Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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Cited by 25 Publications

3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LUbWlEPTB;MD6wNFAyOjVizszN NHPEem5USU6JRWK=
MV-4-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknZTWM2OD1yLkCwNFU2QCEQvF2= M36zbnNCVkeHUh?=
NALM-6 NXPpVYhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXXTWM2OD1yLkCwNFg1OiEQvF2= MVvTRW5ITVJ?
HOS NWD5PIQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMECxN|gh|ryP NGe2OpRUSU6JRWK=
HT-144 NXXQd4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrhdW1KSzVyPUCuNFAyPTVizszN NUjoW3o5W0GQR1XS
SW1710 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL6SolKSzVyPUCuNFAyQDZizszN MUfTRW5ITVJ?
TE-8 NF7RPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e5dmlEPTB;MD6wNFI{PyEQvF2= NVj2ZlkyW0GQR1XS
ES1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi0TWM2OD1yLkCwNlY3KM7:TR?= MYnTRW5ITVJ?
CCF-STTG1 M2jsPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH4SmJiUUN3ME2wMlAxOjl5IN88US=> M4\wTnNCVkeHUh?=
PSN1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLOcIRKSzVyPUCuNFA{OThizszN M2PMeXNCVkeHUh?=
CAL-51 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HUU2lEPTB;MD6wNFMzPSEQvF2= MUjTRW5ITVJ?
MCF7 NEPJ[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmewTWM2OD1yLkCwN|M2KM7:TR?= MnXWV2FPT0WU
SK-HEP-1 NFfjTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfjNYVKSzVyPUCuNFA{OzZizszN NEXpdXhUSU6JRWK=
LCLC-103H MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTHXYJxUUN3ME2wMlAxPDNizszN MnXBV2FPT0WU
HMV-II MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGxXJdxUUN3ME2wMlAxPDR7IN88US=> NGfuXGlUSU6JRWK=
MES-SA NX;GUYVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jWdGlEPTB;MD6wNFQ2OiEQvF2= M2C1bXNCVkeHUh?=
SK-LMS-1 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEC0OVgh|ryP NXTBUGdJW0GQR1XS
639-V NISyWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrhTWM2OD1yLkCwOFg2KM7:TR?= Mm\LV2FPT0WU
SIG-M5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHpTWM2OD1yLkCwOFg6KM7:TR?= M1\jUHNCVkeHUh?=
LOUCY NVWyVm5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlywTWM2OD1yLkCwOVA2KM7:TR?= M{[wbnNCVkeHUh?=
HSC-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPnXYtjUUN3ME2wMlAxPTF6IN88US=> M37kW3NCVkeHUh?=
EW-13 MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnMdmVKSzVyPUCuNFA2OThizszN M1;WNXNCVkeHUh?=
RT-112 M33QeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrGbIpKSzVyPUCuNFA2OzVizszN M3zVSnNCVkeHUh?=
NKM-1 M3nsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLadpJKSzVyPUCuNFA2PDdizszN MYTTRW5ITVJ?
KYSE-180 NFfUcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX60[XNKUUN3ME2wMlAxPTh4IN88US=> MUPTRW5ITVJ?
SW1783 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;3VmlEPTB;MD6wNFU6OSEQvF2= MX;TRW5ITVJ?
A431 NVu1XIp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEC2NFch|ryP M2PEZXNCVkeHUh?=
SK-OV-3 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLZNVRqUUN3ME2wMlAxPjNizszN M1nwUnNCVkeHUh?=
RPMI-7951 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\6bGlEPTB;MD6wNFY{OSEQvF2= M1vxTnNCVkeHUh?=
Capan-2 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD1yLkCwOlM5KM7:TR?= M1j0OXNCVkeHUh?=
HSC-3 NYjZPHlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrTSmdKSzVyPUCuNFA3PDFizszN MXHTRW5ITVJ?
786-0 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXftfGNMUUN3ME2wMlAxPjZ|IN88US=> NGLPZZNUSU6JRWK=
Daoy M3PoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\XSGlEPTB;MD6wNFY6PSEQvF2= NUnPV2xmW0GQR1XS
KGN NIraWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEC3NFMh|ryP NYjEN2ZZW0GQR1XS
EW-16 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG4eFBKSzVyPUCuNFA4PDlizszN M{\KcnNCVkeHUh?=
EW-7 NWrKU|BQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEC3OVQh|ryP MYXTRW5ITVJ?
IGROV-1 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TOSWlEPTB;MD6wNFgyPCEQvF2= MYLTRW5ITVJ?
8505C NWLnNHE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\NcWhKSzVyPUCuNFA5OjFizszN M3T4Z3NCVkeHUh?=
RKO MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTxTWM2OD1yLkCwPFI3KM7:TR?= MnfRV2FPT0WU
GDM-1 NWrnSVVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEC4OEDPxE1? M1;3V3NCVkeHUh?=
IST-MEL1 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rxNGlEPTB;MD6wNFg2OiEQvF2= NGrSdXBUSU6JRWK=
RPMI-6666 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvvboUzUUN3ME2wMlAxQDV{IN88US=> NELCVllUSU6JRWK=
SNG-M MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLpWmZKSzVyPUCuNFA5PTZizszN NHPvWIFUSU6JRWK=
KS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEC4OVkh|ryP MmPqV2FPT0WU
RXF393 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorzTWM2OD1yLkCwPFYh|ryP MlLSV2FPT0WU
CAL-12T M4TORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEC5NlIh|ryP Mn;RV2FPT0WU
BFTC-905 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP2[ItKSzVyPUCuNFA6OzhizszN MUjTRW5ITVJ?
SK-MES-1 M3fKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULZcox3UUN3ME2wMlAxQTR3IN88US=> MYTTRW5ITVJ?
BB30-HNC Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m3SmlEPTB;MD6wNFk2OiEQvF2= Mkn6V2FPT0WU
AN3-CA MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEGwNVch|ryP NYC5TJVXW0GQR1XS
EFO-27 NILuRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXexW5ZJUUN3ME2wMlAyODF5IN88US=> NGTme4RUSU6JRWK=
G-401 NEPUNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEGwNlUh|ryP NVPJRopsW0GQR1XS
BPH-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEGwN{DPxE1? MmrDV2FPT0WU
NCI-H727 NFHGdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtTWM2OD1yLkCxNFMh|ryP NWrLfGJyW0GQR1XS
SNU-423 M3HrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LlXWlEPTB;MD6wNVA2OyEQvF2= NXfFdYJ3W0GQR1XS
KYSE-270 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjUTWM2OD1yLkCxNFU6KM7:TR?= Mo\xV2FPT0WU
AGS NEH1c3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX0SZlKSzVyPUCuNFExPjFizszN MnPCV2FPT0WU
NCI-H2228 NFfzdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjKd28yUUN3ME2wMlAyODZ2IN88US=> M1P4WXNCVkeHUh?=
SW954 NYj5TGlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DQZ2lEPTB;MD6wNVA4OSEQvF2= MXrTRW5ITVJ?
769-P NEDa[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP4cXpKSzVyPUCuNFExPzNizszN NY\rXId6W0GQR1XS
BB49-HNC M4XlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jw[mlEPTB;MD6wNVA4PyEQvF2= MYrTRW5ITVJ?
IA-LM M4nwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fZW2lEPTB;MD6wNVA5PiEQvF2= M2LPRXNCVkeHUh?=
NB69 NIPQdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rRZ2lEPTB;MD6wNVExOiEQvF2= M2LOTXNCVkeHUh?=
C8166 NYG1UY1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL3TWM2OD1yLkCxNVI6KM7:TR?= MWnTRW5ITVJ?
NCI-H1299 NWS3dFhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLEcplKSzVyPUCuNFEyPTRizszN M{HXVXNCVkeHUh?=
YKG-1 M13XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTYTWM2OD1yLkCxNVYh|ryP NF3J[HJUSU6JRWK=
PANC-03-27 M4DsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEGxOlIh|ryP MnTYV2FPT0WU
YT M3GzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEGxO|kh|ryP MkjXV2FPT0WU
CAL-85-1 M3PkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K4WWlEPTB;MD6wNVE6OiEQvF2= NVL6UlhxW0GQR1XS
GT3TKB NVfQTGZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULZdHFnUUN3ME2wMlAyOjB{IN88US=> NEHEV3pUSU6JRWK=
BB65-RCC NUPxdXdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrlPFZKSzVyPUCuNFEzODRizszN NH\K[VlUSU6JRWK=
ES6 NF\Lb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;FXpRXUUN3ME2wMlAyOjZzIN88US=> NXPpUWVYW0GQR1XS
MHH-ES-1 NWrldm5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PQcWlEPTB;MD6wNVI3OyEQvF2= MUTTRW5ITVJ?
QIMR-WIL M4f1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W4VGlEPTB;MD6wNVI3QSEQvF2= NILtfYpUSU6JRWK=
SNU-C2B M4DqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPGTWM2OD1yLkCxNlczKM7:TR?= NEO0U3JUSU6JRWK=
OCI-AML2 M4f0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEGyPFEh|ryP MVjTRW5ITVJ?
DU-145 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEGyPUDPxE1? MUDTRW5ITVJ?
SW982 NV7zOXNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLHc4xKSzVyPUCuNFEzQTNizszN MV;TRW5ITVJ?
MFH-ino Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL1U5JDUUN3ME2wMlAyOjl|IN88US=> NVTVS4ZwW0GQR1XS
A427 NHjj[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILmcXRKSzVyPUCuNFEzQTlizszN MmXNV2FPT0WU
LCLC-97TM1 M1\RU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfoTWM2OD1yLkCxN{DPxE1? MXnTRW5ITVJ?
AM-38 NH[xUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvCfndjUUN3ME2wMlAyOzB{IN88US=> NXzLUoxyW0GQR1XS
K5 NFG1N5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULoPZVGUUN3ME2wMlAyOzB6IN88US=> MkDKV2FPT0WU
T84 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXUOnByUUN3ME2wMlAyOzNzIN88US=> M1;FWnNCVkeHUh?=
TE-15 NYDQW2pwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnXNnVnUUN3ME2wMlAyOzN4IN88US=> MXXTRW5ITVJ?
NCI-H460 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DGVWlEPTB;MD6wNVM{PiEQvF2= M4H3OnNCVkeHUh?=
NTERA-S-cl-D1 NHjxVGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LaVGlEPTB;MD6wNVM{QSEQvF2= MX7TRW5ITVJ?
KYSE-450 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGficlBKSzVyPUCuNFE{PDlizszN M{DCbHNCVkeHUh?=
H4 M3\wRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnONXNKSzVyPUCuNFE{PjZizszN NXXZSG8zW0GQR1XS
LC-2-ad MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr3d29tUUN3ME2wMlAyOzdizszN NUC5XVJVW0GQR1XS
GAMG NI[3OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXHSIxKSzVyPUCuNFE{PzFizszN NXLQflF{W0GQR1XS
TK10 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuyZVM4UUN3ME2wMlAyOzh{IN88US=> MU\TRW5ITVJ?
NCI-H2122 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEGzPFQh|ryP MYjTRW5ITVJ?
KM12 NG\L[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPFfpdlUUN3ME2wMlAyOzl7IN88US=> M3;Nc3NCVkeHUh?=
CAL-39 NWqxVoYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j5cmlEPTB;MD6wNVQzKM7:TR?= M1jiSnNCVkeHUh?=
RPMI-2650 NVjPe5lWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEG0N|Ih|ryP NVvCd2o3W0GQR1XS
KYSE-510 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknmTWM2OD1yLkCxOFQzKM7:TR?= NYLUepp6W0GQR1XS
KALS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzYO|BIUUN3ME2wMlAyPDZ4IN88US=> Ml2yV2FPT0WU
NCI-H1648 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkixTWM2OD1yLkCxOFk6KM7:TR?= MXjTRW5ITVJ?
ES4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfMTWM2OD1yLkCxOVAzKM7:TR?= MlnFV2FPT0WU
C-33-A NHzq[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTNTWM2OD1yLkCxOVA6KM7:TR?= NYTjS2Q1W0GQR1XS
MIA-PaCa-2 MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXyTWM2OD1yLkCxOVA6KM7:TR?= MmTkV2FPT0WU
Becker MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXOfFR{UUN3ME2wMlAyPTF2IN88US=> NE\vNVlUSU6JRWK=
HOP-62 NWLsWVJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT2WVg{UUN3ME2wMlAyPTR{IN88US=> NIf3N4JUSU6JRWK=
TE-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrRcpdWUUN3ME2wMlAyPThzIN88US=> NIPObnBUSU6JRWK=
KYSE-410 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XrVWlEPTB;MD6wNVU5PiEQvF2= MmDTV2FPT0WU
NOS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fpR2lEPTB;MD6wNVU6OyEQvF2= NIDIcZhUSU6JRWK=
MEL-HO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrSTJFGUUN3ME2wMlAyPjR|IN88US=> M2[3NnNCVkeHUh?=
NCI-H1650 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT6RnA6UUN3ME2wMlAyPjR4IN88US=> NFraNlNUSU6JRWK=
VMRC-RCZ NUC0ZpJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDETWM2OD1yLkCxOlUyKM7:TR?= MXfTRW5ITVJ?
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U-87-MG NEXae|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH3RnlKSzVyPUCuNFMzQSEQvF2= NVjv[412W0GQR1XS
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RS4-11 NH7kU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\nZmlEPTB;MD6wN|M5OyEQvF2= NETDdZlUSU6JRWK=
JiyoyeP-2003 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK4SpZnUUN3ME2wMlA{Ozh6IN88US=> NFHLV3ZUSU6JRWK=
BL-70 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEOzPFkh|ryP MXTTRW5ITVJ?
OS-RC-2 NWTMVJk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln4TWM2OD1yLkCzN|k3KM7:TR?= MmXRV2FPT0WU
SF268 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXmPGJKSzVyPUCuNFM1ODFizszN MVLTRW5ITVJ?
BV-173 M2K0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEO0NlYh|ryP NGHxTFNUSU6JRWK=
DMS-273 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHflXFJKSzVyPUCuNFM1PzlizszN MVrTRW5ITVJ?
22RV1 M{jxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q3bGlEPTB;MD6wN|UxPyEQvF2= MYfTRW5ITVJ?
ES8 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEO1N|gh|ryP MnTEV2FPT0WU
KYSE-150 MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDMb|NJUUN3ME2wMlA{PjB6IN88US=> MUTTRW5ITVJ?
HCC1569 M{XRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f3cWlEPTB;MD6wN|YxQCEQvF2= MXzTRW5ITVJ?
NB5 NEnyfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEO2NVMh|ryP NVnFUGNVW0GQR1XS
G-402 M3;jR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjxSHJPUUN3ME2wMlA{PjF2IN88US=> MX\TRW5ITVJ?
NCI-H1693 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDZTWM2OD1yLkCzOlE4KM7:TR?= MXHTRW5ITVJ?
LB2241-RCC NYrsXIM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW1bHhuUUN3ME2wMlA{PjR{IN88US=> NF;lZY5USU6JRWK=
KP-4 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7pTWM2OD1yLkCzOlY{KM7:TR?= MX3TRW5ITVJ?
ML-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEO2O|Eh|ryP M1rGR3NCVkeHUh?=
KU812 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrtXVFpUUN3ME2wMlA{Pjh2IN88US=> M3jR[HNCVkeHUh?=
LS-411N NEjacGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEO3N|Eh|ryP MYXTRW5ITVJ?
OAW-42 MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7jPHZmUUN3ME2wMlA{PzR5IN88US=> MXnTRW5ITVJ?
HCC38 NFH3OFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPsd5NKSzVyPUCuNFM4PzFizszN M4nPWXNCVkeHUh?=
Ca-Ski NW\uPJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnxNGg2UUN3ME2wMlA{Pzh2IN88US=> MmPaV2FPT0WU
Calu-3 M4i0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPRU|J6UUN3ME2wMlA{Pzh7IN88US=> M3rmOXNCVkeHUh?=
KYSE-70 NY\KTHBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv5Zox6UUN3ME2wMlA{QDF{IN88US=> M2LjNXNCVkeHUh?=
D-392MG MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHoTWM2OD1yLkCzPFQzKM7:TR?= MnfSV2FPT0WU
OVCAR-4 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEO4OVgh|ryP NXziV4NCW0GQR1XS
Detroit562 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV76XGkyUUN3ME2wMlA{QDd{IN88US=> NE\YPItUSU6JRWK=
HEL MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEO4PVEh|ryP MmG3V2FPT0WU
MONO-MAC-6 NWDOWIVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnCTWM2OD1yLkCzPFk{KM7:TR?= MYrTRW5ITVJ?
LoVo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PySGlEPTB;MD6wN|k{OyEQvF2= M13HO3NCVkeHUh?=
U-2-OS NVH1RmJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWwZVlKSzVyPUCuNFM6OzVizszN NGnmZpVUSU6JRWK=
A172 NYnTT4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P6TmlEPTB;MD6wN|k2KM7:TR?= NFf2S|lUSU6JRWK=
OCUB-M MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPDTWM2OD1yLkCzPVYyKM7:TR?= NGXjPYhUSU6JRWK=
SW48 M{HWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMESwN|Eh|ryP NYD0UnZkW0GQR1XS
HC-1 NVXiVVJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXoTWM2OD1yLkC0NFY6KM7:TR?= NX61UWxSW0GQR1XS
KOSC-2 M1jIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnGTWM2OD1yLkC0NVEh|ryP MUDTRW5ITVJ?
HDLM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiyfIlKSzVyPUCuNFQyOTRizszN NWPOfo15W0GQR1XS
CTV-1 NF7WVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXKbXp6UUN3ME2wMlA1OTF4IN88US=> NHzGRnZUSU6JRWK=
SH-4 NU\kcYx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiyWHhKSzVyPUCuNFQyPDFizszN MoTyV2FPT0WU
SW756 NEG2c2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nH[mlEPTB;MD6wOFE2PyEQvF2= M3O4fnNCVkeHUh?=
GCT M2HEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TVWGlEPTB;MD6wOFE3OSEQvF2= Ml62V2FPT0WU
CHL-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK0RnNCUUN3ME2wMlA1OTZ7IN88US=> MlnaV2FPT0WU
LAMA-84 NGjvNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDN2lEPTB;MD6wOFE4OSEQvF2= NFPNNHZUSU6JRWK=
LS-1034 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLTTWM2OD1yLkC0NVkyKM7:TR?= NVf4NVVFW0GQR1XS
NCI-H358 M3TLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;hV4tKSzVyPUCuNFQzOTJizszN NFW2PGlUSU6JRWK=
NB13 NIG2[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nFTmlEPTB;MD6wOFIzPyEQvF2= NVf1TGJVW0GQR1XS
TE-9 NGG3VotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjqXVNOUUN3ME2wMlA1OjN5IN88US=> MXzTRW5ITVJ?
OE33 MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTSNYxbUUN3ME2wMlA1OjRzIN88US=> NG\UU2pUSU6JRWK=
CAL-120 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn5boZKSzVyPUCuNFQzPDFizszN M1HOU3NCVkeHUh?=
DJM-1 M3XOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLQTWM2OD1yLkC0NlczKM7:TR?= NV:wOIx2W0GQR1XS
SK-MEL-24 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTBTWM2OD1yLkC0Nlg{KM7:TR?= MVPTRW5ITVJ?
VA-ES-BJ MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnrTWM2OD1yLkC0NlkzKM7:TR?= MnvLV2FPT0WU
MMAC-SF M1y5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDGN2JKSzVyPUCuNFQzQTdizszN MXXTRW5ITVJ?
MZ7-mel NH[0SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMESzN{DPxE1? NETidFlUSU6JRWK=
BxPC-3 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLTTWM2OD1yLkC0N|QyKM7:TR?= NXTaO2tXW0GQR1XS
HT-29 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvtNWFKSzVyPUCuNFQ{PTdizszN M3nLbnNCVkeHUh?=
SK-MEL-30 M1LSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDsTWM2OD1yLkC0N|YzKM7:TR?= MlTyV2FPT0WU
CAL-33 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMESzO|Uh|ryP NY[ydoZyW0GQR1XS
COLO-680N MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLVTWM2OD1yLkC0OFA4KM7:TR?= NX7UeWN4W0GQR1XS
NH-12 NVfWTlk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH6TWM2OD1yLkC0OFQh|ryP MnjnV2FPT0WU
HCC1937 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK2cHJsUUN3ME2wMlA1PDV4IN88US=> NF\EOFhUSU6JRWK=
IMR-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L1OmlEPTB;MD6wOFQ6KM7:TR?= M4PYb3NCVkeHUh?=
MC-CAR NWnKe|A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHB[HNKSzVyPUCuNFQ2PjlizszN MkjPV2FPT0WU
NCI-H747 M4fMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fOSGlEPTB;MD6wOFU4KM7:TR?= MnnLV2FPT0WU
NCI-H1792 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT5TWM2OD1yLkC0OVgyKM7:TR?= M3rUSXNCVkeHUh?=
SW13 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2frcGlEPTB;MD6wOFU6KM7:TR?= MVfTRW5ITVJ?
MLMA Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzvWpFKSzVyPUCuNFQ3ODlizszN Mn\OV2FPT0WU
U251 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;PdmlEPTB;MD6wOFc3OyEQvF2= MUnTRW5ITVJ?
U031 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC1[IU5UUN3ME2wMlA1PzdzIN88US=> NIDPTI1USU6JRWK=
ME-180 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMES3PFIh|ryP NYCye5RoW0GQR1XS
SK-MEL-3 NYLqN5JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom1TWM2OD1yLkC0PFAzKM7:TR?= M3H0OHNCVkeHUh?=
MOLT-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn1TWM2OD1yLkC0PFA{KM7:TR?= Mn61V2FPT0WU
PF-382 M4PmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG0TWM2OD1yLkC0PFI3KM7:TR?= M3fpdnNCVkeHUh?=
NUGC-3 NXfSZ2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vITGlEPTB;MD6wOFgzPyEQvF2= NHXwdINUSU6JRWK=
NCI-H1417 NUfUTpJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfLW2pKSzVyPUCuNFQ5QSEQvF2= MnfGV2FPT0WU
COLO-205 NUnHeYJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5WItKSzVyPUCuNFQ6OTlizszN NUjkZmNUW0GQR1XS
TE-441-T NELDR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMES5N{DPxE1? MYjTRW5ITVJ?
MKN1 NXW1dW86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTqTWM2OD1yLkC0PVMh|ryP NX7I[JRiW0GQR1XS
UM-UC-3 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjMc2s3UUN3ME2wMlA1QTVizszN MlraV2FPT0WU
SF126 M1rUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLYTWM2OD1yLkC1NFEh|ryP M4rpPHNCVkeHUh?=
LB1047-RCC MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT0e2RKSzVyPUCuNFUxOzFizszN MmLRV2FPT0WU
A253 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLjeGtvUUN3ME2wMlA2ODV{IN88US=> MX7TRW5ITVJ?
NCI-H1963 NICxPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWzTWM2OD1yLkC1NVc3KM7:TR?= NEDCO25USU6JRWK=
VM-CUB-1 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnPTWM2OD1yLkC1N|EyKM7:TR?= M1;TbXNCVkeHUh?=
T-24 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\LZmlEPTB;MD6wOVM5PCEQvF2= MWXTRW5ITVJ?
K-562 MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEWzPFch|ryP NX3SfZY6W0GQR1XS
ARH-77 NYDRTVV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nSRmlEPTB;MD6wOVM6PSEQvF2= NYW0fIRFW0GQR1XS
CA46 M1:zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEW0N{DPxE1? MV3TRW5ITVJ?
HCC70 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDVOYxoUUN3ME2wMlA2PDV{IN88US=> NXfqN5Z{W0GQR1XS
ST486 NIi0NmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nMZWlEPTB;MD6wOVUzPSEQvF2= M2jUPHNCVkeHUh?=
COLO-741 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;uTWM2OD1yLkC1OVMyKM7:TR?= M1vTdnNCVkeHUh?=
SK-PN-DW Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r1PWlEPTB;MD6wOVU5QCEQvF2= NUT3b2lQW0GQR1XS
BL-41 NVrGUVh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXPbGZKSzVyPUCuNFU2QTZizszN MVjTRW5ITVJ?
D-263MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X6fGlEPTB;MD6wOVY5OyEQvF2= NWPlO5FuW0GQR1XS
KE-37 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEW2PFMh|ryP NWfGbYc{W0GQR1XS
LU-134-A NVXTd3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnTT3dKSzVyPUCuNFU4OTVizszN MmnyV2FPT0WU
HCC2157 M{Tqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEW3N|Mh|ryP NH24NXdUSU6JRWK=
GAK NEK2c4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3uTWM2OD1yLkC1O|M1KM7:TR?= M1XlZnNCVkeHUh?=
IST-SL2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P0S2lEPTB;MD6wOVc1OyEQvF2= MVfTRW5ITVJ?
KMOE-2 NHLK[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojWTWM2OD1yLkC1O|Q6KM7:TR?= MWfTRW5ITVJ?
SW1573 M2K5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjUVm93UUN3ME2wMlA2QDB{IN88US=> NXHYV4JFW0GQR1XS
SCC-9 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW5THRKSzVyPUCuNFU5PyEQvF2= MUnTRW5ITVJ?
MDA-MB-361 M2K4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rySGlEPTB;MD6wOVg4OiEQvF2= NX;kWm1WW0GQR1XS
BHT-101 M2m3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPvTG5KSzVyPUCuNFU5PzZizszN M{XLcnNCVkeHUh?=
NCI-H1770 NVXkTnh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fkZWlEPTB;MD6wOVg4QSEQvF2= NEi1dHRUSU6JRWK=
UACC-893 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLLTWM2OD1yLkC1PFk3KM7:TR?= NFX6NmVUSU6JRWK=
NCI-H226 NFjHPYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS1TWM2OD1yLkC1PVg5KM7:TR?= M2H4NXNCVkeHUh?=
HLE M3\uN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwME[wPFIh|ryP NYL5dWhtW0GQR1XS
NCI-H1703 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6yO4xKSzVyPUCuNFYyPzhizszN MlLoV2FPT0WU
KURAMOCHI M2\DWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonMTWM2OD1yLkC2NVg6KM7:TR?= Mo\zV2FPT0WU
RH-1 NY\ITm15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLhTWM2OD1yLkC2NlMh|ryP MoLjV2FPT0WU
DSH1 M3v0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXryTGRHUUN3ME2wMlA3OjdizszN M1zQeXNCVkeHUh?=
CAMA-1 M{PvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK5ZW5xUUN3ME2wMlA3OzB|IN88US=> NWjNRm8yW0GQR1XS
NCI-H1437 NWXybG43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwME[zNlgh|ryP MofGV2FPT0WU
HuP-T4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwME[1PFYh|ryP MWLTRW5ITVJ?
HCT-15 NFHhZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm4[IVzUUN3ME2wMlA3PTl5IN88US=> MVfTRW5ITVJ?
NCCIT MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PubWlEPTB;MD6wOlYxPCEQvF2= NH3Zfm9USU6JRWK=
BOKU NYe1W|BWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;OTI06UUN3ME2wMlA3Pjd2IN88US=> MV\TRW5ITVJ?
FADU M2Pt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnpNlA{UUN3ME2wMlA3PzR3IN88US=> MW\TRW5ITVJ?
SUP-T1 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTHWJFKSzVyPUCuNFY4PiEQvF2= M3fpcXNCVkeHUh?=
L-363 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwME[5NFEh|ryP Mne2V2FPT0WU
KNS-81-FD MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPPTWM2OD1yLkC2PVE5KM7:TR?= MmT3V2FPT0WU
SU-DHL-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn31TWM2OD1yLkC2PVIh|ryP NUfydnZ[W0GQR1XS
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NCI-H1581 M3zKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPVTWM2OD1zLkO1Olg4KM7:TR?= NF7PPGJUSU6JRWK=
NCI-H748 M{f4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljOTWM2OD1zLkO1O|M5KM7:TR?= MXfTRW5ITVJ?
HCC1187 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X5OmlEPTB;MT61OVUzOiEQvF2= NE\P[2ZUSU6JRWK=
EoL-1-cell Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnZR2tKSzVyPUGuOVg5QDlizszN NG\OelhUSU6JRWK=
HuO-3N1 M2XWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwOEO0NVIh|ryP NX;ZTWpNW0GQR1XS
NCI-H1793 M2exRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fXbmlEPTB;MT64O|U6OyEQvF2= Mmf4V2FPT0WU
Caov-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnUNFdKSzVyPUKuNFA3OjVizszN MnfYV2FPT0WU
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SK-MEL-28 M1jsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfI[JZKSzVyPUKuNVgxQThizszN MWnTRW5ITVJ?
EM-2 NFzPNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLZOHBvUUN3ME2yMlIxOjl|IN88US=> NEHxO5lUSU6JRWK=
Mewo MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrp[2ZWUUN3ME2yMlIzOjZ3IN88US=> NI\OTplUSU6JRWK=
NCI-H720 MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP5TWM2OD1{LkK2OVg2KM7:TR?= M{\5fHNCVkeHUh?=
CAL-54 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKTWM2OD1{LkK2O|k2KM7:TR?= NILYVINUSU6JRWK=
MC116 M1zo[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\yTWM2OD1{LkO2N|k4KM7:TR?= NFjHdG9USU6JRWK=
DG-75 M2PnfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX6TWM2OD1{LkS4OVc3KM7:TR?= MW\TRW5ITVJ?
HCC1143 NE\ZbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv5TWM2OD1{LkWwOlU5KM7:TR?= M2O5OHNCVkeHUh?=
FTC-133 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrVT|ZpUUN3ME2yMlU{Pjh7IN88US=> M1e4eHNCVkeHUh?=
AsPC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;WVnBKSzVyPUKuOVM6OjlizszN MoHpV2FPT0WU
NCI-H889 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHiTHpbUUN3ME2yMlU3PzB4IN88US=> NWHnboRpW0GQR1XS
HT55 NYPKT|VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Hi[GlEPTB;Mj62NlAyQSEQvF2= MXrTRW5ITVJ?
UMC-11 NWH4eHVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PTfmlEPTB;Mj63PFcyPSEQvF2= NIXrSoZUSU6JRWK=
P12-ICHIKAWA NF;tfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwOEKwOFYh|ryP Mmj5V2FPT0WU
HCC1395 NXnYbVB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rKTGlEPTB;Mj65PFYxOiEQvF2= NFH6WJFUSU6JRWK=
D-283MED NVTrUIFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfmW3BCUUN3ME2zMlE5QTN5IN88US=> M3T5S3NCVkeHUh?=
COLO-800 NGPXfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy1N2VsUUN3ME2zMlM{QDl5IN88US=> NYrvSmNPW0GQR1XS
MFM-223 MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fOPGlEPTB;Mz6zOlA6PyEQvF2= NGrvV2VUSU6JRWK=
TE-5 M3HWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLfIRYUUN3ME20MlU3OTR5IN88US=> MVfTRW5ITVJ?
NCI-H209 NW[0XYpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfIUYZKSzVyPUSuO|g2PzJizszN MVzTRW5ITVJ?
SiHa NYKwfohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrnTWM2OD12Lkm1NlA{KM7:TR?= NULFRWlXW0GQR1XS
NCI-H1395 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LwS2lEPTB;NT6xNFY{OyEQvF2= Ml\UV2FPT0WU
A498 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnHTWM2OD13LkKxNlUyKM7:TR?= M{DhV3NCVkeHUh?=
ES5 M3TZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\1PGlEPTB;NT62NVE4QCEQvF2= MVjTRW5ITVJ?
MDA-MB-157 NXvHRYFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTVwNk[0OFMh|ryP MoHvV2FPT0WU
NCI-H1623 M2Xzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi5TWM2OD13LkizOVU3KM7:TR?= NUD0TpNIW0GQR1XS
RPMI-8866 NITWWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m5cmlEPTB;NT64OFc6OiEQvF2= M2HJNnNCVkeHUh?=
LC-1F M2T2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZwMEmyPVEh|ryP MlzBV2FPT0WU
TCCSUP MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHEWoNKSzVyPU[uOlA{PDlizszN MW\TRW5ITVJ?
TT M4[2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmKzTWM2OD16LkOzNFA6KM7:TR?= MnPuV2FPT0WU
NCI-H1838 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzCdZR6UUN3ME24MlUyPzNzIN88US=> Ml7mV2FPT0WU
NCI-H322M Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rpfWlEPTB;OT6xOlI5OSEQvF2= NFnNOFRUSU6JRWK=
NCI-H187 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTlwNUG4N|Uh|ryP MX\TRW5ITVJ?
SBC-1 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TKWGlEPTB;OT65N|Y2PiEQvF2= MYrTRW5ITVJ?
SCC-3 NYLDV|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\Dcm9TUUN3ME2xNE42Pjd7IN88US=> NULhUo9GW0GQR1XS
SW948 M323[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITSPZdKSzVyPUGwMlc2OTFizszN MYLTRW5ITVJ?
CPC-N Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7MTWM2OD1zMT6wNFch|ryP M37pOXNCVkeHUh?=
TGBC24TKB NHTQbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr3XlZKSzVyPUGzMlUzQSEQvF2= MmPxV2FPT0WU
NCI-H2452 M3\TbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF2LkezJO69VQ>? NUfjNYh2W0GQR1XS
Hs-578-T M3TEc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;LZ4xXUUN3ME2xPE42PzV7IN88US=> M{eybnNCVkeHUh?=
DV-90 MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPQWnZKSzVyPUG4Mlk6PDVizszN M3TOPHNCVkeHUh?=
NCI-H1563 M2jiUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjQeIxKSzVyPUG5Mlc5QDhizszN NYTTXVdlW0GQR1XS
SW780 NUP6WmJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJzLkGzNVgh|ryP MXHTRW5ITVJ?
NCI-H345 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjEeVJKSzVyPUKxMlg4PzlizszN MWrTRW5ITVJ?
LB771-HNC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJ{LkS4NVMh|ryP NH76W2RUSU6JRWK=
RT4 M1XZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeyW4lwUUN3ME2yN{4{Ojh{IN88US=> NX60b3VSW0GQR1XS
NCI-H82 NED1UYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJ|LkW1NlYh|ryP NUThO|dOW0GQR1XS
NCI-H524 NI\YSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ2LkO4NVIh|ryP MnPyV2FPT0WU
SNU-C1 NXfQfVhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ2LkmxNFUh|ryP M3;QfHNCVkeHUh?=
NCI-SNU-16 NHPkTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\6TWM2OD12OD6zNVQzKM7:TR?= MVzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID