Luminespib (NVP-AUY922)

Name: Luminespib (NVP-AUY922)
Brand: Selleck Chemicals
SKU: S1069
Rating: 5 (56 reviews)

For research use only. Not for use in humans.

Catalog No.S1069 Synonyms: AUY-922

56 publications

Luminespib (NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Selleck's Luminespib (NVP-AUY922) has been cited by 56 publications

Cancer Cell, 2019, 35(5):752-766

PubMed: 31085176 ( click the link to review the publication )

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062 ( click the link to review the publication )

Hepatology, 2019, 69(2):573-586

PubMed: 29356025 ( click the link to review the publication )

Nat Commun, 2019, 10(1):402

PubMed: 30679438 ( click the link to review the publication )

J Neurosci, 2019, 39(17):3332-3344

PubMed: 30696728 ( click the link to review the publication )

Cells, 2019, 8(8)

PubMed: 31370342 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(11):2097-2110

PubMed: 31395684 ( click the link to review the publication )

ACS Chem Neurosci, 2019, 10(6):2890-2902

PubMed: 31017387 ( click the link to review the publication )

Front Endocrinol (Lausanne), 2019, 10:487

PubMed: 31379752 ( click the link to review the publication )

BMC Cancer, 2019, 19(1):102

PubMed: 30678647 ( click the link to review the publication )

Clin Exp Med, 2019, 10.1007/s10238-019-00587-2

PubMed: 31650359 ( click the link to review the publication )

Transl Lung Cancer Res, 2019, 8(4):340-351

PubMed: 31555510 ( click the link to review the publication )

Autophagy, 2018, 14(6):958-971

PubMed: 29561705 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(24):6548-6555

PubMed: 30154228 ( click the link to review the publication )

Mol Syst Biol, 2018, 14(3):e7858

PubMed: 29507054 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(3):1792-1804

PubMed: 29363851 ( click the link to review the publication )

BMB Rep, 2018, 51(12):660-665

PubMed: 30591093 ( click the link to review the publication )

Cancer Lett, 2017, 411:19-26

PubMed: 28987383 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2017, 80(4):673-684

PubMed: 28779264 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 487(2):313-319

PubMed: 28412368 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:2219-2226

PubMed: 28458565 ( click the link to review the publication )

Sci Rep, 2017, 7(1):201

PubMed: 28298630 ( click the link to review the publication )

Oncotarget, 2017, 8(35):58771-58780

PubMed: 28938595 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )
J Biol Chem, 2016, 291(19):10332-46

PubMed: 26957545 ( click the link to review the publication )

Horm Cancer, 2016, 7(2):114-26

PubMed: 26858237 ( click the link to review the publication )

PeerJ, 2016, 4:e1683

PubMed: 26893968 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Oncotarget, 2016, 7(31):49597-49610

PubMed: 27391062 ( click the link to review the publication )

Immun Inflamm Dis, 2016, 4(4):463-473

PubMed: 27980780 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2015, 309(12):L1410-9

PubMed: 26498249 ( click the link to review the publication )

Int J Biol Sci, 2015, 11(8):923-34

PubMed: 26157347 ( click the link to review the publication )

Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909 ( click the link to review the publication )

Oncol Lett, 2015, 10(2):941-945

PubMed: 26622600 ( click the link to review the publication )

Oncotarget, 2015, 6(31):31792-804

PubMed: 26397139 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778 ( click the link to review the publication )

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

PLoS One, 2014, 9(12):e114506

PubMed: 25503774 ( click the link to review the publication )

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175 ( click the link to review the publication )

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685 ( click the link to review the publication )
J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

J Proteome Res, 2013, 12(8):3697-706

PubMed: 23763277 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418 ( click the link to review the publication )

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346 ( click the link to review the publication )

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466 ( click the link to review the publication )

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed: ( click the link to review the publication )

Mol Cancer, 2011, 10:125

PubMed: 21962244 ( click the link to review the publication )

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	NIHQWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWfp[\|FqUUN3ME2wMlAxODF{NTFOwG0>	M{TYd3NCVkeHUh?=
MV-4-11	NWDYR29tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnCfXhKSzVyPUCuNFAxPTV6IN88US=>	MVnTRW5ITVJ?
NALM-6	M{C4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHXnbHFKSzVyPUCuNFAxQDR{IN88US=>	NXHWPJR1W0GQR1XS
HOS	NHLmdJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlO3TWM2OD1yLkCwNVM5KM7:TR?=	NH3Cd4NUSU6JRWK=
HT-144	MmTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;HNpFzUUN3ME2wMlAxOTV3IN88US=>	MYjTRW5ITVJ?
SW1710	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjq[XJqUUN3ME2wMlAxOTh4IN88US=>	MkCzV2FPT0WU
TE-8	M2nwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnzWHZKSzVyPUCuNFAzOzdizszN	Mmj0V2FPT0WU
ES1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYG3RXBOUUN3ME2wMlAxOjZ4IN88US=>	NIHJNoxUSU6JRWK=
CCF-STTG1	NYPVdm91T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzFN\|lKSzVyPUCuNFAzQTdizszN	NEj1SmJUSU6JRWK=
PSN1	MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTBwMECzNVgh\|ryP	NV35SWtpW0GQR1XS
CAL-51	NUXMcVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFfNOFJKSzVyPUCuNFA{OjVizszN	M2Xs[3NCVkeHUh?=
MCF7	NGnncmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13oOWlEPTB;MD6wNFM{PSEQvF2=	Mo[5V2FPT0WU
SK-HEP-1	M4DacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXn0[INyUUN3ME2wMlAxOzN4IN88US=>	NGHmbJpUSU6JRWK=
LCLC-103H	M1PKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPqTpFKSzVyPUCuNFA1OyEQvF2=	NGe2c4pUSU6JRWK=
HMV-II	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2X5d2lEPTB;MD6wNFQ1QSEQvF2=	MXvTRW5ITVJ?
MES-SA	NXuzTo1HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmfWTWM2OD1yLkCwOFUzKM7:TR?=	MX7TRW5ITVJ?
SK-LMS-1	MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX[zd3Z6UUN3ME2wMlAxPDV6IN88US=>	MXnTRW5ITVJ?
639-V	NIrFS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWTJR\|UxRTBwMEC0PFUh\|ryP	NVT6ZVFNW0GQR1XS
SIG-M5	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{i1cWlEPTB;MD6wNFQ5QSEQvF2=	Mlj2V2FPT0WU
LOUCY	NF;JR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPqV5NYUUN3ME2wMlAxPTB3IN88US=>	MmTzV2FPT0WU
HSC-2	Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHEc4VkUUN3ME2wMlAxPTF6IN88US=>	M4OzeXNCVkeHUh?=
EW-13	MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;hZndKSzVyPUCuNFA2OThizszN	Mmj6V2FPT0WU
RT-112	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTBwMEC1N\|Uh\|ryP	MXTTRW5ITVJ?
NKM-1	M{[2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkXYTWM2OD1yLkCwOVQ4KM7:TR?=	NHLPVHdUSU6JRWK=
KYSE-180	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHHkWXlKSzVyPUCuNFA2QDZizszN	MYXTRW5ITVJ?
SW1783	NHHtOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\HeIFKSzVyPUCuNFA2QTFizszN	MmjOV2FPT0WU
A431	M2rv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXSTWM2OD1yLkCwOlA4KM7:TR?=	MoPqV2FPT0WU
SK-OV-3	M{XjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXPr[GVVUUN3ME2wMlAxPjNizszN	MXTTRW5ITVJ?
RPMI-7951	M1rOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTBwMEC2N\|Eh\|ryP	MkLnV2FPT0WU
Capan-2	NVvoTZBUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHzUVNKSzVyPUCuNFA3OzhizszN	MmTsV2FPT0WU
HSC-3	NGPHcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoH4TWM2OD1yLkCwOlQyKM7:TR?=	NGDpZpNUSU6JRWK=
786-0	NI\PXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYniNmtkUUN3ME2wMlAxPjZ\|IN88US=>	MYnTRW5ITVJ?
Daoy	M1zyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3qyO2lEPTB;MD6wNFY6PSEQvF2=	Mlf1V2FPT0WU
KGN	NYDENnFoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDTRYRKSzVyPUCuNFA4ODNizszN	Ml;CV2FPT0WU
EW-16	NIPqTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml3aTWM2OD1yLkCwO\|Q6KM7:TR?=	MnTlV2FPT0WU
EW-7	NFrjS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPmTWM2OD1yLkCwO\|U1KM7:TR?=	Mn7rV2FPT0WU
IGROV-1	M2HaTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Moq5TWM2OD1yLkCwPFE1KM7:TR?=	MmrYV2FPT0WU
8505C	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTBwMEC4NlEh\|ryP	MVvTRW5ITVJ?
RKO	MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwMEC4NlYh\|ryP	NVHpNm5oW0GQR1XS
GDM-1	NH6xUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTyTWM2OD1yLkCwPFQh\|ryP	NFnxbo9USU6JRWK=
IST-MEL1	M3y5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwMEC4OVIh\|ryP	MVHTRW5ITVJ?
RPMI-6666	NWTpXJhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHvvOY1KSzVyPUCuNFA5PTJizszN	M1nMWXNCVkeHUh?=
SNG-M	NXm3SmdxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX;JR\|UxRTBwMEC4OVYh\|ryP	NEXwT5NUSU6JRWK=
KS-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoPaTWM2OD1yLkCwPFU6KM7:TR?=	Mk\KV2FPT0WU
RXF393	M1HJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLod25sUUN3ME2wMlAxQDZizszN	MXXTRW5ITVJ?
CAL-12T	NYXZUZh{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2K0UmlEPTB;MD6wNFkzOiEQvF2=	MmL4V2FPT0WU
BFTC-905	M4TOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnjPTWM2OD1yLkCwPVM5KM7:TR?=	M3ThdnNCVkeHUh?=
SK-MES-1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTBwMEC5OFUh\|ryP	M33TUnNCVkeHUh?=
BB30-HNC	M4jnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LObWlEPTB;MD6wNFk2OiEQvF2=	NIDZfWFUSU6JRWK=
AN3-CA	NIf2UnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPzcI5KSzVyPUCuNFExOTdizszN	MVXTRW5ITVJ?
EFO-27	MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrKTWM2OD1yLkCxNFE4KM7:TR?=	M1f3XnNCVkeHUh?=
G-401	M3zEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XNUGlEPTB;MD6wNVAzPSEQvF2=	M3rLd3NCVkeHUh?=
BPH-1	M{fWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIq5Z5JKSzVyPUCuNFExOyEQvF2=	NFP5Nm1USU6JRWK=
NCI-H727	NWGxUmNoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVi4WGJUUUN3ME2wMlAyODNizszN	NVHjT4p1W0GQR1XS
SNU-423	MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\LUWV4UUN3ME2wMlAyODV\|IN88US=>	M4TVcXNCVkeHUh?=
KYSE-270	NWGwdFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\iPYYyUUN3ME2wMlAyODV7IN88US=>	NH\6R3ZUSU6JRWK=
AGS	Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnj1TWM2OD1yLkCxNFYyKM7:TR?=	MX;TRW5ITVJ?
NCI-H2228	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTjTWM2OD1yLkCxNFY1KM7:TR?=	NXPpPHNvW0GQR1XS
SW954	MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfQ[GpKSzVyPUCuNFExPzFizszN	M{XGWXNCVkeHUh?=
769-P	Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{ezOWlEPTB;MD6wNVA4OyEQvF2=	M2juW3NCVkeHUh?=
BB49-HNC	M2r3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwMEGwO\|ch\|ryP	MmjSV2FPT0WU
IA-LM	Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEnVbYlKSzVyPUCuNFExQDZizszN	NHfKeFVUSU6JRWK=
NB69	M1zETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTBwMEGxNFIh\|ryP	MlPIV2FPT0WU
C8166	MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvsW3FKSzVyPUCuNFEyOjlizszN	Mo\OV2FPT0WU
NCI-H1299	NIixXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHpeFVKSzVyPUCuNFEyPTRizszN	NWW0XZB4W0GQR1XS
YKG-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NELFOYdKSzVyPUCuNFEyPiEQvF2=	MnfJV2FPT0WU
PANC-03-27	NGPpfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLJTWM2OD1yLkCxNVYzKM7:TR?=	M37KXXNCVkeHUh?=
YT	M{fIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEOwS45KSzVyPUCuNFEyPzlizszN	Ml:0V2FPT0WU
CAL-85-1	M4XoSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkXNTWM2OD1yLkCxNVkzKM7:TR?=	M4\kOHNCVkeHUh?=
GT3TKB	NV;kVpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDhdGdKSzVyPUCuNFEzODJizszN	NIfQVXBUSU6JRWK=
BB65-RCC	NEnzR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTBwMEGyNFQh\|ryP	MojFV2FPT0WU
ES6	NGK2UYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2rTOWlEPTB;MD6wNVI3OSEQvF2=	NGXVS4pUSU6JRWK=
MHH-ES-1	NWHwZ4x6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYX2fGd2UUN3ME2wMlAyOjZ\|IN88US=>	MWHTRW5ITVJ?
QIMR-WIL	NHnRRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXCdmpKSzVyPUCuNFEzPjlizszN	NYrxZ4R6W0GQR1XS
SNU-C2B	NHe1PHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTBwMEGyO\|Ih\|ryP	M3f2bHNCVkeHUh?=
OCI-AML2	NXu3S\|g3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoHwTWM2OD1yLkCxNlgyKM7:TR?=	NGPINGVUSU6JRWK=
DU-145	NEW3TYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTBwMEGyPUDPxE1?	MWHTRW5ITVJ?
SW982	M33YOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFXRZpZKSzVyPUCuNFEzQTNizszN	NILqeVNUSU6JRWK=
MFH-ino	NImxc5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTBwMEGyPVMh\|ryP	NF[2bXBUSU6JRWK=
A427	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;PTWM2OD1yLkCxNlk6KM7:TR?=	MYTTRW5ITVJ?
LCLC-97TM1	M{fYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTBwMEGzJO69VQ>?	NVvyWnl3W0GQR1XS
AM-38	M1WzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPGTWM2OD1yLkCxN\|AzKM7:TR?=	NEfRT5hUSU6JRWK=
K5	Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHkZWt6UUN3ME2wMlAyOzB6IN88US=>	MWjTRW5ITVJ?
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SCC-4	NHXGc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnnlTWM2OD1yLkCyPFA6KM7:TR?=	NGHnOolUSU6JRWK=
5637	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHtZpdKSzVyPUCuNFI5OjJizszN	MnPiV2FPT0WU
EW-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1vUfGlEPTB;MD6wNlgzOiEQvF2=	Mmn6V2FPT0WU
SW962	M4f6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NI\qd3dKSzVyPUCuNFI5PTJizszN	M3zub3NCVkeHUh?=
HCE-T	NEnhcVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTBwMEK4OkDPxE1?	NGXk[XFUSU6JRWK=
NCI-H2405	NGHkNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUXE[JNtUUN3ME2wMlAzQDh5IN88US=>	NFzBUYdUSU6JRWK=
A2058	MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn[0TWM2OD1yLkCyPVI6KM7:TR?=	NHfud21USU6JRWK=
HCC2998	NV70Z41vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1T5V2lEPTB;MD6wNlk1PSEQvF2=	NX6xW4NxW0GQR1XS
ONS-76	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIrIZVBKSzVyPUCuNFI6PTRizszN	MUPTRW5ITVJ?
DBTRG-05MG	NX3teoR5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEG1ZmRKSzVyPUCuNFI6PTVizszN	NX;yXlVZW0GQR1XS
HuCCT1	Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUXJR\|UxRTBwMEK5OlEh\|ryP	Ml;rV2FPT0WU
J82	M2Laemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXOTnlUUUN3ME2wMlA{ODB5IN88US=>	NGDJVFBUSU6JRWK=
MKN28	MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfTO\|Q4UUN3ME2wMlA{ODF{IN88US=>	NXrR[GtjW0GQR1XS
SW837	NGDrb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTBwMEOwNVQh\|ryP	MUHTRW5ITVJ?
no-10	NHzHVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3W0VGlEPTB;MD6wN\|AyPiEQvF2=	NX7mXFdlW0GQR1XS
BC-3	M2j6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvrd5JKSzVyPUCuNFMxOThizszN	MXnTRW5ITVJ?
no-11	NFP6N3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHWTWM2OD1yLkCzNFQ5KM7:TR?=	MWrTRW5ITVJ?
8305C	NXr0W\|Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3sOllqUUN3ME2wMlA{ODd{IN88US=>	MXzTRW5ITVJ?
COLO-679	NXr0SHpsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnG0TWM2OD1yLkCzNVA4KM7:TR?=	NIH1WY5USU6JRWK=
CESS	NUXBbGZRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HKOGlEPTB;MD6wN\|EzKM7:TR?=	NFHNfGNUSU6JRWK=
BFTC-909	NEHCWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nwZWlEPTB;MD6wN\|EzPSEQvF2=	MmT5V2FPT0WU
MZ2-MEL	NUf5NWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDmSnJbUUN3ME2wMlA{OTd5IN88US=>	NYDPfpJiW0GQR1XS
SW872	MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\pTWM2OD1yLkCzNlE4KM7:TR?=	MXPTRW5ITVJ?
LB831-BLC	M1TwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTBwMEOyNVkh\|ryP	MmnQV2FPT0WU
SK-UT-1	NFuxZ\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnLuTWM2OD1yLkCzNlIyKM7:TR?=	MX;TRW5ITVJ?
NCI-H1734	M4TLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUHuSXpGUUN3ME2wMlA{OjNizszN	M123XnNCVkeHUh?=
OVCAR-8	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1PEcGlEPTB;MD6wN\|I5OSEQvF2=	Mnm3V2FPT0WU
NCI-H2087	MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYrJR\|UxRTBwMEOyPFkh\|ryP	MVnTRW5ITVJ?
U-87-MG	NXnmT2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLMXoZnUUN3ME2wMlA{OjlizszN	M4TrN3NCVkeHUh?=
BC-1	NWL6WG9ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3jufWlEPTB;MD6wN\|M3PyEQvF2=	NVLYWVVkW0GQR1XS
ES7	NHTzOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHW5ZoJKSzVyPUCuNFM{PzRizszN	M3H0bnNCVkeHUh?=
Daudi	MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2qyOmlEPTB;MD6wN\|M4PiEQvF2=	MnzkV2FPT0WU
RS4-11	M3vVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWPle21rUUN3ME2wMlA{Ozh\|IN88US=>	MoTkV2FPT0WU
JiyoyeP-2003	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3vwVmlEPTB;MD6wN\|M5QCEQvF2=	MUfTRW5ITVJ?
BL-70	NWnSeGJPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4nycWlEPTB;MD6wN\|M5QSEQvF2=	Mkj2V2FPT0WU
OS-RC-2	M2nQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkjrTWM2OD1yLkCzN\|k3KM7:TR?=	M1XJNnNCVkeHUh?=
SF268	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVS5WpQ6UUN3ME2wMlA{PDBzIN88US=>	NWCzWIxlW0GQR1XS
BV-173	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHZTWM2OD1yLkCzOFI3KM7:TR?=	MW\TRW5ITVJ?
DMS-273	NHLz[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXEc4ZKSzVyPUCuNFM1PzlizszN	MlzjV2FPT0WU
22RV1	NHPJb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTBwMEO1NFch\|ryP	NI\Qe2JUSU6JRWK=
ES8	M3e4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTBwMEO1N\|gh\|ryP	MkG2V2FPT0WU
KYSE-150	NYn6fXdZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7ZT45KSzVyPUCuNFM3ODhizszN	M1z5SnNCVkeHUh?=
HCC1569	MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYXPXVEzUUN3ME2wMlA{PjB6IN88US=>	NGnWUXZUSU6JRWK=
NB5	NEWw[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnj5TWM2OD1yLkCzOlE{KM7:TR?=	MnrhV2FPT0WU
G-402	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGO5PIFKSzVyPUCuNFM3OTRizszN	NVfyeGxUW0GQR1XS
NCI-H1693	M2TzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTRTWM2OD1yLkCzOlE4KM7:TR?=	Mn\hV2FPT0WU
LB2241-RCC	NEnwOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjWO3FKSzVyPUCuNFM3PDJizszN	M3rSNHNCVkeHUh?=
KP-4	Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrS[\|A6UUN3ME2wMlA{PjZ\|IN88US=>	MUDTRW5ITVJ?
ML-2	M4\lXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkOwTWM2OD1yLkCzOlcyKM7:TR?=	NWLYd5ZlW0GQR1XS
KU812	NUPHVmQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{mx[GlEPTB;MD6wN\|Y5PCEQvF2=	MlnPV2FPT0WU
LS-411N	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTBwMEO3N\|Eh\|ryP	NEO5[2xUSU6JRWK=
OAW-42	M3j1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkLkTWM2OD1yLkCzO\|Q4KM7:TR?=	NFf2VHhUSU6JRWK=
HCC38	NVfydlZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\uTGlEPTB;MD6wN\|c4OSEQvF2=	MlnuV2FPT0WU
Ca-Ski	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTBwMEO3PFQh\|ryP	M1;MdXNCVkeHUh?=
Calu-3	NUD6R4g3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13nR2lEPTB;MD6wN\|c5QSEQvF2=	NXjHd\|RyW0GQR1XS
KYSE-70	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoD5TWM2OD1yLkCzPFEzKM7:TR?=	MlnnV2FPT0WU
D-392MG	NHLwTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHKwbJNKSzVyPUCuNFM5PDJizszN	NGnEfmFUSU6JRWK=
OVCAR-4	M{TBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH61Vm9KSzVyPUCuNFM5PThizszN	NYTac2VmW0GQR1XS
Detroit562	NGHaSHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3VN5RKSzVyPUCuNFM5PzJizszN	NHTZT3lUSU6JRWK=
HEL	M3vJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTBwMEO4PVEh\|ryP	NV7zN4p6W0GQR1XS
MONO-MAC-6	Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTBwMEO4PVMh\|ryP	NXXHZ4RGW0GQR1XS
LoVo	M2foWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTBwMEO5N\|Mh\|ryP	NHr3cWFUSU6JRWK=
U-2-OS	NGLUd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnT5TWM2OD1yLkCzPVM2KM7:TR?=	NWO4RoZ7W0GQR1XS
A172	NXO5UmFrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTBwMEO5OUDPxE1?	NXmwTHJ6W0GQR1XS
OCUB-M	NWLVU2ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\KTWM2OD1yLkCzPVYyKM7:TR?=	NUH0NVg5W0GQR1XS
SW48	MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrzTWM2OD1yLkC0NFMyKM7:TR?=	Mn;oV2FPT0WU
HC-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIHtcFNKSzVyPUCuNFQxPjlizszN	MoDpV2FPT0WU
KOSC-2	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nvUmlEPTB;MD6wOFEyKM7:TR?=	NVzoRXpTW0GQR1XS
HDLM-2	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4nCNWlEPTB;MD6wOFEyPCEQvF2=	NFm1V3hUSU6JRWK=
CTV-1	MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHOxfmpKSzVyPUCuNFQyOTZizszN	MmfPV2FPT0WU
SH-4	MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\hXI5oUUN3ME2wMlA1OTRzIN88US=>	NH25U\|NUSU6JRWK=
SW756	NHeyXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWLJR\|UxRTBwMESxOVch\|ryP	NHjBW3FUSU6JRWK=
GCT	NV[3TJM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkPCTWM2OD1yLkC0NVYyKM7:TR?=	NVLydGgzW0GQR1XS
CHL-1	M2HPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX\GNWFIUUN3ME2wMlA1OTZ7IN88US=>	M4XY[3NCVkeHUh?=
LAMA-84	MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;EfXFLUUN3ME2wMlA1OTdzIN88US=>	M4XwSHNCVkeHUh?=
LS-1034	M4XS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwMESxPVEh\|ryP	NXHHcphbW0GQR1XS
NCI-H358	MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mmq4TWM2OD1yLkC0NlEzKM7:TR?=	MnjmV2FPT0WU
NB13	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUPJR\|UxRTBwMESyNlch\|ryP	MWPTRW5ITVJ?
TE-9	Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\rTWM2OD1yLkC0NlM4KM7:TR?=	NIrEeYJUSU6JRWK=
OE33	NEXnXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1nSSWlEPTB;MD6wOFI1OSEQvF2=	MWTTRW5ITVJ?
CAL-120	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHi0N\|BKSzVyPUCuNFQzPDFizszN	NYHHSJFnW0GQR1XS
DJM-1	NHuzRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHubGZQUUN3ME2wMlA1Ojd{IN88US=>	Mlm4V2FPT0WU
SK-MEL-24	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTBwMESyPFMh\|ryP	NFXnXZZUSU6JRWK=
VA-ES-BJ	M4HHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnnoTWM2OD1yLkC0NlkzKM7:TR?=	M4rocHNCVkeHUh?=
MMAC-SF	M4flXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofrTWM2OD1yLkC0Nlk4KM7:TR?=	NGfRN3pUSU6JRWK=
MZ7-mel	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHBTWM2OD1yLkC0N\|Mh\|ryP	NEPDWnBUSU6JRWK=
BxPC-3	Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\NXm1iUUN3ME2wMlA1OzRzIN88US=>	MWnTRW5ITVJ?
HT-29	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\5TWM2OD1yLkC0N\|U4KM7:TR?=	MUjTRW5ITVJ?
SK-MEL-30	NHTlXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTBwMESzOlIh\|ryP	NHrVbpRUSU6JRWK=
CAL-33	NWm4ZZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\GTJc3UUN3ME2wMlA1Ozd3IN88US=>	MnP4V2FPT0WU
COLO-680N	MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmHGTWM2OD1yLkC0OFA4KM7:TR?=	MnGxV2FPT0WU
NH-12	M{TyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLJOVd5UUN3ME2wMlA1PDRizszN	Mn63V2FPT0WU
HCC1937	NEXOO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmS5TWM2OD1yLkC0OFU3KM7:TR?=	MVLTRW5ITVJ?
IMR-5	NHHJW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HPO2lEPTB;MD6wOFQ6KM7:TR?=	NWfhdVY5W0GQR1XS
MC-CAR	MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwMES1Olkh\|ryP	MUXTRW5ITVJ?
NCI-H747	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;jZVYzUUN3ME2wMlA1PTdizszN	MmrpV2FPT0WU
NCI-H1792	NFjDW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUfJR\|UxRTBwMES1PFEh\|ryP	M4LjT3NCVkeHUh?=
SW13	NFfMOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHVPZJKSzVyPUCuNFQ2QSEQvF2=	M{Ls[HNCVkeHUh?=
MLMA	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MU\JR\|UxRTBwMES2NFkh\|ryP	MUDTRW5ITVJ?
U251	NEjwUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHOTWM2OD1yLkC0O\|Y{KM7:TR?=	NVjCOnY3W0GQR1XS
U031	M3Xw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2PSVGlEPTB;MD6wOFc4OSEQvF2=	MnTzV2FPT0WU
ME-180	M2Tmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGO1emlKSzVyPUCuNFQ4QDJizszN	M3LkdXNCVkeHUh?=
SK-MEL-3	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTBwMES4NFIh\|ryP	MVPTRW5ITVJ?
MOLT-4	MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTBwMES4NFMh\|ryP	MVTTRW5ITVJ?
PF-382	NIWxUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnQUZVoUUN3ME2wMlA1QDJ4IN88US=>	Mn7WV2FPT0WU
NUGC-3	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2j6NWlEPTB;MD6wOFgzPyEQvF2=	NWT6RWM6W0GQR1XS
NCI-H1417	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3n4WWlEPTB;MD6wOFg6KM7:TR?=	NGHwPHRUSU6JRWK=
COLO-205	NGXoVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnvmTWM2OD1yLkC0PVE6KM7:TR?=	M{XySHNCVkeHUh?=
TE-441-T	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH\Bd4FKSzVyPUCuNFQ6OyEQvF2=	MoXZV2FPT0WU
MKN1	NEHqNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX65cIdpUUN3ME2wMlA1QTNizszN	M2\ReHNCVkeHUh?=
UM-UC-3	Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWPvWWttUUN3ME2wMlA1QTVizszN	NYfFXnNIW0GQR1XS
SF126	MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;MSGlEPTB;MD6wOVAyKM7:TR?=	NIj1bJlUSU6JRWK=
LB1047-RCC	MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PIPGlEPTB;MD6wOVA{OSEQvF2=	MmXWV2FPT0WU
A253	MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWCxeGRYUUN3ME2wMlA2ODV{IN88US=>	NIj1PGRUSU6JRWK=
NCI-H1963	NWXZc4h7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4jGdWlEPTB;MD6wOVE4PiEQvF2=	NHjoTIJUSU6JRWK=
VM-CUB-1	NHHTe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwMEWzNVEh\|ryP	NGPYTpNUSU6JRWK=
T-24	M3vle2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPI[HlKSzVyPUCuNFU{QDRizszN	MYnTRW5ITVJ?
K-562	NHe1WIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEfaOI1KSzVyPUCuNFU{QDdizszN	M1fPS3NCVkeHUh?=
ARH-77	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTHU3hjUUN3ME2wMlA2Ozl3IN88US=>	MX;TRW5ITVJ?
CA46	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2TtTmlEPTB;MD6wOVQ{KM7:TR?=	NITnSpJUSU6JRWK=
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UACC-62	NEDvV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLnT3d3UUN3ME2wMlEzOTJizszN	MlOxV2FPT0WU
C-4-II	M2e0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGfxeo5KSzVyPUCuNVIyPyEQvF2=	NYS3[ItxW0GQR1XS
DMS-53	M4L6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3rtS2lEPTB;MD6xNlI4PiEQvF2=	NUTSSJR3W0GQR1XS
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S-117	M3SzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFqxPGhKSzVyPUCuNVI3PzRizszN	MW\TRW5ITVJ?
ChaGo-K-1	NF71ZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrMTWM2OD1yLkGyOlk6KM7:TR?=	NIK4UFBUSU6JRWK=
KMS-12-PE	MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLzb\|NKSzVyPUCuNVI5PjlizszN	Mnf6V2FPT0WU
PC-3	M3O2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLDNIR7UUN3ME2wMlE{OTd5IN88US=>	NECzRpFUSU6JRWK=
RERF-LC-MS	MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTBwMUO0N{DPxE1?	NIC4NoJUSU6JRWK=
GMS-10	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTBwMUO0OFQh\|ryP	M1\PNHNCVkeHUh?=
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HD-MY-Z	M33Hbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XyfmlEPTB;MD6xOFQzQSEQvF2=	NISzSZBUSU6JRWK=
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U-266	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTBwMUS0PEDPxE1?	MnzLV2FPT0WU
GI-1	M4XjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jlbWlEPTB;MD6xOFc4OiEQvF2=	NVnwTlJtW0GQR1XS
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NCI-H2081	M2q1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nufmlEPTB;MD6xOVIyQCEQvF2=	Mnq0V2FPT0WU
THP-1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVW1U\|k6UUN3ME2wMlE2OzN\|IN88US=>	NED4SoZUSU6JRWK=
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COR-L279	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEPOPFNKSzVyPUCuNVU5OzZizszN	NEiw[nZUSU6JRWK=
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KLE	MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVG5eWRMUUN3ME2wMlE3OTZ7IN88US=>	Mnv0V2FPT0WU
NCI-H2170	NHPvT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\jTWM2OD1yLkG2N\|A1KM7:TR?=	MVrTRW5ITVJ?
TGW	NUDINoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTBwMU[0O\|Eh\|ryP	NETrZWRUSU6JRWK=
CAL-72	NEKxO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13uSGlEPTB;MD6xOlU6KM7:TR?=	NF:1TXBUSU6JRWK=
K052	NFnsb5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIKxRVVKSzVyPUCuNVcxPjFizszN	NGDYeZpUSU6JRWK=
COR-L88	M{m4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDrTXN{UUN3ME2wMlE4OTF2IN88US=>	MkD3V2FPT0WU
HSC-4	M3XPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnOxTWM2OD1yLkG3NVYh\|ryP	NH\o[oZUSU6JRWK=
GOTO	NGXPW\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlfTTWM2OD1yLkG3NlQ3KM7:TR?=	NVjqRnpUW0GQR1XS
MEG-01	M4jaSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLlTWM2OD1yLkG3NlU4KM7:TR?=	NVP6PXluW0GQR1XS
MDA-MB-134-VI	MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MofOTWM2OD1yLkG3N\|Y4KM7:TR?=	MUPTRW5ITVJ?
NCI-H596	NFPWenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkDoTWM2OD1yLkG3N\|gh\|ryP	M1TRfXNCVkeHUh?=
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NCI-H1573	M{HjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLGd5dwUUN3ME2wMlE4Pjd6IN88US=>	M1qybHNCVkeHUh?=
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EGI-1	MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnH1TWM2OD1yLkG3PVch\|ryP	M33pWXNCVkeHUh?=
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NCI-H526	M1jPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUDSU3R5UUN3ME2wMlE5Pjl4IN88US=>	NXnv[ZVVW0GQR1XS
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TE-11	MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUjwcpNXUUN3ME2wMlE6QTd3IN88US=>	MmHaV2FPT0WU
LU-65	MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVvJR\|UxRTBwMkCyNVEh\|ryP	MnfDV2FPT0WU
MKN45	NHvnWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnzQTWM2OD1yLkKwOlQh\|ryP	NI\xeopUSU6JRWK=
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NCI-H1436	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLPTWM2OD1yLkKxPFI3KM7:TR?=	NY[5VHB4W0GQR1XS
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NCI-H2141	NG\0d\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVizNW5xUUN3ME2wMlI{QDRzIN88US=>	MljJV2FPT0WU
LB647-SCLC	NIXGUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NInsOWZKSzVyPUCuNlQxOTRizszN	MX\TRW5ITVJ?
NCI-H23	NVHMcGVzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYHJR\|UxRTBwMkSwOVkh\|ryP	NX\rOVYxW0GQR1XS
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TE-6	NH3XTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXmTWM2OD1yLkK0OlEzKM7:TR?=	M{[2SXNCVkeHUh?=
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MHH-NB-11	NXrRToZUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUXJR\|UxRTBwMkWzOUDPxE1?	M{XG[nNCVkeHUh?=
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OAW-28	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3[3TWlEPTB;MD6yOlY4PyEQvF2=	NVLZTmY{W0GQR1XS
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NCI-H69	NV\OO4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnrITWM2OD1yLkK3NlAyKM7:TR?=	MUHTRW5ITVJ?
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NCI-H1618	NXjlZZdLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYX1b2w5UUN3ME2wMlI4PTFizszN	MlfSV2FPT0WU
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SW684	NELqW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYDScYFyUUN3ME2wMlI5Ozh\|IN88US=>	MXLTRW5ITVJ?
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NCI-H510A	NFnmTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml[3TWM2OD1yLkK5N\|A1KM7:TR?=	MmnHV2FPT0WU
Mo-T	MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPITWM2OD1yLkK5N\|MyKM7:TR?=	M2nxbnNCVkeHUh?=
LB373-MEL-D	MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwMkm0N\|Eh\|ryP	M1jJWnNCVkeHUh?=
NCI-H28	NWLzbItET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{C3OmlEPTB;MD6yPVg{PyEQvF2=	NH32RWhUSU6JRWK=
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OPM-2	NVXWOGR5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVHJR\|UxRTBwM{GwOlQh\|ryP	M4H2cXNCVkeHUh?=
BT-20	NX74R2JqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTWVGNKSzVyPUCuN\|ExQTlizszN	M1rx[nNCVkeHUh?=
KP-N-YN	NFX6RXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTBwM{GxNVgh\|ryP	NHj2cppUSU6JRWK=
MDA-MB-175-VII	NVnnOZhET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXtXFU6UUN3ME2wMlMzOzR6IN88US=>	NG\jPY9USU6JRWK=
EFM-19	NWrIXJdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvrb2czUUN3ME2wMlM{OTN{IN88US=>	MlPuV2FPT0WU
COLO-678	NGHHTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2PsXWlEPTB;MD6zN\|M5QSEQvF2=	M3HvR3NCVkeHUh?=
COLO-829	NFPnV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1rCOGlEPTB;MD6zOFQ2OiEQvF2=	MonQV2FPT0WU
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DMS-114	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfF[\|hjUUN3ME2wMlM3OTJizszN	NHrqOVlUSU6JRWK=
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LB2518-MEL	NVvlbHRQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnnmTWM2OD1yLkSwPFczKM7:TR?=	NF25[llUSU6JRWK=
IST-MES1	M4C3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIXGdXZKSzVyPUCuOFEyKM7:TR?=	NGXIXlRUSU6JRWK=
HPAF-II	NGrmVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXkflNKSzVyPUCuOFEyOTdizszN	MXHTRW5ITVJ?
NCI-H1882	M{PlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTBwNEG3PFQh\|ryP	MV;TRW5ITVJ?
JVM-2	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{\yOGlEPTB;MD60OFQxOSEQvF2=	MXzTRW5ITVJ?
T47D	MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVz2OXpPUUN3ME2wMlQ1PTJ6IN88US=>	NHThbXFUSU6JRWK=
MHH-CALL-2	Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIrN[GRKSzVyPUCuOFQ5OyEQvF2=	M1vmUnNCVkeHUh?=
NCI-H716	MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmCzTWM2OD1yLkS0PFQ5KM7:TR?=	MXXTRW5ITVJ?
NEC8	MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwNEWxOFUh\|ryP	MVfTRW5ITVJ?
UACC-812	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTBwNE[3O\|Yh\|ryP	Mk\MV2FPT0WU
D-502MG	M4HyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIfZfGZKSzVyPUCuOFgxOyEQvF2=	M2C5XXNCVkeHUh?=
CaR-1	Mn;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2r1RWlEPTB;MD61NFM3PyEQvF2=	MlzaV2FPT0WU
LU-139	NX\tVYt{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3NOWptUUN3ME2wMlUyPDV5IN88US=>	Mn7WV2FPT0WU
RPMI-8402	NYXBeVdFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVTJR\|UxRTBwNUKyNFch\|ryP	MoTLV2FPT0WU
SW1088	NIT5fI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVywWG9IUUN3ME2wMlU{QDZ7IN88US=>	MnviV2FPT0WU
JVM-3	M4G0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1HVNWlEPTB;MD61OFEyPyEQvF2=	MkT6V2FPT0WU
YAPC	MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjZTWM2OD1yLkW1NlEyKM7:TR?=	MYHTRW5ITVJ?
KG-1	MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nofWlEPTB;MD61OVk5PCEQvF2=	M4\CeHNCVkeHUh?=
C32	NIHSSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLETWM2OD1yLkW3N\|E{KM7:TR?=	M2HwRnNCVkeHUh?=
IST-SL1	M4i5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfpTWM2OD1yLk[wOFM2KM7:TR?=	MkPxV2FPT0WU
NCI-H2126	MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTBwNkOxOVIh\|ryP	M4fkWXNCVkeHUh?=
HCC1954	NYC1S4dXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTBwNkS3NlYh\|ryP	MY\TRW5ITVJ?
WM-115	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFH5Xo1KSzVyPUCuOlUxQTJizszN	Mm\zV2FPT0WU
NB6	M2rSTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFLuOVFKSzVyPUCuOlc{OzVizszN	MoT6V2FPT0WU
TYK-nu	NX;ld2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFexWWRKSzVyPUCuOlc6PTJizszN	M4iwWnNCVkeHUh?=
KY821	MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYLJR\|UxRTBwN{CyNlkh\|ryP	MnnHV2FPT0WU
SIMA	M2nnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTBwN{G3NVkh\|ryP	MWjTRW5ITVJ?
RCC10RGB	M2TVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPyTWM2OD1yLkexPVE5KM7:TR?=	MXPTRW5ITVJ?
LN-405	NVPiSnJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTBwN{SzOkDPxE1?	Mm\VV2FPT0WU
NCI-H1155	M17PUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVLJR\|UxRTBwN{S4Olgh\|ryP	MYjTRW5ITVJ?
SCLC-21H	NEC3cWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;o[WlEPTB;MD63OlkxOyEQvF2=	M4jmZXNCVkeHUh?=
DMS-79	NYW4N\|lNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvCS\|BjUUN3ME2wMlc4QDR3IN88US=>	NHPQR\|RUSU6JRWK=
EC-GI-10	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1zyOGlEPTB;MD63O\|k4PSEQvF2=	NF2xU5FUSU6JRWK=
KNS-42	M4q2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTBwN{i4N\|Eh\|ryP	NFuxVZVUSU6JRWK=
SNU-475	M{nW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3QTWM2OD1yLke5NlAzKM7:TR?=	M4\Q[HNCVkeHUh?=
SF539	M3X3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwN{m5NlUh\|ryP	NVGwUYRjW0GQR1XS
SW1417	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1O5SGlEPTB;MD64NVM{QSEQvF2=	NEX1cpFUSU6JRWK=
ATN-1	NUDQ[41nT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmPuTWM2OD1yLki1NVE2KM7:TR?=	NYD1WIx5W0GQR1XS
PLC-PRF-5	Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;3THdJUUN3ME2wMlg5PDd3IN88US=>	MWPTRW5ITVJ?
HT-3	NFrGdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPjUGZKSzVyPUCuPFk1OiEQvF2=	M2fm[XNCVkeHUh?=
MDA-MB-453	M4\sWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmnJTWM2OD1yLkmwN\|A1KM7:TR?=	MYjTRW5ITVJ?
HAL-01	MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGTNbohKSzVyPUCuPVk{PzlizszN	MorEV2FPT0WU
NCI-H1993	M2HBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M13VSWlEPTB;MT6wOFY2PyEQvF2=	Mn7yV2FPT0WU
NCI-H2227	NFXqcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37sWmlEPTB;MT6wOFk5OSEQvF2=	MVfTRW5ITVJ?
LP-1	M2X0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PjTWlEPTB;MT6wOlk{KM7:TR?=	NGSzenpUSU6JRWK=
P31-FUJ	NHTXR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTFwMUC3OlYh\|ryP	NGm5SpNUSU6JRWK=
NCI-H64	MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PsPWlEPTB;MT6xOVQzKM7:TR?=	NVG3e4o6W0GQR1XS
SW1463	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHuyXGVKSzVyPUGuNVg{PDlizszN	MY\TRW5ITVJ?
SK-MEL-1	Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;acIVKSzVyPUGuNlA2QTVizszN	MYTTRW5ITVJ?
TALL-1	NFfGU21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmq3TWM2OD1zLkK1NVY2KM7:TR?=	MVPTRW5ITVJ?
RO82-W-1	NXnvWJVTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvZTWM2OD1zLkOzN\|M6KM7:TR?=	MVjTRW5ITVJ?
NCI-H1581	M3XO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTFwM{W2PFch\|ryP	MVjTRW5ITVJ?
NCI-H748	NFnmcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYjLTllNUUN3ME2xMlM2PzN6IN88US=>	NEX2S49USU6JRWK=
HCC1187	NXLCb2dsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofpTWM2OD1zLkW1OVIzKM7:TR?=	M{CzT3NCVkeHUh?=
EoL-1-cell	NV2yR\|dCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTFwNUi4PFkh\|ryP	MkK2V2FPT0WU
HuO-3N1	Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTFwOEO0NVIh\|ryP	NIPU[I1USU6JRWK=
NCI-H1793	M3O5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;CTWM2OD1zLki3OVk{KM7:TR?=	MULTRW5ITVJ?
Caov-3	NGSyfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3ToXmlEPTB;Mj6wNFYzPSEQvF2=	MUfTRW5ITVJ?
JAR	MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTJwMEe5NkDPxE1?	Mlq4V2FPT0WU
SK-MEL-28	MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLzTWM2OD1{LkG4NFk5KM7:TR?=	NEnNeIxUSU6JRWK=
EM-2	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHyTWM2OD1{LkKwNlk{KM7:TR?=	NV;GcWNQW0GQR1XS
Mewo	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEO4PXdKSzVyPUKuNlIzPjVizszN	MmfVV2FPT0WU
NCI-H720	M3nkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml:5TWM2OD1{LkK2OVg2KM7:TR?=	M4nZRnNCVkeHUh?=
CAL-54	M3y4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGTOWY9KSzVyPUKuNlY4QTVizszN	MlrtV2FPT0WU
MC116	NF\6[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXiz[VVnUUN3ME2yMlM3Ozl5IN88US=>	MlGxV2FPT0WU
DG-75	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWntfZhOUUN3ME2yMlQ5PTd4IN88US=>	M{LvTHNCVkeHUh?=
HCC1143	NE[1W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTJwNUC2OVgh\|ryP	MkXHV2FPT0WU
FTC-133	NVG4ZVRyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXvJR\|UxRTJwNUO2PFkh\|ryP	M1XEbHNCVkeHUh?=
AsPC-1	NUPOXnp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofDTWM2OD1{LkWzPVI6KM7:TR?=	MWrTRW5ITVJ?
NCI-H889	MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITiN2tKSzVyPUKuOVY4ODZizszN	MnzUV2FPT0WU
HT55	MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTJwNkKwNVkh\|ryP	Mm\3V2FPT0WU
UMC-11	M2j1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zWTGlEPTB;Mj63PFcyPSEQvF2=	M17xfnNCVkeHUh?=
P12-ICHIKAWA	MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLzcHVKSzVyPUKuPFIxPDZizszN	M37ZZnNCVkeHUh?=
HCC1395	NVnXXW43T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MknhTWM2OD1{Lkm4OlAzKM7:TR?=	NIjsSmxUSU6JRWK=
D-283MED	NEjSUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRTNwMUi5N\|ch\|ryP	Mm\5V2FPT0WU
COLO-800	M{W2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPkWXNKSzVyPUOuN\|M5QTdizszN	Mn\rV2FPT0WU
MFM-223	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYjoeYFsUUN3ME2zMlM3ODl5IN88US=>	Mk\rV2FPT0WU
TE-5	Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWezcllXUUN3ME20MlU3OTR5IN88US=>	NXqyXJFqW0GQR1XS
NCI-H209	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTRwN{i1O\|Ih\|ryP	MnvSV2FPT0WU
SiHa	NHfrZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTRwOUWyNFMh\|ryP	NEjmSIpUSU6JRWK=
NCI-H1395	MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXWzOpJGUUN3ME21MlExPjN\|IN88US=>	MnjRV2FPT0WU
A498	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDpTWhKSzVyPUWuNlEzPTFizszN	MUTTRW5ITVJ?
ES5	NUH2OFNmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn7qTWM2OD13Lk[xNVc5KM7:TR?=	NELJ[oJUSU6JRWK=
MDA-MB-157	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfzTWM2OD13Lk[2OFQ{KM7:TR?=	M4nQUHNCVkeHUh?=
NCI-H1623	MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4j6S2lEPTB;NT64N\|U2PiEQvF2=	MnXPV2FPT0WU
RPMI-8866	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DhW2lEPTB;NT64OFc6OiEQvF2=	M33XXXNCVkeHUh?=
LC-1F	M4T1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV\JR\|UxRTZwMEmyPVEh\|ryP	M1Hjd3NCVkeHUh?=
TCCSUP	NXS1WGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTZwNkCzOFkh\|ryP	M2LLOHNCVkeHUh?=
TT	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTrVnNKSzVyPUiuN\|MxODlizszN	M2H3SXNCVkeHUh?=
NCI-H1838	NXK4ZY5JT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mle1TWM2OD16LkWxO\|MyKM7:TR?=	NX[0[\|B{W0GQR1XS
NCI-H322M	MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTlwMU[yPFEh\|ryP	NW\XWm5iW0GQR1XS
NCI-H187	NGnzWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTUOYFKSzVyPUmuOVE5OzVizszN	NF:xXpJUSU6JRWK=
SBC-1	M123U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2G0TmlEPTB;OT65N\|Y2PiEQvF2=	M2HaeHNCVkeHUh?=
SCC-3	M1;zbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmS0TWM2OD1zMD61Olc6KM7:TR?=	NGDZOYNUSU6JRWK=
SW948	NFnZOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXK3dVN1UUN3ME2xNE44PTFzIN88US=>	MmDLV2FPT0WU
CPC-N	M2TPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTFzLkCwO{DPxE1?	MW\TRW5ITVJ?
TGBC24TKB	NWTQNZFbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFjzSFFKSzVyPUGzMlUzQSEQvF2=	NV\VdJJkW0GQR1XS
NCI-H2452	M1XpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXsd5BkUUN3ME2xOE44OyEQvF2=	NHr3T29USU6JRWK=
Hs-578-T	NXzvV3JmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\P[29SUUN3ME2xPE42PzV7IN88US=>	NVj0N2sxW0GQR1XS
DV-90	NXfGSFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUPJR\|UxRTF6Lkm5OFUh\|ryP	NFrPbJJUSU6JRWK=
NCI-H1563	NEjISm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWDYTXJIUUN3ME2xPU44QDh6IN88US=>	MonkV2FPT0WU
SW780	MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPISWVKSzVyPUKxMlE{OThizszN	MmPKV2FPT0WU
NCI-H345	M4npPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4ewWmlEPTB;MkGuPFc4QSEQvF2=	NHjSN29USU6JRWK=
LB771-HNC	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2n5NWlEPTB;MkKuOFgyOyEQvF2=	NHHJPINUSU6JRWK=
RT4	NVr6Wo13T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYj5dHppUUN3ME2yN{4{Ojh{IN88US=>	NYjJUIxsW0GQR1XS
NCI-H82	NVLTXFNTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2nSdWlEPTB;MkOuOVUzPiEQvF2=	Mk\aV2FPT0WU
NCI-H524	NFjtcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{Ljc2lEPTB;MkSuN\|gyOiEQvF2=	Mmq2V2FPT0WU
SNU-C1	Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLFTWM2OD1{ND65NVA2KM7:TR?=	M1HBRXNCVkeHUh?=
NCI-SNU-16	Mly3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTR6LkOxOFIh\|ryP	M4\vb3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; PubMed: 23993685 Mol Oncol Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein. E-cadherin / Cleaved PARP / Bim; PubMed: 23993685 Mol Oncol Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein. HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; PubMed: 24796583 Oncotarget CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control. CDK4 / HMGA2 ; PubMed: 26893968 PeerJ HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.	23993685 24796583 26893968
Growth inhibition assay	Cell viability; PubMed: 26893968 PeerJ Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. p < 0.05, p < 0.01, **p < 0.001. All experiments were performed in three independent experiments.	26893968

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	- Collapse Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	- Collapse Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	- Collapse Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	AUY-922
Smiles	CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01772797	Completed	Drug: LDK378\|Drug: AUY922	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Drug: AUY922	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Drug: AUY922\|Drug: BYL719	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1
NCT01484860	Terminated	Drug: AUY922	Adenocarcinoma of the Pancreas\|Metastatic Disease	University Health Network Toronto\|Novartis Pharmaceuticals	January 2012	Phase 2
NCT01402401	Terminated	Drug: AUY922 + Trastuzumab	Advanced Gastric Cancer	Novartis Pharmaceuticals\|Novartis	November 2011	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

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Luminespib (NVP-AUY922)