Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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Cited by 47 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NH7rflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLTeY9KSzVyPUCuNFAxOTJ3IN88US=> NYHsOlNVW0GQR1XS
MV-4-11 NUnO[XlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;0UlBYUUN3ME2wMlAxODV3ODFOwG0> MofCV2FPT0WU
NALM-6 M1nRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMECwPFQzKM7:TR?= MnLXV2FPT0WU
HOS NX3XOHFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Prb2lEPTB;MD6wNFE{QCEQvF2= Mn3oV2FPT0WU
HT-144 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlntTWM2OD1yLkCwNVU2KM7:TR?= MYrTRW5ITVJ?
SW1710 NWiyWFhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf0RZlVUUN3ME2wMlAxOTh4IN88US=> MkHZV2FPT0WU
TE-8 NWPxSGt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWxTWM2OD1yLkCwNlM4KM7:TR?= NWi5OHQ5W0GQR1XS
ES1 NYrGSVR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\nS2lEPTB;MD6wNFI3PiEQvF2= Mn3FV2FPT0WU
CCF-STTG1 M4nZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PaZmlEPTB;MD6wNFI6PyEQvF2= MXjTRW5ITVJ?
PSN1 NYr1PG5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fXWWlEPTB;MD6wNFMyQCEQvF2= M3T4XHNCVkeHUh?=
CAL-51 MoXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;5TWM2OD1yLkCwN|I2KM7:TR?= NF7sOXNUSU6JRWK=
MCF7 NWPpTld{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUniVopHUUN3ME2wMlAxOzN3IN88US=> M2HLenNCVkeHUh?=
SK-HEP-1 NYGwc3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\LTWM2OD1yLkCwN|M3KM7:TR?= M1;GNXNCVkeHUh?=
LCLC-103H MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEC0N{DPxE1? NFvLT2FUSU6JRWK=
HMV-II NXn0bHp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r2fmlEPTB;MD6wNFQ1QSEQvF2= M2q0TnNCVkeHUh?=
MES-SA NUj5RYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqyT29tUUN3ME2wMlAxPDV{IN88US=> NETuUpRUSU6JRWK=
SK-LMS-1 NV;aV2ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\TNWlEPTB;MD6wNFQ2QCEQvF2= M33WRXNCVkeHUh?=
639-V MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTnTWM2OD1yLkCwOFg2KM7:TR?= MX;TRW5ITVJ?
SIG-M5 NEHRRY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPWbItKSzVyPUCuNFA1QDlizszN MkTEV2FPT0WU
LOUCY NYLjXo1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vpbmlEPTB;MD6wNFUxPSEQvF2= M4jLXnNCVkeHUh?=
HSC-2 M1nZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHBTHJKSzVyPUCuNFA2OThizszN NHvTXXhUSU6JRWK=
EW-13 M{XJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEC1NVgh|ryP MoLVV2FPT0WU
RT-112 NV[1SphYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEC1N|Uh|ryP NV3B[nN[W0GQR1XS
NKM-1 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEC1OFch|ryP NIfFS5JUSU6JRWK=
KYSE-180 NH\4SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEC1PFYh|ryP Ml;IV2FPT0WU
SW1783 NEPseXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nnPWlEPTB;MD6wNFU6OSEQvF2= MoHZV2FPT0WU
A431 Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID4eGhKSzVyPUCuNFA3ODdizszN MXfTRW5ITVJ?
SK-OV-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljtTWM2OD1yLkCwOlMh|ryP NU\vb3FyW0GQR1XS
RPMI-7951 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXEbodKSzVyPUCuNFA3OzFizszN MmXVV2FPT0WU
Capan-2 NGPlc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\rOHZKSzVyPUCuNFA3OzhizszN MkDlV2FPT0WU
HSC-3 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XUUmlEPTB;MD6wNFY1OSEQvF2= MX\TRW5ITVJ?
786-0 MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnMdVFKSzVyPUCuNFA3PjNizszN NXfJRYN4W0GQR1XS
Daoy M4XoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfxTWM2OD1yLkCwOlk2KM7:TR?= MkLJV2FPT0WU
KGN M3\oUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEC3NFMh|ryP M2H3SnNCVkeHUh?=
EW-16 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfwVotKSzVyPUCuNFA4PDlizszN MX3TRW5ITVJ?
EW-7 MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\TUI9KSzVyPUCuNFA4PTRizszN M2D4enNCVkeHUh?=
IGROV-1 NUTCZ4p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEC4NVQh|ryP MWXTRW5ITVJ?
8505C M2Oxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iyVmlEPTB;MD6wNFgzOSEQvF2= NHXaT3FUSU6JRWK=
RKO NGnPc4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHtTWM2OD1yLkCwPFI3KM7:TR?= NYnncYROW0GQR1XS
GDM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfBTWM2OD1yLkCwPFQh|ryP MojhV2FPT0WU
IST-MEL1 M2\1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDuTWM2OD1yLkCwPFUzKM7:TR?= NXjScGd6W0GQR1XS
RPMI-6666 NVjIfGtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEC4OVIh|ryP M{LQVnNCVkeHUh?=
SNG-M MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITl[IlKSzVyPUCuNFA5PTZizszN MmXYV2FPT0WU
KS-1 NUXhWY04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO2TWM2OD1yLkCwPFU6KM7:TR?= NFjlTXdUSU6JRWK=
RXF393 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DQXGlEPTB;MD6wNFg3KM7:TR?= NYTae4FFW0GQR1XS
CAL-12T MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Hud2lEPTB;MD6wNFkzOiEQvF2= NUXrOHFmW0GQR1XS
BFTC-905 M3;jU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUezPIQzUUN3ME2wMlAxQTN6IN88US=> NXLsWWRzW0GQR1XS
SK-MES-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEC5OFUh|ryP NEDzdXZUSU6JRWK=
BB30-HNC NXfuUmJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvLTWM2OD1yLkCwPVUzKM7:TR?= MojLV2FPT0WU
AN3-CA NWroW2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPZSZN[UUN3ME2wMlAyODF5IN88US=> NX3lfJg5W0GQR1XS
EFO-27 NILucXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;pXGlKSzVyPUCuNFExOTdizszN NYPVNZVKW0GQR1XS
G-401 NF;RPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:3TWM2OD1yLkCxNFI2KM7:TR?= M{\3dHNCVkeHUh?=
BPH-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTkS49[UUN3ME2wMlAyODNizszN NFHP[FJUSU6JRWK=
NCI-H727 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXPTWM2OD1yLkCxNFMh|ryP NIjTRndUSU6JRWK=
SNU-423 NGnCbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHhcotZUUN3ME2wMlAyODV|IN88US=> NYC0bW1XW0GQR1XS
KYSE-270 NIS1VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2xSXNKSzVyPUCuNFExPTlizszN NFPmZVNUSU6JRWK=
AGS Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonKTWM2OD1yLkCxNFYyKM7:TR?= NYnO[pdRW0GQR1XS
NCI-H2228 NIj5Vo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvIeYZKSzVyPUCuNFExPjRizszN M4rMdXNCVkeHUh?=
SW954 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Gzb2lEPTB;MD6wNVA4OSEQvF2= NWrtSFJsW0GQR1XS
769-P MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYSxPFg4UUN3ME2wMlAyODd|IN88US=> NVXXbmYyW0GQR1XS
BB49-HNC M2Hodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rqRmlEPTB;MD6wNVA4PyEQvF2= Mm\HV2FPT0WU
IA-LM NVXscFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEGwPFYh|ryP NYT3bGE2W0GQR1XS
NB69 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEGxNFIh|ryP MYTTRW5ITVJ?
C8166 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTnTWM2OD1yLkCxNVI6KM7:TR?= MX3TRW5ITVJ?
NCI-H1299 M1H2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3K5[2lEPTB;MD6wNVE2PCEQvF2= Mn3uV2FPT0WU
YKG-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzVbWJKSzVyPUCuNFEyPiEQvF2= MXvTRW5ITVJ?
PANC-03-27 M2G4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\1SWlvUUN3ME2wMlAyOTZ{IN88US=> M{TDXHNCVkeHUh?=
YT M2rwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfBTWM2OD1yLkCxNVc6KM7:TR?= MWHTRW5ITVJ?
CAL-85-1 MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2joZ2lEPTB;MD6wNVE6OiEQvF2= NVuxTnRKW0GQR1XS
GT3TKB NEj5OZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS2TWM2OD1yLkCxNlAzKM7:TR?= MnjaV2FPT0WU
BB65-RCC NVjTR5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;wbXNKSzVyPUCuNFEzODRizszN Mkf6V2FPT0WU
ES6 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEGyOlEh|ryP NVvEVIhJW0GQR1XS
MHH-ES-1 NIK5cllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7CTWM2OD1yLkCxNlY{KM7:TR?= MkDXV2FPT0WU
QIMR-WIL NGLWd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXFZXpKSzVyPUCuNFEzPjlizszN MY\TRW5ITVJ?
SNU-C2B MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HY[GlEPTB;MD6wNVI4OiEQvF2= MnLUV2FPT0WU
OCI-AML2 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Lz[WlEPTB;MD6wNVI5OSEQvF2= Mnj0V2FPT0WU
DU-145 NVjtZpFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPVWIFKSzVyPUCuNFEzQSEQvF2= M3\3S3NCVkeHUh?=
SW982 NXPjUHlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEGyPVMh|ryP MlH1V2FPT0WU
MFH-ino MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEGyPVMh|ryP MVLTRW5ITVJ?
A427 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fyR2lEPTB;MD6wNVI6QSEQvF2= MkDEV2FPT0WU
LCLC-97TM1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXexUFJEUUN3ME2wMlAyOyEQvF2= MYjTRW5ITVJ?
AM-38 NWrTVmRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO4T5dKSzVyPUCuNFE{ODJizszN Mn3YV2FPT0WU
K5 NX\SPHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GzRmlEPTB;MD6wNVMxQCEQvF2= NHH4enZUSU6JRWK=
T84 MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEGzN|Eh|ryP M1rhSHNCVkeHUh?=
TE-15 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEGzN|Yh|ryP M2XuUXNCVkeHUh?=
NCI-H460 NXLJeHJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEGzN|Yh|ryP NHPWfppUSU6JRWK=
NTERA-S-cl-D1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTTTWM2OD1yLkCxN|M6KM7:TR?= MUPTRW5ITVJ?
KYSE-450 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEGzOFkh|ryP Ml;xV2FPT0WU
H4 M{LUdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPnU5pKSzVyPUCuNFE{PjZizszN MXjTRW5ITVJ?
LC-2-ad MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTIUXFjUUN3ME2wMlAyOzdizszN NFPRSVVUSU6JRWK=
GAMG NGHJe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPKdmlqUUN3ME2wMlAyOzdzIN88US=> M2n4RXNCVkeHUh?=
TK10 NXGz[GpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\6TWM2OD1yLkCxN|gzKM7:TR?= M1rBW3NCVkeHUh?=
NCI-H2122 NEOwfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HQU2lEPTB;MD6wNVM5PCEQvF2= NGq0[JNUSU6JRWK=
KM12 NHjiVZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1O1O2lEPTB;MD6wNVM6QSEQvF2= M{C4fXNCVkeHUh?=
CAL-39 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEG0NkDPxE1? NXnSZlVEW0GQR1XS
RPMI-2650 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEG0N|Ih|ryP NWHHZlY1W0GQR1XS
KYSE-510 NH7EXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;ZfGlEPTB;MD6wNVQ1OiEQvF2= NELm[IFUSU6JRWK=
KALS-1 M2izTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi3ZWdKSzVyPUCuNFE1PjZizszN MXnTRW5ITVJ?
NCI-H1648 NWSwZ5BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\6PWlEPTB;MD6wNVQ6QSEQvF2= NYLH[XgzW0GQR1XS
ES4 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nWOGlEPTB;MD6wNVUxOiEQvF2= NUnEe21vW0GQR1XS
C-33-A MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEG1NFkh|ryP MmHYV2FPT0WU
MIA-PaCa-2 NHfsRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELoXFhKSzVyPUCuNFE2ODlizszN M1;4VnNCVkeHUh?=
Becker MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEG1NVQh|ryP NFjLcGRUSU6JRWK=
HOP-62 M{f6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PUTmlEPTB;MD6wNVU1OiEQvF2= MkXhV2FPT0WU
TE-1 NH34O5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjCRo5KSzVyPUCuNFE2QDFizszN MXTTRW5ITVJ?
KYSE-410 NHTX[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jWOWlEPTB;MD6wNVU5PiEQvF2= M1;TTnNCVkeHUh?=
NOS-1 Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zLbmlEPTB;MD6wNVU6OyEQvF2= NVnmenVQW0GQR1XS
MEL-HO NV[2VJRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEG2OFMh|ryP MUTTRW5ITVJ?
NCI-H1650 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Pq[mlEPTB;MD6wNVY1PiEQvF2= NIPBRZlUSU6JRWK=
VMRC-RCZ MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnOfI9zUUN3ME2wMlAyPjVzIN88US=> Mm\mV2FPT0WU
HuP-T3 NWHvZ|ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LiU2lEPTB;MD6wNVY2OyEQvF2= M1LjVnNCVkeHUh?=
ACN MlTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjPfJdKSzVyPUCuNFE3PTdizszN M{O0RXNCVkeHUh?=
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DMS-273 NFjxSnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDuSGJ4UUN3ME2wMlA{PDd7IN88US=> NF\zNWxUSU6JRWK=
22RV1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEO1NFch|ryP M1HQeXNCVkeHUh?=
ES8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEO1N|gh|ryP NGrveopUSU6JRWK=
KYSE-150 NF65bGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEO2NFgh|ryP NXLoT3dFW0GQR1XS
HCC1569 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\TTWM2OD1yLkCzOlA5KM7:TR?= NVjYbIg5W0GQR1XS
NB5 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P0TWlEPTB;MD6wN|YyOyEQvF2= NVryRXhRW0GQR1XS
G-402 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T1VGlEPTB;MD6wN|YyPCEQvF2= NYWzVYhOW0GQR1XS
NCI-H1693 NHPremZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEO2NVch|ryP NWLmb5VjW0GQR1XS
LB2241-RCC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF24[WZKSzVyPUCuNFM3PDJizszN NEHoZWpUSU6JRWK=
KP-4 M3rUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nC[GlEPTB;MD6wN|Y3OyEQvF2= NHPnfZZUSU6JRWK=
ML-2 NF7XTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3DdYxKSzVyPUCuNFM3PzFizszN MmDlV2FPT0WU
KU812 NW\OWpk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\z[phKSzVyPUCuNFM3QDRizszN MX3TRW5ITVJ?
LS-411N NGTXbWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf3NmNrUUN3ME2wMlA{PzNzIN88US=> M{Xoc3NCVkeHUh?=
OAW-42 NE\rc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\PNmlEPTB;MD6wN|c1PyEQvF2= NWPCN21qW0GQR1XS
HCC38 M4LNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrR[YdKSzVyPUCuNFM4PzFizszN Ml\hV2FPT0WU
Ca-Ski NIPLOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEO3PFQh|ryP MYLTRW5ITVJ?
Calu-3 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEO3PFkh|ryP NUDFUpBNW0GQR1XS
KYSE-70 NXj4bHd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEO4NVIh|ryP NGLmOGRUSU6JRWK=
D-392MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEO4OFIh|ryP NHfEdJNUSU6JRWK=
OVCAR-4 M{TqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHoWoY5UUN3ME2wMlA{QDV6IN88US=> NV;xdG9wW0GQR1XS
Detroit562 NVfNXXV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEO4O|Ih|ryP MnvRV2FPT0WU
HEL NGjYe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf6N2s4UUN3ME2wMlA{QDlzIN88US=> NEHGcIVUSU6JRWK=
MONO-MAC-6 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEO4PVMh|ryP NYLmRVBCW0GQR1XS
LoVo NF;qPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHVTWM2OD1yLkCzPVM{KM7:TR?= MmG5V2FPT0WU
U-2-OS NVnJfYRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLPSmRQUUN3ME2wMlA{QTN3IN88US=> M3PBZ3NCVkeHUh?=
A172 NW\hOlN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLFTWM2OD1yLkCzPVUh|ryP Mlv6V2FPT0WU
OCUB-M NITkR5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjJUVcxUUN3ME2wMlA{QTZzIN88US=> NInocndUSU6JRWK=
SW48 NIHoZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTTd4ZPUUN3ME2wMlA1ODNzIN88US=> M1zBenNCVkeHUh?=
HC-1 NEPJboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMESwOlkh|ryP NFnMWZFUSU6JRWK=
KOSC-2 NX7tOW1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMESxNUDPxE1? MULTRW5ITVJ?
HDLM-2 M1jD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnXTWM2OD1yLkC0NVE1KM7:TR?= MXzTRW5ITVJ?
CTV-1 M4DtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3SS5ZKSzVyPUCuNFQyOTZizszN NUfmXlVxW0GQR1XS
SH-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLJTWM2OD1yLkC0NVQyKM7:TR?= MmfWV2FPT0WU
SW756 NVXr[JhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMESxOVch|ryP NEnRRVFUSU6JRWK=
GCT NFG4cGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMESxOlEh|ryP Mo\sV2FPT0WU
CHL-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfuUlNRUUN3ME2wMlA1OTZ7IN88US=> MYXTRW5ITVJ?
LAMA-84 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq5SpdKSzVyPUCuNFQyPzFizszN Mn7VV2FPT0WU
LS-1034 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMESxPVEh|ryP NEP5[JRUSU6JRWK=
NCI-H358 NUHLPFRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX5RZBKSzVyPUCuNFQzOTJizszN MWDTRW5ITVJ?
NB13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fqNmlEPTB;MD6wOFIzPyEQvF2= M2nje3NCVkeHUh?=
TE-9 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjMS|hbUUN3ME2wMlA1OjN5IN88US=> NWjvPXBsW0GQR1XS
OE33 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTEfpQ4UUN3ME2wMlA1OjRzIN88US=> MlvHV2FPT0WU
CAL-120 NUDDV|VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXjUplzUUN3ME2wMlA1OjRzIN88US=> MXfTRW5ITVJ?
DJM-1 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf5TWM2OD1yLkC0NlczKM7:TR?= MXPTRW5ITVJ?
SK-MEL-24 M1TuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMESyPFMh|ryP M3;RcnNCVkeHUh?=
VA-ES-BJ NXrNb49xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDHRYFKSzVyPUCuNFQzQTJizszN NGmzVFJUSU6JRWK=
MMAC-SF MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HYTmlEPTB;MD6wOFI6PyEQvF2= M1PzTnNCVkeHUh?=
MZ7-mel M2PrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zyU2lEPTB;MD6wOFM{KM7:TR?= M{W5ZnNCVkeHUh?=
BxPC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXI[JRsUUN3ME2wMlA1OzRzIN88US=> NGHwRWRUSU6JRWK=
HT-29 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DuTGlEPTB;MD6wOFM2PyEQvF2= MWPTRW5ITVJ?
SK-MEL-30 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfFVGpZUUN3ME2wMlA1OzZ{IN88US=> MoHmV2FPT0WU
CAL-33 M1XRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjmbXpKSzVyPUCuNFQ{PzVizszN NHfJeHNUSU6JRWK=
COLO-680N NV3QVJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rSWWlEPTB;MD6wOFQxPyEQvF2= MkTmV2FPT0WU
NH-12 M1HBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeyNVdvUUN3ME2wMlA1PDRizszN MlW1V2FPT0WU
HCC1937 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMES0OVYh|ryP MX\TRW5ITVJ?
IMR-5 M{nHN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLsdYVKSzVyPUCuNFQ1QSEQvF2= NXXaPZpWW0GQR1XS
MC-CAR NXzYW4NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G0fWlEPTB;MD6wOFU3QSEQvF2= NF\IfZdUSU6JRWK=
NCI-H747 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPaTWM2OD1yLkC0OVch|ryP NUnCcHp6W0GQR1XS
NCI-H1792 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm4cGFKSzVyPUCuNFQ2QDFizszN M3\QVXNCVkeHUh?=
SW13 NGnOfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\vZXZKSzVyPUCuNFQ2QSEQvF2= M2HNRnNCVkeHUh?=
MLMA NXn1WpZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfQ[|dKSzVyPUCuNFQ3ODlizszN M3XOS3NCVkeHUh?=
U251 NVO3PZp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HiPGlEPTB;MD6wOFc3OyEQvF2= MkDUV2FPT0WU
U031 NILCOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEezSlNKSzVyPUCuNFQ4PzFizszN M3Hk[HNCVkeHUh?=
ME-180 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMES3PFIh|ryP M3nEdXNCVkeHUh?=
SK-MEL-3 M4O1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYftPFFGUUN3ME2wMlA1QDB{IN88US=> M1m5b3NCVkeHUh?=
MOLT-4 MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMES4NFMh|ryP NIeySZJUSU6JRWK=
PF-382 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLaTWM2OD1yLkC0PFI3KM7:TR?= MlToV2FPT0WU
NUGC-3 M4HPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMES4Nlch|ryP M2j3XHNCVkeHUh?=
NCI-H1417 NF34fFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHkTWM2OD1yLkC0PFkh|ryP NX;leGw2W0GQR1XS
COLO-205 NITOPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nRTGlEPTB;MD6wOFkyQSEQvF2= M3LYSnNCVkeHUh?=
TE-441-T NEnNPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMES5N{DPxE1? MX7TRW5ITVJ?
MKN1 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMES5N{DPxE1? Ml\WV2FPT0WU
UM-UC-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DlO2lEPTB;MD6wOFk2KM7:TR?= MVzTRW5ITVJ?
SF126 NWe5eGdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTYN4htUUN3ME2wMlA2ODFizszN M{HGbHNCVkeHUh?=
LB1047-RCC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TvWmlEPTB;MD6wOVA{OSEQvF2= MkK2V2FPT0WU
A253 MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqwV|NLUUN3ME2wMlA2ODV{IN88US=> Mo\pV2FPT0WU
NCI-H1963 M1;xNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfYOnVKSzVyPUCuNFUyPzZizszN MUnTRW5ITVJ?
VM-CUB-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTJeFhrUUN3ME2wMlA2OzFzIN88US=> NHvJe3lUSU6JRWK=
T-24 NG\hclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEWzPFQh|ryP MYPTRW5ITVJ?
K-562 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7FVYhMUUN3ME2wMlA2Ozh5IN88US=> NFWxOWVUSU6JRWK=
ARH-77 Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13GNWlEPTB;MD6wOVM6PSEQvF2= NWPRb|Z6W0GQR1XS
CA46 M1T2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jzcGlEPTB;MD6wOVQ{KM7:TR?= NFjMfWFUSU6JRWK=
HCC70 M2f1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEW0OVIh|ryP NHf5OmFUSU6JRWK=
ST486 NXLhWWw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T2T2lEPTB;MD6wOVUzPSEQvF2= MWjTRW5ITVJ?
COLO-741 MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzTWM2OD1yLkC1OVMyKM7:TR?= NYDDT5J6W0GQR1XS
SK-PN-DW NH\iO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LhOWlEPTB;MD6wOVU5QCEQvF2= NUjGNYhYW0GQR1XS
BL-41 NH;hSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESwVmtKSzVyPUCuNFU2QTZizszN M3\RNHNCVkeHUh?=
D-263MG NYXrOJZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Oz[mlEPTB;MD6wOVY5OyEQvF2= Ml\HV2FPT0WU
KE-37 NVvvRnlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEW2PFMh|ryP MnXQV2FPT0WU
LU-134-A MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;QTWM2OD1yLkC1O|E2KM7:TR?= NX3WUWZKW0GQR1XS
HCC2157 M4G5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEW3N|Mh|ryP MV\TRW5ITVJ?
GAK MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEW3N|Qh|ryP M3f2THNCVkeHUh?=
IST-SL2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEW3OFMh|ryP MX\TRW5ITVJ?
KMOE-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XuZ2lEPTB;MD6wOVc1QSEQvF2= M{TkUnNCVkeHUh?=
SW1573 M3rUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn2NoJHUUN3ME2wMlA2QDB{IN88US=> M{XNTnNCVkeHUh?=
SCC-9 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T3OWlEPTB;MD6wOVg4KM7:TR?= MYDTRW5ITVJ?
MDA-MB-361 MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ydIdoUUN3ME2wMlA2QDd{IN88US=> M2rnUnNCVkeHUh?=
BHT-101 NVHLWHdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEW4O|Yh|ryP NH7ocodUSU6JRWK=
NCI-H1770 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[yTWM2OD1yLkC1PFc6KM7:TR?= NH:yXWpUSU6JRWK=
UACC-893 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTGdWxKSzVyPUCuNFU5QTZizszN MmL4V2FPT0WU
NCI-H226 M{HNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljFTWM2OD1yLkC1PVg5KM7:TR?= MnnMV2FPT0WU
HLE Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HjUWlEPTB;MD6wOlA5OiEQvF2= NY\FOHJTW0GQR1XS
NCI-H1703 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfYWYxKSzVyPUCuNFYyPzhizszN M4HKdHNCVkeHUh?=
KURAMOCHI NXXQR4N7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwME[xPFkh|ryP MV3TRW5ITVJ?
RH-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDnTWM2OD1yLkC2NlMh|ryP NWXHe2hFW0GQR1XS
DSH1 NI\JbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwME[yO{DPxE1? MlKzV2FPT0WU
CAMA-1 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwME[zNFMh|ryP M4fueXNCVkeHUh?=
NCI-H1437 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[3O2lEPTB;MD6wOlMzQCEQvF2= MVjTRW5ITVJ?
HuP-T4 NHf6cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XvV2lEPTB;MD6wOlU5PiEQvF2= MVLTRW5ITVJ?
HCT-15 NH7HbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkixTWM2OD1yLkC2OVk4KM7:TR?= NU\wR49UW0GQR1XS
NCCIT NHT4Tm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwME[2NFQh|ryP M{DRZnNCVkeHUh?=
BOKU NXLQdZZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[yVlNUUUN3ME2wMlA3Pjd2IN88US=> M2HPOHNCVkeHUh?=
FADU MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TO[WlEPTB;MD6wOlc1PSEQvF2= NEHmV41USU6JRWK=
SUP-T1 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7rNIVKSzVyPUCuNFY4PiEQvF2= NXfzZlE{W0GQR1XS
L-363 M4Sybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\0TWM2OD1yLkC2PVAyKM7:TR?= NEnxeGxUSU6JRWK=
KNS-81-FD M1TRPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0R3Y3UUN3ME2wMlA3QTF6IN88US=> MkfxV2FPT0WU
SU-DHL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf2TWM2OD1yLkC2PVIh|ryP M4jBSXNCVkeHUh?=
HuH-7 NHLRd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV34cpZ6UUN3ME2wMlA4ODN3IN88US=> MnHRV2FPT0WU
BT-474 NIH4SJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TxSWlEPTB;MD6wO|A3OSEQvF2= NWHD[JBqW0GQR1XS
CAPAN-1 Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7r[o1KSzVyPUCuNFcyPDNizszN MUTTRW5ITVJ?
HEC-1 NV\PUpRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojKTWM2OD1yLkC3NVYyKM7:TR?= MlrkV2FPT0WU
NOMO-1 NWr5b3l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrzTWM2OD1yLkC3NVczKM7:TR?= MWfTRW5ITVJ?
KM-H2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrMZ5VpUUN3ME2wMlA4OjRzIN88US=> M4XNVXNCVkeHUh?=
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HuO-3N1 NUW2Zo1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;XTWM2OD1zLkizOFEzKM7:TR?= NUXz[|JHW0GQR1XS
NCI-H1793 NFi1[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn6TWM2OD1zLki3OVk{KM7:TR?= NXPHZ|VKW0GQR1XS
Caov-3 MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DtOWlEPTB;Mj6wNFYzPSEQvF2= M1;h[HNCVkeHUh?=
JAR NE\FSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHIWpJ6UUN3ME2yMlA4QTJizszN NYjpR2tqW0GQR1XS
SK-MEL-28 NFnNeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKyTWM2OD1{LkG4NFk5KM7:TR?= MYDTRW5ITVJ?
EM-2 NI[xdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\RenNEUUN3ME2yMlIxOjl|IN88US=> MYjTRW5ITVJ?
Mewo NV70dFhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\LeWlEPTB;Mj6yNlI3PSEQvF2= M2DZVnNCVkeHUh?=
NCI-H720 NHfLN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6xTVBQUUN3ME2yMlI3PTh3IN88US=> M1y0[nNCVkeHUh?=
CAL-54 M4r6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XpRWlEPTB;Mj6yOlc6PSEQvF2= NXK0bXV2W0GQR1XS
MC116 M2\heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SzeWlEPTB;Mj6zOlM6PyEQvF2= NFezSYxUSU6JRWK=
DG-75 NF7yXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jqb2lEPTB;Mj60PFU4PiEQvF2= NUOxdFJWW0GQR1XS
HCC1143 NFW2OmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD1XY81UUN3ME2yMlUxPjV6IN88US=> MlPYV2FPT0WU
FTC-133 NHf1SZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fJVmlEPTB;Mj61N|Y5QSEQvF2= M3nyS3NCVkeHUh?=
AsPC-1 MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\FeGNKSzVyPUKuOVM6OjlizszN M2DlNXNCVkeHUh?=
NCI-H889 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfaVWZmUUN3ME2yMlU3PzB4IN88US=> Ml7YV2FPT0WU
HT55 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\HTWM2OD1{Lk[yNFE6KM7:TR?= NX3XenF4W0GQR1XS
UMC-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLETWM2OD1{Lke4O|E2KM7:TR?= M1TiT3NCVkeHUh?=
P12-ICHIKAWA MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nuZWlEPTB;Mj64NlA1PiEQvF2= MmjrV2FPT0WU
HCC1395 M1njSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nGRmlEPTB;Mj65PFYxOiEQvF2= NW\YOlFVW0GQR1XS
D-283MED NGftfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTNwMUi5N|ch|ryP MkHaV2FPT0WU
COLO-800 M2DtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj3OGZKSzVyPUOuN|M5QTdizszN M{\UVXNCVkeHUh?=
MFM-223 NUDMcZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTNwM{[wPVch|ryP M4jzSHNCVkeHUh?=
TE-5 NGf4OpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LyfGlEPTB;ND61OlE1PyEQvF2= MVrTRW5ITVJ?
NCI-H209 NFTzbWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwN{i1O|Ih|ryP MWrTRW5ITVJ?
SiHa MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nz[GlEPTB;ND65OVIxOyEQvF2= M4jHe3NCVkeHUh?=
NCI-H1395 MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTVwMUC2N|Mh|ryP NGS1N3NUSU6JRWK=
A498 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG3NJpKSzVyPUWuNlEzPTFizszN NFvpPXBUSU6JRWK=
ES5 M2T3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LRfGlEPTB;NT62NVE4QCEQvF2= NYnlSZVLW0GQR1XS
MDA-MB-157 NX7MW2NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7Eb4M2UUN3ME21MlY3PDR|IN88US=> M4fP[3NCVkeHUh?=
NCI-H1623 NIPJNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrGb2ZKSzVyPUWuPFM2PTZizszN M2H0fXNCVkeHUh?=
RPMI-8866 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fxUmlEPTB;NT64OFc6OiEQvF2= MXHTRW5ITVJ?
LC-1F NFfLPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlThTWM2OD14LkC5NlkyKM7:TR?= NW\6S3MxW0GQR1XS
TCCSUP M2jqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq0TWM2OD14Lk[wN|Q6KM7:TR?= NUm4b2d4W0GQR1XS
TT MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS2bXU3UUN3ME24MlM{ODB7IN88US=> NXLEU5hHW0GQR1XS
NCI-H1838 NXnkV2hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDNTWM2OD16LkWxO|MyKM7:TR?= NHL2d|dUSU6JRWK=
NCI-H322M MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\UeW1KSzVyPUmuNVYzQDFizszN NXflXJlwW0GQR1XS
NCI-H187 NEX5T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTlwNUG4N|Uh|ryP MXHTRW5ITVJ?
SBC-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml70TWM2OD17LkmzOlU3KM7:TR?= MYHTRW5ITVJ?
SCC-3 M1TucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIezO3ZKSzVyPUGwMlU3PzlizszN NEDkeotUSU6JRWK=
SW948 MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe3dWdzUUN3ME2xNE44PTFzIN88US=> MlLIV2FPT0WU
CPC-N M{LiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[2NoluUUN3ME2xNU4xODdizszN M3ThVHNCVkeHUh?=
TGBC24TKB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPWNWNKSzVyPUGzMlUzQSEQvF2= M{X0fXNCVkeHUh?=
NCI-H2452 M{WxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknITWM2OD1zND63N{DPxE1? NYTwSIljW0GQR1XS
Hs-578-T MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITq[XlKSzVyPUG4MlU4PTlizszN M{ntNHNCVkeHUh?=
DV-90 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj0VldKSzVyPUG4Mlk6PDVizszN MX7TRW5ITVJ?
NCI-H1563 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fESmlEPTB;MUmuO|g5QCEQvF2= NXPxNZJDW0GQR1XS
SW780 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPZWoV[UUN3ME2yNU4yOzF6IN88US=> NUjBco9VW0GQR1XS
NCI-H345 M1naWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfVdIFKSzVyPUKxMlg4PzlizszN M1zwN3NCVkeHUh?=
LB771-HNC M{HaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXLcllKSzVyPUKyMlQ5OTNizszN NYrCfWNmW0GQR1XS
RT4 NV7OVWN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TubmlEPTB;MkOuN|I5OiEQvF2= M2jLNXNCVkeHUh?=
NCI-H82 NHvPb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPGfFVpUUN3ME2yN{42PTJ4IN88US=> M1TRNnNCVkeHUh?=
NCI-H524 NEfQW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rkRWlEPTB;MkSuN|gyOiEQvF2= M1TMenNCVkeHUh?=
SNU-C1 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnHTWM2OD1{ND65NVA2KM7:TR?= MnTyV2FPT0WU
NCI-SNU-16 MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD4TWM2OD12OD6zNVQzKM7:TR?= NVvM[ZNYW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; 

PubMed: 23993685     


Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein.

E-cadherin / Cleaved PARP / Bim; 

PubMed: 23993685     


Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein.

HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; 

PubMed: 24796583     


CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control.

CDK4 / HMGA2 ; 

PubMed: 26893968     


HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.

23993685 24796583 26893968
Growth inhibition assay
Cell viability; 

PubMed: 26893968     


Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed in three independent experiments.

26893968
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
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Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
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  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Drug: AUY922 Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Drug: AUY922|Drug: BYL719 Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1
NCT01484860 Terminated Drug: AUY922 Adenocarcinoma of the Pancreas|Metastatic Disease University Health Network Toronto|Novartis Pharmaceuticals January 2012 Phase 2
NCT01402401 Terminated Drug: AUY922 + Trastuzumab Advanced Gastric Cancer Novartis Pharmaceuticals|Novartis November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID