Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjEOmNKSzVyPUCuNFAxOTJ3IN88US=> NHv3dFJUSU6JRWK=
MV-4-11 NELPSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i1WmlEPTB;MD6wNFA2PThizszN NUj4cpVkW0GQR1XS
NALM-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMECwPFQzKM7:TR?= NEHjV2RUSU6JRWK=
HOS M2roNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW5TWM2OD1yLkCwNVM5KM7:TR?= NGOwcXRUSU6JRWK=
HT-144 M33wSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMECxOVUh|ryP NEDEUnlUSU6JRWK=
SW1710 NWfGbmt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1yLkCwNVg3KM7:TR?= M2TBTXNCVkeHUh?=
TE-8 NWfOeHpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXVTWM2OD1yLkCwNlM4KM7:TR?= NGHBc4FUSU6JRWK=
ES1 NVzEOmJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHrVoh5UUN3ME2wMlAxOjZ4IN88US=> NV7tcIMzW0GQR1XS
CCF-STTG1 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMECyPVch|ryP MX\TRW5ITVJ?
PSN1 NYTrNXozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMECzNVgh|ryP MkP5V2FPT0WU
CAL-51 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7oWVFKSzVyPUCuNFA{OjVizszN MoXjV2FPT0WU
MCF7 M2HaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMECzN|Uh|ryP NV;sZlBXW0GQR1XS
SK-HEP-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMECzN|Yh|ryP NYXMWXplW0GQR1XS
LCLC-103H NVXOPFRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nSZmlEPTB;MD6wNFQ{KM7:TR?= NHzFTZVUSU6JRWK=
HMV-II MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XWO2lEPTB;MD6wNFQ1QSEQvF2= NELoNlRUSU6JRWK=
MES-SA M3\HdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnDcItKSzVyPUCuNFA1PTJizszN M4TUcnNCVkeHUh?=
SK-LMS-1 NWGwU|ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\PTWM2OD1yLkCwOFU5KM7:TR?= M2mzV3NCVkeHUh?=
639-V MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fSd2lEPTB;MD6wNFQ5PSEQvF2= MlfFV2FPT0WU
SIG-M5 NXnhe5RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjFTWM2OD1yLkCwOFg6KM7:TR?= MkXyV2FPT0WU
LOUCY NYGxc2pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTVR25WUUN3ME2wMlAxPTB3IN88US=> M3\hTHNCVkeHUh?=
HSC-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TRZmlEPTB;MD6wNFUyQCEQvF2= NGXxcmRUSU6JRWK=
EW-13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC1NVgh|ryP NEntSVFUSU6JRWK=
RT-112 NGq2b3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEC1N|Uh|ryP M2P1OnNCVkeHUh?=
NKM-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOyTGVKSzVyPUCuNFA2PDdizszN NV;0dIJbW0GQR1XS
KYSE-180 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEC1PFYh|ryP NHnKfVJUSU6JRWK=
SW1783 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnLOINPUUN3ME2wMlAxPTlzIN88US=> NEnqdJpUSU6JRWK=
A431 NXvvTG1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3kdXhKSzVyPUCuNFA3ODdizszN Ml;nV2FPT0WU
SK-OV-3 M2rRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnUTWM2OD1yLkCwOlMh|ryP M{K4[XNCVkeHUh?=
RPMI-7951 NHPkeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHacWtGUUN3ME2wMlAxPjNzIN88US=> MUPTRW5ITVJ?
Capan-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i0NWlEPTB;MD6wNFY{QCEQvF2= NH:5fWFUSU6JRWK=
HSC-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\3OWlMUUN3ME2wMlAxPjRzIN88US=> MU\TRW5ITVJ?
786-0 NGDtR2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPPZ2Y6UUN3ME2wMlAxPjZ|IN88US=> MXHTRW5ITVJ?
Daoy MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEC2PVUh|ryP NHzoPFBUSU6JRWK=
KGN MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrseHBDUUN3ME2wMlAxPzB|IN88US=> MY\TRW5ITVJ?
EW-16 M3j4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnZS5o3UUN3ME2wMlAxPzR7IN88US=> NIW3b|RUSU6JRWK=
EW-7 M2XrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDyTWM2OD1yLkCwO|U1KM7:TR?= NVLvRZlNW0GQR1XS
IGROV-1 MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[1TYZKSzVyPUCuNFA5OTRizszN MVnTRW5ITVJ?
8505C MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TrVGlEPTB;MD6wNFgzOSEQvF2= MmG1V2FPT0WU
RKO M1P5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULpWnhWUUN3ME2wMlAxQDJ4IN88US=> M4j0OXNCVkeHUh?=
GDM-1 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqxTWM2OD1yLkCwPFQh|ryP MVXTRW5ITVJ?
IST-MEL1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG5RWRKSzVyPUCuNFA5PTJizszN MnzvV2FPT0WU
RPMI-6666 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEC4OVIh|ryP NEnEdGVUSU6JRWK=
SNG-M M3z5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HvZ2lEPTB;MD6wNFg2PiEQvF2= NUfHZnl3W0GQR1XS
KS-1 M1TBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xn[2lEPTB;MD6wNFg2QSEQvF2= NGTuSmlUSU6JRWK=
RXF393 M2D4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC3XplsUUN3ME2wMlAxQDZizszN MlnlV2FPT0WU
CAL-12T MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEC5NlIh|ryP M4X0RXNCVkeHUh?=
BFTC-905 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEC5N|gh|ryP M3v0VXNCVkeHUh?=
SK-MES-1 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXridG5rUUN3ME2wMlAxQTR3IN88US=> MYTTRW5ITVJ?
BB30-HNC Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nONmlEPTB;MD6wNFk2OiEQvF2= MlP1V2FPT0WU
AN3-CA NH3NVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEGwNVch|ryP NXTTd3FqW0GQR1XS
EFO-27 MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDBfoZjUUN3ME2wMlAyODF5IN88US=> NHfCNINUSU6JRWK=
G-401 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\KPHI{UUN3ME2wMlAyODJ3IN88US=> NEDYZVJUSU6JRWK=
BPH-1 MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j5NGlEPTB;MD6wNVA{KM7:TR?= MX7TRW5ITVJ?
NCI-H727 M{n1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17iWmlEPTB;MD6wNVA{KM7:TR?= MVHTRW5ITVJ?
SNU-423 M4Tsd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\hTWM2OD1yLkCxNFU{KM7:TR?= MXjTRW5ITVJ?
KYSE-270 M3Gxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEGwOVkh|ryP NE\VeFBUSU6JRWK=
AGS M2SyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ZTWM2OD1yLkCxNFYyKM7:TR?= M2XNdnNCVkeHUh?=
NCI-H2228 NVL4VIlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEGwOlQh|ryP MkfSV2FPT0WU
SW954 NWfDcnd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEGwO|Eh|ryP NU\HUXJiW0GQR1XS
769-P NWHvNW9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\4cGlEPTB;MD6wNVA4OyEQvF2= NXHSbZlOW0GQR1XS
BB49-HNC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D5S2lEPTB;MD6wNVA4PyEQvF2= NF;6R2NUSU6JRWK=
IA-LM NHTDdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEGwPFYh|ryP MYrTRW5ITVJ?
NB69 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzIPYdCUUN3ME2wMlAyOTB{IN88US=> MUPTRW5ITVJ?
C8166 NUDJU3hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL5e4lVUUN3ME2wMlAyOTJ7IN88US=> M2iyS3NCVkeHUh?=
NCI-H1299 M3nEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof3TWM2OD1yLkCxNVU1KM7:TR?= NIT3e5VUSU6JRWK=
YKG-1 NIPsdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\xemlEPTB;MD6wNVE3KM7:TR?= NH\yUFRUSU6JRWK=
PANC-03-27 NXTyWGdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3FTWM2OD1yLkCxNVYzKM7:TR?= NV7YWIhwW0GQR1XS
YT M{HqNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEGxO|kh|ryP MWrTRW5ITVJ?
CAL-85-1 NYTlOoZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nHWWlEPTB;MD6wNVE6OiEQvF2= NHLQR3BUSU6JRWK=
GT3TKB M1HVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzhSGoxUUN3ME2wMlAyOjB{IN88US=> M17heXNCVkeHUh?=
BB65-RCC NELT[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrBPIh2UUN3ME2wMlAyOjB2IN88US=> NXjQdno5W0GQR1XS
ES6 NVj4XFVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv5TWM2OD1yLkCxNlYyKM7:TR?= MYLTRW5ITVJ?
MHH-ES-1 M2Hzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hme2lEPTB;MD6wNVI3OyEQvF2= NFLjXlVUSU6JRWK=
QIMR-WIL MnzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEGyOlkh|ryP MmfoV2FPT0WU
SNU-C2B M1vsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPOTWM2OD1yLkCxNlczKM7:TR?= M3fkcnNCVkeHUh?=
OCI-AML2 M2PsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOxdGNKSzVyPUCuNFEzQDFizszN MVfTRW5ITVJ?
DU-145 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjVPXFKSzVyPUCuNFEzQSEQvF2= NIHFXlJUSU6JRWK=
SW982 NYX2NlUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPhSYtoUUN3ME2wMlAyOjl|IN88US=> MXzTRW5ITVJ?
MFH-ino NELiXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWwVWRKSzVyPUCuNFEzQTNizszN MmfVV2FPT0WU
A427 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7nW3pKSzVyPUCuNFEzQTlizszN NHqwZo5USU6JRWK=
LCLC-97TM1 NFLIeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj6WXdrUUN3ME2wMlAyOyEQvF2= MV;TRW5ITVJ?
AM-38 NFGxe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPCOYZnUUN3ME2wMlAyOzB{IN88US=> MknKV2FPT0WU
K5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEGzNFgh|ryP MoLQV2FPT0WU
T84 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW2WYhKSzVyPUCuNFE{OzFizszN NGPLWmRUSU6JRWK=
TE-15 MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj6TnNKSzVyPUCuNFE{OzZizszN MVTTRW5ITVJ?
NCI-H460 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u4WWlEPTB;MD6wNVM{PiEQvF2= MnPoV2FPT0WU
NTERA-S-cl-D1 NFrpRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XBXWlEPTB;MD6wNVM{QSEQvF2= NHHw[ZpUSU6JRWK=
KYSE-450 NIHVRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEGzOFkh|ryP M33VWnNCVkeHUh?=
H4 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu0SYhKSzVyPUCuNFE{PjZizszN NEnLVnhUSU6JRWK=
LC-2-ad Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzybW45UUN3ME2wMlAyOzdizszN MVnTRW5ITVJ?
GAMG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrWTWM2OD1yLkCxN|cyKM7:TR?= MkTsV2FPT0WU
TK10 M{TET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Lu[2lEPTB;MD6wNVM5OiEQvF2= MYrTRW5ITVJ?
NCI-H2122 NVS4e4hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LSSmlEPTB;MD6wNVM5PCEQvF2= NEWxU4dUSU6JRWK=
KM12 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\vTWM2OD1yLkCxN|k6KM7:TR?= MYfTRW5ITVJ?
CAL-39 NXPwNmhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEG0NkDPxE1? MlO4V2FPT0WU
RPMI-2650 NYC0N|RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEG0N|Ih|ryP MkLiV2FPT0WU
KYSE-510 M3q0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzPTWM2OD1yLkCxOFQzKM7:TR?= MojiV2FPT0WU
KALS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLU[mJxUUN3ME2wMlAyPDZ4IN88US=> NWDSUXFuW0GQR1XS
NCI-H1648 M1TKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEG0PVkh|ryP NFriUphUSU6JRWK=
ES4 NICxNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jMUGlEPTB;MD6wNVUxOiEQvF2= M336PXNCVkeHUh?=
C-33-A MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfp[WVKSzVyPUCuNFE2ODlizszN NHHjVWxUSU6JRWK=
MIA-PaCa-2 NUPKelhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:3fWlEPTB;MD6wNVUxQSEQvF2= MWPTRW5ITVJ?
Becker M124U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j5TGlEPTB;MD6wNVUyPCEQvF2= MnzYV2FPT0WU
HOP-62 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;lTWM2OD1yLkCxOVQzKM7:TR?= MXzTRW5ITVJ?
TE-1 NH3VUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEG1PFEh|ryP NY\tZll1W0GQR1XS
KYSE-410 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEG1PFYh|ryP NEHFdoJUSU6JRWK=
NOS-1 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrxU|VLUUN3ME2wMlAyPTl|IN88US=> MVrTRW5ITVJ?
MEL-HO NVnmVFh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vR25KSzVyPUCuNFE3PDNizszN MnvkV2FPT0WU
NCI-H1650 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTYTWM2OD1yLkCxOlQ3KM7:TR?= NV7COZQxW0GQR1XS
VMRC-RCZ NV:wZVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXleIQ4UUN3ME2wMlAyPjVzIN88US=> M{PySnNCVkeHUh?=
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RS4-11 NEPhTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEOzPFMh|ryP MkKxV2FPT0WU
JiyoyeP-2003 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEOzPFgh|ryP MoHUV2FPT0WU
BL-70 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nPfWlEPTB;MD6wN|M5QSEQvF2= MV7TRW5ITVJ?
OS-RC-2 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEOzPVYh|ryP NVTiVIpkW0GQR1XS
SF268 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jlSGlEPTB;MD6wN|QxOSEQvF2= NFywU3ZUSU6JRWK=
BV-173 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL1dmJvUUN3ME2wMlA{PDJ4IN88US=> NXXLS2RIW0GQR1XS
DMS-273 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfP[2JKSzVyPUCuNFM1PzlizszN NVvZW4ZHW0GQR1XS
22RV1 NYm4fGl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXWTWM2OD1yLkCzOVA4KM7:TR?= MYfTRW5ITVJ?
ES8 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mxeGlEPTB;MD6wN|U{QCEQvF2= MoDHV2FPT0WU
KYSE-150 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfRTWM2OD1yLkCzOlA5KM7:TR?= M{XtNXNCVkeHUh?=
HCC1569 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEO2NFgh|ryP NV\3OWR7W0GQR1XS
NB5 M2n5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn4[m5XUUN3ME2wMlA{PjF|IN88US=> MkfQV2FPT0WU
G-402 MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfKXZFKSzVyPUCuNFM3OTRizszN NGCwW|BUSU6JRWK=
NCI-H1693 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\aTWM2OD1yLkCzOlE4KM7:TR?= NVjSdHNJW0GQR1XS
LB2241-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm5TWM2OD1yLkCzOlQzKM7:TR?= MnfvV2FPT0WU
KP-4 NIXL[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLXTW1WUUN3ME2wMlA{PjZ|IN88US=> Mnq5V2FPT0WU
ML-2 NFjZ[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHIfXlKSzVyPUCuNFM3PzFizszN Mny0V2FPT0WU
KU812 NHftRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjsTWM2OD1yLkCzOlg1KM7:TR?= NIrHZllUSU6JRWK=
LS-411N NHjySXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;xZXBoUUN3ME2wMlA{PzNzIN88US=> MYTTRW5ITVJ?
OAW-42 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HXbGlEPTB;MD6wN|c1PyEQvF2= MoK2V2FPT0WU
HCC38 M{nlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrp[2VKSzVyPUCuNFM4PzFizszN MnvtV2FPT0WU
Ca-Ski MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTqO21EUUN3ME2wMlA{Pzh2IN88US=> M1f1dHNCVkeHUh?=
Calu-3 NImwdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvHPJVXUUN3ME2wMlA{Pzh7IN88US=> NG[wTIhUSU6JRWK=
KYSE-70 MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEO4NVIh|ryP Mnr1V2FPT0WU
D-392MG NHH3OnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDxWIpKSzVyPUCuNFM5PDJizszN MnrRV2FPT0WU
OVCAR-4 Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\JOZFKSzVyPUCuNFM5PThizszN M3TsW3NCVkeHUh?=
Detroit562 M2\UW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[3R2lEPTB;MD6wN|g4OiEQvF2= MnL0V2FPT0WU
HEL NGC3RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LVV2lEPTB;MD6wN|g6OSEQvF2= MVrTRW5ITVJ?
MONO-MAC-6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rkVWlEPTB;MD6wN|g6OyEQvF2= NInOW3ZUSU6JRWK=
LoVo NVX2d|U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7RephKSzVyPUCuNFM6OzNizszN NX7MXJozW0GQR1XS
U-2-OS NFzTXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS3[otIUUN3ME2wMlA{QTN3IN88US=> MkfKV2FPT0WU
A172 M3z2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[4NmlEPTB;MD6wN|k2KM7:TR?= MkjzV2FPT0WU
OCUB-M M{K4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv3TWM2OD1yLkCzPVYyKM7:TR?= MlXLV2FPT0WU
SW48 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvSGlEPTB;MD6wOFA{OSEQvF2= M1vFOXNCVkeHUh?=
HC-1 M2LTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfoTWM2OD1yLkC0NFY6KM7:TR?= MV;TRW5ITVJ?
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\EN5hnUUN3ME2wMlA1OTFizszN NVvsUoFYW0GQR1XS
HDLM-2 M3TOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jdW0yUUN3ME2wMlA1OTF2IN88US=> NWnOOnAxW0GQR1XS
CTV-1 NWnjNms2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL5VlROUUN3ME2wMlA1OTF4IN88US=> MkHuV2FPT0WU
SH-4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMESxOFEh|ryP MWXTRW5ITVJ?
SW756 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T5TmlEPTB;MD6wOFE2PyEQvF2= NYDWemZ{W0GQR1XS
GCT MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzUNHZKSzVyPUCuNFQyPjFizszN M4\YcnNCVkeHUh?=
CHL-1 NX7jWWJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMESxOlkh|ryP MWPTRW5ITVJ?
LAMA-84 NIXvcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S3V2lEPTB;MD6wOFE4OSEQvF2= MoTaV2FPT0WU
LS-1034 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHWNYJKSzVyPUCuNFQyQTFizszN MWrTRW5ITVJ?
NCI-H358 NXjodYF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr4bnRKSzVyPUCuNFQzOTJizszN NIXZWHNUSU6JRWK=
NB13 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7lOFFHUUN3ME2wMlA1OjJ5IN88US=> M3L0bXNCVkeHUh?=
TE-9 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHsZoxKSzVyPUCuNFQzOzdizszN NYPIUJdkW0GQR1XS
OE33 MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK0TWM2OD1yLkC0NlQyKM7:TR?= NGfp[pVUSU6JRWK=
CAL-120 NHeybZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\WTWM2OD1yLkC0NlQyKM7:TR?= NELTS2FUSU6JRWK=
DJM-1 NUnuOpJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHKTWM2OD1yLkC0NlczKM7:TR?= M4TKUnNCVkeHUh?=
SK-MEL-24 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTwTWM2OD1yLkC0Nlg{KM7:TR?= NUHtdmRyW0GQR1XS
VA-ES-BJ M2\mVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETsXIVKSzVyPUCuNFQzQTJizszN MUTTRW5ITVJ?
MMAC-SF M4O3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;3TWM2OD1yLkC0Nlk4KM7:TR?= NETpRlJUSU6JRWK=
MZ7-mel MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlixTWM2OD1yLkC0N|Mh|ryP MnLDV2FPT0WU
BxPC-3 NXvVTZNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMESzOFEh|ryP MVfTRW5ITVJ?
HT-29 M{D0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TsXWlEPTB;MD6wOFM2PyEQvF2= Mn;BV2FPT0WU
SK-MEL-30 M3;hZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDaeppVUUN3ME2wMlA1OzZ{IN88US=> MXrTRW5ITVJ?
CAL-33 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMESzO|Uh|ryP NGTlTmlUSU6JRWK=
COLO-680N NY[wNJpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOTGlEPTB;MD6wOFQxPyEQvF2= M{TTOnNCVkeHUh?=
NH-12 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf6ZY9sUUN3ME2wMlA1PDRizszN NEDUWJVUSU6JRWK=
HCC1937 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMES0OVYh|ryP Mo\XV2FPT0WU
IMR-5 M1W1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fGXGlEPTB;MD6wOFQ6KM7:TR?= MlHkV2FPT0WU
MC-CAR MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjp[Y1UUUN3ME2wMlA1PTZ7IN88US=> NVLUdnpWW0GQR1XS
NCI-H747 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LKTGlEPTB;MD6wOFU4KM7:TR?= NX\3e4xGW0GQR1XS
NCI-H1792 NVrBdWROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\GXJN2UUN3ME2wMlA1PThzIN88US=> NX\BNYdQW0GQR1XS
SW13 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPNUZJYUUN3ME2wMlA1PTlizszN MkjhV2FPT0WU
MLMA MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMES2NFkh|ryP NFPuZ2dUSU6JRWK=
U251 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnOWGRDUUN3ME2wMlA1PzZ|IN88US=> NWfJUHpVW0GQR1XS
U031 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nwNmlEPTB;MD6wOFc4OSEQvF2= MVPTRW5ITVJ?
ME-180 NXLq[3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMES3PFIh|ryP NWnmUIV[W0GQR1XS
SK-MEL-3 NY\sVnJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHMZoVKSzVyPUCuNFQ5ODJizszN MojXV2FPT0WU
MOLT-4 NYjIZYlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLBTWM2OD1yLkC0PFA{KM7:TR?= M1TYcHNCVkeHUh?=
PF-382 M16y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDaVmJKSzVyPUCuNFQ5OjZizszN NVT4WlJrW0GQR1XS
NUGC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMES4Nlch|ryP Mne5V2FPT0WU
NCI-H1417 M1i0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMES4PUDPxE1? MYrTRW5ITVJ?
COLO-205 M{W0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m1[WlEPTB;MD6wOFkyQSEQvF2= MoPTV2FPT0WU
TE-441-T NGXWd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTLTWM2OD1yLkC0PVMh|ryP M{\ZdHNCVkeHUh?=
MKN1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonkTWM2OD1yLkC0PVMh|ryP MYPTRW5ITVJ?
UM-UC-3 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMES5OUDPxE1? M{\lOXNCVkeHUh?=
SF126 M4niXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXLc5BKSzVyPUCuNFUxOSEQvF2= NHnwOHpUSU6JRWK=
LB1047-RCC Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1THfGlEPTB;MD6wOVA{OSEQvF2= NV7YZZBjW0GQR1XS
A253 M{jWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe3PG1SUUN3ME2wMlA2ODV{IN88US=> M4riN3NCVkeHUh?=
NCI-H1963 NWf1VYRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HRbGlEPTB;MD6wOVE4PiEQvF2= NFT4Z45USU6JRWK=
VM-CUB-1 NXjrdYt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HNbWlEPTB;MD6wOVMyOSEQvF2= M3fUVHNCVkeHUh?=
T-24 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO4ZZNyUUN3ME2wMlA2Ozh2IN88US=> MUTTRW5ITVJ?
K-562 NGn4RXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfjRWdZUUN3ME2wMlA2Ozh5IN88US=> NGTjWnBUSU6JRWK=
ARH-77 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCwVZlmUUN3ME2wMlA2Ozl3IN88US=> NHi1UmNUSU6JRWK=
CA46 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfXTWM2OD1yLkC1OFMh|ryP Ml3vV2FPT0WU
HCC70 NFLoR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEW0OVIh|ryP M3zp[3NCVkeHUh?=
ST486 M1PpV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTTSXR1UUN3ME2wMlA2PTJ3IN88US=> MV;TRW5ITVJ?
COLO-741 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe3fW83UUN3ME2wMlA2PTNzIN88US=> NWHLdFd7W0GQR1XS
SK-PN-DW NInDRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TlSWlEPTB;MD6wOVU5QCEQvF2= NGrtVFJUSU6JRWK=
BL-41 M2DJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LOSWlEPTB;MD6wOVU6PiEQvF2= NILoXHdUSU6JRWK=
D-263MG NEjYeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnGeY1RUUN3ME2wMlA2Pjh|IN88US=> MX\TRW5ITVJ?
KE-37 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHFdGpKSzVyPUCuNFU3QDNizszN NUjofmJZW0GQR1XS
LU-134-A M1v5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEW3NVUh|ryP NXHpOWNVW0GQR1XS
HCC2157 NHzab2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEW3N|Mh|ryP NIDQcoVUSU6JRWK=
GAK M37DbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvQWnlZUUN3ME2wMlA2PzN2IN88US=> M2\HTXNCVkeHUh?=
IST-SL2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEW3OFMh|ryP NFzzO4ZUSU6JRWK=
KMOE-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;zfWlEPTB;MD6wOVc1QSEQvF2= Mke1V2FPT0WU
SW1573 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEW4NFIh|ryP NILScYtUSU6JRWK=
SCC-9 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TJR2lEPTB;MD6wOVg4KM7:TR?= M3rEVHNCVkeHUh?=
MDA-MB-361 NH\IT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:w[|NKSzVyPUCuNFU5PzJizszN NInSW5hUSU6JRWK=
BHT-101 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjUN2xKSzVyPUCuNFU5PzZizszN NVrxeHRuW0GQR1XS
NCI-H1770 NH3XOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HJV2lEPTB;MD6wOVg4QSEQvF2= NVjRcXBZW0GQR1XS
UACC-893 M3PnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrsTWM2OD1yLkC1PFk3KM7:TR?= M1[5VXNCVkeHUh?=
NCI-H226 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEW5PFgh|ryP M1fLU3NCVkeHUh?=
HLE M4XCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLa[3d2UUN3ME2wMlA3ODh{IN88US=> MV;TRW5ITVJ?
NCI-H1703 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TvZ2lEPTB;MD6wOlE4QCEQvF2= MW\TRW5ITVJ?
KURAMOCHI MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n4fmlEPTB;MD6wOlE5QSEQvF2= M4iyR3NCVkeHUh?=
RH-1 M{LnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwME[yN{DPxE1? MX7TRW5ITVJ?
DSH1 NFvsbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu5fodKSzVyPUCuNFYzPyEQvF2= MWPTRW5ITVJ?
CAMA-1 M1izfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOwVVF[UUN3ME2wMlA3OzB|IN88US=> NGPvOohUSU6JRWK=
NCI-H1437 NXjPc2tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\WOZB2UUN3ME2wMlA3OzJ6IN88US=> NGfScIpUSU6JRWK=
HuP-T4 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KzTmlEPTB;MD6wOlU5PiEQvF2= NFrweJJUSU6JRWK=
HCT-15 M4DxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36xcWlEPTB;MD6wOlU6PyEQvF2= NX3MS4FQW0GQR1XS
NCCIT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPHTWM2OD1yLkC2OlA1KM7:TR?= MlHpV2FPT0WU
BOKU NEXBe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGriZ2xKSzVyPUCuNFY3PzRizszN MlzsV2FPT0WU
FADU MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nvUmlEPTB;MD6wOlc1PSEQvF2= MorNV2FPT0WU
SUP-T1 NIfuUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTjTWM2OD1yLkC2O|Yh|ryP NH21[|VUSU6JRWK=
L-363 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwME[5NFEh|ryP MVjTRW5ITVJ?
KNS-81-FD MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzMTWM2OD1yLkC2PVE5KM7:TR?= MV3TRW5ITVJ?
SU-DHL-1 NGTMTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX21U|BsUUN3ME2wMlA3QTJizszN MlH5V2FPT0WU
HuH-7 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nTOWlEPTB;MD6wO|A{PSEQvF2= MXzTRW5ITVJ?
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NCI-H748 NF\kVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjHTpRRUUN3ME2xMlM2PzN6IN88US=> M4rQSXNCVkeHUh?=
HCC1187 NGGxc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSyR4tKSzVyPUGuOVU2OjJizszN NVTQeVJOW0GQR1XS
EoL-1-cell NUPXTpZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi4ZnNKSzVyPUGuOVg5QDlizszN NYjkPFM6W0GQR1XS
HuO-3N1 M{W4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HGXWlEPTB;MT64N|QyOiEQvF2= NWmybGdtW0GQR1XS
NCI-H1793 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLhTWM2OD1zLki3OVk{KM7:TR?= MUDTRW5ITVJ?
Caov-3 M4nkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXQXJhKSzVyPUKuNFA3OjVizszN NWjpeoRbW0GQR1XS
JAR NWq5ZppCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\0dG1KSzVyPUKuNFc6OiEQvF2= MVLTRW5ITVJ?
SK-MEL-28 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnFV4pKSzVyPUKuNVgxQThizszN NET0SXpUSU6JRWK=
EM-2 NHX6NJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OwT2lEPTB;Mj6yNFI6OyEQvF2= MUXTRW5ITVJ?
Mewo MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf5[446UUN3ME2yMlIzOjZ3IN88US=> NHrZ[2VUSU6JRWK=
NCI-H720 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOzOpJGUUN3ME2yMlI3PTh3IN88US=> M2X3SnNCVkeHUh?=
CAL-54 NWXETWJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjQSVZKSzVyPUKuNlY4QTVizszN MXPTRW5ITVJ?
MC116 NYjFTlhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwM{[zPVch|ryP MXvTRW5ITVJ?
DG-75 M2PuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonWTWM2OD1{LkS4OVc3KM7:TR?= NEfNV21USU6JRWK=
HCC1143 M4Pmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm2Vm5vUUN3ME2yMlUxPjV6IN88US=> MVLTRW5ITVJ?
FTC-133 MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwNUO2PFkh|ryP M1\HWnNCVkeHUh?=
AsPC-1 NGjROJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJwNUO5Nlkh|ryP NVTVZ2NmW0GQR1XS
NCI-H889 M1vWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;F[WlEPTB;Mj61OlcxPiEQvF2= Mle4V2FPT0WU
HT55 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnvdmxiUUN3ME2yMlYzODF7IN88US=> M4m3TXNCVkeHUh?=
UMC-11 NV2xZoxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJwN{i3NVUh|ryP NYXNRZhqW0GQR1XS
P12-ICHIKAWA MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPyTHBJUUN3ME2yMlgzODR4IN88US=> Mn3TV2FPT0WU
HCC1395 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwOUi2NFIh|ryP NYW4WW95W0GQR1XS
D-283MED NY[zVIpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITpbG1KSzVyPUOuNVg6OzdizszN MXfTRW5ITVJ?
COLO-800 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHhZnFKSzVyPUOuN|M5QTdizszN MVXTRW5ITVJ?
MFM-223 NInhW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6yTWM2OD1|LkO2NFk4KM7:TR?= NUTsZYdQW0GQR1XS
TE-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXrdoo4UUN3ME20MlU3OTR5IN88US=> MnX4V2FPT0WU
NCI-H209 NGS0emZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLPUZNsUUN3ME20Mlc5PTd{IN88US=> NWTETFRpW0GQR1XS
SiHa MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XEN2lEPTB;ND65OVIxOyEQvF2= MVjTRW5ITVJ?
NCI-H1395 NH7JcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MliyTWM2OD13LkGwOlM{KM7:TR?= MWLTRW5ITVJ?
A498 NUK1Nmk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rUN2lEPTB;NT6yNVI2OSEQvF2= M2SyUnNCVkeHUh?=
ES5 NXvoTFhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK1d2JKSzVyPUWuOlEyPzhizszN NEDG[odUSU6JRWK=
MDA-MB-157 NHLEdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDITWM2OD13Lk[2OFQ{KM7:TR?= MlruV2FPT0WU
NCI-H1623 NGW0ZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD13LkizOVU3KM7:TR?= MVXTRW5ITVJ?
RPMI-8866 NVLOR5JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfDTWM2OD13Lki0O|kzKM7:TR?= MYnTRW5ITVJ?
LC-1F M4nhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X6SWlEPTB;Nj6wPVI6OSEQvF2= NIHDbmFUSU6JRWK=
TCCSUP MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnxfHpKSzVyPU[uOlA{PDlizszN NVLqUohOW0GQR1XS
TT NIi0NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPWTWM2OD16LkOzNFA6KM7:TR?= NXrle2VoW0GQR1XS
NCI-H1838 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRThwNUG3N|Eh|ryP M{npOXNCVkeHUh?=
NCI-H322M Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\2foc{UUN3ME25MlE3OjhzIN88US=> NH;xbpJUSU6JRWK=
NCI-H187 MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW3S5V5UUN3ME25MlUyQDN3IN88US=> NWm0TYFFW0GQR1XS
SBC-1 NYjkRnF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTlwOUO2OVYh|ryP M4fTTHNCVkeHUh?=
SCC-3 NV3YUHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFyLkW2O|kh|ryP NEDVdXVUSU6JRWK=
SW948 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LPWmlEPTB;MUCuO|UyOSEQvF2= MX3TRW5ITVJ?
CPC-N NUDhb4NCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Sxc2lEPTB;MUGuNFA4KM7:TR?= M3nlcnNCVkeHUh?=
TGBC24TKB MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK2SoFKSzVyPUGzMlUzQSEQvF2= NELaNlRUSU6JRWK=
NCI-H2452 Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m2d2lEPTB;MUSuO|Mh|ryP NXjIPZd{W0GQR1XS
Hs-578-T MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF6LkW3OVkh|ryP NIL3NZBUSU6JRWK=
DV-90 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHlTWM2OD1zOD65PVQ2KM7:TR?= NEnFTI9USU6JRWK=
NCI-H1563 NWP2XmZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zqT2lEPTB;MUmuO|g5QCEQvF2= M2S1b3NCVkeHUh?=
SW780 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVKzWWN{UUN3ME2yNU4yOzF6IN88US=> NY\lZWd5W0GQR1XS
NCI-H345 M{XF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrITWM2OD1{MT64O|c6KM7:TR?= NHnHcI1USU6JRWK=
LB771-HNC NYHRcGtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7wTWM2OD1{Mj60PFE{KM7:TR?= MY\TRW5ITVJ?
RT4 M3HPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXsTWM2OD1{Mz6zNlgzKM7:TR?= NWLUcFRVW0GQR1XS
NCI-H82 NX3CXZNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHMTWM2OD1{Mz61OVI3KM7:TR?= MVLTRW5ITVJ?
NCI-H524 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\RPGlEPTB;MkSuN|gyOiEQvF2= NVfwR4VnW0GQR1XS
SNU-C1 NInWd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLBTWM2OD1{ND65NVA2KM7:TR?= NGO1dnBUSU6JRWK=
NCI-SNU-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[0NWlEPTB;NEiuN|E1OiEQvF2= NYDOVFdJW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID