Niraparib (MK-4827) tosylate

For research use only.

Catalog No.S7625 Synonyms: Niraparib tosylate, MK 4827 tosylate, ZEJULA

14 publications

Niraparib (MK-4827) tosylate Chemical Structure

CAS No. 1038915-73-9

Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.

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Selleck's Niraparib (MK-4827) tosylate has been cited by 14 publications

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  • Berberine activates PARP1 in ovarian cancer cells. PAR synthesis is detected by immunofluorescence staining in A2780 and HO8910 treated with different concentration of berberine alone or in combination with niraparib (10 μM) for 48 h. Top: representative examples of immunofluorescence staining of PAR. Scale bar, 20 μm. Bottom: quantification of PAR level in A2780 and HO8910. Immunofluorescence intensities were quantified by ImageJ. *P<0.05, **P<0.01

    Cell Death & Disease, 2017, 8: e3070. Niraparib (MK-4827) tosylate purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.
PARP2 [3]
(Cell-free assay)
PARP1 [3]
(Cell-free assay)
2.1 nM 3.8 nM
In vitro

Micromolar concentrations of niraparib radiosensitizes tumor cell lines derived from lung, breast, and prostate cancers independently of their p53 status but not cell lines derived from normal tissues. Niraparib also sensitizes tumor cells to H2O2 and converts H2O2-induced single strand breaks (SSBs) into DSBs during DNA replication[5].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NXrM[446WHKxbHnm[ZJifGmxbjDhd5NigQ>? MljwO{Bl[Xm| NWXXTow6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKUQ1GxJIFnfGW{IEeg[IF6eyCkeTDj[YxtKHSrdHXyMYJtfWViYYPzZZktKEOFNUC9NE45PiEQvF2= M3S2SFE6QDd|OUix
MDA-MB-436 NIXqPG1Rem:uaX\ldoF1cW:wIHHzd4F6 MlXSOkBl[Xm| NF7IOXRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{[gZ4VtdHNiZYjwdoV{e2mwZzDCVmNCOSB3M{m2JEshOUd-QTDteZRidnRiYX\0[ZIhPiCmYYnzJIJ6KGOnbHygeIl1\XJvYnz1[UBie3OjeTygR2M2OD1yLkCxPEDPxE1? MkX2NVk5PzN7OEG=
Capan1 NGnZbFJRem:uaX\ldoF1cW:wIHHzd4F6 NF7kc|IyOyCmYYnz NVLGd4R[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDZZBidjFiY3XscJMh\XiycnXzd4lv\yCEUlPBNkA3OTd2ZHXsWEBufXSjdHnvckBidmRibH;zd{Bw\iC5aXzkMZR6eGViYXzs[YxmKGGodHXyJFE{KGSjeYOgZpkh[2WubDD0bZRmei2kbIXlJIF{e2G7LDDDR|UxRTBwMEmg{txO M1HhSlE6QDd|OUix
Jurkat MWjGeY5kfGmxbjDhd5NigQ>? NFW2UIo6PiCq MnzRTY5pcWKrdHnvckBw\iCSQWLQNUBqdiCqdX3hckBLfXKtYYSgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IEm2JIhzeyCkeTDNWHMh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiMUCwJJVOKG:oIITlcY97d2yxbXnk[UwhTUN3ME2wMlIh|ryP M1zRNlI{QDVyMUm5
SUM149PT MmTlR5l1d3SxeHnjbZR6KGG|c3H5 MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTWW0yPDmSVDDj[YxteyClYYLyfYlv\yCEUlPBNUBufXSjboSgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNTD0c{A4KGSjeYOgZpkhS2WubGTpeIVzNUKudXWgZZN{[XluIFPDOVA:OC5yMkSg{txO MkewNlU4PjFyOU[=
SUM1315MO2 NEDLe|dEgXSxdH;4bYNqfHliYYPzZZk> NH;CfJREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXU1zM{G1UW8zKGOnbHzzJINienK7aX7nJGJTS0FzIH31eIFvfCCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkAyOiCmYYnzJIJ6KEOnbHzUbZRmei2EbIXlJIF{e2G7LDDDR|UxRTBwMEKg{txO NETie|IzPTd4MUC5Oi=>
UWB1.289 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MlPxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWXdDOS5{OEmgZ4VtdHNiZYjwdoV{e2mwZzDCVmNCOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA2KHSxIEeg[IF6eyCkeTDD[YxtXGm2ZYKtRox2\SCjc4PhfUwhS0N3ME2wMlk4PSEQvF2= NF7YRVkzPTd4MUC5Oi=>
DoTc2-4510 NIfNcHpEgXSxdH;4bYNqfHliYYPzZZk> MofkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSI9V[zJvNEWxNEBk\WyuczDjZZJzgWmwZzDCVmNCOiCvdYThcpQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOUB1dyB5IHThfZMh[nliQ3XscHRqfGW{LVLseYUh[XO|YYm= MnLUNlU4PjFyOU[=
A549 MoCwR5l1d3SxeHnjbZR6KGG|c3H5 NGrE[ldEgXSxdH;4bYNqfHliYXfhbY5{fCC5aXzkJJR6eGViaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA2KHSxIEeg[IF6eyCkeTDD[YxtXGm2ZYKtRox2\SCjc4PhfS=> MWSyOVc3OTB7Nh?=
BT20 Ml3JR5l1d3SxeHnjbZR6KGG|c3H5 NWDEUYIxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSlR{MDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA2KHSxIEeg[IF6eyCkeTDD[YxtXGm2ZYKtRox2\SCjc4PhfS=> NIX6U5AzPTd4MUC5Oi=>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
c-PARP /c-caspase 3 / γ-H2AX; 

PubMed: 29158830     

Western Blot data testing protein expression after treatment with Olaparib, Niraparib, and Talazoparib on Brca1-deficient cell line in W0069 cells.

Rad51 / Geminin; 

PubMed: 27614696     

Immunofluorescence microscopy of niraparib-treated PDX cells (PH039) and irradiated cells showing RAD51 foci (arrow) within geminin positive cells and lack of RAD51 foci formation in control cells. 

In vivo MK-4827 strongly enhances the effect of radiation on a variety of human tumor xenografts, both p53 wild type and p53 mutant. MK-4827 reduces PAR levels in tumors by 1 h after administration which persisted for up to 24 h[1]. In vivo treatment with MK-4827 and radiation prolonged survival (p<0.01) compared to single modalities. In vivo superiority of MK-4827 plus radiation is further documented by significant elevations of cleaved caspase-3 and γ-H2AX in tumors from the combination group compared to single modality cohorts[4].


Cell Research:


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  • Cell lines: V-C8 cells
  • Concentrations: 50 nM
  • Incubation Time: 24 h
  • Method:

    V-C8 (BRCA2-negative) Chinese hamster cells are treated with the PARP inhibitor MK-4827 for 24 h, washed and incubated in drug-free medium for 5-7 days until colonies formed.

    (Only for Reference)
Animal Research:


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  • Animal Models: Female nude mice (Ncr Nu/Nu)
  • Dosages: 25 or 50 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 98 mg/mL (198.94 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 492.59


CAS No. 1038915-73-9
Storage powder
in solvent
Synonyms Niraparib tosylate, MK 4827 tosylate, ZEJULA
Smiles CC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

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PARP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID