Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 44 Publications

Cancer Cell, 2019, 35(5):752-766

PubMed: 31085176 ( click the link to review the publication )

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062 ( click the link to review the publication )

J Neurosci, 2019, 39(17):3332-3344

PubMed: 30696728 ( click the link to review the publication )

BMC Cancer, 2019, 19(1):102

PubMed: 30678647 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(24):6548-6555

PubMed: 30154228 ( click the link to review the publication )

Mol Syst Biol, 2018, 14(3):e7858

PubMed: 29507054 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(3):1792-1804

PubMed: 29363851 ( click the link to review the publication )

Cancer Lett, 2017, 411:19-26

PubMed: 28987383 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2017, 80(4):673-684

PubMed: 28779264 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 487(2):313-319

PubMed: 28412368 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:2219-2226

PubMed: 28458565 ( click the link to review the publication )

Sci Rep, 2017, 7(1):201

PubMed: 28298630 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )

J Biol Chem, 2016, 291(19):10332-46

PubMed: 26957545 ( click the link to review the publication )

Horm Cancer, 2016, 7(2):114-26

PubMed: 26858237 ( click the link to review the publication )

PeerJ, 2016, 4:e1683

PubMed: 26893968 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Immun Inflamm Dis, 2016, 4(4):463-473

PubMed: 27980780 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2015, 309(12):L1410-9

PubMed: 26498249 ( click the link to review the publication )

Int J Biol Sci, 2015, 11(8):923-34

PubMed: 26157347 ( click the link to review the publication )

Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )
PLoS One, 2015, 10(3):e0119832

PubMed: 25780909 ( click the link to review the publication )

Oncol Lett, 2015, 10(2):941-945

PubMed: 26622600 ( click the link to review the publication )

Oncotarget, 2015, 6(31):31792-804

PubMed: 26397139 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778 ( click the link to review the publication )

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

PLoS One, 2014, 9(12):e114506

PubMed: 25503774 ( click the link to review the publication )

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175 ( click the link to review the publication )

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685 ( click the link to review the publication )

J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

J Proteome Res, 2013, 12(8):3697-706

PubMed: 23763277 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418 ( click the link to review the publication )

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346 ( click the link to review the publication )

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466 ( click the link to review the publication )

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed: ( click the link to review the publication )

Mol Cancer, 2011, 10:125

PubMed: 21962244 ( click the link to review the publication )

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkK1TWM2OD1yLkCwNFEzPSEQvF2=	NE\idHlUSU6JRWK=
MV-4-11	M{\BVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nScGlEPTB;MD6wNFA2PThizszN	NWKzVpRvW0GQR1XS
NALM-6	NVvqXlhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvxfG86UUN3ME2wMlAxODh2MjFOwG0>	MVXTRW5ITVJ?
HOS	M1zWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGTOWGhKSzVyPUCuNFAyOzhizszN	MnHtV2FPT0WU
HT-144	NYrVNIQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3nSUmlEPTB;MD6wNFE2PSEQvF2=	M4roNHNCVkeHUh?=
SW1710	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fmPWlEPTB;MD6wNFE5PiEQvF2=	NFzNSZJUSU6JRWK=
TE-8	NY\oSFJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXXJR\|UxRTBwMECyN\|ch\|ryP	M2HYenNCVkeHUh?=
ES1	M1jVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFm0fGJKSzVyPUCuNFAzPjZizszN	NEHlU\|NUSU6JRWK=
CCF-STTG1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4n3W2lEPTB;MD6wNFI6PyEQvF2=	NULoTohHW0GQR1XS
PSN1	NXm4O5RKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEXJRYlKSzVyPUCuNFA{OThizszN	MlnqV2FPT0WU
CAL-51	M2rvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHH6VIZKSzVyPUCuNFA{OjVizszN	MlSyV2FPT0WU
MCF7	M{\FRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;oPWdKSzVyPUCuNFA{OzVizszN	NFW3em5USU6JRWK=
SK-HEP-1	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMECzN\|Yh\|ryP	M1rmcnNCVkeHUh?=
LCLC-103H	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPZ[ppKSzVyPUCuNFA1OyEQvF2=	NGi3SZRUSU6JRWK=
HMV-II	M2\qR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;hZnZKSzVyPUCuNFA1PDlizszN	MmPEV2FPT0WU
MES-SA	M2W3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4e4dGlEPTB;MD6wNFQ2OiEQvF2=	MVHTRW5ITVJ?
SK-LMS-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWDid5pzUUN3ME2wMlAxPDV6IN88US=>	NVfj[ItxW0GQR1XS
639-V	NVm1O5pnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2DoTWlEPTB;MD6wNFQ5PSEQvF2=	MXHTRW5ITVJ?
SIG-M5	M4CwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVuwXFZMUUN3ME2wMlAxPDh7IN88US=>	MWTTRW5ITVJ?
LOUCY	M3n5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUXOR\|V[UUN3ME2wMlAxPTB3IN88US=>	MYDTRW5ITVJ?
HSC-2	NUDpO5JWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmjuTWM2OD1yLkCwOVE5KM7:TR?=	NILzfYpUSU6JRWK=
EW-13	NEPGfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3Twd2lEPTB;MD6wNFUyQCEQvF2=	MV;TRW5ITVJ?
RT-112	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjZRY8{UUN3ME2wMlAxPTN3IN88US=>	MmLXV2FPT0WU
NKM-1	MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGDMendKSzVyPUCuNFA2PDdizszN	MXTTRW5ITVJ?
KYSE-180	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml3NTWM2OD1yLkCwOVg3KM7:TR?=	MkjwV2FPT0WU
SW1783	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTBwMEC1PVEh\|ryP	MXPTRW5ITVJ?
A431	M1viTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUfJR\|UxRTBwMEC2NFch\|ryP	MlLxV2FPT0WU
SK-OV-3	M1nwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDkW4k2UUN3ME2wMlAxPjNizszN	MUPTRW5ITVJ?
RPMI-7951	NGS5e4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTMTWM2OD1yLkCwOlMyKM7:TR?=	MnvVV2FPT0WU
Capan-2	NIXv[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFrJNllKSzVyPUCuNFA3OzhizszN	NF3PXJhUSU6JRWK=
HSC-3	MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\1TWM2OD1yLkCwOlQyKM7:TR?=	M{nyXHNCVkeHUh?=
786-0	NX3PTZk5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{S3ZmlEPTB;MD6wNFY3OyEQvF2=	M{mwS3NCVkeHUh?=
Daoy	NVqzToVFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3KT\|NLUUN3ME2wMlAxPjl3IN88US=>	M1nOTHNCVkeHUh?=
KGN	NITVRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXKzfYhSUUN3ME2wMlAxPzB\|IN88US=>	MWfTRW5ITVJ?
EW-16	MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLmd\|hKSzVyPUCuNFA4PDlizszN	MYXTRW5ITVJ?
EW-7	NWnDd\|FoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfYPXBKSzVyPUCuNFA4PTRizszN	MV;TRW5ITVJ?
IGROV-1	NFjCeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPGU5kyUUN3ME2wMlAxQDF2IN88US=>	NV35O3llW0GQR1XS
8505C	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzHbI5{UUN3ME2wMlAxQDJzIN88US=>	M2H0XXNCVkeHUh?=
RKO	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrJ[HJKSzVyPUCuNFA5OjZizszN	NIrCdVVUSU6JRWK=
GDM-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVrJR\|UxRTBwMEC4OEDPxE1?	NUnqfXo4W0GQR1XS
IST-MEL1	MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXWTWM2OD1yLkCwPFUzKM7:TR?=	M2DOUHNCVkeHUh?=
RPMI-6666	M17uVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLW[5hDUUN3ME2wMlAxQDV{IN88US=>	MlfiV2FPT0WU
SNG-M	NIKzVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2[5ZWlEPTB;MD6wNFg2PiEQvF2=	M3T0N3NCVkeHUh?=
KS-1	M3WyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoHNTWM2OD1yLkCwPFU6KM7:TR?=	MoL1V2FPT0WU
RXF393	MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXTJ[mJvUUN3ME2wMlAxQDZizszN	MX7TRW5ITVJ?
CAL-12T	NFLSWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4jOdWlEPTB;MD6wNFkzOiEQvF2=	M2XUZnNCVkeHUh?=
BFTC-905	NY\xUXF6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIT0enBKSzVyPUCuNFA6OzhizszN	M1;MWnNCVkeHUh?=
SK-MES-1	MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml;LTWM2OD1yLkCwPVQ2KM7:TR?=	MVrTRW5ITVJ?
BB30-HNC	NETxVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LmVmlEPTB;MD6wNFk2OiEQvF2=	NFi2OXdUSU6JRWK=
AN3-CA	NF\wW\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTBwMEGwNVch\|ryP	MlG1V2FPT0WU
EFO-27	M4C1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE\0d5ZKSzVyPUCuNFExOTdizszN	M2rKbnNCVkeHUh?=
G-401	NFXFUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M17w[GlEPTB;MD6wNVAzPSEQvF2=	Mkm4V2FPT0WU
BPH-1	MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TrRmlEPTB;MD6wNVA{KM7:TR?=	MWTTRW5ITVJ?
NCI-H727	NFTMe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGrNbodKSzVyPUCuNFExOyEQvF2=	NITTTYtUSU6JRWK=
SNU-423	MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1X6S2lEPTB;MD6wNVA2OyEQvF2=	NEPteJlUSU6JRWK=
KYSE-270	NWLiOGZVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fUUGlEPTB;MD6wNVA2QSEQvF2=	NGjC[o9USU6JRWK=
AGS	MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWTKWmV3UUN3ME2wMlAyODZzIN88US=>	M4GxeXNCVkeHUh?=
NCI-H2228	M3vXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTBwMEGwOlQh\|ryP	NUnue2xQW0GQR1XS
SW954	NYC3R2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1;3VmlEPTB;MD6wNVA4OSEQvF2=	MlrmV2FPT0WU
769-P	NVrP[WpqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoryTWM2OD1yLkCxNFc{KM7:TR?=	MV\TRW5ITVJ?
BB49-HNC	MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFrGZXlKSzVyPUCuNFExPzdizszN	M3fhXXNCVkeHUh?=
IA-LM	Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTBwMEGwPFYh\|ryP	MoXRV2FPT0WU
NB69	M123fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFzGPIxKSzVyPUCuNFEyODJizszN	NIH2Z\|JUSU6JRWK=
C8166	NXf1SJJQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGnmZotKSzVyPUCuNFEyOjlizszN	NGK3R3NUSU6JRWK=
NCI-H1299	NXK0Xoh1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoHDTWM2OD1yLkCxNVU1KM7:TR?=	M{fpN3NCVkeHUh?=
YKG-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYLJR\|UxRTBwMEGxOkDPxE1?	NHH2UZRUSU6JRWK=
PANC-03-27	NFTjPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\mTWM2OD1yLkCxNVYzKM7:TR?=	NEPqdYtUSU6JRWK=
YT	NUXBRnV[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zSTmlEPTB;MD6wNVE4QSEQvF2=	MX\TRW5ITVJ?
CAL-85-1	M37qcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTBwMEGxPVIh\|ryP	NHHYfJBUSU6JRWK=
GT3TKB	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvhTIRkUUN3ME2wMlAyOjB{IN88US=>	Mn;oV2FPT0WU
BB65-RCC	NILQO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfITFl2UUN3ME2wMlAyOjB2IN88US=>	M4nqO3NCVkeHUh?=
ES6	NWfSNZZxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHwe25KSzVyPUCuNFEzPjFizszN	MWrTRW5ITVJ?
MHH-ES-1	M2PqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTBwMEGyOlMh\|ryP	MnOxV2FPT0WU
QIMR-WIL	MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M33nRWlEPTB;MD6wNVI3QSEQvF2=	MXLTRW5ITVJ?
SNU-C2B	MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{DnXmlEPTB;MD6wNVI4OiEQvF2=	MlX2V2FPT0WU
OCI-AML2	NE\QWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrhTWM2OD1yLkCxNlgyKM7:TR?=	NWHqTZQ5W0GQR1XS
DU-145	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTBwMEGyPUDPxE1?	MnTvV2FPT0WU
SW982	NH7qZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M371TmlEPTB;MD6wNVI6OyEQvF2=	M3e0SnNCVkeHUh?=
MFH-ino	M4XsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGOyRXZKSzVyPUCuNFEzQTNizszN	MX;TRW5ITVJ?
A427	NEPRZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXITWM2OD1yLkCxNlk6KM7:TR?=	M1;kbnNCVkeHUh?=
LCLC-97TM1	MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2O4dGlEPTB;MD6wNVMh\|ryP	NUPEWW9UW0GQR1XS
AM-38	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTBwMEGzNFIh\|ryP	NHW3PZNUSU6JRWK=
K5	NIXhVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFK1UWJKSzVyPUCuNFE{ODhizszN	M4m5NHNCVkeHUh?=
T84	M2r4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFjGXZdKSzVyPUCuNFE{OzFizszN	M{OwUHNCVkeHUh?=
TE-15	NXLkNpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfvTWM2OD1yLkCxN\|M3KM7:TR?=	MXXTRW5ITVJ?
NCI-H460	NI\5SmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEDQO4NKSzVyPUCuNFE{OzZizszN	NVXUNoc1W0GQR1XS
NTERA-S-cl-D1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPjdVRKSzVyPUCuNFE{OzlizszN	M13QdHNCVkeHUh?=
KYSE-450	NVqxPXl4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4S2VmlEPTB;MD6wNVM1QSEQvF2=	M33ETHNCVkeHUh?=
H4	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3:2cmlEPTB;MD6wNVM3PiEQvF2=	MlTrV2FPT0WU
LC-2-ad	NUHRUG1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrsVXRKSzVyPUCuNFE{PyEQvF2=	NUPoWIhOW0GQR1XS
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HCC2998	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYOw[GhiUUN3ME2wMlAzQTR3IN88US=>	MoDMV2FPT0WU
ONS-76	NFe2RYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPWVYlGUUN3ME2wMlAzQTV2IN88US=>	MVTTRW5ITVJ?
DBTRG-05MG	Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XVWGlEPTB;MD6wNlk2PSEQvF2=	NYm5eFNnW0GQR1XS
HuCCT1	NX3FbmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\5ZXNKSzVyPUCuNFI6PjFizszN	NVHYcGZPW0GQR1XS
J82	NGXnWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGKwSnpKSzVyPUCuNFMxODdizszN	NUnYUZRHW0GQR1XS
MKN28	M17SNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIjnTndKSzVyPUCuNFMxOTJizszN	M2nmPXNCVkeHUh?=
SW837	M1yyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGDjPIlKSzVyPUCuNFMxOTRizszN	MV\TRW5ITVJ?
no-10	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzE[Y1KSzVyPUCuNFMxOTZizszN	NFTWPYhUSU6JRWK=
BC-3	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTBwMEOwNVgh\|ryP	NYDnfml{W0GQR1XS
no-11	M1iz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NU\POpFQUUN3ME2wMlA{ODR6IN88US=>	MWDTRW5ITVJ?
8305C	M3;4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1vrV2lEPTB;MD6wN\|A4OiEQvF2=	NUT6WId2W0GQR1XS
COLO-679	NF7Rc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmfuTWM2OD1yLkCzNVA4KM7:TR?=	NGrwO21USU6JRWK=
CESS	M3vnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWfvSWpIUUN3ME2wMlA{OTJizszN	M1:1WHNCVkeHUh?=
BFTC-909	M{ixeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWrOZ5NmUUN3ME2wMlA{OTJ3IN88US=>	MlfwV2FPT0WU
MZ2-MEL	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWiyTFZ6UUN3ME2wMlA{OTd5IN88US=>	NH;keYZUSU6JRWK=
SW872	NUn4c2NrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWmwOXN2UUN3ME2wMlA{OjF5IN88US=>	Mke4V2FPT0WU
LB831-BLC	NXjsTJR5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfLUmRWUUN3ME2wMlA{OjF7IN88US=>	MYTTRW5ITVJ?
SK-UT-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3r1cmlEPTB;MD6wN\|IzOSEQvF2=	M1K4XXNCVkeHUh?=
NCI-H1734	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLRRVVJUUN3ME2wMlA{OjNizszN	MkfjV2FPT0WU
OVCAR-8	NG\xSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33ZR2lEPTB;MD6wN\|I5OSEQvF2=	NVz6ZYNNW0GQR1XS
NCI-H2087	M33Idmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTVWlZvUUN3ME2wMlA{Ojh7IN88US=>	NUC3Rng4W0GQR1XS
U-87-MG	M3i5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2P6ZWlEPTB;MD6wN\|I6KM7:TR?=	MnHGV2FPT0WU
BC-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2TqVmlEPTB;MD6wN\|M3PyEQvF2=	MYfTRW5ITVJ?
ES7	NGDv[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;kSXVUUUN3ME2wMlA{Ozd2IN88US=>	MkTjV2FPT0WU
Daudi	MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWP6Uo1{UUN3ME2wMlA{Ozd4IN88US=>	M4KyS3NCVkeHUh?=
RS4-11	M3i3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIL4eJFKSzVyPUCuNFM{QDNizszN	NHvqPVRUSU6JRWK=
JiyoyeP-2003	M1LVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHBVmw{UUN3ME2wMlA{Ozh6IN88US=>	NH76c4RUSU6JRWK=
BL-70	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjMN4NKSzVyPUCuNFM{QDlizszN	NVPjXHFNW0GQR1XS
OS-RC-2	M3H0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NI\vO\|JKSzVyPUCuNFM{QTZizszN	M33GPHNCVkeHUh?=
SF268	M2PMS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M37PW2lEPTB;MD6wN\|QxOSEQvF2=	MUjTRW5ITVJ?
BV-173	M{XsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk\aTWM2OD1yLkCzOFI3KM7:TR?=	MV\TRW5ITVJ?
DMS-273	NHfSbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYW5ZXRUUUN3ME2wMlA{PDd7IN88US=>	MYXTRW5ITVJ?
22RV1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{[4dmlEPTB;MD6wN\|UxPyEQvF2=	NU\pV2R3W0GQR1XS
ES8	NYTGdZZMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTBwMEO1N\|gh\|ryP	NWfSbmpzW0GQR1XS
KYSE-150	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwMEO2NFgh\|ryP	NFLySFJUSU6JRWK=
HCC1569	NH7lSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXHae3V4UUN3ME2wMlA{PjB6IN88US=>	NY\vVm5xW0GQR1XS
NB5	NW\UcncyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrvfYtNUUN3ME2wMlA{PjF\|IN88US=>	MnPJV2FPT0WU
G-402	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIT1XWFKSzVyPUCuNFM3OTRizszN	NIrLdopUSU6JRWK=
NCI-H1693	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1rkeGlEPTB;MD6wN\|YyPyEQvF2=	M3LG[HNCVkeHUh?=
LB2241-RCC	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEPMb4hKSzVyPUCuNFM3PDJizszN	MY\TRW5ITVJ?
KP-4	NHXvfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYTJR\|UxRTBwMEO2OlMh\|ryP	NGTic3lUSU6JRWK=
ML-2	MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3G3e2lEPTB;MD6wN\|Y4OSEQvF2=	M1jjbXNCVkeHUh?=
KU812	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoPWTWM2OD1yLkCzOlg1KM7:TR?=	MnK3V2FPT0WU
LS-411N	M{flWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV\DPWhXUUN3ME2wMlA{PzNzIN88US=>	MkLhV2FPT0WU
OAW-42	M4DuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTBwMEO3OFch\|ryP	MVHTRW5ITVJ?
HCC38	M2HNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3e2NmlEPTB;MD6wN\|c4OSEQvF2=	NYPkWplEW0GQR1XS
Ca-Ski	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE\MUG1KSzVyPUCuNFM4QDRizszN	NH\yeHdUSU6JRWK=
Calu-3	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTBwMEO3PFkh\|ryP	NYXUVHNGW0GQR1XS
KYSE-70	NYnNSoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NILIT5JKSzVyPUCuNFM5OTJizszN	M1zB[HNCVkeHUh?=
D-392MG	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInVdphKSzVyPUCuNFM5PDJizszN	NFPqO3JUSU6JRWK=
OVCAR-4	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGG0dXpKSzVyPUCuNFM5PThizszN	MWLTRW5ITVJ?
Detroit562	M{L5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYH5TJVyUUN3ME2wMlA{QDd{IN88US=>	MY\TRW5ITVJ?
HEL	NX\2dIVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fUSWlEPTB;MD6wN\|g6OSEQvF2=	NX;4dJRrW0GQR1XS
MONO-MAC-6	NInSZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTBwMEO4PVMh\|ryP	MVjTRW5ITVJ?
LoVo	Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{GxXGlEPTB;MD6wN\|k{OyEQvF2=	NU[wdol5W0GQR1XS
U-2-OS	MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXi0Sm4xUUN3ME2wMlA{QTN3IN88US=>	MlzIV2FPT0WU
A172	NITMZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXPJR\|UxRTBwMEO5OUDPxE1?	MlX3V2FPT0WU
OCUB-M	NYO1SVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjNTWM2OD1yLkCzPVYyKM7:TR?=	MUnTRW5ITVJ?
SW48	NEK1W4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH3EWplKSzVyPUCuNFQxOzFizszN	MXvTRW5ITVJ?
HC-1	M2PMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUDWUHFvUUN3ME2wMlA1ODZ7IN88US=>	NG\4ZYlUSU6JRWK=
KOSC-2	NH32co5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVm3bG1OUUN3ME2wMlA1OTFizszN	NHHSOpdUSU6JRWK=
HDLM-2	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml7hTWM2OD1yLkC0NVE1KM7:TR?=	NFvOOJVUSU6JRWK=
CTV-1	Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlvjTWM2OD1yLkC0NVE3KM7:TR?=	NIq1NpVUSU6JRWK=
SH-4	M4HaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV;nSI5NUUN3ME2wMlA1OTRzIN88US=>	M3jmU3NCVkeHUh?=
SW756	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUjmbFhrUUN3ME2wMlA1OTV5IN88US=>	NXXNXIMyW0GQR1XS
GCT	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;xUZdUUUN3ME2wMlA1OTZzIN88US=>	NWPYSIFXW0GQR1XS
CHL-1	NVS0N5FqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwMESxOlkh\|ryP	M2L1WXNCVkeHUh?=
LAMA-84	NGLTcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkL5TWM2OD1yLkC0NVcyKM7:TR?=	NFjFUppUSU6JRWK=
LS-1034	NXfubZFWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUnJR\|UxRTBwMESxPVEh\|ryP	MYjTRW5ITVJ?
NCI-H358	NFHrUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LpTmlEPTB;MD6wOFIyOiEQvF2=	MmLhV2FPT0WU
NB13	MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MULJR\|UxRTBwMESyNlch\|ryP	NYrDNYJbW0GQR1XS
TE-9	MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwMESyN\|ch\|ryP	NFzlU\|dUSU6JRWK=
OE33	M1PPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4Tjd2lEPTB;MD6wOFI1OSEQvF2=	M3f6enNCVkeHUh?=
CAL-120	M2jvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF7N[WpKSzVyPUCuNFQzPDFizszN	M4jwTXNCVkeHUh?=
DJM-1	NWnUeWpLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mkm1TWM2OD1yLkC0NlczKM7:TR?=	NX3u[WRqW0GQR1XS
SK-MEL-24	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1u1[mlEPTB;MD6wOFI5OyEQvF2=	M1LCdXNCVkeHUh?=
VA-ES-BJ	NVe0ZllXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYjhdGR[UUN3ME2wMlA1Ojl{IN88US=>	NEXkUHlUSU6JRWK=
MMAC-SF	MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoC2TWM2OD1yLkC0Nlk4KM7:TR?=	MljxV2FPT0WU
MZ7-mel	M4f2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHVTWM2OD1yLkC0N\|Mh\|ryP	NYW2d2dnW0GQR1XS
BxPC-3	MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTpTWM2OD1yLkC0N\|QyKM7:TR?=	M4\BVHNCVkeHUh?=
HT-29	M{TlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIfoWVBKSzVyPUCuNFQ{PTdizszN	M3vnbnNCVkeHUh?=
SK-MEL-30	NHK4dGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTBwMESzOlIh\|ryP	NHTyWJdUSU6JRWK=
CAL-33	M2LUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIjMe2NKSzVyPUCuNFQ{PzVizszN	MW\TRW5ITVJ?
COLO-680N	NV\hS4NRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fYWGlEPTB;MD6wOFQxPyEQvF2=	MlrnV2FPT0WU
NH-12	NIruU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnxToJ[UUN3ME2wMlA1PDRizszN	NV\CTGljW0GQR1XS
HCC1937	M1nad2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1u2b2lEPTB;MD6wOFQ2PiEQvF2=	MX;TRW5ITVJ?
IMR-5	NGTnUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYLJR\|UxRTBwMES0PUDPxE1?	M2nsVnNCVkeHUh?=
MC-CAR	NVPYc3hpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXfwNlBjUUN3ME2wMlA1PTZ7IN88US=>	NWj6UIJKW0GQR1XS
NCI-H747	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfiTWM2OD1yLkC0OVch\|ryP	Mn;NV2FPT0WU
NCI-H1792	NFzYXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXNbYFKSzVyPUCuNFQ2QDFizszN	MXnTRW5ITVJ?
SW13	NHOwNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXLbINKSzVyPUCuNFQ2QSEQvF2=	M1XQRnNCVkeHUh?=
MLMA	NED1d\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIrNTo1KSzVyPUCuNFQ3ODlizszN	M3fyXXNCVkeHUh?=
U251	M{fxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX21UoNuUUN3ME2wMlA1PzZ\|IN88US=>	MojpV2FPT0WU
U031	M1LNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFj2NmdKSzVyPUCuNFQ4PzFizszN	M{PGenNCVkeHUh?=
ME-180	NHfoWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTBwMES3PFIh\|ryP	NIXwSHdUSU6JRWK=
SK-MEL-3	NVjtS4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMES4NFIh\|ryP	MkjzV2FPT0WU
MOLT-4	M{Themdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXr4RmxJUUN3ME2wMlA1QDB\|IN88US=>	MYfTRW5ITVJ?
PF-382	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTHfXlKSzVyPUCuNFQ5OjZizszN	M1z1dXNCVkeHUh?=
NUGC-3	MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4G3T2lEPTB;MD6wOFgzPyEQvF2=	M3vMR3NCVkeHUh?=
NCI-H1417	M4D3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2jpS2lEPTB;MD6wOFg6KM7:TR?=	Mo\IV2FPT0WU
COLO-205	NVn0dYpiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrKcmdKSzVyPUCuNFQ6OTlizszN	NFnDbnlUSU6JRWK=
TE-441-T	Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXe4TIxFUUN3ME2wMlA1QTNizszN	NV[5d295W0GQR1XS
MKN1	M4nTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEPj[ldKSzVyPUCuNFQ6OyEQvF2=	MXfTRW5ITVJ?
UM-UC-3	NUTQbZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYHi[It5UUN3ME2wMlA1QTVizszN	M4jtW3NCVkeHUh?=
SF126	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3O0N2lEPTB;MD6wOVAyKM7:TR?=	M2TydHNCVkeHUh?=
LB1047-RCC	M3[zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoH1TWM2OD1yLkC1NFMyKM7:TR?=	NW\UU\|czW0GQR1XS
A253	NXjhRWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3n4[GlEPTB;MD6wOVA2OiEQvF2=	NFPUUVdUSU6JRWK=
NCI-H1963	MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFX2cJhKSzVyPUCuNFUyPzZizszN	NFW5XVZUSU6JRWK=
VM-CUB-1	NHv2ZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwMEWzNVEh\|ryP	MYnTRW5ITVJ?
T-24	M2ThSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH3MZodKSzVyPUCuNFU{QDRizszN	M3fkZXNCVkeHUh?=
K-562	MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXuPWtKSzVyPUCuNFU{QDdizszN	M{jIVXNCVkeHUh?=
ARH-77	MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXkTWM2OD1yLkC1N\|k2KM7:TR?=	M4XXeXNCVkeHUh?=
CA46	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMEW0N{DPxE1?	MXvTRW5ITVJ?
HCC70	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{\EeGlEPTB;MD6wOVQ2OiEQvF2=	M3rJVXNCVkeHUh?=
ST486	NV6wWWY1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rFcmlEPTB;MD6wOVUzPSEQvF2=	MUPTRW5ITVJ?
COLO-741	NIfvPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPIfYpDUUN3ME2wMlA2PTNzIN88US=>	NUj6fFVsW0GQR1XS
SK-PN-DW	NGm3SlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEPFe2hKSzVyPUCuNFU2QDhizszN	NFexUY9USU6JRWK=
BL-41	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fNdWlEPTB;MD6wOVU6PiEQvF2=	NYDEb3R4W0GQR1XS
D-263MG	MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTBwMEW2PFMh\|ryP	MkjRV2FPT0WU
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NCI-H661	Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3fZZmlEPTB;MD6xNVE6PSEQvF2=	NIPUVFZUSU6JRWK=
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PC-3	NIPrU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWfzXplpUUN3ME2wMlE{OTd5IN88US=>	M1;FPHNCVkeHUh?=
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KARPAS-422	MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwMUSwN\|ch\|ryP	MYDTRW5ITVJ?
OVCAR-3	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{jhUmlEPTB;MD6xOFA4QCEQvF2=	Mn3QV2FPT0WU
NCI-H1092	Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUXJR\|UxRTBwMUSxNFEh\|ryP	MlSwV2FPT0WU
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HD-MY-Z	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2[xZmlEPTB;MD6xOFQzQSEQvF2=	M1;OZ3NCVkeHUh?=
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NCI-H2081	MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTBwMUWyNVgh\|ryP	M1PCPHNCVkeHUh?=
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COR-L279	MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vHbWlEPTB;MD6xOVg{PiEQvF2=	NFrDXIJUSU6JRWK=
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CAL-72	NFPGXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;4eWVyUUN3ME2wMlE3PTlizszN	MV3TRW5ITVJ?
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COR-L88	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIPJ[GVKSzVyPUCuNVcyOTRizszN	Mn74V2FPT0WU
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MDA-MB-134-VI	MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MorHTWM2OD1yLkG3N\|Y4KM7:TR?=	MUDTRW5ITVJ?
NCI-H596	NV\TZ25vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVv0U2hGUUN3ME2wMlE4OzhizszN	MVvTRW5ITVJ?
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EGI-1	NWnKPFYyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGe1UIhKSzVyPUCuNVc6PyEQvF2=	Mn;GV2FPT0WU
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MDA-MB-415	M4HMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYXJWZZUUUN3ME2wMlE6PzR6IN88US=>	M2XXfnNCVkeHUh?=
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LU-65	M1T2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\lWpdvUUN3ME2wMlIxOjFzIN88US=>	M3faZXNCVkeHUh?=
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NCI-H2196	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTBwMkG3OFch\|ryP	MVHTRW5ITVJ?
M14	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\oTpM1UUN3ME2wMlIyQDB\|IN88US=>	MmPwV2FPT0WU
NCI-H1436	M3\UWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1roemlEPTB;MD6yNVgzPiEQvF2=	MWfTRW5ITVJ?
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KARPAS-299	M{S0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTBwMkK5PVQh\|ryP	NEiyNGRUSU6JRWK=
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NCI-H838	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULtNZV6UUN3ME2wMlI{PzF2IN88US=>	MUPTRW5ITVJ?
NB10	M2Lyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2\xc2lEPTB;MD6yN\|c{OSEQvF2=	MXHTRW5ITVJ?
NCI-H2141	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LReGlEPTB;MD6yN\|g1OSEQvF2=	MkDkV2FPT0WU
LB647-SCLC	Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTBwMkSwNVQh\|ryP	Mom4V2FPT0WU
NCI-H23	M4nSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrYSpRKSzVyPUCuNlQxPTlizszN	MXfTRW5ITVJ?
MN-60	M4j1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHCRoNjUUN3ME2wMlI1OjN7IN88US=>	NY\qTWVUW0GQR1XS
CAL-148	M{TWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTBwMkSyPFIh\|ryP	NXLqWoZVW0GQR1XS
EFE-184	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrJbINKSzVyPUCuNlQ2QTdizszN	M{P4R3NCVkeHUh?=
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MHH-NB-11	Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTBwMkWzOUDPxE1?	NXzVPWpbW0GQR1XS
DOK	NHjMSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHjcJpEUUN3ME2wMlI2QTNizszN	M4HJSnNCVkeHUh?=
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NCI-H69	NWLWUoo1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTBwMkeyNFEh\|ryP	NVPHUZVMW0GQR1XS
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NCI-H1618	MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGO3XZZKSzVyPUCuNlc2OSEQvF2=	Mom5V2FPT0WU
NCI-SNU-5	MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2TRNWlEPTB;MD6yO\|YyOyEQvF2=	NUTDXGRHW0GQR1XS
NCI-H1694	M1;6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMke3N\|Mh\|ryP	Mm\LV2FPT0WU
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SW684	NYW3UldNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTBwMkizPFMh\|ryP	NXLoU5dCW0GQR1XS
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NCI-H510A	NETUWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1L4U2lEPTB;MD6yPVMxPCEQvF2=	MmXBV2FPT0WU
Mo-T	NGLyXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHRNmdKSzVyPUCuNlk{OzFizszN	MlrvV2FPT0WU
LB373-MEL-D	M1iy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLjOVZMUUN3ME2wMlI6PDNzIN88US=>	MWjTRW5ITVJ?
NCI-H28	NUWwUYU1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkTxTWM2OD1yLkK5PFM4KM7:TR?=	NF7HXnJUSU6JRWK=
NCI-H446	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2jpfGlEPTB;MD6yPVkzOSEQvF2=	MVXTRW5ITVJ?
L-540	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDUeHdKSzVyPUCuN\|AxQDlizszN	M3K2SHNCVkeHUh?=
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BT-20	M2XXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXzPcXI{UUN3ME2wMlMyODl7IN88US=>	M{XQWXNCVkeHUh?=
KP-N-YN	M1zCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTBwM{GxNVgh\|ryP	MXvTRW5ITVJ?
MDA-MB-175-VII	MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwM{KzOFgh\|ryP	M4f4enNCVkeHUh?=
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COLO-678	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwM{OzPFkh\|ryP	MkPvV2FPT0WU
COLO-829	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXfJR\|UxRTBwM{S0OVIh\|ryP	MV3TRW5ITVJ?
A704	NUntXHc5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXIe4VbUUN3ME2wMlM1QTJ\|IN88US=>	MoC3V2FPT0WU
NCI-H719	M4nnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWnJR\|UxRTBwM{WxNlQh\|ryP	MVTTRW5ITVJ?
MFE-280	NV7re3B5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\HXGdKSzVyPUCuN\|U4OTVizszN	NGe3cIxUSU6JRWK=
DMS-114	M374fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFu5[WZKSzVyPUCuN\|YyOiEQvF2=	M4WxcXNCVkeHUh?=
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HPAF-II	NG\SemtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFTqT\|hKSzVyPUCuOFEyOTdizszN	Mk[wV2FPT0WU
NCI-H1882	MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTETWM2OD1yLkSxO\|g1KM7:TR?=	M4DCZnNCVkeHUh?=
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MHH-CALL-2	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTBwNES4N{DPxE1?	NXvjUo9oW0GQR1XS
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NEC8	NIjIVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVTQRllVUUN3ME2wMlQ2OTR3IN88US=>	NFLybW9USU6JRWK=
UACC-812	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4ntfWlEPTB;MD60Olc4PiEQvF2=	MoOxV2FPT0WU
D-502MG	NHW0N3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTtTWM2OD1yLkS4NFMh\|ryP	M37JZnNCVkeHUh?=
CaR-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4rHe2lEPTB;MD61NFM3PyEQvF2=	M4XBUXNCVkeHUh?=
LU-139	M4rWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfDTWM2OD1yLkWxOFU4KM7:TR?=	NX\LclNFW0GQR1XS
RPMI-8402	NYS1WZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTBwNUKyNFch\|ryP	NUXnO45[W0GQR1XS
SW1088	NEXPVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWT4SWY6UUN3ME2wMlU{QDZ7IN88US=>	MYfTRW5ITVJ?
JVM-3	MlHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTHTWM2OD1yLkW0NVE4KM7:TR?=	NGXpbFFUSU6JRWK=
YAPC	MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPVTWM2OD1yLkW1NlEyKM7:TR?=	NUn6eIF7W0GQR1XS
KG-1	M1HlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHn6TVlKSzVyPUCuOVU6QDRizszN	MoPqV2FPT0WU
C32	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTBwNUezNVMh\|ryP	M4TleXNCVkeHUh?=
IST-SL1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjXR\|I2UUN3ME2wMlYxPDN3IN88US=>	M4G2XXNCVkeHUh?=
NCI-H2126	NEXsSFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33Ub2lEPTB;MD62N\|E2OiEQvF2=	M1y0bnNCVkeHUh?=
HCC1954	M1jsSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnX1TWM2OD1yLk[0O\|I3KM7:TR?=	M1rNfnNCVkeHUh?=
WM-115	NVXnbGxbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlzHTWM2OD1yLk[1NFkzKM7:TR?=	MoG4V2FPT0WU
NB6	NEn4TlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTlTWM2OD1yLk[3N\|M2KM7:TR?=	MmflV2FPT0WU
TYK-nu	M3rUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTBwNke5OVIh\|ryP	NWPFSFJ1W0GQR1XS
KY821	NX3WfXVqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3H2bWlEPTB;MD63NFIzQSEQvF2=	NGj4eI5USU6JRWK=
SIMA	Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPGVYNKSzVyPUCuO\|E4OTlizszN	M2n1cXNCVkeHUh?=
RCC10RGB	NIXIVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTBwN{G5NVgh\|ryP	NF7QRlRUSU6JRWK=
LN-405	NVXaPJJvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWrJR\|UxRTBwN{SzOkDPxE1?	NVH6[Y54W0GQR1XS
NCI-H1155	NV3sXnZrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1rKS2lEPTB;MD63OFg3QCEQvF2=	MXTTRW5ITVJ?
SCLC-21H	NHzOPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX\JR\|UxRTBwN{[5NFMh\|ryP	MnPYV2FPT0WU
DMS-79	NWjiWWNtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn7YTWM2OD1yLke3PFQ2KM7:TR?=	M{fjUHNCVkeHUh?=
EC-GI-10	NV74SVR2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Moe5TWM2OD1yLke3PVc2KM7:TR?=	MknwV2FPT0WU
KNS-42	MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXBTWM2OD1yLke4PFMyKM7:TR?=	M4\TcnNCVkeHUh?=
SNU-475	NW\FUo9zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjzTWM2OD1yLke5NlAzKM7:TR?=	MlXpV2FPT0WU
SF539	M37HR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTvTWM2OD1yLke5PVI2KM7:TR?=	NEDMS5JUSU6JRWK=
SW1417	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LQfmlEPTB;MD64NVM{QSEQvF2=	MU\TRW5ITVJ?
ATN-1	M1vIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7MOYNKSzVyPUCuPFUyOTVizszN	NVjhNY1rW0GQR1XS
PLC-PRF-5	NHjkXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHtTWM2OD1yLki4OFc2KM7:TR?=	NX\s[3dzW0GQR1XS
HT-3	NF\tTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XYUGlEPTB;MD64PVQzKM7:TR?=	MVXTRW5ITVJ?
MDA-MB-453	NF65fHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVTFOFhlUUN3ME2wMlkxOzB2IN88US=>	NUP1[JBkW0GQR1XS
HAL-01	NYXjRnpJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmK5TWM2OD1yLkm5N\|c6KM7:TR?=	NGjBbnRUSU6JRWK=
NCI-H1993	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTFwMES2OVch\|ryP	M1nncXNCVkeHUh?=
NCI-H2227	M4DBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUfJR\|UxRTFwMES5PFEh\|ryP	MUfTRW5ITVJ?
LP-1	NEDPPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkOyTWM2OD1zLkC2PVMh\|ryP	NGrUeVRUSU6JRWK=
P31-FUJ	M{XHWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mki3TWM2OD1zLkGwO\|Y3KM7:TR?=	M2TOZnNCVkeHUh?=
NCI-H64	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTFwMUW0NkDPxE1?	MnrTV2FPT0WU
SW1463	Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYr6VlhUUUN3ME2xMlE5OzR7IN88US=>	M1TlO3NCVkeHUh?=
SK-MEL-1	MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\MfXBHUUN3ME2xMlIxPTl3IN88US=>	NVjkUYNiW0GQR1XS
TALL-1	M{TFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTFwMkWxOlUh\|ryP	NXv5[IZ[W0GQR1XS
RO82-W-1	NITscW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXETWM2OD1zLkOzN\|M6KM7:TR?=	MkfyV2FPT0WU
NCI-H1581	NYnPTVVzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1LsOmlEPTB;MT6zOVY5PyEQvF2=	M1HsVnNCVkeHUh?=
NCI-H748	NYXieoZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEjtV2FKSzVyPUGuN\|U4OzhizszN	M37hWXNCVkeHUh?=
HCC1187	MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnsTWM2OD1zLkW1OVIzKM7:TR?=	NUT1fHg{W0GQR1XS
EoL-1-cell	M{\HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVjJR\|UxRTFwNUi4PFkh\|ryP	NVnwe\|hUW0GQR1XS
HuO-3N1	M{\4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jke2lEPTB;MT64N\|QyOiEQvF2=	M2PaTXNCVkeHUh?=
NCI-H1793	MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTFwOEe1PVMh\|ryP	NFnodo5USU6JRWK=
Caov-3	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTJwMEC2NlUh\|ryP	NHGyd5ZUSU6JRWK=
JAR	M4fIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4nJeGlEPTB;Mj6wO\|kzKM7:TR?=	MlLJV2FPT0WU
SK-MEL-28	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYLJR\|UxRTJwMUiwPVgh\|ryP	NX3RRZFYW0GQR1XS
EM-2	NE\TbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjQTWM2OD1{LkKwNlk{KM7:TR?=	MkHmV2FPT0WU
Mewo	M1P2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXy4[ZZZUUN3ME2yMlIzOjZ3IN88US=>	NIjRN5VUSU6JRWK=
NCI-H720	NELEemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvBUJJHUUN3ME2yMlI3PTh3IN88US=>	M1fpbXNCVkeHUh?=
CAL-54	M1vtemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlLGTWM2OD1{LkK2O\|k2KM7:TR?=	NH;C[5lUSU6JRWK=
MC116	NUXFSploT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnzXTWM2OD1{LkO2N\|k4KM7:TR?=	NUjuXWw5W0GQR1XS
DG-75	NHfzeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHn5TItKSzVyPUKuOFg2PzZizszN	M3y0ZXNCVkeHUh?=
HCC1143	MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTJwNUC2OVgh\|ryP	NVPvdY1qW0GQR1XS
FTC-133	MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2ntUmlEPTB;Mj61N\|Y5QSEQvF2=	M2W5eXNCVkeHUh?=
AsPC-1	NXnROHViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFfPeINKSzVyPUKuOVM6OjlizszN	NXnEcHYxW0GQR1XS
NCI-H889	NHHPSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13PSGlEPTB;Mj61OlcxPiEQvF2=	NYmwfoQ4W0GQR1XS
HT55	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYi2OFZ1UUN3ME2yMlYzODF7IN88US=>	M3:zfHNCVkeHUh?=
UMC-11	NXn1[Y9ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTJwN{i3NVUh\|ryP	M4jUVnNCVkeHUh?=
P12-ICHIKAWA	Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLQOpRMUUN3ME2yMlgzODR4IN88US=>	MXzTRW5ITVJ?
HCC1395	MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTJwOUi2NFIh\|ryP	NHrycI1USU6JRWK=
D-283MED	M4e3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFW0O21KSzVyPUOuNVg6OzdizszN	NU\r[YxuW0GQR1XS
COLO-800	M3LZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4rSXGlEPTB;Mz6zN\|g6PyEQvF2=	MkHnV2FPT0WU
MFM-223	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4HNXmlEPTB;Mz6zOlA6PyEQvF2=	M1PVdXNCVkeHUh?=
TE-5	M2XSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV7wUIZ2UUN3ME20MlU3OTR5IN88US=>	M{ewb3NCVkeHUh?=
NCI-H209	Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MluxTWM2OD12Lke4OVczKM7:TR?=	M1zBcnNCVkeHUh?=
SiHa	NIewZ\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{Xoe2lEPTB;ND65OVIxOyEQvF2=	M4\CdHNCVkeHUh?=
NCI-H1395	Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrYNm9mUUN3ME21MlExPjN\|IN88US=>	NXvablczW0GQR1XS
A498	NIiz[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NU\TfYxEUUN3ME21MlIyOjVzIN88US=>	NWTBeVl1W0GQR1XS
ES5	NID2WoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFPJWHJKSzVyPUWuOlEyPzhizszN	NX;L[mt1W0GQR1XS
MDA-MB-157	NWjMPGpQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTVwNk[0OFMh\|ryP	M1vUdHNCVkeHUh?=
NCI-H1623	NUP2WXROT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPTTWM2OD13LkizOVU3KM7:TR?=	MV\TRW5ITVJ?
RPMI-8866	NFXE[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\HbYdlUUN3ME21Mlg1Pzl{IN88US=>	NXHBV4d[W0GQR1XS
LC-1F	M2HU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml76TWM2OD14LkC5NlkyKM7:TR?=	NEfi[nZUSU6JRWK=
TCCSUP	M333PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTT[IhCUUN3ME22MlYxOzR7IN88US=>	MUTTRW5ITVJ?
TT	MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnS3TWM2OD16LkOzNFA6KM7:TR?=	Mn3vV2FPT0WU
NCI-H1838	NWHyWXQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRThwNUG3N\|Eh\|ryP	M4\QXHNCVkeHUh?=
NCI-H322M	M2XPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlX3TWM2OD17LkG2NlgyKM7:TR?=	NULIXI93W0GQR1XS
NCI-H187	M3rFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYLJR\|UxRTlwNUG4N\|Uh\|ryP	MlTJV2FPT0WU
SBC-1	NXvjRVVlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYjDS4w{UUN3ME25Mlk{PjV4IN88US=>	NHvMOnZUSU6JRWK=
SCC-3	NUC5[FJST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4LzZ2lEPTB;MUCuOVY4QSEQvF2=	NU[4VmlyW0GQR1XS
SW948	NYj4SZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;aW25uUUN3ME2xNE44PTFzIN88US=>	Ml30V2FPT0WU
CPC-N	MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MULJR\|UxRTFzLkCwO{DPxE1?	NIDFcIRUSU6JRWK=
TGBC24TKB	NV;0N\|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYnJR\|UxRTF\|LkWyPUDPxE1?	NIjCR3pUSU6JRWK=
NCI-H2452	NYPvSHNET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1ftcGlEPTB;MUSuO\|Mh\|ryP	NIm0do5USU6JRWK=
Hs-578-T	M3Ple2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVjJR\|UxRTF6LkW3OVkh\|ryP	M3;PcHNCVkeHUh?=
DV-90	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTF6Lkm5OFUh\|ryP	NXXqcGw5W0GQR1XS
NCI-H1563	NUC3V2pTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlnNTWM2OD1zOT63PFg5KM7:TR?=	MWrTRW5ITVJ?
SW780	M4Ht[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nmRmlEPTB;MkGuNVMyQCEQvF2=	Mnn5V2FPT0WU
NCI-H345	M4TY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfmcYhnUUN3ME2yNU45Pzd7IN88US=>	M3zTenNCVkeHUh?=
LB771-HNC	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLMTWM2OD1{Mj60PFE{KM7:TR?=	MV7TRW5ITVJ?
RT4	NXyxVoxTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojsTWM2OD1{Mz6zNlgzKM7:TR?=	M13TdXNCVkeHUh?=
NCI-H82	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MljoTWM2OD1{Mz61OVI3KM7:TR?=	M2GzUHNCVkeHUh?=
NCI-H524	M{ThNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkjUTWM2OD1{ND6zPFEzKM7:TR?=	MljWV2FPT0WU
SNU-C1	MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1LQNWlEPTB;MkSuPVExPSEQvF2=	MVnTRW5ITVJ?
NCI-SNU-16	NFXLdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHzhWppKSzVyPUS4MlMyPDJizszN	M1rRZXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; PubMed: 23993685 Mol Oncol Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein. E-cadherin / Cleaved PARP / Bim; PubMed: 23993685 Mol Oncol Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein. HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; PubMed: 24796583 Oncotarget CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control. CDK4 / HMGA2 ; PubMed: 26893968 PeerJ HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.	23993685 24796583 26893968
Growth inhibition assay	Cell viability; PubMed: 26893968 PeerJ Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. p < 0.05, p < 0.01, **p < 0.001. All experiments were performed in three independent experiments.	26893968

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	+ Expand Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	+ Expand Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	+ Expand Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on )

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01772797	Completed	Drug: LDK378\|Drug: AUY922	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Drug: AUY922	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Drug: AUY922\|Drug: BYL719	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1
NCT01484860	Terminated	Drug: AUY922	Adenocarcinoma of the Pancreas\|Metastatic Disease	University Health Network Toronto\|Novartis Pharmaceuticals	January 2012	Phase 2
NCT01402401	Terminated	Drug: AUY922 + Trastuzumab	Advanced Gastric Cancer	Novartis Pharmaceuticals\|Novartis	November 2011	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 44 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on )

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 44 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on )

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)