Fluorouracil (5-Fluorouracil, 5-FU)

Catalog No.S1209 Synonyms: NSC 19893

For research use only.

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 167 publications

Purity & Quality Control

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Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 M{HxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVK3NuKhcMLi M{jXbWlEPTB-IEK1JO69\y:vTB?= Mor3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
HL-60 NIHESIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TuS|czyqCqwrC= NVP6[YtkUUN3ME24MlYxOSEQvHevcWw> MoLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
HT-29 NVPLTVdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWOyToNOPzMEoHlCpC=> NWj1b5NEUUN3ME6gNlUh|rypL33M MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
MCF-7 NFT6R45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3MNWI4OsLiaNMg NH3KNppKSzVyPUKwJO69\y:vTB?= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
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HepG2 M{njcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIO4VpFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiSVO1NEA:KDF6Lkeg{txONg>? M3;H[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{CyN|M3Lz5zOEOwNlM{PjxxYU6=
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UACC257 NYO1XlJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF3XS4Y1QCCqcoO= Mni2S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gWWFESzJ3NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEOuOVQ5OTNizszNMi=> NWXkc4g2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
SNB19 MlX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2DUS|Q5KGi{cx?= NVnMSJB5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW06EMUmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCzMlgxOTh7IN88UU4> NFnPTGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
OVCAR4 MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXO0PEBpenN? NID1cZBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBQXkODUkSgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTC0MlQ3Pjh2IN88UU4> NFi2XmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
MDA-MB-231 M3vQTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHi5[ZM1QCCqcoO= NXvFXodGT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDZwNkC2PVMh|ryPLh?= NVj5VGI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
NCI-H522 NVeyXXpXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEfJNo01QCCqcoO= NWXCWoZET3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUA4NjJ2NEO2JO69VS5? M2L3WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
T47D NUeyb3FzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XHXFQ5KGi{cx?= NIXIRXBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOD6xNlg{OSEQvF2u NGHyT|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
CCRF-CEM NXXTU2t6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{ixWFQ5KGi{cx?= M3m3emdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gPU44PzJ|NzFOwG0v M2ruPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
Hs 578T M4H1T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHH6em41QCCqcoO= M1XqOWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGh{KDV5OGSgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTC5Mlc4OjN5IN88UU4> MnXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
BT549 Ml\FS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXu0PEBpenN? MnnpS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD63NVUzKM7:TT6= NXXpZpRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
OVCAR5 NGnwVYNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmiwOFghcHK| MWXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDPWmNCWjViY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD65OlQ5KM7:TT6= NWjyNm9yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
SKOV3 NVrqbWo2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVG0PEBpenN? NYXFfFFET3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCyNU45Pzd4IN88UU4> MlftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
HCT116 M2rSZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2DOelczKGi{cx?= NUDiUoFDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh\XiycnXzd4lv\yCyNUOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8h[XO|YYmsJGlEPTBiPTCxNkDPxE1w NUfJTVZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
A2780 MnfURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2PGTlczKGi{cx?= NV:5[m5ISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{BmgHC{ZYPzbY5oKHB3MzDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{Bie3OjeTygTWM2OCB;IEG0JO69VS5? NWPIZ3hTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
U2OS NIXDSJFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1LrcFczKGi{cx?= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV{T2OgZ4VtdHNiZYjwdoV{e2mwZzDwOVMh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9iYYPzZZktKEmFNUCgQUAyPiEQvF2u NHr0cpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
p53 deficient PC3 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF;1Zpg4OiCqcoO= MlLHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyNUOg[IVncWOrZX70JHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdyCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NFO4SHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
SF539 M1ryN2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYLYVGpwPzJiaILz NG\QdVVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPGOVM6KGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIF{e2G7LDDJR|UxKD1iNEOg{txONg>? NX\icYVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
HCT15 NGDYNoNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUC3NkBpenN? NGPkeGlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIF{e2G7LDDJR|UxKD1iNEig{txONg>? NU\6bnNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
T3M4 NV75OHJHS3m2b4TvfIlkcXS7IHHzd4F6 Mon1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFNOPCClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3MDC9JFAvOzNizszNMi=> NF\sfIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Colo-357 MlvmR5l1d3SxeHnjbZR6KGG|c3H5 NHLjfJpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEd2yxLUO1O{Bk\WyuczDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzygTWM2OCB;IEKuNFUh|ryPLh?= MkjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
Patu-T MWLDfZRwfG:6aXPpeJkh[XO|YYm= MkjJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOi5yODFOwG0v M3H2VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUOwNVI{Lz5{MEmzNFEzOzxxYU6=
Patu-S NVXydoxiS3m2b4TvfIlkcXS7IHHzd4F6 M{DsV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvUzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwOUOg{txONg>? NIHUe5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Aspc-1 MnqwR5l1d3SxeHnjbZR6KGG|c3H5 M3Oy[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{eGNvMTDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwOUeg{txONg>? NXvUXFdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
PANC1 Mof4R5l1d3SxeHnjbZR6KGG|c3H5 Mmr4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUCgQUA{Njl2IN88UU4> NXvacIhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
Patu-02 NV\HOVVlS3m2b4TvfIlkcXS7IHHzd4F6 M1fxdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvMEKgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB|Lkm1JO69VS5? NVXWPIdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
DAN-G NV\HdFVqS3m2b4TvfIlkcXS7IHHzd4F6 NVrUUVZGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEGQLVegZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB2LkO4JO69VS5? NGTYN4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-T MmXXR5l1d3SxeHnjbZR6KGG|c3H5 NXHzSFZjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPS2IVT3y[ZNqe3SjboSgVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOzNwMjFOwG0v MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Hep2 MontRY51cWOjbnPldkBie3OjeR?= NX\qfHBpPDhiaILz M3z6VmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZAzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCwMlMh|ryPLh?= NEKxSJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC3OFQ1PCd-MkGwO|Q1PDR:L3G+
A549 NIHzV4ZCdnSrY3HuZ4VzKGG|c3H5 Moi5OFghcHK| NV22bJl6SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFIvPCEQvF2u MojHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
HCT15 MYLBcpRq[2GwY3XyJIF{e2G7 MUi0PEBpenN? NHTGNFZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMvPiEQvF2u Mn7UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
502713 M1PkeWFvfGmlYX7j[ZIh[XO|YYm= MYW0PEBpenN? MnXERY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIEWwNlcyOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE43KM7:TT6= MnqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
DU145 MoT5RY51cWOjbnPldkBie3OjeR?= MV60PEBpenN? MYjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IESuPEDPxE1w MkPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
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HT-29 NH;5epNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYW3NkBpenN? M4fJO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKG2ndHjv[EwhUUN3MDC9JFcvOyEQvF2u M{jwcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{[1PFk4Lz5{Mke2OVg6PzxxYU6=
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HT1080 NED4SVFEgXSxdH;4bYNqfHliYYPzZZk> NHToN4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xPiEQvF2u NImwT5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
A375-S2 NYTM[FA5S3m2b4TvfIlkcXS7IHHzd4F6 NXXSVItUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTN5NT3TNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA6Njl{IN88UU4> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
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HepG2 MV;DfZRwfG:6aXPpeJkh[XO|YYm= M{nKTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlQ2KM7:TT6= NV3EWIl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
BGC823 NHP1OoxEgXSxdH;4bYNqfHliYYPzZZk> NH7Id|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDT0N6MkOgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPjVizszNMi=> M{LBfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
Hep2 Mlu3R5l1d3SxeHnjbZR6KGG|c3H5 M2fjemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOVgh|ryPLh?= NIXLTVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
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A549 NWO3V3k1S3m2b4TvfIlkcXS7IHHzd4F6 MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNzLkWyJO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
MDA231 MoDRR5l1d3SxeHnjbZR6KGG|c3H5 NUPre2oyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDMkOxJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMyNjV5IN88UU4> NXfafJdsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
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MGC803 M3X6[WN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml3WO|IhcHK| M{HYSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6wNUDPxE1w NVjIXHpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVM4PDNpPkKzN|U{PzR|PD;hQi=>
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leukemia NILGe2REgXSxdH;4bYNqfHliYYPzZZk> Mlm5OFghcHK| MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WucHjvdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCxOU4yKM7:TT6= NIrxS4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3OFg6QSd-MkO0O|Q5QTl:L3G+
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HCT116 M{XKOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUK0PEBpenN? MX;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSByLkKyJO69VS5? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6N{C1OUc,OjN6OEewOVU9N2F-
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MDA-MB-231 MUnDfZRwfG:6aXPpeJkh[XO|YYm= Ml3SOFghcHK| MkniR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUOuOlUh|ryPLh?= MlvqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MkCyOFYoRjJ|OUKwNlQ3RC:jPh?=
QGY7701 NU\qNoViS3m2b4TvfIlkcXS7IHHzd4F6 M3XmTFQ5KGi{cx?= MoTsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVWd[PzdyMTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwMzFOwG0v MnjNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MkCyOFYoRjJ|OUKwNlQ3RC:jPh?=
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A549 M{DpNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF62ZoQ4OiCqcoO= NWDZ[4F{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOy54IN88UU4> NVTq[2YzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlQ3PzdpPkKzPVY1Pjd5PD;hQi=>
SKOV3 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NGDkTog1QCCqcoO= NXH5bmZYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkSzJO69VS5? NWLPZnVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
HepG2 NWPIVnJFS3m2b4TvfIlkcXS7IHHzd4F6 MoDMOFghcHK| Mn3mR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI6Njl6IN88UU4> NXXyZnFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
A549 MmDlR5l1d3SxeHnjbZR6KGG|c3H5 M163S|Q5KGi{cx?= NYLzfZZUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzRwM{Og{txONg>? NWjOPI91RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
NCI-H460 NWHzTpA1S3m2b4TvfIlkcXS7IHHzd4F6 M3KxNlQ5KGi{cx?= M2X3SWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2ND6wOEDPxE1w M1nJcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUi4N|U4Lz5{M{m4PFM2PzxxYU6=
leukemia MmXtR5l1d3SxeHnjbZR6KGG|c3H5 MWO0PEBpenN? M173TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSBzLkWxJO69VS5? Ml:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUSzNlgoRjJ|OUm0N|I5RC:jPh?=
colon cancer M1HleGN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\wUlc5PDhiaILz M2fBWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gPE41KM7:TT6= Mk\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUSzNlgoRjJ|OUm0N|I5RC:jPh?=
prostate cancer MoPuR5l1d3SxeHnjbZR6KGG|c3H5 NWDBRpJVPDhiaILz NFPYeHlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDJ{Lkeg{txONg>? NXzP[ZpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVQ{OjhpPkKzPVk1OzJ6PD;hQi=>
renal cancer MoCyR5l1d3SxeHnjbZR6KGG|c3H5 M4\FbFQ5KGi{cx?= MnrCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTC0OU43KM7:TT6= NInhUlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5OFMzQCd-MkO5PVQ{Ojh:L3G+
A375-S2 M1zCe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml;QOFghcHK| NFfUS2tIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFGzO|UuWzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvPjdizszNMi=> NUXq[2ZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
HeLa NIq1cnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1XTN|Q5KGi{cx?= NFX5WFJIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuN|Qh|ryPLh?= NV76VoRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
HL60 M{\uSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVi0PEBpenN? MmPwS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD6wOUDPxE1w MlK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFYoRjJ|OUm5NFQ3RC:jPh?=
MCF7 NFnFWFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrXOFghcHK| MVTHdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLkWg{txONg>? M2fvT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm5NFQ3Lz5{M{m5PVA1PjxxYU6=
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HCT116 NHPlNGRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1[0N|Q5KGi{cx?= MXnHdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkeuO|Yh|ryPLh?= M{PCXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm5NFQ3Lz5{M{m5PVA1PjxxYU6=
HT1080 NIHhPXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYfBeFdTPDhiaILz Mn\2S5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKVEGwPFAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1MlYzKM7:TT6= NIm1N209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1Pid-MkO5PVkxPDZ:L3G+
HepG2 M2fjcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\KfVNRPDhiaILz NW\3W5N4T3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFAvOzRizszNMi=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0Okc,OjN7OUmwOFY9N2F-
A549 NX:0OVZCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWDpOpVLPDhiaILz NHPCc3BIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES0MlA2KM7:TT6= NWL6ZZZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
QSG7701 MVfDfZRwfG:6aXPpeJkh[XO|YYm= MlPPOFghcHK| NXjjR2JnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWVOJN{ewNUBk\WyuczDh[pRmeiB2ODDodpMh[nliQ1PLMVgh[XO|YYmsJGlEPTBiPTCwMlYh|ryPLh?= NYO1W45XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVM1OTVpPkK0NFE{PDF3PD;hQi=>
HepG2 MnzBR5l1d3SxeHnjbZR6KGG|c3H5 Mn\POFghcHK| MmrmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTJwNEig{txONg>? M2TDVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGzOFE2Lz5{NECxN|QyPTxxYU6=
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QGY7703 Mmq1R5l1d3SxeHnjbZR6KGG|c3H5 MlnzOFghcHK| M4jT[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFIYTd5MEOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMUWuOlYh|ryPLh?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzM{SxOUc,OjRyMUO0NVU9N2F-
Hep NHzFflZEgXSxdH;4bYNqfHliYYPzZZk> M{C0NVQ5KGi{cx?= M{TFfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= M4f3VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEW2NVQ3Lz5{NEC1OlE1PjxxYU6=
IMR32 M4K3VWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGfhNFY1QCCqcoO= MnTkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTW1TOzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFEvOyEQvF2u NUDCWIc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOVYyPDZpPkK0NFU3OTR4PD;hQi=>
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HCT116 NYrYcFlnS3m2b4TvfIlkcXS7IHHzd4F6 MVS0PEBpenN? NHvhW5REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwN{ig{txONg>? NF3wWZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFIyPyd-MkSzO|gzOTd:L3G+
HepG2 NXr6R|ZmS3m2b4TvfIlkcXS7IHHzd4F6 Mn\tOFghcHK| NWjKSpFFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ7Lkm4JO69VS5? NIHVXZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFIyPyd-MkSzO|gzOTd:L3G+
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CNE M2ixemN6fG:2b4jpZ4l1gSCjc4PhfS=> M1\UOVQ5KGi{cx?= NInyWZFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEVkViY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQxNjJzIN88UU4> NHHSdpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFIyPyd-MkSzO|gzOTd:L3G+
SPCA2 NHvqWmhEgXSxdH;4bYNqfHliYYPzZZk> MWC0PEBpenN? M37CWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNRS0F{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1Oi5{IN88UU4> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN5OEKxO{c,OjR|N{iyNVc9N2F-
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renal cancer NELVSWFEgXSxdH;4bYNqfHliYYPzZZk> NILUfVYyOCC3TR?= NV3jOGdOPDhiaILz Mn7sR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIF1KDFyIIXNJIFnfGW{IES4JIhzeyxiR1m1NEA:KDR3Lk[g{txONg>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR4OUGxNkc,OjR2NkmxNVI9N2F-
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HeLa NU\QSJI3S3m2b4TvfIlkcXS7IHHzd4F6 M4KyeVQ5KGi{cx?= NXy0dINnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOi5|IN88UU4> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV2N{e5OEc,OjR3NEe3PVQ9N2F-
HepG2 MVfDfZRwfG:6aXPpeJkh[XO|YYm= M3z6fFQ5KGi{cx?= NUHzfIxvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwNjFOwG0v NV;xNIpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OFc4QTRpPkK0OVQ4Pzl2PD;hQi=>
HCT116 MnrvR5l1d3SxeHnjbZR6KGG|c3H5 NFGwNHE1QCCqcoO= NFfnOnJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkSzJO69VS5? NID3bHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW2OVkxPSd-MkS1OlU6ODV:L3G+
SKOV3 MonwR5l1d3SxeHnjbZR6KGG|c3H5 MlzEOFghcHK| MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlQvPDNizszNMi=> M1zvNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
Bel7404 MofQR5l1d3SxeHnjbZR6KGG|c3H5 MonGOFghcHK| NUPS[XM3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSmWuN{SwOEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uPEDPxE1w NH7DSW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW2OVkxPSd-MkS1OlU6ODV:L3G+
HepG2 NVLzd3FpS3m2b4TvfIlkcXS7IHHzd4F6 MV:0PEBpenN? NELz[JFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwOUig{txONg>? MkTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NkW5NFUoRjJ2NU[1PVA2RC:jPh?=
NCI-H460 NXv3VXQyS3m2b4TvfIlkcXS7IHHzd4F6 Ml;3OFghcHK| NWnReYRJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2MlA1KM7:TT6= M1zEelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
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HT-29 Ml6xR5l1d3SxeHnjbZR6KGG|c3H5 MYe3NkBpenN? M3LoNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCDbHHtZZIhSmy3ZTDhd5NigSxiSVO1NEA:KDJ2Lki3JO69VS5? M3H0cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUizN|U2Lz5{NEW4N|M2PTxxYU6=
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DU145 NXXaRYl4S3m2b4TvfIlkcXS7IHHzd4F6 MVSyOEBpenN? M1TGVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkmg{txONg>? M17TelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkSxPVc2Lz5{NE[0NVk4PTxxYU6=
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LoVo NX\2TVNpSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M13rW|czKGi{cx?= MnzoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOb2\vJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gOE43QSEQvF2u MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
doxorubicin-resistant LoVo/DX NVrjOlFRSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4jqOFczKGi{cx?= NV;CZ2JJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhVG:Ybz;EXEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFYh|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
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vincristine-resistant HL60/Vinc MkLLRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVi3NkBpenN? NFXoU|NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwII\pcoNzcXO2aX7lMZJme2m|dHHueEBJVDZyL2\pcoMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIyNjF3IN88UU4> MmrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
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MGC803 NGH3bWFCdnSrY3HuZ4VzKGG|c3H5 M1PpdVczKGi{cx?= M3jmWGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkSzJO69VS5? M2XxR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW1O|E5Lz5{NU[1OVcyQDxxYU6=
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HepG2 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MUS0PEBpenN? M3TYbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OC55OTFOwG0v M1zjXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OESxNVk6Lz5{NUi0NVE6QTxxYU6=
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MDA-MB-231 MmjjR5l1d3SxeHnjbZR6KGG|c3H5 MmfwOFghcHK| MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3LkiyJO69VS5? NWDzZZBNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|AyOzFpPkK1PFcxOTNzPD;hQi=>
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KB MVPDfZRwfG:6aXPpeJkh[XO|YYm= M3HnTlczKGi{cx?= NWHY[Gt2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvQDRizszNMi=> MoTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
HeLa M{DSV2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHO4SYg4OiCqcoO= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC2MlI{KM7:TT6= NF7rSZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
MCF7 MlzXR5l1d3SxeHnjbZR6KGG|c3H5 NFX4SZQ4OiCqcoO= MkWwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHP2OnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC2MlU{KM7:TT6= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
HepG2 NX\xbm82S3m2b4TvfIlkcXS7IHHzd4F6 MlyzO|IhcHK| M2r2fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA3NjZizszNMi=> NVn6eJlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
HDF NIH1SIlEgXSxdH;4bYNqfHliYYPzZZk> MmLhO|IhcHK| MnruR5l1d3SxeHnjbZR6KGGpYXnud5QhUESIIHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA4NjB{IN88UU4> NYG0fJd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
143B NV\PPHB[S3m2b4TvfIlkcXS7IHHzd4F6 NHG3SHI4OiCqcoO= M3LMd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFE1O0JiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFE{NjBzIN88UU4> NHLnbGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
thymidine kinase deficient 143B NFT0XFVEgXSxdH;4bYNqfHliYYPzZZk> MlnYO|IhcHK| NYjZbVdkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhOTR|QjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOTZwM{Gg{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
U87MG MnLzR5l1d3SxeHnjbZR6KGG|c3H5 MV:3NkBpenN? Mlz1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4VUdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCcMjDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOThwMkWg{txONg>? NX2ybJpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPFE4PDJpPkK3NFgyPzR{PD;hQi=>
PC3 MorLRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1yzSVQ5KGi{cx?= NV7rNXFbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuO|Yh|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
HT-29 MkLrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIKyZ2k1QCCqcoO= NXq3bGZISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk45KM7:TT6= NXHTNXk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
U87MG NIHxSoNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWr1TXNwPDhiaILz NYnkSpJbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{43PSEQvF2u NWTROItFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
A549 M{fFTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEXCT4U1QCCqcoO= NYPWSIlZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlk5KM7:TT6= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
HaCaT MlOwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2nwTFQ5KGi{cx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEijQ3HUJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6xOUDPxE1w MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
MGC803 M37QdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4[4b|czKGi{cx?= MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkK1JO69VS5? M3nMTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
EC109 NILydYRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MknWO|IhcHK| MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFMUC5JINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwMUeg{txONg>? M2fsWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
SH-SY5Y Mkf2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NV62d25SPzJiaILz NY\oO4U1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvOjZizszNMi=> NEnKZmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
U87 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mnn2O|IhcHK| MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6NzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjZzIN88UU4> M2rVbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
MCF7 M1:zNmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MYm3NkBpenN? NX7CNFFtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuOlEh|ryPLh?= M{PmblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
MDA-MB-231 MojaRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NF;nRmE1QCCqcoO= M4PCVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwNjFOwG0v NHraWpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE5OCd-MkexNlgyQDB:L3G+
MCF7 NHn4flNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mo[3OFghcHK| M2nrW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{CuOFEh|ryPLh?= M3rPZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
A549 NVnTN4x4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX2wVldFPDhiaILz MoHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|NT60NUDPxE1w NXTpNpFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyQDBpPkK3NVI5OThyPD;hQi=>
HepG2 NG\FemFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3m2eFQ5KGi{cx?= NEfxOYhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Ok45OyEQvF2u Mlq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixPFAoRjJ5MUK4NVgxRC:jPh?=
MCF7 MUfDfZRwfG:6aXPpeJkh[XO|YYm= NEPydmk1QCCqcoO= M1XiT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjVizszNMi=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
Bcap37 NICyOWNEgXSxdH;4bYNqfHliYYPzZZk> M1\2O|Q5KGi{cx?= NX\Z[29{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSmOjcEO3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT60O{DPxE1w M{fONVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
Hep3B MkPYR5l1d3SxeHnjbZR6KGG|c3H5 NWG1V29ZPDhiaILz NHO1U|FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTdwNUOg{txONg>? M2i4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
A549 M{D4bWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnvOOFghcHK| NX;DVpZrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjFwNUig{txONg>? M2SxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
U251 NFrtNFBEgXSxdH;4bYNqfHliYYPzZZk> NXHoe3pOPDhiaILz MlvjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVI2OSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlQvPjlizszNMi=> NG[xeIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
HepG2 MUnDfZRwfG:6aXPpeJkh[XO|YYm= M1vCcVQ5KGi{cx?= NWLvNYhtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ3LkG3JO69VS5? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
LNCAP M1ewNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVWxdIxHOjRiaILz MnThR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhOjRiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTCwMlA{KM7:TT6= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF3Nke3NEc,OjdzNU[3O|A9N2F-
PC3 MknlR5l1d3SxeHnjbZR6KGG|c3H5 MV:yOEBpenN? M2HUW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkAzPCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IECuNFMh|ryPLh?= NF7wdJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G1Olc4OCd-MkexOVY4PzB:L3G+
Bcap37 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NIXie3g1QCCqcoO= MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwMUig{txONg>? MnHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEm2O|YoRjJ5MUi5Olc3RC:jPh?=
MCF7 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MorMOFghcHK| MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS53IN88UU4> NWL6[XJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFk3PzZpPkK3NVg6Pjd4PD;hQi=>
Hep3B MXrDfZRwfG:6aXPpeJkh[XO|YYm= NYLjNGh[PDhiaILz MonDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ{Lkm5JO69VS5? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6OU[3Okc,OjdzOEm2O|Y9N2F-
HepG2 M2HvfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYm0PEBpenN? M2LWd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2MD6zOEDPxE1w NXLt[XRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFk3PzZpPkK3NVg6Pjd4PD;hQi=>
A549 NF;LVGFEgXSxdH;4bYNqfHliYYPzZZk> NVzid4puPDhiaILz MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1PC5yNTFOwG0v MkL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEm2O|YoRjJ5MUi5Olc3RC:jPh?=
PA1 NWjkbWVzS3m2b4TvfIlkcXS7IHHzd4F6 M1HjXFQ5KGi{cx?= MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRVEh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvPTFizszNMi=> NVLFTnBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
U87MG M2jBTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGTxWmU1QCCqcoO= M2e2NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5P02JIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT60PEDPxE1w NGHTeZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KxNFQ{QCd-MkeyNVA1Ozh:L3G+
MCF7 MVnDfZRwfG:6aXPpeJkh[XO|YYm= NIqyUWk1QCCqcoO= NGXhToFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Mj6yO{DPxE1w NYLtXmtSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
LNCAP M1\BU2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVW0PEBpenN? MkfyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR5LkG4JO69VS5? NGi5SZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KxNFQ{QCd-MkeyNVA1Ozh:L3G+
MCF7 NHr5bHJEgXSxdH;4bYNqfHliYYPzZZk> MXOyOEBpenN? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygd5Vzfmm4YXLpcIl1gSCjZoTldkAzPCCqcoOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZoF{\WRibXnjdo9{[2:yaXOgZY5idHm|aYOsJGlEPTBiPTCxNU4yKM7:TT6= M2\sVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkO0PFk{Lz5{N{KzOFg6OzxxYU6=
HepG2 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVW0PEBpenN? MojiRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNE[uPFMh|ryPLh?= NYDNZmwzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFc{PjhpPkK3Nlg4OzZ6PD;hQi=>
A375-S2 MlL6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXXZPYdxPDhiaILz M{m4UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUO3OU1UOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgdoVlfWO2aX;uJIF{e2G7LDDJR|UxKD1iMT65NUDPxE1w NGH2eVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{K5OVUxPid-MkeyPVU2ODZ:L3G+
ACHN Mlv1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2fPTVQ5KGi{cx?= MlrvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDQ1jOJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUAzNjd|IN88UU4> M2[4WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mkm1OVA3Lz5{N{K5OVUxPjxxYU6=
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C4-2B MkSzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHjtRms1QCCqcoO= MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEN2LULCJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUA2NjZ2IN88UU4> NXW5eJlrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPVU2ODZpPkK3Nlk2PTB4PD;hQi=>
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A549 M1XQ[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NH2zRpg4OiCqcoO= MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDXV3QuQCCjc4PhfUwhUUN3MDC9JFIvQCEQvF2u NWjRSI5URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezNVE5QTVpPkK3N|EyQDl3PD;hQi=>
MDA-MB-231 NYDPdGt5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml3yO|IhcHK| NHH6endCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDXV3QuQCCjc4PhfUwhUUN3MDC9JFUvOiEQvF2u NET3XlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{OxNVg6PSd-MkezNVE5QTV:L3G+
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MCF7 M161WWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUK0PEBpenN? MkDRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNizszNMi=> NFjpZXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O0N|g2Oyd-MkezOFM5PTN:L3G+
WI38 M4HwSGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DHfFQ5KGi{cx?= NEG1Ro5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUTN6IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNDFOwG0v NWPi[25{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezOFM5PTNpPkK3N|Q{QDV|PD;hQi=>
HepG2 NXPGeGxRS3m2b4TvfIlkcXS7IHHzd4F6 MkLROFghcHK| MmXOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6IN88UU4> NVXvepBXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezOFM5PTNpPkK3N|Q{QDV|PD;hQi=>
UO31 MkC4R5l1d3SxeHnjbZR6KGG|c3H5 MVO0PEBpenN? NEDYVFJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWVzNzIHPlcIx{KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA3Njd4MEizJO69VS5? MnjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd|OUGxN|UoRjJ5M{mxNVM2RC:jPh?=
U251 NYK5c3hHS3m2b4TvfIlkcXS7IHHzd4F6 M{TEO|Q5KGi{cx?= NFi4VY5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzIHPlcIx{KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA1Oi54NUe5JO69VS5? NWPtdGRDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezPVEyOzVpPkK3N|kyOTN3PD;hQi=>
HCT116 MnfOR5l1d3SxeHnjbZR6KGG|c3H5 MYm0PEBpenN? NIjBVJJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTVwM{ig{txONg>? M{j5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4O|c1Lz5{N{S0PFc4PDxxYU6=
MDA-MB-231 MlfWR5l1d3SxeHnjbZR6KGG|c3H5 NUH6dYFRPDhiaILz MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN3LkmxJO69VS5? NELLXXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S0PFc4PCd-Mke0OFg4PzR:L3G+
A549 MWXDfZRwfG:6aXPpeJkh[XO|YYm= MYO0PEBpenN? MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO5Mlg3KM7:TT6= NW\iN|lRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg4PzRpPkK3OFQ5Pzd2PD;hQi=>
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MCF7 Mn;qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1TFR|czKGi{cx?= NYnLemhuT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwJF0hOy54IN88UU4> NXvUVFY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1NFQ2OzdpPkK3OVA1PTN5PD;hQi=>
PC3 M3TucGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDCO|IhcHK| MmHPS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGdKPTBiPTC0MlEh|ryPLh?= M4nId|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUC0OVM4Lz5{N{WwOFU{PzxxYU6=
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prostate cancer cell NEPWSmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3e4VFQ5KGi{cx?= M3qybmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJJBzd3O2YYTlJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOjJwNzFOwG0v MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV3NES0OEc,Ojd3NUS0OFQ9N2F-
renal cancer cell NFjGZ41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\TSFQ5KGi{cx?= Ml:0S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTC0OU43KM7:TT6= NGnSR249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W1OFQ1PCd-Mke1OVQ1PDR:L3G+
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DU145 NGD3eHNEgXSxdH;4bYNqfHliYYPzZZk> NHjZTnJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGK7IF3UWEBie3OjeTygTWM2OCB;IEGuOkDPxE1w MoXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVkoRjJ5NU[xO|E6RC:jPh?=
MDA-MB-231 Mn\hR5l1d3SxeHnjbZR6KGG|c3H5 M17LfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjhizszNMi=> Mmr2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVkoRjJ5NU[xO|E6RC:jPh?=
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GES-1 MYjDfZRwfG:6aXPpeJkh[XO|YYm= NV;NTIVKPzJiaILz MljIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2VUNTFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSBzMz63OUDPxE1w MmTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
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MDA-MB-231 MkXQR5l1d3SxeHnjbZR6KGG|c3H5 MV20PEBpenN? M3jGdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuPVgh|ryPLh?= NYPnR|VFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
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HepG2 Mof6R5l1d3SxeHnjbZR6KGG|c3H5 MkD4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkig{txONg>? Mm\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkCyPVYoRjJ5N{KwNlk3RC:jPh?=
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MGC803 NFXaU5JEgXSxdH;4bYNqfHliYYPzZZk> MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvOTRizszNMi=> NITlVFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVA{PCd-Mke3OlkxOzR:L3G+
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A549 NXG2dIlbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3PUdFczKGi{cx?= M1fJR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj64JO69VS5? NILOdpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
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Hep3B NG\CdY9EgXSxdH;4bYNqfHliYYPzZZk> NYfpUJo3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlM3KM7:TT6= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzM{G3PUc,Ojd7MUOxO|k9N2F-
A549 M4PoW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3HVUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj62N{DPxE1w NW\w[FNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NVMyPzlpPkK3PVE{OTd7PD;hQi=>
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HCT15 M2TOdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYmyOEBpenN? MnHvS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ2NjBzIN88UU4> NXrwbJJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNVEzOjBpPkK4NFEyOjJyPD;hQi=>
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HepG2 M{n4UmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUG0PEBpenN? NIDORW5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCClb3zvdolu\XS{aXOgZZN{[XluIFnDOVAhRSBzMD6xO{DPxE1w MlrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlcoRjJ6MEO4N|I4RC:jPh?=
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A549 NX7oVmx[S3m2b4TvfIlkcXS7IHHzd4F6 MWq0PEBpenN? M4nJUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[2:ub4LpcYV1emmlIHHzd4F6NCCLQ{WwJF0hOzRwMkeg{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
MCF7 NUO5U4ZrS3m2b4TvfIlkcXS7IHHzd4F6 MoLUOFghcHK| NFvkSYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDR{Lke4JO69VS5? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
Bcap37 MlHIR5l1d3SxeHnjbZR6KGG|c3H5 MWe0PEBpenN? MlrjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoNieDN5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDR5LkGg{txONg>? MlT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlcoRjJ6MEO4N|I4RC:jPh?=
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MGC803 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NX;yR2ZxPDhiaILz MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6yNUDPxE1w MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyPUc,OjhyM{izNlk9N2F-
EC109 M3i4V2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2jDblQ5KGi{cx?= M3GwNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVEOTB7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlMh|ryPLh?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyPUc,OjhyM{izNlk9N2F-
PC3 M{TLS2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3LsSVQ5KGi{cx?= NWe1RlRtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlMyKM7:TT6= MljxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlkoRjJ6MEO4N|I6RC:jPh?=
A549 NFmxfG9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1;zPFQ5KGi{cx?= MkG3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61JO69VS5? NUPKNVJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwO|M3PzZpPkK4NFc{Pjd4PD;hQi=>
MCF7 NIrFV|ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXXIR|k5PDhiaILz NUnneXVlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU4zKM7:TT6= M1zkfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEezOlc3Lz5{OEC3N|Y4PjxxYU6=
HCT116 M1\FOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1\IZlQ5KGi{cx?= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNkDPxE1w Mmf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyN{O2O|YoRjJ6MEezOlc3RC:jPh?=
BGC823 M1nVZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVu0PEBpenN? NE\DTWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLHR|gzOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|QvQCEQvF2u NHPLSlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC3N|Y4Pid-MkiwO|M3PzZ:L3G+
IOSE-144 NXH4SIxDSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnTsOFghcHK| MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEmRU1WtNVQ1KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPE4yKM7:TT6= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB5M{[3Okc,OjhyN{O2O|Y9N2F-
MCF7 M1G5ZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3r4UFQ5KGi{cx?= M2TyW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uNVQh|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzMEi3NUc,OjhzMUC4O|E9N2F-
HCT116 NHHIe2hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1\EbVQ5KGi{cx?= MkXaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO4MlMh|ryPLh?= M{jhdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUGwPFcyLz5{OEGxNFg4OTxxYU6=
PANC1 NUTjbZY3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHv0[Vk1QCCqcoO= MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCDTlOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Nz64N{DPxE1w NGXNNpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxNFg4OSd-MkixNVA5PzF:L3G+
HepG2 MoTQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUHnSGlIPDhiaILz NIX1emdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0PU4xOiEQvF2u MmrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUC4O|EoRjJ6MUGwPFcyRC:jPh?=
BCG823 NVjUVHF2S3m2b4TvfIlkcXS7IHHzd4F6 M3PjSlQ5KGi{cx?= M3TmWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJETzh{MzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlEh|ryPLh?= NIDmZo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxO|IxOid-MkixNVczODJ:L3G+
A549 MlXpR5l1d3SxeHnjbZR6KGG|c3H5 MXK0PEBpenN? MkXXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkGg{txONg>? MkHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUeyNFIoRjJ6MUG3NlAzRC:jPh?=
HepG2 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NYLuWpNQPDhiaILz MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5LkKg{txONg>? NVHoXXNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVczODJpPkK4NVE4OjB{PD;hQi=>
EC9706 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MknGOFghcHK| MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFOUewOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuNlYh|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzOUKwNEc,OjhzMUmyNFA9N2F-
ECA109 M1jSTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mne3OFghcHK| NYXoUIF1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR2EyODliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjJ3IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzOUKwNEc,OjhzMUmyNFA9N2F-
K562 MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEj5Tlc1QCCqcoO= MYHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDXV3QyKGG|c3H5MEBKSzVyIE2gN|gvPThizszNMi=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF{NkSzOkc,OjhzMk[0N|Y9N2F-
KKU-M214 MoGxR5l1d3SxeHnjbZR6KGG|c3H5 MWG3NkBpenN? NGrtZm1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMU1VvTUKxOEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMvPzZizszNMi=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF2MEW5Nkc,OjhzNEC1PVI9N2F-
HL60 NVnvfmZiSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHXCcHY1QCCqcoO= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDFwNkKg{txONg>? M33XXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUWyOFMxLz5{OEG1NlQ{ODxxYU6=
NCI-H1299 M2HiWmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3vIS|Q5KGi{cx?= NFTwToJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTJ7OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hQC57MTFOwG0v M1XoZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUWyOFMxLz5{OEG1NlQ{ODxxYU6=
MCF7 NFrZfHFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX63NkBpenN? NXHucnNmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlc2KM7:TT6= M3mwS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
Bel7402 NHG5U3BCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXG3NkBpenN? MnrlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlI2KM7:TT6= NYDEN2IzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
MGC803 MoTJRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmLKO|IhcHK| NGjmSI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4yOiEQvF2u NHnWTpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
K562 MkT0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXTTfYxYPzJiaILz MoDyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkW0JO69VS5? MlLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
HepG2 NXXST3ozS3m2b4TvfIlkcXS7IHHzd4F6 MYK0PEBpenN? MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwNUOg{txONg>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF5NEGwO{c,OjhzN{SxNFc9N2F-
Hep3B NGXlOIVEgXSxdH;4bYNqfHliYYPzZZk> NHz0TG41QCCqcoO= MnvLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR7LkeyJO69VS5? NILFRYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG3OFExPyd-MkixO|QyODd:L3G+
MCF7 NXO3fIdpS3m2b4TvfIlkcXS7IHHzd4F6 MVy3NkBpenN? MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAyNjRizszNMi=> NV\hU2VqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNVkxPDZpPkK4NlE6ODR4PD;hQi=>
HCT116 NXP1OYhUS3m2b4TvfIlkcXS7IHHzd4F6 NUXoNIpkPzJiaILz NX6xcoc3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxPE41KM7:TT6= M3LIelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG5NFQ3Lz5{OEKxPVA1PjxxYU6=
HuH7 NEjYVodEgXSxdH;4bYNqfHliYYPzZZk> NUXVTJg6PzJiaILz NWnFTmxsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMkGg{txONg>? NEHjWJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxPVA1Pid-MkiyNVkxPDZ:L3G+
A549 MkHDR5l1d3SxeHnjbZR6KGG|c3H5 NWPFUHRxOjRiaILz NUHkUIFlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5{IN88UU4> NHLX[Ys9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HeLa MmjLR5l1d3SxeHnjbZR6KGG|c3H5 MWOyOEBpenN? MonNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= NGPhc|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HepG2 M1LIc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVHUWIs3OjRiaILz MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= NWf0UWdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOVQ3QTdpPkK4NlU1Pjl5PD;hQi=>
COLO205 NHHVfVZEgXSxdH;4bYNqfHliYYPzZZk> NYjFeVdmOjRiaILz M1nZe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNQVE9{MEWgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwOTFOwG0v NYnsSmd3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOVQ3QTdpPkK4NlU1Pjl5PD;hQi=>
HepG2 NGPPRmJEgXSxdH;4bYNqfHliYYPzZZk> NXvlbJNHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk4yKM7:TT6= NIO3fG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK2NlUzPyd-MkiyOlI2Ojd:L3G+
Hep3B MV3DfZRwfG:6aXPpeJkh[XO|YYm= NG\HSnpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlY3KM7:TT6= M3LZO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mk[yOVI4Lz5{OEK2NlUzPzxxYU6=
Bel7402 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmfVO|IhcHK| MkHsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFUvQTRizszNMi=> MojVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MEG4NVUoRjJ6M{CxPFE2RC:jPh?=
LO2 M4\HOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWLFbFQ5PzJiaILz M1jJZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTF:yJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEOyMlU1PiEQvF2u NFPRWmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOwNVgyPSd-MkizNFE5OTV:L3G+
HCT116 NVLvWWhNS3m2b4TvfIlkcXS7IHHzd4F6 NHrmcIFEgXSxdH;4bYNqfHliaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NUDPxE1w M4nKSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O0OlU1Lz5{OEOzOFY2PDxxYU6=
MCF7 Mo\wR5l1d3SxeHnjbZR6KGG|c3H5 NWrURmQ6S3m2b4TvfIlkcXS7IHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OCB;IESxMlUh|ryPLh?= M2PJO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O0OlU1Lz5{OEOzOFY2PDxxYU6=
HeLa M2f0fWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2q5fVQ5KGi{cx?= NEHoe4tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuNFIh|ryPLh?= M4\Vb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{[zOFQ1Lz5{OEO2N|Q1PDxxYU6=
HepG2 NFzDRnVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWi0PEBpenN? MlnPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUOuN|Eh|ryPLh?= MnjBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NkO0OFQoRjJ6M{[zOFQ1RC:jPh?=
BGC823 Mn7LRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUO0PEBpenN? M1f0bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlfDPFI{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxO{4{PyEQvF2u NG[5d2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
SW1116 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVLNNJhEPDhiaILz M2rERWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2exNVE3KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPE42OiEQvF2u NHy4c2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
Hep3B NECwSXVEgXSxdH;4bYNqfHliYYPzZZk> NUTZdVZmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVEvQSEQvF2u MkXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|N{G2O|YoRjJ6M{exOlc3RC:jPh?=
MCF7 NFvi[pJEgXSxdH;4bYNqfHliYYPzZZk> MmrtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MDFOwG0v Mm\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|N{G2O|YoRjJ6M{exOlc3RC:jPh?=
HepG2 MlP3R5l1d3SxeHnjbZR6KGG|c3H5 MkHLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{KuOkDPxE1w NVzxNYpiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizO|E3PzZpPkK4N|cyPjd4PD;hQi=>
A549 NYTDTIVUS3m2b4TvfIlkcXS7IHHzd4F6 NH\jS4hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO4MlIh|ryPLh?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN5MU[3Okc,Ojh|N{G2O|Y9N2F-
MCF7 NFHZRZpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmnqOFghfG9iN{KgbJJ{ MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiaX7jeYJifGWmIH\vdkA1QCC2bzC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{43PyEQvF2u MkKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OUWyNVgoRjJ6M{m1NlE5RC:jPh?=
A549 NELId3lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MorDOFghfG9iN{KgbJJ{ NFnZXGJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwNkWg{txONg>? M1XQRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{m1NlE5Lz5{OEO5OVIyQDxxYU6=
SGC7901 M4XWU2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn\DOFghfG9iN{KgbJJ{ MnHERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVR1O3PVAyKGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF|LkK1JO69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN7NUKxPEc,Ojh|OUWyNVg9N2F-
HepG2 M3G1emFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4rIXlQ5KHSxIEeyJIhzew>? Moe1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDpcoN2[mG2ZXSg[o9zKDR6IITvJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy52NDFOwG0v M1LlVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{m1NlE5Lz5{OEO5OVIyQDxxYU6=
PC3 NWnlfVA5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYr3XHBQPDhidH:gO|IhcHK| NEL5fnhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDpcoN2[mG2ZXSg[o9zKDR6IITvJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{QC54MTFOwG0v NX7ZdYZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPVUzOThpPkK4N|k2OjF6PD;hQi=>
MCF7 M4HXcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXBe4o1QCCqcoO= MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCxMlY4KM7:TT6= NFzIZ409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{PSd-Mki0NFAzOzV:L3G+
A549 M3PYNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHW3W2Y1QCCqcoO= NWnvcVJ1T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOi5yOTFOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzOUc,Ojh2MECyN|U9N2F-
DU145 NH[1cHFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXOOFghcHK| MoLaS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFUvQDJizszNMi=> NInmbW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{PSd-Mki0NFAzOzV:L3G+
T47D MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2XBb|Q5KGi{cx?= NGLWRotCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS0O2Qh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGyMlEh|ryPLh?= M3HJTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NECwNlM5Lz5{OESwNFI{QDxxYU6=
A549 NWTjZ2E5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXG0PEBpenN? NFz0eXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlEh|ryPLh?= NH7YS3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{QCd-Mki0NFAzOzh:L3G+
HepG2 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWW0PEBpenN? M4fycGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlEh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzPEc,Ojh2MECyN|g9N2F-
HCT116 NIfCcnlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHzocYs1QCCqcoO= NEHHd2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlYvOiEQvF2u MlrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MECyN|goRjJ6NECwNlM5RC:jPh?=
MCF7 MoXJR5l1d3SxeHnjbZR6KGG|c3H5 M2XKWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMtKEmFNUCgQUA4NjlizszNMi=> NIXISno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNVM1OSd-Mki0N|E{PDF:L3G+
HepG2 Mnn3R5l1d3SxeHnjbZR6KGG|c3H5 NGDHWFNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiSVO1NEA:KDhwMTFOwG0v MkmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2M{GzOFEoRjJ6NEOxN|QyRC:jPh?=
HCT116 NIOxZmdEgXSxdH;4bYNqfHliYYPzZZk> MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUCgQUA6NjlizszNMi=> NGTlWVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNVM1OSd-Mki0N|E{PDF:L3G+
PC3 MULDfZRwfG:6aXPpeJkh[XO|YYm= M2LNZVQ5KGi{cx?= M1S0N2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4zKM7:TT6= NWrNWYJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
A549 M4XRWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MV[0PEBpenN? NIq1WGNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjZizszNMi=> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUi4NUc,Ojh2M{G4PFE9N2F-
HeLa MofVR5l1d3SxeHnjbZR6KGG|c3H5 NUTHZ2tsPDhiaILz NWCxUIlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS56NjFOwG0v NYjLOGJ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
DU145 Mnv1R5l1d3SxeHnjbZR6KGG|c3H5 M173b|Q5KGi{cx?= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk4yQCEQvF2u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUi4NUc,Ojh2M{G4PFE9N2F-
MDA-MB-231 MmfFR5l1d3SxeHnjbZR6KGG|c3H5 M3H4bFQ5KGi{cx?= M3rVRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuN|Mh|ryPLh?= M37CdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOxPFgyLz5{OESzNVg5OTxxYU6=
HGC27 MVLDfZRwfG:6aXPpeJkh[XO|YYm= MnW1OFghcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIS2MzPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvPzJizszNMi=> NUXGUohnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
MGC803 NEL1e3lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{K2WlczKGi{cx?= MmK2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPR1O4NFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IE[uOVYh|ryPLh?= NGPLT3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1OlA{OSd-Mki0OVYxOzF:L3G+
HGC27 MlztRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NULM[lhJPzJiaILz NFn4c|FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4MlIzKM7:TT6= MlvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NU[wN|EoRjJ6NEW2NFMyRC:jPh?=
NCI-H1650 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnziO|IhcHK| NXLRfmdzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF4NUCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{LkWyJO69VS5? MlS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NU[wN|EoRjJ6NEW2NFMyRC:jPh?=
HCT116 MlTNRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWe3NkBpenN? Mo\QRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuNVYh|ryPLh?= NGLWe5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1PFE{Oyd-Mki0OVgyOzN:L3G+
PC3 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1f3S|czKGi{cx?= MmDQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkOzJO69VS5? MkHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUixN|MoRjJ6NEW4NVM{RC:jPh?=
MCF7 NUjNPHp7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHLyXYE4OiCqcoO= M{f5NWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuO|Mh|ryPLh?= MoPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUixN|MoRjJ6NEW4NVM{RC:jPh?=
HepG2 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3zrc|czKGi{cx?= MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{OT6wO{DPxE1w M{\HelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEW4NVM{Lz5{OES1PFE{OzxxYU6=
Caco2 MmTkR5l1d3SxeHnjbZR6KGG|c3H5 M4nkTlI1KGi{cx?= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYNwOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|Eh|ryPLh?= MnviQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NkO3PFUoRjJ6NE[zO|g2RC:jPh?=
HeLa NUjoW2FPS3m2b4TvfIlkcXS7IHHzd4F6 NYXwdVhYPzJiaILz MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhX1OWODDhd5NigSxiSVO1NEA:KDF|Lkmg{txONg>? M4nWSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEi4PFYzLz5{OES4PFg3OjxxYU6=
HT-29 M3z2dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnTuO|IhcHK| MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Lkmg{txONg>? NETqZ2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2OSd-Mki0PVQzPTF:L3G+
PC3 NU[3V2NiSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEXDZVA4OiCqcoO= M4n5VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{ND6zJO69VS5? NILOSVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2OSd-Mki0PVQzPTF:L3G+
HepG2 MnXrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWPLO2dsPzJiaILz NG\5fWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyPU4yKM7:TT6= NEiydmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2OSd-Mki0PVQzPTF:L3G+
SW620 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVu3NkBpenN? NV3JdJl7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xQCEQvF2u NXz1cnNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5PDVpPkK4OVI2QDR3PD;hQi=>
CFPAC-1 NVvCfodjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnPDO|IhcHK| MkDRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFRmDBR{0yKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE1KM7:TT6= NHH1VIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEWyOVg1PSd-Mki1NlU5PDV:L3G+
WI38 NV22bItVS3m2b4TvfIlkcXS7IHHzd4F6 Mn\QO|IhcHK| MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXTVM5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlk1KM7:TT6= MnPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3MkW4OFUoRjJ6NUK1PFQ2RC:jPh?=
HeLa NYLWdIppSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoDQO|IhcHK| NXrTZldnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4MlgyKM7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV{NUi0OUc,Ojh3MkW4OFU9N2F-
HepG2 NY\6OJo5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV23NkBpenN? NGTzXnJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4Mlkh|ryPLh?= NYG2O5h4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5PDVpPkK4OVI2QDR3PD;hQi=>
HCT116 MkXsR5l1d3SxeHnjbZR6KGG|c3H5 MWm0PEBpenN? MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2MT65JO69VS5? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV|Mk[2PUc,Ojh3M{K2Olk9N2F-
A549 MmjTR5l1d3SxeHnjbZR6KGG|c3H5 M1zBZ|czKGi{cx?= NVO3ZVd7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IESuO{DPxE1w M36zNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUW4PVcxLz5{OEW1PFk4ODxxYU6=
HeLa MnH1R5l1d3SxeHnjbZR6KGG|c3H5 NHvsUmc4OiCqcoO= MmnlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhX1OWODDhd5NigSxiSVO1NEA:KDVwMzFOwG0v NH[wTW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW1PFk4OCd-Mki1OVg6PzB:L3G+
MCF7 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NWCwOmdKPzJiaILz MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBYW1R6IHHzd4F6NCCLQ{WwJF0hPS54IN88UU4> Mni3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NUi5O|AoRjJ6NUW4PVcxRC:jPh?=
WI38 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M{jSNlczKGi{cx?= M2\5SGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdKOzhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KFeVVEigZZN{[XluIFnDOVAhRSB4Lkig{txONg>? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV3OEm3NEc,Ojh3NUi5O|A9N2F-
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K562 NWDGc|dNS3m2b4TvfIlkcXS7IHHzd4F6 Mk\TOFghcHK| NEPjNIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT60PUDPxE1w M1L1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOzNFQ6Lz5{OUGzN|A1QTxxYU6=
WM9 MmriR5l1d3SxeHnjbZR6KGG|c3H5 Mlf2OFghcHK| NHj1d3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYVTliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT64JO69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|M{C0PUc,OjlzM{OwOFk9N2F-
HEL MVvDfZRwfG:6aXPpeJkh[XO|YYm= Ml7kOFghcHK| NVSzT5ZPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuPVgh|ryPLh?= NFvUcIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzN|A1QSd-MkmxN|MxPDl:L3G+
MDA-MB-231 MkHWR5l1d3SxeHnjbZR6KGG|c3H5 MYG0PEBpenN? NEnSd2pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTdwN{Sg{txONg>? Ml7FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzM{OwOFkoRjJ7MUOzNFQ6RC:jPh?=
PC3 Mly0R5l1d3SxeHnjbZR6KGG|c3H5 MYe0PEBpenN? NHHYRYJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOT64O{DPxE1w MkHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzM{OwOFkoRjJ7MUOzNFQ6RC:jPh?=
PC3 M1fJPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYr2W45UPDhiaILz MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC55NTFOwG0v NXzRfIlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxPTFpPkK5NVM{ODVzPD;hQi=>
A549 NXOxS5pFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWPj[2I1PDhiaILz M3[4WWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD60PEDPxE1w NW\HUIFMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxPTFpPkK5NVM{ODVzPD;hQi=>
SGC7901 M{PDXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGflTYg1QCCqcoO= Mm\WRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVR1O3PVAyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE46QCEQvF2u NHTMXIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzN|A2OSd-MkmxN|MxPTF:L3G+
MGC803 NUjFdZFmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3rqTVQ5KGi{cx?= NIjNS2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvOTVizszNMi=> M{nE[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOzNFUyLz5{OUGzN|A2OTxxYU6=
HT-29 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NEH0fJE1QCCqcoO= NXvHO2plS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC5|IN88UU4> NXezdYFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxPjFpPkK5NVM{ODZzPD;hQi=>
HCT15 MnzPR5l1d3SxeHnjbZR6KGG|c3H5 MnHhOFghcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{42OyEQvF2u MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF5NEixN{c,OjlzN{S4NVM9N2F-
Bel7402 MoLqR5l1d3SxeHnjbZR6KGG|c3H5 NUnYO5llPDhiaILz NF;5[HNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD\Wx5NECyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MD65N{DPxE1w NHTzcZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG3OFgyOyd-MkmxO|Q5OTN:L3G+
MCF7 M{XCU2N6fG:2b4jpZ4l1gSCjc4PhfS=> MojyOFghcHK| NILp[XZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzQC57NzFOwG0v MmPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzN{S4NVMoRjJ7MUe0PFE{RC:jPh?=
U937 M3LXdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1;uflQ5KGi{cx?= NE[5TFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgbY4heHKnc3XuZ4Uhd2ZidXLlcolu\XhiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwNU[g{txONg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJyMkO5PEc,Ojl{MEKzPVg9N2F-
HepG2 MXXBc