Fluorouracil (5-Fluorouracil, 5-FU)

For research use only.

Catalog No.S1209 Synonyms: NSC 19893

116 publications

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

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Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 116 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPG[lNoPzMEoHlCpC=> MX\JR|UxRiB{NTFOwIcwdUx? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
HL-60 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzQbVY4OsLiaNMg MnnNTWM2OD16Lk[wNUDPxGdxbVy= NWHSTId3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HT-29 NHfjSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PNXlczyqCqwrC= MoC0TWM2OD5iMkWg{txoN22O M3vXT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
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CCRF-CEM NYCyd5RQTnWwY4Tpc44h[XO|YYm= NUfuZo9mTW[oZXP0JI9vKEOFUl[tR2VOKGOnbHzzJIlvKGO3bIT1doUtKEmFNUCgQUAzKM7:TT6= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ{Mke4K|4zOzZ{Mke4QE9iRg>?
P388 NUXne|FnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX;vboZUPDhiaILz NXjL[Hg2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDQN|g5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlYxQSEQvF2u NF\aXoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e4OFQ6Lz5{N{e4OFQ6RC:jPh?=
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SW480 NXvESpl7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWjzeWpMPzJiaILz NX\EfZBMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFgvOSEQvF2u NEPBSpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
MDA-MB-435S Mn;NRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmnqO|IhcHK| MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01OzWVIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRibXX0bI9lNCCLQ{WwJF0hOTRwNTFOwG0v M1PkN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUK0OlU2Lz5zN{WyOFY2PTxxYU6=
HCCLM7 M17N[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGGxbG04OiCqcoO= NFLIVmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDR2xOPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFE5NjZizszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV{NE[1OUc,OTd3MkS2OVU9N2F-
Caco-2 NHPrcGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;zN2xYT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS2Glbz2yJINmdGy|LDDJR|UxKD1iMT61JO69VS5? M1XEbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUS4NVI6Lz5zN{W0PFEzQTxxYU6=
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HCT116 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mk\JO|IhcHK| MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUAzNjhizszNMi=> NHLKZmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
SW480 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXW3NkBpenN? MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNEiwJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3MDC9JFMvPSEQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
SW48 MlHyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn[2O|IhcHK| NV\2fZRkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDVwMzFOwG0v NEf5VJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
DLD1 NYj0R5YzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2T4bWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRNTDFiY3XscJMtKEmFNUCgQUA1NjVizszNMi=> NUDXOXZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVM3QDVpPkG3OVU{Pjh3PD;hQi=>
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L1210 MnTBR5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= M1Xae2N6fG:|dHH0bYMh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{whUUN3MDC9JFAvOjhizszNMi=> NFT0S|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mzNVg3Oid-MUe5N|E5PjJ:L3G+
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Caco-2 NUGyNHJqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVOxNEBl[Xm| MXPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgNVAh\GG7czygTWM2OCB;IEGuOUDPxE1w M4f3OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEO3NVk2Lz5zOECzO|E6PTxxYU6=
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embryonic cell M1;HTGZ2dmO2aX;uJIF{e2G7 MUTJcoR2[3Srb36gc4Yh[2ynYY\h[4Uh[XK{ZYP0JIlvKGWvYoL5c45q[yClZXzsd{Bw\iC|dHHn[UA5KFinbn;weZMhdGGndnnzJIJt[XO2dXzh[UwhUUN3MDC9JFI3NjhizszNMi=> M{XYS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkexOVU5Lz5zOEK3NVU2QDxxYU6=
HepG2 NXTT[mtkS3m2b4TvfIlkcXS7IHHzd4F6 M{P2T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{NCCLQ{WwJF0hOThwNzFOwG0v NVvPS|dpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFI{OzZpPkG4N|AzOzN4PD;hQi=>
L1210 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlLnNkBl[Xm| M2jSPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOgZYZ1\XJiMjDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlkh|ryPLh?= NVnJbXRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
MCF7 NGTaTI5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoPaN{Bl[Xm| NYX3[G1mSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlUh|ryPLh?= MoCwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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WI38 M4j5[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MofYN{Bl[Xm| MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXTVM5KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNEDPxE1w NYfibFNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
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HCT116 NHLNZ4pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYW3NkBpenN? NX\GdoZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIvPiEQvF2u M2ruOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{SzPFY{Lz5zOUe0N|g3OzxxYU6=
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HepG2 NYG1fJFLS3m2b4TvfIlkcXS7IHHzd4F6 MkfkO|IhcHK| NUTte3U3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN{LkKyJO69VS5? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{e0OUc,OjJ4OEe3OFU9N2F-
NCI-H460 NHnweZJEgXSxdH;4bYNqfHliYYPzZZk> Ml3yO|IhcHK| NVTyb4lZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOEDPxE1w M2H0SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
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HepG2 MmHTR5l1d3SxeHnjbZR6KGG|c3H5 Mni4O|IhcHK| NXPO[otFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwODFOwG0v Mln6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
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MCF7 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NHnBdnk4OiCqcoO= NV3WNFNjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTJwNTFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
KB M{nFO2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1\xcVczKGi{cx?= NITJTlREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPE4zQCEQvF2u NIPqSYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
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MGC803 NWHZWmNZS3m2b4TvfIlkcXS7IHHzd4F6 NGLudoY4OiCqcoO= MkXFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQC53IN88UU4> Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
MCF7 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWS3NkBpenN? MmfYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bu\XSqb3SsJGlEPTBiPTC0Mlch|ryPLh?= NGT2O4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
HT-29 Mn;3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFXTUpk4OiCqcoO= NX[1emNuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdibXX0bI9lNCCLQ{WwJF0hPy5|IN88UU4> NFmyRnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
MDA-MB-231 NHrWUGJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWi0OIZKPzJiaILz MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIH3leIhw\CxiSVO1NEA:KDlwNjFOwG0v NITmNWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
HT1080 MmG5R5l1d3SxeHnjbZR6KGG|c3H5 NFTmfGhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xPiEQvF2u M1;hRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
A375-S2 NETKeoJEgXSxdH;4bYNqfHliYYPzZZk> M1\tWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE{PzVvU{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPU46OiEQvF2u NXLXSmU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
HeLa MX;DfZRwfG:6aXPpeJkh[XO|YYm= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkO2JO69VS5? NWL6TnRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
HepG2 M1mwcWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD60OUDPxE1w NVnyZVQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
BGC823 NWXL[GhmS3m2b4TvfIlkcXS7IHHzd4F6 MofCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmdEQDJ|IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlY2KM7:TT6= NY\QWnM6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
Hep2 M3zBdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIi4OJZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlU5KM7:TT6= NEnO[JE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MCF7 M3XlTGN6fG:2b4jpZ4l1gSCjc4PhfS=> M17KZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOVgh|ryPLh?= M4WwXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
A549 MXTDfZRwfG:6aXPpeJkh[XO|YYm= NF3nV2tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOxMlUzKM7:TT6= M3W2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
MDA231 M2Tuc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEzOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{GuOVch|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
PC3 MVTDfZRwfG:6aXPpeJkh[XO|YYm= NGHoPIVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuO|Uh|ryPLh?= NFLD[ow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
PC3M M1uwfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVW0PEBpenN? MmHNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{VSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlIvPjNizszNMi=> NXe0T2dmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFk2PThpPkKyPFA6PTV6PD;hQi=>
A549 MVTDfZRwfG:6aXPpeJkh[XO|YYm= MXy0PEBpenN? NUi3[W9IS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzVwNEGg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
MKN45 NFXFc49EgXSxdH;4bYNqfHliYYPzZZk> M1r2dFQ5KGi{cx?= NVr3RnNKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRzLkezJO69VS5? NXXNNZg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFk2PThpPkKyPFA6PTV6PD;hQi=>
HepG2 NUG0c3JbS3m2b4TvfIlkcXS7IHHzd4F6 NXLUZ3c{PDhiaILz NF3uWVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDZwOEOg{txONg>? NITQfnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwPVU2QCd-MkK4NFk2PTh:L3G+
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A549 Mmr1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Ml;aOFghcHK| NYHYeGc2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNk45KM7:TT6= MoDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NEC0PVMoRjJ{OESwOFk{RC:jPh?=
MCF7 MnTZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3zGWFQ5KGi{cx?= MojYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6yJO69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh2MES5N{c,OjJ6NEC0PVM9N2F-
IOSE-144 M3nJU2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEjydnk1QCCqcoO= MnnTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCLT2PFMVE1PCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUvPiEQvF2u NVXQNW9tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
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MNK45 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MlrTOFghcHK| MnjQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUW5MPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzKM7:TT6= MnnKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMEK5NlQoRjJ|MECyPVI1RC:jPh?=
