Fluorouracil (5-Fluorouracil, 5-FU)

Catalog No.S1209 Synonyms: NSC 19893

For research use only.

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 159 publications

Purity & Quality Control

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Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NIW1eIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\NZphxPzMEoHlCpC=> M{jVN2lEPTB-IEK1JO69\y:vTB?= NVXrc3VxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HL-60 NIHlb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfo[ok4OsLiaNMg NHjGcYNKSzVyPUiuOlAyKM7:Zz;tUC=> NIHSTlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
HT-29 M2jEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK4O|LDqGkEoB?= MXLJR|UxRiB{NTFOwIcwdUx? M2PPV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
MCF-7 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV23NuKhcMLi MW\JR|UxRTJyIN88[{9uVA>? M3XP[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
L1210/0 M33MR2Z2dmO2aX;uJIF{e2G7 MljzSYZn\WO2IH;uJGwyOjFyL{CgZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IECuN{DPxE1w MnLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MkK3PEc,OjN4MkK3PFww[T5?
CCRF-CEM NHflNWpHfW6ldHnvckBie3OjeR?= MkS2SYZn\WO2IH;uJGNEWkZvQ1XNJINmdGy|IHnuJIN2dHS3cnWsJGlEPTBiPTCyJO69VS5? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ{Mke4K|4zOzZ{Mke4QE9iRg>?
P388 NUHVZmdYSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnTnOFghcHK| NGfLW|ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGCzPFgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlA6KM7:TT6= M{H3ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{i0OFkoRjJ5N{i0OFk9N2F-
HT-29 NVu4WIRHSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{\ncVk3KGi{cx?= M{fLR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlkh|ryPLh?= NYfzWVI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3PFQ1QSd-Mke3PFQ1QTxxYU6=
L1210 M37wcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIH;mJGwyOjFyIH3veZNmKEyndXvlcYliKGOnbHzzMEBKSzVyIE2gNE4{KM7:TT6= MofrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{O3OUc,Ojl4N{O3OVww[T5?
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L1210 NH7VNmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnTWmZkPDhiaILz NWjJcHhSUW5idnn0do8h\3Kxd4ToJIlvcGmkaYTpc44hd2ZiTEGyNVAh[2WubIOgOFghcG:3coOgZYZ1\XJiYXTtbY5qe3S{YYTpc44hd2ZiY3;tdI92dmRuIFnDOVAhRSByLkGyJO69VS5? NELMenk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NkK5PFA3Lz55NkK5PFA3RC:jPh?=
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CHO NIDOPItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk[2S5Jwf3SqIHnubIljcXSxcomgZYN1cX[rdImgZYdicW6|dDDDTG8h[2WubIOgbY4h[3WudIXy[U4tKEmFNUCgQUA2KM7:TT6= NV\OXpNWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{i1N|M1Oid-N{i1N|M1OjxxYU6=
SCLC NX;1dXVzS3m2b4TvfIlkcXS7IHHzd4F6 MmHJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2NNSyClZXzsd{Bz\XOrc4ThcpQhfG9iY3nzdIxifGmwIDjTR2xEN0OGRGCpMEBKSzVyIE2gPE41KM7:TT6= M2T2SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh{NUi4N|UoRjh{NUi4N|U9N2F-
T-24 MoD4R5l1d3SxeHnjbZR6KGG|c3H5 MoTIWIV{fGWmIH\vdkBkgXSxdH;4bYNqfHliYXfhbY5{fCCjboTp[4VvKG6nZ3H0bZZmKFRvMkSgZoxi\GSncjDjZZJkcW6xbXGgZ4VtdHNiaHH2bY5oKG:wbImgN{02LSCjboTp[4VvKGW6cILld5Nqd25uIFnDOVAhRSB2LkGg{txONg>? NVfDV4dvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOES5OlkzPid-OES5OlkzPjxxYU6=
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PBM NYLj[ldbS3m2b4TvfIlkcXS7IHHzd4F6 NXzNSZhIXGW|dHXkJIlvKH[rdILvJIZweiCleYTveI95cWOrdImgZYdicW6|dDDQRm0h[2WubIOsJGlEPTBiPTC1JO69VS5? NUPPVI9nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCwO|I3QDNpPkGwNFczPjh|PD;hQi=>
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SK-MES-1 MkHTRY51cWOjbnPldkBie3OjeR?= NWDh[VI6XGW|dHXkJIlvKH[rdILvJIZweiCjboTpZ4Fv[2W{IHHjeIl3cXS7IHHnZYlve3RiU1utUWVUNTFiY3XscJMtKEmFNUCgQUAyOy5zIN88UU4> NVHLOXh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCwO|I3QDNpPkGwNFczPjh|PD;hQi=>
HepG2 MYHBcpRq[2GwY3XyJIF{e2G7 MoTMWIV{fGWmIHnuJJZqfHKxIH\vdkBidnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhUGWyR{KgZ4VtdHNuIFnDOVAhRSB|Nz65JO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODB5Mk[4N{c,OTByN{K2PFM9N2F-
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MDA-MB-435S M3zicGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFKwXJc4OiCqcoO= NECwfXNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iMUSuOUDPxE1w M1HUclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUK0OlU2Lz5zN{WyOFY2PTxxYU6=
HCCLM7 Ml72RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUHPcZRtPzJiaILz M{SxV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPDUG04KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gNVgvPiEQvF2u MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV{NE[1OUc,OTd3MkS2OVU9N2F-
Caco-2 MmnFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NULLUZlQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS2Glbz2yJINmdGy|LDDJR|UxKD1iMT61JO69VS5? Ml7EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixNlkoRjF5NUS4NVI6RC:jPh?=
MCF7 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{Sx[FczKGi{cx?= MmXMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{whUUN3MDC9JFAvOyEQvF2u MmrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixPVgoRjF5NUS4NVk5RC:jPh?=
HCT116 NXTvPIpnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWq3NkBpenN? NXH2dIVvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxKD1iMj64JO69VS5? MlPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixPVgoRjF5NUS4NVk5RC:jPh?=
SW480 M4XWPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MonaO|IhcHK| M{HlXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e0PFAh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hOy53IN88UU4> M1rzOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUS4NVk5Lz5zN{W0PFE6QDxxYU6=
SW48 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{TUUFczKGi{cx?= NIP4SGRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hPS5|IN88UU4> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
DLD1 M1TOOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PhXGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRNTDFiY3XscJMtKEmFNUCgQUA1NjVizszNMi=> Mk\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUO2PFUoRjF5NUWzOlg2RC:jPh?=
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colon cancer cell NF\WWIhEgXSxdH;4bYNqfHliYYPzZZk> MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOsJGdKPTBiPTC1Mlc2KM7:TT6= NHz0NW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2NlM3PSd-MUe1OlI{PjV:L3G+
A549 NVrTSI9tS3m2b4TvfIlkcXS7IHHzd4F6 NGDuSHQ1QCCqcoO= NIG4OnZEgXSxdH;4bYNqfHliYXfhbY5{fCCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? M1LTSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkC0N|k1Lz5zN{[wOFM6PDxxYU6=
L1210 M1;3eWN6fG:|dHH0bYMh[WO2aY\peJkh[XO|YYm= NUi0UotDS3m2b4P0ZZRq[yCjY4Tpeol1gSCjZ3HpcpN1KG2xdYPlJGwyOjFyIHPlcIx{NCCLQ{WwJF0hOC5{ODFOwG0v MmC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7M{G4OlIoRjF5OUOxPFYzRC:jPh?=
CEM NUDSV2UzS3m2b4P0ZZRq[yCjY4Tpeol1gSCjc4PhfS=> NH;F[VNEgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzMEBKSzVyIE2gPUDPxE1w MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl|MUi2Nkc,OTd7M{G4OlI9N2F-
Molt4/C8 MUjDfZRwe3SjdHnjJIFkfGm4aYT5JIF{e2G7 MXrDfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTX;seFQwSzhiY3XscJMtKEmFNUCgQUAzOyEQvF2u M3HGXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUOxPFYzLz5zN{mzNVg3OjxxYU6=
Caco-2 NFzxRmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUSxNEBl[Xm| NWXjNGc1T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS2Glbz2yJINmdGy|IHHmeIVzKDFyIHThfZMtKEmFNUCgQUAyNjVizszNMi=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB|N{G5OUc,OThyM{exPVU9N2F-
MCF7 NUDMVVhuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVLXcGlqOyCmYYnz MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDRwM{Kg{txONg>? NUL6boFZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwOlkxQTNpPkG4NFY6ODl|PD;hQi=>
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embryonic cell Mn;USpVv[3Srb36gZZN{[Xl? M1LBemlv\HWldHnvckBw\iClbHXheoFo\SCjcoLld5QhcW5iZX3idplwdmmlIHPlcIx{KG:oIIP0ZYdmKDhiWHXuc5B2eyCuYXX2bZMh[myjc4T1cIFmNCCLQ{WwJF0hOjZwODFOwG0v NV3S[mxORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyO|E2PThpPkG4NlcyPTV6PD;hQi=>
HepG2 NEnMZVBEgXSxdH;4bYNqfHliYYPzZZk> NWHyUGl2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSBzOD63JO69VS5? M2rXWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{CyN|M3Lz5zOEOwNlM{PjxxYU6=
L1210 NU\CbG1sSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkTtNkBl[Xm| MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKExzMkGwJINmdGy|IHHmeIVzKDJiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLk[5JO69VS5? NXK1NlZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
MCF7 MkDqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlPjN{Bl[Xm| M4DENWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND61JO69VS5? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
MiaPaCa2 NG\sSFhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1jpSVMh\GG7cx?= M{\WfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTXnhVIFE[TJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvPSEQvF2u MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
SW620 M{HLe2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{XXOFMh\GG7cx?= M1;ZNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e2NlAh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuO{DPxE1w MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
HepG2 Mm\TRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NVjrTYF5OyCmYYnz M2XPcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuNkDPxE1w NV3TSYVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
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WI38 NX7oeHB4S3m2b4TvfIlkcXS7IHHzd4F6 MlzwN{Bl[Xm| NInCZ4lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUTN6IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOCEQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
HeLa NXHENGw{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEXxOWI{KGSjeYO= NVvJOYJJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOkDPxE1w M1fqd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEK0NVU2Lz5zOESyOFE2PTxxYU6=
Molt4/C8 NFfTe3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3G4SFMh\GG7cx?= MonFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPb3z0OE9EQCClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlAh|ryPLh?= NGPLTo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESyOFE2PSd-MUi0NlQyPTV:L3G+
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HepG2 NYX1XlJsS3m2b4TvfIlkcXS7IHHzd4F6 M1y4SlMh\GG7cx?= NYrq[mpzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwNzFOwG0v M2HqW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwPVI2Lz5{MkCwNFkzPTxxYU6=
BCG823 NVrZSI02S3m2b4TvfIlkcXS7IHHzd4F6 M2rE[VMh\GG7cx?= M2DZcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJETzh{MzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5zNTFOwG0v NEe1[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFkzPSd-MkKwNFA6OjV:L3G+
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HEK293 NH\5OI1EgXSxdH;4bYNqfHliYYPzZZk> M33ZUVIh\GG7cx?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDISWszQTNiY3XscJMh[W[2ZYKgNkBl[Xm|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyIE2gOFIvQSEQvF2u Ml35QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUO3OlEoRjJ{MEmzO|YyRC:jPh?=
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leukemia cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHz1N5U1QCCqcoO= MlT1S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBu\XSqb3SsJGdKPTBiPTCxOU4yKM7:TT6= M1\yN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUG5NVUyLz5{MkGxPVE2OTxxYU6=
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H460 NV;ycoxGS3m2b4TvfIlkcXS7IHHzd4F6 NY\vXYkyPzJiaILz M1naR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMh|ryPLh?= MmnpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzM{CxN|IoRjJ{MUOwNVMzRC:jPh?=
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MCF7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= MlPXO|IhcHK| MlfmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQh|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|MEGzNkc,OjJzM{CxN|I9N2F-
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QGY7701 NGPs[3lEgXSxdH;4bYNqfHliYYPzZZk> MlmyNlQhcHK| MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRS3k4PzBzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPC5|IN88UU4> MkTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOEK5NlYoRjJ{MUiyPVI3RC:jPh?=
SW480 M3L4U2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYOyOEBpenN? NYrlZ21JS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d2OECgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkexJO69VS5? NYLlOIZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxPFI6OjZpPkKyNVgzQTJ4PD;hQi=>
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CNE2 NETOUJVEgXSxdH;4bYNqfHliYYPzZZk> M1f6V|czKGi{cx?= NIX6bYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEVkV{IHPlcIx{KGGodHXyJFczKGi{czDufUBOXFRiYYPzZZktKEmFNUCgQUAyOy53IN88UU4> MkDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MEC0NFQoRjJ{MkCwOFA1RC:jPh?=
HepG2 NV[0VmZWSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{XFfVQ5KGi{cx?= NGrwflhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU46OiEQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJyOUS4Okc,OjJ{MEm0PFY9N2F-
NCI-H460 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MmfUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNuIFnDOVAhRSB6IN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{S1NUc,OjJ{OEO0OVE9N2F-
SMMC7721 MlewR5l1d3SxeHnjbZR6KGG|c3H5 MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyxiSVO1NEA:KDF3IN88UU4> M4Ds[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFUyLz5{MkK4N|Q2OTxxYU6=
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DU145 M4TwZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGrrRYQ4OiCqcoO= MnzaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzNjN{IN88UU4> NUTRelg5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PFc4PDVpPkKyOlg4PzR3PD;hQi=>
SGC7901 M3v0OmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3PE[FczKGi{cx?= NXe3WpJXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUSuOFkh|ryPLh?= NFjQ[I49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[4O|c1PSd-MkK2PFc4PDV:L3G+
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HepG2 NUXiVolOS3m2b4TvfIlkcXS7IHHzd4F6 Mn7VO|IhcHK| M2Xk[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Oi5{MjFOwG0v NGDiZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[4O|c1PSd-MkK2PFc4PDV:L3G+
NCI-H460 NHq4VlREgXSxdH;4bYNqfHliYYPzZZk> MlnrO|IhcHK| NFHLXZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj60JO69VS5? M1XIXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
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HepG2 MonuR5l1d3SxeHnjbZR6KGG|c3H5 MnyyO|IhcHK| NIToblhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC56IN88UU4> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
SGC7901 NUHOR295S3m2b4TvfIlkcXS7IHHzd4F6 NGDtRnE4OiCqcoO= MlrsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5|IN88UU4> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
MCF7 NY\Jend3S3m2b4TvfIlkcXS7IHHzd4F6 MVO3NkBpenN? M4H4NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzNjVizszNMi=> MojzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
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MCF7 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M2PB[VczKGi{cx?= MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOE4zKM7:TT6= NXrUN4pjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFkyQTJpPkKyO|Q6OTl{PD;hQi=>
CNE2 M365UGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX63NkBpenN? MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDUmUzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU4yKM7:TT6= NYjJZWgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFkyQTJpPkKyO|Q6OTl{PD;hQi=>
GLC82 NHPWVpVEgXSxdH;4bYNqfHliYYPzZZk> Ml;IO|IhcHK| NYjEXXR7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0yFOEKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5LkSg{txONg>? NHO0NZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
MGC803 NWPJZVZQS3m2b4TvfIlkcXS7IHHzd4F6 NX21dGNlPzJiaILz NWDRNHU1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOD61JO69VS5? M2PwRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{S5NVkzLz5{Mke0PVE6OjxxYU6=
MCF7 NFjoN45CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXPJSodIPzJiaILz Mk\wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bu\XSqb3SsJGlEPTBiPTC0Mlch|ryPLh?= NXX2eYRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OlU5QTdpPkKyO|Y2QDl5PD;hQi=>
HT-29 NITFSXdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4HJO|czKGi{cx?= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bu\XSqb3SsJGlEPTBiPTC3MlMh|ryPLh?= MlfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NkW4PVcoRjJ{N{[1PFk4RC:jPh?=
MDA-MB-231 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGLF[GU4OiCqcoO= M{DPWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegcYV1cG:mLDDJR|UxKD1iOT62JO69VS5? NXP4XmEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OlU5QTdpPkKyO|Y2QDl5PD;hQi=>
HT1080 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz6wOkDPxE1w NX;pOZBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
A375-S2 NYPUTWhvS3m2b4TvfIlkcXS7IHHzd4F6 MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN|c2NVN{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuPVIh|ryPLh?= NFjEUYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
HeLa M3ewNGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{KxNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuN|Yh|ryPLh?= MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
HepG2 NIXwWlVEgXSxdH;4bYNqfHliYYPzZZk> Mk\4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuOFUh|ryPLh?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
BGC823 M{\rN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NW\BW4R3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjZ3IN88UU4> MlLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
Hep2 NFLGNZJEgXSxdH;4bYNqfHliYYPzZZk> MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZAzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkW4JO69VS5? NHjFNYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NYLh[nFwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE42QCEQvF2u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
A549 MmjFR5l1d3SxeHnjbZR6KGG|c3H5 NVvqbWNYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNU42OiEQvF2u NELSXYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MDA231 M1nZe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEzOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{GuOVch|ryPLh?= NWiwVYJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
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A549 M1TtT2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2\PNVQ5KGi{cx?= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzOU41OSEQvF2u MlrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEm1OVgoRjJ{OEC5OVU5RC:jPh?=
MKN45 NUfrfoR7S3m2b4TvfIlkcXS7IHHzd4F6 MYC0PEBpenN? NGLnXWpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU052NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDFwN{Og{txONg>? MmfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEm1OVgoRjJ{OEC5OVU5RC:jPh?=
HepG2 MlnuR5l1d3SxeHnjbZR6KGG|c3H5 NYHtWGNZPDhiaILz MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NFyx[GE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwPVU2QCd-MkK4NFk2PTh:L3G+
LoVo NHXF[ndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3vwRlQ5KGi{cx?= NXzVS5NKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlMh|ryPLh?= NH\PWJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki0NFQ6Oyd-MkK4OFA1QTN:L3G+
A549 MnjmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2XsRlQ5KGi{cx?= Mle0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMj64JO69VS5? NVjPVYJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
MCF7 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF\KcYk1QCCqcoO= MknQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6yJO69VS5? NX\t[o1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
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HepG2 NInzU2JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXGwSFBQPDhiaILz NX7XS4t1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFEvOyEQvF2u NHzEUIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
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HCT116 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MoTVOFghcHK| MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4Njd4IN88UU4> NEfmeYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HT1080 NGHkcplEgXSxdH;4bYNqfHliYYPzZZk> NXLnRXBXPDhiaILz MkTmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQyODhyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{PS54MjFOwG0v NGO0[3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
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A549 M1nuPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFnSXZE1QCCqcoO= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0OE4xPSEQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
EC9706 MULDfZRwfG:6aXPpeJkh[XO|YYm= NULBUmJEPzJiaILz NYPBUGh3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTUN7N{C2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkOyJO69VS5? NEC5SJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFE6Oyd-MkO2OFQyQTN:L3G+
MGC803 MWrDfZRwfG:6aXPpeJkh[XO|YYm= M3znbFczKGi{cx?= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvOTRizszNMi=> NUTkdplWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQyQTNpPkKzOlQ1OTl|PD;hQi=>
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HCT116 NXrhZ2xTS3m2b4TvfIlkcXS7IHHzd4F6 MX60PEBpenN? Mm\jR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDJR|UxKD1iND61NkDPxE1w Ml;RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVUoRjJ|NkS0NlE2RC:jPh?=
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HCT116 NVXXTIs5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3nsPVczKGi{cx?= NHztfVhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU42OyEQvF2u M4fTSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nk[1NVA3Lz5{M{[2OVExPjxxYU6=
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ME180 MY\DfZRwfG:6aXPpeJkh[XO|YYm= MWW0PEBpenN? NU\yZXV4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUVzOECgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwOTFOwG0v NUfDenlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|I1QTdpPkK0N|MzPDl5PD;hQi=>
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Bel7402 MVLDfZRwfG:6aXPpeJkh[XO|YYm= MYS0JIRigXN? M2TFVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJmdDd2MEKgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNTFOwG0v NVjIU4xrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVk{ODNpPkK0N|U6OzB|PD;hQi=>
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HCT116 MYTDfZRwfG:6aXPpeJkh[XO|YYm= NYrUW|RqPDhiaILz M{PsOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS55ODFOwG0v NV71XFhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO|gzOTdpPkK0N|c5OjF5PD;hQi=>
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CNE MoPOR5l1d3SxeHnjbZR6KGG|c3H5 M13UZlQ5KGi{cx?= NFu0XI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEVkViY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQxNjJzIN88UU4> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN5OEKxO{c,OjR|N{iyNVc9N2F-
SPCA2 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M2[xO|Q5KGi{cx?= MmXkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3BESTJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjJizszNMi=> NETaeGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFIyPyd-MkSzO|gzOTd:L3G+
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leukemia MYDDfZRwfG:6aXPpeJkh[XO|YYm= MVuxNEB2VQ>? M2Hq[lQ5KGi{cx?= MoPSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhPDhiaILzMEBIUTVyIE2gNVUvOSEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR4OUGxNkc,OjR2NkmxNVI9N2F-
prostate cancer MmnjR5l1d3SxeHnjbZR6KGG|c3H5 NHPz[YEyOCC3TR?= M3i0OVQ5KGi{cx?= NFjVcXZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhPDhiaILzMEBIUTVyIE2gNlIvPyEQvF2u M{O3e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NE[5NVEzLz5{NES2PVEyOjxxYU6=
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EAC MoLZR5l1d3SxeHnjbZR6KGG|c3H5 M2f0TlQ5KGi{cx?= M4rBdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGVCSyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvOyEQvF2u M{frZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUO0OVM4Lz5{NEWzOFU{PzxxYU6=
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EAC MV\DfZRwfG:6aXPpeJkh[XO|YYm= NXPnTlIxPDhiaILz NH7zNZBEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBGSUNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJRzgXCjbjDicJVmKGW6Y3z1d4lwdiCjc4PhfUwhUUN3MDC9JFE3NjRizszNMi=> M2DXWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUO0OVM4Lz5{NEWzOFU{PzxxYU6=
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HepG2 M4jSfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGLIRXg1QCCqcoO= NFzqb2pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy54IN88UU4> M3[2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUS3O|k1Lz5{NEW0O|c6PDxxYU6=
HCT116 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NUDLd3prPDhiaILz MlXMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC52MzFOwG0v M1HsbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
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Bel7404 M1nrcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MoTMOFghcHK| MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB2IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPi56IN88UU4> MoTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NkW5NFUoRjJ2NU[1PVA2RC:jPh?=
HepG2 MVjDfZRwfG:6aXPpeJkh[XO|YYm= NVr0NXViPDhiaILz NH22bYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwOUig{txONg>? M2HzeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
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H3347 MlHuR5l1d3SxeHnjbZR6KGG|c3H5 NWnJVJFQPzJiaILz NFnJWmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJOzN2NzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQXzhcYFzKEKudXWgZZN{[XluIFnDOVAhRSBzMT62OEDPxE1w MornQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEOzOVUoRjJ2NUizN|U2RC:jPh?=
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Bcap37 Mm[0R5l1d3SxeHnjbZR6KGG|c3H5 MYG0PEBpenN? M4DYTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS5zODFOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV3NEmyNkc,OjV3NUS5NlI9N2F-
SGC7901 NIi2OFFEgXSxdH;4bYNqfHliYYPzZZk> NXjBXI9UPDhiaILz MmHzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi53NjFOwG0v NY\2Wng2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OVQ6OjJpPkK1OVU1QTJ{PD;hQi=>
BALB/3T3 NELzc2hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NELYNW44OiCqcoO= NUn5[Wt4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRWxDNzOWMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJI1mfGixZDygTWM2OCB;IEOuNlMh|ryPLh?= MlLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
LoVo MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXu3NkBpenN? M2DZNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFQvPjlizszNMi=> MknzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
doxorubicin-resistant LoVo/DX NGn0U2lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M37KS|czKGi{cx?= NWDpUZhoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhVG:Ybz;EXEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFYh|ryPLh?= M{LzTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
SW707 NGryVlFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MknQO|IhcHK| MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZN{C3JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gNlAvPDZizszNMi=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
vincristine-resistant HL60/Vinc M1f6UmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NX\6[FZDPzJiaILz NXvDfmg4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjD2bY5kemm|dHnu[U1z\XOrc4ThcpQhUEx4MD;WbY5kKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOS5zNTFOwG0v NVL4Z3FqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
HL60 NVvNWmJ[SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4DJOVczKGi{cx?= MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKyMlU1KM7:TT6= MluyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
HT-29 NUe3OZNMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXO3NkBpenN? NEXTXZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJibXX0bI9lNCCLQ{WwJF0hOjVwMEig{txONg>? NX7rXnB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
LS180 NFrQWWhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2LiZlczKGi{cx?= MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyVMUiwJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gN|gvQTJizszNMi=> M{nvbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
B16F10 MWTBcpRq[2GwY3XyJIF{e2G7 NWi4UmVSPzJiaILz M3nCUGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCNVZHOTBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkSzJO69VS5? NXrvU|hwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVU4OThpPkK1OlU2PzF6PD;hQi=>
MGC803 M4\Q[WFvfGmlYX7j[ZIh[XO|YYm= MnLRO|IhcHK| NUTTVWIxSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuOFMh|ryPLh?= NF30SII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
MCF7 M4e3V2FvfGmlYX7j[ZIh[XO|YYm= NE\4WZE4OiCqcoO= MW\BcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvOTJizszNMi=> NGjweVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
EC109 NFm4bllCdnSrY3HuZ4VzKGG|c3H5 NHS2Xmw4OiCqcoO= MmrnRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXDNVA6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwNkGg{txONg>? NGnw[FQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
HCT8 NVv4UlRFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoTXO|IhcHK| MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEigZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOUGg{txONg>? NGfkdHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[3OVE1PCd-MkW2O|UyPDR:L3G+
HCT8 M2T6[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEjMNHM4OiCqcoO= MkHDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDC1MWZWKHKnc3nzeIFvfCCqdX3hckBJS1R6IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Pi54M{ig{txONg>? M{LTXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nke1NVQ1Lz5{NU[3OVE1PDxxYU6=
MGC803 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NXv4PXgxPzJiaILz NUH0OpRRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD63NkDPxE1w MljEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEewNVIoRjJ3N{C3NFEzRC:jPh?=
MCF7 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NGm3RW44OiCqcoO= MmrxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVIvOjRizszNMi=> MmXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEewNVIoRjJ3N{C3NFEzRC:jPh?=
EC9706 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NYDxZWZQPzJiaILz MkfqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSWM6PzB4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPS54NzFOwG0v MmTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEewNVIoRjJ3N{C3NFEzRC:jPh?=
SMMC7721 M1jrSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWX5dY5XPzJiaILz NYHyRoJ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW02PQ{e3NlEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlQh|ryPLh?= M4DQUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{C3NFEzLz5{NUewO|AyOjxxYU6=
SW1573 NIXub5BCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVW0PEBpenN? NHT5RWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXNVU4OyClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDRwMzFOwG0v MlS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUK1NlUoRjJ3N{WyOVI2RC:jPh?=
HBL100 NGDNTFVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGnMdZg1QCCqcoO= NHPKT|ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjCUFExOCClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDVwNTFOwG0v M{n1XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{WyOVI2Lz5{NUe1NlUzPTxxYU6=
HeLa NUX4OXhlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmLIOFghcHK| NYDOZotZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hOTVizszNMi=> NVXIfI1rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVI2OjVpPkK1O|UzPTJ3PD;hQi=>
T47D MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUTVSotOPDhiaILz NUTWdGJYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hPDdizszNMi=> NELGfXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1NlUzPSd-MkW3OVI2OjV:L3G+
WiDr NEKxVJpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NELUPXQ1QCCqcoO= Mn:3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZaVTyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gOFkh|ryPLh?= Mm\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUK1NlUoRjJ3N{WyOVI2RC:jPh?=
MGC803 NUTSU29NSW62aXPhcoNmeiCjc4PhfS=> M2LqOlQ5KGi{cx?= M2jzdWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{42QCEQvF2u NFfLNow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNlk3Pid-MkW4NVI6PjZ:L3G+
SMMC7721 NGOycmNCdnSrY3HuZ4VzKGG|c3H5 NYqxbopIPDhiaILz NGq5T2FCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC|dYL2bZZidCCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC56NzFOwG0v M3rr[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEGyPVY3Lz5{NUixNlk3PjxxYU6=
HepG2 MUPBcpRq[2GwY3XyJIF{e2G7 NHHBO|A1QCCqcoO= NF3mcWFCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU45PiEQvF2u MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzMkm2Okc,OjV6MUK5OlY9N2F-
SGC7901 M4L3[mFvfGmlYX7j[ZIh[XO|YYm= NVPaNGlQPDhiaILz NEDZNJBCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA3NjF{IN88UU4> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzMkm2Okc,OjV6MUK5OlY9N2F-
SKOV3 M1TOOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3PzOFIh\GG7cx?= NXHKZ2NsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5LkO0JO69VS5? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2MUG5Okc,OjV6NEGxPVY9N2F-
HepG2 NIPZV|ZEgXSxdH;4bYNqfHliYYPzZZk> MVqyJIRigXN? NVXCUmpKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNzLkm4JO69VS5? M1[1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OESxNVk3Lz5{NUi0NVE6PjxxYU6=
A549 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MkCyNkBl[Xm| M4THT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM5NjJ|IN88UU4> NHTsNWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi0NVE6Pid-MkW4OFEyQTZ:L3G+
T24 NE\UbpFEgXSxdH;4bYNqfHliYYPzZZk> MXuyJIRigXN? NITZd|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVOjRiY3XscJMh[W[2ZYKgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQxNjV5IN88UU4> NXvHNHVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTZpPkK1PFQyOTl4PD;hQi=>
SPCA2 M{HQbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUWyJIRigXN? M3vycmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNRS0F{IHPlcIx{KGGodHXyJFIh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUA1PC5zIN88UU4> Mn7EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEGxPVYoRjJ3OESxNVk3RC:jPh?=
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MGC803 Ml7GR5l1d3SxeHnjbZR6KGG|c3H5 M{jHbVIh\GG7cx?= M{ToWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjZoTldkAzKGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDdwM{mg{txONg>? NFjjPZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi0NVE6Pid-MkW4OFEyQTZ:L3G+
HCT116 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NGq4XFU1QCCqcoO= MkfZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzQS53ODFOwG0v NVnmeI1LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTlpPkK1PFQyOTl7PD;hQi=>
HepG2 MUnDfZRwfG:6aXPpeJkh[XO|YYm= M3nXSlQ5KGi{cx?= NULYWHg3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyLke5JO69VS5? NVW0XlB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTlpPkK1PFQyOTl7PD;hQi=>
A549 MVvDfZRwfG:6aXPpeJkh[XO|YYm= MWq0PEBpenN? NYfWSohkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzZwM{Sg{txONg>? M4jjUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OESxNVk6Lz5{NUi0NVE6QTxxYU6=
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MGC803 NIDmXWtEgXSxdH;4bYNqfHliYYPzZZk> MlnZOFghcHK| M1PjXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwOUSg{txONg>? NYfGN|RsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTlpPkK1PFQyOTl7PD;hQi=>
MDA-MB-231 M4ThRmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1O4XFQ5KGi{cx?= NY\iPHNoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU45OiEQvF2u M3;Ve|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEewNVMyLz5{NUi3NFE{OTxxYU6=
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A549 M2jMfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX20PEBpenN? MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlUyKM7:TT6= NEXKWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3NFE{OSd-MkW4O|AyOzF:L3G+
A549 M2HJcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIrTcZM4OiCqcoO= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVEigZZN{[XluIFnDOVAhRSB{Lkig{txONg>? M1;GdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUG5NFUzLz5{NUmxPVA2OjxxYU6=
PANC1 NILqT5lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Ml7yO|IhcHK| MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCDTlOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iMz63JO69VS5? M{W2S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUG5NFUzLz5{NUmxPVA2OjxxYU6=
PSN1 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWO3NkBpenN? NGHxNG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDTUlEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTC0MlQh|ryPLh?= NYHlUmxORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5NVkxPTJpPkK1PVE6ODV{PD;hQi=>
MDA-MB-231 NU\GUZZuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEjCNm04OiCqcoO= M4LVUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhX1OWODDhd5NigSxiSVO1NEA:KDVwMjFOwG0v MoqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7MUmwOVIoRjJ3OUG5NFUzRC:jPh?=
HeLa M1T1PWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVS3NkBpenN? MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVEigZZN{[XluIFnDOVAhRSB3Lkig{txONg>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTlzOUC1Nkc,OjV7MUmwOVI9N2F-
TIG3 Mm\SRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYO3NkBpenN? NE\jVmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGTJS|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTC4MlQh|ryPLh?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTlzOUC1Nkc,OjV7MUmwOVI9N2F-
HeLa Ml7pRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnnhOFghcHK| NW\LW4RjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IFPDT|gh[XO|YYmsJGlEPTBiPTC4Mlk{KM7:TT6= NIrpS449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm1PVgyOyd-MkW5OVk5OTN:L3G+
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Bel7402 NX3JZ2d2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{fPSFQ5KGi{cx?= NInOfINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44hcW6ldXLheIVlKG[xcjC0PEBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFE6NjlzIN88UU4> MonKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7NUm4NVMoRjJ3OUW5PFE{RC:jPh?=
NIH/3T3 NEDOXnJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWD2fYZHPDhiaILz NHTiO2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIF7JTE8{XDNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44hcW6ldXLheIVlKG[xcjC0PEBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFIzNjN4IN88UU4> NUjIT5lTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5OVk5OTNpPkK1PVU6QDF|PD;hQi=>
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HepG2 Mo\6R5l1d3SxeHnjbZR6KGG|c3H5 MYC0PEBpenN? NHjRd5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQCEQvF2u MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl4OUG3NUc,OjV7NkmxO|E9N2F-
L1210 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckwhUUN3MDC9JFAvOzNizszNMi=> NXzOU5pkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFE{PDRpPkK2NFAyOzR2PD;hQi=>
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CEM M{jkcGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3PtemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNGVSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckwhUUN3MDC9JFE5KM7:TT6= NXznW|VJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFE{PDRpPkK2NFAyOzR2PD;hQi=>
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HCT116 M2DFdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWnIVGxZPDhiaILz NIm2RYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IIP1cJBpd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwJF0hPC53IN88UU4> M1HvU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkKyOFQ6Lz5{NkKyNlQ1QTxxYU6=
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HaCaT NXjuXWxoS3m2b4TvfIlkcXS7IHHzd4F6 NIeyc241QCCqcoO= M3PwU2N6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjhR4FVKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU4zPiEQvF2u NHntXlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzNVA5OCd-Mk[yN|ExQDB:L3G+
Hep3B MoezR5l1d3SxeHnjbZR6KGG|c3H5 M13HdVIh\GG7cx?= M2nl[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPSEQvF2u MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OUiwNkc,OjZ{NUm4NFI9N2F-
Bcap37 NWO0U3BKS3m2b4TvfIlkcXS7IHHzd4F6 M36w[|Ih\GG7cx?= MmHRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoNieDN5IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFUvPThizszNMi=> NXu3UmVLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVk5ODJpPkK2NlU6QDB{PD;hQi=>
MCF7 MXrDfZRwfG:6aXPpeJkh[XO|YYm= NXnBeJN4OiCmYYnz MoLiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBqdmO3YnH0[YQh\m:{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNU42KM7:TT6= NHnTPWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PVgxOid-Mk[yOVk5ODJ:L3G+
HepG2 NWfFXIRYS3m2b4TvfIlkcXS7IHHzd4F6 NH;ndXczKGSjeYO= M4TlXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQxNjN2IN88UU4> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OUiwNkc,OjZ{NUm4NFI9N2F-
A549 NFvzSVFEgXSxdH;4bYNqfHliYYPzZZk> MlS4NkBl[Xm| M13CXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJINmdGxiZHXheIghcW6ldXLheIVlKG[xcjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFQvODVizszNMi=> NV3Y[2ZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVk5ODJpPkK2NlU6QDB{PD;hQi=>
SW620 NE\SU5VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXSzSIZ1PzJiaILz NWS4e4RqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlc6KM7:TT6= M1zoS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkmxNFM5Lz5{NkK5NVA{QDxxYU6=
MIAPaCa2 NGD2WlBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3LmSVczKGi{cx?= NF:1fpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEyNjZ5IN88UU4> NYfPeXNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
MCF7 MlvERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFzNUnI1QCCqcoO= NYDWTFk1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlAyOiEQvF2u NVnlR4t1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNFE2PThpPkK2N|AyPTV6PD;hQi=>
DU145 Mnv4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUK0PEBpenN? MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4LkC3NkDPxE1w MlHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MEG1OVgoRjJ4M{CxOVU5RC:jPh?=
A549 NWjHe3h3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkfqOFghcHK| NITEVZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNlQ1KM7:TT6= MmPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MEG1OVgoRjJ4M{CxOVU5RC:jPh?=
HeLa NH\QUIJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUm0PEBpenN? M{i3[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD6zNVch|ryPLh?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNyMUW1PEc,OjZ|MEG1OVg9N2F-
MCF7 NX7yUGM{S3m2b4TvfIlkcXS7IHHzd4F6 MlrJOFghcHK| NUTQOYVLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwM{mg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN4M{i2PUc,OjZ|NkO4Olk9N2F-
A549 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MlO2OFghcHK| NIjxe2FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOi5{ODFOwG0v NEDZcJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO2N|g3QSd-Mk[zOlM5Pjl:L3G+
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HepG2 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MlfPOFghcHK| MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NYq1TFluRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zOlM5PjlpPkK2N|Y{QDZ7PD;hQi=>
HT-29 M{XhVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NInwbGg1QCCqcoO= MmrZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMUWuPFMh|ryPLh?= NX3IeXI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NVM4OjVpPkK2OFE{PzJ3PD;hQi=>
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BT549 M4X0TmFvfGmlYX7j[ZIh[XO|YYm= Mnv2OFghcHK| MmDNRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU45OiEQvF2u NGDUZms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSxN|czPid-Mk[0NVM4OjZ:L3G+
DU145 MXTBcpRq[2GwY3XyJIF{e2G7 MlTzOFghcHK| Mn;CRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPU4yPyEQvF2u NUe0ZmlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NVM4OjZpPkK2OFE{PzJ4PD;hQi=>
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Hep3B M1y4Z2N6fG:2b4jpZ4l1gSCjc4PhfS=> M13UZ|Q5KGi{cx?= MnXkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjV|IN88UU4> M{P4RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEizNVQ5Lz5{Nki4N|E1QDxxYU6=
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HT-29 MUfBcpRq[2GwY3XyJIF{e2G7 M3;KZlQ5KGi{cx?= MVnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUh|ryPLh?= Mm\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyN|MoRjJ4OUKyNlM{RC:jPh?=
HCT116 M3HGWmFvfGmlYX7j[ZIh[XO|YYm= NXuxXJQ5PzJiaILz M1v5UWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwODFOwG0v NGi2T2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlI{Oyd-Mk[5NlIzOzN:L3G+
RKO MUnBcpRq[2GwY3XyJIF{e2G7 MnfPOFghcHK| MYjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUlvPJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESxMlEh|ryPLh?= NID0dXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlI{Oyd-Mk[5NlIzOzN:L3G+
KB M1fmdWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX3qfJJ6PzJiaILz M4O4c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC0Mlg1KM7:TT6= MoPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
HeLa M2rtfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYm5OHRQPzJiaILz NWnWWGF{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi5{MzFOwG0v NHnMS4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
MCF7 NH7mfmNEgXSxdH;4bYNqfHliYYPzZZk> Mlj0O|IhcHK| MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IE[uOVMh|ryPLh?= M{jUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
HepG2 NYX3OmhVS3m2b4TvfIlkcXS7IHHzd4F6 Mn;CO|IhcHK| MmLLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFYvPiEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
HDF NHj4PXNEgXSxdH;4bYNqfHliYYPzZZk> Ml;CO|IhcHK| NIfz[|NEgXSxdH;4bYNqfHliYXfhbY5{fCCKRF[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDdwMEKg{txONg>? NFLFTlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
143B MknDR5l1d3SxeHnjbZR6KGG|c3H5 NGfIXHo4OiCqcoO= MojyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVQ{SiClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVMvODFizszNMi=> MnjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
thymidine kinase deficient 143B MXXDfZRwfG:6aXPpeJkh[XO|YYm= Mn\sO|IhcHK| NVXNRph1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhOTR|QjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOTZwM{Gg{txONg>? M{\tNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
U87MG MoTXR5l1d3SxeHnjbZR6KGG|c3H5 MkLlO|IhcHK| M2\5c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5P02JIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliWkKgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDF6LkK1JO69VS5? NV;VRWVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPFE4PDJpPkK3NFgyPzR{PD;hQi=>
PC3 NGHMR4VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIrzOYY1QCCqcoO= MnT4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwN{[g{txONg>? MnPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOUK0NVMoRjJ5MEmyOFE{RC:jPh?=
HT-29 MorMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHLEXWc1QCCqcoO= NU\McXhsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk45KM7:TT6= NInKOZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C5NlQyOyd-MkewPVI1OTN:L3G+
U87MG NV7QcmZ3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MUm0PEBpenN? MkCwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz62OUDPxE1w M3PGPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
A549 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2W5e|Q5KGi{cx?= M3LhS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz65PEDPxE1w NWjxTYoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
HaCaT M16zTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEi3PVQ1QCCqcoO= NEjtTY5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjhR4FVKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOk4yPSEQvF2u NV3qXnpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
MGC803 NV3aUW5nSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml2zO|IhcHK| NVP5cWk{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4zPSEQvF2u NIPFcXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
EC109 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYW3NkBpenN? NEX6bYdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXDNVA6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNVch|ryPLh?= M1HEWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
SH-SY5Y NGPnTHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlHJO|IhcHK| MmXPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNlYh|ryPLh?= MlTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
U87 M{mwT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYTxd2YxPzJiaILz NYK2[mJLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFch[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT62NUDPxE1w MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyNUCyPEc,OjdzMEWwNlg9N2F-
MCF7 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHjiSpc4OiCqcoO= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy54MTFOwG0v NVXpZmd1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNFUxOjhpPkK3NVA2ODJ6PD;hQi=>
MDA-MB-231 NUnzPHpNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1[w[FQ5KGi{cx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjZizszNMi=> MmXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixPFAoRjJ5MUK4NVgxRC:jPh?=
MCF7 NXTFNXN{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NH2yRW01QCCqcoO= M4PI[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{CuOFEh|ryPLh?= MnnNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixPFAoRjJ5MUK4NVgxRC:jPh?=
A549 M{nOdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF32WZk1QCCqcoO= M1L3RWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuOFEh|ryPLh?= M2PTflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
HepG2 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUm0PEBpenN? MlfqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNE[uPFMh|ryPLh?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG4NEc,OjdzMkixPFA9N2F-
MCF7 NVHjSIRFS3m2b4TvfIlkcXS7IHHzd4F6 NWrVR4xWPDhiaILz MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{42KM7:TT6= NHnjS5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
Bcap37 M4nHXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{HYb|Q5KGi{cx?= M2KyW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTVwNEeg{txONg>? NIridoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
Hep3B Moq3R5l1d3SxeHnjbZR6KGG|c3H5 MoC3OFghcHK| MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVcvPTNizszNMi=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
A549 M17SfmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4T4OFQ5KGi{cx?= NUW4Z3FiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjFwNUig{txONg>? Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
U251 NUnofpJbS3m2b4TvfIlkcXS7IHHzd4F6 MVy0PEBpenN? M2XSTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzPTFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjZ7IN88UU4> MoTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
HepG2 M17ZNWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml3qOFghcHK| MlPsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI2NjF5IN88UU4> NV;mWZRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexN|M2QTNpPkK3NVM{PTl|PD;hQi=>
LNCAP M3zI[WN6fG:2b4jpZ4l1gSCjc4PhfS=> NHK3R|czPCCqcoO= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkAzPCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IECuNFMh|ryPLh?= NGfTZpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G1Olc4OCd-MkexOVY4PzB:L3G+
PC3 MlWwR5l1d3SxeHnjbZR6KGG|c3H5 NV[2d2VyOjRiaILz M3TxWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkAzPCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IECuNFMh|ryPLh?= NEDv[3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G1Olc4OCd-MkexOVY4PzB:L3G+
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A549 M2TmR2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYrwR3NvPzJiaILz MnWzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk45KM7:TT6= NHrVWHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
SGC7901 Ml[2R5l1d3SxeHnjbZR6KGG|c3H5 M{W3SlczKGi{cx?= MkDrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwOTFOwG0v MnPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3M{e5NlQoRjJ5NUO3PVI1RC:jPh?=
MDA-MB-435S NGT5NW1EgXSxdH;4bYNqfHliYYPzZZk> MWG3NkBpenN? MlPDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlIh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV|N{myOEc,Ojd3M{e5NlQ9N2F-
PC3 M4jQOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVi5cYxmPzJiaILz NILMSoZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjVizszNMi=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV|N{myOEc,Ojd3M{e5NlQ9N2F-
colon cancer cell NILHdVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFXYNpE1QCCqcoO= MYfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEiuOEDPxE1w MnjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUS0OFQoRjJ5NUW0OFQ1RC:jPh?=
leukemia cell M4TxSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVy0PEBpenN? Ml;TS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDF3LkGg{txONg>? NVjVc2FFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OVQ1PDRpPkK3OVU1PDR2PD;hQi=>
prostate cancer cell NGrNSYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWPhdo9CPDhiaILz MnXWS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAzOi55IN88UU4> M4ew[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUW0OFQ1Lz5{N{W1OFQ1PDxxYU6=
renal cancer cell NX3ROGljT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXG0PEBpenN? NVT6c2hTT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA1PS54IN88UU4> NGq2d5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W1OFQ1PCd-Mke1OVQ1PDR:L3G+
DU145 M4DPZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlzaOFghcHK| MkiwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nj6xJO69VS5? NY[wXmRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
HeLa Mkj2R5l1d3SxeHnjbZR6KGG|c3H5 M17SelQ5KGi{cx?= NGnzd2tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuNkDPxE1w M37adFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E5Lz5{N{W2NVcyQDxxYU6=
IOSE-144 MnrmR5l1d3SxeHnjbZR6KGG|c3H5 NX\Pd|Z{PDhiaILz NUP0fFNOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUU:VRT2xOFQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Pi5zIN88UU4> NE\KSYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W2NVcyQCd-Mke1OlE4OTh:L3G+
HepG2 MULDfZRwfG:6aXPpeJkh[XO|YYm= MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwMzFOwG0v M3j3Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
DU145 NIn3S3BEgXSxdH;4bYNqfHliYYPzZZk> M13md2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT62JO69VS5? M36xNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
MDA-MB-231 MnvlR5l1d3SxeHnjbZR6KGG|c3H5 MoD2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvQCEQvF2u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV4MUexPUc,Ojd3NkG3NVk9N2F-
HeLa MW\DfZRwfG:6aXPpeJkh[XO|YYm= M13tPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkmg{txONg>? MnH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVkoRjJ5NU[xO|E6RC:jPh?=
SW780 MoDuR5l1d3SxeHnjbZR6KGG|c3H5 Mni5O|IhcHK| Mlv4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c4QDBiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSB4Lkm5JO69VS5? NVHqVm86RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
MGC803 NXfTSVVUS3m2b4TvfIlkcXS7IHHzd4F6 M2nxUVczKGi{cx?= MmLPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUCuOlQh|ryPLh?= NV3NVW9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
HL-7702 M2LP[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MWq3NkBpenN? NVPHO2EyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUExvN{ewNkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFEzNjh3IN88UU4> NVTuNWVXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
MCF7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= Ml;CO|IhcHK| M3TJZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSBzMz6xPUDPxE1w NFzyW289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W5O|QyOSd-Mke1PVc1OTF:L3G+
GES-1 MlryR5l1d3SxeHnjbZR6KGG|c3H5 M2fpNVczKGi{cx?= NIn4XI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBITVNvMTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IEGzMlc2KM7:TT6= M2HFO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
TE1 M2TDc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVvnbW1oPzJiaILz NGWxco1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVTTFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSBzNz6zNkDPxE1w NWKxemN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
A549 M2O5VmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWm0PEBpenN? M2jpd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|AvPDdizszNMi=> NHHzWnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQxQCd-Mke2NVQ1ODh:L3G+
MDA-MB-231 MlKzR5l1d3SxeHnjbZR6KGG|c3H5 MVm0PEBpenN? NH7p[2ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1Mlk5KM7:TT6= M4nkO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkG0OFA5Lz5{N{[xOFQxQDxxYU6=
DU145 NWrCcGp1S3m2b4TvfIlkcXS7IHHzd4F6 NYfNUlFNPDhiaILz NESxelNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OC53ODFOwG0v NYn6XVZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
PC3 M1THZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWnh[nNsPDhiaILz NWjXVZNJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ2NjN{IN88UU4> NFzFSmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQxQCd-Mke2NVQ1ODh:L3G+
MCF7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= M1HKSFQ5KGi{cx?= NVrU[Y5JS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxKD1iND61JO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ6OEG4OEc,Ojd4OEixPFQ9N2F-
HepG2 NGrqNpZHfW6ldHnvckBie3OjeR?= MmTCOFghcHK| M4Sx[mhmeGG2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IEeg{txONg>? NEDocW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE5PCd-Mke2PFgyQDR:L3G+
U87 NHnTXYxHfW6ldHnvckBie3OjeR?= MnPEOFghcHK| MXnO[ZVzd3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEeLNUCgQUAyOyEQvF2u Ml7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OEixPFQoRjJ5Nki4NVg1RC:jPh?=
HCT116 M1OwdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVm3NkBpenN? NXXKPGh3T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB{LkWg{txONg>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEixNUc,Ojd5MES4NVE9N2F-
HeLa M4Dic2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXfDUGgxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGK7IF3UWEBie3OjeTygTWM2OCB;IEGuOkDPxE1w M3jvN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{KwNlk3Lz5{N{eyNFI6PjxxYU6=
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HepG2 NGG2c3FEgXSxdH;4bYNqfHliYYPzZZk> MmHoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkig{txONg>? M33DZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{KwNlk3Lz5{N{eyNFI6PjxxYU6=
MDA-MB-231 NGjNOJpEgXSxdH;4bYNqfHliYYPzZZk> NV\JPFRpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwOTFOwG0v NIrn[2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{eyNFI6Pid-Mke3NlAzQTZ:L3G+
L1210 MlzKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGDne241QCCqcoO= MlPKRY51cS2ycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEmFNUCgQUAxNjN|IN88UU4> NV3FXZA6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
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A549 NWLIOW5YS3m2b4TvfIlkcXS7IHHzd4F6 NH\BUW9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{Njl3IN88UU4> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OUCzOEc,Ojd5NkmwN|Q9N2F-
EC109 MlvGR5l1d3SxeHnjbZR6KGG|c3H5 M{XyUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVEOTB7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI2Njl7IN88UU4> MmfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|QoRjJ5N{[5NFM1RC:jPh?=
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EC109 NF\4RppCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmXDO|IhcHK| M2Sw[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRVOxNFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlU6KM7:TT6= MnHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{G1PVkoRjJ5N{exOVk6RC:jPh?=
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QBC939 M1rpfWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUeyOEBpenN? MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRRmM6OzliY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkGg{txONg>? MmHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MkW3OlMoRjJ5OEK1O|Y{RC:jPh?=
SW620 M1vSOWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{XXd|czKGi{cx?= NFfyRoFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOlIxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlA5KM7:TT6= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh5NUe3PUc,Ojd6N{W3O|k9N2F-
CFPAC-1 MkPyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NES3cY04OiCqcoO= NHTreGVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPGVGFENTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTRizszNMi=> NXLx[IdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
WI38 MkWxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1;lR|czKGi{cx?= NUXFTWFISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDXTVM5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlk1KM7:TT6= NIDneZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
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Hep3B NGHCNmhEgXSxdH;4bYNqfHliYYPzZZk> M4\WWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6zOkDPxE1w M4LpdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUGzNVc6Lz5{N{mxN|E4QTxxYU6=
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WISH MXzDfZRwfG:6aXPpeJkh[XO|YYm= MWeyOEBpenN? MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXTXNJKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy5zIN88UU4> MlzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NUG0PFcoRjJ5OUWxOFg4RC:jPh?=
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HepG2 NEnoTG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\uNlQhcHK| MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvQDdizszNMi=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDBzMUKyNEc,OjhyMUGyNlA9N2F-
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MGC803 NV:1dVE5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NV3kdoU1PzJiaILz M3:3VmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlEzKM7:TT6= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF4NUezPEc,OjhzNkW3N|g9N2F-
K562 NVPnRmFDSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml\xO|IhcHK| NV7hTHp2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlU1KM7:TT6= NWK0[5JjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
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HepG2 MlT1R5l1d3SxeHnjbZR6KGG|c3H5 MYSyOEBpenN? NEDwTYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS52IN88UU4> NXrwOJBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOVQ3QTdpPkK4NlU1Pjl5PD;hQi=>
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HepG2 MlrLR5l1d3SxeHnjbZR6KGG|c3H5 MnXWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj6xJO69VS5? MkPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NkK1NlcoRjJ6Mk[yOVI4RC:jPh?=
Hep3B MVzDfZRwfG:6aXPpeJkh[XO|YYm= MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Lk[2JO69VS5? NVnvUY1xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOlI2OjdpPkK4NlYzPTJ5PD;hQi=>
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HeLa M{\HZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkXSOFghcHK| NUntOIpZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlAzKM7:TT6= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN4M{S0OEc,Ojh|NkO0OFQ9N2F-
HepG2 NUXqeJhHSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkPhOFghcHK| MkLCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUOuN|Eh|ryPLh?= NIPQZpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
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A549 MnH4R5l1d3SxeHnjbZR6KGG|c3H5 NULMWVR2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPE4zKM7:TT6= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN5MU[3Okc,Ojh|N{G2O|Y9N2F-
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A549 M3K3eGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVzodHM3PDhidH:gO|IhcHK| MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiaX7jeYJifGWmIH\vdkA1QCC2bzC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPjVizszNMi=> Ml\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OUWyNVgoRjJ6M{m1NlE5RC:jPh?=
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A549 NUSwT3F{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{TXV|Q5KGi{cx?= MoPKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6xJO69VS5? NUnB[FBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzhpPkK4OFAxOjN6PD;hQi=>
HepG2 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYC0PEBpenN? Mlq1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCuNUDPxE1w NXvSWpo1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzhpPkK4OFAxOjN6PD;hQi=>
HCT116 M1vZ[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnXyOFghcHK| M1fnWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOk4zKM7:TT6= NYDOcmpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzhpPkK4OFAxOjN6PD;hQi=>
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HepG2 M{LOVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGqwPXFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiSVO1NEA:KDhwMTFOwG0v M1LLRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOxN|QyLz5{OESzNVM1OTxxYU6=
HCT116 MmS5R5l1d3SxeHnjbZR6KGG|c3H5 NF\DSGNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNuIFnDOVAhRSB7Lkmg{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUO0NUc,Ojh2M{GzOFE9N2F-
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HGC27 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlfFO|IhcHK| MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiJQ{K3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkKyJO69VS5? M3fiTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEW2NFMyLz5{OES1OlA{OTxxYU6=
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HCT116 NGe4d4dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXzhclY2PzJiaILz MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND6xOkDPxE1w MlXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUixN|MoRjJ6NEW4NVM{RC:jPh?=
PC3 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFqzVFA4OiCqcoO= NV3SOIVGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlM{KM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3OEGzN{c,Ojh2NUixN|M9N2F-
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HepG2 NFLle|hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIG2eoI4OiCqcoO= MlroRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNFch|ryPLh?= NXPXZYc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVgyOzNpPkK4OFU5OTN|PD;hQi=>
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HeLa NIL5fpFEgXSxdH;4bYNqfHliYYPzZZk> NUixUWhYPzJiaILz NX7zfo5vS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTCxN{46KM7:TT6= NWOybmpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFg5PjJpPkK4OFg5QDZ{PD;hQi=>
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HepG2 NWHkPJlXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Moe4O|IhcHK| Mm\mRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNUDPxE1w NFHHWpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2OSd-Mki0PVQzPTF:L3G+
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HL60 M4T0PWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2jkS|I1KGi{cx?= M1HaOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczD0doVifGWmIH\vdkAzPCCqcoOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuOlkh|ryPLh?= NUT1SZNbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|c6PTFpPkK5NFM4QTVzPD;hQi=>
THP1 MnjURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWKyOEBpenN? NFL6b5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGTIVFEh[2WubIOgeJJm[XSnZDDmc5IhOjRiaILzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Mlg4KM7:TT6= M{XUN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEO3PVUyLz5{OUCzO|k2OTxxYU6=
PC3 Mk\pRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHfkWI8zPCCqcoO= NYm1Rnh{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgeJJm[XSnZDDmc5IhOjRiaILzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyN{46PCEQvF2u NUm2NoFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|c6PTFpPkK5NFM4QTVzPD;hQi=>
HepG2 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2TFW|I1KGi{cx?= NV3FPYRrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{B1emWjdHXkJIZweiB{NDDodpMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjR6IN88UU4> M4jjd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEO3PVUyLz5{OUCzO|k2OTxxYU6=
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K562 NH\ZN5BCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3jBT|Q5KGi{cx?= MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NEA:KDF6LkWg{txONg>? NUPhUWFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwOFA6PTRpPkK5NFQxQTV2PD;hQi=>
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EC109 MnrMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWK3eXVjPDhiaILz NWjSRnp5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5{MTFOwG0v NW\sOGZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNVM4PDVpPkK5NVE{PzR3PD;hQi=>
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HL60 NWOyRWVnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1\xT|czKGi{cx?= NInUW2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IITyfZBp[W5iYnz1[UB{fGGrbnnu[{Bj[XOnZDDo[Y1ifG:leYTvcYV1emmlIH3leIhw\CxiSVO1NEA:KDJwODFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|MU[xOkc,OjlzM{G2NVY9N2F-
PC3 M136emFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkDSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlIvODJizszNMi=> NVX3UVJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|E3OTZpPkK5NVMyPjF4PD;hQi=>
EAC NV21[GhES3m2b4TvfIlkcXS7IHHzd4F6 MVq0PEBpenN? NXX6b41RS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhTUGFIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6yJO69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|M{CzO{c,OjlzM{OwN|c9N2F-
EAC MYLDfZRwfG:6aXPpeJkh[XO|YYm= M1HhS|Q5KGi{cx?= NIfLOYREgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBGSUNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSC2conwZY4h[my3ZTDlfINtfXOrb36gZZN{[XluIFnDOVAhRSB7Lk[g{txONg>? NYXjR2E3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxOzdpPkK5NVM{ODN5PD;hQi=>
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DLA Mnn2R5l1d3SxeHnjbZR6KGG|c3H5 MoPsOFghcHK| NFTGTJBEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBFVEFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSC2conwZY4h[my3ZTDlfINtfXOrb36gZZN{[XluIFnDOVAhRSBzMD62JO69VS5? NVHyVHB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxOzdpPkK5NVM{ODN5PD;hQi=>
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A549