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Luminespib (NVP-AUY922)
Synonyms: AUY-922, VER-52296
Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Luminespib (NVP-AUY922) Chemical Structure
CAS No. 747412-49-3
Purity & Quality Control
Batch:
Purity:
99.97%
99.97
Luminespib (NVP-AUY922) Related Products
| Related Targets | HSP40 HSP70 HSP90 HSP105 HSF1 | Click to Expand |
|---|---|---|
| Related Products | Tanespimycin (17-AAG) Elesclomol (STA-4783) Ganetespib (STA-9090) Alvespimycin (17-DMAG) HCl VER155008 BIIB021 Onalespib (AT13387) NVP-BEP800 KRIBB11 SNX-2112 HA15 Zelavespib (PU-H71) HSP990 (NVP-HSP990) NMS-E973 Apoptozole XL888 PF-04929113 (SNX-5422) KNK437 Teprenone TRC051384 VER-50589 Rocaglamide VER-49009 Pimitespib (TAS-116) JG98 DTHIB KW-2478 | Click to Expand |
| Related Compound Libraries | Kinase Inhibitor Library Angiogenesis Related compound Library TGF-beta/Smad compound library Cytoskeletal Signaling Pathway Compound Library Anti-Cardiovascular Disease Compound Library | Click to Expand |
Signaling Pathway
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| NCI-SNU-16 | Growth Inhibition Assay | IC50=48.3142 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=24.9105 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=24.3812 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=23.5526 μM | SANGER | |||
| RT4 | Growth Inhibition Assay | IC50=23.3282 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=22.4813 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=21.1318 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=21.8779 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=19.7888 μM | SANGER | |||
| DV-90 | Growth Inhibition Assay | IC50=18.9945 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=18.5759 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=14.73 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=13.529 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=10.7511 μM | SANGER | |||
| CPC-N | Growth Inhibition Assay | IC50=11.007 μM | SANGER | |||
| SCC-3 | Growth Inhibition Assay | IC50=10.5679 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=9.93656 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=9.51835 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=8.51731 μM | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | IC50=9.16281 μM | SANGER | |||
| TT | Growth Inhibition Assay | IC50=8.33009 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=6.60349 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=6.09291 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=5.84792 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=5.83556 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=5.66443 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=5.61178 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=5.21251 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=5.10633 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=4.95203 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=4.78572 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=4.56147 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=3.36097 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=3.33897 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=3.18937 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=2.98602 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=2.82046 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=2.62019 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=2.78715 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=2.53929 μM | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | IC50=2.56706 μM | SANGER | |||
| HCC1143 | Growth Inhibition Assay | IC50=2.50658 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=2.53689 μM | SANGER | |||
| DG-75 | Growth Inhibition Assay | IC50=2.48576 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=2.36397 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=2.26795 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=2.26585 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=2.20293 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=2.22265 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=2.18098 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=2.0792 μM | SANGER | |||
| Caov-3 | Growth Inhibition Assay | IC50=2.00625 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=1.83412 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.87593 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=1.55522 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=1.58889 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=1.35738 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=1.35687 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=1.33339 μM | SANGER | |||
| TALL-1 | Growth Inhibition Assay | IC50=1.25165 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=1.20595 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=1.18349 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=1.1542 μM | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | IC50=1.10766 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=1.0693 μM | SANGER | |||
| NCI-H2227 | Growth Inhibition Assay | IC50=1.04981 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.99379 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=1.04657 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.8942 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.90304 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.85115 μM | SANGER | |||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=0.88475 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.81339 μM | SANGER | |||
| SNU-475 | Growth Inhibition Assay | IC50=0.79202 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.79925 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=0.77975 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=0.78831 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=0.77845 μM | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | IC50=0.76903 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.74868 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=0.71918 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.7436 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=0.71719 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.70229 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.67952 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.67335 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=0.65092 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=0.64726 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.63152 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.60435 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.57313 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.55984 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=0.55211 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.54117 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=0.52207 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.53869 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=0.51457 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=0.50367 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=0.4803 μM | SANGER | |||
| UACC-812 | Growth Inhibition Assay | IC50=0.46776 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.45145 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=0.44848 μM | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=0.4483 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=0.44528 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=0.44401 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=0.41784 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.41117 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=0.411 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.40872 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=0.36691 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=0.37637 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=0.3612 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.35715 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=0.35124 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.34923 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.34452 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=0.33389 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.33132 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.32348 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.31118 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=0.31099 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.31064 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=0.30639 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.29921 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=0.30089 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29837 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=0.29331 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.29431 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.2881 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.29304 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=0.28383 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=0.28174 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=0.27733 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.27613 μM | SANGER | |||
| NCI-H1618 | Growth Inhibition Assay | IC50=0.2751 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.27249 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.2722 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=0.27201 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.26905 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=0.26677 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=0.26603 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=0.2593 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.2535 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.25086 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=0.24694 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=0.24612 μM | SANGER | |||
| EFE-184 | Growth Inhibition Assay | IC50=0.24597 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=0.24282 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.24239 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24059 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=0.24014 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.23731 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=0.23841 μM | SANGER | |||
| NCI-H838 | Growth Inhibition Assay | IC50=0.23714 μM | SANGER | |||
| IM-9 | Growth Inhibition Assay | IC50=0.23476 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=0.22865 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=0.22994 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.22708 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=0.22376 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=0.22566 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=0.21826 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=0.21747 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.21803 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.20997 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=0.20211 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.2064 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.19975 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=0.19863 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.19893 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.19748 μM | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | IC50=0.18649 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=0.18696 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.18569 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=0.186 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.18493 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=0.1797 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.17807 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.17883 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.17678 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.17486 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=0.1738 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.17257 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=0.17367 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.17246 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.1716 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=0.17061 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.17114 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=0.1659 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=0.16471 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=0.16169 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.16304 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.15899 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=0.15836 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=0.15413 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.1568 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=0.15333 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=0.15218 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.14942 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.15169 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=0.14787 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.1448 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.14772 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=0.14472 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.14429 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=0.14426 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.14201 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.14101 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.14078 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=0.14037 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.13827 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=0.13965 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.13469 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=0.13588 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=0.13444 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.1343 μM | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | IC50=0.12869 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=0.13177 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.12699 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=0.12674 μM | SANGER | |||
| DMS-53 | Growth Inhibition Assay | IC50=0.12276 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.1246 μM | SANGER | |||
| C-4-II | Growth Inhibition Assay | IC50=0.1217 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.1212 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=0.11964 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.11831 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.11719 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=0.11466 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=0.11607 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.11195 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.11192 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.11108 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=0.11145 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=0.10899 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=0.1102 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=0.10817 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.10604 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=0.10483 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.10488 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.10431 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.10407 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.1021 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.10267 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=0.10176 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=0.09999 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.09861 μM | SANGER | |||
| MDA-MB-468 | Growth Inhibition Assay | IC50=0.09985 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.09721 μM | SANGER | |||
| IPC-298 | Growth Inhibition Assay | IC50=0.09644 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=0.09601 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=0.09541 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=0.09505 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=0.09518 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=0.09444 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.09345 μM | SANGER | |||
| EVSA-T | Growth Inhibition Assay | IC50=0.09265 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.0931 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.09218 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.09193 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=0.09215 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.09082 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=0.08991 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.08968 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=0.08855 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.08763 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=0.08498 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.08759 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.08368 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.08345 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=0.08271 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.08158 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.08165 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.08028 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=0.08156 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=0.07984 μM | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | IC50=0.07992 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000558 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=0.000125 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.00138 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=0.000842 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.00237 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.00186 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.00318 μM | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.00297 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.00266 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.00325 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=0.00449 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.00336 μM | SANGER | |||
| MES-SA | Growth Inhibition Assay | IC50=0.00452 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=0.00489 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=0.00485 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.00458 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.00518 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.00518 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.00547 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.00607 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.00591 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.00631 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.0063 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.00641 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=0.00638 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.00695 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.00663 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.00749 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=0.00703 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.00814 μM | SANGER | |||
| EW-7 | Growth Inhibition Assay | IC50=0.00754 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.00821 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00852 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=0.0084 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.00826 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.00852 μM | SANGER | |||
| SNG-M | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.00859 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.00938 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.00922 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.00945 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.01017 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00952 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.01025 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.01017 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.0103 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=0.0103 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.01059 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.01053 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.01064 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.01061 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.01071 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=0.01086 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=0.01077 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.01073 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.01102 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=0.01129 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=0.0116 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.01154 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=0.01179 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.01162 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=0.01202 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.01192 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.01261 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.01204 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.01263 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.01281 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.01272 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.01269 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.01293 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.0129 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.01293 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.01299 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.01308 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=0.01302 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.013 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=0.01336 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=0.01331 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=0.01336 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.01339 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.01366 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.01349 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.01371 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.0137 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.01384 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.01382 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.01399 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=0.01442 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.01432 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.01466 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.01499 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.01502 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.01509 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.01542 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.01514 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.01509 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=0.01586 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.01581 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.01643 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.01593 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.01646 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.01657 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.01653 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.01651 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=0.01685 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.01681 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.01702 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.01697 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.01715 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.01709 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=0.01724 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.01721 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.01735 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=0.0174 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.01736 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.01751 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.01758 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.01755 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=0.01775 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.01758 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.01788 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.01812 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.01807 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=0.01874 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.01846 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.01911 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.01884 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.01915 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.01912 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.01934 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=0.01939 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=0.0195 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.01987 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.01977 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=0.01957 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=0.02004 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.02024 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=0.02026 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.02031 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.02037 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=0.0205 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=0.02055 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=0.02059 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.02115 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.02117 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.02115 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.0212 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.02122 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.02145 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.0215 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.02171 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.02188 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.02214 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.02212 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=0.02241 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.0228 μM | SANGER | |||
| MFE-296 | Growth Inhibition Assay | IC50=0.02322 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=0.023 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.02323 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.02328 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.02329 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.02345 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.02401 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.02431 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.02433 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=0.02435 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=0.02466 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=0.02475 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.02549 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=0.02555 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.0257 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=0.02576 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.02593 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.02607 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.02613 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=0.02639 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.02646 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.02658 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.02668 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.02664 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.02677 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.02713 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=0.0271 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.02723 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.02724 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.02755 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.0276 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=0.02785 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.02796 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=0.02801 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.02806 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=0.02809 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=0.02852 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.0286 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.02887 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.02929 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.02945 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.02954 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.02955 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.02961 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.03007 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=0.03012 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=0.03014 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=0.03016 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=0.03018 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.03072 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=0.03048 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.03107 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.03125 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.03177 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.03219 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.03217 μM | SANGER | |||
| NCI-H1734 | Growth Inhibition Assay | IC50=0.0323 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.03221 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.03281 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.03289 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=0.0329 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=0.03367 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.03374 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.03383 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=0.03376 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.03388 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.03396 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=0.03389 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.03401 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.03426 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.03479 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.03538 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=0.03507 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.03608 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=0.03608 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.03613 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.03614 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=0.03617 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.03642 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=0.03663 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.03671 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.03684 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.03731 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.03747 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.03771 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=0.03789 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.03784 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=0.03812 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.03858 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.03842 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.03891 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.03872 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.03893 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.03933 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.03935 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.0395 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.03961 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.04031 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.04069 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.04114 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.0411 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.04116 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.04141 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.04157 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.04161 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.04169 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=0.04191 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.04171 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.04212 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.04227 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.04237 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.04241 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.04241 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.04272 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.04292 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.04283 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.04297 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.0433 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.04341 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.04357 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.04362 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.04407 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.04375 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.0444 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.04456 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=0.0449 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=0.04569 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.0457 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.04581 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=0.0459 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.04609 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=0.04763 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.04771 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=0.04782 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.04802 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.04803 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=0.04827 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.04826 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=0.0489 μM | SANGER | |||
| COLO-205 | Growth Inhibition Assay | IC50=0.04919 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=0.0493 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.0493 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.0495 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.0501 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=0.05052 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.05031 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=0.05176 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.05311 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.05384 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=0.05387 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=0.05395 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=0.0543 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.05452 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=0.05525 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=0.05531 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.05588 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.05683 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=0.05596 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.05683 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.05715 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=0.05733 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=0.05743 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.05734 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=0.05749 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.05802 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=0.0587 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.05872 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=0.05876 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.05879 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=0.05896 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=0.05988 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=0.06082 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.06178 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.06189 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.0623 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=0.06303 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.0627 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.06328 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.06586 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=0.06597 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=0.06604 μM | SANGER | |||
| BOKU | Growth Inhibition Assay | IC50=0.06674 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.06745 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=0.0676 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.06901 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.06918 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=0.0692 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=0.07035 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.07143 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=0.07061 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.07161 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.07172 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=0.07241 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=0.07285 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.07287 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=0.07329 μM | SANGER | |||
| Calu-1 | Growth Inhibition Assay | IC50=0.07332 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=0.07382 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.07426 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.07421 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.07456 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.07505 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=0.07526 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=0.07565 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.07535 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.07648 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.07597 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=0.07704 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.07711 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.07716 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=0.07733 μM | SANGER | |||
| DMS-153 | Growth Inhibition Assay | IC50=0.07735 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.07799 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.07868 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.07888 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.07887 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=0.07965 μM | SANGER | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro | ||||
| In vitro | NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1] | |||
|---|---|---|---|---|
| Kinase Assay | Kinase assay | |||
| NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep. | ||||
| Cell Research | Cell lines | Human gastric cancer cells NCI-N87 | ||
| Concentrations | 1 μM | |||
| Incubation Time | 3 days | |||
| Method | Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. | |||
| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western blot | p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII E-cadherin / Cleaved PARP / Bim HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK CDK4 / HMGA2 |
|
23993685 | |
| Growth inhibition assay | Cell viability |
|
26893968 | |
| In Vivo | ||
| In vivo | Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3] | |
|---|---|---|
| Animal Research | Animal Models | Female NCr athymic mice bearing WM266.4 human melanoma xenografts |
| Dosages | 50 mg/kg | |
| Administration | Administered via i.v. or i.p. | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT01772797 | Completed | Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer |
Novartis Pharmaceuticals|Novartis |
June 2013 | Phase 1 |
| NCT01752400 | Completed | Non Small Cell Lung Cancer |
Massachusetts General Hospital |
January 2013 | Phase 2 |
| NCT01613950 | Completed | Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein |
Novartis Pharmaceuticals|Novartis |
December 2012 | Phase 1 |
| NCT01484860 | Terminated | Adenocarcinoma of the Pancreas|Metastatic Disease |
University Health Network Toronto|Novartis Pharmaceuticals |
January 2012 | Phase 2 |
| NCT01402401 | Terminated | Advanced Gastric Cancer |
Novartis Pharmaceuticals|Novartis |
November 2011 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 465.54 | Formula | C26H31N3O5 |
| CAS No. | 747412-49-3 | SDF | Download Luminespib (NVP-AUY922) SDF |
| Smiles | CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C | ||
| Storage (From the date of receipt) | |||
|
In vitro |
DMSO : 93 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 31 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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