Fluorouracil (5-Fluorouracil, 5-FU)

Catalog No.S1209 Synonyms: NSC 19893

For research use only.

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 148 publications

Purity & Quality Control

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Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 M3vaUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjVO|LDqGkEoB?= M{\JdGlEPTB-IEK1JO69\y:vTB?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
HL-60 M4XacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXGc|g4OsLiaNMg MXnJR|UxRThwNkCxJO69\y:vTB?= M2fVSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
HT-29 NGfEUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzrU5U4OsLiaNMg M1;jRmlEPTB-IEK1JO69\y:vTB?= MknmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
MCF-7 M32zWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLxO|LDqGkEoB?= NGPkdGFKSzVyPUKwJO69\y:vTB?= Moq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
L1210/0 MXfGeY5kfGmxbjDhd5NigQ>? MmToSYZn\WO2IH;uJGwyOjFyL{CgZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IECuN{DPxE1w NI\odoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[yNlc5Lz5{M{[yNlc5RC:jPh?=
CCRF-CEM M3KxbWZ2dmO2aX;uJIF{e2G7 M{G5TmVn\mWldDDvckBES1KILVPFUUBk\WyuczDpckBkfWy2dYLlMEBKSzVyIE2gNkDPxE1w NEe1coY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[yNlc5Lz5{M{[yNlc5RC:jPh?=
P388 NWG3fodbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWf3VYFuPDhiaILz NG\5UmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGCzPFgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlA6KM7:TT6= M1PIU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{i0OFkoRjJ5N{i0OFk9N2F-
HT-29 NXn3[W9LSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWm5OkBpenN? M3K5[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlkh|ryPLh?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd6NES5K|4zPzd6NES5QE9iRg>?
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SW480 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1H2dFczKGi{cx?= NHPO[WFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gPE4yKM7:TT6= NY\BV2NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NlQ3PTVpPkG3OVI1PjV3PD;hQi=>
MDA-MB-435S NUHWfoNuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEPpRoY4OiCqcoO= NWTLW2VJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEG0MlUh|ryPLh?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV{NE[1OUc,OTd3MkS2OVU9N2F-
HCCLM7 Ml:yRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MkPRO|IhcHK| MnLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ1PMUVch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTCxPE43KM7:TT6= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV{NE[1OUc,OTd3MkS2OVU9N2F-
Caco-2 NUHkWYl[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\PdWRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBE[WOxLUKgZ4VtdHNuIFnDOVAhRSBzLkWg{txONg>? MkmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixNlkoRjF5NUS4NVI6RC:jPh?=
MCF7 M4jjZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIHMT3E4OiCqcoO= MmDaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{whUUN3MDC9JFAvOyEQvF2u MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
HCT116 NF3MRmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWK3NkBpenN? M1XrR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDJwODFOwG0v MojxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixPVgoRjF5NUS4NVk5RC:jPh?=
SW480 MkTjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2npWlczKGi{cx?= NV\oTHF4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5OCClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVAhRSB|LkWg{txONg>? NIHvfHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
SW48 Ml;URY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Ml7iO|IhcHK| MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNEigZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyIE2gOU4{KM7:TT6= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
DLD1 M2[0XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1HMZmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRNTDFiY3XscJMtKEmFNUCgQUA1NjVizszNMi=> M3WySVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUWzOlg2Lz5zN{W1N|Y5PTxxYU6=
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colon cancer cell Mmf2R5l1d3SxeHnjbZR6KGG|c3H5 M2LMb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{whT0l3MDC9JFUvPzVizszNMi=> MlHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkKzOlUoRjF5NU[yN|Y2RC:jPh?=
A549 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NG\XUZY1QCCqcoO= NIO3SYFEgXSxdH;4bYNqfHliYXfhbY5{fCCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? M{juZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkC0N|k1Lz5zN{[wOFM6PDxxYU6=
L1210 Mo\ER5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= MX\DfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOsJGlEPTBiPTCwMlI5KM7:TT6= Ml62QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7M{G4OlIoRjF5OUOxPFYzRC:jPh?=
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Molt4/C8 M13MZ2N6fG:|dHH0bYMh[WO2aY\peJkh[XO|YYm= MmD1R5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3vcJQ1N0N6IHPlcIx{NCCLQ{WwJF0hOjNizszNMi=> M4n2dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUOxPFYzLz5zN{mzNVg3OjxxYU6=
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embryonic cell NID5d3VHfW6ldHnvckBie3OjeR?= M4jCPWlv\HWldHnvckBw\iClbHXheoFo\SCjcoLld5QhcW5iZX3idplwdmmlIHPlcIx{KG:oIIP0ZYdmKDhiWHXuc5B2eyCuYXX2bZMh[myjc4T1cIFmNCCLQ{WwJF0hOjZwODFOwG0v Mo\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{N{G1OVgoRjF6MkexOVU5RC:jPh?=
HepG2 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NWPE[3UzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSBzOD63JO69VS5? NGm5XFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwNlM{Pid-MUizNFI{OzZ:L3G+
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HepG2 NU[wXpo6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1;vb|Mh\GG7cx?= MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? NIrldJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESyOFE2PSd-MUi0NlQyPTV:L3G+
CEM M3jySGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlPFN{Bl[Xm| NGLzdYxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPFUUBk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6yN{DPxE1w MlnRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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HeLa NFXzPHZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1fXc|Mh\GG7cx?= MoHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNjFOwG0v M2DJWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEK0NVU2Lz5zOESyOFE2PTxxYU6=
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LLC Mn[2R5l1d3SxeHnjbZR6KGG|c3H5 NEX6cHE4OiCqcoO= MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDMUGMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOVkh|ryPLh?= MojsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NECyN|MoRjF6NESwNlM{RC:jPh?=
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BCG823 M3LGSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYL0OohVOyCmYYnz NI\PXHVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS0d6MkOgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwMUWg{txONg>? NXzNUGZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFA6OjVpPkKyNFAxQTJ3PD;hQi=>
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prostate cancer cell Mo\LR5l1d3SxeHnjbZR6KGG|c3H5 NV;YTpAxPDhiaILz NFm5eXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTpcoctKEeLNUCgQUAzOi55IN88UU4> M3PxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEW2Nlc4Lz5{MkC1OlI4PzxxYU6=
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HEK293 M4q1c2N6fG:2b4jpZ4l1gSCjc4PhfS=> NU\zbZBtOiCmYYnz NUDBNWZ{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEWNMkmzJINmdGy|IHHmeIVzKDJiZHH5d{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NEA:KDR{Lkmg{txONg>? NFHiOYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5N|c3OSd-MkKwPVM4PjF:L3G+
colon cancer cell Ml;NS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLLOFghcHK| MofvS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCJSUWwJF0hQC52IN88UU4> NUGwflhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVkyPTFpPkKyNVE6OTVzPD;hQi=>
leukemia cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHPVbGw1QCCqcoO= NYLpdnZ5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUAyPS5zIN88UU4> M4XGXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUG5NVUyLz5{MkGxPVE2OTxxYU6=
prostate cancer cell M3LoeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkTiOFghcHK| M4LiSWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJJBzd3O2YYTlJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOgZpkh[2:3bITldkBkd3WwdHXyJI1mfGixZDygS2k2OCB;IEKyMlch|ryPLh?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUG1NUc,OjJzMUmxOVE9N2F-
renal cancer cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVm0PEBpenN? MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUA1PS54IN88UU4> NIH0XZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVE2OSd-MkKxNVkyPTF:L3G+
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MCF7 NGP1d3VEgXSxdH;4bYNqfHliYYPzZZk> MkLpO|IhcHK| MnrZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQh|ryPLh?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|MEGzNkc,OjJzM{CxN|I9N2F-
A549 NUj2Zot4S3m2b4TvfIlkcXS7IHHzd4F6 Mnj3NlQhcHK| NH;URlBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjZ2IN88UU4> NEKxcYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG4NlkzPid-MkKxPFI6OjZ:L3G+
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HepG2 M4PE[GFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVfTeGIxPDhiaILz M3XyPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlkzKM7:TT6= NEfmdmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwPVQ5Pid-MkKyNFk1QDZ:L3G+
NCI-H460 NUTlTnFoS3m2b4TvfIlkcXS7IHHzd4F6 NIr0WHBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczygTWM2OCB;IEig{txONg>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{S1NUc,OjJ{OEO0OVE9N2F-
SMMC7721 NITnc5dEgXSxdH;4bYNqfHliYYPzZZk> MnryR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNuIFnDOVAhRSBzNTFOwG0v NYiwcGhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1PTFpPkKyNlg{PDVzPD;hQi=>
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HT1080 M1G4RWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYDtWYpUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRzMEiwJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvODZizszNMi=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
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Hep2 NVPPXlBrS3m2b4TvfIlkcXS7IHHzd4F6 NFXsWGlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlU5KM7:TT6= NYrvVop[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
MCF7 NHXGWoZEgXSxdH;4bYNqfHliYYPzZZk> NXH1UoFOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE42QCEQvF2u MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
A549 NXjWNos2S3m2b4TvfIlkcXS7IHHzd4F6 NULTS4NxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNU42OiEQvF2u MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
MDA231 NWHpSXRGS3m2b4TvfIlkcXS7IHHzd4F6 MmPUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOxMlU4KM7:TT6= NVPHSnR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
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MKN45 MofPR5l1d3SxeHnjbZR6KGG|c3H5 NXW2VFl{PDhiaILz M13hVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1MVjR3IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OS55MzFOwG0v M3T0cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEC5OVU5Lz5{MkiwPVU2QDxxYU6=
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2008 NFexSYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlG3S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gNlAxQCClZXzsd{BjgSClconzeIFtKH[rb3zleEBie3OjeTygTWM2OCB;IESuNkDPxE1w NYPDO4Y6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|U1OTRpPkKzNFc2PDF2PD;hQi=>
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HepG2 MkHoR5l1d3SxeHnjbZR6KGG|c3H5 M3\L[FczKGi{cx?= NF3wXlFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjFwOTFOwG0v MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5OUi2OEc,OjN{N{m4OlQ9N2F-
SGC7901 NXfkV5JYS3m2b4TvfIlkcXS7IHHzd4F6 NYTOWWx2PzJiaILz MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTS2M4QTBzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzQC53IN88UU4> M4[xUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mke5PFY1Lz5{M{K3PVg3PDxxYU6=
HCT116 M1ewfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2\vOlQ5KGi{cx?= NFi0[2tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliU4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFMvPTZizszNMi=> MlrqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEW5NVkoRjJ|M{C1PVE6RC:jPh?=
B16F10 NXP3N3dsSW62aXPhcoNmeiCjc4PhfS=> MXK0PEBpenN? NVXKVG9bSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KG2xdYPlJGIyPkZzMDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOS52MTFOwG0v NGPrV2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxNlk1QSd-MkOzNVI6PDl:L3G+
SGC7901 MXHBcpRq[2GwY3XyJIF{e2G7 M4rCbFQ5KGi{cx?= NH7PS49CdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1Pi5|NTFOwG0v MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzMkm0PUc,OjN|MUK5OFk9N2F-
HeLa MmrLRY51cXS3bX;yJIF{e2G7 MnnyOFghcHK| MY\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOE44QCEQvF2u NG\kPYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{PSd-MkOzNVM3OzV:L3G+
A549 M37WTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LjZ|Q5KGi{cx?= MXPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlY1KM7:TT6= MoftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|NUO3N|coRjJ|M{WzO|M4RC:jPh?=
QGY7701 MknjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV60PEBpenN? MmDzS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVWd[PzdyMTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwMzFOwG0v M3Ts[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{WzO|M4Lz5{M{O1N|c{PzxxYU6=
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MGC803 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NH7xeFc4OiCqcoO= M1zKUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6wNUDPxE1w M{nBPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{WzO|Q{Lz5{M{O1N|c1OzxxYU6=
MCF7 NV3vO2hwS3m2b4TvfIlkcXS7IHHzd4F6 MVq3NkBpenN? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA4NjV2IN88UU4> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3M{e0N{c,OjN|NUO3OFM9N2F-
PC3 M4LoTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGXGdlE4OiCqcoO= NET5bmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5LkC3JO69VS5? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3M{e0N{c,OjN|NUO3OFM9N2F-
colon cancer MmXwR5l1d3SxeHnjbZR6KGG|c3H5 NHjjZo41QCCqcoO= NILNWGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBkd2yxbjDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dHCqb4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOD60JO69VS5? Mn3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2N{S4PVkoRjJ|NEe0PFk6RC:jPh?=
leukemia M1X5bGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWfnTHdpPDhiaILz NIXvc5lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4XsdIhwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUAyPS5zIN88UU4> Ml\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2N{S4PVkoRjJ|NEe0PFk6RC:jPh?=
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renal cancer NUjhelVvS3m2b4TvfIlkcXS7IHHzd4F6 M2rvU|Q5KGi{cx?= MnHKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxxcG:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDR3Lk[g{txONg>? M{Die|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEe0PFk6Lz5{M{S3OFg6QTxxYU6=
MCF7 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MUS0PEBpenN? NI\adm9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPi55IN88UU4> NHS0OYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5NFE2QSd-MkO0PVAyPTl:L3G+
HepG2 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NV3QNmh5PDhiaILz MmOzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIzNjhizszNMi=> NHWwfIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5NFE2QSd-MkO0PVAyPTl:L3G+
SGC7901 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NEiyR2M1QCCqcoO= NX3IRXM4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuPUDPxE1w NGfxN489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5NFE2QSd-MkO0PVAyPTl:L3G+
THP1 M1nrZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml\KOFghcHK| M3LkXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVFjQNUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFEh|ryPLh?= NVO4NYRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NFEyOTNpPkKzOVAyOTF|PD;hQi=>
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Hep2 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NEfETGY1QCCqcoO= MnHFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYCyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBKSzVyIE2gOE42KM7:TT6= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzVyMUGxN{c,OjN3MEGxNVM9N2F-
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CEM MVHDfZRwfG:6aXPpeJkh[XO|YYm= NIj5VIY4OiCqcoO= NHPLXYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBETU1iY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMzKM7:TT6= NUP4Zmc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|U{OjJpPkKzOVM2OzJ{PD;hQi=>
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K562 NYrWUlZMS3m2b4TvfIlkcXS7IHHzd4F6 MUS0PEBpenN? NVLxWml{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwNUWg{txONg>? M3nFO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUW4NlM5Lz5{M{W1PFI{QDxxYU6=
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HT1080 MnjMR5l1d3SxeHnjbZR6KGG|c3H5 MX20PEBpenN? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM2NjZ{IN88UU4> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
HepG2 NH\tO|dEgXSxdH;4bYNqfHliYYPzZZk> MoruOFghcHK| M2rNRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OC5|NDFOwG0v NFL4R4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
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EC9706 NV\JVG9[S3m2b4TvfIlkcXS7IHHzd4F6 NIPBVYo4OiCqcoO= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFR|k4ODZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOzJizszNMi=> M1rTelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NVk{Lz5{M{[0OFE6OzxxYU6=
MGC803 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NUW0SWpKPzJiaILz MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvOTRizszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
MCF7 MoPrR5l1d3SxeHnjbZR6KGG|c3H5 MYW3NkBpenN? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlM{KM7:TT6= M3vCeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NVk{Lz5{M{[0OFE6OzxxYU6=
SMMC7721 M{npUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUS3NkBpenN? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwN{Gg{txONg>? NH;YdpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFE6Oyd-MkO2OFQyQTN:L3G+
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HCT116 MnrpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYm3NkBpenN? Ml25RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuOVMh|ryPLh?= MlHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
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colon cancer NY\2VFRXS3m2b4TvfIlkcXS7IHHzd4F6 NES2cIc1QCCqcoO= MmLsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJiYX7hcJl{cXNuIFfJOVAhRSB6LkSg{txONg>? NYTUVYRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
leukemia NY[2WlhNS3m2b4TvfIlkcXS7IHHzd4F6 M1rBSVQ5KGi{cx?= NGnO[ZVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMh[nliY3;1cJRmeiClb4XueIVzKGGwYXz5d4l{NCCJSUWwJF0hOTVwMTFOwG0v NV\Ze5RsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
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SH-SY5Y NWrtNXVxS3m2b4TvfIlkcXS7IHHzd4F6 NH3Yd444OiCqcoO= NGrwRWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUC2VWUXZJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkm3JO69VS5? NEO5dmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU4OSd-MkO2PFU2PzF:L3G+
HCT116 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NUmzN|lsPzJiaILz M{H6bWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5{NDFOwG0v M2fVOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nki1OVcyLz5{M{[4OVU4OTxxYU6=
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SGC7901 M4r4cGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXi0PEBpenN? M3OyVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwMESg{txONg>? M2XXTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUKwNlQ3Lz5{M{myNFI1PjxxYU6=
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HeLa NUHHVWIzS3m2b4TvfIlkcXS7IHHzd4F6 MkTLOFghcHK| NH3YNmFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPi53MjFOwG0v M3y3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUKwNlQ3Lz5{M{myNFI1PjxxYU6=
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HepG2 NVPROXVMS3m2b4TvfIlkcXS7IHHzd4F6 M2CyV|Q5KGi{cx?= NXHrSm5OS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ7Lkm4JO69VS5? NVP4fYFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
A549 MonYR5l1d3SxeHnjbZR6KGG|c3H5 Ml\pOFghcHK| M{Xoe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM1NjN|IN88UU4> NWHxcoZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
NCI-H460 Mmf3R5l1d3SxeHnjbZR6KGG|c3H5 NVviW2VWPDhiaILz NWLh[G5lS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES0MlA1KM7:TT6= NXiyOm92RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
leukemia NX71[YVbS3m2b4TvfIlkcXS7IHHzd4F6 MUG0PEBpenN? NW\5d4pkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEGuOVEh|ryPLh?= M3izcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm0N|I5Lz5{M{m5OFMzQDxxYU6=
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prostate cancer NHPhVoZEgXSxdH;4bYNqfHliYYPzZZk> M3HmWFQ5KGi{cx?= NYfPfFNMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKxc4TheIUh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{Mj63JO69VS5? NVfWRVQxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVQ{OjhpPkKzPVk1OzJ6PD;hQi=>
renal cancer MXfDfZRwfG:6aXPpeJkh[XO|YYm= MWq0PEBpenN? NUDOXHNIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA1PS54IN88UU4> NEn4VnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5OFMzQCd-MkO5PVQ{Ojh:L3G+
A375-S2 M1vVcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkGwOFghcHK| NGS5U3JIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIFGzO|UuWzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvPjdizszNMi=> NVrmPWhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
HeLa MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVm0PEBpenN? MkLRS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkO0JO69VS5? NUPvbpZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
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MCF7 M{\jcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\tPVQ5KGi{cx?= NVj2SJB[T3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNU42KM7:TT6= M12wT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm5NFQ3Lz5{M{m5PVA1PjxxYU6=
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HCT116 MoflS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTBO5dwPDhiaILz NYDC[HAxT3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4Njd4IN88UU4> M3\kbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm5NFQ3Lz5{M{m5PVA1PjxxYU6=
HT1080 NXXsR2ZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYH4enZpPDhiaILz M{TYT2dzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iSGSxNFgxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzOU43OiEQvF2u M4LyTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm5NFQ3Lz5{M{m5PVA1PjxxYU6=
HepG2 MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4W5R|Q5KGi{cx?= MmXxS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNECuN|Qh|ryPLh?= NYDub3pRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
A549 NIPScoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TYUVQ5KGi{cx?= NV3lUpdLT3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0OE4xPSEQvF2u NHzpWoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1Pid-MkO5PVkxPDZ:L3G+
QSG7701 NYPtem4{S3m2b4TvfIlkcXS7IHHzd4F6 MnS1OFghcHK| MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRV2c4PzBzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwNjFOwG0v NUm0bmV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVM1OTVpPkK0NFE{PDF3PD;hQi=>
HepG2 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NEHjSGc1QCCqcoO= NWjE[IhTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMUKuOFgh|ryPLh?= M1jSZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGzOFE2Lz5{NECxN|QyPTxxYU6=
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Hep M3[3VWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmXYOFghcHK| M4jWXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= NGjCVFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC1OlE1Pid-MkSwOVYyPDZ:L3G+
IMR32 NYTBSpJzS3m2b4TvfIlkcXS7IHHzd4F6 NVTIUI1kPDhiaILz MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDJUXI{OiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNU4{KM7:TT6= M3PkTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEW2NVQ3Lz5{NEC1OlE1PjxxYU6=
A549 NITPVW9EgXSxdH;4bYNqfHliYYPzZZk> MVSyOEBpenN? NVrvTHQxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5zIN88UU4> NHrGNGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC2NFQ5Pid-MkSwOlA1QDZ:L3G+
HeLa NWj1b3hOS3m2b4TvfIlkcXS7IHHzd4F6 NEDwUZAzPCCqcoO= MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlEh|ryPLh?= NVnyWY1yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOlA1QDZpPkK0NFYxPDh4PD;hQi=>
MCF7 Ml\IR5l1d3SxeHnjbZR6KGG|c3H5 MVmyOEBpenN? NUC3e3p[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5{IN88UU4> NXrrbI1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOlA1QDZpPkK0NFYxPDh4PD;hQi=>
DU145 MUfDfZRwfG:6aXPpeJkh[XO|YYm= M3S1b|I1KGi{cx?= NHTnSoZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5|IN88UU4> NXXUOY9lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOlA1QDZpPkK0NFYxPDh4PD;hQi=>
MGC803 MY\DfZRwfG:6aXPpeJkh[XO|YYm= M4\kSFczKGi{cx?= MkHrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4LkmyJO69VS5? M{fxelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEe3NVgzLz5{NEC3O|E5OjxxYU6=
MCF7 M{Pme2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYPzVGJFPzJiaILz Mn\yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy53NDFOwG0v MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB5N{G4Nkc,OjRyN{exPFI9N2F-
SMMC7721 MnnqR5l1d3SxeHnjbZR6KGG|c3H5 MWi3NkBpenN? MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT63PEDPxE1w MkjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyN{exPFIoRjJ2MEe3NVgzRC:jPh?=
EC109 M17Db2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIC5UHE4OiCqcoO= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwNkGg{txONg>? M1rjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEe3NVgzLz5{NEC3O|E5OjxxYU6=
PC3 M1rRXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYPTfHppPzJiaILz NE\KUWpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2Lke2JO69VS5? NIe4RYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC3O|E5Oid-MkSwO|cyQDJ:L3G+
HCT8 MnPlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEigZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk46OiEQvF2u NEHuPIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVA6PCd-MkSwPVUxQTR:L3G+
Bel7402 NHi4b3VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoKwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDhwMzFOwG0v NFzTfms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVA6PCd-MkSwPVUxQTR:L3G+
A549 Mn;RRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFPsSIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC57MjFOwG0v M2f1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NFk1Lz5{NEC5OVA6PDxxYU6=
SKOV3 NELRNJpEgXSxdH;4bYNqfHliYYPzZZk> M{e3RlMh\GG7cx?= MkPqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjR|IN88UU4> MlnaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OFUoRjJ2MEm1O|Q2RC:jPh?=
HepG2 MlrCR5l1d3SxeHnjbZR6KGG|c3H5 Ml7vN{Bl[Xm| MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlkvQThizszNMi=> NHXFO2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc1PSd-MkSwPVU4PDV:L3G+
A549 NYe1ZYhPS3m2b4TvfIlkcXS7IHHzd4F6 NFnie4o{KGSjeYO= NHjje2NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUA{PC5|MzFOwG0v NI\4WHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc1PSd-MkSwPVU4PDV:L3G+
NCI-H460 NWTYT5pJS3m2b4TvfIlkcXS7IHHzd4F6 MnK0N{Bl[Xm| MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDRwMESg{txONg>? NYnmcJlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PDVpPkK0NFk2PzR3PD;hQi=>
MGC803 MWjDfZRwfG:6aXPpeJkh[XO|YYm= MmHLOFghcHK| M{POdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy54ODFOwG0v M4juUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5PFY6Lz5{NEGxPVg3QTxxYU6=
HepG2 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MWC0PEBpenN? M1Hye2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1NjN3IN88UU4> NEXEe4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVg3QSd-MkSxNVk5Pjl:L3G+
Bcap37 NGjRSXZEgXSxdH;4bYNqfHliYYPzZZk> NXHseXV4PDhiaILz MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFUvPThizszNMi=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzOUi2PUc,OjRzMUm4Olk9N2F-
SGC7901 M2HQOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXW4ZZNnPDhiaILz M2TiSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwM{eg{txONg>? MlmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUm4OlkoRjJ2MUG5PFY6RC:jPh?=
DU145 NYjBXm92S3m2b4TvfIlkcXS7IHHzd4F6 NWrZWHF4S3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMtKEmFNUCgQUA{NjRizszNMi=> Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOUW0OlYoRjJ2MUm1OFY3RC:jPh?=
NCI-H460 MXXDfZRwfG:6aXPpeJkh[XO|YYm= MlnRR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMtKEmFNUCgQUA5NjVizszNMi=> M1HSSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUm1OFY3Lz5{NEG5OVQ3PjxxYU6=
HCT116 M1vvbmN6fG:2b4jpZ4l1gSCjc4PhfS=> M37QUVczKGi{cx?= M3rGWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC5|MjFOwG0v MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJzMUCyNUc,OjR{MUGwNlE9N2F-
MGC803 MnHER5l1d3SxeHnjbZR6KGG|c3H5 NXq4RmVMPzJiaILz M1\ubGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTVwM{Kg{txONg>? NVfsdJdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVExOjFpPkK0NlEyODJzPD;hQi=>
HepG2 Mo[3R5l1d3SxeHnjbZR6KGG|c3H5 MoXNO|IhcHK| M1fwVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQS52NTFOwG0v NW\P[XRWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVExOjFpPkK0NlEyODJzPD;hQi=>
A549 MXHDfZRwfG:6aXPpeJkh[XO|YYm= MlPNO|IhcHK| NEXST5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC5zMzFOwG0v NFvzTm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKxNVAzOSd-MkSyNVExOjF:L3G+
NCI-H460 M2LPbWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUm3NkBpenN? NIryb|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuN|Ih|ryPLh?= NF;LZoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKxNVAzOSd-MkSyNVExOjF:L3G+
SW1116 NGHrVIJEgXSxdH;4bYNqfHliYYPzZZk> MXS0PEBpenN? NESwV4JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzFzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwMk[g{txONg>? M33rWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mki2O|YyLz5{NEK4Olc3OTxxYU6=
HepG2 NITpRmdEgXSxdH;4bYNqfHliYYPzZZk> MYm0PEBpenN? MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{41OyEQvF2u NIm2S2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4Olc3OSd-MkSyPFY4PjF:L3G+
BGC823 NV[0WmhFS3m2b4TvfIlkcXS7IHHzd4F6 MmfJOFghcHK| MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvPDhizszNMi=> NFO5SWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4Olc3OSd-MkSyPFY4PjF:L3G+
MCF7 MkjYR5l1d3SxeHnjbZR6KGG|c3H5 NXTrUGE1PDhiaILz MlrrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPU44QSEQvF2u NWLqR3lSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFY4PjFpPkK0Nlg3PzZzPD;hQi=>
MCF7 NFWxZ|BEgXSxdH;4bYNqfHliYYPzZZk> MmTwOFghcHK| MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlUh|ryPLh?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN|MkS5O{c,OjR|M{K0PVc9N2F-
B16 NIDhXotEgXSxdH;4bYNqfHliYYPzZZk> M{W0SFQ5KGi{cx?= M{LxSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGIyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE4zKM7:TT6= M2\xOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{OyOFk4Lz5{NEOzNlQ6PzxxYU6=
ME180 NGfxU3lEgXSxdH;4bYNqfHliYYPzZZk> NFjmO401QCCqcoO= NWXRSXZzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUVzOECgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwOTFOwG0v NGTpV5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOzNlQ6Pyd-MkSzN|I1QTd:L3G+
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Bel7402 NHrYRopEgXSxdH;4bYNqfHliYYPzZZk> NGq0SJI1KGSjeYO= M2\JeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJmdDd2MEKgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNTFOwG0v NEDycoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVMxOyd-MkSzOVk{ODN:L3G+
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HCT116 NX6wU|BQS3m2b4TvfIlkcXS7IHHzd4F6 NGn1RoI4OiCqcoO= NFfqU4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDBwNTFOwG0v MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4NkK4Nkc,OjVyNk[yPFI9N2F-
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MGC803 MUPDfZRwfG:6aXPpeJkh[XO|YYm= MXS0PEBpenN? NH\Z[lREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwN{Gg{txONg>? NX75RVJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OVQ6OjJpPkK1OVU1QTJ{PD;hQi=>
Bcap37 NF3meIJEgXSxdH;4bYNqfHliYYPzZZk> MUO0PEBpenN? NGnET4lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD[2GyM{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwMUig{txONg>? MnnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NUS5NlIoRjJ3NUW0PVIzRC:jPh?=
SGC7901 NYnMc|lrS3m2b4TvfIlkcXS7IHHzd4F6 MWq0PEBpenN? M1TJe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwNU[g{txONg>? NX\td2FqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OVQ6OjJpPkK1OVU1QTJ{PD;hQi=>
BALB/3T3 NXPXcIlMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MW[3NkBpenN? NHLKZ2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBUGIwO1R|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCVUlKgcYV1cG:mLDDJR|UxKD1iMz6yN{DPxE1w MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
LoVo MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWm3NkBpenN? NGPrVFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzvWo8h[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUCgQUA1NjZ7IN88UU4> Mkj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
doxorubicin-resistant LoVo/DX NWnRWo86SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkHSO|IhcHK| NUm1ZppFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhVG:Ybz;EXEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFYh|ryPLh?= NWrYOoU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
SW707 NHuweJlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NH;TV|M4OiCqcoO= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZN{C3JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gNlAvPDZizszNMi=> NIDCS|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
vincristine-resistant HL60/Vinc NUfRXHBSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlzGO|IhcHK| MlfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiC4aX7jdol{fGmwZT3y[ZNqe3SjboSgTGw3OC:YaX7jJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU4yPSEQvF2u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
HL60 M2LtZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF\BTmw4OiCqcoO= MoTJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNk42PCEQvF2u M2fWclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
HT-29 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV[3NkBpenN? MlS1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFI2NjB6IN88UU4> NVzlS5FPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
LS180 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXzzU|d5PzJiaILz NXLYfoJYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMV|E5OCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIH3leIhw\CxiSVO1NEA:KDN6LkmyJO69VS5? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
B16F10 M3v2VWFvfGmlYX7j[ZIh[XO|YYm= NGWwO4M4OiCqcoO= NIXMe3JCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3TjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT60N{DPxE1w NELMOWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
MGC803 M3LQeWFvfGmlYX7j[ZIh[XO|YYm= MkezO|IhcHK| M{\OV2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkSzJO69VS5? NF;PbXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
MCF7 MWLBcpRq[2GwY3XyJIF{e2G7 MmrMO|IhcHK| M1rKd2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5zMjFOwG0v M3HaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW1O|E5Lz5{NU[1OVcyQDxxYU6=
EC109 M3zxNGFvfGmlYX7j[ZIh[XO|YYm= NYLRWJlJPzJiaILz NF[2eG5CdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSWMyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMT62NUDPxE1w MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3NUexPEc,OjV4NUW3NVg9N2F-
HCT8 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{HLOFczKGi{cx?= NVywZlR{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3Q5KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlkyKM7:TT6= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ5NUG0OEc,OjV4N{WxOFQ9N2F-
HCT8 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX72W5pqPzJiaILz NFTlSIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JFUuTlVicnXzbZN1[W62IHj1cYFvKEiFVEigZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN4Lk[zPEDPxE1w NIPNPFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[3OVE1PCd-MkW2O|UyPDR:L3G+
MGC803 NWPheJh4S3m2b4TvfIlkcXS7IHHzd4F6 M1HTUlczKGi{cx?= NULmZZU1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD63NkDPxE1w MnqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEewNVIoRjJ3N{C3NFEzRC:jPh?=
MCF7 NWry[5ppS3m2b4TvfIlkcXS7IHHzd4F6 NFK1TYY4OiCqcoO= NHfxTmlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi5{NDFOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdyN{CxNkc,OjV5MEewNVI9N2F-
EC9706 NEHF[FNEgXSxdH;4bYNqfHliYYPzZZk> NGnFSnI4OiCqcoO= MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFR|k4ODZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjZ5IN88UU4> M{[wZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{C3NFEzLz5{NUewO|AyOjxxYU6=
SMMC7721 NXTmboRHS3m2b4TvfIlkcXS7IHHzd4F6 NYf1WHpyPzJiaILz MkWzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJyLkSg{txONg>? M4SwNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{C3NFEzLz5{NUewO|AyOjxxYU6=
SW1573 NEm4XYlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkS3OFghcHK| MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZMUW3N{Bk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFQvOyEQvF2u M37TXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{WyOVI2Lz5{NUe1NlUzPTxxYU6=
HBL100 MoXiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXO0PEBpenN? NY\Z[4Q{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIRmwyODBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSB3LkWg{txONg>? M{O0UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{WyOVI2Lz5{NUe1NlUzPTxxYU6=
HeLa NUnzbHpOSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGH0O|k1QCCqcoO= MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCxOUDPxE1w M1nMSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{WyOVI2Lz5{NUe1NlUzPTxxYU6=
T47D MnnLRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mlm1OFghcHK| NGnwS4NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS0O2Qh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUA1PyEQvF2u M4jOTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{WyOVI2Lz5{NUe1NlUzPTxxYU6=
WiDr MlXZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUC0PEBpenN? NI\sO|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGfpSJIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUA1QSEQvF2u NV\rb2JiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVI2OjVpPkK1O|UzPTJ3PD;hQi=>
MGC803 M3TDZ2FvfGmlYX7j[ZIh[XO|YYm= M2m5VlQ5KGi{cx?= NVnMSIxXSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjV6IN88UU4> MnWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUK5OlYoRjJ3OEGyPVY3RC:jPh?=
SMMC7721 M2PNNWFvfGmlYX7j[ZIh[XO|YYm= M2njSVQ5KGi{cx?= NY\zWYFoSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHNOVUN5N{KxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxic4Xyeol3[WxiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwOEeg{txONg>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzMkm2Okc,OjV6MUK5OlY9N2F-
HepG2 MYPBcpRq[2GwY3XyJIF{e2G7 M2TmV|Q5KGi{cx?= NHTWfpBCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU45PiEQvF2u Mn;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUK5OlYoRjJ3OEGyPVY3RC:jPh?=
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SKOV3 Mn;LR5l1d3SxeHnjbZR6KGG|c3H5 M4K5c|Ih\GG7cx?= NWXrUWZyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5LkO0JO69VS5? NX7YfoRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTZpPkK1PFQyOTl4PD;hQi=>
HepG2 Mo\jR5l1d3SxeHnjbZR6KGG|c3H5 MonLNkBl[Xm| MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|EvQThizszNMi=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2MUG5Okc,OjV6NEGxPVY9N2F-
A549 M{L0dGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3\rfFIh\GG7cx?= NGPWSpNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFIh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUA{QC5{MzFOwG0v NVrZcXRrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFEyQTZpPkK1PFQyOTl4PD;hQi=>
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A549 Mn;PR5l1d3SxeHnjbZR6KGG|c3H5 MXm0PEBpenN? MlexR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|YvOzRizszNMi=> M4T1e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OESxNVk6Lz5{NUi0NVE6QTxxYU6=
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MDA-MB-231 NXmxW25pS3m2b4TvfIlkcXS7IHHzd4F6 Mn63OFghcHK| M1[0cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuPFIh|ryPLh?= Ml7kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{CxN|EoRjJ3OEewNVMyRC:jPh?=
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MDA-MB-231 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnvhO|IhcHK| NWXZNYJNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iNT6yJO69VS5? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTlzOUC1Nkc,OjV7MUmwOVI9N2F-
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HepG2 MmntR5l1d3SxeHnjbZR6KGG|c3H5 NV7JbJVxOiCmYYnz MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBqdmO3YnH0[YQh\m:{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NE4{PCEQvF2u NVPVSVQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVk5ODJpPkK2NlU6QDB{PD;hQi=>
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MCF7 M4r2e2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYS0PEBpenN? MkfNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFIvPzhizszNMi=> Ml7WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OEOxOFgoRjJ4OEizNVQ5RC:jPh?=
Bcap37 M17IRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHOfWRMPDhiaILz MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ4NjB7IN88UU4> Mn3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OEOxOFgoRjJ4OEizNVQ5RC:jPh?=
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HL60 M1PSfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEXUeoo4OiCqcoO= MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5LkSzJO69VS5? NYLyb49ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlIzOjNpPkK2PVIzOjJ|PD;hQi=>
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HepG2 MlLlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3WwUFczKGi{cx?= NUP4b2Z5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFkvODJizszNMi=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKyN{c,OjZ7MkKyNlM9N2F-
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HT-29 Mn7wRY51cWOjbnPldkBie3OjeR?= M4nQXlQ5KGi{cx?= M175VGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPSEQvF2u M3LKTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKyNlM{Lz5{NkmyNlI{OzxxYU6=
HCT116 NH;COFFCdnSrY3HuZ4VzKGG|c3H5 NHfEeXM4OiCqcoO= M1m1XWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwODFOwG0v M1y1fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKyNlM{Lz5{NkmyNlI{OzxxYU6=
RKO MnfHRY51cWOjbnPldkBie3OjeR?= MUO0PEBpenN? MoLoRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLLU{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NU4yKM7:TT6= MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkKyN|MoRjJ4OUKyNlM{RC:jPh?=
KB NH\C[YxEgXSxdH;4bYNqfHliYYPzZZk> NXnBTnRuPzJiaILz M3KwRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC0Mlg1KM7:TT6= M3LGRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
HeLa NX2yXmZXS3m2b4TvfIlkcXS7IHHzd4F6 NEnDOm04OiCqcoO= M4\oTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFYvOjNizszNMi=> MoWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
MCF7 NV3OXJdCS3m2b4TvfIlkcXS7IHHzd4F6 Mmm5O|IhcHK| MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IE[uOVMh|ryPLh?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
HepG2 NXjaO|lES3m2b4TvfIlkcXS7IHHzd4F6 NG\pe5I4OiCqcoO= Mo\hR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFYvPiEQvF2u NXLTTm1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
HDF NGnBUllEgXSxdH;4bYNqfHliYYPzZZk> M{LjVFczKGi{cx?= NFP5bZlEgXSxdH;4bYNqfHliYXfhbY5{fCCKRF[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDdwMEKg{txONg>? M13VTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
143B M4W2fGN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7CO|IhcHK| MlK5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVQ{SiClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVMvODFizszNMi=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5M{C1OUc,OjdyN{OwOVU9N2F-
thymidine kinase deficient 143B MlfGR5l1d3SxeHnjbZR6KGG|c3H5 M1q0SlczKGi{cx?= MkD5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6geIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgNVQ{SiClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVYvOzFizszNMi=> MlLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
U87MG NVXNfmd2S3m2b4TvfIlkcXS7IHHzd4F6 M17xOFczKGi{cx?= NFT3e2ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDePRzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IGqyJINwfWy2ZYKgZ492dnSncjDt[ZRpd2RuIFnDOVAhRSBzOD6yOUDPxE1w MoL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOEG3OFIoRjJ5MEixO|QzRC:jPh?=
PC3 M4WwO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2fwSFQ5KGi{cx?= M4mwVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Lke2JO69VS5? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
HT-29 NEjicWpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MV:0PEBpenN? NH\QWHNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlgh|ryPLh?= M3vBbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
U87MG M3uwbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{nxXlQ5KGi{cx?= NXzHXZE6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{43PSEQvF2u NWGzSFE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
A549 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX;O[VZjPDhiaILz NXLJNphESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlk5KM7:TT6= M3TWeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
HaCaT NYHPdmxoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFvM[Vk1QCCqcoO= NXjGc5A4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIZWNiXCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvOTVizszNMi=> NIL1e2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C5NlQyOyd-MkewPVI1OTN:L3G+
MGC803 NEjXTmRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWHlSVNVPzJiaILz MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkK1JO69VS5? MoPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
EC109 MluzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXq3NkBpenN? M2DP[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRVOxNFkh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz6xO{DPxE1w NHrPdpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
SH-SY5Y MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYG3NkBpenN? MojzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNlYh|ryPLh?= NFzFbFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
U87 NWT6WVdtSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHHQcFM4OiCqcoO= MoTMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MTFOwG0v NEnxdG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
MCF7 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NIfEOXk4OiCqcoO= MoC3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwNkGg{txONg>? M2W2UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
MDA-MB-231 NFPVV3lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVy0PEBpenN? NFPwWJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2Lk[g{txONg>? M{mzPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
MCF7 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV20PEBpenN? NHPlOYdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOwMlQyKM7:TT6= NVmwVYxRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyQDBpPkK3NVI5OThyPD;hQi=>
A549 NF3xNWlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUS0PEBpenN? M3XUPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuOFEh|ryPLh?= NFz0UXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE5OCd-MkexNlgyQDB:L3G+
HepG2 MmD5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NF;YWGc1QCCqcoO= Mnf5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNE[uPFMh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG4NEc,OjdzMkixPFA9N2F-
MCF7 MXzDfZRwfG:6aXPpeJkh[XO|YYm= NXrOSlNpPDhiaILz M37kbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjVizszNMi=> NFKzSXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
Bcap37 NH;0eY5EgXSxdH;4bYNqfHliYYPzZZk> MnjIOFghcHK| NFfRc3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD[2GyM{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkS3JO69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
Hep3B NVm4fJRGS3m2b4TvfIlkcXS7IHHzd4F6 M2roNlQ5KGi{cx?= M3fNVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy53MzFOwG0v NHO2eWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
A549 NUfuOnJ4S3m2b4TvfIlkcXS7IHHzd4F6 MXG0PEBpenN? MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU42QCEQvF2u MlSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
U251 NFnNeWREgXSxdH;4bYNqfHliYYPzZZk> NV35dmFJPDhiaILz NGPKS2VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC54OTFOwG0v NXHKboFHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexN|M2QTNpPkK3NVM{PTl|PD;hQi=>
HepG2 MnjRR5l1d3SxeHnjbZR6KGG|c3H5 M3q4dVQ5KGi{cx?= NXnuPGJTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ3LkG3JO69VS5? M1rEcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
LNCAP NIPwSYZEgXSxdH;4bYNqfHliYYPzZZk> MmfqNlQhcHK| NWC3ZVlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMkSgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> NW\lcIhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOVY4PzBpPkK3NVU3PzdyPD;hQi=>
PC3 M1HmZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3zDblI1KGi{cx?= Mn\jR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFI1KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w NEHCelg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G1Olc4OCd-MkexOVY4PzB:L3G+
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LNCAP NUfDNXhiS3m2b4TvfIlkcXS7IHHzd4F6 M4i3V|Q5KGi{cx?= MnXtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR5LkG4JO69VS5? MkDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd{MUC0N|goRjJ5MkGwOFM5RC:jPh?=
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HepG2 Mlr2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{\GblQ5KGi{cx?= NUPhU5BZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NUDHO24xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFc{PjhpPkK3Nlg4OzZ6PD;hQi=>
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A549 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MVG3NkBpenN? NFm5NFdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA3NjhizszNMi=> NGnjeVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
SGC7901 NF;MSVJEgXSxdH;4bYNqfHliYYPzZZk> M2jzWFczKGi{cx?= MmXUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwOTFOwG0v NHnWfok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
MDA-MB-435S NHnDfnFEgXSxdH;4bYNqfHliYYPzZZk> M{HWZ|czKGi{cx?= NW\rNYZ5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PVNiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjJizszNMi=> NELRZ2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
PC3 NELOPVVEgXSxdH;4bYNqfHliYYPzZZk> M1ntc|czKGi{cx?= NYHFR3pXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1Oi53IN88UU4> NVjqUmZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1N|c6OjRpPkK3OVM4QTJ2PD;hQi=>
colon cancer cell MnPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUW0PEBpenN? NUnmVHNmT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h[2:ub36gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA5NjRizszNMi=> MorCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUS0OFQoRjJ5NUW0OFQ1RC:jPh?=
leukemia cell M{TES2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIW4[2k1QCCqcoO= MkTkS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDF3LkGg{txONg>? NGTmTFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W1OFQ1PCd-Mke1OVQ1PDR:L3G+
prostate cancer cell NESxdIdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHXVeos1QCCqcoO= MmDUS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAzOi55IN88UU4> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV3NES0OEc,Ojd3NUS0OFQ9N2F-
renal cancer cell M2X5RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU[0PEBpenN? MlrSS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTC0OU43KM7:TT6= Ml7ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUS0OFQoRjJ5NUW0OFQ1RC:jPh?=
DU145 NFnHS49EgXSxdH;4bYNqfHliYYPzZZk> M3HROVQ5KGi{cx?= M2LzdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uNUDPxE1w MoqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVgoRjJ5NU[xO|E5RC:jPh?=
HeLa MlrMR5l1d3SxeHnjbZR6KGG|c3H5 NFfJNIk1QCCqcoO= NU[4VZZVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK4MlIh|ryPLh?= NVPXcYhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
IOSE-144 NULUWZd7S3m2b4TvfIlkcXS7IHHzd4F6 MmPWOFghcHK| M{j6NGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGlQW0VvMUS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|YvOSEQvF2u M37pblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E5Lz5{N{W2NVcyQDxxYU6=
HepG2 NUDRXG13S3m2b4TvfIlkcXS7IHHzd4F6 NUGx[2gzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlMh|ryPLh?= NWjnNYlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OTlpPkK3OVYyPzF7PD;hQi=>
DU145 MnroR5l1d3SxeHnjbZR6KGG|c3H5 M2LKNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT62JO69VS5? NVnKTXlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OTlpPkK3OVYyPzF7PD;hQi=>
MDA-MB-231 NH7LfJNEgXSxdH;4bYNqfHliYYPzZZk> M4PXdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjhizszNMi=> MnK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVkoRjJ5NU[xO|E6RC:jPh?=
HeLa MYXDfZRwfG:6aXPpeJkh[XO|YYm= NG\GUlBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT65JO69VS5? MlS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVkoRjJ5NU[xO|E6RC:jPh?=
SW780 M3m4SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlS1O|IhcHK| MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTW|c5OCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDZwOUmg{txONg>? M1zvUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
MGC803 M4TYU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHroZ4U4OiCqcoO= NXzjWVZlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gNVAvPjRizszNMi=> MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
HL-7702 NYPpclJ2S3m2b4TvfIlkcXS7IHHzd4F6 MlH6O|IhcHK| MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUE04PzB{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUKuPFUh|ryPLh?= M1PndVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
MCF7 M1XtVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2f6O|czKGi{cx?= NXe2dXo1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IEGzMlE6KM7:TT6= M{LjRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
GES-1 MYTDfZRwfG:6aXPpeJkh[XO|YYm= NVHsbndxPzJiaILz M2jRU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdGWy1zIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUOuO|Uh|ryPLh?= NXe0NGxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
TE1 M2TaOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnXVO|IhcHK| MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUSVEh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUzhiYYPzZZktKEmFNUCgQUAyPy5|MjFOwG0v MnjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
A549 NV\6dIlYS3m2b4TvfIlkcXS7IHHzd4F6 NIfheXA1QCCqcoO= NY\IS4M6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OC52NzFOwG0v NXT0PI1uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
MDA-MB-231 MnHpR5l1d3SxeHnjbZR6KGG|c3H5 NHHnNZE1QCCqcoO= MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN3Lkm4JO69VS5? Mo\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4MUS0NFgoRjJ5NkG0OFA5RC:jPh?=
DU145 NETKSmJEgXSxdH;4bYNqfHliYYPzZZk> MVe0PEBpenN? NGSxS5lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OC53ODFOwG0v NUK2fGNWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
PC3 MnrMR5l1d3SxeHnjbZR6KGG|c3H5 NXHlOpdkPDhiaILz MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEWuN|Ih|ryPLh?= NIK5e4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQxQCd-Mke2NVQ1ODh:L3G+
MCF7 NUnNTlRLS3m2b4TvfIlkcXS7IHHzd4F6 NYDtVWRrPDhiaILz MmTYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwJF0hPC53IN88UU4> NV;heYRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQDRpPkK3Olg5OTh2PD;hQi=>
HepG2 NH3JcIdHfW6ldHnvckBie3OjeR?= MVy0PEBpenN? NXXlSXRGUGWyYYTveI95cWOrdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBIUTVyIE2gO{DPxE1w M3jIelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVg1Lz5{N{[4PFE5PDxxYU6=
U87 NEPmdGNHfW6ldHnvckBie3OjeR?= NYDk[mRvPDhiaILz M1n5c25mfXKxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NEA:KDF|IN88UU4> NEPnVpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE5PCd-Mke2PFgyQDR:L3G+
HCT116 NYGyVW5zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFv2c4g4OiCqcoO= NXO1Voh2T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB{LkWg{txONg>? M3e5PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{C0PFEyLz5{N{ewOFgyOTxxYU6=
HeLa NH\scFZEgXSxdH;4bYNqfHliYYPzZZk> MnHvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNjFOwG0v MnXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkCyPVYoRjJ5N{KwNlk3RC:jPh?=
PC3 NIjrUWhEgXSxdH;4bYNqfHliYYPzZZk> M2\pUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NU\LV3o6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NlAzQTZpPkK3O|IxOjl4PD;hQi=>
HepG2 NHS4O|JEgXSxdH;4bYNqfHliYYPzZZk> NXH1dXZbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlgh|ryPLh?= NU\aeotJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NlAzQTZpPkK3O|IxOjl4PD;hQi=>
MDA-MB-231 Mn:3R5l1d3SxeHnjbZR6KGG|c3H5 MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNU46KM7:TT6= Ml:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkCyPVYoRjJ5N{KwNlk3RC:jPh?=
L1210 MkPxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MW[0PEBpenN? MkDLRY51cS2ycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEmFNUCgQUAxNjN|IN88UU4> MknoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
HeLa NF[4OI1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MorOOEBl[Xm| MUPBcpRqNXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IH3lZZN2emWmIHHmeIVzKDRiZHH5d{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE42PCEQvF2u MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
CEM NYq3bm5jSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXK3NkBpenN? NHHF[XJCdnSrLYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDSW0h[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEmFNUCgQUAyQCEQvF2u M4Pob|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
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MGC803 NX24WI17S3m2b4TvfIlkcXS7IHHzd4F6 Mom5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjF2IN88UU4> Mnn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|QoRjJ5N{[5NFM1RC:jPh?=
A549 NWDSSHVOS3m2b4TvfIlkcXS7IHHzd4F6 M4rzU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvQTVizszNMi=> M{TtTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{[5NFM1Lz5{N{e2PVA{PDxxYU6=
EC109 NUfiRZpKS3m2b4TvfIlkcXS7IHHzd4F6 MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU46QSEQvF2u MlTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|QoRjJ5N{[5NFM1RC:jPh?=
MGC803 MoXrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NE\qWm04OiCqcoO= NFXJZWNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4{PSEQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5MUW5PUc,Ojd5N{G1PVk9N2F-
MCF7 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlrOO|IhcHK| NVnxb5duSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlI2KM7:TT6= M{nnb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{exOVk6Lz5{N{e3NVU6QTxxYU6=
EC109 NWDIfmdGSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{\WWlczKGi{cx?= NXnseXlLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPTlizszNMi=> NGrTSZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3NVU6QSd-Mke3O|E2QTl:L3G+
HUCCA MXTDfZRwfG:6aXPpeJkh[XO|YYm= MVSyOEBpenN? NIfFWYJEgXSxdH;4bYNqfHliYXfhbY5{fCCKVVPDRUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvPCEQvF2u NVGyS3FiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4NlU4PjNpPkK3PFI2PzZ|PD;hQi=>
QBC939 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NFzrNJMzPCCqcoO= NEXnUGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBSSkN7M{mgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlEh|ryPLh?= Mnf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MkW3OlMoRjJ5OEK1O|Y{RC:jPh?=
SW620 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYe3NkBpenN? NVfaNJF6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xQCEQvF2u M4jZS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
CFPAC-1 NXq3So1HSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYW3NkBpenN? NEDvV3VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPGVGFENTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTRizszNMi=> NHrEOFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
WI38 NEOyN2dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkLPO|IhcHK| MnLBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZSUO4JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkm0JO69VS5? NYjCSItIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
A549 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHztTYo4OiCqcoO= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwODFOwG0v M{Xhc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
HeLa MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{\ITlczKGi{cx?= M4TMPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD64NUDPxE1w NV3xe3luRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
HepG2 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3zoeVczKGi{cx?= Ml3LRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD65JO69VS5? NIjCfnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
Hep3B NEjrfFNEgXSxdH;4bYNqfHliYYPzZZk> MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwM{[g{txONg>? M37NelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUGzNVc6Lz5{N{mxN|E4QTxxYU6=
A549 MlX6R5l1d3SxeHnjbZR6KGG|c3H5 MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwNkOg{txONg>? NVvjVI9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NVMyPzlpPkK3PVE{OTd7PD;hQi=>
WISH M{G2c2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVGyOEBpenN? NWTDfJNxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX0mVSDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNUDPxE1w MmHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NUG0PFcoRjJ5OUWxOFg4RC:jPh?=
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A549 NHvMOHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MW[3NkBpenN? NHnHNIpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNVYh|ryPLh?= NVPnbpIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFc1QDVpPkK3PVg4PDh3PD;hQi=>
MDA-MB-231 NILLO3VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX:3NkBpenN? NETmfXdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVizszNMi=> NFnBOHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m4O|Q5PSd-Mke5PFc1QDV:L3G+
HepG2 M3\zS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4raeVczKGi{cx?= M2\wOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWg{txONg>? M3jOdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUi3OFg2Lz5{N{m4O|Q5PTxxYU6=
MCF7 NEjjcpJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4rueVczKGi{cx?= MkjaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkGyJO69VS5? MmfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEe0PFUoRjJ5OUi3OFg2RC:jPh?=
Hep3B NXu2cG1sS3m2b4TvfIlkcXS7IHHzd4F6 MkO0OFghcHK| NUCwWllOS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkWzJO69VS5? NHO0N5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5N|UyPid-Mke5PVM2OTZ:L3G+
HepG2 NWnPWWpvS3m2b4TvfIlkcXS7IHHzd4F6 MVq0PEBpenN? M4PTSGN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Oi54IN88UU4> MnzlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUO1NVYoRjJ5OUmzOVE3RC:jPh?=
HepG2 MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkLoNlQhcHK| NFXLO5VIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzJwOEeg{txONg>? NGG2cm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOCd-MkiwNVEzOjB:L3G+
PA1 M4TFcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFnIVnczPCCqcoO= NF7wXZNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSTFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM6NjVizszNMi=> NGjpeYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOCd-MkiwNVEzOjB:L3G+
HCT15 NV3mOW5ST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGjuZ2IzPCCqcoO= NVPzdHdzT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR3LkCxJO69VS5? NX7C[XM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNVEzOjBpPkK4NFEyOjJyPD;hQi=>
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SKOV3 MkL4R5l1d3SxeHnjbZR6KGG|c3H5 MmrJO|IhcHK| M2G5emN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLU3Y{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOjNwMUGg{txONg>? M2jZOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEGxNlI{Lz5{OECxNVIzOzxxYU6=
A549 MX\DfZRwfG:6aXPpeJkh[XO|YYm= M2LpbVczKGi{cx?= M3;xcGN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA{Oi5zNTFOwG0v MkK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyMUGyNlMoRjJ6MEGxNlI{RC:jPh?=
HepG2 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M4\4clQ5KGi{cx?= NGO5bGNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCClb3zvdolu\XS{aXOgZZN{[XluIFnDOVAhRSBzMD6xO{DPxE1w MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
Hep3B NX3pTIt[S3m2b4TvfIlkcXS7IHHzd4F6 M2T6TFQ5KGi{cx?= MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBkd2yxcnnt[ZRzcWNiYYPzZZktKEmFNUCgQUAyOC53MzFOwG0v MoHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlcoRjJ6MEO4N|I4RC:jPh?=
A549 NF\NWmFEgXSxdH;4bYNqfHliYYPzZZk> NHLCUJg1QCCqcoO= NHTufmpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDN2LkK3JO69VS5? NYi1OlBXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjdpPkK4NFM5OzJ5PD;hQi=>
MCF7 NGLhUZhEgXSxdH;4bYNqfHliYYPzZZk> M1XXO|Q5KGi{cx?= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJINwdG:{aX3leJJq[yCjc4PhfUwhUUN3MDC9JFQzNjd6IN88UU4> NUOxVIx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjdpPkK4NFM5OzJ5PD;hQi=>
Bcap37 NGfGZWVEgXSxdH;4bYNqfHliYYPzZZk> MonVOFghcHK| MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[2:ub4LpcYV1emmlIHHzd4F6NCCLQ{WwJF0hPDdwMTFOwG0v M3zFXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N|I4Lz5{OECzPFMzPzxxYU6=
U251 MUnDfZRwfG:6aXPpeJkh[XO|YYm= NG\Lc241QCCqcoO= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVNlUyKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJINwdG:{aX3leJJq[yCjc4PhfUwhUUN3MDC9JFQ5NjZ6IN88UU4> NFzaclQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzPyd-MkiwN|g{Ojd:L3G+
MGC803 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MXe0PEBpenN? MmXFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNlEh|ryPLh?= NYjtZWVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjlpPkK4NFM5OzJ7PD;hQi=>
EC109 NXrhblJsS3m2b4TvfIlkcXS7IHHzd4F6 M3nofFQ5KGi{cx?= NH;RdWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGSzFyOTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4{KM7:TT6= M{LiXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N|I6Lz5{OECzPFMzQTxxYU6=
PC3 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NIrWc4s1QCCqcoO= NWHPWYJCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlMyKM7:TT6= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyPUc,OjhyM{izNlk9N2F-
A549 NWnafndDSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3XFSVQ5KGi{cx?= MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkWg{txONg>? NUTFOlBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwO|M3PzZpPkK4NFc{Pjd4PD;hQi=>
MCF7 NFviSFZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3H5[lQ5KGi{cx?= Mn3CRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOT6yJO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB5M{[3Okc,OjhyN{O2O|Y9N2F-
HCT116 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Ml7COFghcHK| MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNkDPxE1w MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB5M{[3Okc,OjhyN{O2O|Y9N2F-
BGC823 M3myZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWK0PEBpenN? NWO4V4J1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM1NjhizszNMi=> M4XRb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEezOlc3Lz5{OEC3N|Y4PjxxYU6=
IOSE-144 Ml;hRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGHhXIY1QCCqcoO= NGXHN3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnPV2UuOTR2IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{QC5zIN88UU4> M3;RcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEezOlc3Lz5{OEC3N|Y4PjxxYU6=
MCF7 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{TLUVQ5KGi{cx?= MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4LkG0JO69VS5? Mm\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUC4O|EoRjJ6MUGwPFcyRC:jPh?=
HCT116 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NW\SdpE4PDhiaILz M1HrTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPE4{KM7:TT6= NFvpV249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxNFg4OSd-MkixNVA5PzF:L3G+
PANC1 MljWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXPscXVJPDhiaILz MkDxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQV7DNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEeuPFMh|ryPLh?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzMEi3NUc,OjhzMUC4O|E9N2F-
HepG2 Ml3mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXrxcHFvPDhiaILz NV3aUox4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFkvODJizszNMi=> NXPNfGU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVA5PzFpPkK4NVExQDdzPD;hQi=>
BCG823 MYPDfZRwfG:6aXPpeJkh[XO|YYm= M4XLTVQ5KGi{cx?= MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCR2c5OjNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD6xJO69VS5? NX62R2xuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVczODJpPkK4NVE4OjB{PD;hQi=>
A549 M2XOeGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUnRSZpoPDhiaILz NVq1eZc{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlEh|ryPLh?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzN{KwNkc,OjhzMUeyNFI9N2F-
HepG2 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NV;kc|Q2PDhiaILz NYHsWmZRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxO{4zKM7:TT6= MkTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUeyNFIoRjJ6MUG3NlAzRC:jPh?=
EC9706 M{\aSWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYDQWGZRPDhiaILz NFLzeo9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXDPVcxPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvOjZizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzOUKwNEc,OjhzMUmyNFA9N2F-
ECA109 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2Xvb|Q5KGi{cx?= NIjRUXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXDRVExQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|AvOjVizszNMi=> NHfjN3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxPVIxOCd-MkixNVkzODB:L3G+
K562 Mk\3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVK0PEBpenN? MkDyS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgW3NVOSCjc4PhfUwhUUN3MDC9JFM5NjV6IN88UU4> M1Tie|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK2OFM3Lz5{OEGyOlQ{PjxxYU6=
KKU-M214 NFW2ZpdEgXSxdH;4bYNqfHliYYPzZZk> NHPU[GE4OiCqcoO= NHX6So9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMU1VvTUKxOEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMvPzZizszNMi=> NEn0c3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG0NFU6Oid-MkixOFA2QTJ:L3G+
HL60 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGLhU|E1QCCqcoO= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDFwNkKg{txONg>? NUm4Um5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVI1OzBpPkK4NVUzPDNyPD;hQi=>
NCI-H1299 NVLiOlRkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NInQWoU1QCCqcoO= M{PrZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyOjl7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUA5NjlzIN88UU4> NYC1fWJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVI1OzBpPkK4NVUzPDNyPD;hQi=>
MCF7 NV7POmQ5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml3BO|IhcHK| MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwN{Wg{txONg>? MlzzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
Bel7402 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUS3NkBpenN? Mmi1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlI2KM7:TT6= NV74eJF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
MGC803 NEjq[GhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUG3NkBpenN? M{nwSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlEzKM7:TT6= NUXrRWxqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
K562 MmLoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MkPQO|IhcHK| NG\ibFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuOVQh|ryPLh?= NFnWS449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
HepG2 M3rBW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4HOXVQ5KGi{cx?= NWrM[HN2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlU{KM7:TT6= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF5NEGwO{c,OjhzN{SxNFc9N2F-
Hep3B MVfDfZRwfG:6aXPpeJkh[XO|YYm= M{K3VlQ5KGi{cx?= NFzWfGREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEmuO|Ih|ryPLh?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF5NEGwO{c,OjhzN{SxNFc9N2F-
MCF7 M1PscmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUTESXE1PzJiaILz M{TtO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDFwNDFOwG0v Mn75QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUmwOFYoRjJ6MkG5NFQ3RC:jPh?=
HCT116 NX\SNYprS3m2b4TvfIlkcXS7IHHzd4F6 NEfN[3c4OiCqcoO= M4nXN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMUiuOEDPxE1w M4PtW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG5NFQ3Lz5{OEKxPVA1PjxxYU6=
HuH7 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NFr2fmc4OiCqcoO= Mli0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOjFizszNMi=> NGPQdWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxPVA1Pid-MkiyNVkxPDZ:L3G+
A549 M{LLOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFi4flAzPCCqcoO= Mn7IR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4zKM7:TT6= NH;Mfoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HeLa NV\4cHhSS3m2b4TvfIlkcXS7IHHzd4F6 MlvaNlQhcHK| NHjZNolEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjRizszNMi=> MliyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NUS2PVcoRjJ6MkW0Olk4RC:jPh?=
HepG2 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M1XWN|I1KGi{cx?= MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ3NE[5O{c,Ojh{NUS2PVc9N2F-
COLO205 MVvDfZRwfG:6aXPpeJkh[XO|YYm= MVGyOEBpenN? NELXU4hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkmg{txONg>? NH7rS4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HepG2 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NITHcHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlEh|ryPLh?= NIDGeWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK2NlUzPyd-MkiyOlI2Ojd:L3G+
Hep3B MX3DfZRwfG:6aXPpeJkh[XO|YYm= M4jybmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOlYh|ryPLh?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ4MkWyO{c,Ojh{NkK1Nlc9N2F-
Bel7402 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2iyelczKGi{cx?= MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gOU46PCEQvF2u NXvBVXpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNFE5OTVpPkK4N|AyQDF3PD;hQi=>
LO2 MlLYRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYXQVYNxPzJiaILz MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyRMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB|Mj61OFYh|ryPLh?= M{XLTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{CxPFE2Lz5{OEOwNVgyPTxxYU6=
HCT116 NHXPZnREgXSxdH;4bYNqfHliYYPzZZk> NIfRW4REgXSxdH;4bYNqfHliaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NUDPxE1w M4XL[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O0OlU1Lz5{OEOzOFY2PDxxYU6=
MCF7 MUjDfZRwfG:6aXPpeJkh[XO|YYm= NITQfHFEgXSxdH;4bYNqfHliaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEGuOUDPxE1w NEPtdXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOzOFY2PCd-MkizN|Q3PTR:L3G+
HeLa MnLURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGHZXnk1QCCqcoO= MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMEKg{txONg>? NVnxZ2x2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOlM1PDRpPkK4N|Y{PDR2PD;hQi=>
HepG2 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NI[3dFQ1QCCqcoO= NHT0UWVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{4{OSEQvF2u NFfFUYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO2N|Q1PCd-MkizOlM1PDR:L3G+
BGC823 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnjLOFghcHK| MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKJQ{iyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuN|ch|ryPLh?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN4M{S0OEc,Ojh|NkO0OFQ9N2F-
SW1116 NVvZWW45SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{LXfFQ5KGi{cx?= NFjue2RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXNVEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVgvPTJizszNMi=> MormQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NkO0OFQoRjJ6M{[zOFQ1RC:jPh?=
Hep3B NIjDXWtEgXSxdH;4bYNqfHliYYPzZZk> M{juXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGxMlkh|ryPLh?= NIO5N4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO3NVY4Pid-MkizO|E3PzZ:L3G+
MCF7 MUnDfZRwfG:6aXPpeJkh[XO|YYm= NXPMRYVQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNEDPxE1w MlzsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|N{G2O|YoRjJ6M{exOlc3RC:jPh?=
HepG2 NVrMfpVRS3m2b4TvfIlkcXS7IHHzd4F6 MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Mj62JO69VS5? MoWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|N{G2O|YoRjJ6M{exOlc3RC:jPh?=
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A549 M2LESmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVqxZpRNPDhidH:gO|IhcHK| NYflNnlJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLk[1JO69VS5? NGXpSJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO5OVIyQCd-MkizPVUzOTh:L3G+
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HepG2 M{HMXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWHWdphFPDhidH:gO|IhcHK| M3jjemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgbY5kfWKjdHXkJIZweiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTdwNESg{txONg>? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN7NUKxPEc,Ojh|OUWyNVg9N2F-
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A549 NVrLbW16T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFHtPGQ1QCCqcoO= MWjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCyMlA6KM7:TT6= MkSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MECyN|UoRjJ6NECwNlM2RC:jPh?=
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HepG2 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NXjwXWVFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSB6LkGg{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUO0NUc,Ojh2M{GzOFE9N2F-
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MGC803 NIr3WlhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{j1dFczKGi{cx?= NEDKXY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk42PiEQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3NkCzNUc,Ojh2NU[wN|E9N2F-
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HCT116 MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXu3NkBpenN? M1XFNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyPU42KM7:TT6= NUDDbI9TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyN|I2QDNpPkK5NlMzPTh|PD;hQi=>
SGC7901 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV:3NkBpenN? MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOJQ{e5NFEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO0MlQh|ryPLh?= M1;HcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MkOyOVg{Lz5{OUKzNlU5OzxxYU6=
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HCT116 MkHxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NV3vfGl{PzJiaILz MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUGuNlkh|ryPLh?= NWTBW5ZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzNVY2OzZpPkK5N|E3PTN4PD;hQi=>
MGC803 Ml\IRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoW1O|IhcHK| M{[2b2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU42PCEQvF2u M2DlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{G2OVM3Lz5{OUOxOlU{PjxxYU6=
MGC803 MnLERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHzmOlk4OiCqcoO= NWjQSFdpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvQDZizszNMi=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m0Okc,Ojl2MEe5OFY9N2F-
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PC3 M3;LTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUXtd|VOPzJiaILz NGPDV5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkeuOlEh|ryPLh?= NV73XYl7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PDZpPkK5OFA4QTR4PD;hQi=>
HL60 Mmi5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmTSO|IhcHK| NHviPJRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|ch|ryPLh?= MmfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5PFMoRjJ7NEC3PVg{RC:jPh?=
Bel7402 NV;Be|RySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mn7GO|IhcHK| MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG4MlQ6KM7:TT6= MnvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5PFMoRjJ7NEC3PVg{RC:jPh?=
PC3 Mm\ORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHjMO2g4OiCqcoO= NVjKVpdiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKzMlg3KM7:TT6= MkPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5PFMoRjJ7NEC3PVg{RC:jPh?=
EC9706 NXT2cJBOSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXfOT5FbPzJiaILz MkLURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ{m3NFYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuNVMh|ryPLh?= MnzwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2N{WxOVYoRjJ7NEe1NVU3RC:jPh?=
EC109 MmG5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{e0VVczKGi{cx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFMUC5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4LkCyJO69VS5? NVXEemVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0O|UyPTZpPkK5OFc2OTV4PD;hQi=>
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MGC803 M4DXXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3XsVFczKGi{cx?= NHjhWpNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPU4zPCEQvF2u NHP5NIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS3OVE2Pid-Mkm0O|UyPTZ:L3G+
SMMC7721 NVL2bIpMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoWwO|IhcHK| MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOPTVO3O|IyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{44KM7:TT6= NGmwVlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS3OVE2Pid-Mkm0O|UyPTZ:L3G+
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MCF7 MofPRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NF7sdXY1QCCqcoO= MlfwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT63PEDPxE1w MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR6Nkm1OEc,Ojl2OE[5OVQ9N2F-
HCT116 M3HudWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlX3OFghcHK| NUDMe4lPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjJ3IN88UU4> M2roeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEi2PVU1Lz5{OUS4Olk2PDxxYU6=
A549 NGnXOVFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYexfmxDPDhiaILz NIT5dWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG5MlUzKM7:TT6= NGX2RpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS4Olk2PCd-Mkm0PFY6PTR:L3G+
HepG2 M1vpbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWO0PEBpenN? NUHkVJFYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvPiEQvF2u M3LKcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEi2PVU1Lz5{OUS4Olk2PDxxYU6=
HeLa NYLYNJRFS3m2b4TvfIlkcXS7IHHzd4F6 NFvYcIdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI5KM7:TT6= M4i3UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEi5N|YyLz5{OUS4PVM3OTxxYU6=
A549 MonYR5l1d3SxeHnjbZR6KGG|c3H5 MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2Mlgh|ryPLh?= NHrrb3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS4PVM3OSd-Mkm0PFk{PjF:L3G+
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SMMC7721 MlH2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYqyOEBpenN? NIHvc5RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPNUWM4PzJzIHPlcIx{KGGodHXyJFI1KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkS3JO69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR7OUS5NEc,Ojl2OUm0PVA9N2F-
QGY7703 MmrURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NV\obGRZOjRiaILz NEDaNnZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGHHXVc4ODNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTRwMjFOwG0v NWnQd|lJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PVk1QTBpPkK5OFk6PDlyPD;hQi=>
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Bel7402 M3jITWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWT5ZZVjPzJiaILz MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG4MlQ6KM7:TT6= NFi4dGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWyOFczQCd-Mkm1NlQ4Ojh:L3G+
PC3 NHH0cmFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2Twb|czKGi{cx?= NEX4N3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuPFYh|ryPLh?= NXPLeWZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NlQ4OjhpPkK5OVI1PzJ6PD;hQi=>
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HCT15 MYLDfZRwfG:6aXPpeJkh[XO|YYm= MnXxO|IhcHK| M4\tU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDF3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS56NzFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODNzOES0NEc,OzB|MUi0OFA9N2F-
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Assay
Methods Test Index PMID
Western blot p53 / PUMA / c-PARP 25965911
Immunofluorescence caveolin-3 ; phospho-histone H3 ; p65 / p-p65(Ser536) / p53 / p-p53(Ser15) ; Sox2 / Oct4 / Nanog / ABCG2 ; β-catenin ; non-phospho β-catenin 23646193 24587255 27009861 30111797 28588704
Growth inhibition assay Cell viability ; Cell proliferation 25965911 30250641
In vivo Adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. [1] 100mg/kg Adrucil significantly suppresses tumor growth of murine colon carcinomas Colon 38 with tumor-doubling time (TD), growth-delay factor (GDF), and T/C of 26.5 days, 4.4, and 14%. [5]

Protocol (from reference)

Cell Research:[4]
  • Cell lines: Human colon carcinoma cell line HT-29
  • Concentrations: ~25 μM
  • Incubation Time: 7 days
  • Method: Growth inhibition is measured after treatment of cells with Adrucil for 7 days in 96-well plates (4000 HT-29 cells/well in RPMI 1640 medium with 10% dialyzed fetal bovine serum); increasing concentrations of Adrucil are added after allowing for cell attachment overnight. At the end of incubation, cells are rinsed three times with phosphate-buffered saline (pH 7.4), fixed with 10% trichloroacetic acid for 60 min at 4 ℃, washed five times with deionized water, and stained with 0.4% sulforhoda-mine B solution for 15 min at room temperature. Unstained sulforhodamine B is removed by rinsing with 1% glacial acetic acid. Afterwards, stained cell proteins are dried and dissolved with 10 mM Tris-HCl. The optical density value is measured using a detector at 540 nm wavelength.
  • (Only for Reference)
Animal Research:[5]
  • Animal Models: Murine colon carcinomas Colon 38
  • Dosages: 100 mg/kg
  • Administration: i.p. weekly
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 26 mg/mL
(199.87 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
saline (warming)
For best results, use promptly after mixing.

10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 130.08
Formula

C4H3FN2O2

CAS No. 51-21-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(C(=O)NC(=O)N1)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04274790 Not yet recruiting Procedure: Scheduled and planned surgery Cancer of Colon|Metastasis to Liver Centre Leon Berard June 1 2021 --
NCT04825288 Recruiting Biological: XB2001 or Placebo Pancreatic Cancer XBiotech Inc. May 27 2021 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I was wondering if the product #s1209 (5-fluorouracil) is suitable to inject into mice ?

Answer:
S1209 is suitable to inject (I.P.) into mice as indicating in this paper: http://www.ncbi.nlm.nih.gov/pubmed/8995503.

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