HepG2 NV:0SFFySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV20PEBpenN? NXe1SHVGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFEvOyEQvF2u NHPQXnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
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2008 NUKzPZh1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH7NSpFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckAzODB6IHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KGG|c3H5MEBKSzVyIE2gOE4zKM7:TT6= Mn3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyN{W0NVQoRjJ|MEe1OFE1RC:jPh?=
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leukemia NUC0O2lMS3m2b4TvfIlkcXS7IHHzd4F6 MXK0PEBpenN? M4nmcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzwbI9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFE2NjFizszNMi=> NELGZYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3OFg6QSd-MkO0O|Q5QTl:L3G+
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renal cancer MlHiR5l1d3SxeHnjbZR6KGG|c3H5 NU\ySmNjPDhiaILz NUHuPJVmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyyaH;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IES1MlYh|ryPLh?= M1LlTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEe0PFk6Lz5{M{S3OFg6QTxxYU6=
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MCF7 M1\rO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXe0PEBpenN? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNU42KM7:TT6= NIr6UXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
K562 Moj4R5l1d3SxeHnjbZR6KGG|c3H5 NFjtV481QCCqcoO= MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyN{42PSEQvF2u M{flS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUW4NlM5Lz5{M{W1PFI{QDxxYU6=
U937 NYjoV5p7S3m2b4TvfIlkcXS7IHHzd4F6 NXG0OXlZPDhiaILz MoXRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvQTNizszNMi=> NX\HWHJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
HCT116 NH\MU5dEgXSxdH;4bYNqfHliYYPzZZk> MVu0PEBpenN? NFfvSJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5Lke2JO69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
HT1080 M1exU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUfKb5VDPDhiaILz M1HMUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVOTB6MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzVwNkKg{txONg>? NIHYWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HepG2 MlrxR5l1d3SxeHnjbZR6KGG|c3H5 NF7Q[HU1QCCqcoO= NFHJcmxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwM{Sg{txONg>? NHfQTYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
A549 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MlLKOFghcHK| Mk[4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFQvODVizszNMi=> NVLDRWpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
EC9706 MnX6R5l1d3SxeHnjbZR6KGG|c3H5 MXK3NkBpenN? MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFR|k4ODZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOzJizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
MGC803 M4PRUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUO3NkBpenN? NHzD[25EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwMUSg{txONg>? NI[5N4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFE6Oyd-MkO2OFQyQTN:L3G+
MCF7 MYjDfZRwfG:6aXPpeJkh[XO|YYm= MoP6O|IhcHK| M3LFNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvOzNizszNMi=> M4K0cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NVk{Lz5{M{[0OFE6OzxxYU6=
SMMC7721 M1\VRmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYfLeFNkPzJiaILz MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwN{Gg{txONg>? NWTsc4Z{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQyQTNpPkKzOlQ1OTl|PD;hQi=>
HCT116 NFrscWFEgXSxdH;4bYNqfHliYYPzZZk> M4XEOlQ5KGi{cx?= M1zSbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IESuOVIh|ryPLh?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxOUc,OjN4NESyNVU9N2F-
HT-29 NITVVXREgXSxdH;4bYNqfHliYYPzZZk> NGLhcFI1QCCqcoO= MnPvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVAhRSB4LkO1JO69VS5? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxOUc,OjN4NESyNVU9N2F-
A549 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYG3NkBpenN? MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwNUKg{txONg>? NHG0e2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2OVExPid-MkO2OlUyODZ:L3G+
HCT116 M1fyS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWW3NkBpenN? NGqwe5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU42OyEQvF2u MmXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
HT-29 Mn;mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Ml;XO|IhcHK| MoDKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOUDPxE1w NF7tOpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2OVExPid-MkO2OlUyODZ:L3G+
MCF7 NGX2VWxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFLQVZE4OiCqcoO= M2\1VGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{KuNVgh|ryPLh?= MkTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
HeLa MnfIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MX23NkBpenN? NIrvdmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESzMlcyKM7:TT6= NVjsRVZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OlUyODZpPkKzOlY2OTB4PD;hQi=>
colon cancer M4HyWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYjVXlQ{PDhiaILz MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCjbnHsfZNqeyxiR1m1NEA:KDhwNDFOwG0v MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6M{W5Nkc,OjN4OEO1PVI9N2F-
leukemia NIDSUWhEgXSxdH;4bYNqfHliYYPzZZk> M1[3NlQ5KGi{cx?= MlXaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whT0l3MDC9JFE2NjFizszNMi=> NUDRcIh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
prostate cancer MXnDfZRwfG:6aXPpeJkh[XO|YYm= M{[xclQ5KGi{cx?= Ml;FR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62ZYKgZY5idHm|aYOsJGdKPTBiPTCyNk44KM7:TT6= M{e5dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkizOVkzLz5{M{[4N|U6OjxxYU6=
renal cancer MXnDfZRwfG:6aXPpeJkh[XO|YYm= MWe0PEBpenN? NYf3OWd2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62ZYKgZY5idHm|aYOsJGdKPTBiPTC0OU43KM7:TT6= M3z3flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkizOVkzLz5{M{[4N|U6OjxxYU6=
SH-SY5Y NFLBdWFEgXSxdH;4bYNqfHliYYPzZZk> NWn3Woh1PzJiaILz M{O4emN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNJNVO\NWmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOUeg{txONg>? NX7xTmRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFU2PzFpPkKzOlg2PTdzPD;hQi=>
HCT116 MnPGR5l1d3SxeHnjbZR6KGG|c3H5 Mn\HO|IhcHK| NU\QfWN{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkK0JO69VS5? NELxfXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU4OSd-MkO2PFU2PzF:L3G+
A549 NGq1XoJEgXSxdH;4bYNqfHliYYPzZZk> M{fzfFczKGi{cx?= MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4MlcyKM7:TT6= Mn7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
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MCF7 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M2TJfVczKGi{cx?= M1v1XWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjF2IN88UU4> Mle3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
HepG2 M4PjfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3;4TFczKGi{cx?= M1SxRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC57NjFOwG0v M4[0RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nki1OVcyLz5{M{[4OVU4OTxxYU6=
PC3 M4HLOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3nYZVczKGi{cx?= NEPSbndCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDlfJBz\XO|aX7nJHNMWDJiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5LkC3JO69VS5? MlviQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{WyPFEoRjJ|N{O1NlgyRC:jPh?=
PC3 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlvOO|IhcHK| NXj3UXllSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[ZhxemW|c3nu[{BRS0SQQTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{GuOFQh|ryPLh?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd|NUK4NUc,OjN5M{WyPFE9N2F-
COLO320DM MlP1R5l1d3SxeHnjbZR6KGG|c3H5 NXTublV[PDhiaILz MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOzJyRF2gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJizszNMi=> MonkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUKzOVIoRjJ|N{myN|UzRC:jPh?=
HeLa MnvCR5l1d3SxeHnjbZR6KGG|c3H5 M4i1NlczKGi{cx?= MnfRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{41KM7:TT6= M2TpfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{myO|Y{Lz5{M{e5Nlc3OzxxYU6=
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A549 MXzDfZRwfG:6aXPpeJkh[XO|YYm= M{TsXVQ5KGi{cx?= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzOE4{OyEQvF2u MmPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OEizOVcoRjJ|OUi4N|U4RC:jPh?=
NCI-H460 NVL3c4RLS3m2b4TvfIlkcXS7IHHzd4F6 MVO0PEBpenN? NITTR2VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNESuNFQh|ryPLh?= NWrGWlFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
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colon cancer NXrCWZg6S3m2b4TvfIlkcXS7IHHzd4F6 MlLLOFghcHK| NWX5dFFxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[2:ub36gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA5NjRizszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7NEOyPEc,OjN7OUSzNlg9N2F-
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HCT116 NGrwZnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXYOFghcHK| NETBbZRIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlcvPzZizszNMi=> NYLxV45lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
HT1080 Ml[4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVK0PEBpenN? Ml\wS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKVEGwPFAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1MlYzKM7:TT6= NF61OJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1Pid-MkO5PVkxPDZ:L3G+
HepG2 NW\5Onl3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvlXok1PDhiaILz M2nsfWdzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESwMlM1KM7:TT6= NGDO[Zk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1Pid-MkO5PVkxPDZ:L3G+
A549 NFXZNYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\2dnJOPDhiaILz NFrWSVFIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES0MlA2KM7:TT6= NXr2cVZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
QSG7701 NX;DSXBFS3m2b4TvfIlkcXS7IHHzd4F6 NEfscGw1QCCqcoO= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRV2c4PzBzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwNjFOwG0v M4exd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGzOFE2Lz5{NECxN|QyPTxxYU6=
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QGY7703 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MnyzOFghcHK| MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRS3k4PzB|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF3Lk[2JO69VS5? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzM{SxOUc,OjRyMUO0NVU9N2F-
Hep NH:yZlZEgXSxdH;4bYNqfHliYYPzZZk> MnrBOFghcHK| NIDD[YJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u NHPYV209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC1OlE1Pid-MkSwOVYyPDZ:L3G+
IMR32 MmXNR5l1d3SxeHnjbZR6KGG|c3H5 Mo\LOFghcHK| M3:2NWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGlOWjN{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAyNjNizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB3NkG0Okc,OjRyNU[xOFY9N2F-
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DU145 MkX2R5l1d3SxeHnjbZR6KGG|c3H5 NVG3NZB2S3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMtKEmFNUCgQUA{NjRizszNMi=> NFXyVZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG5OVQ3Pid-MkSxPVU1PjZ:L3G+
NCI-H460 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NH3iUJZEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyxiSVO1NEA:KDhwNTFOwG0v NYfY[2ZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPVU1PjZpPkK0NVk2PDZ4PD;hQi=>
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MGC803 Mn:5R5l1d3SxeHnjbZR6KGG|c3H5 NX\NTGdGPzJiaILz NWnFcXp4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6zNkDPxE1w NULxWphLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVExOjFpPkK0NlEyODJzPD;hQi=>
HepG2 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NUP5WlNvPzJiaILz M4nyPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQS52NTFOwG0v NGnzcmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKxNVAzOSd-MkSyNVExOjF:L3G+
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SW1116 MYjDfZRwfG:6aXPpeJkh[XO|YYm= MVq0PEBpenN? Ml;OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3cyOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjJ4IN88UU4> NYXxfHVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFY4PjFpPkK0Nlg3PzZzPD;hQi=>
HepG2 MVLDfZRwfG:6aXPpeJkh[XO|YYm= MUi0PEBpenN? MoT0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvPDNizszNMi=> NELKO3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4Olc3OSd-MkSyPFY4PjF:L3G+
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MCF7 MnHqR5l1d3SxeHnjbZR6KGG|c3H5 NIXTbVU1QCCqcoO= NFLxOYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6Njd7IN88UU4> NVfibHBvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFY4PjFpPkK0Nlg3PzZzPD;hQi=>
MCF7 NVvEfohLS3m2b4TvfIlkcXS7IHHzd4F6 M3LRTVQ5KGi{cx?= NHfQboREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjVizszNMi=> NWDHS49ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|I1QTdpPkK0N|MzPDl5PD;hQi=>
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ME180 M1zwVGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWTRW2hiPDhiaILz MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSVE5OCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE46KM7:TT6= NXHLUVl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|I1QTdpPkK0N|MzPDl5PD;hQi=>
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HCT116 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MVu0PEBpenN? M{fX[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS55ODFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN5OEKxO{c,OjR|N{iyNVc9N2F-
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SPCA2 Mnr6R5l1d3SxeHnjbZR6KGG|c3H5 MmrHOFghcHK| MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTVGNCOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFIvOiEQvF2u NHS4V|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFIyPyd-MkSzO|gzOTd:L3G+
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leukemia NXzqbmpLS3m2b4TvfIlkcXS7IHHzd4F6 NFHKbG8yOCC3TR?= NVvndpR{PDhiaILz MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjdDCxNEB2VSCjZoTldkA1QCCqcoOsJGdKPTBiPTCxOU4yKM7:TT6= M2fIdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NE[5NVEzLz5{NES2PVEyOjxxYU6=
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EAC MUnDfZRwfG:6aXPpeJkh[XO|YYm= MWm0PEBpenN? M2CwUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGVCSyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvOyEQvF2u M{PkWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUO0OVM4Lz5{NEWzOFU{PzxxYU6=
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HCT116 M4C5NGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYXEflBpPDhiaILz M3LENmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwNEOg{txONg>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV4NUmwOUc,OjR3NkW5NFU9N2F-
SKOV3 NUm2e2dvS3m2b4TvfIlkcXS7IHHzd4F6 Mnj4OFghcHK| MnLmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjR|IN88UU4> M3TZS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
Bel7404 MYXDfZRwfG:6aXPpeJkh[XO|YYm= M2nyeFQ5KGi{cx?= Mn7JR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoVtPzRyNDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwODFOwG0v NGnKXYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW2OVkxPSd-MkS1OlU6ODV:L3G+
HepG2 MkDqR5l1d3SxeHnjbZR6KGG|c3H5 Mn7UOFghcHK| MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlYvQThizszNMi=> NIPhUG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW2OVkxPSd-MkS1OlU6ODV:L3G+
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H3347 NUPIVWN[S3m2b4TvfIlkcXS7IHHzd4F6 MlKzO|IhcHK| NX7QcVZjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDN|NEegZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFHsZY1ieiCEbIXlJIF{e2G7LDDJR|UxKD1iMUGuOlQh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6M{O1OUc,OjR3OEOzOVU9N2F-
HT-29 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NWPaVFhXPzJiaILz M3v3OGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCDbHHtZZIhSmy3ZTDhd5NigSxiSVO1NEA:KDJ2Lki3JO69VS5? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6M{O1OUc,OjR3OEOzOVU9N2F-
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SGC7901 NWroXGlWS3m2b4TvfIlkcXS7IHHzd4F6 NXvDOFRuPDhiaILz NXrJUY5OS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj61OkDPxE1w NEPQfW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUW1OFkzOid-MkW1OVQ6OjJ:L3G+
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LoVo MoHqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2LLXFczKGi{cx?= NH\QUm9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzvWo8h[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUCgQUA1NjZ7IN88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
doxorubicin-resistant LoVo/DX NYqy[Jh6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NI\rO4M4OiCqcoO= MkTIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgUI9Xdy:GWDDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJI1mfGixZDygTWM2OCB;IE[g{txONg>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
SW707 M{\ZWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NU\o[IxTPzJiaILz NHLiUFlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXO|A4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJibXX0bI9lNCCLQ{WwJF0hOjBwNE[g{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
vincristine-resistant HL60/Vinc NYXsdY1oSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3PrVlczKGi{cx?= M3HHS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5idnnuZ5Jqe3SrbnWtdoV{cXO2YX70JGhNPjBxVnnuZ{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlEvOTVizszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
HL60 NFrnbJRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1f3dFczKGi{cx?= MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKyMlU1KM7:TT6= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
HT-29 M2PGeWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NITRdW44OiCqcoO= M4O5V2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUCgQUAzPS5yODFOwG0v M4LYblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
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EC109 M1XZe2FvfGmlYX7j[ZIh[XO|YYm= MUW3NkBpenN? M13kcmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLk[xJO69VS5? MmXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUW3NVgoRjJ3NkW1O|E5RC:jPh?=
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HCT8 NHLmblRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3S0dFczKGi{cx?= MnrORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDC1MWZWKHKnc3nzeIFvfCCqdX3hckBJS1R6IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Pi54M{ig{txONg>? MkP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{WxOFQoRjJ3Nke1NVQ1RC:jPh?=
MGC803 M3G5SGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{\ncVczKGi{cx?= NWTCVVdMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD63NkDPxE1w NVHxUmRIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NFcxOTJpPkK1O|A4ODF{PD;hQi=>
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SMMC7721 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MkS1O|IhcHK| NE[2TZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCuOEDPxE1w NITsdXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewO|AyOid-MkW3NFcxOTJ:L3G+
SW1573 MlrURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlzwOFghcHK| NV7GdVFZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|E2PzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSB2LkOg{txONg>? MkDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUK1NlUoRjJ3N{WyOVI2RC:jPh?=
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DU145 M4fGe2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXq0PEBpenN? NFOxT4xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC2MlA4OiEQvF2u M4XxT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{CxOVU5Lz5{NkOwNVU2QDxxYU6=
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MCF7 M3[5emN6fG:2b4jpZ4l1gSCjc4PhfS=> MVK0PEBpenN? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU4{QSEQvF2u NVGwfW1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zOlM5PjlpPkK2N|Y{QDZ7PD;hQi=>
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MCF7 MnXvR5l1d3SxeHnjbZR6KGG|c3H5 NYK0T3o{PDhiaILz M2LVOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIh|ryPLh?= MnnPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NUSzO|UoRjJ4OEW0N|c2RC:jPh?=
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Hep3B M4i2W2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlH2OFghcHK| NYLDXplTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkWzJO69VS5? M1vqXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEizNVQ5Lz5{Nki4N|E1QDxxYU6=
A549 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MUG0PEBpenN? NF;uc5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{PC5{NzFOwG0v NGDVc409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki4N|E1QCd-Mk[4PFMyPDh:L3G+
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HepG2 NVTEeWprS3m2b4TvfIlkcXS7IHHzd4F6 M1WwO|Q5KGi{cx?= M3PWZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1QS55MjFOwG0v NGTsfXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki4N|E1QCd-Mk[4PFMyPDh:L3G+
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HL60 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYLOSJVJPzJiaILz M1TCUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkeuOFMh|ryPLh?= MmjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyNlMoRjJ4OUKyNlI{RC:jPh?=
HCT116 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MojpO|IhcHK| Mn\xRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO4MlMh|ryPLh?= M2rDdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKyNlI{Lz5{NkmyNlIzOzxxYU6=
HepG2 NIjLSHlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWHwNGlOPzJiaILz NXjmNHlHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFkvODJizszNMi=> MnrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyNlMoRjJ4OUKyNlI{RC:jPh?=
HT-29 NUTsWZFQSW62aXPhcoNmeiCjc4PhfS=> M4DlfFczKGi{cx?= NIfzSXRCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5|IN88UU4> MoXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyN|MoRjJ4OUKyNlM{RC:jPh?=
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HCT116 NYrsUmx4SW62aXPhcoNmeiCjc4PhfS=> M3LmZlczKGi{cx?= NVHUNXB2SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nz64JO69VS5? MmnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyN|MoRjJ4OUKyNlM{RC:jPh?=
RKO MUjBcpRq[2GwY3XyJIF{e2G7 Ml3GOFghcHK| NIDUTHpCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVmtQKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIgh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQyNjFizszNMi=> M4DIXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKyNlM{Lz5{NkmyNlI{OzxxYU6=
KB M1nSN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWO3NkBpenN? NXfDboM{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvQDRizszNMi=> NX72WGJjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
HeLa MULDfZRwfG:6aXPpeJkh[XO|YYm= M3P6VVczKGi{cx?= NVrhTm0{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi5{MzFOwG0v NUXEemM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
MCF7 MmjmR5l1d3SxeHnjbZR6KGG|c3H5 MUW3NkBpenN? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IE[uOVMh|ryPLh?= MmXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
HepG2 M33oWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXu3NkBpenN? NILUUXVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi54IN88UU4> NISwRo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
HDF NGDRSnFEgXSxdH;4bYNqfHliYYPzZZk> NF7GRlk4OiCqcoO= M33FTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiGRjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPy5yMjFOwG0v MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
143B Mn2yR5l1d3SxeHnjbZR6KGG|c3H5 NGP6dGI4OiCqcoO= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCxOFNDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxN{4xOSEQvF2u MkntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
thymidine kinase deficient 143B MXjDfZRwfG:6aXPpeJkh[XO|YYm= NIPTOYI4OiCqcoO= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDCxOFNDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxOk4{OSEQvF2u M2HyOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
U87MG MVvDfZRwfG:6aXPpeJkh[XO|YYm= NVPkNpoyPzJiaILz NEfDNFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDePRzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IGqyJINwfWy2ZYKgZ492dnSncjDt[ZRpd2RuIFnDOVAhRSBzOD6yOUDPxE1w MkPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOEG3OFIoRjJ5MEixO|QzRC:jPh?=
PC3 NIniXWRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3LRTlQ5KGi{cx?= NVHXdW9FSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuO|Yh|ryPLh?= NYq1eIxXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
HT-29 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NV[2epNrPDhiaILz MmS3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj64JO69VS5? NGXPeZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C5NlQyOyd-MkewPVI1OTN:L3G+
U87MG NIjaVmFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEPCSYw1QCCqcoO= M4Dr[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVUi3UWch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuOlUh|ryPLh?= NX2xUHVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
A549 M3LFSmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGfCN201QCCqcoO= NUTiRpl4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlk5KM7:TT6= M4T2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
HaCaT NWPpZ|lPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYK0PEBpenN? NVrHc2ZySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIZWNiXCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvOTVizszNMi=> NVrCc5VwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
MGC803 M2Dqb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M13tdVczKGi{cx?= NGTLcHBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlI2KM7:TT6= NX\Vc4lERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNFUxOjhpPkK3NVA2ODJ6PD;hQi=>
EC109 NEHNVFdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXHjNGxvPzJiaILz MnTsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ{GwPUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkG3JO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyNUCyPEc,OjdzMEWwNlg9N2F-
SH-SY5Y MoG1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mk\5O|IhcHK| M{HRZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlI3KM7:TT6= NVv1TIkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNFUxOjhpPkK3NVA2ODJ6PD;hQi=>
U87 NGfJeoxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV3TeWR5PzJiaILz NHXaZmlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW4O{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3Lk[xJO69VS5? MmXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
MCF7 NHOzVoFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmT6O|IhcHK| NUS1VFNUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuOlEh|ryPLh?= MnLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
MDA-MB-231 NHq5NHRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEPaRZU1QCCqcoO= M1fidmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwNjFOwG0v M1HyS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
MCF7 M2qwbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGXmNFc1QCCqcoO= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyLkSxJO69VS5? NYrWPFhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyQDBpPkK3NVI5OThyPD;hQi=>
A549 M3HBcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MYe0PEBpenN? NF;4[pdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1MlQyKM7:TT6= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG4NEc,OjdzMkixPFA9N2F-
HepG2 MlvzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUjYTmdbPDhiaILz MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Nj64N{DPxE1w M{n5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
MCF7 NUHUeGZvS3m2b4TvfIlkcXS7IHHzd4F6 NF:yPJk1QCCqcoO= NGrOWoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOy53IN88UU4> NFPUNG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
Bcap37 NEjCcolEgXSxdH;4bYNqfHliYYPzZZk> NVXF[IJ6PDhiaILz NILCVm1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD[2GyM{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkS3JO69VS5? MmeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
Hep3B M{\Be2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYq0PEBpenN? M{nJXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy53MzFOwG0v M3;yd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
A549 NUD3c4piS3m2b4TvfIlkcXS7IHHzd4F6 NW\IeGVMPDhiaILz NHv5PGVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOS53ODFOwG0v NHK4UHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
U251 NULic45ZS3m2b4TvfIlkcXS7IHHzd4F6 NYfWZ4c2PDhiaILz NXHhfnhES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwNkmg{txONg>? Mk\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
HepG2 M3ziSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVO0PEBpenN? NYS4OYh5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ3LkG3JO69VS5? MnP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
LNCAP NI\0SmFEgXSxdH;4bYNqfHliYYPzZZk> NILSPGczPCCqcoO= NWfHdlNYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMkSgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> NHLUU|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G1Olc4OCd-MkexOVY4PzB:L3G+
PC3 M{[4Z2N6fG:2b4jpZ4l1gSCjc4PhfS=> NH7HZXkzPCCqcoO= NWnOUHZiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDJ2IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBKSzVyIE2gNE4xOyEQvF2u MmDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNU[3O|AoRjJ5MUW2O|cxRC:jPh?=
Bcap37 M175fWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3rrbVQ5KGi{cx?= M4D1WGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6xPEDPxE1w NE\2Nm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4PVY4Pid-MkexPFk3PzZ:L3G+
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SGC7901 M{\uO2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFvnNHk4OiCqcoO= M2[wdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLkmg{txONg>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV|N{myOEc,Ojd3M{e5NlQ9N2F-
MDA-MB-435S MXTDfZRwfG:6aXPpeJkh[XO|YYm= MonQO|IhcHK| MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuNkDPxE1w NXvpNZNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1N|c6OjRpPkK3OVM4QTJ2PD;hQi=>
PC3 NXP5TG97S3m2b4TvfIlkcXS7IHHzd4F6 NY\ZUZFsPzJiaILz MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESyMlUh|ryPLh?= NV3uUVY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1N|c6OjRpPkK3OVM4QTJ2PD;hQi=>
colon cancer cell NGr5NGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmf4OFghcHK| MV;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEiuOEDPxE1w NWLBdYRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OVQ1PDRpPkK3OVU1PDR2PD;hQi=>
leukemia cell MmThS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVjaWmgzPDhiaILz NXXrXolsT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEG1MlEh|ryPLh?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV3NES0OEc,Ojd3NUS0OFQ9N2F-
prostate cancer cell M3LYSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\hUHE1QCCqcoO= M3:5fGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJJBzd3O2YYTlJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOjJwNzFOwG0v NF7aNpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W1OFQ1PCd-Mke1OVQ1PDR:L3G+
renal cancer cell NWXYW4F2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2nmd|Q5KGi{cx?= Mlv1S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTC0OU43KM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV3NES0OEc,Ojd3NUS0OFQ9N2F-
DU145 MXLDfZRwfG:6aXPpeJkh[XO|YYm= MYq0PEBpenN? NVPOfVN1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOk4yKM7:TT6= NH2xdnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W2NVcyQCd-Mke1OlE4OTh:L3G+
HeLa MVzDfZRwfG:6aXPpeJkh[XO|YYm= NYDvOIo5PDhiaILz NIH0OnJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuNkDPxE1w NVSwSnNPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
IOSE-144 MnyzR5l1d3SxeHnjbZR6KGG|c3H5 M1n1flQ5KGi{cx?= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDJU3NGNTF2NDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2MlEh|ryPLh?= NWnsVHB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
HepG2 NYDBXphKS3m2b4TvfIlkcXS7IHHzd4F6 M4nnZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT6zJO69VS5? NIj2bVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W2NVcyQSd-Mke1OlE4OTl:L3G+
DU145 MWHDfZRwfG:6aXPpeJkh[XO|YYm= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNjFOwG0v MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV4MUexPUc,Ojd3NkG3NVk9N2F-
MDA-MB-231 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NXf1SG9{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v M3LITlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
HeLa MVHDfZRwfG:6aXPpeJkh[XO|YYm= MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS57IN88UU4> NXGxO2Q4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OTlpPkK3OVYyPzF7PD;hQi=>
SW780 NXP0OGYzS3m2b4TvfIlkcXS7IHHzd4F6 NELXcHo4OiCqcoO= NUDIb4N2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d5OECgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYmsJGlEPTBiPTC2Mlk6KM7:TT6= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV7N{SxNUc,Ojd3OUe0NVE9N2F-
MGC803 Mo\mR5l1d3SxeHnjbZR6KGG|c3H5 MXS3NkBpenN? NWTV[VI2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gNVAvPjRizszNMi=> NEHRZpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W5O|QyOSd-Mke1PVc1OTF:L3G+
HL-7702 MVLDfZRwfG:6aXPpeJkh[XO|YYm= NVfFRolFPzJiaILz MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUE04PzB{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUKuPFUh|ryPLh?= MlXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
MCF7 NVrSO|hnS3m2b4TvfIlkcXS7IHHzd4F6 MYK3NkBpenN? M37QXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSBzMz6xPUDPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV7N{SxNUc,Ojd3OUe0NVE9N2F-
GES-1 M1;KZmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2Ll[FczKGi{cx?= MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHSXMuOSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDF|Lke1JO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV7N{SxNUc,Ojd3OUe0NVE9N2F-
TE1 NX;kXo1[S3m2b4TvfIlkcXS7IHHzd4F6 MXe3NkBpenN? MnnhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGUyKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hOTdwM{Kg{txONg>? Mlf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
A549 M3m2RmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFO3PZk1QCCqcoO= MoXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNE41PyEQvF2u M3LrblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkG0OFA5Lz5{N{[xOFQxQDxxYU6=
MDA-MB-231 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NIG5XFQ1QCCqcoO= MljPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|NT65PEDPxE1w NYfYU4UzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
DU145 NXnRfHF[S3m2b4TvfIlkcXS7IHHzd4F6 NWiwbIVMPDhiaILz MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NE42QCEQvF2u MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZzNESwPEc,Ojd4MUS0NFg9N2F-
PC3 MnHiR5l1d3SxeHnjbZR6KGG|c3H5 NVHCdGVvPDhiaILz NH7pXlVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFUvOzJizszNMi=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZzNESwPEc,Ojd4MUS0NFg9N2F-
MCF7 MlG0R5l1d3SxeHnjbZR6KGG|c3H5 M4\V[lQ5KGi{cx?= MkXpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwJF0hPC53IN88UU4> NUnKdG5kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQDRpPkK3Olg5OTh2PD;hQi=>
HepG2 NILzcWhHfW6ldHnvckBie3OjeR?= NWnlSodsPDhiaILz M2f1NGhmeGG2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IEeg{txONg>? M{izU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVg1Lz5{N{[4PFE5PDxxYU6=
U87 NE\xcVhHfW6ldHnvckBie3OjeR?= NYD5UplUPDhiaILz MUPO[ZVzd3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEeLNUCgQUAyOyEQvF2u NFPCTmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE5PCd-Mke2PFgyQDR:L3G+
HCT116 NGLFeI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LSZlczKGi{cx?= M2i2S2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOi53IN88UU4> NHTDZXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{ewOFgyOSd-Mke3NFQ5OTF:L3G+
HeLa NVntXnFNS3m2b4TvfIlkcXS7IHHzd4F6 MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS54IN88UU4> NF3Vc2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{eyNFI6Pid-Mke3NlAzQTZ:L3G+
PC3 NEjw[oVEgXSxdH;4bYNqfHliYYPzZZk> NVnzTINuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT64JO69VS5? Mn7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkCyPVYoRjJ5N{KwNlk3RC:jPh?=
HepG2 M3PkXGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NWTBS5VPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NlAzQTZpPkK3O|IxOjl4PD;hQi=>
MDA-MB-231 MYjDfZRwfG:6aXPpeJkh[XO|YYm= MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNU46KM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd{MEK5Okc,Ojd5MkCyPVY9N2F-
L1210 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoTDOFghcHK| M2fabWFvfGlvcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFyxNlExKGOnbHzzJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOC5|MzFOwG0v MnfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
HeLa MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXK0JIRigXN? MXzBcpRqNXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IH3lZZN2emWmIHHmeIVzKDRiZHH5d{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE42PCEQvF2u NHzvZpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
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MGC803 MWPDfZRwfG:6aXPpeJkh[XO|YYm= MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvOTRizszNMi=> M2r1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{[5NFM1Lz5{N{e2PVA{PDxxYU6=
A549 Mn\wR5l1d3SxeHnjbZR6KGG|c3H5 M3LyPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvQTVizszNMi=> NHTwWlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVA{PCd-Mke3OlkxOzR:L3G+
EC109 M3jjUGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSWMyODliY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUvQTlizszNMi=> NXLtZWx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OlkxOzRpPkK3O|Y6ODN2PD;hQi=>
MGC803 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1Hjb|czKGi{cx?= M4HmXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlM2KM7:TT6= M2WyUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{exOVk6Lz5{N{e3NVU6QTxxYU6=
MCF7 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3vLfFczKGi{cx?= MoPoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkK1JO69VS5? NWfybYdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|E2QTlpPkK3O|cyPTl7PD;hQi=>
EC109 NF33SppCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXXmZVE6PzJiaILz NYn6UJM4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPTlizszNMi=> Mmj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{G1PVkoRjJ5N{exOVk6RC:jPh?=
HUCCA NX;5TGNuS3m2b4TvfIlkcXS7IHHzd4F6 M{nYfVI1KGi{cx?= NUK5eVFDS3m2b4TvfIlkcXS7IHHnZYlve3RiSGXDR2Eh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjRizszNMi=> NEfCO2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyOVc3Oyd-Mke4NlU4PjN:L3G+
QBC939 NHzUNm5EgXSxdH;4bYNqfHliYYPzZZk> NVP2b3FROjRiaILz NGHlO2xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBSSkN7M{mgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlEh|ryPLh?= Ml3HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MkW3OlMoRjJ5OEK1O|Y{RC:jPh?=
SW620 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2nJTFczKGi{cx?= NV7sZ5ZnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xQCEQvF2u NHX2OGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
CFPAC-1 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHHnUo84OiCqcoO= M2TWOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1\QRWMuOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yPCEQvF2u M4HZUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
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A549 NEnBWZpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXO3NkBpenN? MmHpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Lkig{txONg>? NUfwenRTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
HeLa NY[xbYZTSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXT2XVRsPzJiaILz NF\2cGZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuPFEh|ryPLh?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh5NUe3PUc,Ojd6N{W3O|k9N2F-
HepG2 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWO3NkBpenN? NHnVfpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4Mlkh|ryPLh?= NY\0Z4xbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
Hep3B M1;PRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYLDRYFoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlM3KM7:TT6= M1WzdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUGzNVc6Lz5{N{mxN|E4QTxxYU6=
A549 NIPhV|REgXSxdH;4bYNqfHliYYPzZZk> NGq2VFFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uOlMh|ryPLh?= NHrVR4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mxN|E4QSd-Mke5NVMyPzl:L3G+
WISH NH;SUmxEgXSxdH;4bYNqfHliYYPzZZk> MkmwNlQhcHK| NFOxNZVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUVOKIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6xJO69VS5? NFrJb3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1NVQ5Pyd-Mke5OVE1QDd:L3G+
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A549 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVK3NkBpenN? MlzGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkG2JO69VS5? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl6N{S4OUc,Ojd7OEe0PFU9N2F-
MDA-MB-231 NVTWe4xJSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGnzNHU4OiCqcoO= NU\lO3ZxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3IN88UU4> MlXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEe0PFUoRjJ5OUi3OFg2RC:jPh?=
HepG2 NUm4eXhuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkHRO|IhcHK| NWOxeI5VSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOUDPxE1w M{LKNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUi3OFg2Lz5{N{m4O|Q5PTxxYU6=
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Hep3B NFzmTZREgXSxdH;4bYNqfHliYYPzZZk> Mm[2OFghcHK| MlzzR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwN2Ih[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjV|IN88UU4> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7M{WxOkc,Ojd7OUO1NVY9N2F-
HepG2 Mm\ZR5l1d3SxeHnjbZR6KGG|c3H5 MlXrOFghcHK| NH\nTFJEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzJwNjFOwG0v NGnud3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5N|UyPid-Mke5PVM2OTZ:L3G+
HepG2 NULsN5ZTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXLW3pnOjRiaILz MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvQDdizszNMi=> M4TkVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEGxNlIxLz5{OECxNVIzODxxYU6=
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HCT15 MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUK2U|hFOjRiaILz MonzS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ2NjBzIN88UU4> MmLzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyMUGyNlAoRjJ6MEGxNlIxRC:jPh?=
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MCF7 NY\1ZWtnS3m2b4TvfIlkcXS7IHHzd4F6 MnvTOFghcHK| NGXQRVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDR{Lke4JO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
Bcap37 M2LGd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NE\JPXM1QCCqcoO= M{f6VGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCClb3zvdolu\XS{aXOgZZN{[XluIFnDOVAhRSB2Nz6xJO69VS5? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
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MGC803 M{ezXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2\2XVQ5KGi{cx?= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6yNUDPxE1w M375NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N|I6Lz5{OECzPFMzQTxxYU6=
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HCT116 NGjHW5RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MW[0PEBpenN? MmDuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlIh|ryPLh?= NEHQUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC3N|Y4Pid-MkiwO|M3PzZ:L3G+
BGC823 Mn7BRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXe0PEBpenN? MoDmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCER1O4NlMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO0Mlgh|ryPLh?= NGPEfmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC3N|Y4Pid-MkiwO|M3PzZ:L3G+
IOSE-144 NGfre|BCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4HO[lQ5KGi{cx?= NUHldoZkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJU3NGNTF2NDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzhwMTFOwG0v NF[zXoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC3N|Y4Pid-MkiwO|M3PzZ:L3G+
MCF7 NGD5WVZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnLYOFghcHK| NIXsUGpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK2MlE1KM7:TT6= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzMEi3NUc,OjhzMUC4O|E9N2F-
HCT116 NFrNUJNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVe0PEBpenN? NUOxenBqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM5NjNizszNMi=> NGHU[VA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxNFg4OSd-MkixNVA5PzF:L3G+
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HepG2 MkjZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYrVXZh{PDhiaILz NFTNWYRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0PU4xOiEQvF2u NHzlUos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxNFg4OSd-MkixNVA5PzF:L3G+
BCG823 NV6xT45lS3m2b4TvfIlkcXS7IHHzd4F6 MYS0PEBpenN? M{LzdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJETzh{MzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlEh|ryPLh?= MlPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUeyNFIoRjJ6MUG3NlAzRC:jPh?=
A549 NFqxNZJEgXSxdH;4bYNqfHliYYPzZZk> MlrCOFghcHK| MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMTFOwG0v NEfReZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxO|IxOid-MkixNVczODJ:L3G+
HepG2 M3z1NWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3zsZVQ5KGi{cx?= MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5LkKg{txONg>? M1Xnd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUG3NlAzLz5{OEGxO|IxOjxxYU6=
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ECA109 MnK0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1myV|Q5KGi{cx?= MnzSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ1GxNFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOwMlI2KM7:TT6= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzOUKwNEc,OjhzMUmyNFA9N2F-
K562 M3LVT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\HWVQ5KGi{cx?= NFnJUYpIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBYW1RzIHHzd4F6NCCLQ{WwJF0hOzhwNUig{txONg>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF{NkSzOkc,OjhzMk[0N|Y9N2F-
KKU-M214 NYCydHl2S3m2b4TvfIlkcXS7IHHzd4F6 NHPJd2I4OiCqcoO= M4fMWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtMXS2PMkG0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gN{44PiEQvF2u M3G1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUSwOVkzLz5{OEG0NFU6OjxxYU6=
HL60 MnXDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4PhVFQ5KGi{cx?= NFXyTWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEGuOlIh|ryPLh?= NUL5R45qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVI1OzBpPkK4NVUzPDNyPD;hQi=>
NCI-H1299 NX\JSZpXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV:0PEBpenN? MnHKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFEzQTliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFgvQTFizszNMi=> NV;SbXR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVI1OzBpPkK4NVUzPDNyPD;hQi=>
MCF7 NEHXU3VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXi3NkBpenN? NEjse29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuO|Uh|ryPLh?= Mn3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
Bel7402 NULBOXF{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVy3NkBpenN? MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNlUh|ryPLh?= NFH0O2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
MGC803 Mo\BRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmTlO|IhcHK| NWjyW5hZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvOTJizszNMi=> NY\YTWh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
K562 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3L6XFczKGi{cx?= NGq5T41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuOVQh|ryPLh?= M37qW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
HepG2 NFSwZ4lEgXSxdH;4bYNqfHliYYPzZZk> NF71e2o1QCCqcoO= M1\xR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61N{DPxE1w MorOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzN{SxNFcoRjJ6MUe0NVA4RC:jPh?=
Hep3B NYDkdYV3S3m2b4TvfIlkcXS7IHHzd4F6 MUG0PEBpenN? NFvTbWJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEmuO|Ih|ryPLh?= M4r3WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUe0NVA4Lz5{OEG3OFExPzxxYU6=
MCF7 NUfDRotNS3m2b4TvfIlkcXS7IHHzd4F6 MnfOO|IhcHK| MkfhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOS52IN88UU4> M{PSN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG5NFQ3Lz5{OEKxPVA1PjxxYU6=
HCT116 Mn;uR5l1d3SxeHnjbZR6KGG|c3H5 Ml\lO|IhcHK| MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDF6LkSg{txONg>? NGrjTno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxPVA1Pid-MkiyNVkxPDZ:L3G+
HuH7 M2PyV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnuzO|IhcHK| Ml6yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOjFizszNMi=> NFjyOZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxPVA1Pid-MkiyNVkxPDZ:L3G+
A549 M2G1NmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFLkNGwzPCCqcoO= NInTPXBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjJizszNMi=> M{Hk[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkW0Olk4Lz5{OEK1OFY6PzxxYU6=
HeLa MmjvR5l1d3SxeHnjbZR6KGG|c3H5 M1j4OFI1KGi{cx?= M3TzbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPCEQvF2u NITBXpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HepG2 Mn3DR5l1d3SxeHnjbZR6KGG|c3H5 NUPMfWRMOjRiaILz MoK0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPCEQvF2u M{Tub|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkW0Olk4Lz5{OEK1OFY6PzxxYU6=
COLO205 M2TrbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4XxVFI1KGi{cx?= MlfJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR29NVzJyNTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS57IN88UU4> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ3NE[5O{c,Ojh{NUS2PVc9N2F-
HepG2 NX6wNXZkS3m2b4TvfIlkcXS7IHHzd4F6 MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkGg{txONg>? M1SwUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mk[yOVI4Lz5{OEK2NlUzPzxxYU6=
Hep3B M{[yTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nTVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOlYh|ryPLh?= NVPKfYI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOlI2OjdpPkK4NlYzPTJ5PD;hQi=>
Bel7402 M{DCdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkXSO|IhcHK| NXGze5NGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDVwOUSg{txONg>? MmW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MEG4NVUoRjJ6M{CxPFE2RC:jPh?=
LO2 NYX0WpdPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml7IO|IhcHK| NUGybXp1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMU|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gN|IvPTR4IN88UU4> M3zyRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{CxPFE2Lz5{OEOwNVgyPTxxYU6=
HCT116 MlewR5l1d3SxeHnjbZR6KGG|c3H5 M3PV[2N6fG:2b4jpZ4l1gSCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OCB;IESxJO69VS5? NHr3Nos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOzOFY2PCd-MkizN|Q3PTR:L3G+
MCF7 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NYW4Rm1zS3m2b4TvfIlkcXS7IHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OCB;IESxMlUh|ryPLh?= M2LXZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O0OlU1Lz5{OEOzOFY2PDxxYU6=
HeLa M3u3cWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4H5b|Q5KGi{cx?= NIfDeGZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuNFIh|ryPLh?= NEfzW|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
HepG2 M{S1T2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVe0PEBpenN? NFTpWplCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{4{OSEQvF2u NXjKbZhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOlM1PDRpPkK4N|Y{PDR2PD;hQi=>
BGC823 NV\VeXRvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnjnOFghcHK| MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKJQ{iyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuN|ch|ryPLh?= NF[2S5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
SW1116 NIn4[W5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Ml;GOFghcHK| MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZMUGxOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUiuOVIh|ryPLh?= Moj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NkO0OFQoRjJ6M{[zOFQ1RC:jPh?=
Hep3B MmHxR5l1d3SxeHnjbZR6KGG|c3H5 NYXnWJVFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVEvQSEQvF2u MnPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|N{G2O|YoRjJ6M{exOlc3RC:jPh?=
MCF7 NHXtTY9EgXSxdH;4bYNqfHliYYPzZZk> Ml7WR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MDFOwG0v MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN5MU[3Okc,Ojh|N{G2O|Y9N2F-
HepG2 NInkeXVEgXSxdH;4bYNqfHliYYPzZZk> NVfRe4dnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvPiEQvF2u NFjvN2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO3NVY4Pid-MkizO|E3PzZ:L3G+
A549 M2L4[GN6fG:2b4jpZ4l1gSCjc4PhfS=> MkS1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|OD6yJO69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN5MU[3Okc,Ojh|N{G2O|Y9N2F-
MCF7 M4XJfGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUXIeGhlPDhidH:gO|IhcHK| MlmzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhidH:gO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvPjdizszNMi=> Mor3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OUWyNVgoRjJ6M{m1NlE5RC:jPh?=
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SGC7901 NFPjOWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVPvPFBUPDhidH:gO|IhcHK| MojwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVR1O3PVAyKGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF|LkK1JO69VS5? MmnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OUWyNVgoRjJ6M{m1NlE5RC:jPh?=
HepG2 Mof0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVi0PEB1dyB5MjDodpM> MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhidH:gO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjR2IN88UU4> NFzETWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO5OVIyQCd-MkizPVUzOTh:L3G+
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MCF7 NUL2Xo1vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnT6OFghcHK| MXzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCxMlY4KM7:TT6= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzOUc,Ojh2MECyN|U9N2F-
A549 NWj5NotmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXPFTJpiPDhiaILz MlnpS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNk4xQSEQvF2u MnLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MECyN|UoRjJ6NECwNlM2RC:jPh?=
DU145 NHjrOIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGi3dpM1QCCqcoO= MXjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gOU45OiEQvF2u NIXZdYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{PSd-Mki0NFAzOzV:L3G+
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A549 M3WxUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MljMOFghcHK| MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkGg{txONg>? M4nwe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NECwNlM5Lz5{OESwNFI{QDxxYU6=
HepG2 NISwOGRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX[0PEBpenN? NHTRN4ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE4yKM7:TT6= M2HUU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NECwNlM5Lz5{OESwNFI{QDxxYU6=
HCT116 MmXtRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoTpOFghcHK| MmXVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK2MlIh|ryPLh?= NXnkSWRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzhpPkK4OFAxOjN6PD;hQi=>
MCF7 NXXFcYJPS3m2b4TvfIlkcXS7IHHzd4F6 NYrGRphoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyxiSVO1NEA:KDdwOTFOwG0v M4O2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOxN|QyLz5{OESzNVM1OTxxYU6=
HepG2 M{XQNGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1:3[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{NCCLQ{WwJF0hQC5zIN88UU4> MnTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2M{GzOFEoRjJ6NEOxN|QyRC:jPh?=
HCT116 NGXSNVhEgXSxdH;4bYNqfHliYYPzZZk> NVrxUnpyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|LDDJR|UxKD1iOT65JO69VS5? M4DjN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOxN|QyLz5{OESzNVM1OTxxYU6=
PC3 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NWTSdlVSPDhiaILz MlvHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlIh|ryPLh?= NXPXPYt1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
A549 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M{jmU|Q5KGi{cx?= NGTXbVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjZizszNMi=> MlO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2M{G4PFEoRjJ6NEOxPFgyRC:jPh?=
HeLa MWHDfZRwfG:6aXPpeJkh[XO|YYm= M3LtWFQ5KGi{cx?= M{ey[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvQDZizszNMi=> NUG5cW5zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
DU145 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MWC0PEBpenN? NE\ydodEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOi5zODFOwG0v MoTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2M{G4PFEoRjJ6NEOxPFgyRC:jPh?=
MDA-MB-231 MYfDfZRwfG:6aXPpeJkh[XO|YYm= NGKyVlI1QCCqcoO= NXzsbFlpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE4{OyEQvF2u NYXze49KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E5QDFpPkK4OFMyQDhzPD;hQi=>
HGC27 M{ezWmN6fG:2b4jpZ4l1gSCjc4PhfS=> NInq[HM1QCCqcoO= NGr0Xo1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJT0N{NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwN{Kg{txONg>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUi4NUc,Ojh2M{G4PFE9N2F-
MGC803 NUHtVFJRSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYO3[YpkPzJiaILz MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj61OkDPxE1w MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3NkCzNUc,Ojh2NU[wN|E9N2F-
HGC27 Mn3qRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1jKTFczKGi{cx?= NGPId3JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4MlIzKM7:TT6= NY\Tdm5xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVYxOzFpPkK4OFU3ODNzPD;hQi=>
NCI-H1650 NYTYSItPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWXPXmE4PzJiaILz M2HpT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPjVyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi53MjFOwG0v M3nCNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEW2NFMyLz5{OES1OlA{OTxxYU6=
HCT116 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWO3NkBpenN? MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND6xOkDPxE1w NXfrdoJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVgyOzNpPkK4OFU5OTN|PD;hQi=>
PC3 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{jkcVczKGi{cx?= Mnu4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkOzJO69VS5? M1u3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEW4NVM{Lz5{OES1PFE{OzxxYU6=
MCF7 NYr2elNrSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3vLOlczKGi{cx?= MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ6LkezJO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3OEGzN{c,Ojh2NUixN|M9N2F-
HepG2 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWW3NkBpenN? M{S0OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlA4KM7:TT6= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3OEGzN{c,Ojh2NUixN|M9N2F-
Caco2 NE[1T2pEgXSxdH;4bYNqfHliYYPzZZk> MkPuNlQhcHK| NHn2VnREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxMjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzFizszNMi=> MnvyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NkO3PFUoRjJ6NE[zO|g2RC:jPh?=
HeLa NIju[3ZEgXSxdH;4bYNqfHliYYPzZZk> M{HVcFczKGi{cx?= M2exWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iMUOuPUDPxE1w NYjIXm9zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFg5PjJpPkK4OFg5QDZ{PD;hQi=>
HT-29 NVf3e4xuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3vXblczKGi{cx?= MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Lkmg{txONg>? NGnyUFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2OSd-Mki0PVQzPTF:L3G+
PC3 MnjERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnXJO|IhcHK| MnPERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkOg{txONg>? MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OUSyOVEoRjJ6NEm0NlUyRC:jPh?=
HepG2 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUfjTnE5PzJiaILz NIPVZ45CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyPU4yKM7:TT6= MnrVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OUSyOVEoRjJ6NEm0NlUyRC:jPh?=
SW620 NYnPdYl4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkPkO|IhcHK| MkH2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{[yNEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6wPEDPxE1w NYHScpB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5PDVpPkK4OVI2QDR3PD;hQi=>
CFPAC-1 MnfVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHnpPZI4OiCqcoO= MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOIUFHDMVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVQh|ryPLh?= NFfOe5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEWyOVg1PSd-Mki1NlU5PDV:L3G+
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HepG2 MlfjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEPQWXg4OiCqcoO= NWDKWmFkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPE46KM7:TT6= M3i0OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUK1PFQ2Lz5{OEWyOVg1PTxxYU6=
HCT116 NWDJc5pFS3m2b4TvfIlkcXS7IHHzd4F6 M1GzNVQ5KGi{cx?= MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2MT65JO69VS5? MnHYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3M{K2OlkoRjJ6NUOyOlY6RC:jPh?=
A549 NG\3NJNEgXSxdH;4bYNqfHliYYPzZZk> NWnFZok6PzJiaILz MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBYW1R6IHHzd4F6NCCLQ{WwJF0hPC55IN88UU4> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV3OEm3NEc,Ojh3NUi5O|A9N2F-
HeLa MULDfZRwfG:6aXPpeJkh[XO|YYm= MlXUO|IhcHK| Mo[4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhX1OWODDhd5NigSxiSVO1NEA:KDVwMzFOwG0v MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV3OEm3NEc,Ojh3NUi5O|A9N2F-
MCF7 NYHQfJd4S3m2b4TvfIlkcXS7IHHzd4F6 NHXyZVM4OiCqcoO= NILNc|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iNT62JO69VS5? MkfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NUi5O|AoRjJ6NUW4PVcxRC:jPh?=
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MGC803 NWG0TZROSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnPJO|IhcHK| MmjpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPR1O4NFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuNlQh|ryPLh?= M3rlc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEe1NVU3Lz5{OUS3OVE2PjxxYU6=
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SMMC7721 MmrhRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWiyOEBpenN? NHPLeJFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPNUWM4PzJzIHPlcIx{KGGodHXyJFI1KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkS3JO69VS5? M1\rPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEm5OFkxLz5{OUS5PVQ6ODxxYU6=
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SKOV3 M1jRd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYm0PEBpenN? NXv2SHkyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4LkO0JO69VS5? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7MkO2PEc,OzByOUKzOlg9N2F-
HepG2 M4XTWmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\tOFghcHK| MlThR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMyNjl6IN88UU4> NYnV[otORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVI{PjhpPkOwNFkzOzZ6PD;hQi=>
Bel7404 MkPTR5l1d3SxeHnjbZR6KGG|c3H5 MYO0PEBpenN? MnHsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoVtPzRyNDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwMkGg{txONg>? Mlm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUKzOlgoRjNyMEmyN|Y5RC:jPh?=
NCI-H460 NULMUpo{S3m2b4TvfIlkcXS7IHHzd4F6 NFjT[Gs1QCCqcoO= NGfZWFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEWuOFQh|ryPLh?= M4rUd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEmyN|Y5Lz5|MEC5NlM3QDxxYU6=
RKO Mn:0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlPiOFghcHK| NUPDVW5bT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWkuRIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFyLkKg{txONg>? MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzME[yPFkoRjNyMUC2Nlg6RC:jPh?=
LoVo M1zGW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXG0PEBpenN? NEXRXHRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNd1[xIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFzLkWg{txONg>? M2HP[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUC2Nlg6Lz5|MEGwOlI5QTxxYU6=
MCF7 M1SxcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml3HO|IhcHK| MnLVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nj6xOEDPxE1w Mn;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEK2NVIoRjNyMUSyOlEzRC:jPh?=
MGC803 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYS3NkBpenN? NGPGd2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|EvODRizszNMi=> M2TUdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUSyOlEzLz5|MEG0NlYyOjxxYU6=
HCT116 M3TsW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlzMO|IhcHK| NXvafmI4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM5NjNizszNMi=> MkTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEK2NVIoRjNyMUSyOlEzRC:jPh?=
HepG2 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFm2Zm04OiCqcoO= M4jLXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES3Mlk4KM7:TT6= NWG4R5pnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOFI3OTJpPkOwNVQzPjF{PD;hQi=>
A549 NHy5W3pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVXqUmFPPzJiaILz NH6y[JJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNFUh|ryPLh?= NGqxN3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0N|E2Oyd-M{CyOFMyPTN:L3G+
Bel7402 MnnlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NV3TSnN3PzJiaILz M3zqfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVgvPjVizszNMi=> NHP6Noo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0N|E2Oyd-M{CyOFMyPTN:L3G+
MCF7 NXzCT2lQSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWHBSHQ1PzJiaILz NXf6b|g4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyO{45QSEQvF2u MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ2M{G1N{c,OzB{NEOxOVM9N2F-
T84 NXHvOIlySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3T6UVMh\GG7cx?= NHXWXIhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS4OEBk\WyuczDh[pRmeiB|IHThfZMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFMvPCEQvF2u NF36PVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0PFY2Pyd-M{CyOFg3PTd:L3G+
A549 NXL4U4dHSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NE\rem4{KGSjeYO= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTC3MlEh|ryPLh?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ2OE[1O{c,OzB{NEi2OVc9N2F-
MCF7 NVfFOI5mSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M37vWFMh\GG7cx?= MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTC3Mlgh|ryPLh?= NXnCUWVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyOFg3PTdpPkOwNlQ5PjV5PD;hQi=>
A549 NWnWNY12S3m2b4TvfIlkcXS7IHHzd4F6 M4XHWlczKGi{cx?= MnGyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE4{KM7:TT6= NGHSUlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEOxPFQ1OCd-M{CzNVg1PDB:L3G+
HeLa MoLuR5l1d3SxeHnjbZR6KGG|c3H5 MXq3NkBpenN? M17GVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjd3IN88UU4> NYLVVVZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVg1PDBpPkOwN|E5PDRyPD;hQi=>
HCT116 Mn;6R5l1d3SxeHnjbZR6KGG|c3H5 Mn7rO|IhcHK| Mo\jR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS53NjFOwG0v M1zwOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G4OFQxLz5|MEOxPFQ1ODxxYU6=
NCI-H460 NUfNTlZXS3m2b4TvfIlkcXS7IHHzd4F6 MWi3NkBpenN? Mor0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLke1JO69VS5? M2PDUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G4OFQxLz5|MEOxPFQ1ODxxYU6=
HCT15 Mn;PR5l1d3SxeHnjbZR6KGG|c3H5 MVy3NkBpenN? Ml\lR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEyNjh5IN88UU4> M{LRVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G4OFQxLz5|MEOxPFQ1ODxxYU6=
MDA-MB-231 MVfDfZRwfG:6aXPpeJkh[XO|YYm= MVi3NkBpenN? MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MT6wOUDPxE1w NUnk[HJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVg1PDBpPkOwN|E5PDRyPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / PUMA / c-PARP; 

PubMed: 25965911     


(A) HCT-116 cells were treated with various doses of 5-FU for 24 hours (B) HCT-116 cells were treated with 200 uM 5-FU, then harvested at different time points after stimulation. The expression of p53, PUMA, cleaved PARP and P-Akt(S473) were detected by western blotting in different conditions.

25965911
Immunofluorescence
caveolin-3; 

PubMed: 23646193     


Cells were stained with an antibody against caveolin-3 (green) and with DAPI (blue). (A) control cells (top images), 10 mM 5-FU (middle images), 50 mM 5-FU (bottom images). Merged images are shown at the right of each panel.

phospho-histone H3 ; 

PubMed: 23646193     


Cells were grown for 24 h, treated with 5-FU and stained with an anti-phospho-histone H3 antibody (red) and with DAPI (blue). (A) control cells, (B) 0.1 mM 5-FU and (C) 1 mM 5-FU. 

p65 / p-p65(Ser536) / p53 / p-p53(Ser15); 

PubMed: 24587255     


E–H, Immunocytochemistry of p65 and p53 induction and localization by 5-FU treatment for the indicated cell lines. p65 (red), phosphor-p65 (Ser536; red), p53 (green), phospho-p53 (Ser15; red), and DAPI (blue) staining of the nucleus without (control) and with 5-FU treatment. 

Sox2 / Oct4 / Nanog / ABCG2; 

PubMed: 27009861     


(A) Immunofluorescence staining of Sox2, Oct4 and Nanog in HBE cells with or without 5-FU treatment. In untreated HBE cells, few Sox2, Oct4 or Nanog-positive cells were observed. After 5-FU treatment, the number of Sox2, Oct4 or Nanog-positive cells increased remarkably. Nuclei were counterstained with DAPI (blue). (B) Immunofluorescence staining of ABCG2 in HBE cells with or without 5-FU treatment. 

β-catenin; 

PubMed: 30111797     


Immunofluorescence detection of β-catenin in HCT-8 cells. Scale bar, 20 μm.

non-phospho β-catenin; 

PubMed: 28588704     


Effect of enhanced WNT signaling in Ell3 OE cells. Localization of non-phosphorylated β-catenin was analyzed by immunocytochemical staining in (A) control MCF-7 and (B) Ell3 OE treated with various 5-FU concentrations.

23646193 24587255 27009861 30111797 28588704
Growth inhibition assay
Cell viability; 

PubMed: 25965911     


Cells viability was analyzed using Cell Counting Kit-8 at 0, 3, 6, 12 and 24 hours after (A) 50, 100, 200, or 400 uM 5-FU treatment in HCT116 cells.

Cell proliferation; 

PubMed: 30250641     


(A) Cell proliferation assay with resveratrol in HCT116. Cells were treated with resveratrol at 0 ~ 200 μM for 72 hours and applied to MTS assay. (B) HCT116 cells were treated with 5-FU at 0~200 μM for 72 hours. (C)HCT116 cells were treated with resveratrol at 0 ~ 200 μM combined with 5-FU at 10 μM for 72 hours and applied to MTS assay. (D) DLD1 cell proliferation assay with resveratrol at 0 ~ 200 μM for 72 hours. (E) DLD1 cells were treated with 5-FU at 0~ 200 μM for 72 hours. (F) DLD1 cells were treated with resveratrol combined with 5-FU at 10 μM for 72 hours. Error bars represent standard deviation.

25965911 30250641
In vivo Adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. [1] 100mg/kg Adrucil significantly suppresses tumor growth of murine colon carcinomas Colon 38 with tumor-doubling time (TD), growth-delay factor (GDF), and T/C of 26.5 days, 4.4, and 14%. [5]

Protocol

Cell Research:[4]
- Collapse
  • Cell lines: Human colon carcinoma cell line HT-29
  • Concentrations: ~25 μM
  • Incubation Time: 7 days
  • Method: Growth inhibition is measured after treatment of cells with Adrucil for 7 days in 96-well plates (4000 HT-29 cells/well in RPMI 1640 medium with 10% dialyzed fetal bovine serum); increasing concentrations of Adrucil are added after allowing for cell attachment overnight. At the end of incubation, cells are rinsed three times with phosphate-buffered saline (pH 7.4), fixed with 10% trichloroacetic acid for 60 min at 4 ℃, washed five times with deionized water, and stained with 0.4% sulforhoda-mine B solution for 15 min at room temperature. Unstained sulforhodamine B is removed by rinsing with 1% glacial acetic acid. Afterwards, stained cell proteins are dried and dissolved with 10 mM Tris-HCl. The optical density value is measured using a detector at 540 nm wavelength.
    (Only for Reference)
Animal Research:[5]
- Collapse
  • Animal Models: Murine colon carcinomas Colon 38
  • Dosages: 100 mg/kg
  • Administration: i.p. weekly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 26 mg/mL (199.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
saline (warming)
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 130.08
Formula

C4H3FN2O2

CAS No. 51-21-8
Storage powder
in solvent
Synonyms NSC 19893
Smiles C1=C(C(=O)NC(=O)N1)F

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04158349 Recruiting Drug: Oxaliplatin|Drug: mFOLFIRI Colorectal Cancer|Appendiceal Cancer|Peritoneal Carcinoma University of Utah June 11 2020 Phase 1
NCT04370418 Not yet recruiting Drug: short course chemo-radiation with 5-fluorouracil Neo-adjuvant Short Course Chemo-radiation in Locally Advanced Cancer Rectum Assiut University May 2020 --
NCT04274933 Terminated Drug: Venetoclax|Drug: Capecitabine Breast Cancer|Cancer AbbVie May 21 2020 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    I was wondering if the product #s1209 (5-fluorouracil) is suitable to inject into mice ?

  • Answer:

    S1209 is suitable to inject (I.P.) into mice as indicating in this paper: http://www.ncbi.nlm.nih.gov/pubmed/8995503.

DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID