Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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Cited by 44 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK1TWM2OD1yLkCwNFEzPSEQvF2= NE\idHlUSU6JRWK=
MV-4-11 M{\BVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nScGlEPTB;MD6wNFA2PThizszN NWKzVpRvW0GQR1XS
NALM-6 NVvqXlhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvxfG86UUN3ME2wMlAxODh2MjFOwG0> MVXTRW5ITVJ?
HOS M1zWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTOWGhKSzVyPUCuNFAyOzhizszN MnHtV2FPT0WU
HT-144 NYrVNIQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nSUmlEPTB;MD6wNFE2PSEQvF2= M4roNHNCVkeHUh?=
SW1710 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fmPWlEPTB;MD6wNFE5PiEQvF2= NFzNSZJUSU6JRWK=
TE-8 NY\oSFJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMECyN|ch|ryP M2HYenNCVkeHUh?=
ES1 M1jVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm0fGJKSzVyPUCuNFAzPjZizszN NEHlU|NUSU6JRWK=
CCF-STTG1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n3W2lEPTB;MD6wNFI6PyEQvF2= NULoTohHW0GQR1XS
PSN1 NXm4O5RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXJRYlKSzVyPUCuNFA{OThizszN MlnqV2FPT0WU
CAL-51 M2rvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH6VIZKSzVyPUCuNFA{OjVizszN MlSyV2FPT0WU
MCF7 M{\FRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;oPWdKSzVyPUCuNFA{OzVizszN NFW3em5USU6JRWK=
SK-HEP-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMECzN|Yh|ryP M1rmcnNCVkeHUh?=
LCLC-103H MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPZ[ppKSzVyPUCuNFA1OyEQvF2= NGi3SZRUSU6JRWK=
HMV-II M2\qR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;hZnZKSzVyPUCuNFA1PDlizszN MmPEV2FPT0WU
MES-SA M2W3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e4dGlEPTB;MD6wNFQ2OiEQvF2= MVHTRW5ITVJ?
SK-LMS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDid5pzUUN3ME2wMlAxPDV6IN88US=> NVfj[ItxW0GQR1XS
639-V NVm1O5pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DoTWlEPTB;MD6wNFQ5PSEQvF2= MXHTRW5ITVJ?
SIG-M5 M4CwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuwXFZMUUN3ME2wMlAxPDh7IN88US=> MWTTRW5ITVJ?
LOUCY M3n5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXOR|V[UUN3ME2wMlAxPTB3IN88US=> MYDTRW5ITVJ?
HSC-2 NUDpO5JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjuTWM2OD1yLkCwOVE5KM7:TR?= NILzfYpUSU6JRWK=
EW-13 NEPGfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Twd2lEPTB;MD6wNFUyQCEQvF2= MV;TRW5ITVJ?
RT-112 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZRY8{UUN3ME2wMlAxPTN3IN88US=> MmLXV2FPT0WU
NKM-1 MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDMendKSzVyPUCuNFA2PDdizszN MXTTRW5ITVJ?
KYSE-180 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3NTWM2OD1yLkCwOVg3KM7:TR?= MkjwV2FPT0WU
SW1783 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEC1PVEh|ryP MXPTRW5ITVJ?
A431 M1viTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEC2NFch|ryP MlLxV2FPT0WU
SK-OV-3 M1nwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDkW4k2UUN3ME2wMlAxPjNizszN MUPTRW5ITVJ?
RPMI-7951 NGS5e4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTMTWM2OD1yLkCwOlMyKM7:TR?= MnvVV2FPT0WU
Capan-2 NIXv[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrJNllKSzVyPUCuNFA3OzhizszN NF3PXJhUSU6JRWK=
HSC-3 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\1TWM2OD1yLkCwOlQyKM7:TR?= M{nyXHNCVkeHUh?=
786-0 NX3PTZk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S3ZmlEPTB;MD6wNFY3OyEQvF2= M{mwS3NCVkeHUh?=
Daoy NVqzToVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3KT|NLUUN3ME2wMlAxPjl3IN88US=> M1nOTHNCVkeHUh?=
KGN NITVRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKzfYhSUUN3ME2wMlAxPzB|IN88US=> MWfTRW5ITVJ?
EW-16 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLmd|hKSzVyPUCuNFA4PDlizszN MYXTRW5ITVJ?
EW-7 NWnDd|FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfYPXBKSzVyPUCuNFA4PTRizszN MV;TRW5ITVJ?
IGROV-1 NFjCeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGU5kyUUN3ME2wMlAxQDF2IN88US=> NV35O3llW0GQR1XS
8505C MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzHbI5{UUN3ME2wMlAxQDJzIN88US=> M2H0XXNCVkeHUh?=
RKO MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrJ[HJKSzVyPUCuNFA5OjZizszN NIrCdVVUSU6JRWK=
GDM-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEC4OEDPxE1? NUnqfXo4W0GQR1XS
IST-MEL1 MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXWTWM2OD1yLkCwPFUzKM7:TR?= M2DOUHNCVkeHUh?=
RPMI-6666 M17uVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLW[5hDUUN3ME2wMlAxQDV{IN88US=> MlfiV2FPT0WU
SNG-M NIKzVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[5ZWlEPTB;MD6wNFg2PiEQvF2= M3T0N3NCVkeHUh?=
KS-1 M3WyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHNTWM2OD1yLkCwPFU6KM7:TR?= MoL1V2FPT0WU
RXF393 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTJ[mJvUUN3ME2wMlAxQDZizszN MX7TRW5ITVJ?
CAL-12T NFLSWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jOdWlEPTB;MD6wNFkzOiEQvF2= M2XUZnNCVkeHUh?=
BFTC-905 NY\xUXF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT0enBKSzVyPUCuNFA6OzhizszN M1;MWnNCVkeHUh?=
SK-MES-1 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;LTWM2OD1yLkCwPVQ2KM7:TR?= MVrTRW5ITVJ?
BB30-HNC NETxVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LmVmlEPTB;MD6wNFk2OiEQvF2= NFi2OXdUSU6JRWK=
AN3-CA NF\wW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEGwNVch|ryP MlG1V2FPT0WU
EFO-27 M4C1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\0d5ZKSzVyPUCuNFExOTdizszN M2rKbnNCVkeHUh?=
G-401 NFXFUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17w[GlEPTB;MD6wNVAzPSEQvF2= Mkm4V2FPT0WU
BPH-1 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TrRmlEPTB;MD6wNVA{KM7:TR?= MWTTRW5ITVJ?
NCI-H727 NFTMe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrNbodKSzVyPUCuNFExOyEQvF2= NITTTYtUSU6JRWK=
SNU-423 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X6S2lEPTB;MD6wNVA2OyEQvF2= NEPteJlUSU6JRWK=
KYSE-270 NWLiOGZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fUUGlEPTB;MD6wNVA2QSEQvF2= NGjC[o9USU6JRWK=
AGS MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTKWmV3UUN3ME2wMlAyODZzIN88US=> M4GxeXNCVkeHUh?=
NCI-H2228 M3vXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEGwOlQh|ryP NUnue2xQW0GQR1XS
SW954 NYC3R2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;3VmlEPTB;MD6wNVA4OSEQvF2= MlrmV2FPT0WU
769-P NVrP[WpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoryTWM2OD1yLkCxNFc{KM7:TR?= MV\TRW5ITVJ?
BB49-HNC MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrGZXlKSzVyPUCuNFExPzdizszN M3fhXXNCVkeHUh?=
IA-LM Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEGwPFYh|ryP MoXRV2FPT0WU
NB69 M123fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzGPIxKSzVyPUCuNFEyODJizszN NIH2Z|JUSU6JRWK=
C8166 NXf1SJJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnmZotKSzVyPUCuNFEyOjlizszN NGK3R3NUSU6JRWK=
NCI-H1299 NXK0Xoh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHDTWM2OD1yLkCxNVU1KM7:TR?= M{fpN3NCVkeHUh?=
YKG-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEGxOkDPxE1? NHH2UZRUSU6JRWK=
PANC-03-27 NFTjPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\mTWM2OD1yLkCxNVYzKM7:TR?= NEPqdYtUSU6JRWK=
YT NUXBRnV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zSTmlEPTB;MD6wNVE4QSEQvF2= MX\TRW5ITVJ?
CAL-85-1 M37qcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEGxPVIh|ryP NHHYfJBUSU6JRWK=
GT3TKB MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvhTIRkUUN3ME2wMlAyOjB{IN88US=> Mn;oV2FPT0WU
BB65-RCC NILQO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfITFl2UUN3ME2wMlAyOjB2IN88US=> M4nqO3NCVkeHUh?=
ES6 NWfSNZZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHwe25KSzVyPUCuNFEzPjFizszN MWrTRW5ITVJ?
MHH-ES-1 M2PqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEGyOlMh|ryP MnOxV2FPT0WU
QIMR-WIL MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33nRWlEPTB;MD6wNVI3QSEQvF2= MXLTRW5ITVJ?
SNU-C2B MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DnXmlEPTB;MD6wNVI4OiEQvF2= MlX2V2FPT0WU
OCI-AML2 NE\QWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrhTWM2OD1yLkCxNlgyKM7:TR?= NWHqTZQ5W0GQR1XS
DU-145 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEGyPUDPxE1? MnTvV2FPT0WU
SW982 NH7qZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M371TmlEPTB;MD6wNVI6OyEQvF2= M3e0SnNCVkeHUh?=
MFH-ino M4XsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOyRXZKSzVyPUCuNFEzQTNizszN MX;TRW5ITVJ?
A427 NEPRZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXITWM2OD1yLkCxNlk6KM7:TR?= M1;kbnNCVkeHUh?=
LCLC-97TM1 MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O4dGlEPTB;MD6wNVMh|ryP NUPEWW9UW0GQR1XS
AM-38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEGzNFIh|ryP NHW3PZNUSU6JRWK=
K5 NIXhVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK1UWJKSzVyPUCuNFE{ODhizszN M4m5NHNCVkeHUh?=
T84 M2r4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjGXZdKSzVyPUCuNFE{OzFizszN M{OwUHNCVkeHUh?=
TE-15 NXLkNpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfvTWM2OD1yLkCxN|M3KM7:TR?= MXXTRW5ITVJ?
NCI-H460 NI\5SmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDQO4NKSzVyPUCuNFE{OzZizszN NVXUNoc1W0GQR1XS
NTERA-S-cl-D1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPjdVRKSzVyPUCuNFE{OzlizszN M13QdHNCVkeHUh?=
KYSE-450 NVqxPXl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S2VmlEPTB;MD6wNVM1QSEQvF2= M33ETHNCVkeHUh?=
H4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:2cmlEPTB;MD6wNVM3PiEQvF2= MlTrV2FPT0WU
LC-2-ad NUHRUG1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrsVXRKSzVyPUCuNFE{PyEQvF2= NUPoWIhOW0GQR1XS
GAMG M{izOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHCR3hKSzVyPUCuNFE{PzFizszN MX;TRW5ITVJ?
TK10 NX7lPHVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHtTWM2OD1yLkCxN|gzKM7:TR?= NIXPR2RUSU6JRWK=
NCI-H2122 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDOd2FYUUN3ME2wMlAyOzh2IN88US=> NVr6elhYW0GQR1XS
KM12 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\CUGlEPTB;MD6wNVM6QSEQvF2= NFrBe4NUSU6JRWK=
CAL-39 M3q4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETBN4hKSzVyPUCuNFE1OiEQvF2= M3zIenNCVkeHUh?=
RPMI-2650 M1:ycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv4VWVKSzVyPUCuNFE1OzJizszN NEPqU4xUSU6JRWK=
KYSE-510 NXy2PHQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LvSmlEPTB;MD6wNVQ1OiEQvF2= MkX5V2FPT0WU
KALS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES1dodKSzVyPUCuNFE1PjZizszN MnfyV2FPT0WU
NCI-H1648 NV;Yd45{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfGcWxRUUN3ME2wMlAyPDl7IN88US=> Mn3DV2FPT0WU
ES4 NYPvVVRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEG1NFIh|ryP MlzJV2FPT0WU
C-33-A MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEG1NFkh|ryP NGruUXdUSU6JRWK=
MIA-PaCa-2 NUXaZ|ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEG1NFkh|ryP NXrrencyW0GQR1XS
Becker M{[3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\weWlEPTB;MD6wNVUyPCEQvF2= MX7TRW5ITVJ?
HOP-62 M{PDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEG1OFIh|ryP M{e3XnNCVkeHUh?=
TE-1 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ZUHBKSzVyPUCuNFE2QDFizszN MWDTRW5ITVJ?
KYSE-410 NWPaRmRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rQbWlEPTB;MD6wNVU5PiEQvF2= NHTVSppUSU6JRWK=
NOS-1 NIX6TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TpW2lEPTB;MD6wNVU6OyEQvF2= MWrTRW5ITVJ?
MEL-HO MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTrTWM2OD1yLkCxOlQ{KM7:TR?= NVjRcFhnW0GQR1XS
NCI-H1650 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEG2OFYh|ryP M4Xhc3NCVkeHUh?=
VMRC-RCZ NYTXOGtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\aTWM2OD1yLkCxOlUyKM7:TR?= M2G3cnNCVkeHUh?=
HuP-T3 NHvYO3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEG2OVMh|ryP MoHXV2FPT0WU
ACN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzWTWM2OD1yLkCxOlU4KM7:TR?= NFPjfphUSU6JRWK=
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SF268 M2PMS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37PW2lEPTB;MD6wN|QxOSEQvF2= MUjTRW5ITVJ?
BV-173 M{XsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\aTWM2OD1yLkCzOFI3KM7:TR?= MV\TRW5ITVJ?
DMS-273 NHfSbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW5ZXRUUUN3ME2wMlA{PDd7IN88US=> MYXTRW5ITVJ?
22RV1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[4dmlEPTB;MD6wN|UxPyEQvF2= NU\pV2R3W0GQR1XS
ES8 NYTGdZZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEO1N|gh|ryP NWfSbmpzW0GQR1XS
KYSE-150 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEO2NFgh|ryP NFLySFJUSU6JRWK=
HCC1569 NH7lSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHae3V4UUN3ME2wMlA{PjB6IN88US=> NY\vVm5xW0GQR1XS
NB5 NW\UcncyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrvfYtNUUN3ME2wMlA{PjF|IN88US=> MnPJV2FPT0WU
G-402 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT1XWFKSzVyPUCuNFM3OTRizszN NIrLdopUSU6JRWK=
NCI-H1693 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rkeGlEPTB;MD6wN|YyPyEQvF2= M3LG[HNCVkeHUh?=
LB2241-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPMb4hKSzVyPUCuNFM3PDJizszN MY\TRW5ITVJ?
KP-4 NHXvfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEO2OlMh|ryP NGTic3lUSU6JRWK=
ML-2 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G3e2lEPTB;MD6wN|Y4OSEQvF2= M1jjbXNCVkeHUh?=
KU812 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPWTWM2OD1yLkCzOlg1KM7:TR?= MnK3V2FPT0WU
LS-411N M{flWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\DPWhXUUN3ME2wMlA{PzNzIN88US=> MkLhV2FPT0WU
OAW-42 M4DuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEO3OFch|ryP MVHTRW5ITVJ?
HCC38 M2HNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e2NmlEPTB;MD6wN|c4OSEQvF2= NYPkWplEW0GQR1XS
Ca-Ski MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\MUG1KSzVyPUCuNFM4QDRizszN NH\yeHdUSU6JRWK=
Calu-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEO3PFkh|ryP NYXUVHNGW0GQR1XS
KYSE-70 NYnNSoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILIT5JKSzVyPUCuNFM5OTJizszN M1zB[HNCVkeHUh?=
D-392MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInVdphKSzVyPUCuNFM5PDJizszN NFPqO3JUSU6JRWK=
OVCAR-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG0dXpKSzVyPUCuNFM5PThizszN MWLTRW5ITVJ?
Detroit562 M{L5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH5TJVyUUN3ME2wMlA{QDd{IN88US=> MY\TRW5ITVJ?
HEL NX\2dIVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fUSWlEPTB;MD6wN|g6OSEQvF2= NX;4dJRrW0GQR1XS
MONO-MAC-6 NInSZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEO4PVMh|ryP MVjTRW5ITVJ?
LoVo Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{GxXGlEPTB;MD6wN|k{OyEQvF2= NU[wdol5W0GQR1XS
U-2-OS MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi0Sm4xUUN3ME2wMlA{QTN3IN88US=> MlzIV2FPT0WU
A172 NITMZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEO5OUDPxE1? MlX3V2FPT0WU
OCUB-M NYO1SVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjNTWM2OD1yLkCzPVYyKM7:TR?= MUnTRW5ITVJ?
SW48 NEK1W4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3EWplKSzVyPUCuNFQxOzFizszN MXvTRW5ITVJ?
HC-1 M2PMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDWUHFvUUN3ME2wMlA1ODZ7IN88US=> NG\4ZYlUSU6JRWK=
KOSC-2 NH32co5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm3bG1OUUN3ME2wMlA1OTFizszN NHHSOpdUSU6JRWK=
HDLM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7hTWM2OD1yLkC0NVE1KM7:TR?= NFvOOJVUSU6JRWK=
CTV-1 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvjTWM2OD1yLkC0NVE3KM7:TR?= NIq1NpVUSU6JRWK=
SH-4 M4HaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nSI5NUUN3ME2wMlA1OTRzIN88US=> M3jmU3NCVkeHUh?=
SW756 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjmbFhrUUN3ME2wMlA1OTV5IN88US=> NXXNXIMyW0GQR1XS
GCT MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;xUZdUUUN3ME2wMlA1OTZzIN88US=> NWPYSIFXW0GQR1XS
CHL-1 NVS0N5FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMESxOlkh|ryP M2L1WXNCVkeHUh?=
LAMA-84 NGLTcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL5TWM2OD1yLkC0NVcyKM7:TR?= NFjFUppUSU6JRWK=
LS-1034 NXfubZFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMESxPVEh|ryP MYjTRW5ITVJ?
NCI-H358 NFHrUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LpTmlEPTB;MD6wOFIyOiEQvF2= MmLhV2FPT0WU
NB13 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMESyNlch|ryP NYrDNYJbW0GQR1XS
TE-9 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMESyN|ch|ryP NFzlU|dUSU6JRWK=
OE33 M1PPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Tjd2lEPTB;MD6wOFI1OSEQvF2= M3f6enNCVkeHUh?=
CAL-120 M2jvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7N[WpKSzVyPUCuNFQzPDFizszN M4jwTXNCVkeHUh?=
DJM-1 NWnUeWpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm1TWM2OD1yLkC0NlczKM7:TR?= NX3u[WRqW0GQR1XS
SK-MEL-24 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u1[mlEPTB;MD6wOFI5OyEQvF2= M1LCdXNCVkeHUh?=
VA-ES-BJ NVe0ZllXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjhdGR[UUN3ME2wMlA1Ojl{IN88US=> NEXkUHlUSU6JRWK=
MMAC-SF MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC2TWM2OD1yLkC0Nlk4KM7:TR?= MljxV2FPT0WU
MZ7-mel M4f2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHVTWM2OD1yLkC0N|Mh|ryP NYW2d2dnW0GQR1XS
BxPC-3 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTpTWM2OD1yLkC0N|QyKM7:TR?= M4\BVHNCVkeHUh?=
HT-29 M{TlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfoWVBKSzVyPUCuNFQ{PTdizszN M3vnbnNCVkeHUh?=
SK-MEL-30 NHK4dGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMESzOlIh|ryP NHTyWJdUSU6JRWK=
CAL-33 M2LUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjMe2NKSzVyPUCuNFQ{PzVizszN MW\TRW5ITVJ?
COLO-680N NV\hS4NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fYWGlEPTB;MD6wOFQxPyEQvF2= MlrnV2FPT0WU
NH-12 NIruU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnxToJ[UUN3ME2wMlA1PDRizszN NV\CTGljW0GQR1XS
HCC1937 M1nad2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u2b2lEPTB;MD6wOFQ2PiEQvF2= MX;TRW5ITVJ?
IMR-5 NGTnUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMES0PUDPxE1? M2nsVnNCVkeHUh?=
MC-CAR NVPYc3hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfwNlBjUUN3ME2wMlA1PTZ7IN88US=> NWj6UIJKW0GQR1XS
NCI-H747 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfiTWM2OD1yLkC0OVch|ryP Mn;NV2FPT0WU
NCI-H1792 NFzYXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXNbYFKSzVyPUCuNFQ2QDFizszN MXnTRW5ITVJ?
SW13 NHOwNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXLbINKSzVyPUCuNFQ2QSEQvF2= M1XQRnNCVkeHUh?=
MLMA NED1d|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrNTo1KSzVyPUCuNFQ3ODlizszN M3fyXXNCVkeHUh?=
U251 M{fxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX21UoNuUUN3ME2wMlA1PzZ|IN88US=> MojpV2FPT0WU
U031 M1LNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj2NmdKSzVyPUCuNFQ4PzFizszN M{PGenNCVkeHUh?=
ME-180 NHfoWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMES3PFIh|ryP NIXwSHdUSU6JRWK=
SK-MEL-3 NVjtS4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMES4NFIh|ryP MkjzV2FPT0WU
MOLT-4 M{Themdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr4RmxJUUN3ME2wMlA1QDB|IN88US=> MYfTRW5ITVJ?
PF-382 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTHfXlKSzVyPUCuNFQ5OjZizszN M1z1dXNCVkeHUh?=
NUGC-3 MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G3T2lEPTB;MD6wOFgzPyEQvF2= M3vMR3NCVkeHUh?=
NCI-H1417 M4D3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jpS2lEPTB;MD6wOFg6KM7:TR?= Mo\IV2FPT0WU
COLO-205 NVn0dYpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrKcmdKSzVyPUCuNFQ6OTlizszN NFnDbnlUSU6JRWK=
TE-441-T Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe4TIxFUUN3ME2wMlA1QTNizszN NV[5d295W0GQR1XS
MKN1 M4nTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPj[ldKSzVyPUCuNFQ6OyEQvF2= MXfTRW5ITVJ?
UM-UC-3 NUTQbZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHi[It5UUN3ME2wMlA1QTVizszN M4jtW3NCVkeHUh?=
SF126 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O0N2lEPTB;MD6wOVAyKM7:TR?= M2TydHNCVkeHUh?=
LB1047-RCC M3[zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH1TWM2OD1yLkC1NFMyKM7:TR?= NW\UU|czW0GQR1XS
A253 NXjhRWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n4[GlEPTB;MD6wOVA2OiEQvF2= NFPUUVdUSU6JRWK=
NCI-H1963 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX2cJhKSzVyPUCuNFUyPzZizszN NFW5XVZUSU6JRWK=
VM-CUB-1 NHv2ZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEWzNVEh|ryP MYnTRW5ITVJ?
T-24 M2ThSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3MZodKSzVyPUCuNFU{QDRizszN M3fkZXNCVkeHUh?=
K-562 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXuPWtKSzVyPUCuNFU{QDdizszN M{jIVXNCVkeHUh?=
ARH-77 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXkTWM2OD1yLkC1N|k2KM7:TR?= M4XXeXNCVkeHUh?=
CA46 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEW0N{DPxE1? MXvTRW5ITVJ?
HCC70 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\EeGlEPTB;MD6wOVQ2OiEQvF2= M3rJVXNCVkeHUh?=
ST486 NV6wWWY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rFcmlEPTB;MD6wOVUzPSEQvF2= MUPTRW5ITVJ?
COLO-741 NIfvPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPIfYpDUUN3ME2wMlA2PTNzIN88US=> NUj6fFVsW0GQR1XS
SK-PN-DW NGm3SlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPFe2hKSzVyPUCuNFU2QDhizszN NFexUY9USU6JRWK=
BL-41 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fNdWlEPTB;MD6wOVU6PiEQvF2= NYDEb3R4W0GQR1XS
D-263MG MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEW2PFMh|ryP MkjRV2FPT0WU
KE-37 NWXnb5FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fGcGlEPTB;MD6wOVY5OyEQvF2= NYjifpdyW0GQR1XS
LU-134-A M3nBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvubZBKSzVyPUCuNFU4OTVizszN M3;TUHNCVkeHUh?=
HCC2157 NHTZbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorHTWM2OD1yLkC1O|M{KM7:TR?= M4\Pd3NCVkeHUh?=
GAK NWTXelQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7ZTWM2OD1yLkC1O|M1KM7:TR?= NH\kbJVUSU6JRWK=
IST-SL2 MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TUXWlEPTB;MD6wOVc1OyEQvF2= MkSwV2FPT0WU
KMOE-2 NH;oe4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEW3OFkh|ryP MYXTRW5ITVJ?
SW1573 M1fRS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\OdWlEPTB;MD6wOVgxOiEQvF2= MnTPV2FPT0WU
SCC-9 NUixV3lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEW4O{DPxE1? MX3TRW5ITVJ?
MDA-MB-361 M{nJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH4TWM2OD1yLkC1PFczKM7:TR?= NETUdoJUSU6JRWK=
BHT-101 NVPCSHV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEW4O|Yh|ryP MYnTRW5ITVJ?
NCI-H1770 M4P5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD1yLkC1PFc6KM7:TR?= NYX0fVhEW0GQR1XS
UACC-893 NES4NmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYflV5QzUUN3ME2wMlA2QDl4IN88US=> MUHTRW5ITVJ?
NCI-H226 NHzCS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEW5PFgh|ryP M1qzcXNCVkeHUh?=
HLE M2DXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vXNGlEPTB;MD6wOlA5OiEQvF2= MW\TRW5ITVJ?
NCI-H1703 NIDXc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXXTWM2OD1yLkC2NVc5KM7:TR?= Mlf5V2FPT0WU
KURAMOCHI NIPxbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli3TWM2OD1yLkC2NVg6KM7:TR?= Mkj4V2FPT0WU
RH-1 NFHtWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HyOGlEPTB;MD6wOlI{KM7:TR?= M4LRdnNCVkeHUh?=
DSH1 NVPvZnNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnWVW9KSzVyPUCuNFYzPyEQvF2= NGTMO25USU6JRWK=
CAMA-1 NVTtRYJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr4TWM2OD1yLkC2N|A{KM7:TR?= NGH3c2ZUSU6JRWK=
NCI-H1437 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[zNlgh|ryP MXHTRW5ITVJ?
HuP-T4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jqfmlEPTB;MD6wOlU5PiEQvF2= MUDTRW5ITVJ?
HCT-15 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwME[1PVch|ryP M{nCUnNCVkeHUh?=
NCCIT MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLabGUzUUN3ME2wMlA3PjB2IN88US=> NFfqc3hUSU6JRWK=
BOKU NW\DT|VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nrcGlEPTB;MD6wOlY4PCEQvF2= NInvcYJUSU6JRWK=
FADU MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37RPWlEPTB;MD6wOlc1PSEQvF2= MWfTRW5ITVJ?
SUP-T1 NHT6SoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwME[3OkDPxE1? NWD6UZdJW0GQR1XS
L-363 NEPEU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Dd5lOUUN3ME2wMlA3QTBzIN88US=> NH\XTYlUSU6JRWK=
KNS-81-FD NXPvWnZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnoTWM2OD1yLkC2PVE5KM7:TR?= NUf1fYhnW0GQR1XS
SU-DHL-1 M4TXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S0[2lEPTB;MD6wOlkzKM7:TR?= NVXQW|VYW0GQR1XS
HuH-7 NUX1fHRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEewN|Uh|ryP NEGzXXNUSU6JRWK=
BT-474 NV;EOFRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrETWM2OD1yLkC3NFYyKM7:TR?= MVfTRW5ITVJ?
CAPAN-1 NIr1eXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nufGlEPTB;MD6wO|E1OyEQvF2= NHW1WlNUSU6JRWK=
HEC-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHziXndKSzVyPUCuNFcyPjFizszN MX7TRW5ITVJ?
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HCC1187 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnsTWM2OD1zLkW1OVIzKM7:TR?= NUT1fHg{W0GQR1XS
EoL-1-cell M{\HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwNUi4PFkh|ryP NVnwe|hUW0GQR1XS
HuO-3N1 M{\4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jke2lEPTB;MT64N|QyOiEQvF2= M2PaTXNCVkeHUh?=
NCI-H1793 MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwOEe1PVMh|ryP NFnodo5USU6JRWK=
Caov-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJwMEC2NlUh|ryP NHGyd5ZUSU6JRWK=
JAR M4fIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nJeGlEPTB;Mj6wO|kzKM7:TR?= MlLJV2FPT0WU
SK-MEL-28 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMUiwPVgh|ryP NX3RRZFYW0GQR1XS
EM-2 NE\TbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjQTWM2OD1{LkKwNlk{KM7:TR?= MkHmV2FPT0WU
Mewo M1P2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy4[ZZZUUN3ME2yMlIzOjZ3IN88US=> NIjRN5VUSU6JRWK=
NCI-H720 NELEemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvBUJJHUUN3ME2yMlI3PTh3IN88US=> M1fpbXNCVkeHUh?=
CAL-54 M1vtemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLGTWM2OD1{LkK2O|k2KM7:TR?= NH;C[5lUSU6JRWK=
MC116 NUXFSploT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzXTWM2OD1{LkO2N|k4KM7:TR?= NUjuXWw5W0GQR1XS
DG-75 NHfzeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn5TItKSzVyPUKuOFg2PzZizszN M3y0ZXNCVkeHUh?=
HCC1143 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwNUC2OVgh|ryP NVPvdY1qW0GQR1XS
FTC-133 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ntUmlEPTB;Mj61N|Y5QSEQvF2= M2W5eXNCVkeHUh?=
AsPC-1 NXnROHViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfPeINKSzVyPUKuOVM6OjlizszN NXnEcHYxW0GQR1XS
NCI-H889 NHHPSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13PSGlEPTB;Mj61OlcxPiEQvF2= NYmwfoQ4W0GQR1XS
HT55 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi2OFZ1UUN3ME2yMlYzODF7IN88US=> M3:zfHNCVkeHUh?=
UMC-11 NXn1[Y9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwN{i3NVUh|ryP M4jUVnNCVkeHUh?=
P12-ICHIKAWA Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLQOpRMUUN3ME2yMlgzODR4IN88US=> MXzTRW5ITVJ?
HCC1395 MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJwOUi2NFIh|ryP NHrycI1USU6JRWK=
D-283MED M4e3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW0O21KSzVyPUOuNVg6OzdizszN NU\r[YxuW0GQR1XS
COLO-800 M3LZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rSXGlEPTB;Mz6zN|g6PyEQvF2= MkHnV2FPT0WU
MFM-223 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNXmlEPTB;Mz6zOlA6PyEQvF2= M1PVdXNCVkeHUh?=
TE-5 M2XSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7wUIZ2UUN3ME20MlU3OTR5IN88US=> M{ewb3NCVkeHUh?=
NCI-H209 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluxTWM2OD12Lke4OVczKM7:TR?= M1zBcnNCVkeHUh?=
SiHa NIewZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Xoe2lEPTB;ND65OVIxOyEQvF2= M4\CdHNCVkeHUh?=
NCI-H1395 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrYNm9mUUN3ME21MlExPjN|IN88US=> NXvablczW0GQR1XS
A498 NIiz[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\TfYxEUUN3ME21MlIyOjVzIN88US=> NWTBeVl1W0GQR1XS
ES5 NID2WoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPJWHJKSzVyPUWuOlEyPzhizszN NX;L[mt1W0GQR1XS
MDA-MB-157 NWjMPGpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTVwNk[0OFMh|ryP M1vUdHNCVkeHUh?=
NCI-H1623 NUP2WXROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPTTWM2OD13LkizOVU3KM7:TR?= MV\TRW5ITVJ?
RPMI-8866 NFXE[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\HbYdlUUN3ME21Mlg1Pzl{IN88US=> NXHBV4d[W0GQR1XS
LC-1F M2HU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml76TWM2OD14LkC5NlkyKM7:TR?= NEfi[nZUSU6JRWK=
TCCSUP M333PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTT[IhCUUN3ME22MlYxOzR7IN88US=> MUTTRW5ITVJ?
TT MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS3TWM2OD16LkOzNFA6KM7:TR?= Mn3vV2FPT0WU
NCI-H1838 NWHyWXQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRThwNUG3N|Eh|ryP M4\QXHNCVkeHUh?=
NCI-H322M M2XPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX3TWM2OD17LkG2NlgyKM7:TR?= NULIXI93W0GQR1XS
NCI-H187 M3rFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTlwNUG4N|Uh|ryP MlTJV2FPT0WU
SBC-1 NXvjRVVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjDS4w{UUN3ME25Mlk{PjV4IN88US=> NHvMOnZUSU6JRWK=
SCC-3 NUC5[FJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LzZ2lEPTB;MUCuOVY4QSEQvF2= NU[4VmlyW0GQR1XS
SW948 NYj4SZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;aW25uUUN3ME2xNE44PTFzIN88US=> Ml30V2FPT0WU
CPC-N MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFzLkCwO{DPxE1? NIDFcIRUSU6JRWK=
TGBC24TKB NV;0N|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF|LkWyPUDPxE1? NIjCR3pUSU6JRWK=
NCI-H2452 NYPvSHNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ftcGlEPTB;MUSuO|Mh|ryP NIm0do5USU6JRWK=
Hs-578-T M3Ple2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTF6LkW3OVkh|ryP M3;PcHNCVkeHUh?=
DV-90 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF6Lkm5OFUh|ryP NXXqcGw5W0GQR1XS
NCI-H1563 NUC3V2pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnNTWM2OD1zOT63PFg5KM7:TR?= MWrTRW5ITVJ?
SW780 M4Ht[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nmRmlEPTB;MkGuNVMyQCEQvF2= Mnn5V2FPT0WU
NCI-H345 M4TY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfmcYhnUUN3ME2yNU45Pzd7IN88US=> M3zTenNCVkeHUh?=
LB771-HNC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLMTWM2OD1{Mj60PFE{KM7:TR?= MV7TRW5ITVJ?
RT4 NXyxVoxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojsTWM2OD1{Mz6zNlgzKM7:TR?= M13TdXNCVkeHUh?=
NCI-H82 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljoTWM2OD1{Mz61OVI3KM7:TR?= M2GzUHNCVkeHUh?=
NCI-H524 M{ThNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjUTWM2OD1{ND6zPFEzKM7:TR?= MljWV2FPT0WU
SNU-C1 MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LQNWlEPTB;MkSuPVExPSEQvF2= MVnTRW5ITVJ?
NCI-SNU-16 NFXLdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzhWppKSzVyPUS4MlMyPDJizszN M1rRZXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; 

PubMed: 23993685     


Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein.

E-cadherin / Cleaved PARP / Bim; 

PubMed: 23993685     


Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein.

HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; 

PubMed: 24796583     


CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control.

CDK4 / HMGA2 ; 

PubMed: 26893968     


HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.

23993685 24796583 26893968
Growth inhibition assay
Cell viability; 

PubMed: 26893968     


Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed in three independent experiments.

26893968
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Drug: AUY922 Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Drug: AUY922|Drug: BYL719 Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1
NCT01484860 Terminated Drug: AUY922 Adenocarcinoma of the Pancreas|Metastatic Disease University Health Network Toronto|Novartis Pharmaceuticals January 2012 Phase 2
NCT01402401 Terminated Drug: AUY922 + Trastuzumab Advanced Gastric Cancer Novartis Pharmaceuticals|Novartis November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID