Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 24 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062

Nat Commun, 2014, 5:3361

PubMed: 24553445

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778

Mol Cancer, 2011, 10:125

PubMed: 21962244

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393
J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253

Molecules, 2015, 20(1):1643-60

PubMed: 25608045

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909

PLoS One, 2014, 9(12):e114506

PubMed: 25503774

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed:

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed:

3 Customer Reviews

U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.
Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922 (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjEOmNKSzVyPUCuNFAxOTJ3IN88US=>	NHv3dFJUSU6JRWK=
MV-4-11	NELPSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{i1WmlEPTB;MD6wNFA2PThizszN	NUj4cpVkW0GQR1XS
NALM-6	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMECwPFQzKM7:TR?=	NEHjV2RUSU6JRWK=
HOS	M2roNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnW5TWM2OD1yLkCwNVM5KM7:TR?=	NGOwcXRUSU6JRWK=
HT-144	M33wSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwMECxOVUh\|ryP	NEDEUnlUSU6JRWK=
SW1710	NWfGbmt[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn3vTWM2OD1yLkCwNVg3KM7:TR?=	M2TBTXNCVkeHUh?=
TE-8	NWfOeHpQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXVTWM2OD1yLkCwNlM4KM7:TR?=	NGHBc4FUSU6JRWK=
ES1	NVzEOmJuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYHrVoh5UUN3ME2wMlAxOjZ4IN88US=>	NV7tcIMzW0GQR1XS
CCF-STTG1	MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX;JR\|UxRTBwMECyPVch\|ryP	MX\TRW5ITVJ?
PSN1	NYTrNXozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYnJR\|UxRTBwMECzNVgh\|ryP	MkP5V2FPT0WU
CAL-51	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH7oWVFKSzVyPUCuNFA{OjVizszN	MoXjV2FPT0WU
MCF7	M2HaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTBwMECzN\|Uh\|ryP	NV;sZlBXW0GQR1XS
SK-HEP-1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTBwMECzN\|Yh\|ryP	NYXMWXplW0GQR1XS
LCLC-103H	NVXOPFRnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3nSZmlEPTB;MD6wNFQ{KM7:TR?=	NHzFTZVUSU6JRWK=
HMV-II	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XWO2lEPTB;MD6wNFQ1QSEQvF2=	NELoNlRUSU6JRWK=
MES-SA	M3\HdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnDcItKSzVyPUCuNFA1PTJizszN	M4TUcnNCVkeHUh?=
SK-LMS-1	NWGwU\|ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mm\PTWM2OD1yLkCwOFU5KM7:TR?=	M2mzV3NCVkeHUh?=
639-V	MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2fSd2lEPTB;MD6wNFQ5PSEQvF2=	MlfFV2FPT0WU
SIG-M5	NXnhe5RkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjFTWM2OD1yLkCwOFg6KM7:TR?=	MkXyV2FPT0WU
LOUCY	NYGxc2pQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVTVR25WUUN3ME2wMlAxPTB3IN88US=>	M3\hTHNCVkeHUh?=
HSC-2	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2TRZmlEPTB;MD6wNFUyQCEQvF2=	NGXxcmRUSU6JRWK=
EW-13	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTBwMEC1NVgh\|ryP	NEntSVFUSU6JRWK=
RT-112	NGq2b3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTBwMEC1N\|Uh\|ryP	M2P1OnNCVkeHUh?=
NKM-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIOyTGVKSzVyPUCuNFA2PDdizszN	NV;0dIJbW0GQR1XS
KYSE-180	MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYrJR\|UxRTBwMEC1PFYh\|ryP	NHnKfVJUSU6JRWK=
SW1783	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUnLOINPUUN3ME2wMlAxPTlzIN88US=>	NEnqdJpUSU6JRWK=
A431	NXvvTG1xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF3kdXhKSzVyPUCuNFA3ODdizszN	Ml;nV2FPT0WU
SK-OV-3	M2rRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlnUTWM2OD1yLkCwOlMh\|ryP	M{K4[XNCVkeHUh?=
RPMI-7951	NHPkeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUHacWtGUUN3ME2wMlAxPjNzIN88US=>	MUPTRW5ITVJ?
Capan-2	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3i0NWlEPTB;MD6wNFY{QCEQvF2=	NH:5fWFUSU6JRWK=
HSC-3	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\3OWlMUUN3ME2wMlAxPjRzIN88US=>	MU\TRW5ITVJ?
786-0	NGDtR2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPPZ2Y6UUN3ME2wMlAxPjZ\|IN88US=>	MXHTRW5ITVJ?
Daoy	MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTBwMEC2PVUh\|ryP	NHzoPFBUSU6JRWK=
KGN	MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVrseHBDUUN3ME2wMlAxPzB\|IN88US=>	MY\TRW5ITVJ?
EW-16	M3j4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUnZS5o3UUN3ME2wMlAxPzR7IN88US=>	NIW3b\|RUSU6JRWK=
EW-7	M2XrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkDyTWM2OD1yLkCwO\|U1KM7:TR?=	NVLvRZlNW0GQR1XS
IGROV-1	MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH[1TYZKSzVyPUCuNFA5OTRizszN	MVnTRW5ITVJ?
8505C	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2TrVGlEPTB;MD6wNFgzOSEQvF2=	MmG1V2FPT0WU
RKO	M1P5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NULpWnhWUUN3ME2wMlAxQDJ4IN88US=>	M4j0OXNCVkeHUh?=
GDM-1	MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlqxTWM2OD1yLkCwPFQh\|ryP	MVXTRW5ITVJ?
IST-MEL1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGG5RWRKSzVyPUCuNFA5PTJizszN	MnzvV2FPT0WU
RPMI-6666	MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTBwMEC4OVIh\|ryP	NEnEdGVUSU6JRWK=
SNG-M	M3z5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2HvZ2lEPTB;MD6wNFg2PiEQvF2=	NUfHZnl3W0GQR1XS
KS-1	M1TBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1Xn[2lEPTB;MD6wNFg2QSEQvF2=	NGTuSmlUSU6JRWK=
RXF393	M2D4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWC3XplsUUN3ME2wMlAxQDZizszN	MlnlV2FPT0WU
CAL-12T	MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXjJR\|UxRTBwMEC5NlIh\|ryP	M4X0RXNCVkeHUh?=
BFTC-905	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwMEC5N\|gh\|ryP	M3v0VXNCVkeHUh?=
SK-MES-1	MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXridG5rUUN3ME2wMlAxQTR3IN88US=>	MYTTRW5ITVJ?
BB30-HNC	Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3nONmlEPTB;MD6wNFk2OiEQvF2=	MlP1V2FPT0WU
AN3-CA	NH3NVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX\JR\|UxRTBwMEGwNVch\|ryP	NXTTd3FqW0GQR1XS
EFO-27	MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDBfoZjUUN3ME2wMlAyODF5IN88US=>	NHfCNINUSU6JRWK=
G-401	MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NW\KPHI{UUN3ME2wMlAyODJ3IN88US=>	NEDYZVJUSU6JRWK=
BPH-1	MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{j5NGlEPTB;MD6wNVA{KM7:TR?=	MX7TRW5ITVJ?
NCI-H727	M{n1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17iWmlEPTB;MD6wNVA{KM7:TR?=	MVHTRW5ITVJ?
SNU-423	M4Tsd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk\hTWM2OD1yLkCxNFU{KM7:TR?=	MXjTRW5ITVJ?
KYSE-270	M3Gxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYnJR\|UxRTBwMEGwOVkh\|ryP	NE\VeFBUSU6JRWK=
AGS	M2SyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;ZTWM2OD1yLkCxNFYyKM7:TR?=	M2XNdnNCVkeHUh?=
NCI-H2228	NVL4VIlVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTBwMEGwOlQh\|ryP	MkfSV2FPT0WU
SW954	NWfDcnd{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVnJR\|UxRTBwMEGwO\|Eh\|ryP	NU\HUXJiW0GQR1XS
769-P	NWHvNW9CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\4cGlEPTB;MD6wNVA4OyEQvF2=	NXHSbZlOW0GQR1XS
BB49-HNC	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{D5S2lEPTB;MD6wNVA4PyEQvF2=	NF;6R2NUSU6JRWK=
IA-LM	NHTDdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTBwMEGwPFYh\|ryP	MYrTRW5ITVJ?
NB69	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzIPYdCUUN3ME2wMlAyOTB{IN88US=>	MUPTRW5ITVJ?
C8166	NUDJU3hJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYL5e4lVUUN3ME2wMlAyOTJ7IN88US=>	M2iyS3NCVkeHUh?=
NCI-H1299	M3nEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mof3TWM2OD1yLkCxNVU1KM7:TR?=	NIT3e5VUSU6JRWK=
YKG-1	NIPsdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{\xemlEPTB;MD6wNVE3KM7:TR?=	NH\yUFRUSU6JRWK=
PANC-03-27	NXTyWGdjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3FTWM2OD1yLkCxNVYzKM7:TR?=	NV7YWIhwW0GQR1XS
YT	M{HqNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWPJR\|UxRTBwMEGxO\|kh\|ryP	MWrTRW5ITVJ?
CAL-85-1	NYTlOoZVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{nHWWlEPTB;MD6wNVE6OiEQvF2=	NHLQR3BUSU6JRWK=
GT3TKB	M1HVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXzhSGoxUUN3ME2wMlAyOjB{IN88US=>	M17heXNCVkeHUh?=
BB65-RCC	NELT[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrBPIh2UUN3ME2wMlAyOjB2IN88US=>	NXjQdno5W0GQR1XS
ES6	NVj4XFVlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mlv5TWM2OD1yLkCxNlYyKM7:TR?=	MYLTRW5ITVJ?
MHH-ES-1	M2Hzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{Hme2lEPTB;MD6wNVI3OyEQvF2=	NFLjXlVUSU6JRWK=
QIMR-WIL	MnzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTBwMEGyOlkh\|ryP	MmfoV2FPT0WU
SNU-C2B	M1vsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPOTWM2OD1yLkCxNlczKM7:TR?=	M3fkcnNCVkeHUh?=
OCI-AML2	M2PsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIOxdGNKSzVyPUCuNFEzQDFizszN	MVfTRW5ITVJ?
DU-145	MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjVPXFKSzVyPUCuNFEzQSEQvF2=	NIHFXlJUSU6JRWK=
SW982	NYX2NlUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWPhSYtoUUN3ME2wMlAyOjl\|IN88US=>	MXzTRW5ITVJ?
MFH-ino	NELiXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEWwVWRKSzVyPUCuNFEzQTNizszN	MmfVV2FPT0WU
A427	MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7nW3pKSzVyPUCuNFEzQTlizszN	NHqwZo5USU6JRWK=
LCLC-97TM1	NFLIeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUj6WXdrUUN3ME2wMlAyOyEQvF2=	MV;TRW5ITVJ?
AM-38	NFGxe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPCOYZnUUN3ME2wMlAyOzB{IN88US=>	MknKV2FPT0WU
K5	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTBwMEGzNFgh\|ryP	MoLQV2FPT0WU
T84	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIW2WYhKSzVyPUCuNFE{OzFizszN	NGPLWmRUSU6JRWK=
TE-15	MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGj6TnNKSzVyPUCuNFE{OzZizszN	MVTTRW5ITVJ?
NCI-H460	Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3u4WWlEPTB;MD6wNVM{PiEQvF2=	MnPoV2FPT0WU
NTERA-S-cl-D1	NFrpRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2XBXWlEPTB;MD6wNVM{QSEQvF2=	NHHw[ZpUSU6JRWK=
KYSE-450	NIHVRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTBwMEGzOFkh\|ryP	M33VWnNCVkeHUh?=
H4	Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFu0SYhKSzVyPUCuNFE{PjZizszN	NEnLVnhUSU6JRWK=
LC-2-ad	Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVzybW45UUN3ME2wMlAyOzdizszN	MVnTRW5ITVJ?
GAMG	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnrWTWM2OD1yLkCxN\|cyKM7:TR?=	MkTsV2FPT0WU
TK10	M{TET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4Lu[2lEPTB;MD6wNVM5OiEQvF2=	MYrTRW5ITVJ?
NCI-H2122	NVS4e4hVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4LSSmlEPTB;MD6wNVM5PCEQvF2=	NEWxU4dUSU6JRWK=
KM12	MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\vTWM2OD1yLkCxN\|k6KM7:TR?=	MYfTRW5ITVJ?
CAL-39	NXPwNmhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTBwMEG0NkDPxE1?	MlO4V2FPT0WU
RPMI-2650	NYC0N\|RWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTBwMEG0N\|Ih\|ryP	MkLiV2FPT0WU
KYSE-510	M3q0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnzPTWM2OD1yLkCxOFQzKM7:TR?=	MojiV2FPT0WU
KALS-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXLU[mJxUUN3ME2wMlAyPDZ4IN88US=>	NWDSUXFuW0GQR1XS
NCI-H1648	M1TKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTBwMEG0PVkh\|ryP	NFriUphUSU6JRWK=
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NCI-H2009	M33ZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYXRO4JsUUN3ME2wMlAzPzZizszN	MUnTRW5ITVJ?
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BC-3	M2LUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2fsSmlEPTB;MD6wN\|AyQCEQvF2=	NWXXOW1[W0GQR1XS
no-11	MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfqV\|FlUUN3ME2wMlA{ODR6IN88US=>	MkHuV2FPT0WU
8305C	NWH1WoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTJSmFKSzVyPUCuNFMxPzJizszN	MYfTRW5ITVJ?
COLO-679	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHzfGxSUUN3ME2wMlA{OTB5IN88US=>	M3jIV3NCVkeHUh?=
CESS	M1zabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlS1TWM2OD1yLkCzNVIh\|ryP	MmrLV2FPT0WU
BFTC-909	M1XBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFu5Z\|dKSzVyPUCuNFMyOjVizszN	NE\ZbW5USU6JRWK=
MZ2-MEL	NYr2PFNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mmm1TWM2OD1yLkCzNVc4KM7:TR?=	M1zyWHNCVkeHUh?=
SW872	NWTBUpViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\PPGlEPTB;MD6wN\|IyPyEQvF2=	M{X3VXNCVkeHUh?=
LB831-BLC	M2r1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUXJR\|UxRTBwMEOyNVkh\|ryP	Ml\3V2FPT0WU
SK-UT-1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDiPFhKSzVyPUCuNFMzOjFizszN	M{PZd3NCVkeHUh?=
NCI-H1734	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFv2fotKSzVyPUCuNFMzOyEQvF2=	MlzwV2FPT0WU
OVCAR-8	MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jVS2lEPTB;MD6wN\|I5OSEQvF2=	M4LPU3NCVkeHUh?=
NCI-H2087	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULHeVNrUUN3ME2wMlA{Ojh7IN88US=>	NHfCRlRUSU6JRWK=
U-87-MG	NV65doVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3jCPWlEPTB;MD6wN\|I6KM7:TR?=	NVLueodUW0GQR1XS
BC-1	NF;0SmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjuR21vUUN3ME2wMlA{OzZ5IN88US=>	MWrTRW5ITVJ?
ES7	M3nscGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MojiTWM2OD1yLkCzN\|c1KM7:TR?=	MVrTRW5ITVJ?
Daudi	M2XDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHuZVhKSzVyPUCuNFM{PzZizszN	MYHTRW5ITVJ?
RS4-11	NEPhTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUfJR\|UxRTBwMEOzPFMh\|ryP	MkKxV2FPT0WU
JiyoyeP-2003	MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTBwMEOzPFgh\|ryP	MoHUV2FPT0WU
BL-70	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nPfWlEPTB;MD6wN\|M5QSEQvF2=	MV7TRW5ITVJ?
OS-RC-2	MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTBwMEOzPVYh\|ryP	NVTiVIpkW0GQR1XS
SF268	Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2jlSGlEPTB;MD6wN\|QxOSEQvF2=	NFywU3ZUSU6JRWK=
BV-173	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWL1dmJvUUN3ME2wMlA{PDJ4IN88US=>	NXXLS2RIW0GQR1XS
DMS-273	Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHfP[2JKSzVyPUCuNFM1PzlizszN	NVvZW4ZHW0GQR1XS
22RV1	NYm4fGl[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXWTWM2OD1yLkCzOVA4KM7:TR?=	MYfTRW5ITVJ?
ES8	MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3mxeGlEPTB;MD6wN\|U{QCEQvF2=	MoDHV2FPT0WU
KYSE-150	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfRTWM2OD1yLkCzOlA5KM7:TR?=	M{XtNXNCVkeHUh?=
HCC1569	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUnJR\|UxRTBwMEO2NFgh\|ryP	NV\3OWR7W0GQR1XS
NB5	M2n5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUn4[m5XUUN3ME2wMlA{PjF\|IN88US=>	MkfQV2FPT0WU
G-402	MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfKXZFKSzVyPUCuNFM3OTRizszN	NGCwW\|BUSU6JRWK=
NCI-H1693	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mm\aTWM2OD1yLkCzOlE4KM7:TR?=	NVjSdHNJW0GQR1XS
LB2241-RCC	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnm5TWM2OD1yLkCzOlQzKM7:TR?=	MnfvV2FPT0WU
KP-4	NIXL[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXLXTW1WUUN3ME2wMlA{PjZ\|IN88US=>	Mnq5V2FPT0WU
ML-2	NFjZ[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEHIfXlKSzVyPUCuNFM3PzFizszN	Mny0V2FPT0WU
KU812	NHftRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjsTWM2OD1yLkCzOlg1KM7:TR?=	NIrHZllUSU6JRWK=
LS-411N	NHjySXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;xZXBoUUN3ME2wMlA{PzNzIN88US=>	MYTTRW5ITVJ?
OAW-42	MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4HXbGlEPTB;MD6wN\|c1PyEQvF2=	MoK2V2FPT0WU
HCC38	M{nlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrp[2VKSzVyPUCuNFM4PzFizszN	MnvtV2FPT0WU
Ca-Ski	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYTqO21EUUN3ME2wMlA{Pzh2IN88US=>	M1f1dHNCVkeHUh?=
Calu-3	NImwdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvHPJVXUUN3ME2wMlA{Pzh7IN88US=>	NG[wTIhUSU6JRWK=
KYSE-70	MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTBwMEO4NVIh\|ryP	Mnr1V2FPT0WU
D-392MG	NHH3OnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIDxWIpKSzVyPUCuNFM5PDJizszN	MnrRV2FPT0WU
OVCAR-4	Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF\JOZFKSzVyPUCuNFM5PThizszN	M3TsW3NCVkeHUh?=
Detroit562	M2\UW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4[3R2lEPTB;MD6wN\|g4OiEQvF2=	MnL0V2FPT0WU
HEL	NGC3RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LVV2lEPTB;MD6wN\|g6OSEQvF2=	MVrTRW5ITVJ?
MONO-MAC-6	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1rkVWlEPTB;MD6wN\|g6OyEQvF2=	NInOW3ZUSU6JRWK=
LoVo	NVX2d\|U5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7RephKSzVyPUCuNFM6OzNizszN	NX7MXJozW0GQR1XS
U-2-OS	NFzTXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVS3[otIUUN3ME2wMlA{QTN3IN88US=>	MkfKV2FPT0WU
A172	M3z2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4[4NmlEPTB;MD6wN\|k2KM7:TR?=	MkjzV2FPT0WU
OCUB-M	M{K4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnv3TWM2OD1yLkCzPVYyKM7:TR?=	MlXLV2FPT0WU
SW48	Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3jvSGlEPTB;MD6wOFA{OSEQvF2=	M1vFOXNCVkeHUh?=
HC-1	M2LTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfoTWM2OD1yLkC0NFY6KM7:TR?=	MV;TRW5ITVJ?
KOSC-2	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV\EN5hnUUN3ME2wMlA1OTFizszN	NVvsUoFYW0GQR1XS
HDLM-2	M3TOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX\jdW0yUUN3ME2wMlA1OTF2IN88US=>	NWnOOnAxW0GQR1XS
CTV-1	NWnjNms2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYL5VlROUUN3ME2wMlA1OTF4IN88US=>	MkHuV2FPT0WU
SH-4	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUnJR\|UxRTBwMESxOFEh\|ryP	MWXTRW5ITVJ?
SW756	MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{T5TmlEPTB;MD6wOFE2PyEQvF2=	NYDWemZ{W0GQR1XS
GCT	MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHzUNHZKSzVyPUCuNFQyPjFizszN	M4\YcnNCVkeHUh?=
CHL-1	NX7jWWJZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXXJR\|UxRTBwMESxOlkh\|ryP	MWPTRW5ITVJ?
LAMA-84	NIXvcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3S3V2lEPTB;MD6wOFE4OSEQvF2=	MoTaV2FPT0WU
LS-1034	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIHWNYJKSzVyPUCuNFQyQTFizszN	MWrTRW5ITVJ?
NCI-H358	NXjodYF4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFr4bnRKSzVyPUCuNFQzOTJizszN	NIXZWHNUSU6JRWK=
NB13	MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV7lOFFHUUN3ME2wMlA1OjJ5IN88US=>	M3L0bXNCVkeHUh?=
TE-9	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEHsZoxKSzVyPUCuNFQzOzdizszN	NYPIUJdkW0GQR1XS
OE33	MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnK0TWM2OD1yLkC0NlQyKM7:TR?=	NGfp[pVUSU6JRWK=
CAL-120	NHeybZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\WTWM2OD1yLkC0NlQyKM7:TR?=	NELTS2FUSU6JRWK=
DJM-1	NUnuOpJyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkHKTWM2OD1yLkC0NlczKM7:TR?=	M4TKUnNCVkeHUh?=
SK-MEL-24	MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTwTWM2OD1yLkC0Nlg{KM7:TR?=	NUHtdmRyW0GQR1XS
VA-ES-BJ	M2\mVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETsXIVKSzVyPUCuNFQzQTJizszN	MUTTRW5ITVJ?
MMAC-SF	M4O3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;3TWM2OD1yLkC0Nlk4KM7:TR?=	NETpRlJUSU6JRWK=
MZ7-mel	MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlixTWM2OD1yLkC0N\|Mh\|ryP	MnLDV2FPT0WU
BxPC-3	NXvVTZNrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWTJR\|UxRTBwMESzOFEh\|ryP	MVfTRW5ITVJ?
HT-29	M{D0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4TsXWlEPTB;MD6wOFM2PyEQvF2=	Mn;BV2FPT0WU
SK-MEL-30	M3;hZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUDaeppVUUN3ME2wMlA1OzZ{IN88US=>	MXrTRW5ITVJ?
CAL-33	Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXPJR\|UxRTBwMESzO\|Uh\|ryP	NGTlTmlUSU6JRWK=
COLO-680N	NY[wNJpET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4XOTGlEPTB;MD6wOFQxPyEQvF2=	M{TTOnNCVkeHUh?=
NH-12	MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXf6ZY9sUUN3ME2wMlA1PDRizszN	NEDUWJVUSU6JRWK=
HCC1937	MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTBwMES0OVYh\|ryP	Mo\XV2FPT0WU
IMR-5	M1W1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fGXGlEPTB;MD6wOFQ6KM7:TR?=	MlHkV2FPT0WU
MC-CAR	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjp[Y1UUUN3ME2wMlA1PTZ7IN88US=>	NVLUdnpWW0GQR1XS
NCI-H747	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2LKTGlEPTB;MD6wOFU4KM7:TR?=	NX\3e4xGW0GQR1XS
NCI-H1792	NVrBdWROT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\GXJN2UUN3ME2wMlA1PThzIN88US=>	NX\BNYdQW0GQR1XS
SW13	Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPNUZJYUUN3ME2wMlA1PTlizszN	MkjhV2FPT0WU
MLMA	MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTBwMES2NFkh\|ryP	NFPuZ2dUSU6JRWK=
U251	MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYnOWGRDUUN3ME2wMlA1PzZ\|IN88US=>	NWfJUHpVW0GQR1XS
U031	Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nwNmlEPTB;MD6wOFc4OSEQvF2=	MVPTRW5ITVJ?
ME-180	NXLq[3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXPJR\|UxRTBwMES3PFIh\|ryP	NWnmUIV[W0GQR1XS
SK-MEL-3	NY\sVnJMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHMZoVKSzVyPUCuNFQ5ODJizszN	MojXV2FPT0WU
MOLT-4	NYjIZYlFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmLBTWM2OD1yLkC0PFA{KM7:TR?=	M1TYcHNCVkeHUh?=
PF-382	M16y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGDaVmJKSzVyPUCuNFQ5OjZizszN	NVT4WlJrW0GQR1XS
NUGC-3	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTBwMES4Nlch\|ryP	Mne5V2FPT0WU
NCI-H1417	M1i0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUXJR\|UxRTBwMES4PUDPxE1?	MYrTRW5ITVJ?
COLO-205	M{W0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3m1[WlEPTB;MD6wOFkyQSEQvF2=	MoPTV2FPT0WU
TE-441-T	NGXWd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTLTWM2OD1yLkC0PVMh\|ryP	M{\ZdHNCVkeHUh?=
MKN1	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MonkTWM2OD1yLkC0PVMh\|ryP	MYPTRW5ITVJ?
UM-UC-3	MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTBwMES5OUDPxE1?	M{\lOXNCVkeHUh?=
SF126	M4niXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFXLc5BKSzVyPUCuNFUxOSEQvF2=	NHnwOHpUSU6JRWK=
LB1047-RCC	Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1THfGlEPTB;MD6wOVA{OSEQvF2=	NV7YZZBjW0GQR1XS
A253	M{jWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXe3PG1SUUN3ME2wMlA2ODV{IN88US=>	M4riN3NCVkeHUh?=
NCI-H1963	NWf1VYRET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4HRbGlEPTB;MD6wOVE4PiEQvF2=	NFT4Z45USU6JRWK=
VM-CUB-1	NXjrdYt7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{HNbWlEPTB;MD6wOVMyOSEQvF2=	M3fUVHNCVkeHUh?=
T-24	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYO4ZZNyUUN3ME2wMlA2Ozh2IN88US=>	MUTTRW5ITVJ?
K-562	NGn4RXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYfjRWdZUUN3ME2wMlA2Ozh5IN88US=>	NGTjWnBUSU6JRWK=
ARH-77	MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYCwVZlmUUN3ME2wMlA2Ozl3IN88US=>	NHi1UmNUSU6JRWK=
CA46	MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkfXTWM2OD1yLkC1OFMh\|ryP	Ml3vV2FPT0WU
HCC70	NFLoR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTBwMEW0OVIh\|ryP	M3zp[3NCVkeHUh?=
ST486	M1PpV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTTSXR1UUN3ME2wMlA2PTJ3IN88US=>	MV;TRW5ITVJ?
COLO-741	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYe3fW83UUN3ME2wMlA2PTNzIN88US=>	NWHLdFd7W0GQR1XS
SK-PN-DW	NInDRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{TlSWlEPTB;MD6wOVU5QCEQvF2=	NGrtVFJUSU6JRWK=
BL-41	M2DJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LOSWlEPTB;MD6wOVU6PiEQvF2=	NILoXHdUSU6JRWK=
D-263MG	NEjYeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWnGeY1RUUN3ME2wMlA2Pjh\|IN88US=>	MX\TRW5ITVJ?
KE-37	MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFHFdGpKSzVyPUCuNFU3QDNizszN	NUjofmJZW0GQR1XS
LU-134-A	M1v5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXPJR\|UxRTBwMEW3NVUh\|ryP	NXHpOWNVW0GQR1XS
HCC2157	NHzab2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTBwMEW3N\|Mh\|ryP	NIDQcoVUSU6JRWK=
GAK	M37DbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvQWnlZUUN3ME2wMlA2PzN2IN88US=>	M2\HTXNCVkeHUh?=
IST-SL2	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTBwMEW3OFMh\|ryP	NFzzO4ZUSU6JRWK=
KMOE-2	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;zfWlEPTB;MD6wOVc1QSEQvF2=	Mke1V2FPT0WU
SW1573	MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTBwMEW4NFIh\|ryP	NILScYtUSU6JRWK=
SCC-9	Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TJR2lEPTB;MD6wOVg4KM7:TR?=	M3rEVHNCVkeHUh?=
MDA-MB-361	NH\IT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH:w[\|NKSzVyPUCuNFU5PzJizszN	NInSW5hUSU6JRWK=
BHT-101	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjUN2xKSzVyPUCuNFU5PzZizszN	NVrxeHRuW0GQR1XS
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OVCAR-3	NX7Xb2UxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFfPb25KSzVyPUCuNVQxPzhizszN	NFXPXYxUSU6JRWK=
NCI-H1092	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXLjcIhxUUN3ME2wMlE1OTBzIN88US=>	NXSxdoFvW0GQR1XS
HH	MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTBwMUSyNFEh\|ryP	NVjYPId[W0GQR1XS
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HD-MY-Z	NXnpdmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEP1TI1KSzVyPUCuNVQ1OjlizszN	M3zPbXNCVkeHUh?=
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U-266	Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTBwMUS0PEDPxE1?	NHTQb\|dUSU6JRWK=
GI-1	MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnW1TWM2OD1yLkG0O\|czKM7:TR?=	NWD0fmdIW0GQR1XS
NCI-H1522	NGSxXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\ZTWM2OD1yLkG0O\|g4KM7:TR?=	MnS1V2FPT0WU
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NCI-H2081	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrCNZhYUUN3ME2wMlE2OjF6IN88US=>	MnXwV2FPT0WU
THP-1	NGLBcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;pN\|VMUUN3ME2wMlE2OzN\|IN88US=>	NF;MWHBUSU6JRWK=
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RCM-1	NIXLT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnLGTWM2OD1yLkG1Olgh\|ryP	NXvpVHhKW0GQR1XS
COR-L279	NFT6RYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvnT\|ZYUUN3ME2wMlE2QDN4IN88US=>	Mnj2V2FPT0WU
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KLE	NFGzW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NU\McZozUUN3ME2wMlE3OTZ7IN88US=>	MnXXV2FPT0WU
NCI-H2170	MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXHJR\|UxRTBwMU[zNFQh\|ryP	NX7SW2tOW0GQR1XS
TGW	MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzUTWM2OD1yLkG2OFcyKM7:TR?=	M4[1UHNCVkeHUh?=
CAL-72	NWTU[lJiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3M[JE3UUN3ME2wMlE3PTlizszN	MYTTRW5ITVJ?
K052	NETOeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGroU2dKSzVyPUCuNVcxPjFizszN	MY\TRW5ITVJ?
COR-L88	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTBwMUexNVQh\|ryP	MlfiV2FPT0WU
HSC-4	M4\qemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTBwMUexOkDPxE1?	M3LsZ3NCVkeHUh?=
GOTO	NX\TbXNYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Moi1TWM2OD1yLkG3NlQ3KM7:TR?=	NGe2eo1USU6JRWK=
MEG-01	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInTcY1KSzVyPUCuNVczPTdizszN	MmfkV2FPT0WU
MDA-MB-134-VI	MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTBwMUezOlch\|ryP	Ml32V2FPT0WU
NCI-H596	NInmU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmPTTWM2OD1yLkG3N\|gh\|ryP	NGDISmNUSU6JRWK=
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NCI-H526	M1LhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHvuNlVKSzVyPUCuNVg3QTZizszN	MYrTRW5ITVJ?
MDA-MB-415	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MojMTWM2OD1yLkG5O\|Q5KM7:TR?=	MoTHV2FPT0WU
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LU-65	MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo[1TWM2OD1yLkKwNlEyKM7:TR?=	NFvUUlhUSU6JRWK=
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TGBC1TKB	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTBwMkC5PVch\|ryP	M{\vN3NCVkeHUh?=
NCI-H2196	NHLnPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmPITWM2OD1yLkKxO\|Q4KM7:TR?=	NELNNpZUSU6JRWK=
M14	NV36foZtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2PFemlEPTB;MD6yNVgxOyEQvF2=	M1rzNXNCVkeHUh?=
NCI-H1436	NETaV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVjTXnRsUUN3ME2wMlIyQDJ4IN88US=>	MkPnV2FPT0WU
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KARPAS-299	MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrDSW9VUUN3ME2wMlIzQTl2IN88US=>	NXnQR5Y6W0GQR1XS
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NCI-H838	M2e1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwMkO3NVQh\|ryP	MX7TRW5ITVJ?
NB10	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYXMXFBxUUN3ME2wMlI{PzNzIN88US=>	M1zVV3NCVkeHUh?=
NCI-H2141	M2XTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfZZpFKSzVyPUCuNlM5PDFizszN	MYLTRW5ITVJ?
LB647-SCLC	NWXMTop7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGT2eHRKSzVyPUCuNlQxOTRizszN	MmDQV2FPT0WU
NCI-H23	NVXUXWpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3TkdmlEPTB;MD6yOFA2QSEQvF2=	M{jvfnNCVkeHUh?=
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CAL-148	M{XjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NELUcmlKSzVyPUCuNlQzQDJizszN	NYHqOHhPW0GQR1XS
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MHH-NB-11	NXfZeodjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{\DbGlEPTB;MD6yOVM2KM7:TR?=	M1vyc3NCVkeHUh?=
DOK	MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXxTWM2OD1yLkK1PVMh\|ryP	MmXDV2FPT0WU
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OAW-28	M4\OOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTBwMk[2O\|ch\|ryP	MWHTRW5ITVJ?
P30-OHK	MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHDW\|dKSzVyPUCuNlY6ODVizszN	M1HLUnNCVkeHUh?=
NCI-H69	Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4GxXGlEPTB;MD6yO\|IxOSEQvF2=	Ml3LV2FPT0WU
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NCI-H1618	MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTBwMke1NUDPxE1?	MWLTRW5ITVJ?
NCI-SNU-5	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzvVo5zUUN3ME2wMlI4PjF\|IN88US=>	NV60PJhqW0GQR1XS
NCI-H1694	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWOwNYpqUUN3ME2wMlI4PzN\|IN88US=>	MX7TRW5ITVJ?
RL	MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGL5SXVKSzVyPUCuNlgyPzRizszN	M1jOZXNCVkeHUh?=
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NCI-H510A	Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwMkmzNFQh\|ryP	M2rLU3NCVkeHUh?=
Mo-T	NGTBO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYXJR\|UxRTBwMkmzN\|Eh\|ryP	NXvVbXdYW0GQR1XS
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NCI-H28	M1TYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVPDOIdWUUN3ME2wMlI6QDN5IN88US=>	NF[1bJNUSU6JRWK=
NCI-H446	M3vDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M361OWlEPTB;MD6yPVkzOSEQvF2=	NUflc25oW0GQR1XS
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MKN7	M3PrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn\0TWM2OD1yLkOwOlM6KM7:TR?=	M4T5SHNCVkeHUh?=
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MDA-MB-175-VII	NULt[\|J3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWX6[GRsUUN3ME2wMlMzOzR6IN88US=>	MkX2V2FPT0WU
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COLO-678	M2eyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmG0TWM2OD1yLkOzN\|g6KM7:TR?=	M3r5b3NCVkeHUh?=
COLO-829	MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLDTWM2OD1yLkO0OFUzKM7:TR?=	NWHlcFUzW0GQR1XS
A704	Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYTMW2s6UUN3ME2wMlM1QTJ\|IN88US=>	MmjiV2FPT0WU
NCI-H719	Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFP3XVBKSzVyPUCuN\|UyOjRizszN	MX\TRW5ITVJ?
MFE-280	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEHpVItKSzVyPUCuN\|U4OTVizszN	MmDjV2FPT0WU
DMS-114	NFraWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NInRTZpKSzVyPUCuN\|YyOiEQvF2=	MkH4V2FPT0WU
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NCI-H1882	NVf6[XEzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlHFTWM2OD1yLkSxO\|g1KM7:TR?=	NHzUcGlUSU6JRWK=
JVM-2	NYPPO49VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWD5RYxpUUN3ME2wMlQ1PDBzIN88US=>	M37wUXNCVkeHUh?=
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MHH-CALL-2	NWDhe\|ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWDJR\|UxRTBwNES4N{DPxE1?	NELsbFZUSU6JRWK=
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NEC8	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DlcGlEPTB;MD60OVE1PSEQvF2=	MYLTRW5ITVJ?
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KG-1	M163U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm\vTWM2OD1yLkW1PVg1KM7:TR?=	MoHrV2FPT0WU
C32	MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjvSZE6UUN3ME2wMlU4OzF\|IN88US=>	MYLTRW5ITVJ?
IST-SL1	MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXLvWWJrUUN3ME2wMlYxPDN3IN88US=>	NUHjRZlXW0GQR1XS
NCI-H2126	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUjE[olVUUN3ME2wMlY{OTV{IN88US=>	MkjWV2FPT0WU
HCC1954	NHXVUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrIboJ6UUN3ME2wMlY1PzJ4IN88US=>	MkTnV2FPT0WU
WM-115	M4TiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1vPS2lEPTB;MD62OVA6OiEQvF2=	M4rKN3NCVkeHUh?=
NB6	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fucWlEPTB;MD62O\|M{PSEQvF2=	NXP2W2hIW0GQR1XS
TYK-nu	MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2rwWmlEPTB;MD62O\|k2OiEQvF2=	NGjrfFZUSU6JRWK=
KY821	M2jjS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFfoV3RKSzVyPUCuO\|AzOjlizszN	NF7oW\|VUSU6JRWK=
SIMA	NFvEXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTBwN{G3NVkh\|ryP	NV;JSlJCW0GQR1XS
RCC10RGB	NYnKbWx[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWHJR\|UxRTBwN{G5NVgh\|ryP	NYGzPW1KW0GQR1XS
LN-405	NEfzPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPxTVdlUUN3ME2wMlc1OzZizszN	MV\TRW5ITVJ?
NCI-H1155	NH25dZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfuRmMzUUN3ME2wMlc1QDZ6IN88US=>	NVr5dVNPW0GQR1XS
SCLC-21H	M4TXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlTjTWM2OD1yLke2PVA{KM7:TR?=	MorWV2FPT0WU
DMS-79	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml:yTWM2OD1yLke3PFQ2KM7:TR?=	NXLTeIlsW0GQR1XS
EC-GI-10	NYruVHVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWr6RZFbUUN3ME2wMlc4QTd3IN88US=>	NYXLfo5{W0GQR1XS
KNS-42	MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1O4c2lEPTB;MD63PFg{OSEQvF2=	M{foOXNCVkeHUh?=
SNU-475	M2GxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwN{myNFIh\|ryP	NVWxVnNEW0GQR1XS
SF539	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFP3e\|hKSzVyPUCuO\|k6OjVizszN	MU\TRW5ITVJ?
SW1417	M3zoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwOEGzN\|kh\|ryP	NXnOW3VSW0GQR1XS
ATN-1	Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTBwOEWxNVUh\|ryP	NFrIWHhUSU6JRWK=
PLC-PRF-5	M1Kwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGS3NpFKSzVyPUCuPFg1PzVizszN	M4r3[HNCVkeHUh?=
HT-3	NWW1SnV3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnMPIJKSzVyPUCuPFk1OiEQvF2=	MVzTRW5ITVJ?
MDA-MB-453	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zESmlEPTB;MD65NFMxPCEQvF2=	M4fRSnNCVkeHUh?=
HAL-01	NYO3ZYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXGSpJKSzVyPUCuPVk{PzlizszN	Mn:2V2FPT0WU
NCI-H1993	NIDXWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\Lc4ZZUUN3ME2xMlA1PjV5IN88US=>	NWXVTlRVW0GQR1XS
NCI-H2227	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPsXGxKSzVyPUGuNFQ6QDFizszN	NELrTmZUSU6JRWK=
LP-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTFwME[5N{DPxE1?	NGL1XJdUSU6JRWK=
P31-FUJ	M4DZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4TtVGlEPTB;MT6xNFc3PiEQvF2=	NEjPcHlUSU6JRWK=
NCI-H64	M1;5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LhOmlEPTB;MT6xOVQzKM7:TR?=	NW\wPXRuW0GQR1XS
SW1463	NGm1WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2mwT2lEPTB;MT6xPFM1QSEQvF2=	MW\TRW5ITVJ?
SK-MEL-1	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTFwMkC1PVUh\|ryP	NFjrWWtUSU6JRWK=
TALL-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4TJUGlEPTB;MT6yOVE3PSEQvF2=	M13MVHNCVkeHUh?=
RO82-W-1	M{fzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTFwM{OzN\|kh\|ryP	MV7TRW5ITVJ?
NCI-H1581	M{T6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NITXepdKSzVyPUGuN\|U3QDdizszN	M{PVWHNCVkeHUh?=
NCI-H748	NF\kVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYjHTpRRUUN3ME2xMlM2PzN6IN88US=>	M4rQSXNCVkeHUh?=
HCC1187	NGGxc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFSyR4tKSzVyPUGuOVU2OjJizszN	NVTQeVJOW0GQR1XS
EoL-1-cell	NUPXTpZsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEi4ZnNKSzVyPUGuOVg5QDlizszN	NYjkPFM6W0GQR1XS
HuO-3N1	M{W4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4HGXWlEPTB;MT64N\|QyOiEQvF2=	NWmybGdtW0GQR1XS
NCI-H1793	MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkLhTWM2OD1zLki3OVk{KM7:TR?=	MUDTRW5ITVJ?
Caov-3	M4nkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFXQXJhKSzVyPUKuNFA3OjVizszN	NWjpeoRbW0GQR1XS
JAR	NWq5ZppCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\0dG1KSzVyPUKuNFc6OiEQvF2=	MVLTRW5ITVJ?
SK-MEL-28	Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnFV4pKSzVyPUKuNVgxQThizszN	NET0SXpUSU6JRWK=
EM-2	NHX6NJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2OwT2lEPTB;Mj6yNFI6OyEQvF2=	MUXTRW5ITVJ?
Mewo	MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYf5[446UUN3ME2yMlIzOjZ3IN88US=>	NHrZ[2VUSU6JRWK=
NCI-H720	MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWOzOpJGUUN3ME2yMlI3PTh3IN88US=>	M2X3SnNCVkeHUh?=
CAL-54	NWXETWJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjQSVZKSzVyPUKuNlY4QTVizszN	MXPTRW5ITVJ?
MC116	NYjFTlhRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTJwM{[zPVch\|ryP	MXvTRW5ITVJ?
DG-75	M2PuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MonWTWM2OD1{LkS4OVc3KM7:TR?=	NEfNV21USU6JRWK=
HCC1143	M4Pmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXm2Vm5vUUN3ME2yMlUxPjV6IN88US=>	MVLTRW5ITVJ?
FTC-133	MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTJwNUO2PFkh\|ryP	M1\HWnNCVkeHUh?=
AsPC-1	NGjROJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTJwNUO5Nlkh\|ryP	NVTVZ2NmW0GQR1XS
NCI-H889	M1vWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;F[WlEPTB;Mj61OlcxPiEQvF2=	Mle4V2FPT0WU
HT55	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYnvdmxiUUN3ME2yMlYzODF7IN88US=>	M4m3TXNCVkeHUh?=
UMC-11	NV2xZoxOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTJwN{i3NVUh\|ryP	NYXNRZhqW0GQR1XS
P12-ICHIKAWA	MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPyTHBJUUN3ME2yMlgzODR4IN88US=>	Mn3TV2FPT0WU
HCC1395	MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTJwOUi2NFIh\|ryP	NYW4WW95W0GQR1XS
D-283MED	NY[zVIpFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITpbG1KSzVyPUOuNVg6OzdizszN	MXfTRW5ITVJ?
COLO-800	MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGHhZnFKSzVyPUOuN\|M5QTdizszN	MVXTRW5ITVJ?
MFM-223	NInhW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml6yTWM2OD1\|LkO2NFk4KM7:TR?=	NUTsZYdQW0GQR1XS
TE-5	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXrdoo4UUN3ME20MlU3OTR5IN88US=>	MnX4V2FPT0WU
NCI-H209	NGS0emZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLPUZNsUUN3ME20Mlc5PTd{IN88US=>	NWTETFRpW0GQR1XS
SiHa	MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XEN2lEPTB;ND65OVIxOyEQvF2=	MVjTRW5ITVJ?
NCI-H1395	NH7JcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MliyTWM2OD13LkGwOlM{KM7:TR?=	MWLTRW5ITVJ?
A498	NUK1Nmk1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3rUN2lEPTB;NT6yNVI2OSEQvF2=	M2SyUnNCVkeHUh?=
ES5	NXvoTFhkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGK1d2JKSzVyPUWuOlEyPzhizszN	NEDG[odUSU6JRWK=
MDA-MB-157	NHLEdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmDITWM2OD13Lk[2OFQ{KM7:TR?=	MlruV2FPT0WU
NCI-H1623	NGW0ZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmKwTWM2OD13LkizOVU3KM7:TR?=	MVXTRW5ITVJ?
RPMI-8866	NVLOR5JwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlfDTWM2OD13Lki0O\|kzKM7:TR?=	MYnTRW5ITVJ?
LC-1F	M4nhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4X6SWlEPTB;Nj6wPVI6OSEQvF2=	NIHDbmFUSU6JRWK=
TCCSUP	MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnxfHpKSzVyPU[uOlA{PDlizszN	NVLqUohOW0GQR1XS
TT	NIi0NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPWTWM2OD16LkOzNFA6KM7:TR?=	NXrle2VoW0GQR1XS
NCI-H1838	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRThwNUG3N\|Eh\|ryP	M{npOXNCVkeHUh?=
NCI-H322M	Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\2foc{UUN3ME25MlE3OjhzIN88US=>	NH;xbpJUSU6JRWK=
NCI-H187	MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVW3S5V5UUN3ME25MlUyQDN3IN88US=>	NWm0TYFFW0GQR1XS
SBC-1	NYjkRnF5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVfJR\|UxRTlwOUO2OVYh\|ryP	M4fTTHNCVkeHUh?=
SCC-3	NV3YUHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTFyLkW2O\|kh\|ryP	NEDVdXVUSU6JRWK=
SW948	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LPWmlEPTB;MUCuO\|UyOSEQvF2=	MX3TRW5ITVJ?
CPC-N	NUDhb4NCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1Sxc2lEPTB;MUGuNFA4KM7:TR?=	M3nlcnNCVkeHUh?=
TGBC24TKB	MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIK2SoFKSzVyPUGzMlUzQSEQvF2=	NELaNlRUSU6JRWK=
NCI-H2452	Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2m2d2lEPTB;MUSuO\|Mh\|ryP	NXjIPZd{W0GQR1XS
Hs-578-T	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTF6LkW3OVkh\|ryP	NIL3NZBUSU6JRWK=
DV-90	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnHlTWM2OD1zOD65PVQ2KM7:TR?=	NEnFTI9USU6JRWK=
NCI-H1563	NWP2XmZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3zqT2lEPTB;MUmuO\|g5QCEQvF2=	M2S1b3NCVkeHUh?=
SW780	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVKzWWN{UUN3ME2yNU4yOzF6IN88US=>	NY\lZWd5W0GQR1XS
NCI-H345	M{XF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlrITWM2OD1{MT64O\|c6KM7:TR?=	NHnHcI1USU6JRWK=
LB771-HNC	NYHRcGtQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml7wTWM2OD1{Mj60PFE{KM7:TR?=	MY\TRW5ITVJ?
RT4	M3HPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmXsTWM2OD1{Mz6zNlgzKM7:TR?=	NWLUcFRVW0GQR1XS
NCI-H82	NX3CXZNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkHMTWM2OD1{Mz61OVI3KM7:TR?=	MVLTRW5ITVJ?
NCI-H524	MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\RPGlEPTB;MkSuN\|gyOiEQvF2=	NVfwR4VnW0GQR1XS
SNU-C1	NInWd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnLBTWM2OD1{ND65NVA2KM7:TR?=	NGO1dnBUSU6JRWK=
NCI-SNU-16	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1[0NWlEPTB;NEiuN\|E1OiEQvF2=	NYDOVFdJW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	+ Expand Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	+ Expand Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	+ Expand Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2
NCT01772797	Completed	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products4

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KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

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Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)