Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 24 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778 ( click the link to review the publication )

Mol Cancer, 2011, 10:125

PubMed: 21962244 ( click the link to review the publication )

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418 ( click the link to review the publication )

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685 ( click the link to review the publication )

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393 ( click the link to review the publication )
J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909 ( click the link to review the publication )

PLoS One, 2014, 9(12):e114506

PubMed: 25503774 ( click the link to review the publication )

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175 ( click the link to review the publication )

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed: ( click the link to review the publication )

3 Customer Reviews

U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.
Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922 (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	M2m1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDTTo5KUUN3ME2wMlAxODF{NTFOwG0>	M4fWSHNCVkeHUh?=
MV-4-11	MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4G2cWlEPTB;MD6wNFA2PThizszN	MUPTRW5ITVJ?
NALM-6	M3y3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYmybYJYUUN3ME2wMlAxODh2MjFOwG0>	NIPxV\|RUSU6JRWK=
HOS	NHXsVpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTBwMECxN\|gh\|ryP	MnvIV2FPT0WU
HT-144	NX3iclhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NU\ZXJdpUUN3ME2wMlAxOTV3IN88US=>	NH3IcllUSU6JRWK=
SW1710	MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTBwMECxPFYh\|ryP	M3nROnNCVkeHUh?=
TE-8	Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLxOm56UUN3ME2wMlAxOjN5IN88US=>	NW[xSXBoW0GQR1XS
ES1	MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkfwTWM2OD1yLkCwNlY3KM7:TR?=	MmfaV2FPT0WU
CCF-STTG1	M3PId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVXzTIRrUUN3ME2wMlAxOjl5IN88US=>	M2XUO3NCVkeHUh?=
PSN1	MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTBwMECzNVgh\|ryP	M3rE[XNCVkeHUh?=
CAL-51	NEP2OlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4fwfGlEPTB;MD6wNFMzPSEQvF2=	M2TPfXNCVkeHUh?=
MCF7	NU\vS3lNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{HtcGlEPTB;MD6wNFM{PSEQvF2=	NWO1cIxZW0GQR1XS
SK-HEP-1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTBwMECzN\|Yh\|ryP	NH\vVXhUSU6JRWK=
LCLC-103H	MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVL6eYs4UUN3ME2wMlAxPDNizszN	M3rJ[HNCVkeHUh?=
HMV-II	M3vKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1HqVWlEPTB;MD6wNFQ1QSEQvF2=	MmXGV2FPT0WU
MES-SA	M1TRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MljYTWM2OD1yLkCwOFUzKM7:TR?=	MXfTRW5ITVJ?
SK-LMS-1	NGTOXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\nb2lEPTB;MD6wNFQ2QCEQvF2=	NF;GT4pUSU6JRWK=
639-V	M3rUZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm[1TWM2OD1yLkCwOFg2KM7:TR?=	MVzTRW5ITVJ?
SIG-M5	NGLvZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTBwMEC0PFkh\|ryP	NHHtfHNUSU6JRWK=
LOUCY	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\kb49KSzVyPUCuNFA2ODVizszN	MWTTRW5ITVJ?
HSC-2	M{X6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XqeWlEPTB;MD6wNFUyQCEQvF2=	MnLmV2FPT0WU
EW-13	MkLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUC3NFkzUUN3ME2wMlAxPTF6IN88US=>	NYLsZYVvW0GQR1XS
RT-112	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MniwTWM2OD1yLkCwOVM2KM7:TR?=	NIqyfWZUSU6JRWK=
NKM-1	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYW5dWE6UUN3ME2wMlAxPTR5IN88US=>	M2m4OHNCVkeHUh?=
KYSE-180	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nUVmlEPTB;MD6wNFU5PiEQvF2=	NGnBOINUSU6JRWK=
SW1783	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTBwMEC1PVEh\|ryP	M3PyNXNCVkeHUh?=
A431	NITySohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn2zTWM2OD1yLkCwOlA4KM7:TR?=	MVLTRW5ITVJ?
SK-OV-3	M4O1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{f4d2lEPTB;MD6wNFY{KM7:TR?=	MlroV2FPT0WU
RPMI-7951	NHPK[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjMRoM6UUN3ME2wMlAxPjNzIN88US=>	MUXTRW5ITVJ?
Capan-2	NXLRSoxFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1y3eWlEPTB;MD6wNFY{QCEQvF2=	M3LzOHNCVkeHUh?=
HSC-3	NVXidYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnewTWM2OD1yLkCwOlQyKM7:TR?=	NV7tWnNVW0GQR1XS
786-0	MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTBwMEC2OlMh\|ryP	NUT3dHVZW0GQR1XS
Daoy	NVj1OIZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{Tpd2lEPTB;MD6wNFY6PSEQvF2=	NXf1PZJ4W0GQR1XS
KGN	M3jKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TObWlEPTB;MD6wNFcxOyEQvF2=	M2rDTHNCVkeHUh?=
EW-16	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\tTWM2OD1yLkCwO\|Q6KM7:TR?=	NUXyeYM3W0GQR1XS
EW-7	MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTtTWM2OD1yLkCwO\|U1KM7:TR?=	NYX4N2hZW0GQR1XS
IGROV-1	NXHrbmRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfKbnp[UUN3ME2wMlAxQDF2IN88US=>	NIHqV3NUSU6JRWK=
8505C	MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEX3OHVKSzVyPUCuNFA5OjFizszN	M1rmNnNCVkeHUh?=
RKO	NUPsO49xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXPrRnU{UUN3ME2wMlAxQDJ4IN88US=>	NX[1WZRTW0GQR1XS
GDM-1	NYXYe2c1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrkZ2pKSzVyPUCuNFA5PCEQvF2=	NXzrRWZIW0GQR1XS
IST-MEL1	M3jyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWrwRmlnUUN3ME2wMlAxQDV{IN88US=>	Mk\1V2FPT0WU
RPMI-6666	MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3iwPWlEPTB;MD6wNFg2OiEQvF2=	NFvP[YtUSU6JRWK=
SNG-M	NYHl[HdzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvFUGJKSzVyPUCuNFA5PTZizszN	M3TiOXNCVkeHUh?=
KS-1	Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTBwMEC4OVkh\|ryP	MnPxV2FPT0WU
RXF393	NXfZenl2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmjlTWM2OD1yLkCwPFYh\|ryP	M4XtVXNCVkeHUh?=
CAL-12T	NFLObHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\mTWM2OD1yLkCwPVIzKM7:TR?=	M4DWeXNCVkeHUh?=
BFTC-905	MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFfDbFhKSzVyPUCuNFA6OzhizszN	M4\IRXNCVkeHUh?=
SK-MES-1	NYjVdJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkK1TWM2OD1yLkCwPVQ2KM7:TR?=	M{H1UnNCVkeHUh?=
BB30-HNC	NXjMcYt4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPyT29KSzVyPUCuNFA6PTJizszN	NHPWfm9USU6JRWK=
AN3-CA	NXLYTHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYX6VW9CUUN3ME2wMlAyODF5IN88US=>	MmTTV2FPT0WU
EFO-27	M4LnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYWxPVFQUUN3ME2wMlAyODF5IN88US=>	MXzTRW5ITVJ?
G-401	NG\jSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnv6TWM2OD1yLkCxNFI2KM7:TR?=	NXu5UYRQW0GQR1XS
BPH-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTBwMEGwN{DPxE1?	NYP1RYVJW0GQR1XS
NCI-H727	MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHvuNFdKSzVyPUCuNFExOyEQvF2=	MnfyV2FPT0WU
SNU-423	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXLOUYFOUUN3ME2wMlAyODV\|IN88US=>	NHzieZNUSU6JRWK=
KYSE-270	NELtS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7KTWM2OD1yLkCxNFU6KM7:TR?=	M4K5S3NCVkeHUh?=
AGS	NFjscIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYf6XpZ5UUN3ME2wMlAyODZzIN88US=>	NVL1b2NwW0GQR1XS
NCI-H2228	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTBwMEGwOlQh\|ryP	MXTTRW5ITVJ?
SW954	M4KxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo[2TWM2OD1yLkCxNFcyKM7:TR?=	NYX6O5lGW0GQR1XS
769-P	NVOyVIRHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXlO2JKSzVyPUCuNFExPzNizszN	NWPvb2Z3W0GQR1XS
BB49-HNC	M4H6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmK2TWM2OD1yLkCxNFc4KM7:TR?=	NUPzWJdGW0GQR1XS
IA-LM	NIrtPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7lTWM2OD1yLkCxNFg3KM7:TR?=	MV7TRW5ITVJ?
NB69	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTBwMEGxNFIh\|ryP	NV\UTIdEW0GQR1XS
C8166	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fqdGlEPTB;MD6wNVEzQSEQvF2=	NXv2NlF4W0GQR1XS
NCI-H1299	M17zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMEGxOVQh\|ryP	M2DUN3NCVkeHUh?=
YKG-1	MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HzXWlEPTB;MD6wNVE3KM7:TR?=	MmrNV2FPT0WU
PANC-03-27	Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTBwMEGxOlIh\|ryP	NFLpXlVUSU6JRWK=
YT	MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3zOUWlEPTB;MD6wNVE4QSEQvF2=	MYDTRW5ITVJ?
CAL-85-1	NH\vOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{XlVGlEPTB;MD6wNVE6OiEQvF2=	Mon4V2FPT0WU
GT3TKB	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NELaW4lKSzVyPUCuNFEzODJizszN	MWHTRW5ITVJ?
BB65-RCC	NIC3bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTBwMEGyNFQh\|ryP	MoXmV2FPT0WU
ES6	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{Wze2lEPTB;MD6wNVI3OSEQvF2=	M3jBWHNCVkeHUh?=
MHH-ES-1	NWDvZZhXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIm0cnpKSzVyPUCuNFEzPjNizszN	MUfTRW5ITVJ?
QIMR-WIL	M4DnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXuSpRKSzVyPUCuNFEzPjlizszN	NISyVVJUSU6JRWK=
SNU-C2B	NVPtNJhFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTBwMEGyO\|Ih\|ryP	NHW2cmdUSU6JRWK=
OCI-AML2	MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MojmTWM2OD1yLkCxNlgyKM7:TR?=	MmjyV2FPT0WU
DU-145	NH;4dmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLpTWM2OD1yLkCxNlkh\|ryP	Mki3V2FPT0WU
SW982	NX;l[lNkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGLKT\|JKSzVyPUCuNFEzQTNizszN	NYOxRVVPW0GQR1XS
MFH-ino	NWKyNY86T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3r2Z2lEPTB;MD6wNVI6OyEQvF2=	MkDGV2FPT0WU
A427	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIm2OZJKSzVyPUCuNFEzQTlizszN	M{fYV3NCVkeHUh?=
LCLC-97TM1	NIrrVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\KTWM2OD1yLkCxN{DPxE1?	NUCyXmJuW0GQR1XS
AM-38	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX7pXplOUUN3ME2wMlAyOzB{IN88US=>	MonOV2FPT0WU
K5	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTBwMEGzNFgh\|ryP	MojLV2FPT0WU
T84	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXjeI5KSzVyPUCuNFE{OzFizszN	MnvZV2FPT0WU
TE-15	M1yxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1HPfWlEPTB;MD6wNVM{PiEQvF2=	NIPRc4NUSU6JRWK=
NCI-H460	MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDPdY5KSzVyPUCuNFE{OzZizszN	M{DVTXNCVkeHUh?=
NTERA-S-cl-D1	NEXVVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7JTWM2OD1yLkCxN\|M6KM7:TR?=	MXjTRW5ITVJ?
KYSE-450	NHjhcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUDLbYVsUUN3ME2wMlAyOzR7IN88US=>	NVy4[FA5W0GQR1XS
H4	NGSzcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTBwMEGzOlYh\|ryP	Ml32V2FPT0WU
LC-2-ad	NVfse4c5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrZ[VFKSzVyPUCuNFE{PyEQvF2=	MV;TRW5ITVJ?
GAMG	NVy0NIQyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPuWpFGUUN3ME2wMlAyOzdzIN88US=>	NXLNeYFOW0GQR1XS
TK10	NVu1bJd7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDw[4VCUUN3ME2wMlAyOzh{IN88US=>	NIO0[4RUSU6JRWK=
NCI-H2122	M{PwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlqxTWM2OD1yLkCxN\|g1KM7:TR?=	NVfvTWQxW0GQR1XS
KM12	NW\LPJdFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTBwMEGzPVkh\|ryP	NYrOSHBrW0GQR1XS
CAL-39	MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3zWdGlEPTB;MD6wNVQzKM7:TR?=	NGnzVYZUSU6JRWK=
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MKN28	NV;MWFkxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXT4dYtTUUN3ME2wMlA{ODF{IN88US=>	NGr3NWlUSU6JRWK=
SW837	NXXuNWZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWnzUmx{UUN3ME2wMlA{ODF2IN88US=>	NIqzWIlUSU6JRWK=
no-10	NFjjVGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NInBXFZKSzVyPUCuNFMxOTZizszN	MkXPV2FPT0WU
BC-3	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWjTZlByUUN3ME2wMlA{ODF6IN88US=>	M3fxO3NCVkeHUh?=
no-11	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MofLTWM2OD1yLkCzNFQ5KM7:TR?=	MoXtV2FPT0WU
8305C	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV7N[W1sUUN3ME2wMlA{ODd{IN88US=>	MYPTRW5ITVJ?
COLO-679	M1PLPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLxSGh1UUN3ME2wMlA{OTB5IN88US=>	NILKU4JUSU6JRWK=
CESS	Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4HCcWlEPTB;MD6wN\|EzKM7:TR?=	MlvFV2FPT0WU
BFTC-909	NXW4WZdKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2TwSGlEPTB;MD6wN\|EzPSEQvF2=	M17WdXNCVkeHUh?=
MZ2-MEL	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{TkTGlEPTB;MD6wN\|E4PyEQvF2=	M3qwXHNCVkeHUh?=
SW872	NXXwRYR{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWHKOHk2UUN3ME2wMlA{OjF5IN88US=>	M2XIS3NCVkeHUh?=
LB831-BLC	M2nlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUTJR\|UxRTBwMEOyNVkh\|ryP	M4e1NHNCVkeHUh?=
SK-UT-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwMEOyNlEh\|ryP	Mkf3V2FPT0WU
NCI-H1734	NFTVO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHkdmx[UUN3ME2wMlA{OjNizszN	NHL3[\|VUSU6JRWK=
OVCAR-8	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXfJR\|UxRTBwMEOyPFEh\|ryP	MWXTRW5ITVJ?
NCI-H2087	NXLWXFRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIO5b25KSzVyPUCuNFMzQDlizszN	MUHTRW5ITVJ?
U-87-MG	NYrhWGtPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\rR2lEPTB;MD6wN\|I6KM7:TR?=	MYjTRW5ITVJ?
BC-1	NH3NWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTBwMEOzOlch\|ryP	NWLqXVBrW0GQR1XS
ES7	MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DmUmlEPTB;MD6wN\|M4PCEQvF2=	NHTZO2dUSU6JRWK=
Daudi	MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGCyXHFKSzVyPUCuNFM{PzZizszN	MW\TRW5ITVJ?
RS4-11	NHr4PIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTBwMEOzPFMh\|ryP	MmXjV2FPT0WU
JiyoyeP-2003	NYDwSZlzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMEOzPFgh\|ryP	M4jRRnNCVkeHUh?=
BL-70	NVfjUZVlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIXwbZdKSzVyPUCuNFM{QDlizszN	MoW1V2FPT0WU
OS-RC-2	NX;6NZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwMEOzPVYh\|ryP	M{\p[HNCVkeHUh?=
SF268	NGTZWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2LzVmlEPTB;MD6wN\|QxOSEQvF2=	NF6zTHhUSU6JRWK=
BV-173	NGrPO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHPCOVhKSzVyPUCuNFM1OjZizszN	M4\mUXNCVkeHUh?=
DMS-273	Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPFSnJKSzVyPUCuNFM1PzlizszN	MXzTRW5ITVJ?
22RV1	MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVv0dpc1UUN3ME2wMlA{PTB5IN88US=>	NWLaWXhoW0GQR1XS
ES8	M1vubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlT0TWM2OD1yLkCzOVM5KM7:TR?=	MoizV2FPT0WU
KYSE-150	M{TjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MY\JR\|UxRTBwMEO2NFgh\|ryP	MX7TRW5ITVJ?
HCC1569	NVmzbpJHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\IO3VKSzVyPUCuNFM3ODhizszN	NYHNbldWW0GQR1XS
NB5	M3T5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmXBTWM2OD1yLkCzOlE{KM7:TR?=	MVLTRW5ITVJ?
G-402	NYXXXYxwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEPF[W1KSzVyPUCuNFM3OTRizszN	NHPxW2hUSU6JRWK=
NCI-H1693	NVrIcJp6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEK3OYhKSzVyPUCuNFM3OTdizszN	NEfOUHlUSU6JRWK=
LB2241-RCC	M{nOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoiwTWM2OD1yLkCzOlQzKM7:TR?=	M4DkS3NCVkeHUh?=
KP-4	NEXUWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlvZTWM2OD1yLkCzOlY{KM7:TR?=	M{e3WnNCVkeHUh?=
ML-2	MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLE[Fh2UUN3ME2wMlA{PjdzIN88US=>	NIC3OWpUSU6JRWK=
KU812	M4LyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUj3O2dKUUN3ME2wMlA{Pjh2IN88US=>	NF;lSpFUSU6JRWK=
LS-411N	NHHIc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnSd\|h2UUN3ME2wMlA{PzNzIN88US=>	MXrTRW5ITVJ?
OAW-42	M{jt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwMEO3OFch\|ryP	M33HfXNCVkeHUh?=
HCC38	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml3iTWM2OD1yLkCzO\|cyKM7:TR?=	M2nlVXNCVkeHUh?=
Ca-Ski	MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jxSmlEPTB;MD6wN\|c5PCEQvF2=	M{nJWnNCVkeHUh?=
Calu-3	NHXGNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4nzdGlEPTB;MD6wN\|c5QSEQvF2=	NUnXbGxpW0GQR1XS
KYSE-70	NYjIO3pzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\aVHhwUUN3ME2wMlA{QDF{IN88US=>	Ml35V2FPT0WU
D-392MG	M13UN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVW0NWFqUUN3ME2wMlA{QDR{IN88US=>	M33iT3NCVkeHUh?=
OVCAR-4	MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTBwMEO4OVgh\|ryP	MUTTRW5ITVJ?
Detroit562	MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrVTWM2OD1yLkCzPFczKM7:TR?=	NXPIUnRvW0GQR1XS
HEL	MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnPFTWM2OD1yLkCzPFkyKM7:TR?=	NWi2WHJsW0GQR1XS
MONO-MAC-6	NWq0WG9[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFjqWIFKSzVyPUCuNFM5QTNizszN	NF3tZYlUSU6JRWK=
LoVo	NVPHTWZwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml64TWM2OD1yLkCzPVM{KM7:TR?=	MXTTRW5ITVJ?
U-2-OS	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoHxTWM2OD1yLkCzPVM2KM7:TR?=	M3H4dXNCVkeHUh?=
A172	NUiwdoFRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfOTWM2OD1yLkCzPVUh\|ryP	NVrBT\|RjW0GQR1XS
OCUB-M	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIHVO\|FKSzVyPUCuNFM6PjFizszN	NF\EW4VUSU6JRWK=
SW48	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGO5e5hKSzVyPUCuNFQxOzFizszN	NWrxcY1uW0GQR1XS
HC-1	M2T6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\aUGlEPTB;MD6wOFA3QSEQvF2=	NIHmV45USU6JRWK=
KOSC-2	M2C5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTJTWM2OD1yLkC0NVEh\|ryP	NHzwUYNUSU6JRWK=
HDLM-2	M1vnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGL4ZphKSzVyPUCuNFQyOTRizszN	NVrHeIVpW0GQR1XS
CTV-1	NFnmZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRTBwMESxNVYh\|ryP	M1j6T3NCVkeHUh?=
SH-4	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIH6VZVKSzVyPUCuNFQyPDFizszN	NF;sfoFUSU6JRWK=
SW756	NVfJXIFsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYLJR\|UxRTBwMESxOVch\|ryP	M2fEZ3NCVkeHUh?=
GCT	M4i2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{XmXWlEPTB;MD6wOFE3OSEQvF2=	M1\Sd3NCVkeHUh?=
CHL-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnm1TWM2OD1yLkC0NVY6KM7:TR?=	MXTTRW5ITVJ?
LAMA-84	MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXtTFdKSzVyPUCuNFQyPzFizszN	NH7i[m9USU6JRWK=
LS-1034	NU\SOXhRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\DUHFsUUN3ME2wMlA1OTlzIN88US=>	NIS3WpFUSU6JRWK=
NCI-H358	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH7OSIJKSzVyPUCuNFQzOTJizszN	MYLTRW5ITVJ?
NB13	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHGxOFJKSzVyPUCuNFQzOjdizszN	MYPTRW5ITVJ?
TE-9	NXPnV3BIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXzYXo5YUUN3ME2wMlA1OjN5IN88US=>	MXvTRW5ITVJ?
OE33	NFPTOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTBwMESyOFEh\|ryP	NG\rfIdUSU6JRWK=
CAL-120	M3\TRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7wTWM2OD1yLkC0NlQyKM7:TR?=	MUjTRW5ITVJ?
DJM-1	NEXzWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIG3OJZKSzVyPUCuNFQzPzJizszN	M{S5TXNCVkeHUh?=
SK-MEL-24	NFrO[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTBwMESyPFMh\|ryP	NGKzVWhUSU6JRWK=
VA-ES-BJ	NV\2SWl[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFfuOIpKSzVyPUCuNFQzQTJizszN	MnXLV2FPT0WU
MMAC-SF	NIXTXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2TGfmlEPTB;MD6wOFI6PyEQvF2=	NHLSS\|RUSU6JRWK=
MZ7-mel	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUO3fopmUUN3ME2wMlA1OzNizszN	MV\TRW5ITVJ?
BxPC-3	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTBwMESzOFEh\|ryP	MXLTRW5ITVJ?
HT-29	NEXJNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFTrVJNKSzVyPUCuNFQ{PTdizszN	NFL0UHVUSU6JRWK=
SK-MEL-30	M2DufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDETWM2OD1yLkC0N\|YzKM7:TR?=	M2\SUHNCVkeHUh?=
CAL-33	NFv5O5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXzTWM2OD1yLkC0N\|c2KM7:TR?=	MkfZV2FPT0WU
COLO-680N	NWDsXo12T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1j1fGlEPTB;MD6wOFQxPyEQvF2=	MWHTRW5ITVJ?
NH-12	MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTBwMES0OEDPxE1?	NY\GfIxVW0GQR1XS
HCC1937	NV[3UXpsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH;ZT5RKSzVyPUCuNFQ1PTZizszN	M13BVHNCVkeHUh?=
IMR-5	NXLqSXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvRTWM2OD1yLkC0OFkh\|ryP	MYTTRW5ITVJ?
MC-CAR	NXfkTYpST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUjic4Z6UUN3ME2wMlA1PTZ7IN88US=>	NETTOGVUSU6JRWK=
NCI-H747	NG\xZ5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfYbXd[UUN3ME2wMlA1PTdizszN	M3PaRXNCVkeHUh?=
NCI-H1792	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1HsZ2lEPTB;MD6wOFU5OSEQvF2=	NILMNXpUSU6JRWK=
SW13	M2fCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXO0U5BFUUN3ME2wMlA1PTlizszN	M16yfHNCVkeHUh?=
MLMA	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGfhW21KSzVyPUCuNFQ3ODlizszN	MnTkV2FPT0WU
U251	NGfKWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml;kTWM2OD1yLkC0O\|Y{KM7:TR?=	NHnBeYNUSU6JRWK=
U031	NHvzXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvrXHdKSzVyPUCuNFQ4PzFizszN	MWrTRW5ITVJ?
ME-180	MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrpTWM2OD1yLkC0O\|gzKM7:TR?=	NEC2[WZUSU6JRWK=
SK-MEL-3	MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nEXmlEPTB;MD6wOFgxOiEQvF2=	MXzTRW5ITVJ?
MOLT-4	NYDsO4FXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjGTWM2OD1yLkC0PFA{KM7:TR?=	M3i0cHNCVkeHUh?=
PF-382	MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjw[VJEUUN3ME2wMlA1QDJ4IN88US=>	NEW4bIFUSU6JRWK=
NUGC-3	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUPJR\|UxRTBwMES4Nlch\|ryP	MmXwV2FPT0WU
NCI-H1417	MnXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfMeVV2UUN3ME2wMlA1QDlizszN	Ml7XV2FPT0WU
COLO-205	M4D1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUfsPFlnUUN3ME2wMlA1QTF7IN88US=>	MnPxV2FPT0WU
TE-441-T	NHH6TFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXWzTGhjUUN3ME2wMlA1QTNizszN	MVjTRW5ITVJ?
MKN1	NEX4SZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTBwMES5N{DPxE1?	NXq5NVB6W0GQR1XS
UM-UC-3	M{DzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\uTWM2OD1yLkC0PVUh\|ryP	NH3le2tUSU6JRWK=
SF126	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYjLSpRMUUN3ME2wMlA2ODFizszN	MWXTRW5ITVJ?
LB1047-RCC	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXq3dnhVUUN3ME2wMlA2ODNzIN88US=>	NYnjXWY3W0GQR1XS
A253	M3\veGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF7DfYFKSzVyPUCuNFUxPTJizszN	M{jHSHNCVkeHUh?=
NCI-H1963	NF7iWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHMTWM2OD1yLkC1NVc3KM7:TR?=	MVPTRW5ITVJ?
VM-CUB-1	M1XRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUHxOpNqUUN3ME2wMlA2OzFzIN88US=>	MoD4V2FPT0WU
T-24	M{nwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NG\DO\|BKSzVyPUCuNFU{QDRizszN	NH75TIRUSU6JRWK=
K-562	NHnXbllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV34blZ1UUN3ME2wMlA2Ozh5IN88US=>	M4fDNHNCVkeHUh?=
ARH-77	M3XJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHf3dIxKSzVyPUCuNFU{QTVizszN	MWrTRW5ITVJ?
CA46	NHjxOItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTBwMEW0N{DPxE1?	MkT3V2FPT0WU
HCC70	NWXIUo1YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWTJR\|UxRTBwMEW0OVIh\|ryP	NYP4[YVvW0GQR1XS
ST486	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnTHTWM2OD1yLkC1OVI2KM7:TR?=	NGe0O\|lUSU6JRWK=
COLO-741	M3XYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfRNXBKSzVyPUCuNFU2OzFizszN	MoLnV2FPT0WU
SK-PN-DW	M{\BcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlO2TWM2OD1yLkC1OVg5KM7:TR?=	M1rnTHNCVkeHUh?=
BL-41	MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHLFV\|JKSzVyPUCuNFU2QTZizszN	M2HvN3NCVkeHUh?=
D-263MG	M{j4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVP1[2JCUUN3ME2wMlA2Pjh\|IN88US=>	MlTHV2FPT0WU
KE-37	M{fQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3e0emlEPTB;MD6wOVY5OyEQvF2=	MnPCV2FPT0WU
LU-134-A	NV3YWHRwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV;jXXR1UUN3ME2wMlA2PzF3IN88US=>	M4Lv[nNCVkeHUh?=
HCC2157	MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF36OXpKSzVyPUCuNFU4OzNizszN	M4i3VXNCVkeHUh?=
GAK	M2q1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTBwMEW3N\|Qh\|ryP	MUXTRW5ITVJ?
IST-SL2	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MU\JR\|UxRTBwMEW3OFMh\|ryP	NXjNWolUW0GQR1XS
KMOE-2	NEfUNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml3WTWM2OD1yLkC1O\|Q6KM7:TR?=	MUTTRW5ITVJ?
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SCC-25	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoixTWM2OD1yLkGzOVg5KM7:TR?=	NHLQfnRUSU6JRWK=
NCI-H1755	NIfIN5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIrWXZBKSzVyPUCuNVM5OjdizszN	M2fTVXNCVkeHUh?=
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KARPAS-422	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFLRfo9KSzVyPUCuNVQxOzdizszN	MWDTRW5ITVJ?
OVCAR-3	NWm0PWJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M37iZ2lEPTB;MD6xOFA4QCEQvF2=	MnPLV2FPT0WU
NCI-H1092	M3joZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4nBZmlEPTB;MD6xOFExOSEQvF2=	M{PEcXNCVkeHUh?=
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HD-MY-Z	NFrMb\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTpTWM2OD1yLkG0OFI6KM7:TR?=	MXfTRW5ITVJ?
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NCI-H1522	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M174XWlEPTB;MD6xOFc5PyEQvF2=	NUTOUJlFW0GQR1XS
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RCM-1	M1Lhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTBwMUW2PEDPxE1?	M2\3WXNCVkeHUh?=
COR-L279	NUe2OphnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2TrNWlEPTB;MD6xOVg{PiEQvF2=	M2LVXXNCVkeHUh?=
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KLE	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTBwMU[xOlkh\|ryP	Mn:0V2FPT0WU
NCI-H2170	MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\DR3lHUUN3ME2wMlE3OzB2IN88US=>	NV6yRnNPW0GQR1XS
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CAL-72	NFvCbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWLJR\|UxRTBwMU[1PUDPxE1?	NIDZeYNUSU6JRWK=
K052	M{DNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3m3cGlEPTB;MD6xO\|A3OSEQvF2=	Ml\3V2FPT0WU
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MDA-MB-134-VI	MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;TbmRVUUN3ME2wMlE4OzZ5IN88US=>	NWC0[oFuW0GQR1XS
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NCI-H1573	NXv6Tpp1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlS2TWM2OD1yLkG3Olc5KM7:TR?=	MmTDV2FPT0WU
SKG-IIIa	MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlPjTWM2OD1yLkG3PFA4KM7:TR?=	M13ZXnNCVkeHUh?=
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NCI-H2171	M2HaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMUi2OFkh\|ryP	M13YfHNCVkeHUh?=
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LU-65	NHixTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmfrTWM2OD1yLkKwNlEyKM7:TR?=	MmO2V2FPT0WU
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NCI-H2196	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLCTWM2OD1yLkKxO\|Q4KM7:TR?=	MV3TRW5ITVJ?
M14	NWjCT5l1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHftVJFKSzVyPUCuNlE5ODNizszN	MofLV2FPT0WU
NCI-H1436	M4nKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmLHTWM2OD1yLkKxPFI3KM7:TR?=	NH3MdJZUSU6JRWK=
EB-3	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLiZZNPUUN3ME2wMlIzOzd4IN88US=>	MmPTV2FPT0WU
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KARPAS-299	NFr6R2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\xTGc1UUN3ME2wMlIzQTl2IN88US=>	NYjFWFhTW0GQR1XS
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NCI-H838	NGKx[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1SydmlEPTB;MD6yN\|cyPCEQvF2=	NE[zOHlUSU6JRWK=
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NCI-H2141	M2TmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTBwMkO4OFEh\|ryP	NW\idZRSW0GQR1XS
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NCI-H23	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfaU5B[UUN3ME2wMlI1ODV7IN88US=>	M3LoZnNCVkeHUh?=
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CAL-148	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFLrWJVKSzVyPUCuNlQzQDJizszN	NH7zdI9USU6JRWK=
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CAKI-1	M1G4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTBwMkWwPFYh\|ryP	NYLl[\|M3W0GQR1XS
MHH-NB-11	NIfNb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnPKTWM2OD1yLkK1N\|Uh\|ryP	NVrCTnZxW0GQR1XS
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NCI-H69	NXywSlZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX\JR\|UxRTBwMkeyNFEh\|ryP	MVnTRW5ITVJ?
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NCI-H1618	NIHQNpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn;YTWM2OD1yLkK3OVEh\|ryP	NH\zXHFUSU6JRWK=
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NCI-H1694	NE\m[\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4nUdWlEPTB;MD6yO\|c{OyEQvF2=	NFfufmNUSU6JRWK=
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NCI-H510A	M121OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkHqTWM2OD1yLkK5N\|A1KM7:TR?=	Mn;vV2FPT0WU
Mo-T	MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3ldpliUUN3ME2wMlI6OzNzIN88US=>	NHrueGdUSU6JRWK=
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NCI-H28	MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1jhXWlEPTB;MD6yPVg{PyEQvF2=	NI\KSYdUSU6JRWK=
NCI-H446	M{jTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWrZclZTUUN3ME2wMlI6QTJzIN88US=>	NUHWU2syW0GQR1XS
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BT-20	MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGHTR5ZKSzVyPUCuN\|ExQTlizszN	M3nMfXNCVkeHUh?=
KP-N-YN	NX\S[lNrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTBwM{GxNVgh\|ryP	NIX1WYNUSU6JRWK=
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HPAF-II	NHHlSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\acXFKSzVyPUCuOFEyOTdizszN	MWPTRW5ITVJ?
NCI-H1882	NUHt[ZNWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{TrfGlEPTB;MD60NVc5PCEQvF2=	MV;TRW5ITVJ?
JVM-2	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml7hTWM2OD1yLkS0OFAyKM7:TR?=	Mly0V2FPT0WU
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MHH-CALL-2	NV\1SnhnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUf3fnVTUUN3ME2wMlQ1QDNizszN	MYDTRW5ITVJ?
NCI-H716	NHTzPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPLTWM2OD1yLkS0PFQ5KM7:TR?=	NEj1c3FUSU6JRWK=
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RT4	M4DLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYi5OJU1UUN3ME2yN{4{Ojh{IN88US=>	NF3XdVJUSU6JRWK=
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NCI-SNU-16	NFH3RolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTR6LkOxOFIh\|ryP	NVHsZYN6W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	+ Expand Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	+ Expand Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	+ Expand Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products4

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

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Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)