Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NXr0VW9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PmU2lEPTB;MD6wNFAyOjVizszN M4m2dnNCVkeHUh?=
MV-4-11 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjtNHlKSzVyPUCuNFAxPTV6IN88US=> MoXrV2FPT0WU
NALM-6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTjTWM2OD1yLkCwNFg1OiEQvF2= NGOz[IlUSU6JRWK=
HOS Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2ZZg2UUN3ME2wMlAxOTN6IN88US=> M1PLUXNCVkeHUh?=
HT-144 M2jWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjx[mx3UUN3ME2wMlAxOTV3IN88US=> MkPwV2FPT0WU
SW1710 NVXlbGxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTHTWM2OD1yLkCwNVg3KM7:TR?= MW\TRW5ITVJ?
TE-8 MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfWclFRUUN3ME2wMlAxOjN5IN88US=> NH\FXGxUSU6JRWK=
ES1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn1TWM2OD1yLkCwNlY3KM7:TR?= MYjTRW5ITVJ?
CCF-STTG1 NGTZ[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vKU2lEPTB;MD6wNFI6PyEQvF2= MoKyV2FPT0WU
PSN1 M2rSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5U3VtUUN3ME2wMlAxOzF6IN88US=> MVnTRW5ITVJ?
CAL-51 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XnW2lEPTB;MD6wNFMzPSEQvF2= NYfEXFh6W0GQR1XS
MCF7 M2K1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfPW3hKSzVyPUCuNFA{OzVizszN Mn7MV2FPT0WU
SK-HEP-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECzN|Yh|ryP NEDaeY5USU6JRWK=
LCLC-103H M{TXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXVSmdYUUN3ME2wMlAxPDNizszN NI[yWHVUSU6JRWK=
HMV-II NGrtfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILYPJhKSzVyPUCuNFA1PDlizszN Mn\BV2FPT0WU
MES-SA M{j1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEC0OVIh|ryP NVO2e|dHW0GQR1XS
SK-LMS-1 M{\qRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7SUmJrUUN3ME2wMlAxPDV6IN88US=> MmK3V2FPT0WU
639-V MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXTWM2OD1yLkCwOFg2KM7:TR?= M1ruTnNCVkeHUh?=
SIG-M5 M3LOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17UV2lEPTB;MD6wNFQ5QSEQvF2= NXjPNYpHW0GQR1XS
LOUCY NULMWJdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DSUGlEPTB;MD6wNFUxPSEQvF2= NGC1U2FUSU6JRWK=
HSC-2 NHLMPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3TeVdKSzVyPUCuNFA2OThizszN M{S5XXNCVkeHUh?=
EW-13 NEfEZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T6OGlEPTB;MD6wNFUyQCEQvF2= NGXldlBUSU6JRWK=
RT-112 NXzKfIR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:zXJRKSzVyPUCuNFA2OzVizszN NF\xU4VUSU6JRWK=
NKM-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK4bXdKSzVyPUCuNFA2PDdizszN M2\ubnNCVkeHUh?=
KYSE-180 M4P2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pTWM2OD1yLkCwOVg3KM7:TR?= NYrYS5lnW0GQR1XS
SW1783 NFHubHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEC1PVEh|ryP M4L1XHNCVkeHUh?=
A431 M2r1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDVnBKSzVyPUCuNFA3ODdizszN M1K3SHNCVkeHUh?=
SK-OV-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nodGlEPTB;MD6wNFY{KM7:TR?= M{fqV3NCVkeHUh?=
RPMI-7951 MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DJNGlEPTB;MD6wNFY{OSEQvF2= NHLYRnVUSU6JRWK=
Capan-2 NH3PeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nrdWlEPTB;MD6wNFY{QCEQvF2= NIr2UpJUSU6JRWK=
HSC-3 NVO3SGd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS0TWM2OD1yLkCwOlQyKM7:TR?= MX\TRW5ITVJ?
786-0 M4L6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PFV2lEPTB;MD6wNFY3OyEQvF2= MULTRW5ITVJ?
Daoy MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLkTWM2OD1yLkCwOlk2KM7:TR?= MnXEV2FPT0WU
KGN MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HZdGlEPTB;MD6wNFcxOyEQvF2= NXy4R2NsW0GQR1XS
EW-16 NFHBZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvyTWM2OD1yLkCwO|Q6KM7:TR?= MVrTRW5ITVJ?
EW-7 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEC3OVQh|ryP NUjYTHZQW0GQR1XS
IGROV-1 NXvpPHdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLjTWM2OD1yLkCwPFE1KM7:TR?= NXXDeGF[W0GQR1XS
8505C MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PhXWlEPTB;MD6wNFgzOSEQvF2= M3fnWHNCVkeHUh?=
RKO M1v6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLyUGxKSzVyPUCuNFA5OjZizszN NX3TfWxXW0GQR1XS
GDM-1 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2G4fGlEPTB;MD6wNFg1KM7:TR?= NF74SlhUSU6JRWK=
IST-MEL1 M2\1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;mcYZmUUN3ME2wMlAxQDV{IN88US=> NFzxeGdUSU6JRWK=
RPMI-6666 NHvSVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrOmlEPTB;MD6wNFg2OiEQvF2= M4jFXHNCVkeHUh?=
SNG-M NXrB[ppPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n5cGlEPTB;MD6wNFg2PiEQvF2= MnrLV2FPT0WU
KS-1 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW3OXI2UUN3ME2wMlAxQDV7IN88US=> MkTFV2FPT0WU
RXF393 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\BTGlEPTB;MD6wNFg3KM7:TR?= NVjvWoxFW0GQR1XS
CAL-12T NH;lO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLmTWM2OD1yLkCwPVIzKM7:TR?= M1;2fnNCVkeHUh?=
BFTC-905 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDTTWM2OD1yLkCwPVM5KM7:TR?= M3vjZXNCVkeHUh?=
SK-MES-1 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEC5OFUh|ryP M1vtfHNCVkeHUh?=
BB30-HNC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnBblk2UUN3ME2wMlAxQTV{IN88US=> NF\URZFUSU6JRWK=
AN3-CA NH64OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnoXIpTUUN3ME2wMlAyODF5IN88US=> M3y5fHNCVkeHUh?=
EFO-27 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;2OHQ6UUN3ME2wMlAyODF5IN88US=> MVfTRW5ITVJ?
G-401 M1rOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HCbWlEPTB;MD6wNVAzPSEQvF2= MonDV2FPT0WU
BPH-1 NHy5WHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEGwN{DPxE1? NUTQV5NMW0GQR1XS
NCI-H727 NWO0boE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofRTWM2OD1yLkCxNFMh|ryP NXLVXm15W0GQR1XS
SNU-423 NXTxR|ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzZ2lEPTB;MD6wNVA2OyEQvF2= NXXiPZVbW0GQR1XS
KYSE-270 M37u[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTvTWM2OD1yLkCxNFU6KM7:TR?= MoCxV2FPT0WU
AGS MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jCNWlEPTB;MD6wNVA3OSEQvF2= NXzwOHZjW0GQR1XS
NCI-H2228 M3W5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEGwOlQh|ryP MmjiV2FPT0WU
SW954 NXfyN3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zRWGlEPTB;MD6wNVA4OSEQvF2= MlrUV2FPT0WU
769-P NFrpTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjqeVN2UUN3ME2wMlAyODd|IN88US=> M4XxUHNCVkeHUh?=
BB49-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3QTWM2OD1yLkCxNFc4KM7:TR?= MVPTRW5ITVJ?
IA-LM MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HiRWlEPTB;MD6wNVA5PiEQvF2= NVrzc2xPW0GQR1XS
NB69 M17iT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEGxNFIh|ryP NIfPXmFUSU6JRWK=
C8166 NGG2bYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEGxNlkh|ryP MXvTRW5ITVJ?
NCI-H1299 NWq2U|BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnP[nlkUUN3ME2wMlAyOTV2IN88US=> MmX0V2FPT0WU
YKG-1 NIfvT|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0TWM2OD1yLkCxNVYh|ryP MV\TRW5ITVJ?
PANC-03-27 NWH2WFg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT4OXh7UUN3ME2wMlAyOTZ{IN88US=> MX3TRW5ITVJ?
YT MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKwS3JKSzVyPUCuNFEyPzlizszN NF7rcFlUSU6JRWK=
CAL-85-1 NUC2b5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEGxPVIh|ryP MXPTRW5ITVJ?
GT3TKB Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEGyNFIh|ryP NFHHdIxUSU6JRWK=
BB65-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrXWZRKSzVyPUCuNFEzODRizszN NWm1dG1LW0GQR1XS
ES6 M2XVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:4TWM2OD1yLkCxNlYyKM7:TR?= Mm\IV2FPT0WU
MHH-ES-1 NYDaZnY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLPd|k1UUN3ME2wMlAyOjZ|IN88US=> NGHFZoVUSU6JRWK=
QIMR-WIL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH2RmRKSzVyPUCuNFEzPjlizszN MV3TRW5ITVJ?
SNU-C2B NE\oenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\6[2lEPTB;MD6wNVI4OiEQvF2= M{\tWnNCVkeHUh?=
OCI-AML2 M{XxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;Qb2lEPTB;MD6wNVI5OSEQvF2= MVzTRW5ITVJ?
DU-145 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEGyPUDPxE1? M32zPHNCVkeHUh?=
SW982 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf6W2RKSzVyPUCuNFEzQTNizszN NH7NeINUSU6JRWK=
MFH-ino M{LETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nHbWlEPTB;MD6wNVI6OyEQvF2= NX\lPVU1W0GQR1XS
A427 NIq3dVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEGyPVkh|ryP NXfyN4lZW0GQR1XS
LCLC-97TM1 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkiwTWM2OD1yLkCxN{DPxE1? MlrUV2FPT0WU
AM-38 M{ezXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzoTWM2OD1yLkCxN|AzKM7:TR?= MYfTRW5ITVJ?
K5 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPtTWM2OD1yLkCxN|A5KM7:TR?= NGHDb|ZUSU6JRWK=
T84 NH7xbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf5UJVKSzVyPUCuNFE{OzFizszN NWfz[mVbW0GQR1XS
TE-15 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;yUoZKSzVyPUCuNFE{OzZizszN MVvTRW5ITVJ?
NCI-H460 NIfPVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjKVmJoUUN3ME2wMlAyOzN4IN88US=> MYPTRW5ITVJ?
NTERA-S-cl-D1 M{TSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rQemlEPTB;MD6wNVM{QSEQvF2= M4PiSnNCVkeHUh?=
KYSE-450 M4fJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEGzOFkh|ryP M{Xzd3NCVkeHUh?=
H4 NGq4PHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\1[WlKSzVyPUCuNFE{PjZizszN Mo\aV2FPT0WU
LC-2-ad MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnUVJZEUUN3ME2wMlAyOzdizszN NFi5Z2NUSU6JRWK=
GAMG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17xZ2lEPTB;MD6wNVM4OSEQvF2= Mn31V2FPT0WU
TK10 M2PLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXSTWM2OD1yLkCxN|gzKM7:TR?= NH;pSVRUSU6JRWK=
NCI-H2122 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEGzPFQh|ryP MofzV2FPT0WU
KM12 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrXOGxKSzVyPUCuNFE{QTlizszN NVXCXVU4W0GQR1XS
CAL-39 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PVfGlEPTB;MD6wNVQzKM7:TR?= NEjmOIRUSU6JRWK=
RPMI-2650 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEG0N|Ih|ryP M2G3dHNCVkeHUh?=
KYSE-510 NGPjNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn76TWM2OD1yLkCxOFQzKM7:TR?= NXK3OGFnW0GQR1XS
KALS-1 NGj2S|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIToWIRKSzVyPUCuNFE1PjZizszN M1vHW3NCVkeHUh?=
NCI-H1648 MmO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEG0PVkh|ryP MmjoV2FPT0WU
ES4 NETNb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\mcGlEPTB;MD6wNVUxOiEQvF2= Mmn4V2FPT0WU
C-33-A MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETWXpFKSzVyPUCuNFE2ODlizszN Mn;rV2FPT0WU
MIA-PaCa-2 MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEG1NFkh|ryP MUPTRW5ITVJ?
Becker NHLVbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHzZoZtUUN3ME2wMlAyPTF2IN88US=> MnnKV2FPT0WU
HOP-62 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEG1OFIh|ryP MnHUV2FPT0WU
TE-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zzbmlEPTB;MD6wNVU5OSEQvF2= NWjTe5ZSW0GQR1XS
KYSE-410 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXYSmhuUUN3ME2wMlAyPTh4IN88US=> MUTTRW5ITVJ?
NOS-1 M{\DZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEG1PVMh|ryP MU\TRW5ITVJ?
MEL-HO M2GyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rvV2lEPTB;MD6wNVY1OyEQvF2= MV7TRW5ITVJ?
NCI-H1650 NIjkOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfRTWM2OD1yLkCxOlQ3KM7:TR?= M1yyeXNCVkeHUh?=
VMRC-RCZ NEnQSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;mUWlEPTB;MD6wNVY2OSEQvF2= MU\TRW5ITVJ?
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NCI-H810 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nMeGlEPTB;MD6wNVczPCEQvF2= MVzTRW5ITVJ?
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NCI-H2342 NV\OTFQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4SHFnUUN3ME2wMlAyPzV6IN88US=> NFPsV2JUSU6JRWK=
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MRK-nu-1 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnTW2tKSzVyPUCuNFI{KM7:TR?= MmPTV2FPT0WU
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CAL-62 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHpclhGUUN3ME2wMlAzPTdizszN MV7TRW5ITVJ?
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HN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDwTWM2OD1yLkCyOVk{KM7:TR?= MUfTRW5ITVJ?
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RD MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv0TWM2OD1yLkCyOlU5KM7:TR?= M{i1NXNCVkeHUh?=
NCI-H520 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH73O5NKSzVyPUCuNFI3PjRizszN Mn7wV2FPT0WU
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LB996-RCC MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3STo95UUN3ME2wMlAzPzFizszN NX7yPFY2W0GQR1XS
COR-L23 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEK3NVMh|ryP MULTRW5ITVJ?
GP5d MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jtWGlEPTB;MD6wNlczOyEQvF2= MXnTRW5ITVJ?
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NCI-H2009 M13qU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXHSItvUUN3ME2wMlAzPzZizszN NH\3WYxUSU6JRWK=
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Ca9-22 NXPTPIc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTETWM2OD1yLkCyO|k3KM7:TR?= MmnMV2FPT0WU
SCC-15 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfDTWM2OD1yLkCyPFAyKM7:TR?= M4\yWnNCVkeHUh?=
ETK-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13kUWlEPTB;MD6wNlgxPiEQvF2= NHTvcoFUSU6JRWK=
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EW-1 NV:3U3Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXvN4R[UUN3ME2wMlAzQDJ{IN88US=> NVT0XI14W0GQR1XS
SW962 M2LqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXFNmQ5UUN3ME2wMlAzQDV{IN88US=> M1;RVHNCVkeHUh?=
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NCI-H2405 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTSRnY5UUN3ME2wMlAzQDh5IN88US=> M3TCeHNCVkeHUh?=
A2058 NGi2dXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrIeo1KSzVyPUCuNFI6OjlizszN M{j6eHNCVkeHUh?=
HCC2998 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvETWM2OD1yLkCyPVQ2KM7:TR?= M{ntRXNCVkeHUh?=
ONS-76 M3T5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEK5OVQh|ryP MoD3V2FPT0WU
DBTRG-05MG NVXMSIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEK5OVUh|ryP M3\PVnNCVkeHUh?=
HuCCT1 M2TmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\qXItSUUN3ME2wMlAzQTZzIN88US=> NWTDfWxKW0GQR1XS
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SW837 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13sVWlEPTB;MD6wN|AyPCEQvF2= M{XlXXNCVkeHUh?=
no-10 NYjJeWVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvlTWM2OD1yLkCzNFE3KM7:TR?= NF7hW4NUSU6JRWK=
BC-3 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ITWM2OD1yLkCzNFE5KM7:TR?= NH;jSHZUSU6JRWK=
no-11 NVjZdG02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfsSpA5UUN3ME2wMlA{ODR6IN88US=> NFi5[FFUSU6JRWK=
8305C M2fld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\HRWlEPTB;MD6wN|A4OiEQvF2= NVOwNox3W0GQR1XS
COLO-679 M{PYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0SJo1UUN3ME2wMlA{OTB5IN88US=> NXzENJA4W0GQR1XS
CESS MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEOxNkDPxE1? NVrhUYNWW0GQR1XS
BFTC-909 M4rhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XHOWlEPTB;MD6wN|EzPSEQvF2= MonnV2FPT0WU
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LB831-BLC Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7COFk1UUN3ME2wMlA{OjF7IN88US=> MXHTRW5ITVJ?
SK-UT-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzzNGtLUUN3ME2wMlA{OjJzIN88US=> M3TaTHNCVkeHUh?=
NCI-H1734 M4XxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorFTWM2OD1yLkCzNlMh|ryP Mnu3V2FPT0WU
OVCAR-8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEOyPFEh|ryP M{\aTnNCVkeHUh?=
NCI-H2087 NEPQUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrKTIdDUUN3ME2wMlA{Ojh7IN88US=> MYTTRW5ITVJ?
U-87-MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO5[pVoUUN3ME2wMlA{OjlizszN MX7TRW5ITVJ?
BC-1 NI\tVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEOzOlch|ryP MYjTRW5ITVJ?
ES7 MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEOzO|Qh|ryP M1rmZ3NCVkeHUh?=
Daudi NXrEZ|JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEOzO|Yh|ryP NFyxNXlUSU6JRWK=
RS4-11 M17qPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;2Rng5UUN3ME2wMlA{Ozh|IN88US=> NH30[G5USU6JRWK=
JiyoyeP-2003 NEGy[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPxOnVKSzVyPUCuNFM{QDhizszN MlHMV2FPT0WU
BL-70 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzuVoZqUUN3ME2wMlA{Ozh7IN88US=> Mk\iV2FPT0WU
OS-RC-2 NX\BWoVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki0TWM2OD1yLkCzN|k3KM7:TR?= MonqV2FPT0WU
SF268 NVXwfldCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TaSGlEPTB;MD6wN|QxOSEQvF2= MWHTRW5ITVJ?
BV-173 M1zEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jKUGlEPTB;MD6wN|QzPiEQvF2= NH3LfpNUSU6JRWK=
DMS-273 NHjhO49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1yLkCzOFc6KM7:TR?= MmfLV2FPT0WU
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ES8 M2TveGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;v[pdKSzVyPUCuNFM2OzhizszN M3[1[nNCVkeHUh?=
KYSE-150 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fOc2lEPTB;MD6wN|YxQCEQvF2= M4DUd3NCVkeHUh?=
HCC1569 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;4e2x[UUN3ME2wMlA{PjB6IN88US=> M4DCPXNCVkeHUh?=
NB5 M1TRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEO2NVMh|ryP NULu[o5YW0GQR1XS
G-402 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEO2NVQh|ryP MUPTRW5ITVJ?
NCI-H1693 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvG[JZKSzVyPUCuNFM3OTdizszN M3fsW3NCVkeHUh?=
LB2241-RCC NF:3eWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEO2OFIh|ryP MUDTRW5ITVJ?
KP-4 NV3De|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H2emlEPTB;MD6wN|Y3OyEQvF2= M1\yeHNCVkeHUh?=
ML-2 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHTTWM2OD1yLkCzOlcyKM7:TR?= NV7BfXZoW0GQR1XS
KU812 NH7pO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEO2PFQh|ryP MW\TRW5ITVJ?
LS-411N NYHUUZQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37CNWlEPTB;MD6wN|c{OSEQvF2= MWPTRW5ITVJ?
OAW-42 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID1NG1KSzVyPUCuNFM4PDdizszN MnXGV2FPT0WU
HCC38 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPuTWM2OD1yLkCzO|cyKM7:TR?= MnjjV2FPT0WU
Ca-Ski M1O0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\qVVFKSzVyPUCuNFM4QDRizszN M{SyfHNCVkeHUh?=
Calu-3 NUnLXHJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPNeppmUUN3ME2wMlA{Pzh7IN88US=> MnnCV2FPT0WU
KYSE-70 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nwSWlEPTB;MD6wN|gyOiEQvF2= MUfTRW5ITVJ?
D-392MG NHz3OlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG5dGlKSzVyPUCuNFM5PDJizszN NVPXU5hrW0GQR1XS
OVCAR-4 NG\4eFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\FW2lEPTB;MD6wN|g2QCEQvF2= MVfTRW5ITVJ?
Detroit562 NHHjeFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHiboFmUUN3ME2wMlA{QDd{IN88US=> MV7TRW5ITVJ?
HEL NWLCPIhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r2NmlEPTB;MD6wN|g6OSEQvF2= NX3ye5hjW0GQR1XS
MONO-MAC-6 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfxfZVKSzVyPUCuNFM5QTNizszN NFXES3NUSU6JRWK=
LoVo MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEO5N|Mh|ryP NFXyPZNUSU6JRWK=
U-2-OS MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Hp[GlEPTB;MD6wN|k{PSEQvF2= MnHaV2FPT0WU
A172 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEO5OUDPxE1? Ml\0V2FPT0WU
OCUB-M NWnEUIxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvlO29KSzVyPUCuNFM6PjFizszN NWjsPHpoW0GQR1XS
SW48 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;zcZJKSzVyPUCuNFQxOzFizszN Ml;VV2FPT0WU
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HDLM-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW4NpE4UUN3ME2wMlA1OTF2IN88US=> NUjrOGxtW0GQR1XS
CTV-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMESxNVYh|ryP NITzUJdUSU6JRWK=
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SW756 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjmcJFKSzVyPUCuNFQyPTdizszN M4CxWnNCVkeHUh?=
GCT NVLkbmJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq1TWR[UUN3ME2wMlA1OTZzIN88US=> MVLTRW5ITVJ?
CHL-1 M1j3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOwb|dKSzVyPUCuNFQyPjlizszN NVPmdYRMW0GQR1XS
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LS-1034 M2P5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfRTWM2OD1yLkC0NVkyKM7:TR?= MlfNV2FPT0WU
NCI-H358 NH;XSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K3XWlEPTB;MD6wOFIyOiEQvF2= M2OxWHNCVkeHUh?=
NB13 NIjJVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXezVotKUUN3ME2wMlA1OjJ5IN88US=> MmLLV2FPT0WU
TE-9 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojyTWM2OD1yLkC0NlM4KM7:TR?= M3jOcHNCVkeHUh?=
OE33 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rNVWlEPTB;MD6wOFI1OSEQvF2= NULGb5ZUW0GQR1XS
CAL-120 M3nXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH2TWM2OD1yLkC0NlQyKM7:TR?= M2X6XXNCVkeHUh?=
DJM-1 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\vTWM2OD1yLkC0NlczKM7:TR?= MWrTRW5ITVJ?
SK-MEL-24 M4HY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrjeXdKSzVyPUCuNFQzQDNizszN MnHnV2FPT0WU
VA-ES-BJ NETzdFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ySoh6UUN3ME2wMlA1Ojl{IN88US=> MUfTRW5ITVJ?
MMAC-SF M32zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvRZXBEUUN3ME2wMlA1Ojl5IN88US=> M1rVVHNCVkeHUh?=
MZ7-mel MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4niemlEPTB;MD6wOFM{KM7:TR?= NHn4NVlUSU6JRWK=
BxPC-3 NXzzcIg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vYe2lEPTB;MD6wOFM1OSEQvF2= MUDTRW5ITVJ?
HT-29 NEL2U2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXScIU4UUN3ME2wMlA1OzV5IN88US=> NHKwUYJUSU6JRWK=
SK-MEL-30 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDCXllxUUN3ME2wMlA1OzZ{IN88US=> NGTM[lZUSU6JRWK=
CAL-33 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMESzO|Uh|ryP MlO5V2FPT0WU
COLO-680N MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrVTWM2OD1yLkC0OFA4KM7:TR?= NGLzTWdUSU6JRWK=
NH-12 M3q0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fCUWlEPTB;MD6wOFQ1KM7:TR?= MoX0V2FPT0WU
HCC1937 NVTMUWlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzOeJZKSzVyPUCuNFQ1PTZizszN MUjTRW5ITVJ?
IMR-5 NV3ZRWpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi2S|I{UUN3ME2wMlA1PDlizszN NYS2[nY2W0GQR1XS
MC-CAR NXPRfJd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTETWM2OD1yLkC0OVY6KM7:TR?= M{Wz[HNCVkeHUh?=
NCI-H747 NInGWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHa[G5KSzVyPUCuNFQ2PyEQvF2= NID1RZlUSU6JRWK=
NCI-H1792 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTUTWM2OD1yLkC0OVgyKM7:TR?= MoXuV2FPT0WU
SW13 NWm1b2RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTZTWM2OD1yLkC0OVkh|ryP NYrN[2h4W0GQR1XS
MLMA NXr2XopWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXyU|hIUUN3ME2wMlA1PjB7IN88US=> M{nJZXNCVkeHUh?=
U251 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC3bJp[UUN3ME2wMlA1PzZ|IN88US=> NUTKNId6W0GQR1XS
U031 NWfGbYdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFez[2hKSzVyPUCuNFQ4PzFizszN MYLTRW5ITVJ?
ME-180 M13zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjtOId[UUN3ME2wMlA1Pzh{IN88US=> NV7nRllJW0GQR1XS
SK-MEL-3 M{C0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle4TWM2OD1yLkC0PFAzKM7:TR?= MYHTRW5ITVJ?
MOLT-4 M{XyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMES4NFMh|ryP NXy5TmhoW0GQR1XS
PF-382 NYDQfpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Gxc2lEPTB;MD6wOFgzPiEQvF2= NETaNmlUSU6JRWK=
NUGC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMES4Nlch|ryP MV\TRW5ITVJ?
NCI-H1417 NGDIVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;HeWlEPTB;MD6wOFg6KM7:TR?= NWq5PVlFW0GQR1XS
COLO-205 M3;mXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXpVWR4UUN3ME2wMlA1QTF7IN88US=> NHLHO3RUSU6JRWK=
TE-441-T NGTwbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj6TWM2OD1yLkC0PVMh|ryP MVrTRW5ITVJ?
MKN1 NWr5dYpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mne1TWM2OD1yLkC0PVMh|ryP NXLoT4pIW0GQR1XS
UM-UC-3 NFP4ZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\UN2lEPTB;MD6wOFk2KM7:TR?= NUXVeHFXW0GQR1XS
SF126 M2\lXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEWwNUDPxE1? NF3HVZVUSU6JRWK=
LB1047-RCC M3;jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEWwN|Eh|ryP MofuV2FPT0WU
A253 NYizUYxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrlPFdKSzVyPUCuNFUxPTJizszN NFvBVZpUSU6JRWK=
NCI-H1963 NVvFVFY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\zTWM2OD1yLkC1NVc3KM7:TR?= NHnIU3pUSU6JRWK=
VM-CUB-1 NEPaWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TT[GlEPTB;MD6wOVMyOSEQvF2= MVzTRW5ITVJ?
T-24 NY\kO5dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zsOmlEPTB;MD6wOVM5PCEQvF2= NU\RUVRZW0GQR1XS
K-562 NV7HbHJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEWzPFch|ryP NF7kfmlUSU6JRWK=
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CA46 M3fPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLFNJdKSzVyPUCuNFU1OyEQvF2= M1v3fHNCVkeHUh?=
HCC70 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEW0OVIh|ryP NETvcZhUSU6JRWK=
ST486 NYTXWnpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH5SlJKSzVyPUCuNFU2OjVizszN MYXTRW5ITVJ?
COLO-741 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEW1N|Eh|ryP MXTTRW5ITVJ?
SK-PN-DW M2XFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXDPYlWUUN3ME2wMlA2PTh6IN88US=> NVPreWNqW0GQR1XS
BL-41 M{ftNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HNSGlEPTB;MD6wOVU6PiEQvF2= NIP2Nm1USU6JRWK=
D-263MG MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlywTWM2OD1yLkC1Olg{KM7:TR?= M1S5UXNCVkeHUh?=
KE-37 NXfUepdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEW2PFMh|ryP NFT2[lhUSU6JRWK=
LU-134-A NF3Lfm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO5SZJKSzVyPUCuNFU4OTVizszN NIfoUXFUSU6JRWK=
HCC2157 M{jpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3ES5BpUUN3ME2wMlA2PzN|IN88US=> M{P5VXNCVkeHUh?=
GAK NXvuVJE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:yU2doUUN3ME2wMlA2PzN2IN88US=> NFztdVlUSU6JRWK=
IST-SL2 NIrG[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vtfWlEPTB;MD6wOVc1OyEQvF2= NWnQVJhoW0GQR1XS
KMOE-2 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnpSmF3UUN3ME2wMlA2PzR7IN88US=> NF3wXZRUSU6JRWK=
SW1573 Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjGbG8{UUN3ME2wMlA2QDB{IN88US=> MX3TRW5ITVJ?
SCC-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrGOpZxUUN3ME2wMlA2QDdizszN MUTTRW5ITVJ?
MDA-MB-361 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEW4O|Ih|ryP MWDTRW5ITVJ?
BHT-101 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHhXJZXUUN3ME2wMlA2QDd4IN88US=> NVrvfoR3W0GQR1XS
NCI-H1770 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XMN2lEPTB;MD6wOVg4QSEQvF2= NWrGc41HW0GQR1XS
UACC-893 NHnIVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTxRWpQUUN3ME2wMlA2QDl4IN88US=> M{jqV3NCVkeHUh?=
NCI-H226 M17IcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rkXmlEPTB;MD6wOVk5QCEQvF2= NWm3eWR[W0GQR1XS
HLE MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HPUWlEPTB;MD6wOlA5OiEQvF2= NWXCeolYW0GQR1XS
NCI-H1703 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITEdWZKSzVyPUCuNFYyPzhizszN MXPTRW5ITVJ?
KURAMOCHI NVrFbmhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnniTWM2OD1yLkC2NVg6KM7:TR?= NYDSN5BDW0GQR1XS
RH-1 NUXYV5g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfS[WdKSzVyPUCuNFYzOyEQvF2= NFnzc|hUSU6JRWK=
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CAMA-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrU[3huUUN3ME2wMlA3OzB|IN88US=> MWfTRW5ITVJ?
NCI-H1437 M4[zRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwME[zNlgh|ryP M13I[nNCVkeHUh?=
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HCT-15 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHCS5R1UUN3ME2wMlA3PTl5IN88US=> M{\5UHNCVkeHUh?=
NCCIT NUnqNWdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfmc3FCUUN3ME2wMlA3PjB2IN88US=> MYrTRW5ITVJ?
BOKU M2DBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL4TpdNUUN3ME2wMlA3Pjd2IN88US=> NHXrV3pUSU6JRWK=
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SUP-T1 M2Szb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HFeWlEPTB;MD6wOlc3KM7:TR?= NF\xPYlUSU6JRWK=
L-363 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LVWGlEPTB;MD6wOlkxOSEQvF2= M174N3NCVkeHUh?=
KNS-81-FD M3;hSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\SU2lEPTB;MD6wOlkyQCEQvF2= M2\jcnNCVkeHUh?=
SU-DHL-1 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[5SGhmUUN3ME2wMlA3QTJizszN MlTHV2FPT0WU
HuH-7 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPBfG9KSzVyPUCuNFcxOzVizszN NH;KT4tUSU6JRWK=
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HCC1187 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFwNUW1NlIh|ryP NIC0b4dUSU6JRWK=
EoL-1-cell NV7lVGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\NbZhKSzVyPUGuOVg5QDlizszN MkXqV2FPT0WU
HuO-3N1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonETWM2OD1zLkizOFEzKM7:TR?= MkHqV2FPT0WU
NCI-H1793 M2jRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT6doJKSzVyPUGuPFc2QTNizszN MVHTRW5ITVJ?
Caov-3 NFrwWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHnR2ZIUUN3ME2yMlAxPjJ3IN88US=> MVTTRW5ITVJ?
JAR NYS5eIdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jESmlEPTB;Mj6wO|kzKM7:TR?= M4HFenNCVkeHUh?=
SK-MEL-28 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHpO3RkUUN3ME2yMlE5ODl6IN88US=> M2DST3NCVkeHUh?=
EM-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF70bo5KSzVyPUKuNlAzQTNizszN NX7Ld4g3W0GQR1XS
Mewo MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT4SHpKSzVyPUKuNlIzPjVizszN NVnNXIpLW0GQR1XS
NCI-H720 NWP2cHVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJwMk[1PFUh|ryP NXT0bG1tW0GQR1XS
CAL-54 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwMk[3PVUh|ryP MV3TRW5ITVJ?
MC116 NUjTVopyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\kSIVHUUN3ME2yMlM3Ozl5IN88US=> MX3TRW5ITVJ?
DG-75 M1P2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD4bJNtUUN3ME2yMlQ5PTd4IN88US=> NHLoe|hUSU6JRWK=
HCC1143 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W5bmlEPTB;Mj61NFY2QCEQvF2= NULrSZpzW0GQR1XS
FTC-133 NV7iVXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1myd2lEPTB;Mj61N|Y5QSEQvF2= NW\OeotrW0GQR1XS
AsPC-1 M3LFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDPWoVKSzVyPUKuOVM6OjlizszN NVHtXGNSW0GQR1XS
NCI-H889 M12wSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXZNnNKSzVyPUKuOVY4ODZizszN MXzTRW5ITVJ?
HT55 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPHdFVjUUN3ME2yMlYzODF7IN88US=> NIHhdpZUSU6JRWK=
UMC-11 NFqxe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q3ZWlEPTB;Mj63PFcyPSEQvF2= M3jab3NCVkeHUh?=
P12-ICHIKAWA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuwWXpKSzVyPUKuPFIxPDZizszN NIK2dJJUSU6JRWK=
HCC1395 NHXtcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M361WWlEPTB;Mj65PFYxOiEQvF2= M1rSfHNCVkeHUh?=
D-283MED MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTNwMUi5N|ch|ryP MVfTRW5ITVJ?
COLO-800 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHiTWM2OD1|LkOzPFk4KM7:TR?= M3qxbHNCVkeHUh?=
MFM-223 M3[yXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nNR2lEPTB;Mz6zOlA6PyEQvF2= M3\PUXNCVkeHUh?=
TE-5 NVXIXJBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITXW5hKSzVyPUSuOVYyPDdizszN MnOzV2FPT0WU
NCI-H209 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwN{i1O|Ih|ryP NVnqXodoW0GQR1XS
SiHa MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfCTWM2OD12Lkm1NlA{KM7:TR?= NYftTFhZW0GQR1XS
NCI-H1395 NYrXVlBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTVwMUC2N|Mh|ryP MlrpV2FPT0WU
A498 NYm1U4JXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;MTWM2OD13LkKxNlUyKM7:TR?= NX\xVWFMW0GQR1XS
ES5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[yZmxKSzVyPUWuOlEyPzhizszN NVGwVHpVW0GQR1XS
MDA-MB-157 NVm3eGs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonxTWM2OD13Lk[2OFQ{KM7:TR?= M3LibXNCVkeHUh?=
NCI-H1623 NHTzWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2faR2lEPTB;NT64N|U2PiEQvF2= M2\pW3NCVkeHUh?=
RPMI-8866 NFTMU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\sfFdKSzVyPUWuPFQ4QTJizszN NEfX[XBUSU6JRWK=
LC-1F M1nXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi1fZBKSzVyPU[uNFkzQTFizszN NV;QR5YyW0GQR1XS
TCCSUP NVn0cVBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTZwNkCzOFkh|ryP M2DmSHNCVkeHUh?=
TT NIfVZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rJW2lEPTB;OD6zN|AxQSEQvF2= NVLBTJZEW0GQR1XS
NCI-H1838 NE\EUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\sWGhKSzVyPUiuOVE4OzFizszN MkDiV2FPT0WU
NCI-H322M Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LXVWlEPTB;OT6xOlI5OSEQvF2= M{fB[3NCVkeHUh?=
NCI-H187 M4[yNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO5eFhKSzVyPUmuOVE5OzVizszN NIewR3FUSU6JRWK=
SBC-1 NWn3fm9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTlwOUO2OVYh|ryP NX36NYFRW0GQR1XS
SCC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnGWmtoUUN3ME2xNE42Pjd7IN88US=> NUjtdpp1W0GQR1XS
SW948 NILMcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2PZNZUUN3ME2xNE44PTFzIN88US=> MXnTRW5ITVJ?
CPC-N NULs[XV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFzLkCwO{DPxE1? NITDOW1USU6JRWK=
TGBC24TKB NHzHR|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF|LkWyPUDPxE1? MXfTRW5ITVJ?
NCI-H2452 NXHxUHpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jkcmlEPTB;MUSuO|Mh|ryP MoPmV2FPT0WU
Hs-578-T NIjofotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTCT2FKSzVyPUG4MlU4PTlizszN Ml[zV2FPT0WU
DV-90 NUTt[4RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDjfJRKSzVyPUG4Mlk6PDVizszN MV3TRW5ITVJ?
NCI-H1563 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[xT2lEPTB;MUmuO|g5QCEQvF2= NXPWUWZKW0GQR1XS
SW780 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTWTWM2OD1{MT6xN|E5KM7:TR?= NEG0R2NUSU6JRWK=
NCI-H345 M3HqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTOXIpKSzVyPUKxMlg4PzlizszN NEe0WXZUSU6JRWK=
LB771-HNC M4rzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX6cW1VUUN3ME2yNk41QDF|IN88US=> NIPqfJRUSU6JRWK=
RT4 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[2TWM2OD1{Mz6zNlgzKM7:TR?= M{CzOHNCVkeHUh?=
NCI-H82 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ|LkW1NlYh|ryP NFvIW|dUSU6JRWK=
NCI-H524 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ2LkO4NVIh|ryP MkDnV2FPT0WU
SNU-C1 M37aZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ2LkmxNFUh|ryP MVPTRW5ITVJ?
NCI-SNU-16 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7xXnNKSzVyPUS4MlMyPDJizszN MWjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID