?=
SW756 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LnbWlEPTB;MUGuOVI6PCEQvF2= MUTTRW5ITVJ?
PC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LpU2lEPTB;MUGuOVc3PCEQvF2= NI\uXlBUSU6JRWK=
ONS-76 NVPsfnozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXRTWM2OD1zMT62N|Yh|ryP M1;hOHNCVkeHUh?=
A427 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFzLkewPVMh|ryP MoThV2FPT0WU
MEG-01 NUDnfllRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfDVpRYUUN3ME2xNU44PTB7IN88US=> NVzRXXpLW0GQR1XS
BB30-HNC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3Hb2NKSzVyPUGxMlc6QDJizszN NYH2XGJHW0GQR1XS
NCI-H1299 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED5PFJKSzVyPUGxMlgxQTNizszN MULTRW5ITVJ?
GCT NUe5[VAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFzLkiyNlgh|ryP M{HURnNCVkeHUh?=
D-247MG NVTsbphjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnibZlrUUN3ME2xNU46PjZ|IN88US=> NIfE[XpUSU6JRWK=
CFPAC-1 NVH6TW41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn6TWM2OD1zMT65O|gzKM7:TR?= MoDLV2FPT0WU
EKVX M4Kzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfHTWM2OD1zMj6wN|E{KM7:TR?= MV7TRW5ITVJ?
CAL-51 NWPGUldkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTxTWM2OD1zMj6wO|E3KM7:TR?= NXryNnBTW0GQR1XS
BB49-HNC M2Ljemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XRRmlEPTB;MUKuNVE4PyEQvF2= NH\BcIRUSU6JRWK=
RPMI-7951 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LjbmlEPTB;MUKuNVg2PCEQvF2= NWW1S2x1W0GQR1XS
RH-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHieFRKSzVyPUGyMlIyQDRizszN NV[zZ3h1W0GQR1XS
BCPAP NFy4OIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXoSZljUUN3ME2xNk41PzR7IN88US=> MmLiV2FPT0WU
GCIY NGnC[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXHTWM2OD1zMj61NlA6KM7:TR?= NF:5[lFUSU6JRWK=
KNS-81-FD M1HLcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHrTWM2OD1zMj61PFY6KM7:TR?= MVzTRW5ITVJ?
KYSE-140 NGK1W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF{Lki1PVUh|ryP NEjqVndUSU6JRWK=
Ca-Ski MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0e2lEPTB;MUKuPVA1OSEQvF2= NYPDOYw4W0GQR1XS
TGBC1TKB MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP5TWM2OD1zMj65NVE2KM7:TR?= Mo\tV2FPT0WU
HCC1187 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2zRlBXUUN3ME2xN{4yQTF{IN88US=> MVPTRW5ITVJ?
SJSA-1 NVmxXFFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqwTWM2OD1zMz6yN|I4KM7:TR?= MXXTRW5ITVJ?
CTV-1 M3i0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3vbXBKSzVyPUGzMlM1PSEQvF2= M4TZZXNCVkeHUh?=
WM-115 M3f2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF|Lk[0PFMh|ryP NXzxdmQ6W0GQR1XS
CHP-212 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF|Lkm3N|kh|ryP NFrD[GVUSU6JRWK=
SCC-15 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF|Lkm3O|Uh|ryP M{Du[XNCVkeHUh?=
BPH-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGwUpNHUUN3ME2xOE4yPjZ2IN88US=> MYTTRW5ITVJ?
SW780 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\BN4psUUN3ME2xOE42ODJ3IN88US=> NWLj[oVOW0GQR1XS
NCI-H2291 M1Xtdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:5SYlYUUN3ME2xOE42QDd6IN88US=> MVrTRW5ITVJ?
JEG-3 NU[4U4piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLhVFVRUUN3ME2xOE43OzJ4IN88US=> NEnXXHdUSU6JRWK=
CAL-120 NWDaO5hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{noe2lEPTB;MUSuO|AzPyEQvF2= M2Xs[nNCVkeHUh?=
NCI-H23 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnh[lBxUUN3ME2xOE44QTl5IN88US=> M2fRNXNCVkeHUh?=
MS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfyTWM2OD1zND65OlEyKM7:TR?= NF\aNY1USU6JRWK=
PC-14 NIXEOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInY[W5KSzVyPUG0Mlk3PTRizszN NVrMbHBxW0GQR1XS
D-283MED MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr3[nE6UUN3ME2xOU4xOTFzIN88US=> MmXEV2FPT0WU
OE19 NVfXfFdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF3LkG1OFEh|ryP M3rMVHNCVkeHUh?=
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SH-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrJ[GNKSzVyPUK0Ok4xQSEQvF2= NEfvUFJUSU6JRWK=
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NCI-H2347 NWjoUJpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXjOJVKSzVyPUK0O{44OTNizszN NIG4UGFUSU6JRWK=
RPMI-8866 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nGdmlEPTB;MkS5MlI4KM7:TR?= NX7VbZN{W0GQR1XS
GAK MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH5R2d6UUN3ME2yOVMvODB{IN88US=> M1nkZnNCVkeHUh?=
NB6 NYP5TVFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\qTWM2OD1{N{CuNUDPxE1? NHLkR45USU6JRWK=
COLO-680N MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjBfG9EUUN3ME2yO|IvPTJ5IN88US=> NGDnO25USU6JRWK=
RERF-LC-MS NF[5NJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn1TWM2OD1{N{[uNFA4KM7:TR?= NIjGdopUSU6JRWK=
TGBC11TKB MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ5OD6xO|gh|ryP Mn7EV2FPT0WU
C8166 M{LZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnxTWM2OD1{N{iuOVA3KM7:TR?= M2DWWnNCVkeHUh?=
HDLM-2 M3;pUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Ww[2lEPTB;Mkm0MlQxQSEQvF2= NGLOVGJUSU6JRWK=
IGR-1 NHv1O4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\pOWlEPTB;Mkm1MlY2QSEQvF2= NIX5WphUSU6JRWK=
FADU MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi3TWM2OD1{OUeuOVEh|ryP MoHGV2FPT0WU
L-428 NHSyRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu5clVKSzVyPUK5O{43OTZizszN Mo\mV2FPT0WU
LU-65 MoHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;ZO45KSzVyPUOwOE4{OiEQvF2= MWrTRW5ITVJ?
HEL M4XFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\jTWM2OD1|MEmuPVg{KM7:TR?= NXryVIJVW0GQR1XS
NCI-H810 M{jBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTNzMD61O{DPxE1? M4\5VXNCVkeHUh?=
C3A MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2eGlEPTB;M{GxMlgxOiEQvF2= MlLvV2FPT0WU
NCI-H630 MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjRXIs3UUN3ME2zN|IvOjl2IN88US=> NFvNWYVUSU6JRWK=
KP-N-YN NVridZIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnnTWM2OD1|NEGuNVI{KM7:TR?= MlfMV2FPT0WU
MOLT-13 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfkdlFKSzVyPUO0Nk4{OjZizszN M3j2fHNCVkeHUh?=
NCI-H1993 NG\2[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN2Mj6zOlUh|ryP M1KzZnNCVkeHUh?=
BE-13 MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LhZ2lEPTB;M{S0MlE3PyEQvF2= NY\1SWhmW0GQR1XS
IST-SL1 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHKzVXRKSzVyPUO0O{41ODFizszN NHW2OmZUSU6JRWK=
TE-9 M3r6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN4Mz61PFkh|ryP M3LCc3NCVkeHUh?=
LU-135 NEPBbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPuTWM2OD1|NkeuNFM2KM7:TR?= M3f0[3NCVkeHUh?=
T84 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqwc5hUUUN3ME2zO|QvPzF{IN88US=> MWPTRW5ITVJ?
K-562 NGHp[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\mTWM2OD1|OEOuN|Yh|ryP MoPtV2FPT0WU
SBC-5 M3TlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzGcWQ4UUN3ME2zPFYvQTh3IN88US=> MULTRW5ITVJ?
NB17 M3m2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzuZYdKSzVyPUO5Nk42QTZizszN Ml36V2FPT0WU
NCI-H2052 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTuTWM2OD1|OUiuOFczKM7:TR?= MofRV2FPT0WU
HCC38 NXjicIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\k[oxFUUN3ME20NFEvPTl|IN88US=> MU\TRW5ITVJ?
NCI-H69 NU\j[|RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu3TWM2OD12NEGuNFg{KM7:TR?= NYe5bJVRW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]

Protocol

Kinase Assay:

[4]

+ Expand

Akt kinases assay:

Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.
Cell Research:

[2]

+ Expand
  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
  • Concentrations: 0, 0.3, 1 and 3 μM
  • Incubation Time: 72 or 96 hours
  • Method:

    MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
  • Formulation: Formulated in 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
17 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.39
Formula

C25H21N5O.2HCl

CAS No. 1032350-13-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01263145 Completed Adult Solid Neoplasm|Recurrent Breast Carcinoma|Stage IV Breast Cancer National Cancer Institute (NCI) January 5 2011 Phase 1
NCT01239342 Active not recruiting Metastatic Renal Cell Cancer|Recurrent Renal Cell Carcinoma|Stage IV Renal Cell Cancer National Cancer Institute (NCI)|M.D. Anderson Cancer Center January 27 2011 Phase 2
NCT01604772 Completed Recurrent Oral Cavity Adenoid Cystic Carcinoma|Recurrent Salivary Gland Carcinoma|Salivary Gland Adenoid Cystic Carcinoma|Stage IVA Major Salivary Gland Cancer AJCC v7|Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Stage IVB Major Salivary Gland Cancer AJCC v7|Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Stage IVC Major Salivary Gland Cancer AJCC v7|Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 National Cancer Institute (NCI) July 23 2012 Phase 2
NCT01480154 Active not recruiting Adult Solid Neoplasm|Hormone-Resistant Prostate Carcinoma|Recurrent Melanoma|Recurrent Prostate Carcinoma|Recurrent Renal Cell Carcinoma|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 National Cancer Institute (NCI) November 23 2011 Phase 1
NCT01251861 Active not recruiting Recurrent Prostate Carcinoma|Stage I Prostate Cancer AJCC v7|Stage IIA Prostate Cancer AJCC v7|Stage IIB Prostate Cancer AJCC v7|Stage III Prostate Cancer AJCC v7 National Cancer Institute (NCI) December 23 2010 Phase 2
NCT01021748 Completed Locally Advanced or Metastatic Solid Tumors Merck Sharp & Dohme Corp.|AstraZeneca November 23 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • Answer:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • Answer:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID