Pemetrexed (LY-231514) disodium

For research use only.

Catalog No.S1135

32 publications

Pemetrexed (LY-231514) disodium Chemical Structure

CAS No. 150399-23-8

Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

Size Price Stock Quantity  
USD 120 In stock
USD 470 In stock
USD 970 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Pemetrexed (LY-231514) disodium has been cited by 32 publications

Purity & Quality Control

Choose Selective DHFR Inhibitors

Biological Activity

Description Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Targets
TS [1]
(Cell-free assay)
DHFR [1]
(Cell-free assay)
GARFT [1]
(Cell-free assay)
1.3 nM(Ki) 7.2 nM(Ki) 65 nM(Ki)
In vitro

Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of 25 nM, 34 nM and 220 nM, respectively. [1] A recent study shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vector. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PANC-1 NX\LdokzTnWwY4Tpc44hSXO|YYm= MlHsPFQh|ryP MX6yOEBp NULGfoZY\W6qYX7j[ZMhTUeIUjygTGVTOyCjbnSgRWtVKHCqb4PwbI9zgWyjdHnvckBt\X[nbIO= NY\3NnBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5O|c3ODdpPkKyPVc4PjB5PD;hQi=>
BXPC-3 MXTGeY5kfGmxbjDBd5NigQ>? MX2zPU45PiBizszN NFjWb3YzPCCq MVflcohidmOnczDFS2ZTNCCKRWKzJIFv\CCDS2SgdIhwe3Cqb4L5cIF1cW:wIHzleoVtew>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5N{[wO{c,OjJ7N{e2NFc9N2F-
PANC-1 M4fkd2Z2dmO2aX;uJGF{e2G7 MWS4OEDPxE1? MknuNlQhcA>? NUO5elln\W6qYX7j[ZMhTUeIUjDwbI9{eGixconsZZRm\CCuZY\lcJMtKGGwZDD0bIUheHKxdHXpckBt\X[nbIRCpC=> NW\MOWVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5O|c3ODdpPkKyPVc4PjB5PD;hQi=>
BXPC-3 NV3hPVN2TnWwY4Tpc44hSXO|YYm= MnHvN|kvQDZiIN88US=> NFK1PJQzPCCq M3HrXIVvcGGwY3XzJGVITlJicHjvd5Bpd3K7bHH0[YQhdGW4ZXzzMEBidmRidHjlJJBzd3SnaX6gcIV3\Wy|wrC= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5N{[wO{c,OjJ7N{e2NFc9N2F-
BXPC-3 NXPS[oZsTnWwY4Tpc44hSXO|YYm= MYqzPU45PiBizszN NYe4d4VoOjRiaB?= NX;2cm1wcW6mdXPld{BUKGG{cnXzeEApWDxyLkC1LUBidmRiZHXjdoVie2W|IITo[UBvfW2kZYKgc4Yh[2WubIOgbY4hfGinIFeyM20heGijc3ZCpC=> NXz0[4JLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5O|c3ODdpPkKyPVc4PjB5PD;hQi=>
PANC-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHZTWM2OD16Mz63OuKyOC5zOTFOwG0> M3zVT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUe3OlA4Lz5{Mkm3O|YxPzxxYU6=
BXPC-3 M{G0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Tvc2lEPTB;M{muPFbDuTFwNkig{txO NF36UYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3O|YxPyd-MkK5O|c3ODd:L3G+
Jurkat NF\mRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTVVGo1QCCq M1LmU5Bzd3CxcoTpc44hd2ZibHn2[UBk\Wyuc{23Ok44yrF2LkOgKS=> NIjwW4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0NFM4Pid-MkO4OFA{PzZ:L3G+
DM-3 M2nhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\0U2NpPDhiaB?= NWLyXWRbeHKxcH;yeIlwdiCxZjDsbZZmKGOnbHzzQVExOS5|wsGyMlghLQ>? M1TRSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OESwN|c3Lz5{M{i0NFM4PjxxYU6=
JL-1 NHHVflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfhVW5zPDhiaB?= M1GzepBzd3CxcoTpc44hd2ZibHn2[UBk\Wyuc{25PE4zyrF{LkKgKS=> NGrVT4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0NFM4Pid-MkO4OFA{PzZ:L3G+
ZL-34 M1\sdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml61OFghcA>? NV\TdldTeHKxcH;yeIlwdiCxZjDsbZZmKGOnbHzzQVk2NjgEsU[uOUAm NGTYdIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0NFM4Pid-MkO4OFA{PzZ:L3G+
STAV-FCS NWq0d3FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TmdFQ5KGh? MYTwdo9xd3K2aX;uJI9nKGyrdnWgZ4VtdHN;OEiuNeKyQC57IDW= M1fZ[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OESwN|c3Lz5{M{i0NFM4PjxxYU6=
M-14-K NYHiUZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nZTFQ5KGh? M1j6NJBzd3CxcoTpc44hd2ZibHn2[UBk\Wyuc{24NU45yrFzMj65JEU> NXnDVmViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OFA{PzZpPkKzPFQxOzd4PD;hQi=>
STAV-AB NFXVTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLuOFghcA>? MU\wdo9xd3K2aX;uJI9nKGyrdnWgZ4VtdHN;NkSuOOKyOjFwODCl Ml[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NECzO|YoRjJ|OESwN|c3RC:jPh?=
LoVo M4nIUmZ2dmO2aX;uJGF{e2G7 M3HTelAvODYEoN88US=> NFTDSXA4OsLiaB?= M{n6b2ROW00EoB?= M{ixSYlv[3KnYYPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckB1cGViUzDwbIF{\cLi M1;MOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUW5OFYxLz5{M{m1PVQ3ODxxYU6=
HT-29 MVfGeY5kfGmxbjDBd5NigQ>? MVywMlA2yqEQvF2= MlTyO|LDqGh? MWDEUXNQyqB? MUHpcoNz\WG|ZYOgeIhmKHCncnPlcpRi\2Vib3[gZ4VtdHNiaX6geIhmKFNicHjhd4XDqA>? NGfETW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1PVQ3OCd-MkO5OVk1PjB:L3G+
WiDr MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\2dFdDPzMEoHlCpC=> MX7EUXNQyqB? M1G2SmlEPTB;MD6wNVkhyrFiMD6wNFIh|ryP NFjXR3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1PVQ3OCd-MkO5OVk1PjB:L3G+
SW1116 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XlTVczyqCqwrC= M2LBcmROW00EoB?= NH7DbpVKSzVyPUGuO|AhyrFiMD6wN{DPxE1? MnHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NUm0OlAoRjJ|OUW5OFYxRC:jPh?=
HCT116 NVeyOnpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq3VlE4OsLiaNMg M2r1VmROW00EoB?= MW\JR|UxRTBwMES5JOKyKDBwMEGzJO69VQ>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl3OUS2NEc,OjN7NUm0OlA9N2F-
SW620 NXv0bFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrYZYN5PzMEoHlCpC=> NV2zc4IyTE2VT9Mg NWH1dpBkUUN3ME2xMlA6KMLzIECuNFEh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl3OUS2NEc,OjN7NUm0OlA9N2F-
LoVo MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Dq[|czyqCqwrC= M2DESWROW00EoB?= MnHKTWM2OD1yLkCzNkDDuSByLkCwNkDPxE1? MoPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NUm0OlAoRjJ|OUW5OFYxRC:jPh?=
HT-29 M{LIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK3NuKhcMLi NFy5TFRFVVORwrC= M3LqcmlEPTB;MUCuNFchyrFiMD65OEDPxE1? NIjKWlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1PVQ3OCd-MkO5OVk1PjB:L3G+
A549/PEM-16 M4njNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVGwOnd6QTZiaB?= MWjJR|UxRTVzLkS1JO69VQ>? NGHhbGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0PFg2PCd-MkSzOFg5PTR:L3G+
A549/PEM-6.4 M1K5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUbWdWQTZiaB?= MVzJR|UxRTJ|LkO5JO69VQ>? NH7GbGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0PFg2PCd-MkSzOFg5PTR:L3G+
A549/PEM-1.6 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUG5OkBp NUXkboVJUUN3ME21MlA{KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN2OEi1OEc,OjR|NEi4OVQ9N2F-
A549 NH\jRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrqPVYhcA>? MVHJR|UxRTFwM{Wg{txO NWfwRmJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOFg5PTRpPkK0N|Q5QDV2PD;hQi=>
MSTO-211H MVPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NXjNN4k5OS1zMDFOwIcwdWx? MV[3NkBp NI\iVnJKSzVyfkCuNFQh|rypL33s NITGXoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3PFU4Pid-MkSzO|g2PzZ:L3G+
Y-meso14 MXzD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MoHBNU0yOCEQvHevcYw> Mn\0O|IhcA>? NHXISmlKSzVyPkGwJO69\y:vbB?= MoPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|N{i1O|YoRjJ2M{e4OVc3RC:jPh?=
H290 MlTTR4VtdCCYaXHibYxqfHliQYPzZZk> NFP6N|YyNTFyIN88[{9udA>? M1LBRlczKGh? MkHZTWM2OD5zMDFOwIcwdWx? NWrmVnVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO|g2PzZpPkK0N|c5PTd4PD;hQi=>
H226 MXXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MoTGNU0yOCEQvHevcYw> MW[3NkBp MYrJR|UxRjFyIN88[{9udA>? M{LYZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{e4OVc3Lz5{NEO3PFU4PjxxYU6=
H1299 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwOESg{txO M4DRPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG4OVE6Lz5{NESxPFUyQTxxYU6=
H1993 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMUeg{txO M3n6UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG4OVE6Lz5{NESxPFUyQTxxYU6=
A549 NHTweWlHfW6ldHnvckBCe3OjeR?= NWPwb|hvOC5zL{CuN{8xNjVxMTFOwG0> Ml\oNlQwPDhiaB?= MXrEUXNQ M3LSXpBzd2S3Y3XzJJRp\SCob4LtZZRqd25ib3[gRXZQeyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NH\ZNYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[yOlczOid-MkS2NlY4OjJ:L3G+
A549 NFHoXZVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MkDWNE4yNzBwMz:wMlUwOSEQvF2= MkLZNlQwPDhiaB?= M37TXmROW09? NH3se2JqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 NHuwUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[yOlczOid-MkS2NlY4OjJ:L3G+
MES04 M{Hncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rNUWlEPTExvK6xNFAh|ryP MkjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MUS3NlIoRjJ2N{G0O|IzRC:jPh?=
MES01 M3[2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnDV5hMUUN3MP-8olExOCEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDdzNEeyNkc,OjR5MUS3NlI9N2F-
H2452 M{S4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHzTWM2OO,:nkGwNEDPxE1? NEPHNW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEexOFczOid-MkS3NVQ4OjJ:L3G+
H2052 NVLWVVNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j0TmlEPTB;MD61O:KyOC5|NDFOwG0> NH;lNY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEexOFczOid-MkS3NVQ4OjJ:L3G+
211H M4nnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTtR2JUUUN3ME2wMlA4yrFyLkCxJO69VQ>? MoDqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MUS3NlIoRjJ2N{G0O|IzRC:jPh?=
H28 M3nkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu0TWM2OD1yLkC3xtExNjB{IN88US=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDdzNEeyNkc,OjR5MUS3NlI9N2F-
PC9/GR MlnKSpVv[3Srb36gRZN{[Xl? NVK0VoJnPC57NDFOwG0> MlzwO|IhcA>? MWDpcoNz\WG|ZYOgdE1CU1RibHX2[Yx{ NV3TUplmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFA5QTFpPkK0PFQxQDlzPD;hQi=>
PC9/GR MXLGeY5kfGmxbjDBd5NigQ>? MlPJOE46PCEQvF2= NXe0S5dRPzJiaB?= M4\udYlv[3KnYYPld{BxNUWUSzDs[ZZmdHN? M4PRN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OESwPFkyLz5{NEi0NFg6OTxxYU6=
PC9/GR NI\6RXVCeG:ydH;zbZMhSXO|YYm= NYTaenFyPC57NDFOwG0> NH;NUFI4OiCq M3\KXolv\HWlZYOgNVkvPTUxubqgZZBweHSxc3nz NYGwZmd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFA5QTFpPkK0PFQxQDlzPD;hQi=>
PC9 MnP5RZBweHSxc3nzJGF{e2G7 MmqzNVYhdk1? M{frU|czKGh? NV[zZnZYcW6mdXPld{AyPC53NP-5rkBieG:ydH;zbZM> MnjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NEC4PVEoRjJ2OESwPFkyRC:jPh?=
PC9/GR MlLKSpVv[3Srb36gRZN{[Xl? MXO0Mlk1KM7:TR?= M1vWclczKGh? MnfObY5lfWOnczDTMZBp[XOnIHHydoV{fA>? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh2MEi5NUc,OjR6NEC4PVE9N2F-
PC9 MmLMSpVv[3Srb36gRZN{[Xl? NUjyUXA6OTZibl2= NUj6VXI{PzJiaB?= MmjpbY5lfWOnczDTMZBp[XOnIHHydoV{fA>? NHvaXYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0NFg6OSd-MkS4OFA5QTF:L3G+
PC9/GR NE\PUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[3NkBp M2[yb2lEPTB;ND65OOKyOC52NECg{txO M2X5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OESwPFkyLz5{NEi0NFg6OTxxYU6=
PC9 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK3NkBp MVrJR|UxRTF4LkC1xtEyNjh3IH7N NXLYXpBGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFA5QTFpPkK0PFQxQDlzPD;hQi=>
A549 M1jle2Z2dmO2aX;uJGF{e2G7 Mk\HNE4yNzBwMz:xJO69VQ>? M{\Ic|Q5KGh? MluwbY5kemWjc3XzJJRp\SC{YYTpc{Bw\iCVLYDoZZNmKHCxcIXsZZRqd25? M1LTNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OES3PFY{Lz5{NEi0O|g3OzxxYU6=
A549 MYHBdI9xfG:|aYOgRZN{[Xl? NV[1XZJ{OC5zL{CuN{8yKM7:TR?= MVO0PEBp M4rwVYlv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh2N{i2N{c,OjR6NEe4OlM9N2F-
A549 M1\EcmZ2dmO2aX;uJGF{e2G7 M3rnWVAvOS9yLkOvNUDPxE1? NV7iblV7PDhiaB?= NVHyfmQ{cW6lcnXhd4V{KHSqZTDs[ZZmdCCxZjDwbI9{eGixconsZZRm\CCDa4SgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NHL2b2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0O|g3Oyd-MkS4OFc5PjN:L3G+
A549 NITXNZZHfW6ldHnvckBCe3OjeR?= NIG4doQyKML3TR?= NWjGTINOPC96L{GyM|I1NzR6IHi= M4e2PIlv[3KnYYPld{B1cGVibHX2[Ywhd2ZicHjvd5Bpd3K7bHH0[YQhSWu2IHnuJIEhfGmvZTDk[ZBmdmSnboSgcYFvdmW{ NG\BXJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0O|g3Oyd-MkS4OFc5PjN:L3G+
A549 Mo\vSpVv[3Srb36gRZN{[Xl? NEL3T|A2KM7:TR?= NGnFTWg5KGh? MXHpcoNz\WG|ZYOgUYNtNTFidXLpdZVqfGmwYYTpc44hdGW4ZXzz NHrX[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5NVc3QCd-MkS5PVE4Pjh:L3G+
A549 NUfxXJhYSXCxcITvd4l{KEG|c3H5 MW[yMlUh|ryP NUDOSpZTPDhiaB?= MXPpcoR2[2W|IHHwc5B1d3Orcx?= NYfNNXl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVE4PjhpPkK0PVkyPzZ6PD;hQi=>
H1792 MYHGeY5kfGmxbjDBd5NigQ>? MkDiNk42NzVxMUCg{txO NEXJWmg1QCCq NWTj[ZU3\G:5boLl[5Vt[XSnczDNZ4wuOcLi Mn\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUG3OlgoRjJ2OUmxO|Y5RC:jPh?=
A549  NYnUcY1FTnWwY4Tpc44hSXO|YYm= M{i5WFIvPS93L{GwJO69VQ>? MWm0PEBp NF\ZO2dld3ewcnXneYxifGW|IF3jcE0yyqB? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7MUe2PEc,OjR7OUG3Olg9N2F-
H1792 NYmwZVl4TnWwY4Tpc44hSXO|YYm= MlLYNk42KM7:TR?= MoOyOFghcA>? Mnn3bY5lfWOnczDjZZNx[XOnLUmsJINie3Cjc3WtN{BidmRicH;sfUApSUSSLYLpZo9{\SlicH;sfY1memG|ZTCoVGFTWCliY3zlZZZi\2V? MlfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUG3OlgoRjJ2OUmxO|Y5RC:jPh?=
A549  MUnGeY5kfGmxbjDBd5NigQ>? MUmyMlUh|ryP NGjwO5I1QCCq NIPLSIxqdmS3Y3XzJINie3Cjc3WtPUwh[2G|cHHz[U0{KGGwZDDwc4x6KCiDRGCtdoljd3OnKTDwc4x6dWW{YYPlJEhRSVKSKTDjcIVifmGpZR?= MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUG3OlgoRjJ2OUmxO|Y5RC:jPh?=
H1792 MlrXSpVv[3Srb36gRZN{[Xl? MoOzNk42NzVxMUCg{txO MVe0PEBp NHHwSJZqdmO{ZXHz[ZMhVm:6YTDlfJBz\XO|aX;uJJNq\26rZnnjZY51dHl? M{nlblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUmxO|Y5Lz5{NEm5NVc3QDxxYU6=
A549  MVvGeY5kfGmxbjDBd5NigQ>? NUjVWZl6Oi53L{WvNVAh|ryP M3XVRlQ5KGh? NXfWeJFWcW6lcnXhd4V{KE6xeHGg[ZhxemW|c3nvckB{cWewaX\pZ4FvfGy7 MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7MUe2PEc,OjR7OUG3Olg9N2F-
A549 M4\IWWZ2dmO2aX;uJGF{e2G7 MXGxJO69VQ>? M4HJcFQ5KGh? M{Wx[oxm[WS|IITvJI1qfG:laH;u[JJq[WxiZInz[pVv[3Srb36gZ49u[mmwZXSge4l1cCC|aX32ZZN1[XSrbh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB7Nkm5N{c,OjVyOU[5PVM9N2F-
MSTO-211 MXXGeY5kfGmxbjDBd5NigQ>? MX[xJO69VQ>? M{jHXFQ5KGh? NHnIZnRt\WGmczD0c{BucXSxY3jvcoRzcWGuIHT5d4Z2dmO2aX;uJINwdWKrbnXkJJdqfGhic3nteoF{fGG2aX6= MmLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOU[5PVMoRjJ3MEm2PVk{RC:jPh?=
A549 NWjlZ494TnWwY4Tpc44hSXO|YYm= NWHsdWRDOSEQvF2= M{nhPVQ5KGh? MmXm[Y5p[W6lZYOgbY51emGlZXzseYxieiCUT2OgdJJw\HWldHnvckBkd22kaX7l[EB4cXSqIIPpcZZie3SjdHnu NYjUfXpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVY6QTNpPkK1NFk3QTl|PD;hQi=>
MSTO-211 MlfwSpVv[3Srb36gRZN{[Xl? M{PPNFEh|ryP NUXjPHhUPDhiaB?= Mn7j[Y5p[W6lZYOgbY51emGlZXzseYxieiCUT2OgdJJw\HWldHnvckBkd22kaX7l[EB4cXSqIIPpcZZie3SjdHnu MojXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOU[5PVMoRjJ3MEm2PVk{RC:jPh?=
A549 NF\FdmpCeG:ydH;zbZMhSXO|YYm= MnzrNUDPxE1? Mln4OFghcA>? MX;lcohidmOnczDjZZNx[XOnLXTldIVv\GWwdDDhdI9xfG:|aYOgZ49u[mmwZXSge4l1cCC|aX32ZZN1[XSrbh?= M2e3elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEm2PVk{Lz5{NUC5Olk6OzxxYU6=
MSTO-211 MXLBdI9xfG:|aYOgRZN{[Xl? NGPyPYYyKM7:TR?= MUS0PEBp Mn\q[Y5p[W6lZYOgZ4F{eGG|ZT3k[ZBmdmSnboSgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhic3nteoF{fGG2aX6= MnXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOU[5PVMoRjJ3MEm2PVk{RC:jPh?=
A549 NInwUYJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXLBXotiOSEQvF2= MmnQOFghcA>? MVnwdo9lfWOnczDhJJN6dmW{Z3nzeIlkKGmwaHnibZRwenliZX\m[YN1KG:wIITo[UBk\WyuIHfyc5d1cCClb33ibY5m\CC5aYToJJNqdX[jc4TheIlv NUXCb2xQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVY6QTNpPkK1NFk3QTl|PD;hQi=>
MSTO-211 MljzR4VtdCCYaXHibYxqfHliQYPzZZk> MVKxJO69VQ>? NEOzcJQ1QCCq MULwdo9lfWOnczDhJJN6dmW{Z3nzeIlkKGmwaHnibZRwenliZX\m[YN1KG:wIITo[UBk\WyuIHfyc5d1cCClb33ibY5m\CC5aYToJJNqdX[jc4TheIlv M2\teVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEm2PVk{Lz5{NUC5Olk6OzxxYU6=
H1299 MkTaR4VtdCCYaXHibYxqfHliQYPzZZk> MVuxMVExODBibl2= NETiT5Q4OiCq M1ryT2lEPTB;MUe4JI5O M4fPXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS1OlY6Lz5{NUG0OVY3QTxxYU6=
A549 MkjFR4VtdCCYaXHibYxqfHliQYPzZZk> MVOxMVExODBibl2= MYC3NkBp MkDDTWM2OD1zM{egcm0> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF2NU[2PUc,OjVzNEW2Olk9N2F-
MG-63 M3TKc2NmdGxiVnnhZoltcXS7IFHzd4F6 M3T6flAvODFvMUCwJO69VQ>? NHTxR2s4OiCq M1S5UYlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Vl\XCnbnTlcpRtgQ>? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF3MkO5PUc,OjVzNUKzPVk9N2F-
U20S NIG1c|RE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NFfHV3gxNjBzLUGwNEDPxE1? NGnMbYc4OiCq M2DtVYlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Vl\XCnbnTlcpRtgQ>? NHjMdGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG1NlM6QSd-MkWxOVI{QTl:L3G+
HepG3 NHHxOmtHfW6ldHnvckBCe3OjeR?= NYX0VopWOTEEoN88US=> NXXnPWtCPDhiaB?= M4LCRZVxemWpdXzheIV{KHCqb4PwbI9zgWyjdHXkJEhxNSliTVXLNU8zKCiVZYKyNVcwOjJzKTDhcoQheC2HUluxM|IhMFSqckKwNk9VgXJ{MESp NFzsVlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS0OlExOid-MkW0OFYyODJ:L3G+
HepG3 MlXxSpVv[3Srb36gRZN{[Xl? MoHSNE4y6oDVMUCwxsDPxE1? MoPxOFghcA>? MVLhZ5RqfmG2ZYOgZ5l1dy2ycn;0[YN1cX[nIHH1eI9xcGGpedMg MonMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NE[xNFIoRjJ3NES2NVAzRC:jPh?=
HepG3 NVrz[Y5yTnWwY4Tpc44hSXO|YYm= MXGwMlHjiJNzMEFCpO69VQ>? MYq0PEBp MW\pcoR2[2W|IIC2NkBld3ewcnXneYxifGmxbjDhd{B4\WyuIHHzJGJm[2yrbj2xJIFv\CCOQ{PCMWlKKHWycnXneYxifGmxbh?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR2NkGwNkc,OjV2NE[xNFI9N2F-
HepG2 NIjJNYlCeG:ydH;zbZMhSXO|YYm= MnHwNE4y6oDVMUCwxsDPxE1? NFL6d5M4OiCq NUL5UlJxcW6mdXPld{BieG:ydH;zbZMhe2yrZ3j0cJkh[XRiaHnnbEBkd26lZYLueJJifGmxbh?= M3zZ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NES2NVAzLz5{NUS0OlExOjxxYU6=
HepG2 NX3Wd3V3S2WubDDWbYFjcWyrdImgRZN{[Xl? MlfFNE4y6oDVMUCwxsDPxE1? M{DpXlczKGh? M3\z[Yhq\2hiY3;uZ4VvfHKjdHnvcpMhd2ZicHXt[ZRz\XinZDDheEApOTBxMUCwxsDPxE1rIH;ucJkhe2yrZ3j0cJkhcW6qaXLpeJMhUGWyR{KgZ4VtdCC|dYL2bZZidA>? M2HIOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NES2NVAzLz5{NUS0OlExOjxxYU6=
A459 MmDSRZBweHSxc3nzJGF{e2G7 MoK1OO69VQ>? M1zUVFQ5KGh? MYPpcoR2[2W|IHHwc5B1d3Orcx?= M{nKNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{SzPFIzLz5{NUe0N|gzOjxxYU6=
A459 NIT2PVRHfW6ldHnvckBCe3OjeR?= MmnVNU8zNzRizszN M2TCVlQ5KGh? NWTQ[m1M\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdE1Cc3R? M1iwUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{SzPFIzLz5{NUe0N|gzOjxxYU6=
A459 Ml\HSpVv[3Srb36gRZN{[Xl? NUDufHp6OS9{L{Sg{txO M1exTlI1NzR6IHi= NXX3XWR5cW6mdXPld{BIOSCyaHHz[UBienKnc4SgbY4h\G:|ZT2gZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= NHPsTlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0N|gzOid-MkW3OFM5OjJ:L3G+
T47D NUH2UZN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO2elFsOC5{M{VCpI1O MmLsO|IhcA>? NHPTXndoem:5dHigbY5pcWKrdHnvcl0{OO,7qh?= NGLnR|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm3OVY{Pyd-MkW5O|U3Ozd:L3G+
HeLa NULnRYZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVWwMlI{PMLibV2= M4jqelczKGh? MUDndo94fGhiaX7obYJqfGmxbk2yNQ+6sg>? NGPLdm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm3OVY{Pyd-MkW5O|U3Ozd:L3G+
A549 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnBb5IxNjJ|NNMgcW0> MlXRO|IhcA>? NXTpflFW\3Kxd4ToJIlvcGmkaYTpc44:PTExubq= M3O1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUe1OlM4Lz5{NUm3OVY{PzxxYU6=
Vero NXzEVpZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn5TFd4OC5{M{VCpI1O NHnxV2Y4OiCq Ml64[5Jwf3SqIHnubIljcXSrb369NlDwwap? M4nEOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUe1OlM4Lz5{NUm3OVY{PzxxYU6=
T47D M2nETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\5elAvOjN2wrDtUS=> NXnw[ZNwPDhiaB?= MlL5[5Jwf3SqIHnubIljcXSrb369NlDwwap? M2jIRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUe1OlM4Lz5{NUm3OVY{PzxxYU6=
HeLa NX3aZYhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlI{PMLibV2= MYO0PEBp M2G3Vodzd3e2aDDpcohq[mm2aX;uQVEx97ns NVLIRVZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O|U3OzdpPkK1PVc2PjN5PD;hQi=>
A549 M{\iPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[wMlI{PMLibV2= NVXQVI9GPDhiaB?= MX3ndo94fGhiaX7obYJqfGmxbk2zNQ+6sg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl5NU[zO{c,OjV7N{W2N|c9N2F-
Vero NIKxbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHi[VgxNjJ|NNMgcW0> MVO0PEBp NEjjb5Noem:5dHigbY5pcWKrdHnvcl0yOO,7qh?= NIfjc4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm3OVY{Pyd-MkW5O|U3Ozd:L3G+
T47D NIPSUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL1NE4zOzUEoH3N M4nqe|I1KGh? Mmi5[5Jwf3SqIHnubIljcXSrb369NVDwwap? MljmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7N{W2N|coRjJ3OUe1OlM4RC:jPh?=
HeLa NIr2S2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jKV|AvOjN2wrDtUS=> MlnRNlQhcA>? MUXndo94fGhiaX7obYJqfGmxbk2189mr MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl5NU[zO{c,OjV7N{W2N|c9N2F-
A549 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfifmExNjJ|NNMgcW0> MUWyOEBp MUHndo94fGhiaX7obYJqfGmxbk2xNQ+6sg>? NHLsXXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm3OVY{Pyd-MkW5O|U3Ozd:L3G+
Vero MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmwMlI{PMLibV2= NY[2NY1{OjRiaB?= MkT4[5Jwf3SqIHnubIljcXSrb369Og+6sg>? MlvHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7N{W2N|coRjJ3OUe1OlM4RC:jPh?=
A549 NGe1OHJHfW6ldHnvckBCe3OjeR?= MUexJO69VQ>? M1fIVFQ5KGh? M1rjRYlv[3KnYYPld{BCVVCNIIDoc5NxcG:{eXzheIlwdiCjbnSgZUBkd26lb33peIFvfCCmZXPy[YF{\SCrbjDBT3Qh[W6mIH3UU3IheGixc4Doc5J6dGG2aX;uJINwfHKnYYTl[EB4cXSqIIPpcZZie3SjdHnu M3fxflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{O0N|IxLz5{NkOzOFMzODxxYU6=
MSTO-211H MWHGeY5kfGmxbjDBd5NigQ>? NYq2bZN6OSEQvF2= NXHRVJdlPDhiaB?= MmLUbY5kemWjc3XzJGFOWEticHjvd5Bpd3K7bHH0bY9vKGGwZDDhJINwdmOxbXn0ZY51KGSnY4LlZZNmKGmwIFHLWEBidmRibWTPVkBxcG:|cHjvdplt[XSrb36gZ491emWjdHXkJJdqfGhic3nteoF{fGG2aX6= M3vXfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{O0N|IxLz5{NkOzOFMzODxxYU6=
A549 MnqzRZBweHSxc3nzJGF{e2G7 NHrDOIkyKM7:TR?= M1jrdVI1KGh? M2q4SIlv\HWlZYOgZZBweHSxc3nzJINwfHKnYYTl[EB4cXSqIIPpcZZie3SjdHnu M1TJZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{O0N|IxLz5{NkOzOFMzODxxYU6=
MSTO-211H M2XSNmFxd3C2b4Ppd{BCe3OjeR?= MUmxJO69VQ>? NHn2PFEzPCCq M3vhdIlv\HWlZYOgZZBweHSxc3nzJINwfHKnYYTl[EB4cXSqIIPpcZZie3SjdHnu NHS0WZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzOFMzOCd-Mk[zN|Q{OjB:L3G+
A549 NHTHZ|JHfW6ldHnvckBCe3OjeR?= NIjzemQyKM7:TR?= NW\lfmZyOjRiaB?= MnPl[Y5p[W6lZYOgZZV1d3CqYXf5JINwfHKnYYTl[EB4cXSqIIPpcZZie3SjdHnu NYLrWYd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|Q{OjBpPkK2N|M1OzJyPD;hQi=>
MSTO-211H MXTGeY5kfGmxbjDBd5NigQ>? NEHifVgyKM7:TR?= MkDnNlQhcA>? NHv2OGJmdmijbnPld{BifXSxcHjh[5kh[2:2cnXheIVlKHerdHigd4lufmG|dHH0bY4> NHvOTHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzOFMzOCd-Mk[zN|Q{OjB:L3G+
A549 MmPHR4VtdCCYaXHibYxqfHliQYPzZZk> MoGzNUDPxE1? NInxd401QCCq MXflcohidmOnczDzbY13[XO2YYTpckBqdmirYnn0[YQhfmmjYnnsbZR6 M4Xjd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{O0N|IxLz5{NkOzOFMzODxxYU6=
MSTO-211H NGXHbHlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MoTLNUDPxE1? MUO0PEBp NFLSVZFmdmijbnPld{B{cW24YYP0ZZRqdiCrbnjpZol1\WRidnnhZoltcXS7 MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|NEOyNEc,OjZ|M{SzNlA9N2F-
KB MV7GeY5kfGmxbjDhd5NigQ>? M3TIOmlEPTBiPTCwMlA{KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3OUc,OTh4OECyO|U9N2F-
RT16 M2nsOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2nRcWlEPTBiPTCwMlA1OiEQvF2= MlK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|UoRjF6NkiwNlc2RC:jPh?=
D4 M4TNd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmryTWM2OCB;IECuNFYh|ryP NGDHTZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4PSd-MUi2PFAzPzV:L3G+
KB NIrlRVBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGDxenVKSzVyIE2gNE4xPjhizszN Mm\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|UoRjF6NkiwNlc2RC:jPh?=
IGROV1 MmLRRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIjHNlRKSzVyIE2gNE4yODJizszN NH7wV|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4PSd-MUi2PFAzPzV:L3G+
PC43-10 NXvEXXB6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHfGNphKSzVyIE2gNE4yOzhizszN M{H6d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkiwNlc2Lz5zOE[4NFI4PTxxYU6=
IGROV1 Mkm1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1W2cmlEPTBiPTCwMlIh|ryP NEezUHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4PSd-MUi2PFAzPzV:L3G+
D4 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFXDNphKSzVyIE2gNE4zPTRizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3OUc,OTh4OECyO|U9N2F-
KB NF\5UoNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHjDT4ZKSzVyIE2gNE4{OjdizszN Mn\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|UoRjF6NkiwNlc2RC:jPh?=
RT16 M1nNT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3TBSGlEPTBiPTCwMlM5QCEQvF2= M1P2fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkiwNlc2Lz5zOE[4NFI4PTxxYU6=
R2 NEjDeXJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXXEephrUUN3MDC9JFAvQDl2IN88US=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3OUc,OTh4OECyO|U9N2F-
KB MUTGeY5kfGmxbjDhd5NigQ>? NYPlZWltOzBibXnudy=> NF73S4FKSzVyIE2gNE4xOyEQvF2= NIT3SW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO3NVA{QSd-MUmzO|ExOzl:L3G+
R2 M{fLdGZ2dmO2aX;uJIF{e2G7 MkfzT4khRSByLkC5OkDPxE1? Mn;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByOEWzNlgoRjJyMEi1N|I5RC:jPh?=
R2 NXfoVJZGTnWwY4Tpc44h[XO|YYm= NX3MNZlEU2liPTCxMlU1KM7:TR?= M4LOVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEi1N|I5Lz5{MEC4OVMzQDxxYU6=
KB NYnIS|hRTnWwY4Tpc44h[XO|YYm= M4LEOmlEPTBiPTCzNEDPxE1? MkPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByOEWzNlgoRjJyMEi1N|I5RC:jPh?=
R2 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NH3OboEyOCC2bzCxOEBl[Xm| MY\JR|UxKD1iMD6wNFQ6PCEQvF2= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5OUe1O{c,OjF6N{m3OVc9N2F-
R2 MnLwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoK2PVYhcHK| MYjJR|UxKD1iMD6wNVMzKM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5OUe1O{c,OjF6N{m3OVc9N2F-
RT16 NV;vXYtPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{Pvc|k3KGi{cx?= NH\oc5NKSzVyIE2gNE4xPDJizszN M{PFe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe5O|U4Lz5{MUi3PVc2PzxxYU6=
D4 NYD2VI4ySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NH7BbJM6PiCqcoO= MXHJR|UxKD1iMD6wOkDPxE1? NELuSXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3PVc2Pyd-MkG4O|k4PTd:L3G+
KB M4TubGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIXjdZQ6PiCqcoO= NUPTS4p6UUN3MDC9JFAvODZ6IN88US=> M1Pj[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe5O|U4Lz5{MUi3PVc2PzxxYU6=
IGROV1 M1nafmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NW\id3p7QTZiaILz MmXRTWM2OCB;IECuNVAzKM7:TR?= MlrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{m3OVcoRjJzOEe5O|U4RC:jPh?=
PC43-10 NFP1fmpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3fqclk3KGi{cx?= M3PLNGlEPTBiPTCwMlE{QCEQvF2= NWTPfmlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|k4PTdpPkKxPFc6PzV5PD;hQi=>
IGROV1 M2fHfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXvtelZ5QTZiaILz Mlu0TWM2OCB;IECuNkDPxE1? MlTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{m3OVcoRjJzOEe5O|U4RC:jPh?=
D4 NETSXmFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M17n[lk3KGi{cx?= NI\SRWFKSzVyIE2gNE4zPTRizszN NX7hPI45RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|k4PTdpPkKxPFc6PzV5PD;hQi=>
KB NHPy[mRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGXRUoY6PiCqcoO= MV\JR|UxKD1iMD6zNlch|ryP MmrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{m3OVcoRjJzOEe5O|U4RC:jPh?=
RT16 M{\oeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M320XFk3KGi{cx?= MlfyTWM2OCB;IECuN|g5KM7:TR?= MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{m3OVcoRjJzOEe5O|U4RC:jPh?=
R2 MkftRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlfmPVYhcHK| NYnwOFZtUUN3MDC9JFAvQDl2IN88US=> M4XqbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe5O|U4Lz5{MUi3PVc2PzxxYU6=
R2(VC) NX:xVotSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmTWPVYhcHK| MYjJR|UxKD1iMD65O|Qh|ryP M4jMW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe5O|U4Lz5{MUi3PVc2PzxxYU6=
R2 NEf5WGFHfW6ldHnvckBie3OjeR?= NET5OoxMcSB;IECuNFk1KM7:TR?= M13DVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkSzOVI5Lz5{MkK0N|UzQDxxYU6=
R2 M3njXWZ2dmO2aX;uJIF{e2G7 NF\YT45McSB;IEKuOVQh|ryP M3PCOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkSzOVI5Lz5{MkK0N|UzQDxxYU6=
R2 MnHJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjMNG8xQTZiaILz NGPsS5BKSzVyIE2gNE4xOTN{IN88US=> Mlf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUG5OFIoRjJ2MUGxPVQzRC:jPh?=
RT16 NIXlXJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3;Pelk3KGi{cx?= M1uydGlEPTBiPTCwMlA1OiEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzMUm0Nkc,OjRzMUG5OFI9N2F-
D4 Moj2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1raXVk3KGi{cx?= MVzJR|UxKD1iMD6wOkDPxE1? M1fwSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUGxPVQzLz5{NEGxNVk1OjxxYU6=
KB MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjnPVYhcHK| NHTCW4JKSzVyIE2gNE4xPjhizszN NEPPfIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxNVk1Oid-MkSxNVE6PDJ:L3G+
PC43-10 M3TpW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnHEPVYhcHK| NIXL[YVKSzVyIE2gNE4yOzhizszN M1XYR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUGxPVQzLz5{NEGxNVk1OjxxYU6=
D4 NHG0eIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXy5OkBpenN? NXfkUlNRUUN3MDC9JFAvOjV2IN88US=> NIewU|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxNVk1Oid-MkSxNVE6PDJ:L3G+
KB NYfi[lZtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjvPVYhcHK| NWrMSnA1UUN3MDC9JFAvOzJ5IN88US=> NX61UXVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNVE6PDJpPkK0NVEyQTR{PD;hQi=>
RT16 NYf2dJNET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1S1VFk3KGi{cx?= M3H6d2lEPTBiPTCwMlM5QCEQvF2= MljwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUG5OFIoRjJ2MUGxPVQzRC:jPh?=
MTXRII-OuaR2-4 Mnu0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXZPVYhcHK| NYnxcYl6UUN3MDC9JFAvQDl2IN88US=> M3;zUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUGxPVQzLz5{NEGxNVk1OjxxYU6=
R2(VC) M1yxOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnv3PVYhcHK| NWnXNGZLUUN3MDC9JFAvQTd2IN88US=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzMUm0Nkc,OjRzMUG5OFI9N2F-
KB M4LtZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlnUPVYhcHK| MlLDTWM2OCB;IECuNFA6QTRizszN NEj6TGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK1OlQyOCd-MkSyOVY1OTB:L3G+
KB MUHGeY5kfGmxbjDhd5NigQ>? NW[3U4w2OzBibXnudy=> M2rWZ2lEPTBiPTCwMlAyOTd2IN88US=> MnfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NU[0NVAoRjJ2MkW2OFExRC:jPh?=
RT16 NWnKVYg1S3m2b4TvfIlkcXS7IHHzd4F6 MoK0PVYhcHK| MorrTWM2OCB;IECuNFE5OiEQvF2= M13vWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkW2OFExLz5{NEK1OlQyODxxYU6=
R2 M{PYUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGTvZoI6PiCqcoO= NYLMRlFOUUN3MDC9JFAvODJ{MzFOwG0> M4i0XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkW2OFExLz5{NEK1OlQyODxxYU6=
PC43-10 MnvBR5l1d3SxeHnjbZR6KGG|c3H5 Ml3mPVYhcHK| MXPJR|UxKD1iMD6wN|A3KM7:TR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ3NkSxNEc,OjR{NU[0NVA9N2F-
KB NUL4cohiS3m2b4TvfIlkcXS7IHHzd4F6 NX3WWHdZQTZiaILz NVvYbHppUUN3MDC9JFAvPjlizszN MnfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NU[0NVAoRjJ2MkW2OFExRC:jPh?=
R2/PCFT4 Mn;nSpVv[3Srb36gZZN{[Xl? M{nVUlk3KGi{cx?= MYLJR|UxKD1iMD6wNVMzKM7:TR?= M1rF[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkO0NVI5Lz5{NUKzOFEzQDxxYU6=
RT16 M3TVeGZ2dmO2aX;uJIF{e2G7 NGXHcZU6PiCqcoO= MUHJR|UxKD1iMD6wOFIh|ryP MkTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{SxNlgoRjJ3MkO0NVI5RC:jPh?=
D4 MnnXSpVv[3Srb36gZZN{[Xl? M{n0UVk3KGi{cx?= MlHETWM2OCB;IECuNFYh|ryP MknXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{SxNlgoRjJ3MkO0NVI5RC:jPh?=
KB Ml;1R5l1d3SxeHnjbZR6KGG|c3H5 MVi5OkBpenN? NX;wTFZpUUN3MDC9JFAvODZ6IN88US=> MoDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{SxNlgoRjJ3MkO0NVI5RC:jPh?=
PC43-10 MUXGeY5kfGmxbjDhd5NigQ>? M2LiXFk3KGi{cx?= M3XOcmlEPTBiPTCwMlE{QCEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ|NEGyPEc,OjV{M{SxNlg9N2F-
D4 M2TkWmZ2dmO2aX;uJIF{e2G7 NYL3XmFEQTZiaILz Mk\FTWM2OCB;IECuNlU1KM7:TR?= NHnHTII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzOFEzQCd-MkWyN|QyOjh:L3G+
KB Mk\JR5l1d3SxeHnjbZR6KGG|c3H5 NY\IZYNGQTZiaILz M1\S[WlEPTBiPTCwMlMzPyEQvF2= NH7Ic5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzOFEzQCd-MkWyN|QyOjh:L3G+
RT16 NHHmPJlHfW6ldHnvckBie3OjeR?= MUO5OkBpenN? M1q2RmlEPTBiPTCwMlM5QCEQvF2= NGHM[JM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzOFEzQCd-MkWyN|QyOjh:L3G+
R2 NUfBU|lKS3m2b4TvfIlkcXS7IHHzd4F6 NUKxOoFVQTZiaILz M{LsXWlEPTBiPTCwMlg6PCEQvF2= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ|NEGyPEc,OjV{M{SxNlg9N2F-
R2 NILjPXFEgXSxdH;4bYNqfHliYYPzZZk> NF7NdYw6PiCqcoO= M1jGcmlEPTBiPTCwMlk4PCEQvF2= NHixeFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzOFEzQCd-MkWyN|QyOjh:L3G+
KB MULGeY5kfGmxbjDhd5NigQ>? NI\2SYoyKGi{ M{fG[2lEPTBiPTCwMlAyOTd2IN88US=> MlPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MEK2N|coRjJ3NkCyOlM4RC:jPh?=
R2/PCFT4 M{LWSmZ2dmO2aX;uJIF{e2G7 NWP0RZptQTZiaILz MnriTWM2OCB;IECuNFE{OiEQvF2= MmjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MEK2N|coRjJ3NkCyOlM4RC:jPh?=
RT16 MnvrSpVv[3Srb36gZZN{[Xl? MmnYPVYhcHK| NYruVFY5UUN3MDC9JFAvODR{IN88US=> NH;jdGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[wNlY{Pyd-MkW2NFI3Ozd:L3G+
R2 NEThWVFEgXSxdH;4bYNqfHliYYPzZZk> NGOyXm46PiCqcoO= NHrVcWpKSzVyIE2gNE4xPDJizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyMk[zO{c,OjV4MEK2N|c9N2F-
KB NHXh[IdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWW5OkBpenN? NEi4PY5KSzVyIE2gNE4xPjhizszN M{ntN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkCyOlM4Lz5{NU[wNlY{PzxxYU6=
PC43-10 Mn\NSpVv[3Srb36gZZN{[Xl? NH\pWZM6PiCqcoO= NUXUVFdXUUN3MDC9JFAvOTN6IN88US=> MlW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MEK2N|coRjJ3NkCyOlM4RC:jPh?=
R2(VC) M3LRXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3L5eVk3KGi{cx?= MmXjTWM2OCB;IECuPVc1KM7:TR?= NWPUT3hHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NFI3OzdpPkK1OlAzPjN5PD;hQi=>
KB NWmxTJlSS3m2b4TvfIlkcXS7IHHzd4F6 NUjZ[pl{PzJiaILz MnHwTWM2OCB;IECuNFch|ryP NVv6Z2ZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2Olg1QTRpPkK1OlY5PDl2PD;hQi=>
A549 NVvRS|ZDS3m2b4TvfIlkcXS7IHHzd4F6 MnTzO|IhcHK| MYTJR|UxKD1iMD6wPEDPxE1? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4OES5OEc,OjV4Nki0PVQ9N2F-
HepG2 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NGfI[Y84OiCqcoO= M{j6VGlEPTBiPTCxMlI3KM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4OES5OEc,OjV4Nki0PVQ9N2F-
R2/PCFT4 M4XCSmZ2dmO2aX;uJIF{e2G7 NFzvSGMzKG2rboO= MkT6T{A:KDBwMES0JO69VQ>? NYDSPWNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVc{OzFpPkK2N|E4OzNzPD;hQi=>
R2/PCFT4 NG\CNlZHfW6ldHnvckBie3OjeR?= MoT0NkBucW6| NHrV[YxMKD1iMD6yO{DPxE1? MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MUezN|EoRjJ4M{G3N|MyRC:jPh?=
KB NYTsZpJwSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3O5bFczKGi{cx?= M3nlVmlEPTBiPTCwMlA4KM7:TR?= M3fhWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVUzLz5{N{CxO|U2OjxxYU6=
SW620 Mn;YRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MV[3NkBpenN? MnrkTWM2OCB;IECuNFgh|ryP NXey[|VlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PTJpPkK3NFE4PTV{PD;hQi=>
A549 NVLucWhISW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1zSOlczKGi{cx?= M{n5fmlEPTBiPTCxMlI3KM7:TR?= NIXESIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U2Oid-MkewNVc2PTJ:L3G+
KB MU\GeY5kfGmxbjDhd5NigQ>? M3HG[lczKGi{cx?= M1r2TmlEPTBiPTCwMlA4KM7:TR?= NXXEdmZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4N|AxOzJpPkK4PFMxODN{PD;hQi=>
SW620 NGrKWGVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXW3NkBpenN? MofzTWM2OCB;IECuNFkh|ryP Mk\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6M{CwN|IoRjJ6OEOwNFMzRC:jPh?=
MCF7 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFvsT4Y4OiCqcoO= NILXT2JKSzVyIE2gNE43PSEQvF2= MomwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6M{CwN|IoRjJ6OEOwNFMzRC:jPh?=
R2/PCFT4 NE\YPJVHfW6ldHnvckBie3OjeR?= MmDyPVYhcHK| MVvJR|UxKD1iMD6wNVMzKM7:TR?= M3K5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK1OFQ{Lz5{OUSyOVQ1OzxxYU6=
RT16 M2W2cWZ2dmO2aX;uJIF{e2G7 M33FbFk3KGi{cx?= NHO5O2tKSzVyIE2gNE4xPDJizszN NYDlTZhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlU1PDNpPkK5OFI2PDR|PD;hQi=>
D4 NGnzRnFHfW6ldHnvckBie3OjeR?= MmLMPVYhcHK| MlfGTWM2OCB;IECuNFYh|ryP MmLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkW0OFMoRjJ7NEK1OFQ{RC:jPh?=
KB NHXPbmZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYLLVmNSQTZiaILz M3\ZcmlEPTBiPTCwMlA3QCEQvF2= NXP0cYlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlU1PDNpPkK5OFI2PDR|PD;hQi=>
PC43-10 MkXuSpVv[3Srb36gZZN{[Xl? MVu5OkBpenN? MXvJR|UxKD1iMD6xN|gh|ryP NVnJRWI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlU1PDNpPkK5OFI2PDR|PD;hQi=>
D4 MUHGeY5kfGmxbjDhd5NigQ>? MkHFPVYhcHK| M3TtWmlEPTBiPTCwMlI2PCEQvF2= M1\LflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK1OFQ{Lz5{OUSyOVQ1OzxxYU6=
R2/PCFT4 NXfnWGtuTnWwY4Tpc44h[XO|YYm= MmGwNkBucW6| NWHocZJyU2liPTCwMlI2QSEQvF2= NV3hW5lqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlU1PDNpPkK5OFI2PDR|PD;hQi=>
KB NHP1ZW1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NH\QdlM6PiCqcoO= MnLaTWM2OCB;IECuN|I4KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{NUS0N{c,Ojl2MkW0OFM9N2F-
R2 MnnZR5l1d3SxeHnjbZR6KGG|c3H5 MmrGPVYhcHK| NHTCclBKSzVyIE2gNE45PDlizszN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{NUS0N{c,Ojl2MkW0OFM9N2F-
RT16 NHmxOYVHfW6ldHnvckBie3OjeR?= MnniPVYhcHK| NEnofmlKSzVyIE2gNE45QTRizszN NWrld21YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlU1PDNpPkK5OFI2PDR|PD;hQi=>
R2(VC) M2\Zdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIf4Uok6PiCqcoO= NIr6N4lKSzVyIE2gNE46PzRizszN NEHqTm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyOVQ1Oyd-Mkm0NlU1PDN:L3G+
A549 MnTKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3\JSFI1KGi{cx?= M1WwTGlEPTBiPTCzMlMyKM7:TR?= NH60V|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUiwO|M{Oid-Mkm4NFc{OzJ:L3G+
MDA-MB-231 NG\PVpNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3nmc|I1KGi{cx?= Mnj1TWM2OCB;IEOuPFUh|ryP MkTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6MEezN|IoRjJ7OEC3N|MzRC:jPh?=
OVCAR3 M1L6N2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnK5NlQhcHK| Mnr4TWM2OCB;IE[uPUDPxE1? Mn25QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6MEezN|IoRjJ7OEC3N|MzRC:jPh?=
SGC7901 MnzXRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVuyOEBpenN? MmHsTWM2OCB;IEmuNFgh|ryP MkDzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6MEezN|IoRjJ7OEC3N|MzRC:jPh?=
KB M3vQS2Z2dmO2aX;uJIF{e2G7 MluwNUB2VQ>? MXKyOEBpenN? NFy4WWlKdmS3Y4Tpc44hd2ZiYYDvdJRwfGmlIHHjeIl3cXS7IHnuJIh2dWGwIFvCJINmdGy|IHH0JFEhfU1iYX\0[ZIhOjRiaILz NGfVRnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4PSd-MUi2PFAzPzV:L3G+
R2 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGLSNmxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JINpcW6nc3WgbIFue3SncjDSNkBk\WyuczDlfJBz\XO|aX7nJIh2dWGwIGDDSnQh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iaX6geIhmKHC{ZYPlcoNmKG:oIEGwJJVOKHSqeX3p[Ilv\SCjbnSgN|IxKHWPIFHJR2E> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5OUe1O{c,OjF6N{m3OVc9N2F-
R2 NUjSbpYzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml\ORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDjbIlv\XOnIHjhcZN1\XJiUkKgZ4VtdHNiZYjwdoV{e2mwZzDoeY1idiCSQ1\UJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGmwIITo[UBxemW|ZX7j[UBw\iB4MDD1UUBi\GWwb4PpcoU> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5OUe1O{c,OjF6N{m3OVc9N2F-
R2 Mmm0SpVv[3Srb36gZZN{[Xl? NX60c2hoUW6qaXLpeIlwdiCxZjDHRXJHXGG|ZTDpckBkcGmwZYPlJIhidXO2ZYKgVlIh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDQR2ZVKGG|c3Xzd4VlKGG|IHnuZ49zeG:{YYTpc44hd2ZiW{G0R31odHmlaX7lJIlvfG9iW{G0R31nd3KveXygS2FTKGmwIITo[UBxemW|ZX7j[UBw\iB2IIXNJIF7[XOncnnu[S=> NIryfXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3PVc2Pyd-MkG4O|k4PTd:L3G+
R2 MlH5SpVv[3Srb36gZZN{[Xl? M{\QNVExKHWP NVTzd3cyUW6qaXLpeIlwdiCxZjDoeY1idiCSQ1\UMY1m\GmjdHXkJHs{UF2PVGigeZB1[WunIHXjeI9xcWOjbHz5JIV5eHKnc4Pl[EBqdiClaHnu[ZNmKGijbYP0[ZIhWjJiY3XscJMh[XRiMUCgeW0h[XRicFigOU42KHSxIEeuNi=> M1LiW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe5O|U4Lz5{MUi3PVc2PzxxYU6=
PC43-10 MULGeY5kfGmxbjDhd5NigQ>? NFuzTo4yOCC3TR?= M2H0SlIhdWmwcx?= M2HhOGlvcGmkaYTpc44hd2ZiaIXtZY4hWk[FLX3l[IlifGWmIGuzTH1OXFhidYD0ZYtmKGmwIHPobY5me2ViaHHtd5RmeiCSQ{SzMVExKGOnbHzzJIF1KDFyIIXNJIFnfGW{IEKgcYlveyC{ZXzheIl3\SC2bzDjc451em:u MoruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{m3OVcoRjJzOEe5O|U4RC:jPh?=
KB MWfGeY5kfGmxbjDhd5NigQ>? M2Pkb|EhfU1? M2K4TlQ5KGi{cx?= MoD2TY5pcWKrdHnvckBw\iCDSVPBVmZV[XOnIHnuJIh2dWGwIFvCJINmdGy|IHHzd4V{e2WmIHHzJJBpd3OyaH;yfYxifGWmIFHNVGsh[XRiMTD1UUBi\nSncjC0PEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NYTZXIUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOVY1OTBpPkK0NlU3PDFyPD;hQi=>
KB NVfOfHJUS3m2b4TvfIlkcXS7IHHzd4F6 MX[5OkBpenN? NV;aSHd2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh\XiycnXzd4lv\yCqdX3hckBTTkNxRmLhcJBp[S:SQ1\UJIFnfGW{IEm2JIhzeyCkeTDD[YxtXGm2cnWtRox2\SCobIXvdoV{[2WwY3WgZZN{[XliaX6gdJJme2WwY3Wgc4Yh[WSnbn;zbY5mN0GLQ1GveIh6dWmmaX7l MmOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NU[0NVAoRjJ2MkW2OFExRC:jPh?=
KB NFjKdYRE\WyuIHP5Z4xmKGG{cnXzeEBie3OjeR?= NH;XeVkyKHWP MYe0PEBpenN? NGrQXmhE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBMSiClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFxR{CgdIhie2ViYYSgNUB2VSCjZoTldkA1QCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcI94KGO7dH;t[ZRzgSC{ZXzheIl3\SC2bzDjc451em:u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ3NkSxNEc,OjR{NU[0NVA9N2F-
KB MVzGeY5kfGmxbjDhd5NigQ>? NX;uSGlXPDhiaILz MWTJcohq[mm2aX;uJI9nKEGLQ1HSSnRie2ViaX6gbJVu[W5iS1KgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKG:oIGrNVEBi\nSncjC0PEBpenNiYomgTHBNSyCjbnHsfZNqew>? NYDIOYxxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOVY1OTBpPkK0NlU3PDFyPD;hQi=>
R2/PCFT4 Mn3QSpVv[3Srb36gZZN{[Xl? NGX3VpgxNjVidV2= MmrmOUBucW6| Ml7rRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDQR2ZVKGW6cILld5Nm\CCrbjDDbIlv\XOnIHjhcZN1\XJiUkKvVGNHXDRiY3XscJMh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBlenWpIHzleoVtKGG2IECuOUB2VSCjdDCzO{Bl\WeFIHH0JJBJKDVwNTDt[YF{fXKnZDDveoVzKDVibXnudy=> NH[1dFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxO|M{OSd-Mk[zNVc{OzF:L3G+
TC32 M1P2bpFJXFNiYYPzZZk> NUDlc215eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGTDN|Ih[2WubIO= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
A673 NVLQ[WtneUiWUzDhd5NigQ>? NX7pO5h2eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSTZ5MzDj[Yxteyl? MoLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC M{LDW5FJXFNiYYPzZZk> MXPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= MlXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1 Mn75dWhVWyCjc4PhfS=> MUPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?= NXfORopLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 MV3xTHRUKGG|c3H5 MojmdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR|IHPlcIx{ MorQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MlfydWhVWyCjc4PhfS=> NULL[4s6eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
TC32 MVjxTHRUKGG|c3H5 M37Y[ZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHREOzJiY3XscJM> M2LrSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
IGROV1 MkjxSpVv[3Srb36gZZN{[Xl? NFvpUZdG\m[nY4Sgc44hXFNicILveIVqdiCneIDy[ZN{cW:wIHnuJIh2dWGwIFnHVm9XOSClZXzsd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= Mn;DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{W1OFEoRjNyMEO1OVQyRC:jPh?=
IGROV1 MYjGeY5kfGmxbjDhd5NigQ>? M2rGWWVn\mWldDDvckBFUE[UIIDyc5RmcW5iZYjwdoV{e2mxbjDpckBpfW2jbjDJS3JQXjFiY3XscJMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NX\4RWt7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwN|U2PDFpPkOwNFM2PTRzPD;hQi=>
IGROV1 MYrGeY5kfGmxbjDhd5NigQ>? MWLF[oZm[3Rib36gTHNRQTBicILveIVqdiCneIDy[ZN{cW:wIHnuJIh2dWGwIFnHVm9XOSClZXzsd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB|NUW0NUc,OzByM{W1OFE9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / Cyclin D / Cyclin E / p-Histone H3 / Histone H3 / Cyclin B1 / p-Cdc2 / Cdc2 ; 

PubMed: 22237209     


Protein alterations in the response to DNA damage, cell cycle progression, and cell death were detected in (c) UDG−/− cells and (d) UDG+/+ cells treated with pemetrexed. Cells were collected at 6 and 24 h after pemetrexed treatment. Results are representative of two independent experiments.

Topo IIα / Topo I / γH2AX / Cleaved PARP / Survivin; 

PubMed: 22237209     


Protein alterations involved in regulation of apoptotic cell death were detected in (c) UDG−/− cells and (d) UDG+/+ cells treated with pemetrexed. Cells were collected at 6 and 24 h after pemetrexed treatment. Results are representative of two independent experiments.

AKT / p-AKT / GSK3β / p-GSK3β ; 

PubMed: 24847863     


Akt activation in a time course dependent manner. Human lung adenocarcinoma A549 cells were treated without or with 1 µM pemetrexed for 0, 4, 8, 12, 24, and 48 h, and then cell lysates were isolated. After treatment, the levels of total Akt, phosphorylated Akt, total GSK3β, and phosphorylated GSK3β were examined by Western blot analysis. β-Actin was used as an internal loading control. 

EGFR / p-EGFR ; 

PubMed: 30953548     


After treatment with incremental exposure time of pemetrexed. The total and phosphorylated EGFR, AKT, and MAPK proteins in PC-9 cells were detected by Western blot. GAPDH served as the loading control. 

22237209 24847863 30953548
Immunofluorescence
p-AKT; 

PubMed: 24847863     


A549 cells were treated with 0, 0.1, 0.3, and 1 µM pemetrexed for 48 h. After treatment, the subcellular distribution of p-AktS473 was detected by confocal microscopy after immunostaining with anti-phospho-AktS473 and Rhodamine-conjugated secondary antibody. Hoechst 33342 was used to counter stain nuclei, and the images were overlaid to determine the Akt localization within the cell.

24847863
Growth inhibition assay
Cell viability; 

PubMed: 28719077     


Effects of metformin and (or) pemetrexed on the proliferation of human NSCLC cell lines. (A) Antiproliferative effects of metformin on NSCLC cells. (B) Effects of pemetrexed on the proliferation of the three tested cell lines. (C) Metformin in combination with pemetrexed inhibits the proliferation of the tested cells. (D–F) Effects of metformin and (or) pemetrexed on the proliferation of A549(D), HCC827(E), and H1975(F) cell lines. (G–I) Strengthening antiproliferative effects of metformin in combination with pemetrexed on A549(G), HCC827(H), H1975(I) cell lines,*P < 0.05. Metf represents metformin; Pem represents pemetrexed.

28719077
In vivo In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD). [3]

Protocol

Kinase Assay:[1]
- Collapse

Enzyme Assays and Methods. :

TS activity is assayed using a spectrophotometric method, which involved monitoring the increase in absorbance at 340 nm resulting from formation of the product, 7,8-dihydrofolate. The assay buffer contains 50 mM N-tris[hydroxymethyljmethyl-2-aminoethanesulfonic acid, 25 mM MgC12, 6.5 mM formaldehyde, 1 mM EDTA, and 75 mM 2-mercaptoethanol, pH 7.4. The concentrations of deoxyuridylate monophosphate, 6R-MTHF, and hIS are 100 μM, 30μM and 30 nM (1.7 milliunits/mL), respectively. At the 6R-MTHF concentration, an uninhibited reaction and six concentrations of inhibitor are assayed. Ki app values are determined by fitting the data to the Morrison equation using nonlinear regression analysis with the aid of the program ENZFITTER. Ki values are calculated using the equation: Ki app= Ki(1 + [S]/Km), where [S] is equal to 30 μM and Km is equal to 3 μM. DHFR activity is assayed spectrophotometrically by monitoring the dis appearance of the substrates NADPH and 7,8-dihydrofolate at 340 nm. The reaction takes place at 25°C in 0.5 mL of 50 mM potassium phosphate buffer, which contains 150 mM KC1 and 10 nM 2-mercaptoethanol, pH 7.5, and 14 nM (0.34 milliunitlmL) DHFR. The NADPH concentration is 10 μM and 7,8-dihydrofolate is varied at 5, 10, or 15 μM. At each 7,8-dihydrofolate concentration, an uninhibited reaction and seven concentrations of inhibitor are assayed. The ENZFITI'ER microcomputer program is used to obtain Ki app values by fitting the data to the Morrison equation by nonlinear regression analysis. Ki app= Ki(1 + [S]/Km), where [S] is equal to the concentration of 7,8-dihydrofolate used and Km of 7,8-dihydrofolate is equal to 0.15 μM. GARFT activity is assayed spectrophotometrically by monitoring the increase of absorbance resulting from formation of the product 5,8-dideazafolate at 295 nm. The reaction solvent contains 75 mM HEPES, 20% glycerol, and 50 mM a-thioglygerol, pH 7.5, at 25°C. The concentrations of substrates and enzyme used are 10 μM α,β-glycinamide ribonucleotide, 0-10 μM 10-formyl-5,8-dideazafolic acid, and 10 nM (1.9 milliunits/mL) GARFT. Ki values are calculated using the Enzyme Mechanism program of the Beckman DU640 spectrophotometer, which uses nonlinear regression analysis to fit data to the Michaelis-Menten equation for competitive inhibition.
Cell Research:[1]
- Collapse
  • Cell lines: CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells.
  • Concentrations: 0-30 μM
  • Incubation Time: 72 hours
  • Method: Dose-response curves are generated to determine the concentration required for 50% inhibition of growth (IC50). Pemetrexed disodium is dissolved initially in DMSO at a concentration of 4 mg/mL and further diluted with cell culture medium to the desired concentration. CCRF-CEM leukemia cells in complete medium are added to 24-well Cluster plates in a total volume of 2.0 mL. Pemetrexed disodium at various concentrations are added to duplicate wells so that the final volume of DMSO is 0.5%. The plates are incubated for 72 hour at 37 °C in an atmosphere of 5% CO2 in air. At the end of the incubation, cell numbers are determined on a ZBI Coulter counter. For several studies, IC50s are determined for each compound in the presence of either 300 μM AICA, 5 μM thymidine, 100 μM hypoxanthine, or combination of 5 μM hymidine plus 100 μM hypoxanthine. For adherent tumor cells, a modification of the original MTT colorimetric assay is used to measure cell cytotoxicity. The human tumor cells are seeded in 100 μL assay medium/well in 96-well flat-bottomed tissue culture plates. The assay medium contains folic acid-free RPMI 1640 supplemented with 10% FCS and either 2 nM folinic acid or 2.3 μM folic acid as the sole folate source. Well 1A is left blank. Stock solutions of antifolates are prepared in Dulbecco's PBS at 1 mg/mL, and a series of 2-fold dilutions are subsequently made in PBS. Ten-μL aliquots of each concentration are added to triplicate wells. Plates are incubated for 72 hours at 37 °C in a humidified atmosphere of 5% CO2-in-air. MTT is dissolved in PBS at 5 mg/mL, 10 μL of stock MTF solution are added to each well of an assay, and the plates are incubated at 37 °C for 2 additional hours. Following incubation, 100 μL of DMSO are added to each well. After thorough formazan solubilization, the plates are read on a Dynatech MR600 reader, using a test wavelength of 570 nm and a reference wavelength of 630 nm. The IC50 is determined as the concentration of drug required to inhibit cell growth by 50% compared to an untreated controls.
    (Only for Reference)
Animal Research:[3]
- Collapse
  • Animal Models: EMT-6 mammary carcinoma, the human HCT 116 colon carcinoma, and the human H460 non-small cell lung carcinoma are injected s.c. into the nude mice.
  • Dosages: 100 mg/kg or 150 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 94 mg/mL (199.41 mM)
DMSO Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 471.37
Formula

C20H19N5Na2O6

CAS No. 150399-23-8
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04173338 Recruiting Drug: Cabozantinib|Drug: Pemetrexed Non Small Cell Lung Cancer|Non-squamous Non-small-cell Lung Cancer|Urothelial Carcinoma|Malignant Mesothelioma Augusta University January 23 2020 Phase 1
NCT03656549 Recruiting Drug: Pemetrexed Non Small Cell Lung Cancer|Mesothelioma Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development February 1 2019 Phase 2
NCT03655821 Recruiting Drug: Pemetrexed Non Small Cell Lung Cancer|Mesothelioma Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development February 1 2019 Phase 4
NCT03526900 Active not recruiting Drug: Atezolizumab Non-small Cell Lung Cancer Stage IV Spanish Lung Cancer Group July 7 2018 Phase 2
NCT03537833 Recruiting Other: pemetrexed-related hematological toxicity Patients With Non-small Cell Lung Cancer (NSCLC) and Pleural Mesothelioma and Treated With a Pemetrexed-based Chemotherapy CHU de Reims May 2 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

DHFR Signaling Pathway Map

Related DHFR Products

Tags: buy Pemetrexed (LY-231514) disodium | Pemetrexed (LY-231514) disodium supplier | purchase Pemetrexed (LY-231514) disodium | Pemetrexed (LY-231514) disodium cost | Pemetrexed (LY-231514) disodium manufacturer | order Pemetrexed (LY-231514) disodium | Pemetrexed (LY-231514) disodium distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID