Luminespib (NVP-AUY922)

For research use only.

Catalog No.S1069 Synonyms: AUY-922

70 publications

Luminespib (NVP-AUY922) Chemical Structure

CAS No. 747412-49-3

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.

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Selleck's Luminespib (NVP-AUY922) has been cited by 70 publications

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Choose Selective HSP (HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK M1HJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7WcXBKSzVyPUCuNFAxOTJ3IN88US=> M3HVUXNCVkeHUh?=
MV-4-11 NUnVTpF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nKUmlEPTB;MD6wNFA2PThizszN MkfPV2FPT0WU
NALM-6 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDSdWhKSzVyPUCuNFAxQDR{IN88US=> MnTnV2FPT0WU
HOS NULRSXJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMECxN|gh|ryP NFjhT2JUSU6JRWK=
HT-144 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrMO2pEUUN3ME2wMlAxOTV3IN88US=> MYfTRW5ITVJ?
SW1710 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnHXpNnUUN3ME2wMlAxOTh4IN88US=> M3r6ZXNCVkeHUh?=
TE-8 M2[2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PHc2lEPTB;MD6wNFI{PyEQvF2= Mk\qV2FPT0WU
ES1 NH:2fZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXyyO3VXUUN3ME2wMlAxOjZ4IN88US=> M2\vZ3NCVkeHUh?=
CCF-STTG1 NVzp[HFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HXUmlEPTB;MD6wNFI6PyEQvF2= NYXyXFJiW0GQR1XS
PSN1 NEWyb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTv[pZ2UUN3ME2wMlAxOzF6IN88US=> MkHyV2FPT0WU
CAL-51 M3;aV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\UOnVKSzVyPUCuNFA{OjVizszN NFzWUmVUSU6JRWK=
MCF7 M4PxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;qTWM2OD1yLkCwN|M2KM7:TR?= NX3veoJXW0GQR1XS
SK-HEP-1 NYfnWFFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\aVGw6UUN3ME2wMlAxOzN4IN88US=> Moj1V2FPT0WU
LCLC-103H M16wbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLjTWM2OD1yLkCwOFMh|ryP MmLPV2FPT0WU
HMV-II MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLJPGVKSzVyPUCuNFA1PDlizszN MVfTRW5ITVJ?
MES-SA Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrQZnZIUUN3ME2wMlAxPDV{IN88US=> MXvTRW5ITVJ?
SK-LMS-1 MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LpVWlEPTB;MD6wNFQ2QCEQvF2= M2LMWHNCVkeHUh?=
639-V MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\JTWM2OD1yLkCwOFg2KM7:TR?= MYHTRW5ITVJ?
SIG-M5 NIn4c29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;zXVdNUUN3ME2wMlAxPDh7IN88US=> NFvlZlBUSU6JRWK=
LOUCY MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPpcYNKSzVyPUCuNFA2ODVizszN NF:1UFhUSU6JRWK=
HSC-2 NEHNOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HTPWlEPTB;MD6wNFUyQCEQvF2= M1XBXXNCVkeHUh?=
EW-13 NWLhT21lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TDTWlEPTB;MD6wNFUyQCEQvF2= MV;TRW5ITVJ?
RT-112 M{fNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rkVGlEPTB;MD6wNFU{PSEQvF2= NXXXenpEW0GQR1XS
NKM-1 M2nBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHSTWM2OD1yLkCwOVQ4KM7:TR?= MWLTRW5ITVJ?
KYSE-180 NEi5T5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXvTWM2OD1yLkCwOVg3KM7:TR?= NGjuZZhUSU6JRWK=
SW1783 M1zFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PjSWlEPTB;MD6wNFU6OSEQvF2= MYjTRW5ITVJ?
A431 M2PYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\yUWlEPTB;MD6wNFYxPyEQvF2= M1j4bXNCVkeHUh?=
SK-OV-3 NWTiToROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEC2N{DPxE1? MknFV2FPT0WU
RPMI-7951 MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L2O2lEPTB;MD6wNFY{OSEQvF2= M4LlT3NCVkeHUh?=
Capan-2 MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHtTWM2OD1yLkCwOlM5KM7:TR?= NYDKSYFGW0GQR1XS
HSC-3 M3\ydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG5TWM2OD1yLkCwOlQyKM7:TR?= NG\OWHZUSU6JRWK=
786-0 NX\nfXNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTTN2RKSzVyPUCuNFA3PjNizszN M3rN[nNCVkeHUh?=
Daoy Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3GVVBKSzVyPUCuNFA3QTVizszN NYDuU|Q1W0GQR1XS
KGN NWjDfmZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn0RlBKSzVyPUCuNFA4ODNizszN NGWyZ2NUSU6JRWK=
EW-16 NEOwSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjFPY9MUUN3ME2wMlAxPzR7IN88US=> NUTBfXRQW0GQR1XS
EW-7 M4n6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jEPWlEPTB;MD6wNFc2PCEQvF2= M4TVRnNCVkeHUh?=
IGROV-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33oPGlEPTB;MD6wNFgyPCEQvF2= MUXTRW5ITVJ?
8505C NFWzWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlexTWM2OD1yLkCwPFIyKM7:TR?= M2HLbnNCVkeHUh?=
RKO MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\BOpNKSzVyPUCuNFA5OjZizszN M33seHNCVkeHUh?=
GDM-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvFRVZmUUN3ME2wMlAxQDRizszN NGPLVJdUSU6JRWK=
IST-MEL1 M1P6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P1NWlEPTB;MD6wNFg2OiEQvF2= NEnl[|BUSU6JRWK=
RPMI-6666 NIfGemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C4NWlEPTB;MD6wNFg2OiEQvF2= M2\nO3NCVkeHUh?=
SNG-M NFnySWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEC4OVYh|ryP M3vwPHNCVkeHUh?=
KS-1 NXnHNHRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEC4OVkh|ryP NX2xdVZNW0GQR1XS
RXF393 NHriR5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTBT5JKUUN3ME2wMlAxQDZizszN NI\sPYNUSU6JRWK=
CAL-12T MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXNUJVKSzVyPUCuNFA6OjJizszN NWfZenR2W0GQR1XS
BFTC-905 NITBbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TTWM2OD1yLkCwPVM5KM7:TR?= NHv2b5ZUSU6JRWK=
SK-MES-1 NFrPSoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPhXWpKSzVyPUCuNFA6PDVizszN NWPTdVRRW0GQR1XS
BB30-HNC NE\2NZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTkTWM2OD1yLkCwPVUzKM7:TR?= M1jue3NCVkeHUh?=
AN3-CA NYDseGFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C4dmlEPTB;MD6wNVAyPyEQvF2= NGrGR2NUSU6JRWK=
EFO-27 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEGwNVch|ryP MUXTRW5ITVJ?
G-401 NVPuNY5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT0XIpbUUN3ME2wMlAyODJ3IN88US=> NHTUSGtUSU6JRWK=
BPH-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTCbXVKSzVyPUCuNFExOyEQvF2= M4f0PHNCVkeHUh?=
NCI-H727 NXXtb|ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XLOGlEPTB;MD6wNVA{KM7:TR?= MoLlV2FPT0WU
SNU-423 M1ewfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TOOmlEPTB;MD6wNVA2OyEQvF2= NIn6WVhUSU6JRWK=
KYSE-270 M2LqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7wTWM2OD1yLkCxNFU6KM7:TR?= MmHaV2FPT0WU
AGS M4LO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfRUoRKSzVyPUCuNFExPjFizszN NWezWZd{W0GQR1XS
NCI-H2228 NV;kOFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDETWM2OD1yLkCxNFY1KM7:TR?= MnjrV2FPT0WU
SW954 NYqxVGFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK3[FJKSzVyPUCuNFExPzFizszN NUTzVoFOW0GQR1XS
769-P M3fweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7xN4FKSzVyPUCuNFExPzNizszN Mm\JV2FPT0WU
BB49-HNC M1[wPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEGwO|ch|ryP M3i4c3NCVkeHUh?=
IA-LM M1XYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEGwPFYh|ryP M2[0V3NCVkeHUh?=
NB69 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXaTWM2OD1yLkCxNVAzKM7:TR?= MmP3V2FPT0WU
C8166 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD0PYoxUUN3ME2wMlAyOTJ7IN88US=> NFHWRpJUSU6JRWK=
NCI-H1299 Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETDeYFKSzVyPUCuNFEyPTRizszN MnXPV2FPT0WU
YKG-1 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P2fWlEPTB;MD6wNVE3KM7:TR?= MWLTRW5ITVJ?
PANC-03-27 M{nZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHiTWM2OD1yLkCxNVYzKM7:TR?= MlnTV2FPT0WU
YT MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjXcWQyUUN3ME2wMlAyOTd7IN88US=> Mo[xV2FPT0WU
CAL-85-1 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEGxPVIh|ryP MWLTRW5ITVJ?
GT3TKB NHGxbW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\xc|R{UUN3ME2wMlAyOjB{IN88US=> MV3TRW5ITVJ?
BB65-RCC NIHkWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHkTWM2OD1yLkCxNlA1KM7:TR?= NXnvR29FW0GQR1XS
ES6 M3;hOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jFTGlEPTB;MD6wNVI3OSEQvF2= NYDDOnVYW0GQR1XS
MHH-ES-1 NVi4[2g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEGyOlMh|ryP M1qwNXNCVkeHUh?=
QIMR-WIL MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV75UWd[UUN3ME2wMlAyOjZ7IN88US=> M{DU[HNCVkeHUh?=
SNU-C2B M{DLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37DS2lEPTB;MD6wNVI4OiEQvF2= M{jCbXNCVkeHUh?=
OCI-AML2 NGm0XmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEGyPFEh|ryP NV;CR3c5W0GQR1XS
DU-145 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEGyPUDPxE1? NEXvbHVUSU6JRWK=
SW982 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjRNVB{UUN3ME2wMlAyOjl|IN88US=> NUKwSXp6W0GQR1XS
MFH-ino M4jremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nvbGlEPTB;MD6wNVI6OyEQvF2= MXjTRW5ITVJ?
A427 NV;lTHlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEGyPVkh|ryP MUjTRW5ITVJ?
LCLC-97TM1 NWf4WYJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTSXZhSUUN3ME2wMlAyOyEQvF2= NV;yPHJLW0GQR1XS
AM-38 NUXxc3FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHWTVlKSzVyPUCuNFE{ODJizszN M4HsdHNCVkeHUh?=
K5 NXzjcpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfqO3NKSzVyPUCuNFE{ODhizszN M3zDT3NCVkeHUh?=
T84 NVLlN41kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPGTWM2OD1yLkCxN|MyKM7:TR?= MWPTRW5ITVJ?
TE-15 NHfPd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYqwboJSUUN3ME2wMlAyOzN4IN88US=> MUfTRW5ITVJ?
NCI-H460 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y2b2lEPTB;MD6wNVM{PiEQvF2= M3roZnNCVkeHUh?=
NTERA-S-cl-D1 M{TT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XFTWlEPTB;MD6wNVM{QSEQvF2= MorHV2FPT0WU
KYSE-450 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nheGlEPTB;MD6wNVM1QSEQvF2= MlXPV2FPT0WU
H4 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LLOmlEPTB;MD6wNVM3PiEQvF2= NF7zc29USU6JRWK=
LC-2-ad NUTV[nN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HXVGlEPTB;MD6wNVM4KM7:TR?= M2TlXHNCVkeHUh?=
GAMG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvtTWM2OD1yLkCxN|cyKM7:TR?= NYjzXW5OW0GQR1XS
TK10 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHZUXpKSzVyPUCuNFE{QDJizszN NULJd45yW0GQR1XS
NCI-H2122 NHfHZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;IV2lEPTB;MD6wNVM5PCEQvF2= Mmm2V2FPT0WU
KM12 NGXEOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3VTWM2OD1yLkCxN|k6KM7:TR?= MnH2V2FPT0WU
CAL-39 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEG0NkDPxE1? NVOxfFZQW0GQR1XS
RPMI-2650 M{[wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XXeWlEPTB;MD6wNVQ{OiEQvF2= MWDTRW5ITVJ?
KYSE-510 NFO3dZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfDTWM2OD1yLkCxOFQzKM7:TR?= MXLTRW5ITVJ?
KALS-1 NXrBZoRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe1bYl{UUN3ME2wMlAyPDZ4IN88US=> NY\6XVZEW0GQR1XS
NCI-H1648 M1XLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDVpNKSzVyPUCuNFE1QTlizszN MlH5V2FPT0WU
ES4 NXzTfXZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T5RWlEPTB;MD6wNVUxOiEQvF2= NVTEUndNW0GQR1XS
C-33-A M1vVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ftOmlEPTB;MD6wNVUxQSEQvF2= NViyeWRCW0GQR1XS
MIA-PaCa-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HhZmlEPTB;MD6wNVUxQSEQvF2= NIXsZ|ZUSU6JRWK=
Becker NGPZepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3TcFhKSzVyPUCuNFE2OTRizszN MnfGV2FPT0WU
HOP-62 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m5[mlEPTB;MD6wNVU1OiEQvF2= NF;xRWtUSU6JRWK=
TE-1 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GxTWlEPTB;MD6wNVU5OSEQvF2= M1jiVXNCVkeHUh?=
KYSE-410 M1KyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDiTWM2OD1yLkCxOVg3KM7:TR?= M{nhbXNCVkeHUh?=
NOS-1 M3\Sb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HSN2lEPTB;MD6wNVU6OyEQvF2= MYLTRW5ITVJ?
MEL-HO NVfhbGVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qwPGlEPTB;MD6wNVY1OyEQvF2= MkX0V2FPT0WU
NCI-H1650 M2rSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HmbWlEPTB;MD6wNVY1PiEQvF2= NXfSWXBrW0GQR1XS
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HuP-T3 NGTtR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEG2OVMh|ryP MVfTRW5ITVJ?
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OVCAR-8 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\zV2lOUUN3ME2wMlA{OjhzIN88US=> M1L0O3NCVkeHUh?=
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BC-1 NUPldHhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[yNWlEPTB;MD6wN|M3PyEQvF2= MVvTRW5ITVJ?
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RS4-11 M{TUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEOzPFMh|ryP NFnJWZhUSU6JRWK=
JiyoyeP-2003 M{jLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni4TWM2OD1yLkCzN|g5KM7:TR?= MX7TRW5ITVJ?
BL-70 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLlTWM2OD1yLkCzN|g6KM7:TR?= MmS1V2FPT0WU
OS-RC-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEOzPVYh|ryP NHfZfWlUSU6JRWK=
SF268 NYT4U2l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLXTWM2OD1yLkCzOFAyKM7:TR?= M3PGXnNCVkeHUh?=
BV-173 M{nQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PGUGlEPTB;MD6wN|QzPiEQvF2= MYrTRW5ITVJ?
DMS-273 M1PKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rV[2lEPTB;MD6wN|Q4QSEQvF2= NUHkfI44W0GQR1XS
22RV1 NUDyeXd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEO1NFch|ryP NIDHZVdUSU6JRWK=
ES8 NFTaWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEO1N|gh|ryP NFr4NoRUSU6JRWK=
KYSE-150 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEO2NFgh|ryP NHj2c|hUSU6JRWK=
HCC1569 NEDTWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPlTI5WUUN3ME2wMlA{PjB6IN88US=> MVLTRW5ITVJ?
NB5 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj3TWM2OD1yLkCzOlE{KM7:TR?= NIOw[IVUSU6JRWK=
G-402 NXLBZphMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M375cWlEPTB;MD6wN|YyPCEQvF2= MVrTRW5ITVJ?
NCI-H1693 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fDZWlEPTB;MD6wN|YyPyEQvF2= Mke4V2FPT0WU
LB2241-RCC NIftU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1yLkCzOlQzKM7:TR?= MlnGV2FPT0WU
KP-4 NWPyNWRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7yTWM2OD1yLkCzOlY{KM7:TR?= M4\R[HNCVkeHUh?=
ML-2 M{nIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzVUXJKSzVyPUCuNFM3PzFizszN NWnCUXZ5W0GQR1XS
KU812 NGHuZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PvcmlEPTB;MD6wN|Y5PCEQvF2= NGH4dJVUSU6JRWK=
LS-411N MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTG[Gk2UUN3ME2wMlA{PzNzIN88US=> NHXHTVdUSU6JRWK=
OAW-42 NHLVfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEO3OFch|ryP MWrTRW5ITVJ?
HCC38 MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C0TGlEPTB;MD6wN|c4OSEQvF2= NIHjdpVUSU6JRWK=
Ca-Ski NXOyeGRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4SGxyUUN3ME2wMlA{Pzh2IN88US=> MVvTRW5ITVJ?
Calu-3 M4Lp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILOPVBKSzVyPUCuNFM4QDlizszN NIjDPWtUSU6JRWK=
KYSE-70 NFj3e2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEO4NVIh|ryP MUHTRW5ITVJ?
D-392MG NXXDPVQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEO4OFIh|ryP M2HiZ3NCVkeHUh?=
OVCAR-4 NX\UNo1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{iwNmlEPTB;MD6wN|g2QCEQvF2= MV;TRW5ITVJ?
Detroit562 NHzWWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n6TGlEPTB;MD6wN|g4OiEQvF2= MojxV2FPT0WU
HEL MoeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfLcYZKSzVyPUCuNFM5QTFizszN NX7kUYVPW0GQR1XS
MONO-MAC-6 M1TV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnuWVJ[UUN3ME2wMlA{QDl|IN88US=> NGTZRVlUSU6JRWK=
LoVo MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDE[GJTUUN3ME2wMlA{QTN|IN88US=> MVXTRW5ITVJ?
U-2-OS M37oWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzHTWM2OD1yLkCzPVM2KM7:TR?= NYP4T4FsW0GQR1XS
A172 Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEO5OUDPxE1? NYfDOYluW0GQR1XS
OCUB-M MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrDO|hKSzVyPUCuNFM6PjFizszN Mle1V2FPT0WU
SW48 M3LMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL1TWM2OD1yLkC0NFMyKM7:TR?= M1HWXnNCVkeHUh?=
HC-1 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\zd2lEPTB;MD6wOFA3QSEQvF2= MVXTRW5ITVJ?
KOSC-2 NWPaZo9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK5TWM2OD1yLkC0NVEh|ryP MkDMV2FPT0WU
HDLM-2 NFfqOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMESxNVQh|ryP MknGV2FPT0WU
CTV-1 MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjBZmhjUUN3ME2wMlA1OTF4IN88US=> M3vDOXNCVkeHUh?=
SH-4 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGyTWM2OD1yLkC0NVQyKM7:TR?= NUnYOVk5W0GQR1XS
SW756 NHPlTlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXft[24zUUN3ME2wMlA1OTV5IN88US=> NYrQeHdzW0GQR1XS
GCT MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\tRWpKSzVyPUCuNFQyPjFizszN MmjZV2FPT0WU
CHL-1 NYrEW5NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf4TFZMUUN3ME2wMlA1OTZ7IN88US=> NET4d45USU6JRWK=
LAMA-84 NF3R[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMESxO|Eh|ryP MYnTRW5ITVJ?
LS-1034 NF:4NmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XMPWlEPTB;MD6wOFE6OSEQvF2= MXjTRW5ITVJ?
NCI-H358 NV3uR3RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;xOWlEPTB;MD6wOFIyOiEQvF2= M4HOTHNCVkeHUh?=
NB13 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD1yLkC0NlI4KM7:TR?= MWrTRW5ITVJ?
TE-9 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;5cGtKSzVyPUCuNFQzOzdizszN MV3TRW5ITVJ?
OE33 M4G3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnrdFdlUUN3ME2wMlA1OjRzIN88US=> M3;ESXNCVkeHUh?=
CAL-120 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnmTWM2OD1yLkC0NlQyKM7:TR?= NUnhVoZ3W0GQR1XS
DJM-1 NF:4UG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrKe5RQUUN3ME2wMlA1Ojd{IN88US=> NVfjOZBiW0GQR1XS
SK-MEL-24 NWTVWZRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPzXlZKSzVyPUCuNFQzQDNizszN MYTTRW5ITVJ?
VA-ES-BJ M4KxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\OPXdQUUN3ME2wMlA1Ojl{IN88US=> MWXTRW5ITVJ?
MMAC-SF M{P3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTUTWM2OD1yLkC0Nlk4KM7:TR?= MonrV2FPT0WU
MZ7-mel NYXU[3pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XTNWlEPTB;MD6wOFM{KM7:TR?= NV7FT|RjW0GQR1XS
BxPC-3 M1TUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vlV2lEPTB;MD6wOFM1OSEQvF2= NFfPd29USU6JRWK=
HT-29 M4ryNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMESzOVch|ryP NXiwTXFOW0GQR1XS
SK-MEL-30 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTeoh[UUN3ME2wMlA1OzZ{IN88US=> NXjzWFE2W0GQR1XS
CAL-33 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPiToNKSzVyPUCuNFQ{PzVizszN NHzOc|ZUSU6JRWK=
COLO-680N NGDjcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi5dpFKSzVyPUCuNFQ1ODdizszN MnnaV2FPT0WU
NH-12 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMES0OEDPxE1? NFjxWY9USU6JRWK=
HCC1937 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GyWmlEPTB;MD6wOFQ2PiEQvF2= M3qzbHNCVkeHUh?=
IMR-5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XMfmlEPTB;MD6wOFQ6KM7:TR?= MmfQV2FPT0WU
MC-CAR M4nVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\XTWM2OD1yLkC0OVY6KM7:TR?= NW\a[FFXW0GQR1XS
NCI-H747 NHnRZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3lfXZvUUN3ME2wMlA1PTdizszN M2rxPHNCVkeHUh?=
NCI-H1792 NH;rbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMES1PFEh|ryP MknzV2FPT0WU
SW13 M3rKdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HWd2lEPTB;MD6wOFU6KM7:TR?= NHHLflRUSU6JRWK=
MLMA NWnTcVBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XZU2lEPTB;MD6wOFYxQSEQvF2= MYXTRW5ITVJ?
U251 NWfORnd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLFZYVKSzVyPUCuNFQ4PjNizszN MnKxV2FPT0WU
U031 M3;mSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMES3O|Eh|ryP NV;3WIljW0GQR1XS
ME-180 NWnMNVZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMES3PFIh|ryP MoDwV2FPT0WU
SK-MEL-3 NIn5XHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\VcWtKSzVyPUCuNFQ5ODJizszN NF7Zd|ZUSU6JRWK=
MOLT-4 NFLCWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4RohYUUN3ME2wMlA1QDB|IN88US=> NFTGXXhUSU6JRWK=
PF-382 NHPYTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nv[WlEPTB;MD6wOFgzPiEQvF2= NIfPb4ZUSU6JRWK=
NUGC-3 M4Kzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2GxeWlEPTB;MD6wOFgzPyEQvF2= NEO2RYRUSU6JRWK=
NCI-H1417 NFm1Z|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzoTWM2OD1yLkC0PFkh|ryP NF7vbGNUSU6JRWK=
COLO-205 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2xc|dEUUN3ME2wMlA1QTF7IN88US=> Mli2V2FPT0WU
TE-441-T MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXlRnlKSzVyPUCuNFQ6OyEQvF2= NIe4U4xUSU6JRWK=
MKN1 M3;YbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMES5N{DPxE1? M3nMPHNCVkeHUh?=
UM-UC-3 NWfVfHRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f6PGlEPTB;MD6wOFk2KM7:TR?= NFG4XpNUSU6JRWK=
SF126 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PJeWlEPTB;MD6wOVAyKM7:TR?= NWfXW2JvW0GQR1XS
LB1047-RCC MkHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvnTWM2OD1yLkC1NFMyKM7:TR?= M3TQO3NCVkeHUh?=
A253 M17yeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG4PHZwUUN3ME2wMlA2ODV{IN88US=> NETucVhUSU6JRWK=
NCI-H1963 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTSTWM2OD1yLkC1NVc3KM7:TR?= MUjTRW5ITVJ?
VM-CUB-1 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLKTWM2OD1yLkC1N|EyKM7:TR?= M3\MeHNCVkeHUh?=
T-24 NYW1XXkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvZTWM2OD1yLkC1N|g1KM7:TR?= MX3TRW5ITVJ?
K-562 MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyOGlEPTB;MD6wOVM5PyEQvF2= NUjUU4h[W0GQR1XS
ARH-77 NGTIU5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEWzPVUh|ryP M1f5W3NCVkeHUh?=
CA46 NX\FfJBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq5TWM2OD1yLkC1OFMh|ryP NYXKNplXW0GQR1XS
HCC70 MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\iTWM2OD1yLkC1OFUzKM7:TR?= NVzQNYZkW0GQR1XS
ST486 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XKTmlEPTB;MD6wOVUzPSEQvF2= NGfW[nRUSU6JRWK=
COLO-741 M1XsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzCTWM2OD1yLkC1OVMyKM7:TR?= M1:zN3NCVkeHUh?=
SK-PN-DW NGfxXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEW1PFgh|ryP NX7iVnlvW0GQR1XS
BL-41 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPzbINVUUN3ME2wMlA2PTl4IN88US=> MmXOV2FPT0WU
D-263MG NEjJOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEW2PFMh|ryP NYftWZo3W0GQR1XS
KE-37 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK1TWM2OD1yLkC1Olg{KM7:TR?= NH7sZ|RUSU6JRWK=
LU-134-A NUL4WJpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEW3NVUh|ryP M2f0eHNCVkeHUh?=
HCC2157 NUfsN|dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvpNnIzUUN3ME2wMlA2PzN|IN88US=> M3exOHNCVkeHUh?=
GAK NFLLWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEW3N|Qh|ryP NYnwbZByW0GQR1XS
IST-SL2 Mm\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHRTWM2OD1yLkC1O|Q{KM7:TR?= NGX1cHZUSU6JRWK=
KMOE-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv6RlZKSzVyPUCuNFU4PDlizszN NUL5[|YzW0GQR1XS
SW1573 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Pjd2lEPTB;MD6wOVgxOiEQvF2= MUHTRW5ITVJ?
SCC-9 NFHzT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDtdYVKSzVyPUCuNFU5PyEQvF2= NUDudWFbW0GQR1XS
MDA-MB-361 NX3uOIEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LmPGlEPTB;MD6wOVg4OiEQvF2= MlvnV2FPT0WU
BHT-101 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrOdW91UUN3ME2wMlA2QDd4IN88US=> M{n0SnNCVkeHUh?=
NCI-H1770 NEXze4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK1TGVKSzVyPUCuNFU5PzlizszN NGG0RlJUSU6JRWK=
UACC-893 NGP4fXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\IW2lEPTB;MD6wOVg6PiEQvF2= NVzSTIlSW0GQR1XS
NCI-H226 NXGxUmtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T2SmlEPTB;MD6wOVk5QCEQvF2= NY\0d4Z4W0GQR1XS
HLE NHTsW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXHTWM2OD1yLkC2NFgzKM7:TR?= NFPj[mJUSU6JRWK=
NCI-H1703 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS3WVRWUUN3ME2wMlA3OTd6IN88US=> NWTsWVV7W0GQR1XS
KURAMOCHI NIDrVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K3UGlEPTB;MD6wOlE5QSEQvF2= MUfTRW5ITVJ?
RH-1 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKW2lEPTB;MD6wOlI{KM7:TR?= NXvCdWUyW0GQR1XS
DSH1 NID5[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj4UoVKSzVyPUCuNFYzPyEQvF2= MkDsV2FPT0WU
CAMA-1 NHPxNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwME[zNFMh|ryP NW\Ie3Q6W0GQR1XS
NCI-H1437 NVHSW2F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonQTWM2OD1yLkC2N|I5KM7:TR?= NGG0eoJUSU6JRWK=
HuP-T4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Hs[mlEPTB;MD6wOlU5PiEQvF2= M3fQV3NCVkeHUh?=
HCT-15 M2DzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwME[1PVch|ryP NX\RUGpLW0GQR1XS
NCCIT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoO3TWM2OD1yLkC2OlA1KM7:TR?= NV;uS3d[W0GQR1XS
BOKU M{D0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXY[JhHUUN3ME2wMlA3Pjd2IN88US=> MUfTRW5ITVJ?
FADU MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwME[3OFUh|ryP MULTRW5ITVJ?
SUP-T1 M{j3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTGTWM2OD1yLkC2O|Yh|ryP NFvIcGRUSU6JRWK=
L-363 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwME[5NFEh|ryP MoLlV2FPT0WU
KNS-81-FD NFzJZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfhTWM2OD1yLkC2PVE5KM7:TR?= MULTRW5ITVJ?
SU-DHL-1 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P5RWlEPTB;MD6wOlkzKM7:TR?= MUPTRW5ITVJ?
HuH-7 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTOVWtKSzVyPUCuNFcxOzVizszN Ml\aV2FPT0WU
BT-474 NILhToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC4TWM2OD1yLkC3NFYyKM7:TR?= NX23[HlFW0GQR1XS
CAPAN-1 NVHue3plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDFUVFKSzVyPUCuNFcyPDNizszN MnfNV2FPT0WU
HEC-1 M33oT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WxOGlEPTB;MD6wO|E3OSEQvF2= MlXUV2FPT0WU
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RO82-W-1 NITMdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7NTWM2OD1zLkOzN|M6KM7:TR?= M2TCcHNCVkeHUh?=
NCI-H1581 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnOXYVKSzVyPUGuN|U3QDdizszN MkC4V2FPT0WU
NCI-H748 NYTx[3hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjKbmtKSzVyPUGuN|U4OzhizszN MWTTRW5ITVJ?
HCC1187 NILPVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjySo9LUUN3ME2xMlU2PTJ{IN88US=> NYntblI3W0GQR1XS
EoL-1-cell M2XJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TDUWlEPTB;MT61PFg5QSEQvF2= NXP6S4U3W0GQR1XS
HuO-3N1 NUHYPJhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPhTGp2UUN3ME2xMlg{PDF{IN88US=> M2rybXNCVkeHUh?=
NCI-H1793 M3zqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTubFFzUUN3ME2xMlg4PTl|IN88US=> MUjTRW5ITVJ?
Caov-3 NFfTeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjvTWM2OD1{LkCwOlI2KM7:TR?= MWHTRW5ITVJ?
JAR NFzvc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPlTWM2OD1{LkC3PVIh|ryP M3HJTnNCVkeHUh?=
SK-MEL-28 NVHCfpdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwMUiwPVgh|ryP MVHTRW5ITVJ?
EM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW5TWM2OD1{LkKwNlk{KM7:TR?= MlTMV2FPT0WU
Mewo NXzHSpRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;odWlEPTB;Mj6yNlI3PSEQvF2= MUjTRW5ITVJ?
NCI-H720 NVnTOXA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYWyOG1yUUN3ME2yMlI3PTh3IN88US=> MXXTRW5ITVJ?
CAL-54 M4K5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q2UmlEPTB;Mj6yOlc6PSEQvF2= MV;TRW5ITVJ?
MC116 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTUTWM2OD1{LkO2N|k4KM7:TR?= NGfZUpNUSU6JRWK=
DG-75 MorFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwNEi1O|Yh|ryP Mkf1V2FPT0WU
HCC1143 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnNTWM2OD1{LkWwOlU5KM7:TR?= MY\TRW5ITVJ?
FTC-133 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnEXmFKSzVyPUKuOVM3QDlizszN NF\reJNUSU6JRWK=
AsPC-1 M2rIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:zTWM2OD1{LkWzPVI6KM7:TR?= MWHTRW5ITVJ?
NCI-H889 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf4bWhKSzVyPUKuOVY4ODZizszN NYPMTFR{W0GQR1XS
HT55 NHrXNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL3dpBKSzVyPUKuOlIxOTlizszN NWqwVJB{W0GQR1XS
UMC-11 NWjGUoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHFWHE3UUN3ME2yMlc5PzF3IN88US=> M4nIZnNCVkeHUh?=
P12-ICHIKAWA MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJwOEKwOFYh|ryP NGXWdG9USU6JRWK=
HCC1395 NXO5eYtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MleyTWM2OD1{Lkm4OlAzKM7:TR?= NGHwfXZUSU6JRWK=
D-283MED M2rHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPzOmxKSzVyPUOuNVg6OzdizszN MXTTRW5ITVJ?
COLO-800 NVvnU5c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3XPXZKSzVyPUOuN|M5QTdizszN NFzxW49USU6JRWK=
MFM-223 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HyemlEPTB;Mz6zOlA6PyEQvF2= NVPKXZZGW0GQR1XS
TE-5 NF61TWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTRwNU[xOFch|ryP NFnQ[phUSU6JRWK=
NCI-H209 NI\ocXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf5bG5KSzVyPUSuO|g2PzJizszN MnmzV2FPT0WU
SiHa NX;Sd5BtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjHNGtKSzVyPUSuPVUzODNizszN NE\KbnRUSU6JRWK=
NCI-H1395 M1TWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTVwMUC2N|Mh|ryP NXK4V5J{W0GQR1XS
A498 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXvTWM2OD13LkKxNlUyKM7:TR?= NHq1OnRUSU6JRWK=
ES5 NYS3PYw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnldGRKSzVyPUWuOlEyPzhizszN MlnGV2FPT0WU
MDA-MB-157 NGWySJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe2V|dyUUN3ME21MlY3PDR|IN88US=> Mm\MV2FPT0WU
NCI-H1623 NHvrRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH5VWhKSzVyPUWuPFM2PTZizszN NF63fo1USU6JRWK=
RPMI-8866 NG\3NXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvBTWM2OD13Lki0O|kzKM7:TR?= MVnTRW5ITVJ?
LC-1F MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XjZWlEPTB;Nj6wPVI6OSEQvF2= NVXCcGl5W0GQR1XS
TCCSUP NGXSdoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jM[GlEPTB;Nj62NFM1QSEQvF2= NYrpeY1mW0GQR1XS
TT MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli4TWM2OD16LkOzNFA6KM7:TR?= MYjTRW5ITVJ?
NCI-H1838 NWn1eGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7xXWF{UUN3ME24MlUyPzNzIN88US=> M3PvcHNCVkeHUh?=
NCI-H322M M4i0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr4SFU1UUN3ME25MlE3OjhzIN88US=> NVT2[Y54W0GQR1XS
NCI-H187 NYXmSXA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvSNHlyUUN3ME25MlUyQDN3IN88US=> Mmn6V2FPT0WU
SBC-1 M{jNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfPcHlkUUN3ME25Mlk{PjV4IN88US=> MY\TRW5ITVJ?
SCC-3 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPFXJBKSzVyPUGwMlU3PzlizszN NUTtSHQyW0GQR1XS
SW948 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjHTWM2OD1zMD63OVEyKM7:TR?= NWLVSXhPW0GQR1XS
CPC-N MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIiySVZKSzVyPUGxMlAxPyEQvF2= NX\5O2tXW0GQR1XS
TGBC24TKB M4[0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTNbopCUUN3ME2xN{42OjlizszN NWf6cIZQW0GQR1XS
NCI-H2452 NEfsepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF2LkezJO69VQ>? MVLTRW5ITVJ?
Hs-578-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XmcGlEPTB;MUiuOVc2QSEQvF2= M1;i[3NCVkeHUh?=
DV-90 NWjKNXhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITQUVdKSzVyPUG4Mlk6PDVizszN NUO1fnFHW0GQR1XS
NCI-H1563 NFHiTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF7Lke4PFgh|ryP M3;0OnNCVkeHUh?=
SW780 M1qxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJzLkGzNVgh|ryP MUXTRW5ITVJ?
NCI-H345 M2L6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknlTWM2OD1{MT64O|c6KM7:TR?= NUXSdmdVW0GQR1XS
LB771-HNC NFzKOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG2TWM2OD1{Mj60PFE{KM7:TR?= MUXTRW5ITVJ?
RT4 NHricGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ|LkOyPFIh|ryP Mn;ZV2FPT0WU
NCI-H82 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPRVYpwUUN3ME2yN{42PTJ4IN88US=> MV3TRW5ITVJ?
NCI-H524 Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJ2LkO4NVIh|ryP MX;TRW5ITVJ?
SNU-C1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv3d41tUUN3ME2yOE46OTB3IN88US=> NI\ocWZUSU6JRWK=
NCI-SNU-16 NVj4Nm9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37Nd2lEPTB;NEiuN|E1OiEQvF2= M2mw[nNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; 

PubMed: 23993685     


Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein.

E-cadherin / Cleaved PARP / Bim; 

PubMed: 23993685     


Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein.

HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; 

PubMed: 24796583     


CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control.

CDK4 / HMGA2 ; 

PubMed: 26893968     


HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.

23993685 24796583 26893968
Growth inhibition assay
Cell viability; 

PubMed: 26893968     


Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed in three independent experiments.

26893968
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
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Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
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  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Water Insoluble
Ethanol ''31 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms AUY-922
Smiles CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Drug: AUY922 Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Drug: AUY922|Drug: BYL719 Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1
NCT01484860 Terminated Drug: AUY922 Adenocarcinoma of the Pancreas|Metastatic Disease University Health Network Toronto|Novartis Pharmaceuticals January 2012 Phase 2
NCT01402401 Terminated Drug: AUY922 + Trastuzumab Advanced Gastric Cancer Novartis Pharmaceuticals|Novartis November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID