Fluorouracil (5-Fluorouracil, 5-FU)

For research use only.

Catalog No.S1209 Synonyms: NSC 19893

107 publications

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

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Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 107 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 M1rOVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXIU4k4OsLiaNMg MV3JR|UxRiB{NTFOwIcwdUx? NWLrWWJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HL-60 NGLaRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnkWmR[PzMEoHlCpC=> MXrJR|UxRThwNkCxJO69\y:vTB?= M4LM[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
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SW480 MnPJRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYLhT4pwPzJiaILz M17m[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e0PFAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTC4MlEh|ryPLh?= NH3oNVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
MDA-MB-435S M1GxZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3jQ[|czKGi{cx?= MkXMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDN3UzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NEA:KDF2LkWg{txONg>? NGPjOmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
HCCLM7 M{XTW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1LmT|czKGi{cx?= MkjMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ1PMUVch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTCxPE43KM7:TT6= MlS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3MkS2OVUoRjF5NUK0OlU2RC:jPh?=
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embryonic cell NY[1eldOTnWwY4Tpc44h[XO|YYm= M2PoWWlv\HWldHnvckBw\iClbHXheoFo\SCjcoLld5QhcW5iZX3idplwdmmlIHPlcIx{KG:oIIP0ZYdmKDhiWHXuc5B2eyCuYXX2bZMh[myjc4T1cIFmNCCLQ{WwJF0hOjZwODFOwG0v NE\0R2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK3NVU2QCd-MUiyO|E2PTh:L3G+
HepG2 M3HF[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NEDhRpNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiSVO1NEA:KDF6Lkeg{txONg>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyMkOzOkc,OTh|MEKzN|Y9N2F-
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UACC257 Mn\US5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4fN[|Q5KGi{cx?= MljVS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gWWFESzJ3NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEOuOVQ5OTNizszNMi=> NGnJWHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
SNB19 NYDZOZc{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\4V|A1QCCqcoO= NY\YOFJxT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW06EMUmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCzMlgxOTh7IN88UU4> NIPlZXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
OVCAR4 NUD6bXRrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NITQTW01QCCqcoO= NYTEb|F6T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWK0JINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gOE41PjZ6NDFOwG0v NEjJ[4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
MDA-MB-231 M{fOeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX65TpQzPDhiaILz MVLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gOk43ODZ7MzFOwG0v MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
NCI-H522 Mk\KS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkP6OFghcHK| MXzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDV{MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEeuNlQ1OzZizszNMi=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
T47D MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDDOFghcHK| NISxWVJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOD6xNlg{OSEQvF2u M1TnbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
CCRF-CEM NH7mbJhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIX3fYI1QCCqcoO= MljUS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR2NTTi2FRV2gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTC5Mlc4OjN5IN88UU4> M1uxXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
Hs 578T MoPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIToOYU1QCCqcoO= Mnj3S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTJMhPTd6VDDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEmuO|czOzdizszNMi=> M{\RR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
BT549 NXXEW5J[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkHzOFghcHK| MnLMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD63NVUzKM7:TT6= NWSzc5d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
OVCAR5 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYXveVVLPDhiaILz MmTaS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ3IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMUCuPVY1QCEQvF2u Mn7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
SKOV3 M2T4TWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVi0PEBpenN? MVLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTT29XOyClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJzLki3O|Yh|ryPLh?= MoTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
HCT116 NUS1bm9MSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYi3NkBpenN? Mlz5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOg[ZhxemW|c3nu[{BxPTNiYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:gZZN{[XluIFnDOVAhRSBzMjFOwG0v NHTLOIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
A2780 NUDYNFBJSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFTvTGo4OiCqcoO= M4L5OmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOg[ZhxemW|c3nu[{BxPTNiYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:gZZN{[XluIFnDOVAhRSBzNDFOwG0v Mlr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6N{O3OFAoRjJyOEezO|QxRC:jPh?=
U2OS NHHBb2xCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWK3NkBpenN? NYK3XYFpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNm9UKGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIF{e2G7LDDJR|UxKD1iMU[g{txONg>? NVXjNoRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
p53 deficient PC3 NWCxPFZKSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{jrc|czKGi{cx?= MoXwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyNUOg[IVncWOrZX70JHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdyCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NFj5[oI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
SF539 NFL3eHZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Ml:0O|IhcHK| NF7FXZFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPGOVM6KGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIF{e2G7LDDJR|UxKD1iNEOg{txONg>? NGTybFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
HCT15 MlHVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4LhNFczKGi{cx?= NVHHV2dvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{Bie3OjeTygTWM2OCB;IES4JO69VS5? NH;5bnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
T3M4 NHu0bJpEgXSxdH;4bYNqfHliYYPzZZk> MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUN201KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nMEBKSzVyIE2gNE4{OyEQvF2u NUHYWJNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
Colo-357 M4TGUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDc4xwNTN3NzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwMEWg{txONg>? M2G2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUOwNVI{Lz5{MEmzNFEzOzxxYU6=
Patu-T NETLVlFEgXSxdH;4bYNqfHliYYPzZZk> NUjwdmlPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWGG2dT3UJINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxKD1iMj6wPEDPxE1w NEf3V4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-S M2DNdWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1nrSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvUzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwOUOg{txONg>? M37XUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUOwNVI{Lz5{MEmzNFEzOzxxYU6=
Aspc-1 NX;YcYxRS3m2b4TvfIlkcXS7IHHzd4F6 NFXnUY9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCe3ClLUGgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB{Lkm3JO69VS5? NIXYco49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
PANC1 NHTa[ohEgXSxdH;4bYNqfHliYYPzZZk> MmjMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUCgQUA{Njl2IN88UU4> M4rFZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUOwNVI{Lz5{MEmzNFEzOzxxYU6=
Patu-02 NULjN|JxS3m2b4TvfIlkcXS7IHHzd4F6 M2W5[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvMEKgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB|Lkm1JO69VS5? MlziQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
DAN-G MYHDfZRwfG:6aXPpeJkh[XO|YYm= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDERW4uTyClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3MDC9JFQvOzhizszNMi=> NWrkfnU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
Patu-T NWT6cmF1S3m2b4TvfIlkcXS7IHHzd4F6 NVjIVGlpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPS2IVT3y[ZNqe3SjboSgVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOzNwMjFOwG0v NH;5eJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Hep2 MmLCRY51cWOjbnPldkBie3OjeR?= Mn24OFghcHK| NXvk[oZKSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
A549 M2fBR2FvfGmlYX7j[ZIh[XO|YYm= MXy0PEBpenN? NXnDNXN7SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFIvPCEQvF2u NFjGNlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC3OFQ1PCd-MkGwO|Q1PDR:L3G+
HCT15 M{jjXGFvfGmlYX7j[ZIh[XO|YYm= M2r4eFQ5KGi{cx?= MoPiRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlYh|ryPLh?= MkPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
502713 NX;iV3c2SW62aXPhcoNmeiCjc4PhfS=> MVK0PEBpenN? MoTBRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIEWwNlcyOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE43KM7:TT6= NV;jXnlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
DU145 MUnBcpRq[2GwY3XyJIF{e2G7 MoDaOFghcHK| M4m3fWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE45KM7:TT6= NHrFWlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC3OFQ1PCd-MkGwO|Q1PDR:L3G+
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colon cancer cell NGXhZ49EgXSxdH;4bYNqfHliYYPzZZk> NWnYOXB5PDhiaILz M1T3U2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgZ492dHSncjDjc5VvfGmwZzygS2k2OCB;IEiuOEDPxE1w NXrje|lxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOVYzPzdpPkKyNFU3Ojd5PD;hQi=>
leukemia cell NVuyRndsS3m2b4TvfIlkcXS7IHHzd4F6 NUTheIdLPDhiaILz Mn3wR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTpcoctKEeLNUCgQUAyPS5zIN88UU4> NIXlO2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC1OlI4Pyd-MkKwOVYzPzd:L3G+
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MCF7 NEHDZ3FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3n5bFczKGi{cx?= NInEbJlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuOlch|ryPLh?= MnnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzO|goRjJ{MEe5N|c5RC:jPh?=
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MGC803 M3X2OWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NV25dnVEPzJiaILz MofmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPR1O4NFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlYh|ryPLh?= NV2zXWZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwO|k{PzhpPkKyNFc6Ozd6PD;hQi=>
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colon cancer cell M4qxT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUi0PEBpenN? MXrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUA5NjRizszNMi=> M3vEdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUG5NVUyLz5{MkGxPVE2OTxxYU6=
leukemia cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnZV5A4PDhiaILz NU\IUIVrT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUAyPS5zIN88UU4> NUfvTWZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVkyPTFpPkKyNVE6OTVzPD;hQi=>
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H460 NULzO|BiS3m2b4TvfIlkcXS7IHHzd4F6 MnnMO|IhcHK| NIHhXHVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{KM7:TT6= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|MEGzNkc,OjJzM{CxN|I9N2F-
HCT116 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MkDMO|IhcHK| M2PUTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPCEQvF2u NXHxcIkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|AyOzJpPkKyNVMxOTN{PD;hQi=>
MCF7 M2DGUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjKWWhTPzJiaILz MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOEDPxE1w MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|MEGzNkc,OjJzM{CxN|I9N2F-
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QGY7701 M2r0SGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHn6VI8zPCCqcoO= NXr5bHA4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWUe\N{ewNUBk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUSuN{DPxE1w NYK5TIViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxPFI6OjZpPkKyNVgzQTJ4PD;hQi=>
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NCI-H460 NX;OeGNOS3m2b4TvfIlkcXS7IHHzd4F6 MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyxiSVO1NEA:KDhizszNMi=> NHLYd2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q2OSd-MkKyPFM1PTF:L3G+
SMMC7721 Ml;lR5l1d3SxeHnjbZR6KGG|c3H5 MnPER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNuIFnDOVAhRSBzNTFOwG0v NXz3UolSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1PTFpPkKyNlg{PDVzPD;hQi=>
MCF7 M3rzWmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHO1ZoVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{NCCLQ{WwJF0hOzFizszNMi=> M1TpWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFUyLz5{MkK4N|Q2OTxxYU6=
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Hep2 NYHxOlJQS3m2b4TvfIlkcXS7IHHzd4F6 M33IU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOVgh|ryPLh?= NH:yUXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
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A549 M1rxbGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIGyV5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOxMlUzKM7:TT6= NXzJdI5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
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HT1080 MlHjR5l1d3SxeHnjbZR6KGG|c3H5 M4T2d|Q5KGi{cx?= MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjJizszNMi=> M3f3e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[3OVQ6Lz5{M{C2O|U1QTxxYU6=
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2008 NFrUXWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjCyNFA5KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JIF{e2G7LDDJR|UxKD1iND6yJO69VS5? NHHrSWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3OVQyPCd-MkOwO|U1OTR:L3G+
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HepG2 MX\DfZRwfG:6aXPpeJkh[XO|YYm= M1XZZlQ5KGi{cx?= NYrCdphtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRyLkO0JO69VS5? NHOyWok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
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MCF7 MkHkR5l1d3SxeHnjbZR6KGG|c3H5 MVm3NkBpenN? Mmf3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4{OyEQvF2u NHTaUWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFE6Oyd-MkO2OFQyQTN:L3G+
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HCT116 M1f1dmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkftO|IhcHK| MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT61N{DPxE1w NIrHbXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2OVExPid-MkO2OlUyODZ:L3G+
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A549 NGTlW3JEgXSxdH;4bYNqfHliYYPzZZk> NWnPOWc5PDhiaILz NXP4XnE1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl{MEK0Okc,OjN7MkCyOFY9N2F-
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leukemia MWHDfZRwfG:6aXPpeJkh[XO|YYm= NYLiPHF6PDhiaILz NGm4TVFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMT61NUDPxE1w M1mzR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm0N|I5Lz5{M{m5OFMzQDxxYU6=
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HT1080 Mn20S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2PlUVQ5KGi{cx?= MWjHdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKEiWMUC4NEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuOlIh|ryPLh?= NXj3PJRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
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Bel7404 M{LwZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGL4cpQ1QCCqcoO= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB2IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPi56IN88UU4> MoP6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NkW5NFUoRjJ2NU[1PVA2RC:jPh?=
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HeLa M2DPOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkOxOFghcHK| Mn7XR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvOzNizszNMi=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3M{CyPUc,OjR7NUOwNlk9N2F-
A549 M{\Hb2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3\D[FQ5KGi{cx?= M2DOTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM1NjN2IN88UU4> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3M{CyPUc,OjR7NUOwNlk9N2F-
HepG2 M1HiOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYi0PEBpenN? Mnv3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM5NjN2IN88UU4> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3M{CyPUc,OjR7NUOwNlk9N2F-
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MGC803 M4j4O2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXrFRXdkPDhiaILz NVvsZnN4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Nj65N{DPxE1w NW\2[FlERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVMxOjlpPkK0PVU{ODJ7PD;hQi=>
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MGC803 NXzCWYN1SW62aXPhcoNmeiCjc4PhfS=> NF7mRlI4OiCqcoO= MYXBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlQ2KM7:TT6= NHe2XGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwNVQ5Oid-MkWwNFE1QDJ:L3G+
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MDA-MB-231 NUPNcFhrS3m2b4TvfIlkcXS7IHHzd4F6 MXe0PEBpenN? M1fwXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlYh|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTBzNkKzOEc,OjVyMU[yN|Q9N2F-
A549 MkXuR5l1d3SxeHnjbZR6KGG|c3H5 M3L0SlQ5KGi{cx?= M2jrdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM2NjRzIN88UU4> M2fSbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEG2NlM1Lz5{NUCxOlI{PDxxYU6=
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HepG2 NFTJWoREgXSxdH;4bYNqfHliYYPzZZk> MoLyOFghcHK| NVXM[pBTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR4LkizJO69VS5? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTBzNkKzOEc,OjVyMU[yN|Q9N2F-
HCT116 M2fTS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVe3VVlrPzJiaILz NEXFXmhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDBwNTFOwG0v NEjZO2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2OlI5Oid-MkWwOlYzQDJ:L3G+
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SGC7901 Mni4R5l1d3SxeHnjbZR6KGG|c3H5 NH76dnA1QCCqcoO= M1uxfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwNU[g{txONg>? NVLPdFRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OVQ6OjJpPkK1OVU1QTJ{PD;hQi=>
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LoVo NYPhW3JlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXy3NkBpenN? M4TiXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFQvPjlizszNMi=> NVPNZpNwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
doxorubicin-resistant LoVo/DX NI\hT21CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIjVN4s4OiCqcoO= M2fqRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JGxwXm9xRGigZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBu\XSqb3SsJGlEPTBiPTC2JO69VS5? MmfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
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vincristine-resistant HL60/Vinc MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWTabGlkPzJiaILz MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKH[rbnPybZN1cW6nLYLld4l{fGGwdDDIUFYxN1[rbnOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKxMlE2KM7:TT6= MmnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
HL60 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1HqPFczKGi{cx?= NF3kdYhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIzNjV2IN88UU4> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ2NE[3OEc,OjV4NES2O|Q9N2F-
HT-29 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlO0O|IhcHK| NWjqfXFySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIH3leIhw\CxiSVO1NEA:KDJ3LkC4JO69VS5? NUXqZmNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
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B16F10 MULBcpRq[2GwY3XyJIF{e2G7 NUXTNVdMPzJiaILz NHrKWnRCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3TjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT60N{DPxE1w M{XjW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW1O|E5Lz5{NU[1OVcyQDxxYU6=
MGC803 NF\hVnBCdnSrY3HuZ4VzKGG|c3H5 MmL2O|IhcHK| NGnPZo5CdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD60N{DPxE1w MmnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUW3NVgoRjJ3NkW1O|E5RC:jPh?=
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HCT8 NH;WSZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NICxcXo4OiCqcoO= MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEigZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOUGg{txONg>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ5NUG0OEc,OjV4N{WxOFQ9N2F-
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Bel7402 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NUDoSGhIPzJiaILz MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC5yNzFOwG0v MnXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{Mke3O|coRjJ4MkK3O|c4RC:jPh?=
A549 M{DzN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NH;iV|U4OiCqcoO= NV;rOWx5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwMUWg{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{N{e3O{c,OjZ{Mke3O|c9N2F-
HepG2 NWDCeZpqS3m2b4TvfIlkcXS7IHHzd4F6 M3S1XlczKGi{cx?= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvPDJizszNMi=> M{m4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK3O|c4Lz5{NkKyO|c4PzxxYU6=
A549 NEfnbFlCdnSrY3HuZ4VzKGG|c3H5 MmTrOFghcHK| MXzBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj6xN{DPxE1w MlHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GwPFAoRjJ4MkOxNFgxRC:jPh?=
MCF7 M1G4R2FvfGmlYX7j[ZIh[XO|YYm= M2m3[lQ5KGi{cx?= MlPQRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|Yh|ryPLh?= MoeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GwPFAoRjJ4MkOxNFgxRC:jPh?=
HeLa MmPHRY51cWOjbnPldkBie3OjeR?= NHPjVpc1QCCqcoO= M2[yO2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlYh|ryPLh?= NUjUW5hVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yN|ExQDBpPkK2NlMyODhyPD;hQi=>
HaCaT NFzhd|hEgXSxdH;4bYNqfHliYYPzZZk> NHm0O3c1QCCqcoO= M3rBcmN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjhR4FVKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU4zPiEQvF2u NF;PUXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzNVA5OCd-Mk[yN|ExQDB:L3G+
Hep3B MoHOR5l1d3SxeHnjbZR6KGG|c3H5 MVmyJIRigXN? MoXMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJINmdGxiZHXheIghcW6ldXLheIVlKG[xcjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU42KM7:TT6= NYnMfZZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVk5ODJpPkK2NlU6QDB{PD;hQi=>
Bcap37 MmfpR5l1d3SxeHnjbZR6KGG|c3H5 MYmyJIRigXN? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJINmdGxiZHXheIghcW6ldXLheIVlKG[xcjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU42QCEQvF2u MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OUiwNkc,OjZ{NUm4NFI9N2F-
MCF7 MnvTR5l1d3SxeHnjbZR6KGG|c3H5 MkXhNkBl[Xm| NI[3WIJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEyNjVizszNMi=> NILxSHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PVgxOid-Mk[yOVk5ODJ:L3G+
HepG2 Mli3R5l1d3SxeHnjbZR6KGG|c3H5 MXWyJIRigXN? NVfuN3FZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGOnbHyg[IVifGhiaX7jeYJifGWmIH\vdkAzKGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwM{Sg{txONg>? NEDSUIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PVgxOid-Mk[yOVk5ODJ:L3G+
A549 MVXDfZRwfG:6aXPpeJkh[XO|YYm= Mk\qNkBl[Xm| MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIlv[3WkYYTl[EBnd3JiMjDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IES0MlA2KM7:TT6= Mn\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NUm4NFIoRjJ4MkW5PFAzRC:jPh?=
SW620 NGXMUlhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXW3NkBpenN? MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNkKwJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwN{mg{txONg>? M1;PNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkmxNFM5Lz5{NkK5NVA{QDxxYU6=
MIAPaCa2 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYe3NkBpenN? M{\XbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVnBVIFE[TJiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVEvPjdizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ7MUCzPEc,OjZ{OUGwN|g9N2F-
MCF7 M{nrNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkLuOFghcHK| M{\3[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6wNVIh|ryPLh?= NHrFbG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOwNVU2QCd-Mk[zNFE2PTh:L3G+
DU145 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4LHflQ5KGi{cx?= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4LkC3NkDPxE1w M{GyOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{CxOVU5Lz5{NkOwNVU2QDxxYU6=
A549 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkPUOFghcHK| MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwMkS0JO69VS5? NGTS[pM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOwNVU2QCd-Mk[zNFE2PTh:L3G+
HeLa M2XjVGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{LLOlQ5KGi{cx?= MkfDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkOxO{DPxE1w NUXvTo1MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNFE2PThpPkK2N|AyPTV6PD;hQi=>
MCF7 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M2jSS|Q5KGi{cx?= NXP3NVU3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwM{mg{txONg>? Mn;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NkO4OlkoRjJ4M{[zPFY6RC:jPh?=
A549 NV\NRY15S3m2b4TvfIlkcXS7IHHzd4F6 MX:0PEBpenN? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNk4zQCEQvF2u M4DaPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{[zPFY6Lz5{NkO2N|g3QTxxYU6=
PC3 M2\vSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWS0PEBpenN? M1i4TWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlIvPjNizszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN4M{i2PUc,OjZ|NkO4Olk9N2F-
HepG2 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MXq0PEBpenN? NXnDeItHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR4LkizJO69VS5? MoHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NkO4OlkoRjJ4M{[zPFY6RC:jPh?=
HT-29 NVrse4Z7S3m2b4TvfIlkcXS7IHHzd4F6 NHPjTFA1QCCqcoO= NH3vNIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliV2PUMVEh[XO|YYmsJGlEPTBiPTCxOU45OyEQvF2u NEHZ[GM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSxN|czPSd-Mk[0NVM4OjV:L3G+
PA1 MUnBcpRq[2GwY3XyJIF{e2G7 MkTjOFghcHK| MlzNRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz61PUDPxE1w MlHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MUO3NlYoRjJ4NEGzO|I3RC:jPh?=
BT549 M1WwWGFvfGmlYX7j[ZIh[XO|YYm= NFT4UII1QCCqcoO= MUTBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQmS1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG5MlgzKM7:TT6= NUXlWoY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NVM4OjZpPkK2OFE{PzJ4PD;hQi=>
DU145 MVfBcpRq[2GwY3XyJIF{e2G7 Mo\oOFghcHK| NEj4VFFCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM6NjF5IN88UU4> NXv3NWVtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NVM4OjZpPkK2OFE{PzJ4PD;hQi=>
MDA-MB-231 NV[zUZNMSW62aXPhcoNmeiCjc4PhfS=> Mly5OFghcHK| M2P5XGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2NT60N{DPxE1w MkXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MUO3NlYoRjJ4NEGzO|I3RC:jPh?=
SH-SY5Y M3vRUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIizV|Q4OiCqcoO= MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOKLWPZOXkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWE1j[XOnZDDNc5Nu[W6wIHHzd4F6KHKnbHH0bZZmKHSxIHPvcpRzd2xuIFfJOVAhRSBzLkWg{txONg>? MoXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3M{m2NlYoRjJ4NUO5OlI3RC:jPh?=
Caco2 MkLqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4myT|czKGi{cx?= NWLkTmhtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDZYNwOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVNWKjc3XkJG1we22jbn6gZZN{[XlicnXsZZRqfmVidH:gZ49vfHKxbDygS2k2OCB;IEKuNkDPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV|OU[yOkc,OjZ3M{m2NlY9N2F-
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HT-29 NIL3e5VCdnSrY3HuZ4VzKGG|c3H5 MoHVOFghcHK| M4TqcWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPSEQvF2u NHnkS2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlI{Oyd-Mk[5NlIzOzN:L3G+
HCT116 MnjURY51cWOjbnPldkBie3OjeR?= MWe3NkBpenN? NHi3e2lCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5Lkig{txONg>? NGiwUYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlI{Oyd-Mk[5NlIzOzN:L3G+
RKO NV3DdYlTSW62aXPhcoNmeiCjc4PhfS=> NFH4NGY1QCCqcoO= MnrpRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLLU{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NU4yKM7:TT6= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKzN{c,OjZ7MkKyN|M9N2F-
KB MlqzR5l1d3SxeHnjbZR6KGG|c3H5 MWO3NkBpenN? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iND64OEDPxE1w NWDPN|RnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
HeLa MnPmR5l1d3SxeHnjbZR6KGG|c3H5 NX\oT2dYPzJiaILz NVPLOXlDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi5{MzFOwG0v NWnRbY5MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
MCF7 MlTQR5l1d3SxeHnjbZR6KGG|c3H5 MYm3NkBpenN? NHvWXYhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5Y3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFYvPTNizszNMi=> NGTJW|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
HepG2 NGfxWmJEgXSxdH;4bYNqfHliYYPzZZk> NHLGRlc4OiCqcoO= NHHUfZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi54IN88UU4> MnPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
HDF M3XqVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NY\GOnUxPzJiaILz M134dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiGRjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPy5yMjFOwG0v NWTv[ZZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
143B MlP1R5l1d3SxeHnjbZR6KGG|c3H5 MYe3NkBpenN? MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCxOFNDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxN{4xOSEQvF2u NELMeHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
thymidine kinase deficient 143B NXnDemhQS3m2b4TvfIlkcXS7IHHzd4F6 M3vxcFczKGi{cx?= NVPtSllES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhOTR|QjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOTZwM{Gg{txONg>? NXizb4xqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
U87MG NEjnWYdEgXSxdH;4bYNqfHliYYPzZZk> NIP2TWk4OiCqcoO= MniwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4VUdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCcMjDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOThwMkWg{txONg>? NGfqNG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C4NVc1Oid-MkewPFE4PDJ:L3G+
PC3 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWS0PEBpenN? MoSwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwN{[g{txONg>? MljxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOUK0NVMoRjJ5MEmyOFE{RC:jPh?=
HT-29 MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVi0PEBpenN? NXHQ[3p7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk45KM7:TT6= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
U87MG MX3BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHTGVmo1QCCqcoO= MoDRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz62OUDPxE1w MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
A549 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4PPblQ5KGi{cx?= MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwOUig{txONg>? MkPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOUK0NVMoRjJ5MEmyOFE{RC:jPh?=
HaCaT MnjGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4TZVVQ5KGi{cx?= NY\jNnUySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIZWNiXCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvOTVizszNMi=> M1W4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
MGC803 Mn7mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{\qXlczKGi{cx?= NW\VXmFvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4zPSEQvF2u M4rnb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
EC109 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4iyRVczKGi{cx?= MlT1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ{GwPUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkG3JO69VS5? Mlq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
SH-SY5Y NHHxNnJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX:3NkBpenN? MojaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNlYh|ryPLh?= M2HuWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC1NFI5Lz5{N{GwOVAzQDxxYU6=
U87 Mn;qRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2e0fFczKGi{cx?= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6NzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjZzIN88UU4> NHHsO409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
MCF7 MnjrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWm3NkBpenN? NUPu[pdjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuOlEh|ryPLh?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyNUCyPEc,OjdzMEWwNlg9N2F-
MDA-MB-231 NXm0em1{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoDGOFghcHK| MnHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC54IN88UU4> MkDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixPFAoRjJ5MUK4NVgxRC:jPh?=
MCF7 NEHwcIVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mo\yOFghcHK| NXnOS44zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNE41OSEQvF2u NUHFVYhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyQDBpPkK3NVI5OThyPD;hQi=>
A549 NF70PXBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M17wdFQ5KGi{cx?= NFHrV2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1MlQyKM7:TT6= MnL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixPFAoRjJ5MUK4NVgxRC:jPh?=
HepG2 M4DDOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWDLOW1sPDhiaILz MmDkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNE[uPFMh|ryPLh?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG4NEc,OjdzMkixPFA9N2F-
MCF7 MXzDfZRwfG:6aXPpeJkh[XO|YYm= MXO0PEBpenN? MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{42KM7:TT6= MnfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
Bcap37 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NWLvcXozPDhiaILz MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjR5IN88UU4> MoC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
Hep3B MlrMR5l1d3SxeHnjbZR6KGG|c3H5 MXW0PEBpenN? MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVcvPTNizszNMi=> NY\Dc5VWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexN|M2QTNpPkK3NVM{PTl|PD;hQi=>
A549 MnOwR5l1d3SxeHnjbZR6KGG|c3H5 M3fQN|Q5KGi{cx?= MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU42QCEQvF2u MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
U251 NXrLVW1LS3m2b4TvfIlkcXS7IHHzd4F6 M2PNb|Q5KGi{cx?= NEPOd4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC54OTFOwG0v NG\PcnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzN|U6Oyd-MkexN|M2QTN:L3G+
HepG2 NILPdGtEgXSxdH;4bYNqfHliYYPzZZk> M{D6cFQ5KGi{cx?= NGHEU4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjVwMUeg{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
LNCAP NES1VodEgXSxdH;4bYNqfHliYYPzZZk> M4rsNlI1KGi{cx?= NWPsOZFDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMkSgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> M{TsSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUW2O|cxLz5{N{G1Olc4ODxxYU6=
PC3 NXTBco5FS3m2b4TvfIlkcXS7IHHzd4F6 NX7BdI04OjRiaILz MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgNlQhcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVAhRSByLkCzJO69VS5? Mli2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNU[3O|AoRjJ5MUW2O|cxRC:jPh?=
Bcap37 MlvzR5l1d3SxeHnjbZR6KGG|c3H5 NWqxZ3ZbPDhiaILz M4q5XWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6xPEDPxE1w NWXuO4lCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFk3PzZpPkK3NVg6Pjd4PD;hQi=>
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HepG2 M{jkZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVm0PEBpenN? NHnYRmxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Ok45OyEQvF2u NFPYUFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{K4O|M3QCd-MkeyPFc{Pjh:L3G+
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A498 M{KyOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGL0fHM1QCCqcoO= NXXXTJZSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDy[YR2[3Srb36gZZN{[XluIFnDOVAhRSB6LkizJO69VS5? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ7NUWwOkc,Ojd{OUW1NFY9N2F-
A549 MoPGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3fGNlczKGi{cx?= M2PYUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JHdUXC16IHHzd4F6NCCLQ{WwJF0hOi56IN88UU4> NIC3N|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{OxNVg6PSd-MkezNVE5QTV:L3G+
MDA-MB-231 M1LJVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn31O|IhcHK| NWHYZWtPSW62aYDyc4xq\mW{YYTpc44h[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgW3NVNThiYYPzZZktKEmFNUCgQUA2NjJizszNMi=> NGf5RZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{OxNVg6PSd-MkezNVE5QTV:L3G+
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A549 NUPT[HF{S3m2b4TvfIlkcXS7IHHzd4F6 Mne3O|IhcHK| NETYZldEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA3NjhizszNMi=> NIruNnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
SGC7901 NIPtNGNEgXSxdH;4bYNqfHliYYPzZZk> NGH5VZI4OiCqcoO= M17teWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLkmg{txONg>? M1PSWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUO3PVI1Lz5{N{WzO|kzPDxxYU6=
MDA-MB-435S Mkf1R5l1d3SxeHnjbZR6KGG|c3H5 M2LuWVczKGi{cx?= NWHaT3dQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PVNiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjJizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV|N{myOEc,Ojd3M{e5NlQ9N2F-
PC3 MlzYR5l1d3SxeHnjbZR6KGG|c3H5 NHi1bm44OiCqcoO= MkLhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Nk42KM7:TT6= NFfqWm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WzO|kzPCd-Mke1N|c6OjR:L3G+
colon cancer cell NIfUZ49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3;WWFQ5KGi{cx?= Mn;WS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTC4MlQh|ryPLh?= NXK4WGxuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OVQ1PDRpPkK3OVU1PDR2PD;hQi=>
leukemia cell NGXUU5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYLnfIdiPDhiaILz M4rP[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSBzNT6xJO69VS5? NVT5bmRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OVQ1PDRpPkK3OVU1PDR2PD;hQi=>
prostate cancer cell NHi3TlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3W1[lQ5KGi{cx?= MXXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFIzNjdizszNMi=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV3NES0OEc,Ojd3NUS0OFQ9N2F-
renal cancer cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUfDdIJuPDhiaILz NInBRXFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFQ2NjZizszNMi=> MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUS0OFQoRjJ5NUW0OFQ1RC:jPh?=
DU145 NV3MdlBDS3m2b4TvfIlkcXS7IHHzd4F6 M3HBb|Q5KGi{cx?= MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4LkGg{txONg>? M2\WUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E5Lz5{N{W2NVcyQDxxYU6=
HeLa NIT6e|VEgXSxdH;4bYNqfHliYYPzZZk> NEPNcI41QCCqcoO= MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjhwMjFOwG0v MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV4MUexPEc,Ojd3NkG3NVg9N2F-
IOSE-144 NIfBe5ZEgXSxdH;4bYNqfHliYYPzZZk> M2fHS|Q5KGi{cx?= M1Tad2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGlQW0VvMUS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|YvOSEQvF2u MlP6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NkG3NVgoRjJ5NU[xO|E5RC:jPh?=
HepG2 NGPteGhEgXSxdH;4bYNqfHliYYPzZZk> MljyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkOg{txONg>? M3r0OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
DU145 M1:2U2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2fsWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT62JO69VS5? M{fmWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
MDA-MB-231 MnO2R5l1d3SxeHnjbZR6KGG|c3H5 NIPpco5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS56IN88UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV4MUexPUc,Ojd3NkG3NVk9N2F-
HeLa M4GwZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGXEZnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT65JO69VS5? M4HUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
SW780 NUjSTpNqS3m2b4TvfIlkcXS7IHHzd4F6 M13pUFczKGi{cx?= NVr2e|V3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d5OECgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYmsJGlEPTBiPTC2Mlk6KM7:TT6= NUDnZmlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
MGC803 NWjhT21rS3m2b4TvfIlkcXS7IHHzd4F6 NH\VcXM4OiCqcoO= M{SxdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IEGwMlY1KM7:TT6= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV7N{SxNUc,Ojd3OUe0NVE9N2F-
HL-7702 NEP6e2dEgXSxdH;4bYNqfHliYYPzZZk> M{nsNlczKGi{cx?= MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUE04PzB{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUKuPFUh|ryPLh?= M17YNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
MCF7 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MY[3NkBpenN? M3fLN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSBzMz6xPUDPxE1w NEf2fFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W5O|QyOSd-Mke1PVc1OTF:L3G+
GES-1 NEC1XHNEgXSxdH;4bYNqfHliYYPzZZk> MorQO|IhcHK| M1jnUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdGWy1zIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUOuO|Uh|ryPLh?= M3HsOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUm3OFEyLz5{N{W5O|QyOTxxYU6=
TE1 NWrkN2tHS3m2b4TvfIlkcXS7IHHzd4F6 NXLV[nBKPzJiaILz NVTicZJbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEVzIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUeuN|Ih|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV7N{SxNUc,Ojd3OUe0NVE9N2F-
A549 M{LkS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHLONGM1QCCqcoO= NGLpXpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjR5IN88UU4> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZzNESwPEc,Ojd4MUS0NFg9N2F-
MDA-MB-231 M2nk[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M3LMWlQ5KGi{cx?= M1T4Z2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuPVgh|ryPLh?= NEPONpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQxQCd-Mke2NVQ1ODh:L3G+
DU145 NULoNJlKS3m2b4TvfIlkcXS7IHHzd4F6 NF;2OnE1QCCqcoO= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NE42QCEQvF2u MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZzNESwPEc,Ojd4MUS0NFg9N2F-
PC3 M1;BO2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3P6SlQ5KGi{cx?= M1XMWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0OU4{OiEQvF2u NY\0TIlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
MCF7 MlvGR5l1d3SxeHnjbZR6KGG|c3H5 MnnlOFghcHK| NFrBRWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVAhRSB2LkWg{txONg>? NWHM[op2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQDRpPkK3Olg5OTh2PD;hQi=>
HepG2 MX;GeY5kfGmxbjDhd5NigQ>? M1G5SlQ5KGi{cx?= NETiOZJJ\XCjdH;0c5hq[2m2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGdKPTBiPTC3JO69VS5? NWnMT49MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQDRpPkK3Olg5OTh2PD;hQi=>
U87 NIHHd2tHfW6ldHnvckBie3OjeR?= NF7pNGM1QCCqcoO= NGrpZmlP\XW{b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTh5IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVAhRSBzMzFOwG0v NI\5d4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE5PCd-Mke2PFgyQDR:L3G+
HCT116 NF33VGRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfqV484OiCqcoO= NWLpNmxET3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB{LkWg{txONg>? Mn75QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NVEoRjJ5N{C0PFEyRC:jPh?=
HeLa NX\yUYFwS3m2b4TvfIlkcXS7IHHzd4F6 NEfXN2lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT62JO69VS5? Mkm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkCyPVYoRjJ5N{KwNlk3RC:jPh?=
PC3 Mm\XR5l1d3SxeHnjbZR6KGG|c3H5 M1PoRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NF;MZ489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{eyNFI6Pid-Mke3NlAzQTZ:L3G+
HepG2 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NWrneGtERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NlAzQTZpPkK3O|IxOjl4PD;hQi=>
MDA-MB-231 NH22c3VEgXSxdH;4bYNqfHliYYPzZZk> NYTTdppNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwOTFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd{MEK5Okc,Ojd5MkCyPVY9N2F-
L1210 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{LLWFQ5KGi{cx?= M{Hae2FvfGlvcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFyxNlExKGOnbHzzJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOC5|MzFOwG0v MnLnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
HeLa M4j1N2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MonDOEBl[Xm| MonjRY51cS2ycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDt[YF{fXKnZDDh[pRmeiB2IHThfZMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFAvPTRizszNMi=> Mn;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
CEM MnzORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUK3NkBpenN? M3LUR2FvfGlvcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPFUUBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFE5KM7:TT6= NVG4OXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
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MGC803 M2TRWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvOTRizszNMi=> MoHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|QoRjJ5N{[5NFM1RC:jPh?=
A549 MV3DfZRwfG:6aXPpeJkh[XO|YYm= NGPnVHBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{Njl3IN88UU4> NGP4S4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVA{PCd-Mke3OlkxOzR:L3G+
EC109 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M1HkSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVEOTB7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI2Njl7IN88UU4> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OUCzOEc,Ojd5NkmwN|Q9N2F-
MGC803 NVfETVB7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGX2OHg4OiCqcoO= M3\McGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlM2KM7:TT6= NFLRfXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3NVU6QSd-Mke3O|E2QTl:L3G+
MCF7 M3jDZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1LOc|czKGi{cx?= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMkWg{txONg>? NIrpT2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3NVU6QSd-Mke3O|E2QTl:L3G+
EC109 MkT3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mne5O|IhcHK| MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFMUC5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61PUDPxE1w NXHoOG5ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|E2QTlpPkK3O|cyPTl7PD;hQi=>
HUCCA MUTDfZRwfG:6aXPpeJkh[XO|YYm= NVG2XI15OjRiaILz NG\mR2hEgXSxdH;4bYNqfHliYXfhbY5{fCCKVVPDRUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvPCEQvF2u M1foOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEK1O|Y{Lz5{N{iyOVc3OzxxYU6=
QBC939 M{jJ[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlXxNlQhcHK| MoHxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVWJEQTN7IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6xJO69VS5? NEK0NVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyOVc3Oyd-Mke4NlU4PjN:L3G+
SW620 NWj1VlM3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2TrdFczKGi{cx?= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNkKwJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkC4JO69VS5? M3S3dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
CFPAC-1 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2\tWVczKGi{cx?= NI\GPZdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPGVGFENTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTRizszNMi=> NX;RTGFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
WI38 NIPFc2ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXHQVIRpPzJiaILz M4joWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iV1mzPEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD65OEDPxE1w M1;ZflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
A549 MknjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUPZN5pSPzJiaILz M4PWWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj64JO69VS5? M{jO[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEe1O|c6Lz5{N{i3OVc4QTxxYU6=
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HepG2 NITCZ2pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX63NkBpenN? MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6Lkmg{txONg>? Ml3XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6N{W3O|koRjJ5OEe1O|c6RC:jPh?=
Hep3B M4n3UmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwM{[g{txONg>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzM{G3PUc,Ojd7MUOxO|k9N2F-
A549 MV7DfZRwfG:6aXPpeJkh[XO|YYm= MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwNkOg{txONg>? NXfQbHdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NVMyPzlpPkK3PVE{OTd7PD;hQi=>
WISH MkDUR5l1d3SxeHnjbZR6KGG|c3H5 MWOyOEBpenN? NVfMUJpvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX0mVSDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNUDPxE1w NVTkO2ZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OVE1QDdpPkK3PVUyPDh5PD;hQi=>
WI38 NEXrWVBEgXSxdH;4bYNqfHliYYPzZZk> MXGyOEBpenN? MofDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW2k{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMzFOwG0v MmrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NUG0PFcoRjJ5OUWxOFg4RC:jPh?=
A549 NGPnO4FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGTWWYo4OiCqcoO= NG\XfHpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNVYh|ryPLh?= MnjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEe0PFUoRjJ5OUi3OFg2RC:jPh?=
MDA-MB-231 NUSxR5YySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NV;Ve49pPzJiaILz M4LtNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPSEQvF2u NWD1ZnEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFc1QDVpPkK3PVg4PDh3PD;hQi=>
HepG2 MnfHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4n0OFczKGi{cx?= NXHDSnNUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOUDPxE1w MoDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEe0PFUoRjJ5OUi3OFg2RC:jPh?=
MCF7 NYLWWI8xSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2\vb|czKGi{cx?= M13MbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6xNkDPxE1w NV7tWHdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFc1QDVpPkK3PVg4PDh3PD;hQi=>
Hep3B MX\DfZRwfG:6aXPpeJkh[XO|YYm= M1fSV|Q5KGi{cx?= M3;HdGN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldFNDKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC53MzFOwG0v NHKyVoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5N|UyPid-Mke5PVM2OTZ:L3G+
HepG2 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NXr3e4ZJPDhiaILz NXLsbW9pS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN{Lk[g{txONg>? MnGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUO1NVYoRjJ5OUmzOVE3RC:jPh?=
HepG2 NUDOcI1TT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYCyOEBpenN? M1rP[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Oi56NzFOwG0v MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDBzMUKyNEc,OjhyMUGyNlA9N2F-
PA1 M1TqTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M175dFI1KGi{cx?= MkPnS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGEyKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPU42KM7:TT6= NXjEd3hLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNVEzOjBpPkK4NFEyOjJyPD;hQi=>
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MGC803 M1\sdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3fh[|czKGi{cx?= Mn\6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPR1O4NFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNVIh|ryPLh?= NVHOWW0xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
K562 NWXxTmNjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVS3NkBpenN? MkTvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkW0JO69VS5? M1Hq[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
HepG2 MVLDfZRwfG:6aXPpeJkh[XO|YYm= M3LUNVQ5KGi{cx?= NWjRW4VOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlU{KM7:TT6= MkfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzN{SxNFcoRjJ6MUe0NVA4RC:jPh?=
Hep3B M3u1eGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFnXfYk1QCCqcoO= NEDXVIJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEmuO|Ih|ryPLh?= NYjVN25DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixO|QyODdpPkK4NVc1OTB5PD;hQi=>
MCF7 NHrMdnREgXSxdH;4bYNqfHliYYPzZZk> MmPOO|IhcHK| M2\WRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDFwNDFOwG0v MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUmwOFYoRjJ6MkG5NFQ3RC:jPh?=
HCT116 M3jsfWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnvxO|IhcHK| MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDF6LkSg{txONg>? NFjUc3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxPVA1Pid-MkiyNVkxPDZ:L3G+
HuH7 M1fGVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEmwdHE4OiCqcoO= NHfORm1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB{MTFOwG0v Moi2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUmwOFYoRjJ6MkG5NFQ3RC:jPh?=
A549 NV\JTo9VS3m2b4TvfIlkcXS7IHHzd4F6 MnXQNlQhcHK| NYLnXWdSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5{IN88UU4> Ml;RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NUS2PVcoRjJ6MkW0Olk4RC:jPh?=
HeLa M4PXUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUHVc5dPOjRiaILz NXvNc2VLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS52IN88UU4> NEfjPY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK1OFY6Pyd-MkiyOVQ3QTd:L3G+
HepG2 MlPzR5l1d3SxeHnjbZR6KGG|c3H5 MVqyOEBpenN? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= NW\sUW8yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOVQ3QTdpPkK4NlU1Pjl5PD;hQi=>
COLO205 M1TZXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWHORYY5OjRiaILz NH3jRmlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkmg{txONg>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ3NE[5O{c,Ojh{NUS2PVc9N2F-
HepG2 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NVLofGtGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk4yKM7:TT6= NHrselQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK2NlUzPyd-MkiyOlI2Ojd:L3G+
Hep3B M4npWWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1T0NWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOlYh|ryPLh?= MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NkK1NlcoRjJ6Mk[yOVI4RC:jPh?=
Bel7402 MmLZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHf6TZE4OiCqcoO= M3i2W2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA2Njl2IN88UU4> M2ridVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{CxPFE2Lz5{OEOwNVgyPTxxYU6=
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HCT116 NFL3eXNEgXSxdH;4bYNqfHliYYPzZZk> MmnMR5l1d3SxeHnjbZR6KGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEGg{txONg>? M{DwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O0OlU1Lz5{OEOzOFY2PDxxYU6=
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HeLa MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYDaZW12PDhiaILz MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMEKg{txONg>? MmrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NkO0OFQoRjJ6M{[zOFQ1RC:jPh?=
HepG2 NWrLUodCSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mo\vOFghcHK| MmK5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUOuN|Eh|ryPLh?= M3HrdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{[zOFQ1Lz5{OEO2N|Q1PDxxYU6=
BGC823 Mk\5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnXTOFghcHK| MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKJQ{iyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuN|ch|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN4M{S0OEc,Ojh|NkO0OFQ9N2F-
SW1116 NYWyblJQSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHrJeGI1QCCqcoO= NF;CUFVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXNVEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVgvPTJizszNMi=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN4M{S0OEc,Ojh|NkO0OFQ9N2F-
Hep3B M3Ljd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGfIfpBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNU46KM7:TT6= NWjtd5NrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizO|E3PzZpPkK4N|cyPjd4PD;hQi=>
MCF7 MkXmR5l1d3SxeHnjbZR6KGG|c3H5 NEfNUoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOwJO69VS5? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN5MU[3Okc,Ojh|N{G2O|Y9N2F-
HepG2 NXzpS|IzS3m2b4TvfIlkcXS7IHHzd4F6 M3nPVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOyMlYh|ryPLh?= NEfmfWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO3NVY4Pid-MkizO|E3PzZ:L3G+
A549 MkDxR5l1d3SxeHnjbZR6KGG|c3H5 NVm4Vnl4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPE4zKM7:TT6= M{TYc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{exOlc3Lz5{OEO3NVY4PjxxYU6=
MCF7 MoPDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFe4[Jk1QCC2bzC3NkBpenN? MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiaX7jeYJifGWmIH\vdkA1QCC2bzC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{43PyEQvF2u MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN7NUKxPEc,Ojh|OUWyNVg9N2F-
A549 MonjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFvnSIk1QCC2bzC3NkBpenN? MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiaX7jeYJifGWmIH\vdkA1QCC2bzC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPjVizszNMi=> M{HPeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{m1NlE5Lz5{OEO5OVIyQDxxYU6=
SGC7901 MnKwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIr5T5U1QCC2bzC3NkBpenN? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOJQ{e5NFEh[2WubIOgbY5kfWKjdHXkJIZweiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTNwMkWg{txONg>? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN7NUKxPEc,Ojh|OUWyNVg9N2F-
HepG2 Mo\aRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoPOOFghfG9iN{KgbJJ{ NWj3V5k2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BqdmO3YnH0[YQh\m:{IES4JJRwKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNz60OEDPxE1w MkTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OUWyNVgoRjJ6M{m1NlE5RC:jPh?=
PC3 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoK2OFghfG9iN{KgbJJ{ MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KHSxIEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzPE43OSEQvF2u NW\oZmpmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPVUzOThpPkK4N|k2OjF6PD;hQi=>
MCF7 MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYq0PEBpenN? MULHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCxMlY4KM7:TT6= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzOUc,Ojh2MECyN|U9N2F-
A549 MlrXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvKOFghcHK| NGnTTVhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAzNjB7IN88UU4> NGK2UHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{PSd-Mki0NFAzOzV:L3G+
DU145 NHTISpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml7SOFghcHK| MnfhS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFUvQDJizszNMi=> MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MECyN|UoRjJ6NECwNlM2RC:jPh?=
T47D MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWK0PEBpenN? NHfwbm1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS0O2Qh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGyMlEh|ryPLh?= NYPzbnpORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzhpPkK4OFAxOjN6PD;hQi=>
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HGC27 M1nZS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2PEVFczKGi{cx?= NFLEfmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4MlIzKM7:TT6= NGraNo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1OlA{OSd-Mki0OVYxOzF:L3G+
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MCF7 NXrtbINzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX3NVW11PzJiaILz M4[wXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuO|Mh|ryPLh?= NX3uN48xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVgyOzNpPkK4OFU5OTN|PD;hQi=>
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SGC7901 NH\sbldCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1fZTVczKGi{cx?= M4TkfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1fDO|kxOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|QvPCEQvF2u MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ|MkW4N{c,Ojl{M{K1PFM9N2F-
SMMC7721 NWXwOnZFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnX4O|IhcHK| MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOPTVO3O|IyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzO{45KM7:TT6= NVLFVox{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyN|I2QDNpPkK5NlMzPTh|PD;hQi=>
HuH7 M1qxNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1yzc|czKGi{cx?= NHmwc5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFj1TFch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuOlMh|ryPLh?= NFHsXJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOxOlU{Pid-MkmzNVY2OzZ:L3G+
HCT116 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFewTVE4OiCqcoO= M3LJUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNU4zQSEQvF2u MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTNzNkWzOkc,Ojl|MU[1N|Y9N2F-
MGC803 NX3jcIxlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYfNbFdxPzJiaILz M3fWV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU42PCEQvF2u MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTNzNkWzOkc,Ojl|MU[1N|Y9N2F-
MGC803 M{n3WGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGrNXlk4OiCqcoO= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz64OkDPxE1w Mm\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5OFYoRjJ7NEC3PVQ3RC:jPh?=
NCI-H1650 MlK0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MU[3NkBpenN? NXWzNmJFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF4NUCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF2Lk[zJO69VS5? M2nhZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVQ3Lz5{OUSwO|k1PjxxYU6=
PC3 MlrIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MW[3NkBpenN? NX7RWYR{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK3MlYyKM7:TT6= M1\nSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVQ3Lz5{OUSwO|k1PjxxYU6=
HL60 Mn7hRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVu3NkBpenN? NVPCfG1[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlM4KM7:TT6= NXvZNWVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6QDNpPkK5OFA4QTh|PD;hQi=>
Bel7402 NHflV3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MV:3NkBpenN? Mm\DRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPE41QSEQvF2u NGn0NWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k5Oyd-Mkm0NFc6QDN:L3G+
PC3 NIfDbFdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVK3NkBpenN? M3SxNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Mz64OkDPxE1w NXjRNGd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6QDNpPkK5OFA4QTh|PD;hQi=>
EC9706 NUnremRnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXe3NkBpenN? MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFOUewOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6xN{DPxE1w MknoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2N{WxOVYoRjJ7NEe1NVU3RC:jPh?=
EC109 MkK3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2PjNVczKGi{cx?= MoTXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ{GwPUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj6wNkDPxE1w M3zLO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEe1NVU3Lz5{OUS3OVE2PjxxYU6=
PC3 NH;lO2pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFTFZmk4OiCqcoO= MnPLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwMkeg{txONg>? NH[wWGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS3OVE2Pid-Mkm0O|UyPTZ:L3G+
MGC803 NV;SZ|Z7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MU[3NkBpenN? NX7wOZZsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvOjRizszNMi=> M{\QRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEe1NVU3Lz5{OUS3OVE2PjxxYU6=
SMMC7721 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXjjU3ExPzJiaILz NFrMRVFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPNUWM4PzJzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOy55IN88UU4> M3nRfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEe1NVU3Lz5{OUS3OVE2PjxxYU6=
MCF7 Mn;mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXzEb3l4PzJiaILz MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF6Lke1JO69VS5? NIPvTm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS3OVE2Pid-Mkm0O|UyPTZ:L3G+
MCF7 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NH3UTlQ1QCCqcoO= NU\QZXhHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU44QCEQvF2u NGS5VVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS4Olk2PCd-Mkm0PFY6PTR:L3G+
HCT116 NHf6XIFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnSwOFghcHK| MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuNlUh|ryPLh?= NIXBOHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS4Olk2PCd-Mkm0PFY6PTR:L3G+
A549 NV\1PGxISW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVy0PEBpenN? MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF7LkWyJO69VS5? NXTRXlk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PFY6PTRpPkK5OFg3QTV2PD;hQi=>
HepG2 MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4nhRVQ5KGi{cx?= M2DMd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKzMlYh|ryPLh?= MoTQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OE[5OVQoRjJ7NEi2PVU1RC:jPh?=
HeLa MWnDfZRwfG:6aXPpeJkh[XO|YYm= M1\kRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYomgUXRVKGG|c3H5MEBKSzVyIE2gNlgh|ryPLh?= NV20RWEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PFk{PjFpPkK5OFg6OzZzPD;hQi=>
A549 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2Mlgh|ryPLh?= M4S5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEi5N|YyLz5{OUS4PVM3OTxxYU6=
QSG7701 NXuyeopQSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mn3mNlQhcHK| MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFGVR{e3NFEh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gOk46OiEQvF2u M{HwXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEm5OFkxLz5{OUS5PVQ6ODxxYU6=
SMMC7721 MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkPkNlQhcHK| NVPXeYFCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjZoTldkAzPCCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzMj60O{DPxE1w MlrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OUm0PVAoRjJ7NEm5OFkxRC:jPh?=
QGY7703 NEXWbnVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4PEVlI1KGi{cx?= MoPNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCTR2m3O|A{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFE1NjJizszNMi=> NWnUOWd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PVk1QTBpPkK5OFk6PDlyPD;hQi=>
HepG2 NVLsN|NvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MofjNlQhcHK| M4PyO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNVUvPzRizszNMi=> M2nTbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEm5OFkxLz5{OUS5PVQ6ODxxYU6=
HL60 NX;kTJM4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGjLbpQ4OiCqcoO= NVrxdmEySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlM4KM7:TT6= NE\5SlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWyOFczQCd-Mkm1NlQ4Ojh:L3G+
Bel7402 NV\XOJJ2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mn7JO|IhcHK| NX;2XmdJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQC52OTFOwG0v M2XwdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUK0O|I5Lz5{OUWyOFczQDxxYU6=
PC3 NHXCNnFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3m5[FczKGi{cx?= Mmm5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|Lki2JO69VS5? NH7UXGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWyOFczQCd-Mkm1NlQ4Ojh:L3G+
MGC803 MnnERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEH6RpY4OiCqcoO= NF\reGxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPE43PiEQvF2u M3\jTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkO1NVY2Lz5{OU[zOVE3PTxxYU6=
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GES-1 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1nsNFczKGi{cx?= NVfM[GpxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHSXMuOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVIvPTFizszNMi=> NF;3Z2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[zOVE3PSd-Mkm2N|UyPjV:L3G+
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Bel7402 M4PtdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXjXSZdMPzJiaILz M4jNU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVgvQTdizszNMi=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ|NUG2PUc,Ojl4M{WxOlk9N2F-
SGC7901 NH3u[lBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3zKbVczKGi{cx?= MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOJQ{e5NFEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG5Mlg1KM7:TT6= NHzKVnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[zOVE3QSd-Mkm2N|UyPjl:L3G+
MCF7 M3HReGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3uz[FczKGi{cx?= M4TEN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uPVEh|ryPLh?= NVnHPGpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2N|UyPjlpPkK5OlM2OTZ7PD;hQi=>
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MDA-MB-231 NXnm[XpzS3m2b4TvfIlkcXS7IHHzd4F6 NYDVTlRzPDhiaILz MW\DfZRwfG:6aXPpeJkhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzVwOUGg{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3N{GwNEc,Ojl4NUexNFA9N2F-
DU145 NYHtR3NqS3m2b4TvfIlkcXS7IHHzd4F6 MWq0PEBpenN? NFHGNZpEgXSxdH;4bYNqfHliaX6gbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM6NjF5IN88UU4> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3N{GwNEc,Ojl4NUexNFA9N2F-
A549 NFfEVHBEgXSxdH;4bYNqfHliYYPzZZk> NXqzWGp6PDhiaILz NVflUHQ5S3m2b4TvfIlkcXS7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM6Njh4IN88UU4> NH7BVJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1O|ExOCd-Mkm2OVcyODB:L3G+
HepG2 M2LvZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4jE[FYh\GG7cx?= M3PaPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOiEQvF2u NGPoU5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe4OlQ{Pid-Mkm3PFY1OzZ:L3G+
SGC7901 MoLFR5l1d3SxeHnjbZR6KGG|c3H5 NVzTVFVXPiCmYYnz M3LhNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{IN88UU4> NW\4[IlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3PFY1OzZpPkK5O|g3PDN4PD;hQi=>
HepG2 M3PpfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPyEQvF2u MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd7OEiyOkc,Ojl5OUi4NlY9N2F-
HeLa NFX0SnRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M17xb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjhizszNMi=> M360UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{m4PFI3Lz5{OUe5PFgzPjxxYU6=
MCF7 M2DJbGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoLyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvQCEQvF2u M3K2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{m4PFI3Lz5{OUe5PFgzPjxxYU6=
COLO205 M2W0SmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEORTF:yNFUh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS57IN88UU4> NHn1bWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe5PFgzPid-Mkm3PVg5OjZ:L3G+
HEK293 MorSRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Ml\uRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKRVuyPVMh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwNjFOwG0v NWTNSJI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3PVg5OjZpPkK5O|k5QDJ4PD;hQi=>
A549 MmjXR5l1d3SxeHnjbZR6KGG|c3H5 NX7sRW1tS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTBiPTCzMlUzKM7:TT6= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh2M{GwN{c,Ojl6NEOxNFM9N2F-
HCT116 NVS3PHJ6S3m2b4TvfIlkcXS7IHHzd4F6 Mlv0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEWuOVMh|ryPLh?= NXjESlBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4OFMyODNpPkK5PFQ{OTB|PD;hQi=>
HeLa NGPJWWpEgXSxdH;4bYNqfHliYYPzZZk> NWG5dnFEPzJiaILz NWH3V41IS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNzFOwG0v NU\rTlZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFg1PDNpPkK5PVA5PDR|PD;hQi=>
McCoy MVrDfZRwfG:6aXPpeJkh[XO|YYm= MVy3NkBpenN? NH3HNVlEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBO[0OxeTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuO{DPxE1w NXn5SHpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFg1PDNpPkK5PVA5PDR|PD;hQi=>
PC3 M{Kyd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnXLOFghcHK| MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC52NTFOwG0v NXXXPXI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5OVg4PjNpPkK5PVU5PzZ|PD;hQi=>
HT-29 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2fXWFQ5KGi{cx?= NIPGe3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNk4zOyEQvF2u MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTl3OEe2N{c,Ojl7NUi3OlM9N2F-
HeLa NWfUc|N7S3m2b4TvfIlkcXS7IHHzd4F6 Ml:0OFghcHK| NUTjZoZvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzBwMkGg{txONg>? Mk[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByMEe1OlQoRjNyMEC3OVY1RC:jPh?=
HepG2 NXP1fJpzS3m2b4TvfIlkcXS7IHHzd4F6 MoPhOFghcHK| Mkf6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM3NjZ{IN88UU4> NH\iVY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECwO|U3PCd-M{CwNFc2PjR:L3G+
2008 MYjDfZRwfG:6aXPpeJkh[XO|YYm= M2f0b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFIxODhiY3XscJMtKEmFNUCgQUA3KM7:TT6= Mk\sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{W1OFEoRjNyMEO1OVQyRC:jPh?=
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DLD1 Ml[xRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUj0V3Q1PzJiaILz NYXEN4NKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzN{DPxE1w NFv5WGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECzO|Q6PCd-M{CwN|c1QTR:L3G+
CCD-841-CoN M4jiRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVW3NkBpenN? M4nId2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PEMVg1OS2Fb16gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN3Lkeg{txONg>? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB|N{S5OEc,OzByM{e0PVQ9N2F-
SKOV3 NYXINZNwS3m2b4TvfIlkcXS7IHHzd4F6 NIK0fVM1QCCqcoO= M3T4dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPi5|NDFOwG0v MlfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUKzOlgoRjNyMEmyN|Y5RC:jPh?=
HepG2 M3PoeGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{DMR|Q5KGi{cx?= NWqyV2Y{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNzLkm4JO69VS5? Mmr1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUKzOlgoRjNyMEmyN|Y5RC:jPh?=
Bel7404 NVTCfXdFS3m2b4TvfIlkcXS7IHHzd4F6 MVe0PEBpenN? NX\SblVsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSmWuN{SwOEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNECuNlEh|ryPLh?= MlLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUKzOlgoRjNyMEmyN|Y5RC:jPh?=
NCI-H460 NUCwepZSS3m2b4TvfIlkcXS7IHHzd4F6 NUXXdVU2PDhiaILz M2K4ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2NT60OEDPxE1w NYXhTZVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVI{PjhpPkOwNFkzOzZ6PD;hQi=>
RKO Mor6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF:4bFA1QCCqcoO= MmntS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVmtQKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFExNjJizszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODFyNkK4PUc,OzBzME[yPFk9N2F-
LoVo NHvzUGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4i3PVQ5KGi{cx?= M3rQ[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGxwXm9iY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTFwNTFOwG0v NVy5NFRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNFYzQDlpPkOwNVA3Ojh7PD;hQi=>
MCF7 NGDq[IRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHnZOZg4OiCqcoO= MkLERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nj6xOEDPxE1w MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF2Mk[xNkc,OzBzNEK2NVI9N2F-
MGC803 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYm3NkBpenN? NEXaWYRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|EvODRizszNMi=> NYPsZVdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOFI3OTJpPkOwNVQzPjF{PD;hQi=>
HCT116 NIi2fIJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV3HXpc4PzJiaILz MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{iuN{DPxE1w MlftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEK2NVIoRjNyMUSyOlEzRC:jPh?=
HepG2 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn22O|IhcHK| MoXRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEeuPVch|ryPLh?= NHH6RY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG0NlYyOid-M{CxOFI3OTJ:L3G+
A549 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYnwUpNFPzJiaILz NV:2d4RYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlA2KM7:TT6= M{HiTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkSzNVU{Lz5|MEK0N|E2OzxxYU6=
Bel7402 NXzaR3ozSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV:3NkBpenN? NX\3[JJjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQC54NTFOwG0v MnLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEOxOVMoRjNyMkSzNVU{RC:jPh?=
MCF7 MmP2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYm4bZVYPzJiaILz MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5Lki5JO69VS5? NWTPVWplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyOFMyPTNpPkOwNlQ{OTV|PD;hQi=>
T84 M1LwT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NI\BR5Y{KGSjeYO= MmX5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWOESgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTCzMlQh|ryPLh?= NFzlZnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0PFY2Pyd-M{CyOFg3PTd:L3G+
A549 M3;oRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoTvN{Bl[Xm| M2ixd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB|IHThfZMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFcvOSEQvF2u MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ2OE[1O{c,OzB{NEi2OVc9N2F-
MCF7 NYnBWYdmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mk\SN{Bl[Xm| NELMfIVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMzDkZZl{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUA4NjhizszNMi=> NITvfFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0PFY2Pyd-M{CyOFg3PTd:L3G+
A549 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NV\CSY5lPzJiaILz NIfCOJJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1NjNizszNMi=> MnP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|MUi0OFAoRjNyM{G4OFQxRC:jPh?=
HeLa NVvTe|RmS3m2b4TvfIlkcXS7IHHzd4F6 MnjQO|IhcHK| M33PXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjd3IN88UU4> MnfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|MUi0OFAoRjNyM{G4OFQxRC:jPh?=
HCT116 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MojZO|IhcHK| M{L1PWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwNU[g{txONg>? NUizUWVSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVg1PDBpPkOwN|E5PDRyPD;hQi=>
NCI-H460 MmjrR5l1d3SxeHnjbZR6KGG|c3H5 M{nNO|czKGi{cx?= NX\hfFVbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGxMlc2KM7:TT6= M2L0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G4OFQxLz5|MEOxPFQ1ODxxYU6=
HCT15 NGfXS5FEgXSxdH;4bYNqfHliYYPzZZk> MUC3NkBpenN? M4qwOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDF3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS56NzFOwG0v M{nRdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G4OFQxLz5|MEOxPFQ1ODxxYU6=
MDA-MB-231 NH7QNYpEgXSxdH;4bYNqfHliYYPzZZk> MofWO|IhcHK| NWjITGdIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlEvODVizszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODNzOES0NEc,OzB|MUi0OFA9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / PUMA / c-PARP; 

PubMed: 25965911     


(A) HCT-116 cells were treated with various doses of 5-FU for 24 hours (B) HCT-116 cells were treated with 200 uM 5-FU, then harvested at different time points after stimulation. The expression of p53, PUMA, cleaved PARP and P-Akt(S473) were detected by western blotting in different conditions.

25965911
Immunofluorescence
caveolin-3; 

PubMed: 23646193     


Cells were stained with an antibody against caveolin-3 (green) and with DAPI (blue). (A) control cells (top images), 10 mM 5-FU (middle images), 50 mM 5-FU (bottom images). Merged images are shown at the right of each panel.

phospho-histone H3 ; 

PubMed: 23646193     


Cells were grown for 24 h, treated with 5-FU and stained with an anti-phospho-histone H3 antibody (red) and with DAPI (blue). (A) control cells, (B) 0.1 mM 5-FU and (C) 1 mM 5-FU. 

p65 / p-p65(Ser536) / p53 / p-p53(Ser15); 

PubMed: 24587255     


E–H, Immunocytochemistry of p65 and p53 induction and localization by 5-FU treatment for the indicated cell lines. p65 (red), phosphor-p65 (Ser536; red), p53 (green), phospho-p53 (Ser15; red), and DAPI (blue) staining of the nucleus without (control) and with 5-FU treatment. 

Sox2 / Oct4 / Nanog / ABCG2; 

PubMed: 27009861     


(A) Immunofluorescence staining of Sox2, Oct4 and Nanog in HBE cells with or without 5-FU treatment. In untreated HBE cells, few Sox2, Oct4 or Nanog-positive cells were observed. After 5-FU treatment, the number of Sox2, Oct4 or Nanog-positive cells increased remarkably. Nuclei were counterstained with DAPI (blue). (B) Immunofluorescence staining of ABCG2 in HBE cells with or without 5-FU treatment. 

β-catenin; 

PubMed: 30111797     


Immunofluorescence detection of β-catenin in HCT-8 cells. Scale bar, 20 μm.

non-phospho β-catenin; 

PubMed: 28588704     


Effect of enhanced WNT signaling in Ell3 OE cells. Localization of non-phosphorylated β-catenin was analyzed by immunocytochemical staining in (A) control MCF-7 and (B) Ell3 OE treated with various 5-FU concentrations.

23646193 24587255 27009861 30111797 28588704
Growth inhibition assay
Cell viability; 

PubMed: 25965911     


Cells viability was analyzed using Cell Counting Kit-8 at 0, 3, 6, 12 and 24 hours after (A) 50, 100, 200, or 400 uM 5-FU treatment in HCT116 cells.

Cell proliferation; 

PubMed: 30250641     


(A) Cell proliferation assay with resveratrol in HCT116. Cells were treated with resveratrol at 0 ~ 200 μM for 72 hours and applied to MTS assay. (B) HCT116 cells were treated with 5-FU at 0~200 μM for 72 hours. (C)HCT116 cells were treated with resveratrol at 0 ~ 200 μM combined with 5-FU at 10 μM for 72 hours and applied to MTS assay. (D) DLD1 cell proliferation assay with resveratrol at 0 ~ 200 μM for 72 hours. (E) DLD1 cells were treated with 5-FU at 0~ 200 μM for 72 hours. (F) DLD1 cells were treated with resveratrol combined with 5-FU at 10 μM for 72 hours. Error bars represent standard deviation.

25965911 30250641
In vivo Adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. [1] 100mg/kg Adrucil significantly suppresses tumor growth of murine colon carcinomas Colon 38 with tumor-doubling time (TD), growth-delay factor (GDF), and T/C of 26.5 days, 4.4, and 14%. [5]

Protocol

Cell Research:[4]
- Collapse
  • Cell lines: Human colon carcinoma cell line HT-29
  • Concentrations: ~25 μM
  • Incubation Time: 7 days
  • Method: Growth inhibition is measured after treatment of cells with Adrucil for 7 days in 96-well plates (4000 HT-29 cells/well in RPMI 1640 medium with 10% dialyzed fetal bovine serum); increasing concentrations of Adrucil are added after allowing for cell attachment overnight. At the end of incubation, cells are rinsed three times with phosphate-buffered saline (pH 7.4), fixed with 10% trichloroacetic acid for 60 min at 4 ℃, washed five times with deionized water, and stained with 0.4% sulforhoda-mine B solution for 15 min at room temperature. Unstained sulforhodamine B is removed by rinsing with 1% glacial acetic acid. Afterwards, stained cell proteins are dried and dissolved with 10 mM Tris-HCl. The optical density value is measured using a detector at 540 nm wavelength.
    (Only for Reference)
Animal Research:[5]
- Collapse
  • Animal Models: Murine colon carcinomas Colon 38
  • Dosages: 100 mg/kg
  • Administration: i.p. weekly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 26 mg/mL (199.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
saline (warming)
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 130.08
Formula

C4H3FN2O2

CAS No. 51-21-8
Storage powder
in solvent
Synonyms NSC 19893
Smiles C1=C(C(=O)NC(=O)N1)F

In vivo Formulation Calculator (Clear solution)

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molecular Weight Calculator

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04158349 Recruiting Drug: Oxaliplatin|Drug: mFOLFIRI Colorectal Cancer|Appendiceal Cancer|Peritoneal Carcinoma University of Utah June 11 2020 Phase 1
NCT04370418 Not yet recruiting Drug: short course chemo-radiation with 5-fluorouracil Neo-adjuvant Short Course Chemo-radiation in Locally Advanced Cancer Rectum Assiut University May 2020 --
NCT04274933 Terminated Drug: Venetoclax|Drug: Capecitabine Breast Cancer|Cancer AbbVie May 21 2020 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    I was wondering if the product #s1209 (5-fluorouracil) is suitable to inject into mice ?

  • Answer:

    S1209 is suitable to inject (I.P.) into mice as indicating in this paper: http://www.ncbi.nlm.nih.gov/pubmed/8995503.

DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID