RGX-202

RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo.

RGX-202 Chemical Structure

RGX-202 Chemical Structure

CAS No. 353-09-3

Purity & Quality Control

Batch: E122301 Water]26 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99%
99

RGX-202 Related Products

Biological Activity

Description RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03597581 Recruiting
Gastrointestinal Cancer|Gastrointestinal Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Gastric Cancer|Gastric Neoplasm|KRAS Mutation-Related Tumors|CRC|Colorectal Cancer Metastatic
Inspirna Inc.
June 5 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 131.13 Formula

C4H9N3O2

CAS No. 353-09-3 SDF --
Smiles NC(=N)NCCC(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 26 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy RGX-202 | RGX-202 supplier | purchase RGX-202 | RGX-202 cost | RGX-202 manufacturer | order RGX-202 | RGX-202 distributor