Fluorouracil (5-Fluorouracil, 5-FU)

For research use only.

Catalog No.S1209 Synonyms: NSC 19893

122 publications

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

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Selleck's Fluorouracil (5-Fluorouracil, 5-FU) has been cited by 122 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Targets
Thymidylate synthase [1]
(Tumor cells)
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7pemU4OsLiaNMg NGTZb3JKSzVyPjCyOUDPxGdxbVy= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
HL-60 MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT0O|LDqGkEoB?= M{jx[GlEPTB;OD62NFEh|rypL33M NYP2fVQ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HT-29 NXHxTGIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn3O|LDqGkEoB?= MXTJR|UxRiB{NTFOwIcwdUx? NGfpbYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
MCF-7 M2jZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS3NuKhcMLi M4HJNWlEPTB;MkCg{txoN22O M3\5RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
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CCRF-CEM NV\6[o4{TnWwY4Tpc44h[XO|YYm= M33z[GVn\mWldDDvckBES1KILVPFUUBk\WyuczDpckBkfWy2dYLlMEBKSzVyIE2gNkDPxE1w M2ixVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkKyO|goRjJ|NkKyO|g9N2F-
P388 NV\sbWlbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYPKbndpPDhiaILz M37JUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUEO4PEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD62NFkh|ryPLh?= NGTFdIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e4OFQ6Lz5{N{e4OFQ6RC:jPh?=
HT-29 M4nOPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF25c|g6PiCqcoO= M361cmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlkh|ryPLh?= NVTE[4R7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3PFQ1QSd-Mke3PFQ1QTxxYU6=
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SW480 NEjyWlJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVy0SJdGPzJiaILz MmLPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEiuNUDPxE1w NV3GepV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NlQ3PTVpPkG3OVI1PjV3PD;hQi=>
MDA-MB-435S MYHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGT0To44OiCqcoO= MlrhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDN3UzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NEA:KDF2LkWg{txONg>? NUXqWW8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NlQ3PTVpPkG3OVI1PjV3PD;hQi=>
HCCLM7 MoraRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1HqXlczKGi{cx?= NHnHdIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDR2xOPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFE5NjZizszNMi=> M4\2fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUK0OlU2Lz5zN{WyOFY2PTxxYU6=
Caco-2 NEDXSGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEH5R2tIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBE[WOxLUKgZ4VtdHNuIFnDOVAhRSBzLkWg{txONg>? Mm[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixNlkoRjF5NUS4NVI6RC:jPh?=
MCF7 MluwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mny1O|IhcHK| MkLiRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{whUUN3MDC9JFAvOyEQvF2u NIX1fIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
HCT116 NXfhdJlFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUnMfnptPzJiaILz MmnyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hOi56IN88UU4> M2Hu[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUS4NVk5Lz5zN{W0PFE6QDxxYU6=
SW480 NUGyNId7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYO3NkBpenN? MlTKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4NEBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUA{NjVizszNMi=> NGTHSYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
SW48 NGPhWpFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mo[zO|IhcHK| MlHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4JINmdGy|IHHmeIVzKDd{IHjyd{whUUN3MDC9JFUvOyEQvF2u MoTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixPVgoRjF5NUS4NVk5RC:jPh?=
DLD1 NGTqUFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVnX[IhpT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTEyGMTDj[YxteyxiSVO1NEA:KDRwNTFOwG0v NWnQNFFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVM3QDVpPkG3OVU{Pjh3PD;hQi=>
Caco-2 M1nkeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmH5NVAh\GG7cx?= MmHKS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR4Fkdy1{IHPlcIx{KGGodHXyJFExKGSjeYOsJGlEPTBiPTCxMlUh|ryPLh?= MmLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUW5OlkoRjF5NUW1PVY6RC:jPh?=
colon cancer cell MoK3R5l1d3SxeHnjbZR6KGG|c3H5 MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOsJGdKPTBiPTC1Mlc2KM7:TT6= MoXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkKzOlUoRjF5NU[yN|Y2RC:jPh?=
A549 NX\MUVRwS3m2b4TvfIlkcXS7IHHzd4F6 NV7YT5JFPDhiaILz NYfhZnhtS3m2b4TvfIlkcXS7IHHnZYlve3RiQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6yJO69VS5? MlLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MESzPVQoRjF5NkC0N|k1RC:jPh?=
L1210 M3\nN2N6fG:|dHH0bYMh[WO2aY\peJkh[XO|YYm= MXLDfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOsJGlEPTBiPTCwMlI5KM7:TT6= M2TobFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUOxPFYzLz5zN{mzNVg3OjxxYU6=
CEM NHfDXXFEgXSxc4TheIlkKGGldHn2bZR6KGG|c3H5 MXTDfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1XNJINmdGy|LDDJR|UxKD1iOTFOwG0v NFPPOWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mzNVg3Oid-MUe5N|E5PjJ:L3G+
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Caco-2 M1\xRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWixNEBl[Xm| Mm\wS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR4Fkdy1{IHPlcIx{KGGodHXyJFExKGSjeYOsJGlEPTBiPTCxMlUh|ryPLh?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB|N{G5OUc,OThyM{exPVU9N2F-
MCF7 NHGyPYJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmjnN{Bl[Xm| M4C1[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB|IHThfZMh[nliU2LCJIF{e2G7LDDJR|UxKD1iND6zNkDPxE1w MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB4OUC5N{c,OThyNkmwPVM9N2F-
MCF7 NIPpRVdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYjuSmNnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gOE4{OiEQvF2u MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDF7NEi2Okc,OThzOUS4OlY9N2F-
embryonic cell MlOySpVv[3Srb36gZZN{[Xl? M2\CVWlv\HWldHnvckBw\iClbHXheoFo\SCjcoLld5QhcW5iZX3idplwdmmlIHPlcIx{KG:oIIP0ZYdmKDhiWHXuc5B2eyCuYXX2bZMh[myjc4T1cIFmNCCLQ{WwJF0hOjZwODFOwG0v MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MUW1PEc,OTh{N{G1OVg9N2F-
HepG2 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NX30W|hjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSBzOD63JO69VS5? NWjnbVRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFI{OzZpPkG4N|AzOzN4PD;hQi=>
L1210 NF;WdoFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVzkNVJqOiCmYYnz NX;qdXNCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{Bi\nSncjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE43QSEQvF2u NGnxboI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESyOFE2PSd-MUi0NlQyPTV:L3G+
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HepG2 MlHTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFTNVGQ{KGSjeYO= NHnFZlBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlIh|ryPLh?= NH;EenA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESyOFE2PSd-MUi0NlQyPTV:L3G+
CEM Ml;WRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3TjblMh\GG7cx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOHTTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5{MzFOwG0v Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
WI38 M1rXOmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHnXUXY{KGSjeYO= NEDEXoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUTN6IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOCEQvF2u MnqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
HeLa MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3;HPVMh\GG7cx?= NHv5cYZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2JO69VS5? MlLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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LLC MmXTR5l1d3SxeHnjbZR6KGG|c3H5 NGjKUXQ4OiCqcoO= M4PJdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGxNSyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk42QSEQvF2u M3q3blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESwNlM{Lz5zOES0NFI{OzxxYU6=
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UACC257 MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYW0PEBpenN? MYfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVRWNEOjV5IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMz61OFgyOyEQvF2u MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
SNB19 NXXzU5NkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn;IOFghcHK| M{XqXGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNPSjF7IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMz64NFE5QSEQvF2u NHzU[og9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
OVCAR4 M3zwVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmH4OFghcHK| M3XxZmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUNDDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IESuOFY3QDRizszNMi=> NYixeodYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
MDA-MB-231 MkfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYS2XG57PDhiaILz MUnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gOk43ODZ7MzFOwG0v NICzNW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
NCI-H522 MmnjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVq0PEBpenN? NEm0TG1Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNkBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFcvOjR2M{[g{txONg>? NV\ocnh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
T47D NG[2Z2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DmPVQ5KGi{cx?= NFnGTpNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOD6xNlg{OSEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
CCRF-CEM MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYm0PEBpenN? NWXiS4czT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUA6Njd5MkO3JO69VS5? MkD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
Hs 578T NWDOXIg6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3i3[VQ5KGi{cx?= MWHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDId{A2PziWIHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOT63O|I{PyEQvF2u M1LxcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
BT549 MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DMblQ5KGi{cx?= MVTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDCWFU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDFyLkexOVIh|ryPLh?= M2jDXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
OVCAR5 M2HSNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFqyUWI1QCCqcoO= NXTySHgyT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWK1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gNVAvQTZ2ODFOwG0v NVHFT45{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
SKOV3 MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWixRpExPDhiaILz NIXqUFRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUU0:YMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEKxMlg4PzZizszNMi=> NXjUWW9wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
HCT116 NFfSS5pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1vDd|czKGi{cx?= NWnh[HptSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh\XiycnXzd4lv\yCyNUOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8h[XO|YYmsJGlEPTBiPTCxNkDPxE1w M{W3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEezO|QxLz5{MEi3N|c1ODxxYU6=
A2780 M3H5cGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mke1O|IhcHK| MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IHX4dJJme3OrbnegdFU{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=> NHHxXoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
U2OS NH\vbI1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkL6O|IhcHK| NHrDSWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGWyU3Mh[2WubIOg[ZhxemW|c3nu[{BxPTNiYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:gZZN{[XluIFnDOVAhRSBzNjFOwG0v NFP1bpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
p53 deficient PC3 M3Pvd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWS3NkBpenN? Mn7HRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyNUOg[IVncWOrZX70JHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdyCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NFvFdI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
SF539 M3LLNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF;k[Jk4OiCqcoO= NYPXfXhrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTSlU{QSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{Bie3OjeTygTWM2OCB;IESzJO69VS5? MmPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6N{O3OFAoRjJyOEezO|QxRC:jPh?=
HCT15 NInKVYJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mn;ZO|IhcHK| MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEG1JINmdGy|IHX4dJJme3OrbnegdFU{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHHzd4F6NCCLQ{WwJF0hPDhizszNMi=> NUK5TnJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
T3M4 M1GwVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGnnWFVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVO012IHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOC5|MzFOwG0v Mne4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
Colo-357 NGTtd4JEgXSxdH;4bYNqfHliYYPzZZk> NGjvdZNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEd2yxLUO1O{Bk\WyuczDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzygTWM2OCB;IEKuNFUh|ryPLh?= NGfLUXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-T MWXDfZRwfG:6aXPpeJkh[XO|YYm= NED5WZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBR[XS3LWSgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB{LkC4JO69VS5? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Patu-S MYTDfZRwfG:6aXPpeJkh[XO|YYm= MnnOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2VIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOi57MzFOwG0v NIi1O|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Aspc-1 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NHrD[4VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCe3ClLUGgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB{Lkm3JO69VS5? MmrNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
PANC1 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M13CPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBCVkNzIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOy57NDFOwG0v NGTCT489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-02 M3nJdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQZZR2NTB{IHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOy57NTFOwG0v MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
DAN-G M3LsN2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3XCWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRCVi2JIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hPC5|ODFOwG0v MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Patu-T MYfDfZRwfG:6aXPpeJkh[XO|YYm= NXm2RXEzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPS2IVT3y[ZNqe3SjboSgVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOzNwMjFOwG0v NXTGeIR4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
Hep2 Ml7YRY51cWOjbnPldkBie3OjeR?= M4TxfFQ5KGi{cx?= MXrBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMD6zJO69VS5? NVP6N4hxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
A549 M4rzXmFvfGmlYX7j[ZIh[XO|YYm= MlS0OFghcHK| M{nhNmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlQh|ryPLh?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
HCT15 MlfrRY51cWOjbnPldkBie3OjeR?= Mke1OFghcHK| MVPBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVUh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEOuOkDPxE1w MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
502713 NXHGXGhHSW62aXPhcoNmeiCjc4PhfS=> NVfENGNkPDhiaILz M1XhXWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjC1NFI4OTNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvPiEQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
DU145 M1\UOmFvfGmlYX7j[ZIh[XO|YYm= M3HsOFQ5KGi{cx?= NXjXXVVPSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA1NjhizszNMi=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
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HepG2 MXzDfZRwfG:6aXPpeJkh[XO|YYm= NYDRfm83OyCmYYnz NXXMfIxjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwNzFOwG0v M{D2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwPVI2Lz5{MkCwNFkzPTxxYU6=
BCG823 NVvD[4FsS3m2b4TvfIlkcXS7IHHzd4F6 NGDKUpI{KGSjeYO= NHjKeIJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS0d6MkOgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwMUWg{txONg>? MonEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMEC5NlUoRjJ{MECwPVI2RC:jPh?=
colon cancer cell NXvUfGRXS3m2b4TvfIlkcXS7IHHzd4F6 MojHOFghcHK| M3fmcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgZ492dHSncjDjc5VvfGmwZzygS2k2OCB;IEiuOEDPxE1w MmTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNU[yO|coRjJ{MEW2Nlc4RC:jPh?=
leukemia cell MWrDfZRwfG:6aXPpeJkh[XO|YYm= MV:0PEBpenN? MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjZoTldkA1QCCqcoOgZpkh[2:3bITldkBkd3WwdHnu[{whT0l3MDC9JFE2NjFizszNMi=> NGC4Tlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC1OlI4Pyd-MkKwOVYzPzd:L3G+
prostate cancer cell NFLrOI1EgXSxdH;4bYNqfHliYYPzZZk> MY[0PEBpenN? MljYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62aX7nMEBIUTVyIE2gNlIvPyEQvF2u MmHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNU[yO|coRjJ{MEW2Nlc4RC:jPh?=
renal cancer cell Mn\4R5l1d3SxeHnjbZR6KGG|c3H5 M3fCflQ5KGi{cx?= NWTPNJhGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62aX7nMEBIUTVyIE2gOFUvPiEQvF2u MnvxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNU[yO|coRjJ{MEW2Nlc4RC:jPh?=
MCF7 NEfrNWtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NX;iU452PzJiaILz NHu4dnNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuOlch|ryPLh?= NW\xfHFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwO|k{PzhpPkKyNFc6Ozd6PD;hQi=>
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GLC82 MVPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmnNO|IhcHK| NYrKd2F6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHUGM5OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPSEQvF2u NHz2VWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC3PVM4QCd-MkKwO|k{Pzh:L3G+
MGC803 M4O2[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIDVU3Q4OiCqcoO= MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uOkDPxE1w MkjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzO|goRjJ{MEe5N|c5RC:jPh?=
CNE2 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGfDZ5k4OiCqcoO= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOQRUKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5LkKg{txONg>? MnT0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzO|goRjJ{MEe5N|c5RC:jPh?=
HEK293 MV3DfZRwfG:6aXPpeJkh[XO|YYm= MVmyJIRigXN? NInEWG5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJTUt{OUOgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwJF0hPDJwOTFOwG0v NFnScYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5N|c3OSd-MkKwPVM4PjF:L3G+
colon cancer cell NVnJOlVYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofZOFghcHK| MoXnS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCJSUWwJF0hQC52IN88UU4> M3ruNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUG5NVUyLz5{MkGxPVE2OTxxYU6=
leukemia cell MonpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYG0PEBpenN? NVnqeYZwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUAyPS5zIN88UU4> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUG1NUc,OjJzMUmxOVE9N2F-
prostate cancer cell NUO1fWFqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2HFOFQ5KGi{cx?= MmXUS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62ZYKgcYV1cG:mLDDHTVUxKD1iMkKuO{DPxE1w MmTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUmxOVEoRjJ{MUG5NVUyRC:jPh?=
renal cancer cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmLZOFghcHK| NHKx[5hIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINwfWy2ZYKgZ492dnSncjDt[ZRpd2RuIFfJOVAhRSB2NT62JO69VS5? NH\FcHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVE2OSd-MkKxNVkyPTF:L3G+
H460 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NFXa[JE4OiCqcoO= NFzkeFJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPDZyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{KM7:TT6= NGHq[oI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oid-MkKxN|AyOzJ:L3G+
HCT116 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NUDQfGt2PzJiaILz MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQh|ryPLh?= NFTpXoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oid-MkKxN|AyOzJ:L3G+
MCF7 NHfYcYFEgXSxdH;4bYNqfHliYYPzZZk> MWW3NkBpenN? NVX2SI5uS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=> NG\KXHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oid-MkKxN|AyOzJ:L3G+
A549 MoDzR5l1d3SxeHnjbZR6KGG|c3H5 MXqyOEBpenN? MlT1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU43PCEQvF2u NEjLSG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG4NlkzPid-MkKxPFI6OjZ:L3G+
QGY7701 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MXyyOEBpenN? NIfsXW1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBST1l5N{CxJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND6zJO69VS5? M2Ll[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUiyPVI3Lz5{MkG4NlkzPjxxYU6=
SW480 MmiwR5l1d3SxeHnjbZR6KGG|c3H5 MnXUNlQhcHK| NVvLfJVFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d2OECgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkexJO69VS5? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF6MkmyOkc,OjJzOEK5NlY9N2F-
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KB MoTwR5l1d3SxeHnjbZR6KGG|c3H5 MmT4O|IhcHK| M322PWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCweTDNWHQh[XO|YYmsJGlEPTBiPTC5JO69VS5? NVjIT|FHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNFA1ODRpPkKyNlAxPDB2PD;hQi=>
CNE2 NWTzWoJsS3m2b4TvfIlkcXS7IHHzd4F6 M1rUSFczKGi{cx?= M2fSXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPTTJiY3XscJMh[W[2ZYKgO|IhcHK|IH75JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjVizszNMi=> M1rSOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkCwOFA1Lz5{MkKwNFQxPDxxYU6=
HepG2 Mln1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Moe3OFghcHK| NHnHboVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU46OiEQvF2u NI\BfIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwPVQ5Pid-MkKyNFk1QDZ:L3G+
NCI-H460 NH\2XodEgXSxdH;4bYNqfHliYYPzZZk> MnLyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNuIFnDOVAhRSB6IN88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{S1NUc,OjJ{OEO0OVE9N2F-
SMMC7721 NUPkVoY5S3m2b4TvfIlkcXS7IHHzd4F6 MmLVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNuIFnDOVAhRSBzNTFOwG0v Mlv3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0OVEoRjJ{MkizOFUyRC:jPh?=
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leukemia NIrsdnNEgXSxdH;4bYNqfHliYYPzZZk> M1uwPFQ5KGi{cx?= MnPlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bIDoc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gNVUvOSEQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR5NEi5PUc,OjN2N{S4PVk9N2F-
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HepG2 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MmDLOFghcHK| MlzpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIzNjhizszNMi=> NWfz[INTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVAyPTlpPkKzOFkxOTV7PD;hQi=>
SGC7901 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NYroWZp4PDhiaILz NWDVT5VzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuPUDPxE1w M{DxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEmwNVU6Lz5{M{S5NFE2QTxxYU6=
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HepG2 NGi4SnFEgXSxdH;4bYNqfHliYYPzZZk> M2C3c|Q5KGi{cx?= MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFAvOzRizszNMi=> NVfHdWRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
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MCF7 M1nHbGN6fG:2b4jpZ4l1gSCjc4PhfS=> NX;IXG1XPzJiaILz MojJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4{OyEQvF2u M{DwOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NVk{Lz5{M{[0OFE6OzxxYU6=
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HCT116 M3nVcGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHfLRY04OiCqcoO= NWT2T5M2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFUvPTNizszNMi=> NV3veZo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OlUyODZpPkKzOlY2OTB4PD;hQi=>
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prostate cancer M3PxSmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4jNfFQ5KGi{cx?= MoG4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62ZYKgZY5idHm|aYOsJGdKPTBiPTCyNk44KM7:TT6= NWDpfW9qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
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SH-SY5Y MV;DfZRwfG:6aXPpeJkh[XO|YYm= NVjJ[5NoPzJiaILz MlqwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2guW1l3WTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC57NzFOwG0v Mn3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
HCT116 MoPuR5l1d3SxeHnjbZR6KGG|c3H5 MmnuO|IhcHK| MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvOjRizszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6NUW3NUc,OjN4OEW1O|E9N2F-
A549 M1nLNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlS4O|IhcHK| M4HOeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvPzFizszNMi=> M4rYR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nki1OVcyLz5{M{[4OVU4OTxxYU6=
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HepG2 M4HqO2N6fG:2b4jpZ4l1gSCjc4PhfS=> NULpR2xPPzJiaILz M{Xrd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC57NjFOwG0v NIDoOIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU4OSd-MkO2PFU2PzF:L3G+
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BT549 NYLBbGJGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWraOWJIPDhiaILz Mn7jS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD62JO69VS5? NWj5WXdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFcxPTVpPkKzPFg4ODV3PD;hQi=>
OVCAR5 NGrsOFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrFXHZSPDhiaILz M2TYNWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUNTDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEGwMlkh|ryPLh?= NEftWlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i4O|A2PSd-MkO4PFcxPTV:L3G+
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MDA-MB-231 M3\GR2N6fG:2b4jpZ4l1gSCjc4PhfS=> NV7LNJZbPDhiaILz M2[2UGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGzMlY2KM7:TT6= MkLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MkCyOFYoRjJ|OUKwNlQ3RC:jPh?=
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A549 MWfDfZRwfG:6aXPpeJkh[XO|YYm= M365Z|czKGi{cx?= M4HJdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFMvPiEQvF2u M4PDdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[0Olc4Lz5{M{m2OFY4PzxxYU6=
SKOV3 NXLMSZNpS3m2b4TvfIlkcXS7IHHzd4F6 MWW0PEBpenN? NG\yV49EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwNEOg{txONg>? NUXuTY9TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
HepG2 M3q1Z2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIXmPFQ1QCCqcoO= MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlkvQThizszNMi=> NX7jZ3RjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
A549 MmfzR5l1d3SxeHnjbZR6KGG|c3H5 MlHWOFghcHK| NF7ub49EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{PC5|MzFOwG0v NFfFOmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m4PFM2Pyd-MkO5PFg{PTd:L3G+
NCI-H460 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MVe0PEBpenN? M2\DUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2ND6wOEDPxE1w NVfE[|V4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PFg{PTdpPkKzPVg5OzV5PD;hQi=>
leukemia NUnPdlFmS3m2b4TvfIlkcXS7IHHzd4F6 MXu0PEBpenN? NI\OOnZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMT61NUDPxE1w MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7NEOyPEc,OjN7OUSzNlg9N2F-
colon cancer NULLfY5mS3m2b4TvfIlkcXS7IHHzd4F6 NFTOVI01QCCqcoO= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEiuOEDPxE1w NITrdms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5OFMzQCd-MkO5PVQ{Ojh:L3G+
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renal cancer MYHDfZRwfG:6aXPpeJkh[XO|YYm= NX3DblVSPDhiaILz NELrXZdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFQ2NjZizszNMi=> M37BRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUm0N|I5Lz5{M{m5OFMzQDxxYU6=
A375-S2 NGjScG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\1OFghcHK| M2PDUmdzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iQUO3OU1UOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk43PyEQvF2u NFjTXmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1Pid-MkO5PVkxPDZ:L3G+
HeLa MmHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVr2fY9GPDhiaILz MnznS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkO0JO69VS5? MlrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFYoRjJ|OUm5NFQ3RC:jPh?=
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MCF7 MnTkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{SwOFQ5KGi{cx?= M3XtRmdzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUGuOUDPxE1w MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0Okc,OjN7OUmwOFY9N2F-
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HCT116 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1fENVQ5KGi{cx?= NXPIUHExT3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4Njd4IN88UU4> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0Okc,OjN7OUmwOFY9N2F-
HT1080 MmK5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVvNRWQ{PDhiaILz NULuOodNT3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM2NjZ{IN88UU4> MlHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFYoRjJ|OUm5NFQ3RC:jPh?=
HepG2 NX;BbXJZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mof1OFghcHK| Mny5S5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNECuN|Qh|ryPLh?= MoLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFYoRjJ|OUm5NFQ3RC:jPh?=
A549 MlqyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnXCOFghcHK| MnzjS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2ND6wOUDPxE1w NXq2OXN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDZpPkKzPVk6ODR4PD;hQi=>
QSG7701 NGqwfoVEgXSxdH;4bYNqfHliYYPzZZk> NYPhZ2lEPDhiaILz M1zNdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFUTzd5MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMD62JO69VS5? M{jyO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGzOFE2Lz5{NECxN|QyPTxxYU6=
HepG2 Mn\FR5l1d3SxeHnjbZR6KGG|c3H5 MUO0PEBpenN? M{X2ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkS4JO69VS5? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzM{SxOUc,OjRyMUO0NVU9N2F-
SMMC7721 NVKxOW9oS3m2b4TvfIlkcXS7IHHzd4F6 NUTUc3RlPDhiaILz MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzND61OUDPxE1w M1XHUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGzOFE2Lz5{NECxN|QyPTxxYU6=
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Hep MXrDfZRwfG:6aXPpeJkh[XO|YYm= M{[2WlQ5KGi{cx?= M2LtWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= NInDUGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC1OlE1Pid-MkSwOVYyPDZ:L3G+
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A549 MYLDfZRwfG:6aXPpeJkh[XO|YYm= M33tV|I1KGi{cx?= NITM[GREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjFizszNMi=> M1X4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2ME[wOFg3Lz5{NEC2NFQ5PjxxYU6=
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MCF7 M2fyfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIHre|UzPCCqcoO= M1qz[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvOiEQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4MES4Okc,OjRyNkC0PFY9N2F-
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MCF7 NV3GXG9KS3m2b4TvfIlkcXS7IHHzd4F6 Mnn4O|IhcHK| NFLqdG1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkW0JO69VS5? NWOzR3BzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwO|cyQDJpPkK0NFc4OTh{PD;hQi=>
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Bel7402 NHfCXXBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEi0U3BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD6zJO69VS5? M3TmUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NFk1Lz5{NEC5OVA6PDxxYU6=
A549 M2jZc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml\DRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvQTJizszNMi=> NI\mfZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVA6PCd-MkSwPVUxQTR:L3G+
SKOV3 M{HsfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nrVlMh\GG7cx?= Ml\3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjR|IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe0OUc,OjRyOUW3OFU9N2F-
HepG2 NU\sU5RSS3m2b4TvfIlkcXS7IHHzd4F6 MYqzJIRigXN? Mme0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI6Njl6IN88UU4> NWnLU|J2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PDVpPkK0NFk2PzR3PD;hQi=>
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NCI-H460 MlS2R5l1d3SxeHnjbZR6KGG|c3H5 MkLuN{Bl[Xm| NV7S[ZR1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IES0MlA1KM7:TT6= NXjsU|hGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PDVpPkK0NFk2PzR3PD;hQi=>
MGC803 NIHXO2hEgXSxdH;4bYNqfHliYYPzZZk> NIDvcWk1QCCqcoO= NWrJZ2pCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Lk[4JO69VS5? NIDENpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVg3QSd-MkSxNVk5Pjl:L3G+
HepG2 NEDqfnJEgXSxdH;4bYNqfHliYYPzZZk> NYLabG5SPDhiaILz NFvmR3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC5|NTFOwG0v MmPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUm4OlkoRjJ2MUG5PFY6RC:jPh?=
Bcap37 M13qNGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnPWOFghcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCZ4FxOzdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFUvPThizszNMi=> M2jZdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5PFY6Lz5{NEGxPVg3QTxxYU6=
SGC7901 NX;hbpVPS3m2b4TvfIlkcXS7IHHzd4F6 NF2xXIQ1QCCqcoO= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTS2M4QTBzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA4NjN5IN88UU4> MlLPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUm4OlkoRjJ2MUG5PFY6RC:jPh?=
DU145 NX;DN|VES3m2b4TvfIlkcXS7IHHzd4F6 MYnDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczygTWM2OCB;IEOuOEDPxE1w NE\oT4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG5OVQ3Pid-MkSxPVU1PjZ:L3G+
NCI-H460 NV;iWIV5S3m2b4TvfIlkcXS7IHHzd4F6 NVPlfW1FS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNuIFnDOVAhRSB6LkWg{txONg>? NF7KXJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG5OVQ3Pid-MkSxPVU1PjZ:L3G+
HCT116 NFnoXIlEgXSxdH;4bYNqfHliYYPzZZk> NVfk[GN5PzJiaILz Mn:2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA5NjN{IN88UU4> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJzMUCyNUc,OjR{MUGwNlE9N2F-
MGC803 NFu3NFhEgXSxdH;4bYNqfHliYYPzZZk> MXS3NkBpenN? NWq3SW93S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6zNkDPxE1w NV3sSm5ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVExOjFpPkK0NlEyODJzPD;hQi=>
HepG2 NXPaSlNsS3m2b4TvfIlkcXS7IHHzd4F6 NX\HN4dMPzJiaILz NFSyb5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwNEWg{txONg>? MkPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MUGwNlEoRjJ2MkGxNFIyRC:jPh?=
A549 NF3Fe2ZEgXSxdH;4bYNqfHliYYPzZZk> M1;OXFczKGi{cx?= NILqNldEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC5zMzFOwG0v NYexUFlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVExOjFpPkK0NlEyODJzPD;hQi=>
NCI-H460 NHfGO4pEgXSxdH;4bYNqfHliYYPzZZk> Mn7nO|IhcHK| NH[ydo9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuN|Ih|ryPLh?= M1nOSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkGxNFIyLz5{NEKxNVAzOTxxYU6=
SW1116 Mki4R5l1d3SxeHnjbZR6KGG|c3H5 NEH2V5c1QCCqcoO= M3XjcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYOTFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS5{NjFOwG0v MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6Nke2NUc,OjR{OE[3OlE9N2F-
HepG2 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MkfpOFghcHK| NUX4XFBkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwNEOg{txONg>? M{jh[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mki2O|YyLz5{NEK4Olc3OTxxYU6=
BGC823 NFfxSIdEgXSxdH;4bYNqfHliYYPzZZk> NIHzZ4U1QCCqcoO= MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvPDhizszNMi=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6Nke2NUc,OjR{OE[3OlE9N2F-
MCF7 M2DMd2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4TWTFQ5KGi{cx?= NYjYdZpCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS55OTFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6Nke2NUc,OjR{OE[3OlE9N2F-
MCF7 MmDIR5l1d3SxeHnjbZR6KGG|c3H5 NYLvZ|VrPDhiaILz NXm1V4c1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy53IN88UU4> NWf1U5ZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|I1QTdpPkK0N|MzPDl5PD;hQi=>
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ME180 MWfDfZRwfG:6aXPpeJkh[XO|YYm= Mo[yOFghcHK| NVe0Z5ZLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUVzOECgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwOTFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN|MkS5O{c,OjR|M{K0PVc9N2F-
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Bel7404 MVrDfZRwfG:6aXPpeJkh[XO|YYm= Mn\LOFghcHK| NY\rXZVSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSmWuN{SwOEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uPEDPxE1w M{THclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVA2Lz5{NEW2OVkxPTxxYU6=
HepG2 NV:zWlFuS3m2b4TvfIlkcXS7IHHzd4F6 NIH4WmI1QCCqcoO= NWDD[JFmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4Lkm4JO69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV4NUmwOUc,OjR3NkW5NFU9N2F-
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B16 M{i0fGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmPLO|IhcHK| NIrXZ3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFKxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuOVIh|ryPLh?= NHnkcm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyPVc1Oid-MkW1Nlk4PDJ:L3G+
Bel7402 NXvRb|lYSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1vIN|czKGi{cx?= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGxMlc5KM7:TT6= MmL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3Mkm3OFIoRjJ3NUK5O|QzRC:jPh?=
MGC803 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MkLzOFghcHK| NHXablhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwN{Gg{txONg>? MliyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NUS5NlIoRjJ3NUW0PVIzRC:jPh?=
Bcap37 MXzDfZRwfG:6aXPpeJkh[XO|YYm= MWK0PEBpenN? MnL4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoNieDN5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjF6IN88UU4> Ml;SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NUS5NlIoRjJ3NUW0PVIzRC:jPh?=
SGC7901 NWjtPZl1S3m2b4TvfIlkcXS7IHHzd4F6 NU\qOZdtPDhiaILz M3zMTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwNU[g{txONg>? NWDnNHUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OVQ6OjJpPkK1OVU1QTJ{PD;hQi=>
BALB/3T3 MoHsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlnmO|IhcHK| MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDTFKvN3Q{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJibXX0bI9lNCCLQ{WwJF0hOy5{MzFOwG0v NIOyWpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
LoVo MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoX3O|IhcHK| M1ize2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFQvPjlizszNMi=> NXLYXYFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
doxorubicin-resistant LoVo/DX NH7Me4VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{jySVczKGi{cx?= NFP1UWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHTvfI9zfWKrY3nuMZJme2m|dHHueEBNd1[xL1TYJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyIE2gOkDPxE1w NHTyeW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
SW707 M{S1Z2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4C5TFczKGi{cx?= NXy5TG1oSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|cxPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIH3leIhw\CxiSVO1NEA:KDJyLkS2JO69VS5? NHjvOnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0OFY4PCd-MkW2OFQ3PzR:L3G+
vincristine-resistant HL60/Vinc M2f3XWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWm3NkBpenN? MnnuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiC4aX7jdol{fGmwZT3y[ZNqe3SjboSgTGw3OC:YaX7jJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU4yPSEQvF2u M1G1dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
HL60 MojyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUW3NkBpenN? NXHNZWNGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOi53NDFOwG0v NWjmTIU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFQ3PzRpPkK1OlQ1Pjd2PD;hQi=>
HT-29 NH3qd3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NU\kXIt4PzJiaILz M1S1NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCvZYToc4QtKEmFNUCgQUAzPS5yODFOwG0v M3vkXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkS0Olc1Lz5{NU[0OFY4PDxxYU6=
LS180 Mn3tRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFyzdFU4OiCqcoO= MlO1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOU{G4NEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3JDKG2ndHjv[EwhUUN3MDC9JFM5Njl{IN88UU4> MnXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NES2O|QoRjJ3NkS0Olc1RC:jPh?=
B16F10 M3TnPWFvfGmlYX7j[ZIh[XO|YYm= NWrxPJM{PzJiaILz MnriRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFKxOmYyOCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNEOg{txONg>? NYPyXo9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVU4OThpPkK1OlU2PzF6PD;hQi=>
MGC803 MYTBcpRq[2GwY3XyJIF{e2G7 MmW1O|IhcHK| M2TEe2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkSzJO69VS5? M{nZUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW1O|E5Lz5{NU[1OVcyQDxxYU6=
MCF7 Mmr6RY51cWOjbnPldkBie3OjeR?= MVy3NkBpenN? M2Hsc2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5zMjFOwG0v NIPiWnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1OVcyQCd-MkW2OVU4OTh:L3G+
EC109 M2T1UGFvfGmlYX7j[ZIh[XO|YYm= Mo[3O|IhcHK| M1j2bWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFR|ExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLk[xJO69VS5? NVjwdpZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVU4OThpPkK1OlU2PzF6PD;hQi=>
HCT8 NETJRnhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXvKXIhOPzJiaILz MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEigZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOUGg{txONg>? NIK4S|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[3OVE1PCd-MkW2O|UyPDR:L3G+
HCT8 M{PsW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn3qO|IhcHK| MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IEWtSnUhemW|aYP0ZY51KGi3bXHuJGhEXDhiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM3NjZ|ODFOwG0v Mm\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{WxOFQoRjJ3Nke1NVQ1RC:jPh?=
MGC803 MVPDfZRwfG:6aXPpeJkh[XO|YYm= MXG3NkBpenN? M1Pp[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwN{Kg{txONg>? Mmf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEewNVIoRjJ3N{C3NFEzRC:jPh?=
MCF7 NEHwcmREgXSxdH;4bYNqfHliYYPzZZk> M{LLfFczKGi{cx?= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNk4zPCEQvF2u M{HDT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{C3NFEzLz5{NUewO|AyOjxxYU6=
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SMMC7721 NFm2XXZEgXSxdH;4bYNqfHliYYPzZZk> MVi3NkBpenN? NHrNUVZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCuOEDPxE1w NFHiToU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewO|AyOid-MkW3NFcxOTJ:L3G+
SW1573 NYrwUYs2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnXJOFghcHK| M{np[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2exOVc{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hPC5|IN88UU4> NVfiUoE2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVI2OjVpPkK1O|UzPTJ3PD;hQi=>
HBL100 NUG5PGNTSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml\rOFghcHK| NH\USJRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjCUFExOCClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDVwNTFOwG0v MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3MkWyOUc,OjV5NUK1NlU9N2F-
HeLa NWLEW5QySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MY[0PEBpenN? M3jQUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFE2KM7:TT6= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3MkWyOUc,OjV5NUK1NlU9N2F-
T47D MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmjrOFghcHK| M{[1RWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFQ4KM7:TT6= NYLGb41KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVI2OjVpPkK1O|UzPTJ3PD;hQi=>
WiDr Mmj4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3\uSlQ5KGi{cx?= MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFerRIKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTC0PUDPxE1w NXvTepYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVI2OjVpPkK1O|UzPTJ3PD;hQi=>
MGC803 MmWyRY51cWOjbnPldkBie3OjeR?= NIjXWHQ1QCCqcoO= M1vkTmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{42QCEQvF2u MmnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUK5OlYoRjJ3OEGyPVY3RC:jPh?=
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HepG2 MYjDfZRwfG:6aXPpeJkh[XO|YYm= M1jHOFczKGi{cx?= NIfNdVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwNEKg{txONg>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{N{e3O{c,OjZ{Mke3O|c9N2F-
A549 MV;BcpRq[2GwY3XyJIF{e2G7 M1rqOVQ5KGi{cx?= MnXORY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNVMh|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ|MUC4NEc,OjZ{M{GwPFA9N2F-
MCF7 NUDNVZdlSW62aXPhcoNmeiCjc4PhfS=> Ml;EOFghcHK| MmLaRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|Yh|ryPLh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ|MUC4NEc,OjZ{M{GwPFA9N2F-
HeLa MmjPRY51cWOjbnPldkBie3OjeR?= NVnNPHlJPDhiaILz MnzJRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuOkDPxE1w MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ|MUC4NEc,OjZ{M{GwPFA9N2F-
HaCaT MoG3R5l1d3SxeHnjbZR6KGG|c3H5 NH7Fepc1QCCqcoO= Ml\iR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHHDZXQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlI3KM7:TT6= M3q5SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkOxNFgxLz5{NkKzNVA5ODxxYU6=
Hep3B MXfDfZRwfG:6aXPpeJkh[XO|YYm= M3T5bFIh\GG7cx?= NWPOc4Y4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGOnbHyg[IVifGhiaX7jeYJifGWmIH\vdkAzKGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS53IN88UU4> M4\3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkW5PFAzLz5{NkK1PVgxOjxxYU6=
Bcap37 MVzDfZRwfG:6aXPpeJkh[XO|YYm= Mo[wNkBl[Xm| NYrVflNJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSmOjcEO3JINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iClZXzsJIRm[XSqIHnuZ5Vj[XSnZDDmc5IhOiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNUig{txONg>? NIDrXZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PVgxOid-Mk[yOVk5ODJ:L3G+
MCF7 MnrXR5l1d3SxeHnjbZR6KGG|c3H5 NH;ZXGUzKGSjeYO= M1rJOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJINmdGxiZHXheIghcW6ldXLheIVlKG[xcjCyJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVEvPSEQvF2u NFrjNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PVgxOid-Mk[yOVk5ODJ:L3G+
HepG2 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NYjYVnJtOiCmYYnz NVTMNZJSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGOnbHyg[IVifGhiaX7jeYJifGWmIH\vdkAzKGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwM{Sg{txONg>? MnHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NUm4NFIoRjJ4MkW5PFAzRC:jPh?=
A549 M1;CXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MV6yJIRigXN? NGXkfJFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ1NjB3IN88UU4> NXnlXGpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVk5ODJpPkK2NlU6QDB{PD;hQi=>
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MIAPaCa2 NFjHe4tCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXXIT5l4PzJiaILz NVO2NHlJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNTWFR[UOjMjDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS54NzFOwG0v NVLFPZgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
MCF7 NXXZ[ZV3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1v5O|Q5KGi{cx?= M4X5TWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6wNVIh|ryPLh?= M13DRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{CxOVU5Lz5{NkOwNVU2QDxxYU6=
DU145 NHfmNGxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFTwO|U1QCCqcoO= NG\1cnZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC2MlA4OiEQvF2u NFTFSWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOwNVU2QCd-Mk[zNFE2PTh:L3G+
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MCF7 NIHHS4tEgXSxdH;4bYNqfHliYYPzZZk> MXe0PEBpenN? MkPDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVkvOzlizszNMi=> M3f2SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{[zPFY6Lz5{NkO2N|g3QTxxYU6=
A549 NHfnfVVEgXSxdH;4bYNqfHliYYPzZZk> NUnOdo9nPDhiaILz MlHXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlIvOjhizszNMi=> Mo\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NkO4OlkoRjJ4M{[zPFY6RC:jPh?=
PC3 M1jNVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NH7xTWI1QCCqcoO= M1\GVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlIvPjNizszNMi=> NGjwPYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO2N|g3QSd-Mk[zOlM5Pjl:L3G+
HepG2 NITkNZpEgXSxdH;4bYNqfHliYYPzZZk> Mm\JOFghcHK| MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NUH1ZZdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zOlM5PjlpPkK2N|Y{QDZ7PD;hQi=>
HT-29 M2DRSmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DjfVQ5KGi{cx?= NH[w[pdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliV2PUMVEh[XO|YYmsJGlEPTBiPTCxOU45OyEQvF2u NXjpfpZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NVM4OjVpPkK2OFE{PzJ3PD;hQi=>
PA1 MULBcpRq[2GwY3XyJIF{e2G7 NXfpdnNbPDhiaILz NHXBTphCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGEyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlU6KM7:TT6= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRzM{eyOkc,OjZ2MUO3NlY9N2F-
BT549 M37PV2FvfGmlYX7j[ZIh[XO|YYm= MofmOFghcHK| NGnZTpNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE6Njh{IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRzM{eyOkc,OjZ2MUO3NlY9N2F-
DU145 MUXBcpRq[2GwY3XyJIF{e2G7 MU[0PEBpenN? MYrBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO5MlE4KM7:TT6= MkfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MUO3NlYoRjJ4NEGzO|I3RC:jPh?=
MDA-MB-231 NInUcnFCdnSrY3HuZ4VzKGG|c3H5 NXLPXZV7PDhiaILz MXrBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDVwNEOg{txONg>? NHToS|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSxN|czPid-Mk[0NVM4OjZ:L3G+
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MCF7 MWfDfZRwfG:6aXPpeJkh[XO|YYm= Moj3OFghcHK| MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyJO69VS5? M4jsfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEW0N|c2Lz5{Nki1OFM4PTxxYU6=
HCT116 MofyR5l1d3SxeHnjbZR6KGG|c3H5 Ml3tOFghcHK| NVLpVnVPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkOg{txONg>? NEjE[5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1OFM4PSd-Mk[4OVQ{PzV:L3G+
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Hep3B MmDnR5l1d3SxeHnjbZR6KGG|c3H5 NUDa[Ys{PDhiaILz M1;LTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC53MzFOwG0v NYXmPY9yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4PFMyPDhpPkK2PFg{OTR6PD;hQi=>
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Bcap37 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NWTwXHkzPDhiaILz NFnxUoZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD[2GyM{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR5LkC5JO69VS5? NELXOFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki4N|E1QCd-Mk[4PFMyPDh:L3G+
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HCT116 M1jDRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmDmO|IhcHK| NV\vbGZ[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM5NjNizszNMi=> NI\0co89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlIzOyd-Mk[5NlIzOjN:L3G+
HepG2 M1yz[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlvJO|IhcHK| MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2OT6wNkDPxE1w MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKyN{c,OjZ7MkKyNlM9N2F-
HT-29 NV:3XVhGSW62aXPhcoNmeiCjc4PhfS=> MXq3NkBpenN? MXnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk4{KM7:TT6= M4nD[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKyNlM{Lz5{NkmyNlI{OzxxYU6=
RKO M3XSTGFvfGmlYX7j[ZIh[XO|YYm= NX;Jdm1GPzJiaILz NWL2TI1SSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHJMVyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA3NjhizszNMi=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKzN{c,OjZ7MkKyN|M9N2F-
HT-29 M{Xj[WFvfGmlYX7j[ZIh[XO|YYm= MmPvOFghcHK| MWnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUh|ryPLh?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKzN{c,OjZ7MkKyN|M9N2F-
HCT116 Ml\BRY51cWOjbnPldkBie3OjeR?= MY[3NkBpenN? MnfORY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPy56IN88UU4> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKzN{c,OjZ7MkKyN|M9N2F-
RKO NWHOfo85SW62aXPhcoNmeiCjc4PhfS=> NW\ZWoF1PDhiaILz NIPJTFBCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVmtQKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIgh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQyNjFizszNMi=> NH21RZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyNlI{Oyd-Mk[5NlIzOzN:L3G+
KB NIXN[m1EgXSxdH;4bYNqfHliYYPzZZk> M2nWdFczKGi{cx?= NHriRoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE45PCEQvF2u NITjZm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2PSd-MkewO|MxPTV:L3G+
HeLa M2TKc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmW2O|IhcHK| NFixVmlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA3NjJ|IN88UU4> M4\RZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
MCF7 MljpR5l1d3SxeHnjbZR6KGG|c3H5 NHXZN4M4OiCqcoO= NFfvfYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5Y3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFYvPTNizszNMi=> MoDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
HepG2 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NV7GOXl3PzJiaILz M3noVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA3NjZizszNMi=> NUPpbHR4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|MxPTVpPkK3NFc{ODV3PD;hQi=>
HDF M2HCTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIDkZ|E4OiCqcoO= MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBJTEZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFcvODJizszNMi=> MnjHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{OwOVUoRjJ5MEezNFU2RC:jPh?=
143B NHmxUWpEgXSxdH;4bYNqfHliYYPzZZk> NEXvT3c4OiCqcoO= MlPXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVQ{SiClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVMvODFizszNMi=> M1XVZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
thymidine kinase deficient 143B NH[1cZhEgXSxdH;4bYNqfHliYYPzZZk> NEPLelI4OiCqcoO= NWfjdWk5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhOTR|QjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOTZwM{Gg{txONg>? M1PsblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEezNFU2Lz5{N{C3N|A2PTxxYU6=
U87MG NF7xXo1EgXSxdH;4bYNqfHliYYPzZZk> MUO3NkBpenN? NWHm[JJpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTh5TVegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDaNkBkd3WudHXyJINwfW62ZYKgcYV1cG:mLDDJR|UxKD1iMUiuNlUh|ryPLh?= NGjvO5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C4NVc1Oid-MkewPFE4PDJ:L3G+
PC3 MoDoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1u4NVQ5KGi{cx?= NH\4SpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj63OkDPxE1w NVzLeGZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
HT-29 M2PtdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1fx[|Q5KGi{cx?= MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Lkig{txONg>? M1;vV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEmyOFE{Lz5{N{C5NlQyOzxxYU6=
U87MG M1W2SGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MX20PEBpenN? Mli4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz62OUDPxE1w MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB7MkSxN{c,OjdyOUK0NVM9N2F-
A549 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NEDvT5k1QCCqcoO= NX61d|FtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlk5KM7:TT6= NWL4NZpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
HaCaT MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHrtbGQ1QCCqcoO= MnjIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKYVPhWEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uNVUh|ryPLh?= NUHJO4lkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewPVI1OTNpPkK3NFkzPDF|PD;hQi=>
MGC803 MlrFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mm\SO|IhcHK| MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkK1JO69VS5? NEfncHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
EC109 MnrTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVK3NkBpenN? MoLWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHQ{GwPUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|LkG3JO69VS5? NFH2[JI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwOVAzQCd-MkexNFUxOjh:L3G+
SH-SY5Y M17rNmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHy4d5Y4OiCqcoO= NFmybGFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPIMXN[PVliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4zPiEQvF2u MnvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEWwNlgoRjJ5MUC1NFI5RC:jPh?=
U87 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1T1UVczKGi{cx?= MnzDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MTFOwG0v NYnpUWhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNFUxOjhpPkK3NVA2ODJ6PD;hQi=>
MCF7 NVT4e3pVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MW[3NkBpenN? M4nqRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5Lk[xJO69VS5? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyNUCyPEc,OjdzMEWwNlg9N2F-
MDA-MB-231 M2HVZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF;UTZY1QCCqcoO= NEnkPVVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2Lk[g{txONg>? NYnlZ25oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyQDBpPkK3NVI5OThyPD;hQi=>
MCF7 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4jLVVQ5KGi{cx?= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyLkSxJO69VS5? NF62[Hg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE5OCd-MkexNlgyQDB:L3G+
A549 MVjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXW5eW9OPDhiaILz M3LBZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuOFEh|ryPLh?= M2DyUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
HepG2 M172O2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NG[5PXc1QCCqcoO= NEPRWIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Ok45OyEQvF2u M4LSOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVgxLz5{N{GyPFE5ODxxYU6=
MCF7 MlewR5l1d3SxeHnjbZR6KGG|c3H5 MWW0PEBpenN? NHT2Z|FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOy53IN88UU4> M1qxR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOzOVk{Lz5{N{GzN|U6OzxxYU6=
Bcap37 NELCUnJEgXSxdH;4bYNqfHliYYPzZZk> MUi0PEBpenN? NGn3R3VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD[2GyM{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkS3JO69VS5? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
Hep3B MkD6R5l1d3SxeHnjbZR6KGG|c3H5 MmTiOFghcHK| NFvzem5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTdwNUOg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
A549 Mnr0R5l1d3SxeHnjbZR6KGG|c3H5 M4W1blQ5KGi{cx?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU42QCEQvF2u NU\URnhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexN|M2QTNpPkK3NVM{PTl|PD;hQi=>
U251 MnK2R5l1d3SxeHnjbZR6KGG|c3H5 MmPkOFghcHK| M3fDT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzPTFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI1NjZ7IN88UU4> MmnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{O1PVMoRjJ5MUOzOVk{RC:jPh?=
HepG2 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NHvLdoc1QCCqcoO= M1rMcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPS5zNzFOwG0v MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|M{W5N{c,OjdzM{O1PVM9N2F-
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Bcap37 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NV;iNJRZPDhiaILz MnzCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRoNieDN5IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3LkG4JO69VS5? MlvKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEm2O|YoRjJ5MUi5Olc3RC:jPh?=
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MCF7 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NEm2Z2EzPCCqcoO= M2HGS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bj[XOnZDDtbYNzd3Olb4DpZ{BidmGueYPpd{whUUN3MDC9JFEyNjFizszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ|NEi5N{c,Ojd{M{S4PVM9N2F-
HepG2 NXrs[FV5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGq3V3I1QCCqcoO= NUnYS3JOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NXTDWHdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFc{PjhpPkK3Nlg4OzZ6PD;hQi=>
A375-S2 NVXTVXI{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXe0PEBpenN? NVX5WXUxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBN|c2NVN{IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBz\WS3Y4Tpc44h[XO|YYmsJGlEPTBiPTCxMlkyKM7:TT6= NUTP[mtJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPVU2ODZpPkK3Nlk2PTB4PD;hQi=>
ACHN Mk\hRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3rlcFQ5KGi{cx?= MmnVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDQ1jOJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUAzNjd|IN88UU4> MoPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd{OUW1NFYoRjJ5Mkm1OVA3RC:jPh?=
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MDA-MB-231 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Moq1O|IhcHK| NXP2fXFtSW62aYDyc4xq\mW{YYTpc44h[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgW3NVNThiYYPzZZktKEmFNUCgQUA2NjJizszNMi=> NWXp[GNzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezNVE5QTVpPkK3N|EyQDl3PD;hQi=>
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WI38 MlS0R5l1d3SxeHnjbZR6KGG|c3H5 MUC0PEBpenN? NH\icYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUTN6IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNDFOwG0v MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzN2M{i1N{c,Ojd|NEO4OVM9N2F-
HepG2 NHn0V|REgXSxdH;4bYNqfHliYYPzZZk> NXrFXXdbPDhiaILz NF33cIlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEig{txONg>? MlHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd|NEO4OVMoRjJ5M{SzPFU{RC:jPh?=
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MDA-MB-231 NXvRfngyS3m2b4TvfIlkcXS7IHHzd4F6 MVm0PEBpenN? MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN3LkmxJO69VS5? MnLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi3O|QoRjJ5NES4O|c1RC:jPh?=
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prostate cancer cell MmPFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NILCcpQ1QCCqcoO= MonlS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAzOi55IN88UU4> NVe1RndpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OVQ1PDRpPkK3OVU1PDR2PD;hQi=>
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DU145 Ml;rR5l1d3SxeHnjbZR6KGG|c3H5 NWrCd4hlPDhiaILz MkXBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nj6xJO69VS5? NYjCN2o{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
HeLa MV;DfZRwfG:6aXPpeJkh[XO|YYm= MY[0PEBpenN? NU\EZ4hOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK4MlIh|ryPLh?= NXPON3lNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OThpPkK3OVYyPzF6PD;hQi=>
IOSE-144 NVLMdnRyS3m2b4TvfIlkcXS7IHHzd4F6 M3G3eFQ5KGi{cx?= MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDJU3NGNTF2NDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2MlEh|ryPLh?= M4nvbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E5Lz5{N{W2NVcyQDxxYU6=
HepG2 MonFR5l1d3SxeHnjbZR6KGG|c3H5 NEPWXFNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGK7IF3UWEBie3OjeTygTWM2OCB;IEGuN{DPxE1w NWew[HU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OTlpPkK3OVYyPzF7PD;hQi=>
DU145 NFnTeGNEgXSxdH;4bYNqfHliYYPzZZk> M3HaT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMT62JO69VS5? M3H0dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[xO|E6Lz5{N{W2NVcyQTxxYU6=
MDA-MB-231 MoX5R5l1d3SxeHnjbZR6KGG|c3H5 NWizeFlNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NXqxOIs5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OlE4OTlpPkK3OVYyPzF7PD;hQi=>
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MGC803 Mo\OR5l1d3SxeHnjbZR6KGG|c3H5 MXi3NkBpenN? MmPCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iMUCuOlQh|ryPLh?= MlXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3OUe0NVEoRjJ5NUm3OFEyRC:jPh?=
HL-7702 NV\uVYdTS3m2b4TvfIlkcXS7IHHzd4F6 M{ezUlczKGi{cx?= NETTenBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVC15N{CyJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gNVIvQDVizszNMi=> NWrhendJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1PVc1OTFpPkK3OVk4PDFzPD;hQi=>
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MDA-MB-231 NGrtVnREgXSxdH;4bYNqfHliYYPzZZk> NHyxXFY1QCCqcoO= M2LlOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuPVgh|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZzNESwPEc,Ojd4MUS0NFg9N2F-
DU145 NU\MOph{S3m2b4TvfIlkcXS7IHHzd4F6 MYW0PEBpenN? NGHuVpFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OC53ODFOwG0v NXzvfllIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVQ1ODhpPkK3OlE1PDB6PD;hQi=>
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HeLa MoK5R5l1d3SxeHnjbZR6KGG|c3H5 MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS54IN88UU4> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd{MEK5Okc,Ojd5MkCyPVY9N2F-
PC3 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NHP4[4hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkig{txONg>? NFrRc4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{eyNFI6Pid-Mke3NlAzQTZ:L3G+
HepG2 NGDmd5lEgXSxdH;4bYNqfHliYYPzZZk> MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwODFOwG0v NVT3fJc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NlAzQTZpPkK3O|IxOjl4PD;hQi=>
MDA-MB-231 MYTDfZRwfG:6aXPpeJkh[XO|YYm= Ml;WR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvQSEQvF2u MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd{MEK5Okc,Ojd5MkCyPVY9N2F-
L1210 NFXTNGJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIW0VIE1QCCqcoO= Mmm0RY51cS2ycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEmFNUCgQUAxNjN|IN88UU4> M3Xq[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
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CEM Ml;vRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEe4XHQ4OiCqcoO= M3vqdGFvfGlvcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPFUUBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFE5KM7:TT6= NH\3RpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
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MGC803 M1L0bGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVnM[Wl6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkG0JO69VS5? NGHFfFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVA{PCd-Mke3OlkxOzR:L3G+
A549 MlzjR5l1d3SxeHnjbZR6KGG|c3H5 M{OxSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvQTVizszNMi=> MlG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|QoRjJ5N{[5NFM1RC:jPh?=
EC109 NWTSdXc6S3m2b4TvfIlkcXS7IHHzd4F6 NE\YemhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGSzFyOTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDifUBOXFRiYYPzZZktKEmFNUCgQUAzPS57OTFOwG0v NYXSTno{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OlkxOzRpPkK3O|Y6ODN2PD;hQi=>
MGC803 NYG2VXVWSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NV;CSHdDPzJiaILz NFfPT4JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4{PSEQvF2u MlzaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{G1PVkoRjJ5N{exOVk6RC:jPh?=
MCF7 M{HEfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnzWO|IhcHK| MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMkWg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5MUW5PUc,Ojd5N{G1PVk9N2F-
EC109 M1HwXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoTOO|IhcHK| MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFMUC5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61PUDPxE1w NH:xfWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3NVU6QSd-Mke3O|E2QTl:L3G+
HUCCA MoDnR5l1d3SxeHnjbZR6KGG|c3H5 MUOyOEBpenN? M{TJbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiXQ1PBJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{41KM7:TT6= NX;yOIw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4NlU4PjNpPkK3PFI2PzZ|PD;hQi=>
QBC939 M3f3VGN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml[3NlQhcHK| MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRRmM6OzliY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkGg{txONg>? NUPHd2dERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4NlU4PjNpPkK3PFI2PzZ|PD;hQi=>
SW620 NWPFdVBUSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mm\BO|IhcHK| NV61eZdsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xQCEQvF2u NWXZeWRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
CFPAC-1 MmXHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVm3NkBpenN? MojERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFRmDBR{0yKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE1KM7:TT6= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh5NUe3PUc,Ojd6N{W3O|k9N2F-
WI38 MmjxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIXwdmQ4OiCqcoO= MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLM{igZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOUSg{txONg>? NGXRVoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
A549 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{\pWFczKGi{cx?= NXLSdJRJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlgh|ryPLh?= NVL2RWFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4O|U4PzlpPkK3PFc2Pzd7PD;hQi=>
HeLa MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWjZcpNZPzJiaILz MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDhwOEGg{txONg>? MmrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6N{W3O|koRjJ5OEe1O|c6RC:jPh?=
HepG2 M4G2cGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWXQdIxmPzJiaILz M4nRbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuPUDPxE1w NEjYclc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i3OVc4QSd-Mke4O|U4Pzl:L3G+
Hep3B MkXhR5l1d3SxeHnjbZR6KGG|c3H5 NXTMSGZTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlM3KM7:TT6= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzM{G3PUc,Ojd7MUOxO|k9N2F-
A549 M1zKPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFjFOIZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uOlMh|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzM{G3PUc,Ojd7MUOxO|k9N2F-
WISH MnTCR5l1d3SxeHnjbZR6KGG|c3H5 M3ziTlI1KGi{cx?= M3TZUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdKW0hiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkGg{txONg>? NEHRbng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1NVQ5Pyd-Mke5OVE1QDd:L3G+
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A549 NF\tcXhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWL5UXY6PzJiaILz MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwMU[g{txONg>? NYfvfHM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFc1QDVpPkK3PVg4PDh3PD;hQi=>
MDA-MB-231 M{TIN2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVG3NkBpenN? NVf0d3hISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3IN88UU4> Mn6wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEe0PFUoRjJ5OUi3OFg2RC:jPh?=
HepG2 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXm3NkBpenN? MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3IN88UU4> M3\6U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUi3OFg2Lz5{N{m4O|Q5PTxxYU6=
MCF7 NIrjbnJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUfO[HFHPzJiaILz NUL0dmZrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlEzKM7:TT6= M2Xk[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUi3OFg2Lz5{N{m4O|Q5PTxxYU6=
Hep3B NIfJ[3dEgXSxdH;4bYNqfHliYYPzZZk> NYnjPHYyPDhiaILz MVHDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYCzRkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPTNizszNMi=> MojiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUO1NVYoRjJ5OUmzOVE3RC:jPh?=
HepG2 M1z4bGN6fG:2b4jpZ4l1gSCjc4PhfS=> MniyOFghcHK| NY\vZWJSS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN{Lk[g{txONg>? NXnBfI1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PVM2OTZpPkK3PVk{PTF4PD;hQi=>
HepG2 MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYGyOEBpenN? NGLJbm5Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzJwOEeg{txONg>? NXXtW2NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNVEzOjBpPkK4NFEyOjJyPD;hQi=>
PA1 NFHJ[WJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnXqNlQhcHK| M4PwSGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBCOSClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|kvPSEQvF2u NIrqTZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOCd-MkiwNVEzOjB:L3G+
HCT15 NFf4W3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXKyOEBpenN? MnqyS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ2NjBzIN88UU4> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDBzMUKyNEc,OjhyMUGyNlA9N2F-
PC3 NFf2do5EgXSxdH;4bYNqfHliYYPzZZk> M{fFUlczKGi{cx?= Mm[xR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVUvOzFizszNMi=> NGTxbIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOyd-MkiwNVEzOjN:L3G+
SKOV3 NHSzVVNEgXSxdH;4bYNqfHliYYPzZZk> NES0[HM4OiCqcoO= NELBXplEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDJ|LkGxJO69VS5? NGLBdm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOyd-MkiwNVEzOjN:L3G+
A549 NXL2eGI3S3m2b4TvfIlkcXS7IHHzd4F6 MkjOO|IhcHK| MWPDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gN|IvOTVizszNMi=> Mn3KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyMUGyNlMoRjJ6MEGxNlI{RC:jPh?=
HepG2 MkDBR5l1d3SxeHnjbZR6KGG|c3H5 M{PJdVQ5KGi{cx?= MoW0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[2:ub4LpcYV1emmlIHHzd4F6NCCLQ{WwJF0hOTBwMUeg{txONg>? Mn31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlcoRjJ6MEO4N|I4RC:jPh?=
Hep3B M1;pNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2G5bFQ5KGi{cx?= M1jhdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDFyLkWzJO69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyO{c,OjhyM{izNlc9N2F-
A549 NFPRbIFEgXSxdH;4bYNqfHliYYPzZZk> Mn3DOFghcHK| NWHEZYVUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCClb3zvdolu\XS{aXOgZZN{[XluIFnDOVAhRSB|ND6yO{DPxE1w NVvmNlhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjdpPkK4NFM5OzJ5PD;hQi=>
MCF7 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NHvSemo1QCCqcoO= MoLPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBkd2yxcnnt[ZRzcWNiYYPzZZktKEmFNUCgQUA1Oi55ODFOwG0v NXX3[pBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjdpPkK4NFM5OzJ5PD;hQi=>
Bcap37 MorZR5l1d3SxeHnjbZR6KGG|c3H5 M4HvelQ5KGi{cx?= M4P2VGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJk[XB|NzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCClb3zvdolu\XS{aXOgZZN{[XluIFnDOVAhRSB2Nz6xJO69VS5? M1vvO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N|I4Lz5{OECzPFMzPzxxYU6=
U251 NE\0OFZEgXSxdH;4bYNqfHliYYPzZZk> NXTQU5c6PDhiaILz NE\5cJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NEA:KDR6Lk[4JO69VS5? NXjjXFdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjdpPkK4NFM5OzJ5PD;hQi=>
MGC803 NH7kflBEgXSxdH;4bYNqfHliYYPzZZk> NH3ENZQ1QCCqcoO= Ml\HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNlEh|ryPLh?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyPUc,OjhyM{izNlk9N2F-
EC109 MoXUR5l1d3SxeHnjbZR6KGG|c3H5 NGjKb2Y1QCCqcoO= MkTsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSWMyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuN{DPxE1w MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyPUc,OjhyM{izNlk9N2F-
PC3 M2HBUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjWXZdjPDhiaILz MoW0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ7LkOxJO69VS5? NV3lU|Y4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjlpPkK4NFM5OzJ7PD;hQi=>
A549 NEjjbVZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnjHOFghcHK| NEm5clBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlUh|ryPLh?= NWqwRmFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwO|M3PzZpPkK4NFc{Pjd4PD;hQi=>
MCF7 M1\hTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXzzdZAyPDhiaILz M1HHRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUmuNkDPxE1w MnLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyN{O2O|YoRjJ6MEezOlc3RC:jPh?=
HCT116 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn\MOFghcHK| NEfh[GFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlkvOiEQvF2u MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB5M{[3Okc,OjhyN{O2O|Y9N2F-
BGC823 NVfYeIxvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGP2So41QCCqcoO= NYPafZBmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM1NjhizszNMi=> MlPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyN{O2O|YoRjJ6MEezOlc3RC:jPh?=
IOSE-144 M3jldWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3rzbFQ5KGi{cx?= NHThWHJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnPV2UuOTR2IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{QC5zIN88UU4> MlrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyN{O2O|YoRjJ6MEezOlc3RC:jPh?=
MCF7 NGnHPYFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGXhRVg1QCCqcoO= MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4LkG0JO69VS5? M2XBR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUGwPFcyLz5{OEGxNFg4OTxxYU6=
HCT116 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVu0PEBpenN? MmrqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO4MlMh|ryPLh?= NWHhWG13RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVA5PzFpPkK4NVExQDdzPD;hQi=>
PANC1 MmriRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MojpOFghcHK| NETzVlBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0O{45OyEQvF2u M4r4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUGwPFcyLz5{OEGxNFg4OTxxYU6=
HepG2 NFvTbnpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXHjfFBsPDhiaILz NWrWd2xHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFkvODJizszNMi=> NUD0SppbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVA5PzFpPkK4NVExQDdzPD;hQi=>
BCG823 NFm0UVBEgXSxdH;4bYNqfHliYYPzZZk> M37idVQ5KGi{cx?= NFLSd4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS0d6MkOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4yKM7:TT6= M3PF[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUG3NlAzLz5{OEGxO|IxOjxxYU6=
A549 MV\DfZRwfG:6aXPpeJkh[XO|YYm= MonjOFghcHK| MkHoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkGg{txONg>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzN{KwNkc,OjhzMUeyNFI9N2F-
HepG2 MlfmR5l1d3SxeHnjbZR6KGG|c3H5 MY[0PEBpenN? M3jmZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuNkDPxE1w NGjOcmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxO|IxOid-MkixNVczODJ:L3G+
EC9706 MlnSRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MorBOFghcHK| M4DBUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRVO5O|A3KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyN{4zPiEQvF2u MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFzOUKwNEc,OjhzMUmyNFA9N2F-
ECA109 NHjNVXdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnTSOFghcHK| M4S4fmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRVPBNVA6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNE4zPSEQvF2u NXPHOnlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVkzODBpPkK4NVE6OjByPD;hQi=>
K562 NGL4XWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPiU3dQPDhiaILz NVzZZpFWT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhX1OWMTDhd5NigSxiSVO1NEA:KDN6LkW4JO69VS5? MoT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMk[0N|YoRjJ6MUK2OFM3RC:jPh?=
KKU-M214 NYLHS5VkS3m2b4TvfIlkcXS7IHHzd4F6 M4O0TFczKGi{cx?= MljIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2tWNU1{MUSgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlc3KM7:TT6= NGH0Zlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG0NFU6Oid-MkixOFA2QTJ:L3G+
HL60 NXzwXWV5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHPVV3U1QCCqcoO= MnjtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSBzLk[yJO69VS5? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3MkSzNEc,OjhzNUK0N|A9N2F-
NCI-H1299 MkP4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGL4Tmw1QCCqcoO= NGOxeZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTJ7OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hQC57MTFOwG0v NVLKcWFRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVI1OzBpPkK4NVUzPDNyPD;hQi=>
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Hep3B MoXoR5l1d3SxeHnjbZR6KGG|c3H5 NEHJ[YI1QCCqcoO= NHHueGlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB|QjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEmuO|Ih|ryPLh?= M1\aNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUe0NVA4Lz5{OEG3OFExPzxxYU6=
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Bel7402 M4rGOWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MY[3NkBpenN? MnHvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFUvQTRizszNMi=> M2fIXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{CxPFE2Lz5{OEOwNVgyPTxxYU6=
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HCT116 NFXlZpFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWrQ[ZFkPzJiaILz NHjaPWJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE4yPiEQvF2u M2DzeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEW4NVM{Lz5{OES1PFE{OzxxYU6=
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MCF7 NFuxc3VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXW0PEBpenN? NW[zcWlKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNk43OjZizszNMi=> NFXEUVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|cyPyd-MkmyNlM4OTd:L3G+
HCT116 NUXZbVM3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MW[3NkBpenN? NXTP[XpQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI6NjVizszNMi=> M{fBSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MkOyOVg{Lz5{OUKzNlU5OzxxYU6=
SGC7901 M2TvdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoOyO|IhcHK| MlTpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVR1O3PVAyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzOE41KM7:TT6= NWjJN|d6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyN|I2QDNpPkK5NlMzPTh|PD;hQi=>
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HCT116 MnTZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2P0bFczKGi{cx?= MnixRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGxMlI6KM7:TT6= NF:ydow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOxOlU{Pid-MkmzNVY2OzZ:L3G+
MGC803 NUP5WFZ{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnrDO|IhcHK| MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkWuOVQh|ryPLh?= MlnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|MU[1N|YoRjJ7M{G2OVM3RC:jPh?=
MGC803 NX;3RWk2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NW\zPJpXPzJiaILz MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz64OkDPxE1w Mn;WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5OFYoRjJ7NEC3PVQ3RC:jPh?=
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PC3 MlTQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2HNbVczKGi{cx?= NHS4[JJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkeuOlEh|ryPLh?= M4P5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVQ3Lz5{OUSwO|k1PjxxYU6=
HL60 M1;pb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYTkfIZbPzJiaILz NIDmdlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|ch|ryPLh?= MnrrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5PFMoRjJ7NEC3PVg{RC:jPh?=
Bel7402 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUW3NkBpenN? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG4MlQ6KM7:TT6= M3\B[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVg{Lz5{OUSwO|k5OzxxYU6=
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EC9706 MVPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGKxcmk4OiCqcoO= MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWFOUewOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT6xN{DPxE1w MmT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2N{WxOVYoRjJ7NEe1NVU3RC:jPh?=
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MGC803 MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnXMO|IhcHK| MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6yOEDPxE1w MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR5NUG1Okc,Ojl2N{WxOVY9N2F-
SMMC7721 NUDtdXRXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M176bVczKGi{cx?= MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOPTVO3O|IyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{44KM7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR5NUG1Okc,Ojl2N{WxOVY9N2F-
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QSG7701 NYP0[ZBTSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3rwUlI1KGi{cx?= MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFGVR{e3NFEh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gOk46OiEQvF2u MmPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OUm0PVAoRjJ7NEm5OFkxRC:jPh?=
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LoVo Mn;KS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3u1PFQ5KGi{cx?= M2TYcmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGxwXm9iY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTFwNTFOwG0v NE\ObGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGwOlI5QSd-M{CxNFYzQDl:L3G+
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MGC803 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWq3NkBpenN? NHLwfWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|EvODRizszNMi=> NXHIdoFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOFI3OTJpPkOwNVQzPjF{PD;hQi=>
HCT116 NWnZ[5ZnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnHOO|IhcHK| MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{iuN{DPxE1w MnvMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEK2NVIoRjNyMUSyOlEzRC:jPh?=
HepG2 M1HJNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{HOe|czKGi{cx?= M13YUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES3Mlk4KM7:TT6= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF2Mk[xNkc,OzBzNEK2NVI9N2F-
A549 M3G1XmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NX3QfXEyPzJiaILz NIe1cY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNFUh|ryPLh?= NHz3V4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0N|E2Oyd-M{CyOFMyPTN:L3G+
Bel7402 NEiwNVlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWX5WJVsPzJiaILz NEPQOldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE5NjZ3IN88UU4> Mlj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEOxOVMoRjNyMkSzNVU{RC:jPh?=
MCF7 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Ml3RO|IhcHK| MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5Lki5JO69VS5? MnvkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEOxOVMoRjNyMkSzNVU{RC:jPh?=
T84 NELtTHFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{e5fFMh\GG7cx?= NF3B[2ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS4OEBk\WyuczDh[pRmeiB|IHThfZMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFMvPCEQvF2u Mmj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEi2OVcoRjNyMkS4OlU4RC:jPh?=
A549 NG[zOpJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXKzJIRigXN? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTC3MlEh|ryPLh?= NX\ROIs{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyOFg3PTdpPkOwNlQ5PjV5PD;hQi=>
MCF7 NXfrV4lJSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWCzJIRigXN? NX;PVndUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwJF0hPy56IN88UU4> MmnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEi2OVcoRjNyMkS4OlU4RC:jPh?=
A549 NWThT5NXS3m2b4TvfIlkcXS7IHHzd4F6 Moj0O|IhcHK| NEXyZ4FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1NjNizszNMi=> Mn7xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|MUi0OFAoRjNyM{G4OFQxRC:jPh?=
HeLa NUfIVZVoS3m2b4TvfIlkcXS7IHHzd4F6 M{LJSFczKGi{cx?= NVnj[HV4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwN{Wg{txONg>? NE\Mb4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEOxPFQ1OCd-M{CzNVg1PDB:L3G+
HCT116 MkDzR5l1d3SxeHnjbZR6KGG|c3H5 MlO5O|IhcHK| M2DxPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwNU[g{txONg>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODNzOES0NEc,OzB|MUi0OFA9N2F-
NCI-H460 M2jxemN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn3NO|IhcHK| MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwN{Wg{txONg>? NYTSeGVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVg1PDBpPkOwN|E5PDRyPD;hQi=>
HCT15 M33NTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M37hUFczKGi{cx?= MoXLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEyNjh5IN88UU4> NVr1O2oyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVg1PDBpPkOwN|E5PDRyPD;hQi=>
MDA-MB-231 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NH\tUVk4OiCqcoO= M{Ptc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKxMlA2KM7:TT6= MoraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|MUi0OFAoRjNyM{G4OFQxRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / PUMA / c-PARP; 

PubMed: 25965911     


(A) HCT-116 cells were treated with various doses of 5-FU for 24 hours (B) HCT-116 cells were treated with 200 uM 5-FU, then harvested at different time points after stimulation. The expression of p53, PUMA, cleaved PARP and P-Akt(S473) were detected by western blotting in different conditions.

25965911
Immunofluorescence
caveolin-3; 

PubMed: 23646193     


Cells were stained with an antibody against caveolin-3 (green) and with DAPI (blue). (A) control cells (top images), 10 mM 5-FU (middle images), 50 mM 5-FU (bottom images). Merged images are shown at the right of each panel.

phospho-histone H3 ; 

PubMed: 23646193     


Cells were grown for 24 h, treated with 5-FU and stained with an anti-phospho-histone H3 antibody (red) and with DAPI (blue). (A) control cells, (B) 0.1 mM 5-FU and (C) 1 mM 5-FU. 

p65 / p-p65(Ser536) / p53 / p-p53(Ser15); 

PubMed: 24587255     


E–H, Immunocytochemistry of p65 and p53 induction and localization by 5-FU treatment for the indicated cell lines. p65 (red), phosphor-p65 (Ser536; red), p53 (green), phospho-p53 (Ser15; red), and DAPI (blue) staining of the nucleus without (control) and with 5-FU treatment. 

Sox2 / Oct4 / Nanog / ABCG2; 

PubMed: 27009861     


(A) Immunofluorescence staining of Sox2, Oct4 and Nanog in HBE cells with or without 5-FU treatment. In untreated HBE cells, few Sox2, Oct4 or Nanog-positive cells were observed. After 5-FU treatment, the number of Sox2, Oct4 or Nanog-positive cells increased remarkably. Nuclei were counterstained with DAPI (blue). (B) Immunofluorescence staining of ABCG2 in HBE cells with or without 5-FU treatment. 

β-catenin; 

PubMed: 30111797     


Immunofluorescence detection of β-catenin in HCT-8 cells. Scale bar, 20 μm.

non-phospho β-catenin; 

PubMed: 28588704     


Effect of enhanced WNT signaling in Ell3 OE cells. Localization of non-phosphorylated β-catenin was analyzed by immunocytochemical staining in (A) control MCF-7 and (B) Ell3 OE treated with various 5-FU concentrations.

23646193 24587255 27009861 30111797 28588704
Growth inhibition assay
Cell viability; 

PubMed: 25965911     


Cells viability was analyzed using Cell Counting Kit-8 at 0, 3, 6, 12 and 24 hours after (A) 50, 100, 200, or 400 uM 5-FU treatment in HCT116 cells.

Cell proliferation; 

PubMed: 30250641     


(A) Cell proliferation assay with resveratrol in HCT116. Cells were treated with resveratrol at 0 ~ 200 μM for 72 hours and applied to MTS assay. (B) HCT116 cells were treated with 5-FU at 0~200 μM for 72 hours. (C)HCT116 cells were treated with resveratrol at 0 ~ 200 μM combined with 5-FU at 10 μM for 72 hours and applied to MTS assay. (D) DLD1 cell proliferation assay with resveratrol at 0 ~ 200 μM for 72 hours. (E) DLD1 cells were treated with 5-FU at 0~ 200 μM for 72 hours. (F) DLD1 cells were treated with resveratrol combined with 5-FU at 10 μM for 72 hours. Error bars represent standard deviation.

25965911 30250641
In vivo Adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. [1] 100mg/kg Adrucil significantly suppresses tumor growth of murine colon carcinomas Colon 38 with tumor-doubling time (TD), growth-delay factor (GDF), and T/C of 26.5 days, 4.4, and 14%. [5]

Protocol

Cell Research:[4]
- Collapse
  • Cell lines: Human colon carcinoma cell line HT-29
  • Concentrations: ~25 μM
  • Incubation Time: 7 days
  • Method: Growth inhibition is measured after treatment of cells with Adrucil for 7 days in 96-well plates (4000 HT-29 cells/well in RPMI 1640 medium with 10% dialyzed fetal bovine serum); increasing concentrations of Adrucil are added after allowing for cell attachment overnight. At the end of incubation, cells are rinsed three times with phosphate-buffered saline (pH 7.4), fixed with 10% trichloroacetic acid for 60 min at 4 ℃, washed five times with deionized water, and stained with 0.4% sulforhoda-mine B solution for 15 min at room temperature. Unstained sulforhodamine B is removed by rinsing with 1% glacial acetic acid. Afterwards, stained cell proteins are dried and dissolved with 10 mM Tris-HCl. The optical density value is measured using a detector at 540 nm wavelength.
    (Only for Reference)
Animal Research:[5]
- Collapse
  • Animal Models: Murine colon carcinomas Colon 38
  • Dosages: 100 mg/kg
  • Administration: i.p. weekly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 26 mg/mL (199.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
saline (warming)
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 130.08
Formula

C4H3FN2O2

CAS No. 51-21-8
Storage powder
in solvent
Synonyms NSC 19893
Smiles C1=C(C(=O)NC(=O)N1)F

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04274790 Not yet recruiting Procedure: Scheduled and planned surgery Cancer of Colon|Metastasis to Liver Centre Leon Berard June 1 2021 --
NCT04825288 Not yet recruiting Biological: XB2001 or Placebo Pancreatic Cancer XBiotech Inc. April 19 2021 Phase 1|Phase 2
NCT04370418 Not yet recruiting Drug: short course chemo-radiation with 5-fluorouracil Neo-adjuvant Short Course Chemo-radiation in Locally Advanced Cancer Rectum Assiut University May 2020 --

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  • Question 1:

    I was wondering if the product #s1209 (5-fluorouracil) is suitable to inject into mice ?

  • Answer:

    S1209 is suitable to inject (I.P.) into mice as indicating in this paper: http://www.ncbi.nlm.nih.gov/pubmed/8995503.

DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID