Luminespib (NVP-AUY922)

For research use only. Not for use in humans.

Catalog No.S1069 Synonyms: AUY-922

56 publications

Luminespib (NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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Selleck's Luminespib (NVP-AUY922) has been cited by 56 publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NIHQWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfp[|FqUUN3ME2wMlAxODF{NTFOwG0> M{TYd3NCVkeHUh?=
MV-4-11 NWDYR29tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnCfXhKSzVyPUCuNFAxPTV6IN88US=> MVnTRW5ITVJ?
NALM-6 M{C4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXnbHFKSzVyPUCuNFAxQDR{IN88US=> NXHWPJR1W0GQR1XS
HOS NHLmdJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO3TWM2OD1yLkCwNVM5KM7:TR?= NH3Cd4NUSU6JRWK=
HT-144 MmTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;HNpFzUUN3ME2wMlAxOTV3IN88US=> MYjTRW5ITVJ?
SW1710 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjq[XJqUUN3ME2wMlAxOTh4IN88US=> MkCzV2FPT0WU
TE-8 M2nwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnzWHZKSzVyPUCuNFAzOzdizszN Mmj0V2FPT0WU
ES1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG3RXBOUUN3ME2wMlAxOjZ4IN88US=> NIHJNoxUSU6JRWK=
CCF-STTG1 NYPVdm91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzFN|lKSzVyPUCuNFAzQTdizszN NEj1SmJUSU6JRWK=
PSN1 MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMECzNVgh|ryP NV35SWtpW0GQR1XS
CAL-51 NUXMcVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfNOFJKSzVyPUCuNFA{OjVizszN M2Xs[3NCVkeHUh?=
MCF7 NGnncmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13oOWlEPTB;MD6wNFM{PSEQvF2= Mo[5V2FPT0WU
SK-HEP-1 M4DacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn0[INyUUN3ME2wMlAxOzN4IN88US=> NGHmbJpUSU6JRWK=
LCLC-103H M1PKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPqTpFKSzVyPUCuNFA1OyEQvF2= NGe2c4pUSU6JRWK=
HMV-II MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X5d2lEPTB;MD6wNFQ1QSEQvF2= MXvTRW5ITVJ?
MES-SA NXuzTo1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfWTWM2OD1yLkCwOFUzKM7:TR?= MX7TRW5ITVJ?
SK-LMS-1 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[zd3Z6UUN3ME2wMlAxPDV6IN88US=> MXnTRW5ITVJ?
639-V NIrFS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEC0PFUh|ryP NVT6ZVFNW0GQR1XS
SIG-M5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i1cWlEPTB;MD6wNFQ5QSEQvF2= Mlj2V2FPT0WU
LOUCY NF;JR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPqV5NYUUN3ME2wMlAxPTB3IN88US=> MmTzV2FPT0WU
HSC-2 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHEc4VkUUN3ME2wMlAxPTF6IN88US=> M4OzeXNCVkeHUh?=
EW-13 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;hZndKSzVyPUCuNFA2OThizszN Mmj6V2FPT0WU
RT-112 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEC1N|Uh|ryP MXTTRW5ITVJ?
NKM-1 M{[2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXYTWM2OD1yLkCwOVQ4KM7:TR?= NHLPVHdUSU6JRWK=
KYSE-180 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHkWXlKSzVyPUCuNFA2QDZizszN MYXTRW5ITVJ?
SW1783 NHHtOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\HeIFKSzVyPUCuNFA2QTFizszN MmjOV2FPT0WU
A431 M2rv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXSTWM2OD1yLkCwOlA4KM7:TR?= MoPqV2FPT0WU
SK-OV-3 M{XjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPr[GVVUUN3ME2wMlAxPjNizszN MXTTRW5ITVJ?
RPMI-7951 M1rOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEC2N|Eh|ryP MkLnV2FPT0WU
Capan-2 NVvoTZBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHzUVNKSzVyPUCuNFA3OzhizszN MmTsV2FPT0WU
HSC-3 NGPHcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH4TWM2OD1yLkCwOlQyKM7:TR?= NGDpZpNUSU6JRWK=
786-0 NI\PXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYniNmtkUUN3ME2wMlAxPjZ|IN88US=> MYnTRW5ITVJ?
Daoy M1zyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qyO2lEPTB;MD6wNFY6PSEQvF2= Mlf1V2FPT0WU
KGN NYDENnFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDTRYRKSzVyPUCuNFA4ODNizszN Ml;CV2FPT0WU
EW-16 NIPqTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3aTWM2OD1yLkCwO|Q6KM7:TR?= MnTlV2FPT0WU
EW-7 NFrjS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPmTWM2OD1yLkCwO|U1KM7:TR?= Mn7rV2FPT0WU
IGROV-1 M2HaTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq5TWM2OD1yLkCwPFE1KM7:TR?= MmrYV2FPT0WU
8505C MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEC4NlEh|ryP MVvTRW5ITVJ?
RKO MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEC4NlYh|ryP NVHpNm5oW0GQR1XS
GDM-1 NH6xUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTyTWM2OD1yLkCwPFQh|ryP NFnxbo9USU6JRWK=
IST-MEL1 M3y5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEC4OVIh|ryP MVHTRW5ITVJ?
RPMI-6666 NWTpXJhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvvOY1KSzVyPUCuNFA5PTJizszN M1nMWXNCVkeHUh?=
SNG-M NXm3SmdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEC4OVYh|ryP NEXwT5NUSU6JRWK=
KS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaTWM2OD1yLkCwPFU6KM7:TR?= Mk\KV2FPT0WU
RXF393 M1HJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLod25sUUN3ME2wMlAxQDZizszN MXXTRW5ITVJ?
CAL-12T NYXZUZh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K0UmlEPTB;MD6wNFkzOiEQvF2= MmL4V2FPT0WU
BFTC-905 M4TOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjPTWM2OD1yLkCwPVM5KM7:TR?= M3ThdnNCVkeHUh?=
SK-MES-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC5OFUh|ryP M33TUnNCVkeHUh?=
BB30-HNC M4jnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LObWlEPTB;MD6wNFk2OiEQvF2= NIDZfWFUSU6JRWK=
AN3-CA NIf2UnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPzcI5KSzVyPUCuNFExOTdizszN MVXTRW5ITVJ?
EFO-27 MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrKTWM2OD1yLkCxNFE4KM7:TR?= M1f3XnNCVkeHUh?=
G-401 M3zEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XNUGlEPTB;MD6wNVAzPSEQvF2= M3rLd3NCVkeHUh?=
BPH-1 M{fWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq5Z5JKSzVyPUCuNFExOyEQvF2= NFP5Nm1USU6JRWK=
NCI-H727 NWGxUmNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi4WGJUUUN3ME2wMlAyODNizszN NVHjT4p1W0GQR1XS
SNU-423 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\LUWV4UUN3ME2wMlAyODV|IN88US=> M4TVcXNCVkeHUh?=
KYSE-270 NWGwdFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\iPYYyUUN3ME2wMlAyODV7IN88US=> NH\6R3ZUSU6JRWK=
AGS Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj1TWM2OD1yLkCxNFYyKM7:TR?= MX;TRW5ITVJ?
NCI-H2228 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTjTWM2OD1yLkCxNFY1KM7:TR?= NXPpPHNvW0GQR1XS
SW954 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQ[GpKSzVyPUCuNFExPzFizszN M{XGWXNCVkeHUh?=
769-P Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ezOWlEPTB;MD6wNVA4OyEQvF2= M2juW3NCVkeHUh?=
BB49-HNC M2r3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEGwO|ch|ryP MmjSV2FPT0WU
IA-LM Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnVbYlKSzVyPUCuNFExQDZizszN NHfKeFVUSU6JRWK=
NB69 M1zETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEGxNFIh|ryP MlPIV2FPT0WU
C8166 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvsW3FKSzVyPUCuNFEyOjlizszN Mo\OV2FPT0WU
NCI-H1299 NIixXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHpeFVKSzVyPUCuNFEyPTRizszN NWW0XZB4W0GQR1XS
YKG-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELFOYdKSzVyPUCuNFEyPiEQvF2= MnfJV2FPT0WU
PANC-03-27 NGPpfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLJTWM2OD1yLkCxNVYzKM7:TR?= M37KXXNCVkeHUh?=
YT M{fIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOwS45KSzVyPUCuNFEyPzlizszN Ml:0V2FPT0WU
CAL-85-1 M4XoSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXNTWM2OD1yLkCxNVkzKM7:TR?= M4\kOHNCVkeHUh?=
GT3TKB NV;kVpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDhdGdKSzVyPUCuNFEzODJizszN NIfQVXBUSU6JRWK=
BB65-RCC NEnzR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEGyNFQh|ryP MojFV2FPT0WU
ES6 NGK2UYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rTOWlEPTB;MD6wNVI3OSEQvF2= NGXVS4pUSU6JRWK=
MHH-ES-1 NWHwZ4x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX2fGd2UUN3ME2wMlAyOjZ|IN88US=> MWHTRW5ITVJ?
QIMR-WIL NHnRRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXCdmpKSzVyPUCuNFEzPjlizszN NYrxZ4R6W0GQR1XS
SNU-C2B NHe1PHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEGyO|Ih|ryP M3f2bHNCVkeHUh?=
OCI-AML2 NXu3S|g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHwTWM2OD1yLkCxNlgyKM7:TR?= NGPINGVUSU6JRWK=
DU-145 NEW3TYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEGyPUDPxE1? MWHTRW5ITVJ?
SW982 M33YOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXRZpZKSzVyPUCuNFEzQTNizszN NILqeVNUSU6JRWK=
MFH-ino NImxc5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEGyPVMh|ryP NF[2bXBUSU6JRWK=
A427 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;PTWM2OD1yLkCxNlk6KM7:TR?= MYTTRW5ITVJ?
LCLC-97TM1 M{fYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEGzJO69VQ>? NVvyWnl3W0GQR1XS
AM-38 M1WzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPGTWM2OD1yLkCxN|AzKM7:TR?= NEfRT5hUSU6JRWK=
K5 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHkZWt6UUN3ME2wMlAyOzB6IN88US=> MWjTRW5ITVJ?
T84 NIHVW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\yUW9uUUN3ME2wMlAyOzNzIN88US=> M4\0XXNCVkeHUh?=
TE-15 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfwTWM2OD1yLkCxN|M3KM7:TR?= NI\C[ndUSU6JRWK=
NCI-H460 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\O[2lEPTB;MD6wNVM{PiEQvF2= M3Tp[HNCVkeHUh?=
NTERA-S-cl-D1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEGzN|kh|ryP MWnTRW5ITVJ?
KYSE-450 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPUVXlKSzVyPUCuNFE{PDlizszN MmHCV2FPT0WU
H4 M1nHc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEGzOlYh|ryP M1rOR3NCVkeHUh?=
LC-2-ad NHSxboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW2W|ZKSzVyPUCuNFE{PyEQvF2= NVmwWnAzW0GQR1XS
GAMG M1;qW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEGzO|Eh|ryP MoDNV2FPT0WU
TK10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j4PGlEPTB;MD6wNVM5OiEQvF2= M{PLVnNCVkeHUh?=
NCI-H2122 NH3Rb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC0dnhKSzVyPUCuNFE{QDRizszN M1TKbXNCVkeHUh?=
KM12 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3pSZN3UUN3ME2wMlAyOzl7IN88US=> M4\0bnNCVkeHUh?=
CAL-39 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3xTWM2OD1yLkCxOFIh|ryP M1j1OHNCVkeHUh?=
RPMI-2650 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjmbZprUUN3ME2wMlAyPDN{IN88US=> M36zeXNCVkeHUh?=
KYSE-510 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEG0OFIh|ryP MUfTRW5ITVJ?
KALS-1 NEmyb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEG0OlYh|ryP M1zxTXNCVkeHUh?=
NCI-H1648 NHLVZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP1WFhKSzVyPUCuNFE1QTlizszN NGmybHZUSU6JRWK=
ES4 M1LsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjZR3ZKSzVyPUCuNFE2ODJizszN NY\EU|RQW0GQR1XS
C-33-A NXTBc4FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT2NZJ3UUN3ME2wMlAyPTB7IN88US=> NHTicVVUSU6JRWK=
MIA-PaCa-2 MoXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2riemlEPTB;MD6wNVUxQSEQvF2= NV\teHJrW0GQR1XS
Becker NX\HSm5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDmTWM2OD1yLkCxOVE1KM7:TR?= MkDOV2FPT0WU
HOP-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXo[|VKSzVyPUCuNFE2PDJizszN Mmf4V2FPT0WU
TE-1 M{HIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEG1PFEh|ryP NYrMOWlSW0GQR1XS
KYSE-410 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEG1PFYh|ryP M2PrfXNCVkeHUh?=
NOS-1 NHvq[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEG1PVMh|ryP MV3TRW5ITVJ?
MEL-HO M4HlOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDjOIpiUUN3ME2wMlAyPjR|IN88US=> MV3TRW5ITVJ?
NCI-H1650 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjqTWM2OD1yLkCxOlQ3KM7:TR?= MmXOV2FPT0WU
VMRC-RCZ NFf6XXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLPUo5KSzVyPUCuNFE3PTFizszN MmraV2FPT0WU
HuP-T3 M3joUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEG2OVMh|ryP NUjicGhyW0GQR1XS
ACN NHP1d5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEG2OVch|ryP M3rrcHNCVkeHUh?=
MEL-JUSO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWxOZVkUUN3ME2wMlAyPjhzIN88US=> NXrMbGdbW0GQR1XS
HT-1197 M1TJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfoSlhKSzVyPUCuNFE3QDVizszN M4T0eXNCVkeHUh?=
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SF268 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS5WpQ6UUN3ME2wMlA{PDBzIN88US=> NWCzWIxlW0GQR1XS
BV-173 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHZTWM2OD1yLkCzOFI3KM7:TR?= MW\TRW5ITVJ?
DMS-273 NHLz[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXEc4ZKSzVyPUCuNFM1PzlizszN MlzjV2FPT0WU
22RV1 NHPJb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEO1NFch|ryP NI\Qe2JUSU6JRWK=
ES8 M3e4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEO1N|gh|ryP MkG2V2FPT0WU
KYSE-150 NYn6fXdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7ZT45KSzVyPUCuNFM3ODhizszN M1z5SnNCVkeHUh?=
HCC1569 MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXPXVEzUUN3ME2wMlA{PjB6IN88US=> NGnWUXZUSU6JRWK=
NB5 NEWw[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj5TWM2OD1yLkCzOlE{KM7:TR?= MnrhV2FPT0WU
G-402 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO5PIFKSzVyPUCuNFM3OTRizszN NVfyeGxUW0GQR1XS
NCI-H1693 M2TzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTRTWM2OD1yLkCzOlE4KM7:TR?= Mn\hV2FPT0WU
LB2241-RCC NEnwOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjWO3FKSzVyPUCuNFM3PDJizszN M3rSNHNCVkeHUh?=
KP-4 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrS[|A6UUN3ME2wMlA{PjZ|IN88US=> MUDTRW5ITVJ?
ML-2 M4\lXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkOwTWM2OD1yLkCzOlcyKM7:TR?= NWLYd5ZlW0GQR1XS
KU812 NUPHVmQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mx[GlEPTB;MD6wN|Y5PCEQvF2= MlnPV2FPT0WU
LS-411N MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEO3N|Eh|ryP NEO5[2xUSU6JRWK=
OAW-42 M3j1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLkTWM2OD1yLkCzO|Q4KM7:TR?= NFf2VHhUSU6JRWK=
HCC38 NVfydlZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\uTGlEPTB;MD6wN|c4OSEQvF2= MlnuV2FPT0WU
Ca-Ski MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEO3PFQh|ryP M1;MdXNCVkeHUh?=
Calu-3 NUD6R4g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13nR2lEPTB;MD6wN|c5QSEQvF2= NXjHd|RyW0GQR1XS
KYSE-70 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD5TWM2OD1yLkCzPFEzKM7:TR?= MlnnV2FPT0WU
D-392MG NHLwTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHKwbJNKSzVyPUCuNFM5PDJizszN NGnEfmFUSU6JRWK=
OVCAR-4 M{TBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH61Vm9KSzVyPUCuNFM5PThizszN NYTac2VmW0GQR1XS
Detroit562 NGHaSHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3VN5RKSzVyPUCuNFM5PzJizszN NHTZT3lUSU6JRWK=
HEL M3vJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEO4PVEh|ryP NV7zN4p6W0GQR1XS
MONO-MAC-6 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEO4PVMh|ryP NXXHZ4RGW0GQR1XS
LoVo M2foWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEO5N|Mh|ryP NHr3cWFUSU6JRWK=
U-2-OS NGLUd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT5TWM2OD1yLkCzPVM2KM7:TR?= NWO4RoZ7W0GQR1XS
A172 NXO5UmFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEO5OUDPxE1? NXmwTHJ6W0GQR1XS
OCUB-M NWLVU2ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\KTWM2OD1yLkCzPVYyKM7:TR?= NUH0NVg5W0GQR1XS
SW48 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrzTWM2OD1yLkC0NFMyKM7:TR?= Mn;oV2FPT0WU
HC-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHtcFNKSzVyPUCuNFQxPjlizszN MoDpV2FPT0WU
KOSC-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nvUmlEPTB;MD6wOFEyKM7:TR?= NVzoRXpTW0GQR1XS
HDLM-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCNWlEPTB;MD6wOFEyPCEQvF2= NFm1V3hUSU6JRWK=
CTV-1 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOxfmpKSzVyPUCuNFQyOTZizszN MmfPV2FPT0WU
SH-4 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\hXI5oUUN3ME2wMlA1OTRzIN88US=> NH25U|NUSU6JRWK=
SW756 NHeyXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMESxOVch|ryP NHjBW3FUSU6JRWK=
GCT NV[3TJM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPCTWM2OD1yLkC0NVYyKM7:TR?= NVLydGgzW0GQR1XS
CHL-1 M2HPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\GNWFIUUN3ME2wMlA1OTZ7IN88US=> M4XY[3NCVkeHUh?=
LAMA-84 MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;EfXFLUUN3ME2wMlA1OTdzIN88US=> M4XwSHNCVkeHUh?=
LS-1034 M4XS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMESxPVEh|ryP NXHHcphbW0GQR1XS
NCI-H358 MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq4TWM2OD1yLkC0NlEzKM7:TR?= MnjmV2FPT0WU
NB13 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMESyNlch|ryP MWPTRW5ITVJ?
TE-9 Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\rTWM2OD1yLkC0NlM4KM7:TR?= NIrEeYJUSU6JRWK=
OE33 NEXnXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nSSWlEPTB;MD6wOFI1OSEQvF2= MWTTRW5ITVJ?
CAL-120 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi0N|BKSzVyPUCuNFQzPDFizszN NYHHSJFnW0GQR1XS
DJM-1 NHuzRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHubGZQUUN3ME2wMlA1Ojd{IN88US=> Mlm4V2FPT0WU
SK-MEL-24 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMESyPFMh|ryP NFXnXZZUSU6JRWK=
VA-ES-BJ M4HHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnoTWM2OD1yLkC0NlkzKM7:TR?= M4rocHNCVkeHUh?=
MMAC-SF M4flXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofrTWM2OD1yLkC0Nlk4KM7:TR?= NGfRN3pUSU6JRWK=
MZ7-mel MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHBTWM2OD1yLkC0N|Mh|ryP NEPDWnBUSU6JRWK=
BxPC-3 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\NXm1iUUN3ME2wMlA1OzRzIN88US=> MWnTRW5ITVJ?
HT-29 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5TWM2OD1yLkC0N|U4KM7:TR?= MUjTRW5ITVJ?
SK-MEL-30 NHTlXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMESzOlIh|ryP NHrVbpRUSU6JRWK=
CAL-33 NWm4ZZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\GTJc3UUN3ME2wMlA1Ozd3IN88US=> MnP4V2FPT0WU
COLO-680N MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHGTWM2OD1yLkC0OFA4KM7:TR?= MnGxV2FPT0WU
NH-12 M{TyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLJOVd5UUN3ME2wMlA1PDRizszN Mn63V2FPT0WU
HCC1937 NEXOO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS5TWM2OD1yLkC0OFU3KM7:TR?= MVLTRW5ITVJ?
IMR-5 NHHJW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HPO2lEPTB;MD6wOFQ6KM7:TR?= NWfhdVY5W0GQR1XS
MC-CAR MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMES1Olkh|ryP MUXTRW5ITVJ?
NCI-H747 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;jZVYzUUN3ME2wMlA1PTdizszN MmrpV2FPT0WU
NCI-H1792 NFjDW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMES1PFEh|ryP M4LjT3NCVkeHUh?=
SW13 NFfMOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHVPZJKSzVyPUCuNFQ2QSEQvF2= M{Ls[HNCVkeHUh?=
MLMA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMES2NFkh|ryP MUDTRW5ITVJ?
U251 NEjwUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHOTWM2OD1yLkC0O|Y{KM7:TR?= NVjCOnY3W0GQR1XS
U031 M3Xw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PSVGlEPTB;MD6wOFc4OSEQvF2= MnTzV2FPT0WU
ME-180 M2Tmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO1emlKSzVyPUCuNFQ4QDJizszN M3LkdXNCVkeHUh?=
SK-MEL-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMES4NFIh|ryP MVPTRW5ITVJ?
MOLT-4 MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMES4NFMh|ryP MVTTRW5ITVJ?
PF-382 NIWxUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnQUZVoUUN3ME2wMlA1QDJ4IN88US=> Mn7WV2FPT0WU
NUGC-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j6NWlEPTB;MD6wOFgzPyEQvF2= NWT6RWM6W0GQR1XS
NCI-H1417 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n4WWlEPTB;MD6wOFg6KM7:TR?= NGHwPHRUSU6JRWK=
COLO-205 NGXoVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvmTWM2OD1yLkC0PVE6KM7:TR?= M{XySHNCVkeHUh?=
TE-441-T MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Bd4FKSzVyPUCuNFQ6OyEQvF2= MoXZV2FPT0WU
MKN1 NEHqNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX65cIdpUUN3ME2wMlA1QTNizszN M2\ReHNCVkeHUh?=
UM-UC-3 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPvWWttUUN3ME2wMlA1QTVizszN NYfFXnNIW0GQR1XS
SF126 MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;MSGlEPTB;MD6wOVAyKM7:TR?= NIj1bJlUSU6JRWK=
LB1047-RCC MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PIPGlEPTB;MD6wOVA{OSEQvF2= MmXWV2FPT0WU
A253 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCxeGRYUUN3ME2wMlA2ODV{IN88US=> NIj1PGRUSU6JRWK=
NCI-H1963 NWXZc4h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jGdWlEPTB;MD6wOVE4PiEQvF2= NHjoTIJUSU6JRWK=
VM-CUB-1 NHHTe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEWzNVEh|ryP NGPYTpNUSU6JRWK=
T-24 M3vle2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPI[HlKSzVyPUCuNFU{QDRizszN MYnTRW5ITVJ?
K-562 NHe1WIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfaOI1KSzVyPUCuNFU{QDdizszN M1fPS3NCVkeHUh?=
ARH-77 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTHU3hjUUN3ME2wMlA2Ozl3IN88US=> MX;TRW5ITVJ?
CA46 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TtTmlEPTB;MD6wOVQ{KM7:TR?= NITnSpJUSU6JRWK=
HCC70 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfYOGVjUUN3ME2wMlA2PDV{IN88US=> MUTTRW5ITVJ?
ST486 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{flb2lEPTB;MD6wOVUzPSEQvF2= NXr2NmJZW0GQR1XS
COLO-741 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fkNWlEPTB;MD6wOVU{OSEQvF2= MlToV2FPT0WU
SK-PN-DW M4ni[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj1SXZKSzVyPUCuNFU2QDhizszN MorlV2FPT0WU
BL-41 NX7HSmd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXrTWM2OD1yLkC1OVk3KM7:TR?= NEn3Z4pUSU6JRWK=
D-263MG MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TTUGlEPTB;MD6wOVY5OyEQvF2= NUXzXFNWW0GQR1XS
KE-37 M1fBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEW2PFMh|ryP MoXsV2FPT0WU
LU-134-A MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfGTWM2OD1yLkC1O|E2KM7:TR?= NFrpUYNUSU6JRWK=
HCC2157 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEW3N|Mh|ryP NV\IS2doW0GQR1XS
GAK NUjqcohOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv0N|JKSzVyPUCuNFU4OzRizszN NHfUOYVUSU6JRWK=
IST-SL2 M4PIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEW3OFMh|ryP MoDEV2FPT0WU
KMOE-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn3[Y1KSzVyPUCuNFU4PDlizszN M4SweHNCVkeHUh?=
SW1573 NX;Sfm1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPuTWM2OD1yLkC1PFAzKM7:TR?= NYfGcllWW0GQR1XS
SCC-9 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEW4O{DPxE1? MYjTRW5ITVJ?
MDA-MB-361 NULiUVBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEW4O|Ih|ryP MVPTRW5ITVJ?
BHT-101 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPYcIxKSzVyPUCuNFU5PzZizszN NWDUPHNxW0GQR1XS
NCI-H1770 NYLrO5ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEW4O|kh|ryP Ml\ZV2FPT0WU
UACC-893 M1vEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEW4PVYh|ryP MnrtV2FPT0WU
NCI-H226 MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi1XnlKSzVyPUCuNFU6QDhizszN MonxV2FPT0WU
HLE NVXCPVA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zkemlEPTB;MD6wOlA5OiEQvF2= NIHFWXBUSU6JRWK=
NCI-H1703 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHToVmFKSzVyPUCuNFYyPzhizszN MYPTRW5ITVJ?
KURAMOCHI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwME[xPFkh|ryP MmrZV2FPT0WU
RH-1 NWTNO2o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrFSmdvUUN3ME2wMlA3OjNizszN NUTZe3BCW0GQR1XS
DSH1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\sNIVKSzVyPUCuNFYzPyEQvF2= M{XnS3NCVkeHUh?=
CAMA-1 M1jJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTGTWM2OD1yLkC2N|A{KM7:TR?= NV;1b3hxW0GQR1XS
NCI-H1437 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HCVWlEPTB;MD6wOlMzQCEQvF2= MWDTRW5ITVJ?
HuP-T4 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzF[YNKSzVyPUCuNFY2QDZizszN NUL3[W92W0GQR1XS
HCT-15 MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W1NWlEPTB;MD6wOlU6PyEQvF2= NUTYXYpiW0GQR1XS
NCCIT MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LiXWlEPTB;MD6wOlYxPCEQvF2= M1f4dnNCVkeHUh?=
BOKU NVLENZVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fXPGlEPTB;MD6wOlY4PCEQvF2= MYnTRW5ITVJ?
FADU MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETSPFBKSzVyPUCuNFY4PDVizszN MnjCV2FPT0WU
SUP-T1 NGfJZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLQTWM2OD1yLkC2O|Yh|ryP NXLVZ2VvW0GQR1XS
L-363 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fWbWlEPTB;MD6wOlkxOSEQvF2= NVOxTnFmW0GQR1XS
KNS-81-FD M4\qOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfLZ5pKSzVyPUCuNFY6OThizszN MUDTRW5ITVJ?
SU-DHL-1 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfSTWM2OD1yLkC2PVIh|ryP M4\lZ3NCVkeHUh?=
HuH-7 NUXYe4NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:wUGRKSzVyPUCuNFcxOzVizszN NYLYUoN5W0GQR1XS
BT-474 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3kR3FKSzVyPUCuNFcxPjFizszN NEftUnBUSU6JRWK=
CAPAN-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHuemRtUUN3ME2wMlA4OTR|IN88US=> NGLQcpZUSU6JRWK=
HEC-1 M37BUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzwTWM2OD1yLkC3NVYyKM7:TR?= NGSySWdUSU6JRWK=
NOMO-1 NH[4fVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PidGlEPTB;MD6wO|E4OiEQvF2= NVzBWHFwW0GQR1XS
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RPMI-8402 NYXBeVdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwNUKyNFch|ryP MoTLV2FPT0WU
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RCC10RGB M2TVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPyTWM2OD1yLkexPVE5KM7:TR?= MXPTRW5ITVJ?
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NCI-H1581 M3XO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFwM{W2PFch|ryP MVjTRW5ITVJ?
NCI-H748 NFnmcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjLTllNUUN3ME2xMlM2PzN6IN88US=> NEX2S49USU6JRWK=
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EoL-1-cell NV2yR|dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwNUi4PFkh|ryP MkK2V2FPT0WU
HuO-3N1 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwOEO0NVIh|ryP NIPU[I1USU6JRWK=
NCI-H1793 M3O5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;CTWM2OD1zLki3OVk{KM7:TR?= MULTRW5ITVJ?
Caov-3 NGSyfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ToXmlEPTB;Mj6wNFYzPSEQvF2= MUfTRW5ITVJ?
JAR MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwMEe5NkDPxE1? Mlq4V2FPT0WU
SK-MEL-28 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLzTWM2OD1{LkG4NFk5KM7:TR?= NEnNeIxUSU6JRWK=
EM-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHyTWM2OD1{LkKwNlk{KM7:TR?= NV;GcWNQW0GQR1XS
Mewo MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO4PXdKSzVyPUKuNlIzPjVizszN MmfVV2FPT0WU
NCI-H720 M3nkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:5TWM2OD1{LkK2OVg2KM7:TR?= M4nZRnNCVkeHUh?=
CAL-54 M3y4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTOWY9KSzVyPUKuNlY4QTVizszN MlrtV2FPT0WU
MC116 NF\6[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXiz[VVnUUN3ME2yMlM3Ozl5IN88US=> MlGxV2FPT0WU
DG-75 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWntfZhOUUN3ME2yMlQ5PTd4IN88US=> M{LvTHNCVkeHUh?=
HCC1143 NE[1W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwNUC2OVgh|ryP MkXHV2FPT0WU
FTC-133 NVG4ZVRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwNUO2PFkh|ryP M1XEbHNCVkeHUh?=
AsPC-1 NUPOXnp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofDTWM2OD1{LkWzPVI6KM7:TR?= MWrTRW5ITVJ?
NCI-H889 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITiN2tKSzVyPUKuOVY4ODZizszN MnzUV2FPT0WU
HT55 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJwNkKwNVkh|ryP Mm\3V2FPT0WU
UMC-11 M2j1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zWTGlEPTB;Mj63PFcyPSEQvF2= M17xfnNCVkeHUh?=
P12-ICHIKAWA MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzcHVKSzVyPUKuPFIxPDZizszN M37ZZnNCVkeHUh?=
HCC1395 NVnXXW43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknhTWM2OD1{Lkm4OlAzKM7:TR?= NIjsSmxUSU6JRWK=
D-283MED NEjSUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTNwMUi5N|ch|ryP Mm\5V2FPT0WU
COLO-800 M{W2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPkWXNKSzVyPUOuN|M5QTdizszN Mn\rV2FPT0WU
MFM-223 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjoeYFsUUN3ME2zMlM3ODl5IN88US=> Mk\rV2FPT0WU
TE-5 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWezcllXUUN3ME20MlU3OTR5IN88US=> NXqyXJFqW0GQR1XS
NCI-H209 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTRwN{i1O|Ih|ryP MnvSV2FPT0WU
SiHa NHfrZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTRwOUWyNFMh|ryP NEjmSIpUSU6JRWK=
NCI-H1395 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWzOpJGUUN3ME21MlExPjN|IN88US=> MnjRV2FPT0WU
A498 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDpTWhKSzVyPUWuNlEzPTFizszN MUTTRW5ITVJ?
ES5 NUH2OFNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7qTWM2OD13Lk[xNVc5KM7:TR?= NELJ[oJUSU6JRWK=
MDA-MB-157 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfzTWM2OD13Lk[2OFQ{KM7:TR?= M4nQUHNCVkeHUh?=
NCI-H1623 MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j6S2lEPTB;NT64N|U2PiEQvF2= MnXPV2FPT0WU
RPMI-8866 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DhW2lEPTB;NT64OFc6OiEQvF2= M33XXXNCVkeHUh?=
LC-1F M4T1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTZwMEmyPVEh|ryP M1Hjd3NCVkeHUh?=
TCCSUP NXS1WGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTZwNkCzOFkh|ryP M2LLOHNCVkeHUh?=
TT MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTrVnNKSzVyPUiuN|MxODlizszN M2H3SXNCVkeHUh?=
NCI-H1838 NXK4ZY5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle1TWM2OD16LkWxO|MyKM7:TR?= NX[0[|B{W0GQR1XS
NCI-H322M MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTlwMU[yPFEh|ryP NW\XWm5iW0GQR1XS
NCI-H187 NGnzWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTUOYFKSzVyPUmuOVE5OzVizszN NF:xXpJUSU6JRWK=
SBC-1 M123U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G0TmlEPTB;OT65N|Y2PiEQvF2= M2HaeHNCVkeHUh?=
SCC-3 M1;zbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS0TWM2OD1zMD61Olc6KM7:TR?= NGDZOYNUSU6JRWK=
SW948 NFnZOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXK3dVN1UUN3ME2xNE44PTFzIN88US=> MmDLV2FPT0WU
CPC-N M2TPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFzLkCwO{DPxE1? MW\TRW5ITVJ?
TGBC24TKB NWTQNZFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjzSFFKSzVyPUGzMlUzQSEQvF2= NV\VdJJkW0GQR1XS
NCI-H2452 M1XpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXsd5BkUUN3ME2xOE44OyEQvF2= NHr3T29USU6JRWK=
Hs-578-T NXzvV3JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\P[29SUUN3ME2xPE42PzV7IN88US=> NVj0N2sxW0GQR1XS
DV-90 NXfGSFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF6Lkm5OFUh|ryP NFrPbJJUSU6JRWK=
NCI-H1563 NEjISm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDYTXJIUUN3ME2xPU44QDh6IN88US=> MonkV2FPT0WU
SW780 MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPISWVKSzVyPUKxMlE{OThizszN MmPKV2FPT0WU
NCI-H345 M4npPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ewWmlEPTB;MkGuPFc4QSEQvF2= NHjSN29USU6JRWK=
LB771-HNC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n5NWlEPTB;MkKuOFgyOyEQvF2= NHHJPINUSU6JRWK=
RT4 NVr6Wo13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj5dHppUUN3ME2yN{4{Ojh{IN88US=> NYjJUIxsW0GQR1XS
NCI-H82 NVLTXFNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nSdWlEPTB;MkOuOVUzPiEQvF2= Mk\aV2FPT0WU
NCI-H524 NFjtcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Ljc2lEPTB;MkSuN|gyOiEQvF2= Mmq2V2FPT0WU
SNU-C1 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLFTWM2OD1{ND65NVA2KM7:TR?= M1HBRXNCVkeHUh?=
NCI-SNU-16 Mly3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTR6LkOxOFIh|ryP M4\vb3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; 

PubMed: 23993685     


Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein.

E-cadherin / Cleaved PARP / Bim; 

PubMed: 23993685     


Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein.

HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; 

PubMed: 24796583     


CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control.

CDK4 / HMGA2 ; 

PubMed: 26893968     


HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.

23993685 24796583 26893968
Growth inhibition assay
Cell viability; 

PubMed: 26893968     


Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed in three independent experiments.

26893968
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
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Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
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  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms AUY-922
Smiles CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
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    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Drug: AUY922 Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Drug: AUY922|Drug: BYL719 Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1
NCT01484860 Terminated Drug: AUY922 Adenocarcinoma of the Pancreas|Metastatic Disease University Health Network Toronto|Novartis Pharmaceuticals January 2012 Phase 2
NCT01402401 Terminated Drug: AUY922 + Trastuzumab Advanced Gastric Cancer Novartis Pharmaceuticals|Novartis November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID