Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 25 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778 ( click the link to review the publication )

Mol Cancer, 2011, 10:125

PubMed: 21962244 ( click the link to review the publication )

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418 ( click the link to review the publication )

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685 ( click the link to review the publication )

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393 ( click the link to review the publication )
J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909 ( click the link to review the publication )

PLoS One, 2014, 9(12):e114506

PubMed: 25503774 ( click the link to review the publication )

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466 ( click the link to review the publication )

Sci Rep, 2017, 7(1):201

PubMed: 28298630 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175 ( click the link to review the publication )
American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed: ( click the link to review the publication )

3 Customer Reviews

U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.
Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922 (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LUbWlEPTB;MD6wNFAyOjVizszN	NHPEem5USU6JRWK=
MV-4-11	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknZTWM2OD1yLkCwNFU2QCEQvF2=	M36zbnNCVkeHUh?=
NALM-6	NXPpVYhTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXXTWM2OD1yLkCwNFg1OiEQvF2=	MVvTRW5ITVJ?
HOS	NWD5PIQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTBwMECxN\|gh\|ryP	NGe2OpRUSU6JRWK=
HT-144	NXXQd4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrhdW1KSzVyPUCuNFAyPTVizszN	NUjoW3o5W0GQR1XS
SW1710	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEL6SolKSzVyPUCuNFAyQDZizszN	MUfTRW5ITVJ?
TE-8	NF7RPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1e5dmlEPTB;MD6wNFI{PyEQvF2=	NVj2ZlkyW0GQR1XS
ES1	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Moi0TWM2OD1yLkCwNlY3KM7:TR?=	MYnTRW5ITVJ?
CCF-STTG1	M2jsPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYH4SmJiUUN3ME2wMlAxOjl5IN88US=>	M4\wTnNCVkeHUh?=
PSN1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFLOcIRKSzVyPUCuNFA{OThizszN	M2PMeXNCVkeHUh?=
CAL-51	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4HUU2lEPTB;MD6wNFMzPSEQvF2=	MUjTRW5ITVJ?
MCF7	NEPJ[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmewTWM2OD1yLkCwN\|M2KM7:TR?=	MnXWV2FPT0WU
SK-HEP-1	NFfjTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEfjNYVKSzVyPUCuNFA{OzZizszN	NEXpdXhUSU6JRWK=
LCLC-103H	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUTHXYJxUUN3ME2wMlAxPDNizszN	MnXBV2FPT0WU
HMV-II	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVGxXJdxUUN3ME2wMlAxPDR7IN88US=>	NGfuXGlUSU6JRWK=
MES-SA	NX;GUYVOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3jWdGlEPTB;MD6wNFQ2OiEQvF2=	M2C1bXNCVkeHUh?=
SK-LMS-1	MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTBwMEC0OVgh\|ryP	NXTBUGdJW0GQR1XS
639-V	NISyWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrhTWM2OD1yLkCwOFg2KM7:TR?=	Mm\LV2FPT0WU
SIG-M5	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHpTWM2OD1yLkCwOFg6KM7:TR?=	M1\jUHNCVkeHUh?=
LOUCY	NVWyVm5oT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlywTWM2OD1yLkCwOVA2KM7:TR?=	M{[wbnNCVkeHUh?=
HSC-2	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPnXYtjUUN3ME2wMlAxPTF6IN88US=>	M37kW3NCVkeHUh?=
EW-13	MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEnMdmVKSzVyPUCuNFA2OThizszN	M1;WNXNCVkeHUh?=
RT-112	M33QeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrGbIpKSzVyPUCuNFA2OzVizszN	M3zVSnNCVkeHUh?=
NKM-1	M3nsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGLadpJKSzVyPUCuNFA2PDdizszN	MYTTRW5ITVJ?
KYSE-180	NFfUcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX60[XNKUUN3ME2wMlAxPTh4IN88US=>	MUPTRW5ITVJ?
SW1783	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;3VmlEPTB;MD6wNFU6OSEQvF2=	MX;TRW5ITVJ?
A431	NVu1XIp[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXPJR\|UxRTBwMEC2NFch\|ryP	M2PEZXNCVkeHUh?=
SK-OV-3	MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYLZNVRqUUN3ME2wMlAxPjNizszN	M1nwUnNCVkeHUh?=
RPMI-7951	MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\6bGlEPTB;MD6wNFY{OSEQvF2=	M1vxTnNCVkeHUh?=
Capan-2	MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mly4TWM2OD1yLkCwOlM5KM7:TR?=	M1j0OXNCVkeHUh?=
HSC-3	NYjZPHlwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrTSmdKSzVyPUCuNFA3PDFizszN	MXHTRW5ITVJ?
786-0	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXftfGNMUUN3ME2wMlAxPjZ\|IN88US=>	NGLPZZNUSU6JRWK=
Daoy	M3PoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{\XSGlEPTB;MD6wNFY6PSEQvF2=	NUnPV2xmW0GQR1XS
KGN	NIraWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTBwMEC3NFMh\|ryP	NYjEN2ZZW0GQR1XS
EW-16	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHG4eFBKSzVyPUCuNFA4PDlizszN	M{\KcnNCVkeHUh?=
EW-7	NWrKU\|BQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYHJR\|UxRTBwMEC3OVQh\|ryP	MYXTRW5ITVJ?
IGROV-1	Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TOSWlEPTB;MD6wNFgyPCEQvF2=	MYLTRW5ITVJ?
8505C	NWLnNHE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\NcWhKSzVyPUCuNFA5OjFizszN	M3T4Z3NCVkeHUh?=
RKO	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTxTWM2OD1yLkCwPFI3KM7:TR?=	MnfRV2FPT0WU
GDM-1	NWrnSVVRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTBwMEC4OEDPxE1?	M1;3V3NCVkeHUh?=
IST-MEL1	MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rxNGlEPTB;MD6wNFg2OiEQvF2=	NGrSdXBUSU6JRWK=
RPMI-6666	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXvvboUzUUN3ME2wMlAxQDV{IN88US=>	NELCVllUSU6JRWK=
SNG-M	MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFLpWmZKSzVyPUCuNFA5PTZizszN	NHPvWIFUSU6JRWK=
KS-1	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWnJR\|UxRTBwMEC4OVkh\|ryP	MmPqV2FPT0WU
RXF393	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorzTWM2OD1yLkCwPFYh\|ryP	MlLSV2FPT0WU
CAL-12T	M4TORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVLJR\|UxRTBwMEC5NlIh\|ryP	Mn;RV2FPT0WU
BFTC-905	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHP2[ItKSzVyPUCuNFA6OzhizszN	MUjTRW5ITVJ?
SK-MES-1	M3fKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NULZcox3UUN3ME2wMlAxQTR3IN88US=>	MYTTRW5ITVJ?
BB30-HNC	Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3m3SmlEPTB;MD6wNFk2OiEQvF2=	Mkn6V2FPT0WU
AN3-CA	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwMEGwNVch\|ryP	NYC5TJVXW0GQR1XS
EFO-27	NILuRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXexW5ZJUUN3ME2wMlAyODF5IN88US=>	NGTme4RUSU6JRWK=
G-401	NEPUNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTBwMEGwNlUh\|ryP	NVPJRopsW0GQR1XS
BPH-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTBwMEGwN{DPxE1?	MmrDV2FPT0WU
NCI-H727	NFHGdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPtTWM2OD1yLkCxNFMh\|ryP	NWrLfGJyW0GQR1XS
SNU-423	M3HrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LlXWlEPTB;MD6wNVA2OyEQvF2=	NXfFdYJ3W0GQR1XS
KYSE-270	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkjUTWM2OD1yLkCxNFU6KM7:TR?=	Mo\xV2FPT0WU
AGS	NEH1c3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIX0SZlKSzVyPUCuNFExPjFizszN	MnPCV2FPT0WU
NCI-H2228	NFfzdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjKd28yUUN3ME2wMlAyODZ2IN88US=>	M1P4WXNCVkeHUh?=
SW954	NYj5TGlsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2DQZ2lEPTB;MD6wNVA4OSEQvF2=	MXrTRW5ITVJ?
769-P	NEDa[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFP4cXpKSzVyPUCuNFExPzNizszN	NY\rXId6W0GQR1XS
BB49-HNC	M4XlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2jw[mlEPTB;MD6wNVA4PyEQvF2=	MYrTRW5ITVJ?
IA-LM	M4nwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fZW2lEPTB;MD6wNVA5PiEQvF2=	M2LPRXNCVkeHUh?=
NB69	NIPQdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3rRZ2lEPTB;MD6wNVExOiEQvF2=	M2LOTXNCVkeHUh?=
C8166	NYG1UY1vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlL3TWM2OD1yLkCxNVI6KM7:TR?=	MWnTRW5ITVJ?
NCI-H1299	NWS3dFhWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFLEcplKSzVyPUCuNFEyPTRizszN	M{HXVXNCVkeHUh?=
YKG-1	M13XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTYTWM2OD1yLkCxNVYh\|ryP	NF3J[HJUSU6JRWK=
PANC-03-27	M4DsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTBwMEGxOlIh\|ryP	MnTYV2FPT0WU
YT	M3GzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTBwMEGxO\|kh\|ryP	MkjXV2FPT0WU
CAL-85-1	M3PkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{K4WWlEPTB;MD6wNVE6OiEQvF2=	NVL6UlhxW0GQR1XS
GT3TKB	NVfQTGZrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NULZdHFnUUN3ME2wMlAyOjB{IN88US=>	NEHEV3pUSU6JRWK=
BB65-RCC	NUPxdXdlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrlPFZKSzVyPUCuNFEzODRizszN	NH\K[VlUSU6JRWK=
ES6	NF\Lb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;FXpRXUUN3ME2wMlAyOjZzIN88US=>	NXPpUWVYW0GQR1XS
MHH-ES-1	NWrldm5xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{PQcWlEPTB;MD6wNVI3OyEQvF2=	MUTTRW5ITVJ?
QIMR-WIL	M4f1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4W4VGlEPTB;MD6wNVI3QSEQvF2=	NILtfYpUSU6JRWK=
SNU-C2B	M4DqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPGTWM2OD1yLkCxNlczKM7:TR?=	NEO0U3JUSU6JRWK=
OCI-AML2	M4f0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTBwMEGyPFEh\|ryP	MVjTRW5ITVJ?
DU-145	Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTBwMEGyPUDPxE1?	MUDTRW5ITVJ?
SW982	NV7zOXNST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHLHc4xKSzVyPUCuNFEzQTNizszN	MV;TRW5ITVJ?
MFH-ino	Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXL1U5JDUUN3ME2wMlAyOjl\|IN88US=>	NVTVS4ZwW0GQR1XS
A427	NHjj[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILmcXRKSzVyPUCuNFEzQTlizszN	MmXNV2FPT0WU
LCLC-97TM1	M1\RU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfoTWM2OD1yLkCxN{DPxE1?	MXnTRW5ITVJ?
AM-38	NH[xUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvCfndjUUN3ME2wMlAyOzB{IN88US=>	NXzLUoxyW0GQR1XS
K5	NFG1N5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NULoPZVGUUN3ME2wMlAyOzB6IN88US=>	MkDKV2FPT0WU
T84	MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXXUOnByUUN3ME2wMlAyOzNzIN88US=>	M1;FWnNCVkeHUh?=
TE-15	NYDQW2pwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnXNnVnUUN3ME2wMlAyOzN4IN88US=>	MXXTRW5ITVJ?
NCI-H460	Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DGVWlEPTB;MD6wNVM{PiEQvF2=	M4H3OnNCVkeHUh?=
NTERA-S-cl-D1	NHjxVGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3LaVGlEPTB;MD6wNVM{QSEQvF2=	MX7TRW5ITVJ?
KYSE-450	Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGficlBKSzVyPUCuNFE{PDlizszN	M{DCbHNCVkeHUh?=
H4	M3\wRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnONXNKSzVyPUCuNFE{PjZizszN	NXXZSG8zW0GQR1XS
LC-2-ad	MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWr3d29tUUN3ME2wMlAyOzdizszN	NUC5XVJVW0GQR1XS
GAMG	NI[3OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXHSIxKSzVyPUCuNFE{PzFizszN	NXLQflF{W0GQR1XS
TK10	MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVuyZVM4UUN3ME2wMlAyOzh{IN88US=>	MU\TRW5ITVJ?
NCI-H2122	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwMEGzPFQh\|ryP	MYjTRW5ITVJ?
KM12	NG\L[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPFfpdlUUN3ME2wMlAyOzl7IN88US=>	M3;Nc3NCVkeHUh?=
CAL-39	NWqxVoYyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3j5cmlEPTB;MD6wNVQzKM7:TR?=	M1jiSnNCVkeHUh?=
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MKN28	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVfIPVVzUUN3ME2wMlA{ODF{IN88US=>	MX7TRW5ITVJ?
SW837	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEXW[XhKSzVyPUCuNFMxOTRizszN	M2\IfnNCVkeHUh?=
no-10	MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnW1TWM2OD1yLkCzNFE3KM7:TR?=	MVPTRW5ITVJ?
BC-3	M2\SO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{TP[2lEPTB;MD6wN\|AyQCEQvF2=	NWTSNo5IW0GQR1XS
no-11	NVPtO3RET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIG2UG9KSzVyPUCuNFMxPDhizszN	M4\NSXNCVkeHUh?=
8305C	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;zNGlEPTB;MD6wN\|A4OiEQvF2=	NHqwcmdUSU6JRWK=
COLO-679	NYnQTlc5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3;YUGlEPTB;MD6wN\|ExPyEQvF2=	NFT2N2hUSU6JRWK=
CESS	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkTPTWM2OD1yLkCzNVIh\|ryP	NHvCUGpUSU6JRWK=
BFTC-909	NGTJdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoTqTWM2OD1yLkCzNVI2KM7:TR?=	MUnTRW5ITVJ?
MZ2-MEL	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHK3WndKSzVyPUCuNFMyPzdizszN	NEfMVHFUSU6JRWK=
SW872	M3zQbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPhTWM2OD1yLkCzNlE4KM7:TR?=	NIXKZ3dUSU6JRWK=
LB831-BLC	M4DBN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnSNZpVUUN3ME2wMlA{OjF7IN88US=>	NEPqcGdUSU6JRWK=
SK-UT-1	NYjlU2dbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMEOyNlEh\|ryP	NH7TSHhUSU6JRWK=
NCI-H1734	NVLMe2lpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkjzTWM2OD1yLkCzNlMh\|ryP	NVrsUlRRW0GQR1XS
OVCAR-8	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX73PXBFUUN3ME2wMlA{OjhzIN88US=>	MkDSV2FPT0WU
NCI-H2087	NXrJXYg1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MknjTWM2OD1yLkCzNlg6KM7:TR?=	M1ftPXNCVkeHUh?=
U-87-MG	NEXae\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIH3RnlKSzVyPUCuNFMzQSEQvF2=	NVjv[412W0GQR1XS
BC-1	MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTBwMEOzOlch\|ryP	NWC2UnhJW0GQR1XS
ES7	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX\SeoRpUUN3ME2wMlA{Ozd2IN88US=>	M1XjNnNCVkeHUh?=
Daudi	NHrrcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MknpTWM2OD1yLkCzN\|c3KM7:TR?=	NUKxNpZ6W0GQR1XS
RS4-11	NH7kU\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{\nZmlEPTB;MD6wN\|M5OyEQvF2=	NETDdZlUSU6JRWK=
JiyoyeP-2003	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWK4SpZnUUN3ME2wMlA{Ozh6IN88US=>	NFHLV3ZUSU6JRWK=
BL-70	MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwMEOzPFkh\|ryP	MXTTRW5ITVJ?
OS-RC-2	NWTMVJk2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mln4TWM2OD1yLkCzN\|k3KM7:TR?=	MmXRV2FPT0WU
SF268	MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGXmPGJKSzVyPUCuNFM1ODFizszN	MVLTRW5ITVJ?
BV-173	M2K0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTBwMEO0NlYh\|ryP	NGHxTFNUSU6JRWK=
DMS-273	MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHflXFJKSzVyPUCuNFM1PzlizszN	MVrTRW5ITVJ?
22RV1	M{jxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3q3bGlEPTB;MD6wN\|UxPyEQvF2=	MYfTRW5ITVJ?
ES8	MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTBwMEO1N\|gh\|ryP	MnTEV2FPT0WU
KYSE-150	MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDMb\|NJUUN3ME2wMlA{PjB6IN88US=>	MUTTRW5ITVJ?
HCC1569	M{XRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1f3cWlEPTB;MD6wN\|YxQCEQvF2=	MXzTRW5ITVJ?
NB5	NEnyfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTBwMEO2NVMh\|ryP	NVnFUGNVW0GQR1XS
G-402	M3;jR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjxSHJPUUN3ME2wMlA{PjF2IN88US=>	MX\TRW5ITVJ?
NCI-H1693	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmDZTWM2OD1yLkCzOlE4KM7:TR?=	MXHTRW5ITVJ?
LB2241-RCC	NYrsXIM6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWW1bHhuUUN3ME2wMlA{PjR{IN88US=>	NF;lZY5USU6JRWK=
KP-4	Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7pTWM2OD1yLkCzOlY{KM7:TR?=	MX3TRW5ITVJ?
ML-2	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTBwMEO2O\|Eh\|ryP	M1rGR3NCVkeHUh?=
KU812	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrtXVFpUUN3ME2wMlA{Pjh2IN88US=>	M3jR[HNCVkeHUh?=
LS-411N	NEjacGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTBwMEO3N\|Eh\|ryP	MYXTRW5ITVJ?
OAW-42	MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV7jPHZmUUN3ME2wMlA{PzR5IN88US=>	MXnTRW5ITVJ?
HCC38	NFH3OFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFPsd5NKSzVyPUCuNFM4PzFizszN	M4nPWXNCVkeHUh?=
Ca-Ski	NW\uPJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVnxNGg2UUN3ME2wMlA{Pzh2IN88US=>	MmPaV2FPT0WU
Calu-3	M4i0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUPRU\|J6UUN3ME2wMlA{Pzh7IN88US=>	M3rmOXNCVkeHUh?=
KYSE-70	NY\KTHBIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVv5Zox6UUN3ME2wMlA{QDF{IN88US=>	M2LjNXNCVkeHUh?=
D-392MG	MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoHoTWM2OD1yLkCzPFQzKM7:TR?=	MnfSV2FPT0WU
OVCAR-4	MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwMEO4OVgh\|ryP	NXziV4NCW0GQR1XS
Detroit562	MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV76XGkyUUN3ME2wMlA{QDd{IN88US=>	NE\YPItUSU6JRWK=
HEL	MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXPJR\|UxRTBwMEO4PVEh\|ryP	MmG3V2FPT0WU
MONO-MAC-6	NWDOWIVJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlnCTWM2OD1yLkCzPFk{KM7:TR?=	MYrTRW5ITVJ?
LoVo	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1PySGlEPTB;MD6wN\|k{OyEQvF2=	M13HO3NCVkeHUh?=
U-2-OS	NVH1RmJDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFWwZVlKSzVyPUCuNFM6OzVizszN	NGnmZpVUSU6JRWK=
A172	NYnTT4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2P6TmlEPTB;MD6wN\|k2KM7:TR?=	NFf2S\|lUSU6JRWK=
OCUB-M	MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnPDTWM2OD1yLkCzPVYyKM7:TR?=	NGXjPYhUSU6JRWK=
SW48	M{HWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwMESwN\|Eh\|ryP	NYD0UnZkW0GQR1XS
HC-1	NVXiVVJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXoTWM2OD1yLkC0NFY6KM7:TR?=	NX61UWxSW0GQR1XS
KOSC-2	M1jIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnnGTWM2OD1yLkC0NVEh\|ryP	MUDTRW5ITVJ?
HDLM-2	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIiyfIlKSzVyPUCuNFQyOTRizszN	NWPOfo15W0GQR1XS
CTV-1	NF7WVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUXKbXp6UUN3ME2wMlA1OTF4IN88US=>	NHzGRnZUSU6JRWK=
SH-4	NU\kcYx5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFiyWHhKSzVyPUCuNFQyPDFizszN	MoTyV2FPT0WU
SW756	NEG2c2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3nH[mlEPTB;MD6wOFE2PyEQvF2=	M3O4fnNCVkeHUh?=
GCT	M2HEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TVWGlEPTB;MD6wOFE3OSEQvF2=	Ml62V2FPT0WU
CHL-1	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWK0RnNCUUN3ME2wMlA1OTZ7IN88US=>	MlnaV2FPT0WU
LAMA-84	NGjvNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{jDN2lEPTB;MD6wOFE4OSEQvF2=	NFPNNHZUSU6JRWK=
LS-1034	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLTTWM2OD1yLkC0NVkyKM7:TR?=	NVf4NVVFW0GQR1XS
NCI-H358	M3TLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;hV4tKSzVyPUCuNFQzOTJizszN	NFW2PGlUSU6JRWK=
NB13	NIG2[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nFTmlEPTB;MD6wOFIzPyEQvF2=	NVf1TGJVW0GQR1XS
TE-9	NGG3VotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYjqXVNOUUN3ME2wMlA1OjN5IN88US=>	MXzTRW5ITVJ?
OE33	MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTSNYxbUUN3ME2wMlA1OjRzIN88US=>	NG\UU2pUSU6JRWK=
CAL-120	Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEn5boZKSzVyPUCuNFQzPDFizszN	M1HOU3NCVkeHUh?=
DJM-1	M3XOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLQTWM2OD1yLkC0NlczKM7:TR?=	NV:wOIx2W0GQR1XS
SK-MEL-24	Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkTBTWM2OD1yLkC0Nlg{KM7:TR?=	MVPTRW5ITVJ?
VA-ES-BJ	MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnrTWM2OD1yLkC0NlkzKM7:TR?=	MnvLV2FPT0WU
MMAC-SF	M1y5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGDGN2JKSzVyPUCuNFQzQTdizszN	MXXTRW5ITVJ?
MZ7-mel	NH[0SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTBwMESzN{DPxE1?	NETidFlUSU6JRWK=
BxPC-3	MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLTTWM2OD1yLkC0N\|QyKM7:TR?=	NXTaO2tXW0GQR1XS
HT-29	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvtNWFKSzVyPUCuNFQ{PTdizszN	M3nLbnNCVkeHUh?=
SK-MEL-30	M1LSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDsTWM2OD1yLkC0N\|YzKM7:TR?=	MlTyV2FPT0WU
CAL-33	Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwMESzO\|Uh\|ryP	NY[ydoZyW0GQR1XS
COLO-680N	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnLVTWM2OD1yLkC0OFA4KM7:TR?=	NX7UeWN4W0GQR1XS
NH-12	NVfWTlk4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoH6TWM2OD1yLkC0OFQh\|ryP	MnjnV2FPT0WU
HCC1937	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYK2cHJsUUN3ME2wMlA1PDV4IN88US=>	NF\EOFhUSU6JRWK=
IMR-5	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4L1OmlEPTB;MD6wOFQ6KM7:TR?=	M4PYb3NCVkeHUh?=
MC-CAR	NWnKe\|A1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGHB[HNKSzVyPUCuNFQ2PjlizszN	MkjPV2FPT0WU
NCI-H747	M4fMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fOSGlEPTB;MD6wOFU4KM7:TR?=	MnnLV2FPT0WU
NCI-H1792	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoT5TWM2OD1yLkC0OVgyKM7:TR?=	M3rUSXNCVkeHUh?=
SW13	MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2frcGlEPTB;MD6wOFU6KM7:TR?=	MVfTRW5ITVJ?
MLMA	Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHzvWpFKSzVyPUCuNFQ3ODlizszN	Mn\OV2FPT0WU
U251	Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;PdmlEPTB;MD6wOFc3OyEQvF2=	MUnTRW5ITVJ?
U031	MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUC1[IU5UUN3ME2wMlA1PzdzIN88US=>	NIDPTI1USU6JRWK=
ME-180	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMES3PFIh\|ryP	NYCye5RoW0GQR1XS
SK-MEL-3	NYLqN5JbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mom1TWM2OD1yLkC0PFAzKM7:TR?=	M3H0OHNCVkeHUh?=
MOLT-4	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnn1TWM2OD1yLkC0PFA{KM7:TR?=	Mn61V2FPT0WU
PF-382	M4PmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkG0TWM2OD1yLkC0PFI3KM7:TR?=	M3fpdnNCVkeHUh?=
NUGC-3	NXfSZ2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3vITGlEPTB;MD6wOFgzPyEQvF2=	NHXwdINUSU6JRWK=
NCI-H1417	NUfUTpJOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIfLW2pKSzVyPUCuNFQ5QSEQvF2=	MnfGV2FPT0WU
COLO-205	NUnHeYJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHu5WItKSzVyPUCuNFQ6OTlizszN	NUjkZmNUW0GQR1XS
TE-441-T	NELDR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRTBwMES5N{DPxE1?	MYjTRW5ITVJ?
MKN1	NXW1dW86T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoTqTWM2OD1yLkC0PVMh\|ryP	NX7I[JRiW0GQR1XS
UM-UC-3	Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjMc2s3UUN3ME2wMlA1QTVizszN	MlraV2FPT0WU
SF126	M1rUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmLYTWM2OD1yLkC1NFEh\|ryP	M4rpPHNCVkeHUh?=
LB1047-RCC	MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGT0e2RKSzVyPUCuNFUxOzFizszN	MmLRV2FPT0WU
A253	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLjeGtvUUN3ME2wMlA2ODV{IN88US=>	MX7TRW5ITVJ?
NCI-H1963	NICxPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmWzTWM2OD1yLkC1NVc3KM7:TR?=	NEDCO25USU6JRWK=
VM-CUB-1	MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnnPTWM2OD1yLkC1N\|EyKM7:TR?=	M1;TbXNCVkeHUh?=
T-24	MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\LZmlEPTB;MD6wOVM5PCEQvF2=	MWXTRW5ITVJ?
K-562	MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTBwMEWzPFch\|ryP	NX3SfZY6W0GQR1XS
ARH-77	NYDRTVV6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2nSRmlEPTB;MD6wOVM6PSEQvF2=	NYW0fIRFW0GQR1XS
CA46	M1:zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMEW0N{DPxE1?	MV3TRW5ITVJ?
HCC70	MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDVOYxoUUN3ME2wMlA2PDV{IN88US=>	NXfqN5Z{W0GQR1XS
ST486	NIi0NmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3nMZWlEPTB;MD6wOVUzPSEQvF2=	M2jUPHNCVkeHUh?=
COLO-741	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;uTWM2OD1yLkC1OVMyKM7:TR?=	M1vTdnNCVkeHUh?=
SK-PN-DW	Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2r1PWlEPTB;MD6wOVU5QCEQvF2=	NUT3b2lQW0GQR1XS
BL-41	NVrGUVh4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXPbGZKSzVyPUCuNFU2QTZizszN	MVjTRW5ITVJ?
D-263MG	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4X6fGlEPTB;MD6wOVY5OyEQvF2=	NWPlO5FuW0GQR1XS
KE-37	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTBwMEW2PFMh\|ryP	NWfGbYc{W0GQR1XS
LU-134-A	NVXTd3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnTT3dKSzVyPUCuNFU4OTVizszN	MmnyV2FPT0WU
HCC2157	M{Tqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUnJR\|UxRTBwMEW3N\|Mh\|ryP	NH24NXdUSU6JRWK=
GAK	NEK2c4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn3uTWM2OD1yLkC1O\|M1KM7:TR?=	M1XlZnNCVkeHUh?=
IST-SL2	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3P0S2lEPTB;MD6wOVc1OyEQvF2=	MVfTRW5ITVJ?
KMOE-2	NHLK[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojWTWM2OD1yLkC1O\|Q6KM7:TR?=	MWfTRW5ITVJ?
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NCI-H1755	NXnpPZRMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTBwMUO4Nlch\|ryP	M1X2TnNCVkeHUh?=
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KARPAS-422	MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{LqSWlEPTB;MD6xOFA{PyEQvF2=	MnjCV2FPT0WU
OVCAR-3	NVPQV5FVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjvTWM2OD1yLkG0NFc5KM7:TR?=	MVLTRW5ITVJ?
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HD-MY-Z	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTBwMUS0Nlkh\|ryP	MUPTRW5ITVJ?
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NCI-H1522	NInvfHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWfXbHd[UUN3ME2wMlE1Pzh5IN88US=>	MYXTRW5ITVJ?
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RCM-1	NGTMOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTBwMUW2PEDPxE1?	MmHDV2FPT0WU
COR-L279	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;tO3pDUUN3ME2wMlE2QDN4IN88US=>	MXHTRW5ITVJ?
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KLE	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWLtNIhLUUN3ME2wMlE3OTZ7IN88US=>	Mo\WV2FPT0WU
NCI-H2170	MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITSTolKSzVyPUCuNVY{ODRizszN	MX\TRW5ITVJ?
TGW	NGLvfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkfOTWM2OD1yLkG2OFcyKM7:TR?=	MVPTRW5ITVJ?
CAL-72	NXTOSJdzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVzJR\|UxRTBwMU[1PUDPxE1?	NWLtT5lYW0GQR1XS
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COR-L88	NGnLTm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH\nZnhKSzVyPUCuNVcyOTRizszN	M{Dnd3NCVkeHUh?=
HSC-4	NUjBWoo1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTBwMUexOkDPxE1?	NITiZlBUSU6JRWK=
GOTO	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTBwMUeyOFYh\|ryP	MkPmV2FPT0WU
MEG-01	NFLMeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUToSpFMUUN3ME2wMlE4OjV5IN88US=>	MlLDV2FPT0WU
MDA-MB-134-VI	NGe2WFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37Ld2lEPTB;MD6xO\|M3PyEQvF2=	M{LCN3NCVkeHUh?=
NCI-H596	MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml65TWM2OD1yLkG3N\|gh\|ryP	MYnTRW5ITVJ?
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NCI-H2171	MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwMUi2OFkh\|ryP	NHvJ[3pUSU6JRWK=
NCI-H526	MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTBwMUi2PVYh\|ryP	NEWxRXRUSU6JRWK=
MDA-MB-415	NXe1U2ttT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHH2fG9KSzVyPUCuNVk4PDhizszN	MoK2V2FPT0WU
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TE-11	M{LSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXJTWM2OD1yLkG5PVc2KM7:TR?=	MV7TRW5ITVJ?
LU-65	NFjUTFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvpdXlpUUN3ME2wMlIxOjFzIN88US=>	M{DObXNCVkeHUh?=
MKN45	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\y[Yg4UUN3ME2wMlIxPjRizszN	NF3QWI1USU6JRWK=
TGBC1TKB	NHXZXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTBwMkC5PVch\|ryP	M3WxPHNCVkeHUh?=
NCI-H2196	NXH5S2FUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvSNXdzUUN3ME2wMlIyPzR5IN88US=>	NX7Sc5l{W0GQR1XS
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NCI-H1436	M176U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{fWdGlEPTB;MD6yNVgzPiEQvF2=	NXHaRow3W0GQR1XS
EB-3	Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTBwMkKzO\|Yh\|ryP	NI[3WHpUSU6JRWK=
HT	Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnDTWM2OD1yLkKyOVY3KM7:TR?=	M4i3ZXNCVkeHUh?=
A3-KAW	NXfS[Gc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTBwMkK3NFgh\|ryP	MU\TRW5ITVJ?
DB	M1XHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHHLe5RKSzVyPUCuNlI5PjVizszN	MYXTRW5ITVJ?
KARPAS-299	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M33FdWlEPTB;MD6yNlk6PCEQvF2=	Ml\5V2FPT0WU
IM-9	NWSxfVBWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoW3TWM2OD1yLkKzOFc3KM7:TR?=	M1zoNHNCVkeHUh?=
NCI-H838	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHSRVNrUUN3ME2wMlI{PzF2IN88US=>	MYHTRW5ITVJ?
NB10	Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTBwMkO3N\|Eh\|ryP	M{PHXnNCVkeHUh?=
NCI-H2141	NVf1Roh6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnKxTWM2OD1yLkKzPFQyKM7:TR?=	M2jRZXNCVkeHUh?=
LB647-SCLC	MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXjUOmhKUUN3ME2wMlI1ODF2IN88US=>	NYDONY1SW0GQR1XS
NCI-H23	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;CTWM2OD1yLkK0NFU6KM7:TR?=	NV7ndI9SW0GQR1XS
MN-60	NYX0d5g1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXu1OHRiUUN3ME2wMlI1OjN7IN88US=>	M3ywcnNCVkeHUh?=
CAL-148	NHmyZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTBwMkSyPFIh\|ryP	MYLTRW5ITVJ?
EFE-184	MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\3SFVjUUN3ME2wMlI1PTl5IN88US=>	M4TQNXNCVkeHUh?=
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SN12C	MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;nTWM2OD1yLkK0Olk1KM7:TR?=	MoXNV2FPT0WU
CAKI-1	MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIP4NnBKSzVyPUCuNlUxQDZizszN	M{D3dHNCVkeHUh?=
MHH-NB-11	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTuTWM2OD1yLkK1N\|Uh\|ryP	M1zxOHNCVkeHUh?=
DOK	NU\6SWc6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGfweHdKSzVyPUCuNlU6OyEQvF2=	M1rFcXNCVkeHUh?=
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NCI-H69	NFXaSmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2fYZWlEPTB;MD6yO\|IxOSEQvF2=	NIDT[4NUSU6JRWK=
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NCI-H1618	M{m4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmT5TWM2OD1yLkK3OVEh\|ryP	MYHTRW5ITVJ?
NCI-SNU-5	Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXvYOI5QUUN3ME2wMlI4PjF\|IN88US=>	MYDTRW5ITVJ?
NCI-H1694	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTBwMke3N\|Mh\|ryP	NXLP[FdnW0GQR1XS
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SW684	M{TiZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwMkizPFMh\|ryP	M13IdXNCVkeHUh?=
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NCI-H510A	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTBwMkmzNFQh\|ryP	MYTTRW5ITVJ?
Mo-T	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnFSFdKSzVyPUCuNlk{OzFizszN	NHfycYtUSU6JRWK=
LB373-MEL-D	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fWVGlEPTB;MD6yPVQ{OSEQvF2=	NFjt[opUSU6JRWK=
NCI-H28	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{HNOmlEPTB;MD6yPVg{PyEQvF2=	MVLTRW5ITVJ?
NCI-H446	Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHLuZmZKSzVyPUCuNlk6OjFizszN	NEPCXGZUSU6JRWK=
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OPM-2	MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYLscphTUUN3ME2wMlMyODZ2IN88US=>	NFSwOJhUSU6JRWK=
BT-20	M1O0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmX5TWM2OD1yLkOxNFk6KM7:TR?=	NUTJSoVTW0GQR1XS
KP-N-YN	M1[xeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn71TWM2OD1yLkOxNVE5KM7:TR?=	NITHc4tUSU6JRWK=
MDA-MB-175-VII	MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFf2ZYxKSzVyPUCuN\|I{PDhizszN	NIjxdFlUSU6JRWK=
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COLO-678	M{f2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkHCTWM2OD1yLkOzN\|g6KM7:TR?=	M1LWO3NCVkeHUh?=
COLO-829	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M16yd2lEPTB;MD6zOFQ2OiEQvF2=	NIXMWY1USU6JRWK=
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NCI-H719	NGf4Oo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLJTWM2OD1yLkO1NVI1KM7:TR?=	NUH5c5pNW0GQR1XS
MFE-280	M1XVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTBwM{W3NVUh\|ryP	M1;pSHNCVkeHUh?=
DMS-114	NIS0V29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUfJR\|UxRTBwM{[xNkDPxE1?	MXrTRW5ITVJ?
RMG-I	NEe1[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnPTWM2OD1yLkO2OlkyKM7:TR?=	M3T6bnNCVkeHUh?=
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HPAF-II	Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4TqVWlEPTB;MD60NVEyPyEQvF2=	M3;zWXNCVkeHUh?=
NCI-H1882	M3\iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MW\JR\|UxRTBwNEG3PFQh\|ryP	NFjON4dUSU6JRWK=
JVM-2	NUnjWpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2TXbWlEPTB;MD60OFQxOSEQvF2=	MWnTRW5ITVJ?
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MHH-CALL-2	NHP3d29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlXpTWM2OD1yLkS0PFMh\|ryP	MlPuV2FPT0WU
NCI-H716	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXaOoNKSzVyPUCuOFQ5PDhizszN	MXXTRW5ITVJ?
NEC8	MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYO0VJR3UUN3ME2wMlQ2OTR3IN88US=>	MVfTRW5ITVJ?
UACC-812	M4Xzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4jOOmlEPTB;MD60Olc4PiEQvF2=	M3T2PXNCVkeHUh?=
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MDA-MB-157	NXvHRYFlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTVwNk[0OFMh\|ryP	MoHvV2FPT0WU
NCI-H1623	M2Xzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmi5TWM2OD13LkizOVU3KM7:TR?=	NUD0TpNIW0GQR1XS
RPMI-8866	NITWWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1m5cmlEPTB;NT64OFc6OiEQvF2=	M2HJNnNCVkeHUh?=
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TT	M4[2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmKzTWM2OD16LkOzNFA6KM7:TR?=	MnPuV2FPT0WU
NCI-H1838	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzCdZR6UUN3ME24MlUyPzNzIN88US=>	Ml7mV2FPT0WU
NCI-H322M	Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rpfWlEPTB;OT6xOlI5OSEQvF2=	NFnNOFRUSU6JRWK=
NCI-H187	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTlwNUG4N\|Uh\|ryP	MX\TRW5ITVJ?
SBC-1	MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TKWGlEPTB;OT65N\|Y2PiEQvF2=	MYrTRW5ITVJ?
SCC-3	NYLDV\|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\Dcm9TUUN3ME2xNE42Pjd7IN88US=>	NULhUo9GW0GQR1XS
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CPC-N	Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7MTWM2OD1zMT6wNFch\|ryP	M37pOXNCVkeHUh?=
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NCI-H2452	M3\TbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYfJR\|UxRTF2LkezJO69VQ>?	NUfjNYh2W0GQR1XS
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DV-90	MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPQWnZKSzVyPUG4Mlk6PDVizszN	M3TOPHNCVkeHUh?=
NCI-H1563	M2jiUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGjQeIxKSzVyPUG5Mlc5QDhizszN	NYTTXVdlW0GQR1XS
SW780	NUP6WmJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVPJR\|UxRTJzLkGzNVgh\|ryP	MXHTRW5ITVJ?
NCI-H345	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjEeVJKSzVyPUKxMlg4PzlizszN	MWrTRW5ITVJ?
LB771-HNC	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVXJR\|UxRTJ{LkS4NVMh\|ryP	NH76W2RUSU6JRWK=
RT4	M1XZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYeyW4lwUUN3ME2yN{4{Ojh{IN88US=>	NX60b3VSW0GQR1XS
NCI-H82	NED1UYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTJ\|LkW1NlYh\|ryP	NUThO\|dOW0GQR1XS
NCI-H524	NI\YSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTJ2LkO4NVIh\|ryP	MnPyV2FPT0WU
SNU-C1	NXfQfVhFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWjJR\|UxRTJ2LkmxNFUh\|ryP	M3;QfHNCVkeHUh?=
NCI-SNU-16	NHPkTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\6TWM2OD12OD6zNVQzKM7:TR?=	MVzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	+ Expand Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	+ Expand Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	+ Expand Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products4

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

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Luminespib (AUY-922, NVP-AUY922)

Cited by 25 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 25 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)