Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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USD 270 In stock
USD 470 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NWrmeWJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDWeZlKSzVyPUCuNFAxOTJ3IN88US=> M{Ti[nNCVkeHUh?=
MV-4-11 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLJTWM2OD1yLkCwNFU2QCEQvF2= MmfBV2FPT0WU
NALM-6 M4LHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{GyNWlEPTB;MD6wNFA5PDJizszN M2Tvb3NCVkeHUh?=
HOS MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHP[olKSzVyPUCuNFAyOzhizszN MWLTRW5ITVJ?
HT-144 M4\yc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnuWpo2UUN3ME2wMlAxOTV3IN88US=> MoHzV2FPT0WU
SW1710 NF\OTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzNTWM2OD1yLkCwNVg3KM7:TR?= MX\TRW5ITVJ?
TE-8 NVrpOolvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S3SGlEPTB;MD6wNFI{PyEQvF2= MmXOV2FPT0WU
ES1 NV3qNmw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPZc3NKSzVyPUCuNFAzPjZizszN MVjTRW5ITVJ?
CCF-STTG1 NWC0WmhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW4NGZKSzVyPUCuNFAzQTdizszN MVTTRW5ITVJ?
PSN1 M4Tn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSyT|FKUUN3ME2wMlAxOzF6IN88US=> NXnYO|JyW0GQR1XS
CAL-51 M2fDWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMECzNlUh|ryP MoqwV2FPT0WU
MCF7 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHQV3dWUUN3ME2wMlAxOzN3IN88US=> MlLiV2FPT0WU
SK-HEP-1 NF:2d41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXvTWM2OD1yLkCwN|M3KM7:TR?= NVTFNJZSW0GQR1XS
LCLC-103H MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr1PYNKSzVyPUCuNFA1OyEQvF2= NF;Xd21USU6JRWK=
HMV-II MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEC0OFkh|ryP NY\MUlU1W0GQR1XS
MES-SA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\BWGlEPTB;MD6wNFQ2OiEQvF2= MXfTRW5ITVJ?
SK-LMS-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHDTWM2OD1yLkCwOFU5KM7:TR?= MVnTRW5ITVJ?
639-V M33EWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEC0PFUh|ryP MmXMV2FPT0WU
SIG-M5 NILJV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnXTWM2OD1yLkCwOFg6KM7:TR?= NF3RVpBUSU6JRWK=
LOUCY M1:0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX0WFk2UUN3ME2wMlAxPTB3IN88US=> MmDKV2FPT0WU
HSC-2 NXXleWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEC1NVgh|ryP NG\Vb3JUSU6JRWK=
EW-13 NH6xNHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi2UYtrUUN3ME2wMlAxPTF6IN88US=> Ml25V2FPT0WU
RT-112 NUTRNpY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHnTWM2OD1yLkCwOVM2KM7:TR?= NV3VeXJ3W0GQR1XS
NKM-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLBTWM2OD1yLkCwOVQ4KM7:TR?= NFXUN2tUSU6JRWK=
KYSE-180 M3myeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnwTFJKUUN3ME2wMlAxPTh4IN88US=> Ml7qV2FPT0WU
SW1783 NIjqfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HQdWlEPTB;MD6wNFU6OSEQvF2= NV7GXlJEW0GQR1XS
A431 NFHETYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPHcVdKSzVyPUCuNFA3ODdizszN MWfTRW5ITVJ?
SK-OV-3 NYfUS|F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvqTWM2OD1yLkCwOlMh|ryP NWmyR2htW0GQR1XS
RPMI-7951 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP3TWM2OD1yLkCwOlMyKM7:TR?= NV;abpBHW0GQR1XS
Capan-2 NHTnfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHGdmNKSzVyPUCuNFA3OzhizszN NEjLNJJUSU6JRWK=
HSC-3 M4S3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEC2OFEh|ryP MmLTV2FPT0WU
786-0 NGLYUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LxcGlEPTB;MD6wNFY3OyEQvF2= M1PJc3NCVkeHUh?=
Daoy MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHBPJJoUUN3ME2wMlAxPjl3IN88US=> M1zsOnNCVkeHUh?=
KGN NGCzcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;MXm5KSzVyPUCuNFA4ODNizszN NEPlUVRUSU6JRWK=
EW-16 NHPQbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPkXm9UUUN3ME2wMlAxPzR7IN88US=> NHroNlZUSU6JRWK=
EW-7 NHTiWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDDTWM2OD1yLkCwO|U1KM7:TR?= NIrEc3lUSU6JRWK=
IGROV-1 NXHISpplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HwUmlEPTB;MD6wNFgyPCEQvF2= NGPu[|NUSU6JRWK=
8505C MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjpWYRKSzVyPUCuNFA5OjFizszN MVfTRW5ITVJ?
RKO MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEC4NlYh|ryP M3XXTnNCVkeHUh?=
GDM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLIVVZKSzVyPUCuNFA5PCEQvF2= Mn[3V2FPT0WU
IST-MEL1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTtR4YzUUN3ME2wMlAxQDV{IN88US=> MU\TRW5ITVJ?
RPMI-6666 NVTl[VZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uyVWlEPTB;MD6wNFg2OiEQvF2= MY\TRW5ITVJ?
SNG-M NYLwPWplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPuTWM2OD1yLkCwPFU3KM7:TR?= MXjTRW5ITVJ?
KS-1 NFn2T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnUTJJrUUN3ME2wMlAxQDV7IN88US=> M4f0bHNCVkeHUh?=
RXF393 M3WwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jU[GlEPTB;MD6wNFg3KM7:TR?= MVrTRW5ITVJ?
CAL-12T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljZTWM2OD1yLkCwPVIzKM7:TR?= MoS2V2FPT0WU
BFTC-905 NF7h[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPzUFRKSzVyPUCuNFA6OzhizszN MnHTV2FPT0WU
SK-MES-1 NFzwWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTVbHFMUUN3ME2wMlAxQTR3IN88US=> M2CzTXNCVkeHUh?=
BB30-HNC M3;WRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qxZ2lEPTB;MD6wNFk2OiEQvF2= M1TDZ3NCVkeHUh?=
AN3-CA M2XQO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7OTWM2OD1yLkCxNFE4KM7:TR?= MnLWV2FPT0WU
EFO-27 NWKxVGk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEGwNVch|ryP NY\q[HR1W0GQR1XS
G-401 M364Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DYemlEPTB;MD6wNVAzPSEQvF2= M4\lVXNCVkeHUh?=
BPH-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;KTWM2OD1yLkCxNFMh|ryP Mm\hV2FPT0WU
NCI-H727 NYrsc|RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPJOIcyUUN3ME2wMlAyODNizszN MlLZV2FPT0WU
SNU-423 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETLXFJKSzVyPUCuNFExPTNizszN NXX2bW92W0GQR1XS
KYSE-270 NXrYPGZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEGwOVkh|ryP NFzYTYlUSU6JRWK=
AGS NUf1PJk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HsNWlEPTB;MD6wNVA3OSEQvF2= MVXTRW5ITVJ?
NCI-H2228 M2fESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rtNWlEPTB;MD6wNVA3PCEQvF2= MonjV2FPT0WU
SW954 M1fwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTQTWM2OD1yLkCxNFcyKM7:TR?= MYTTRW5ITVJ?
769-P NVP0ZplPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTqTWM2OD1yLkCxNFc{KM7:TR?= NVr2cVdHW0GQR1XS
BB49-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fa[2lEPTB;MD6wNVA4PyEQvF2= Ml\rV2FPT0WU
IA-LM MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLRTWM2OD1yLkCxNFg3KM7:TR?= MlG5V2FPT0WU
NB69 MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrhfnlKSzVyPUCuNFEyODJizszN M4DUT3NCVkeHUh?=
C8166 Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDDTZZyUUN3ME2wMlAyOTJ7IN88US=> MYDTRW5ITVJ?
NCI-H1299 NW\XSYNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;hZWlEPTB;MD6wNVE2PCEQvF2= NV3JbmJSW0GQR1XS
YKG-1 Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTMTWM2OD1yLkCxNVYh|ryP NWm3bZI2W0GQR1XS
PANC-03-27 NH;qR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2faOmlEPTB;MD6wNVE3OiEQvF2= NV[1co9SW0GQR1XS
YT NXTiT3VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrXcpJKSzVyPUCuNFEyPzlizszN NUOwc41mW0GQR1XS
CAL-85-1 NHz1WpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCzOVBYUUN3ME2wMlAyOTl{IN88US=> M325XXNCVkeHUh?=
GT3TKB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGyNFIh|ryP M2\TeXNCVkeHUh?=
BB65-RCC NUf3VI5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLYTWM2OD1yLkCxNlA1KM7:TR?= MWDTRW5ITVJ?
ES6 NVXkNlNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj3TWM2OD1yLkCxNlYyKM7:TR?= NEjyNpJUSU6JRWK=
MHH-ES-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEGyOlMh|ryP NHy5[WdUSU6JRWK=
QIMR-WIL M3n1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInzb2hKSzVyPUCuNFEzPjlizszN M2rsW3NCVkeHUh?=
SNU-C2B NXPzcYgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjMU3JrUUN3ME2wMlAyOjd{IN88US=> NXvGfFJjW0GQR1XS
OCI-AML2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzPTWM2OD1yLkCxNlgyKM7:TR?= M{fsVXNCVkeHUh?=
DU-145 M1\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH1NI5KSzVyPUCuNFEzQSEQvF2= NWHae5BTW0GQR1XS
SW982 M4DHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS2SJZKSzVyPUCuNFEzQTNizszN NF;KUW5USU6JRWK=
MFH-ino M1TtdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEGyPVMh|ryP Ml[zV2FPT0WU
A427 M4XIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXaTWM2OD1yLkCxNlk6KM7:TR?= NHzEVnlUSU6JRWK=
LCLC-97TM1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XGZWlEPTB;MD6wNVMh|ryP MWrTRW5ITVJ?
AM-38 NYDne3NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTZTW1KSzVyPUCuNFE{ODJizszN NGLrUW9USU6JRWK=
K5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnZTWM2OD1yLkCxN|A5KM7:TR?= MlzEV2FPT0WU
T84 MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;pTWM2OD1yLkCxN|MyKM7:TR?= MXrTRW5ITVJ?
TE-15 NFXXOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfOV2NuUUN3ME2wMlAyOzN4IN88US=> NILhOphUSU6JRWK=
NCI-H460 NFrzO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrWRpZKSzVyPUCuNFE{OzZizszN M4rsXXNCVkeHUh?=
NTERA-S-cl-D1 M4C1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH4TWM2OD1yLkCxN|M6KM7:TR?= NF;VOJVUSU6JRWK=
KYSE-450 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXOd4NMUUN3ME2wMlAyOzR7IN88US=> M2nMR3NCVkeHUh?=
H4 NULQXFJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYruWI5uUUN3ME2wMlAyOzZ4IN88US=> NWfDS3FmW0GQR1XS
LC-2-ad MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiy[mlDUUN3ME2wMlAyOzdizszN NHTpenpUSU6JRWK=
GAMG NXvaS5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[2TWM2OD1yLkCxN|cyKM7:TR?= MVvTRW5ITVJ?
TK10 M4K0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq4N3U3UUN3ME2wMlAyOzh{IN88US=> M1vNOHNCVkeHUh?=
NCI-H2122 M3nmTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWxT|RDUUN3ME2wMlAyOzh2IN88US=> NX;3Z3RSW0GQR1XS
KM12 NX3LcI9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T3e2lEPTB;MD6wNVM6QSEQvF2= MVjTRW5ITVJ?
CAL-39 NYLQeJFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ixWGlEPTB;MD6wNVQzKM7:TR?= M4m4WnNCVkeHUh?=
RPMI-2650 M4HN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHsTWM2OD1yLkCxOFMzKM7:TR?= MU\TRW5ITVJ?
KYSE-510 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEG0OFIh|ryP M3rqUHNCVkeHUh?=
KALS-1 NXS1SmNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jjUmlEPTB;MD6wNVQ3PiEQvF2= M4GwR3NCVkeHUh?=
NCI-H1648 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHvXItKSzVyPUCuNFE1QTlizszN MmW3V2FPT0WU
ES4 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC3NFh{UUN3ME2wMlAyPTB{IN88US=> M4K0[HNCVkeHUh?=
C-33-A NWGwUVlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXDTWM2OD1yLkCxOVA6KM7:TR?= Ml3NV2FPT0WU
MIA-PaCa-2 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[zbotKSzVyPUCuNFE2ODlizszN MYrTRW5ITVJ?
Becker NV;5dVRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEG1NVQh|ryP M3flSHNCVkeHUh?=
HOP-62 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEG1OFIh|ryP MmPqV2FPT0WU
TE-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEG1PFEh|ryP MXzTRW5ITVJ?
KYSE-410 NXrVb|VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP0N21KSzVyPUCuNFE2QDZizszN MXfTRW5ITVJ?
NOS-1 M33kPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PnNWlEPTB;MD6wNVU6OyEQvF2= NGK3UplUSU6JRWK=
MEL-HO NE[yPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEG2OFMh|ryP NGH6T|VUSU6JRWK=
NCI-H1650 NEnOcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DVT2lEPTB;MD6wNVY1PiEQvF2= MkHCV2FPT0WU
VMRC-RCZ MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEG2OVEh|ryP MVjTRW5ITVJ?
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JiyoyeP-2003 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTtTWM2OD1yLkCzN|g5KM7:TR?= M1OySXNCVkeHUh?=
BL-70 M4\MNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW1ZlZKSzVyPUCuNFM{QDlizszN MUXTRW5ITVJ?
OS-RC-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEOzPVYh|ryP M4HTOXNCVkeHUh?=
SF268 NFTzVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET5dGdKSzVyPUCuNFM1ODFizszN MnHBV2FPT0WU
BV-173 NVqzSY9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXUTWM2OD1yLkCzOFI3KM7:TR?= NHHoPJFUSU6JRWK=
DMS-273 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnyyTWM2OD1yLkCzOFc6KM7:TR?= MXLTRW5ITVJ?
22RV1 NUHvOG1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSyTWM2OD1yLkCzOVA4KM7:TR?= NGPmPGxUSU6JRWK=
ES8 M4n6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEO1N|gh|ryP NY\xNZd7W0GQR1XS
KYSE-150 NV7V[mZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEO2NFgh|ryP NVXYfVRZW0GQR1XS
HCC1569 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrtZlZKSzVyPUCuNFM3ODhizszN M13vNnNCVkeHUh?=
NB5 NH\CcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn3TWM2OD1yLkCzOlE{KM7:TR?= M3fkeXNCVkeHUh?=
G-402 M4HXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjKW5hKSzVyPUCuNFM3OTRizszN MXzTRW5ITVJ?
NCI-H1693 NInWWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInhdlhKSzVyPUCuNFM3OTdizszN NGT4bY9USU6JRWK=
LB2241-RCC NGXwdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEO2OFIh|ryP MYPTRW5ITVJ?
KP-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni2TWM2OD1yLkCzOlY{KM7:TR?= MVLTRW5ITVJ?
ML-2 NV;aW2g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4cWlEPTB;MD6wN|Y4OSEQvF2= M1rOXnNCVkeHUh?=
KU812 NWCyboZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEO2PFQh|ryP NVPtc2lzW0GQR1XS
LS-411N NWTSWHZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH0TWM2OD1yLkCzO|MyKM7:TR?= NUfXRY9iW0GQR1XS
OAW-42 M1fTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInFOHFKSzVyPUCuNFM4PDdizszN MUPTRW5ITVJ?
HCC38 M1i5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;UclZ1UUN3ME2wMlA{PzdzIN88US=> MWTTRW5ITVJ?
Ca-Ski M4TuZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PJeGlEPTB;MD6wN|c5PCEQvF2= MlL3V2FPT0WU
Calu-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT2OnBKSzVyPUCuNFM4QDlizszN MoPtV2FPT0WU
KYSE-70 NUe4S5RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLDbINKSzVyPUCuNFM5OTJizszN NW\OTmNQW0GQR1XS
D-392MG M2fZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofFTWM2OD1yLkCzPFQzKM7:TR?= Mn;oV2FPT0WU
OVCAR-4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ITWM2OD1yLkCzPFU5KM7:TR?= NHTHcZBUSU6JRWK=
Detroit562 M17GT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7wVFlxUUN3ME2wMlA{QDd{IN88US=> NUnuemM5W0GQR1XS
HEL MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH2RlJKSzVyPUCuNFM5QTFizszN M2jFVnNCVkeHUh?=
MONO-MAC-6 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf3[GhjUUN3ME2wMlA{QDl|IN88US=> NILK[mxUSU6JRWK=
LoVo NGnSeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHuTGZKSzVyPUCuNFM6OzNizszN NVnlNmZrW0GQR1XS
U-2-OS NWXrW3drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEO5N|Uh|ryP M1q5cnNCVkeHUh?=
A172 M{nOVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuzboc6UUN3ME2wMlA{QTVizszN NXPMSpVlW0GQR1XS
OCUB-M MnHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHNN3BKSzVyPUCuNFM6PjFizszN NYK4SXV6W0GQR1XS
SW48 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nuXGlEPTB;MD6wOFA{OSEQvF2= M{TCTHNCVkeHUh?=
HC-1 NEfXbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3uzO2lEPTB;MD6wOFA3QSEQvF2= NIfsVmRUSU6JRWK=
KOSC-2 NUjUT4JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTRTWM2OD1yLkC0NVEh|ryP MXPTRW5ITVJ?
HDLM-2 M1[1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\lTWM2OD1yLkC0NVE1KM7:TR?= MV3TRW5ITVJ?
CTV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMESxNVYh|ryP NH;qXFZUSU6JRWK=
SH-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMESxOFEh|ryP NGHtc4pUSU6JRWK=
SW756 NEDsRWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjZfWNKSzVyPUCuNFQyPTdizszN MWrTRW5ITVJ?
GCT NESyPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvLOZRrUUN3ME2wMlA1OTZzIN88US=> MkKxV2FPT0WU
CHL-1 M2rTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rydWlEPTB;MD6wOFE3QSEQvF2= NIn4WXRUSU6JRWK=
LAMA-84 NHHxcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMESxO|Eh|ryP M4nENnNCVkeHUh?=
LS-1034 NGnQTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\Ne5VKSzVyPUCuNFQyQTFizszN NIHsS5dUSU6JRWK=
NCI-H358 NWHQV243T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP6R3RKSzVyPUCuNFQzOTJizszN NYTxV2txW0GQR1XS
NB13 M4PHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPnRoVTUUN3ME2wMlA1OjJ5IN88US=> MoXVV2FPT0WU
TE-9 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzZbplKSzVyPUCuNFQzOzdizszN M17BdnNCVkeHUh?=
OE33 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLHW3FKSzVyPUCuNFQzPDFizszN MojtV2FPT0WU
CAL-120 M{LpOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S2TWlEPTB;MD6wOFI1OSEQvF2= NYnEbWViW0GQR1XS
DJM-1 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL6Tm5KSzVyPUCuNFQzPzJizszN NEKycndUSU6JRWK=
SK-MEL-24 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMESyPFMh|ryP NYjIOmRRW0GQR1XS
VA-ES-BJ NGTp[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXYepJKSzVyPUCuNFQzQTJizszN MnXRV2FPT0WU
MMAC-SF MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;ETWM2OD1yLkC0Nlk4KM7:TR?= M3vEdnNCVkeHUh?=
MZ7-mel NUW2WJl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMESzN{DPxE1? MVvTRW5ITVJ?
BxPC-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfP[Wl3UUN3ME2wMlA1OzRzIN88US=> NHzkSWlUSU6JRWK=
HT-29 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq5TJhoUUN3ME2wMlA1OzV5IN88US=> NXPKVFk1W0GQR1XS
SK-MEL-30 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nv[2lEPTB;MD6wOFM3OiEQvF2= NVjic3FsW0GQR1XS
CAL-33 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO1bXVKSzVyPUCuNFQ{PzVizszN NGexWmVUSU6JRWK=
COLO-680N M1rmXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMES0NFch|ryP MnTRV2FPT0WU
NH-12 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT5b5FKSzVyPUCuNFQ1PCEQvF2= MnewV2FPT0WU
HCC1937 MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnznTWM2OD1yLkC0OFU3KM7:TR?= MofHV2FPT0WU
IMR-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn0dHRKSzVyPUCuNFQ1QSEQvF2= NF3zRoJUSU6JRWK=
MC-CAR M3Lvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi5TWM2OD1yLkC0OVY6KM7:TR?= Mnj4V2FPT0WU
NCI-H747 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[5cWdKSzVyPUCuNFQ2PyEQvF2= MYjTRW5ITVJ?
NCI-H1792 NYnGR4ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTTdYhGUUN3ME2wMlA1PThzIN88US=> MYTTRW5ITVJ?
SW13 NES4eJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WyVWlEPTB;MD6wOFU6KM7:TR?= M{TM[XNCVkeHUh?=
MLMA NXHLbYlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\VbGlEPTB;MD6wOFYxQSEQvF2= NYLFdFd7W0GQR1XS
U251 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m4[2lEPTB;MD6wOFc3OyEQvF2= NUPSfpQ5W0GQR1XS
U031 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zuPGlEPTB;MD6wOFc4OSEQvF2= M{jMT3NCVkeHUh?=
ME-180 NHO2NHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMES3PFIh|ryP NUi1RmJCW0GQR1XS
SK-MEL-3 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;SOWlEPTB;MD6wOFgxOiEQvF2= MXLTRW5ITVJ?
MOLT-4 NYfqeo5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OzemlEPTB;MD6wOFgxOyEQvF2= MWLTRW5ITVJ?
PF-382 NFjpNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n4S2lEPTB;MD6wOFgzPiEQvF2= NHnrV4lUSU6JRWK=
NUGC-3 M1XUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfKTpRKSzVyPUCuNFQ5OjdizszN MojZV2FPT0WU
NCI-H1417 M2rKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT4PYlKSzVyPUCuNFQ5QSEQvF2= M37qPHNCVkeHUh?=
COLO-205 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMES5NVkh|ryP NWPHXoxVW0GQR1XS
TE-441-T NXzMOWF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMES5N{DPxE1? NH7jT3BUSU6JRWK=
MKN1 Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMES5N{DPxE1? NHXzTndUSU6JRWK=
UM-UC-3 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nMd2lEPTB;MD6wOFk2KM7:TR?= M2TjeHNCVkeHUh?=
SF126 M37aXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEWwNUDPxE1? M2flenNCVkeHUh?=
LB1047-RCC MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDHOoJbUUN3ME2wMlA2ODNzIN88US=> NWLPT2dZW0GQR1XS
A253 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jFSWlEPTB;MD6wOVA2OiEQvF2= MUjTRW5ITVJ?
NCI-H1963 M3PTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEWxO|Yh|ryP Mon5V2FPT0WU
VM-CUB-1 NICxZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjafVRKUUN3ME2wMlA2OzFzIN88US=> MWXTRW5ITVJ?
T-24 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH4SIZiUUN3ME2wMlA2Ozh2IN88US=> MnHHV2FPT0WU
K-562 NF65UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPMTphKSzVyPUCuNFU{QDdizszN MX\TRW5ITVJ?
ARH-77 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:3TWM2OD1yLkC1N|k2KM7:TR?= MlzDV2FPT0WU
CA46 NIrYT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTyXGJKSzVyPUCuNFU1OyEQvF2= NWLjOXBQW0GQR1XS
HCC70 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEW0OVIh|ryP MkLtV2FPT0WU
ST486 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TVfWlEPTB;MD6wOVUzPSEQvF2= MWXTRW5ITVJ?
COLO-741 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEW1N|Eh|ryP MV;TRW5ITVJ?
SK-PN-DW NIfvPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlPFZxUUN3ME2wMlA2PTh6IN88US=> NGLMd5RUSU6JRWK=
BL-41 NWm5R|V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzEXphKSzVyPUCuNFU2QTZizszN MmfxV2FPT0WU
D-263MG MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULjc5lbUUN3ME2wMlA2Pjh|IN88US=> Ml;SV2FPT0WU
KE-37 M3HSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\DeINKSzVyPUCuNFU3QDNizszN NUm0SoFWW0GQR1XS
LU-134-A NX\1T21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuyelNKSzVyPUCuNFU4OTVizszN NI[xbldUSU6JRWK=
HCC2157 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HGcmlEPTB;MD6wOVc{OyEQvF2= M3u5ZnNCVkeHUh?=
GAK MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG5TWM2OD1yLkC1O|M1KM7:TR?= M3POXXNCVkeHUh?=
IST-SL2 Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;6NWlEPTB;MD6wOVc1OyEQvF2= NU\5TW42W0GQR1XS
KMOE-2 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz6TWM2OD1yLkC1O|Q6KM7:TR?= NHuwTFlUSU6JRWK=
SW1573 M{\ETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFNWlEPTB;MD6wOVgxOiEQvF2= MomxV2FPT0WU
SCC-9 M3L2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfFOpNrUUN3ME2wMlA2QDdizszN MV3TRW5ITVJ?
MDA-MB-361 M2rwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M322cmlEPTB;MD6wOVg4OiEQvF2= NWDiOnIzW0GQR1XS
BHT-101 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TrUGlEPTB;MD6wOVg4PiEQvF2= MnH2V2FPT0WU
NCI-H1770 M{TubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEW4O|kh|ryP NWfJVWhvW0GQR1XS
UACC-893 NYrTXINUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rPfmlEPTB;MD6wOVg6PiEQvF2= MX3TRW5ITVJ?
NCI-H226 NUjmN2pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Pz[mlEPTB;MD6wOVk5QCEQvF2= NWnFeWhvW0GQR1XS
HLE MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfUPZRFUUN3ME2wMlA3ODh{IN88US=> M3vIW3NCVkeHUh?=
NCI-H1703 NHmzN|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPB[mZKSzVyPUCuNFYyPzhizszN MY\TRW5ITVJ?
KURAMOCHI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwME[xPFkh|ryP MUTTRW5ITVJ?
RH-1 M3HxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O5OWlEPTB;MD6wOlI{KM7:TR?= NX;5NZg6W0GQR1XS
DSH1 M{Kz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwME[yO{DPxE1? MYXTRW5ITVJ?
CAMA-1 M1TY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTJTWM2OD1yLkC2N|A{KM7:TR?= M{XzTXNCVkeHUh?=
NCI-H1437 NHW0Z2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L5XWlEPTB;MD6wOlMzQCEQvF2= NWHpW2RMW0GQR1XS
HuP-T4 M3LmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TxR2lEPTB;MD6wOlU5PiEQvF2= MkXFV2FPT0WU
HCT-15 NFPTdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTpRVFzUUN3ME2wMlA3PTl5IN88US=> M3f3O3NCVkeHUh?=
NCCIT NFrLRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwME[2NFQh|ryP Mne5V2FPT0WU
BOKU MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG0fZpTUUN3ME2wMlA3Pjd2IN88US=> NUXEUng3W0GQR1XS
FADU MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELGPGxKSzVyPUCuNFY4PDVizszN NIPYVGpUSU6JRWK=
SUP-T1 NX\jc4J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwME[3OkDPxE1? NHLuPFNUSU6JRWK=
L-363 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:1VWxUUUN3ME2wMlA3QTBzIN88US=> M4PxSnNCVkeHUh?=
KNS-81-FD NVP5Z4ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzET2tKUUN3ME2wMlA3QTF6IN88US=> MmnoV2FPT0WU
SU-DHL-1 M{Pqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTTTWM2OD1yLkC2PVIh|ryP MWrTRW5ITVJ?
HuH-7 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXGVm5KSzVyPUCuNFcxOzVizszN M{nVcHNCVkeHUh?=
BT-474 M1HyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT3TWM2OD1yLkC3NFYyKM7:TR?= M3\kZnNCVkeHUh?=
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HCC1187 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTFwNUW1NlIh|ryP MmjGV2FPT0WU
EoL-1-cell MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD1zLkW4PFg6KM7:TR?= MnvsV2FPT0WU
HuO-3N1 M1\aRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\6bnRKSzVyPUGuPFM1OTJizszN NHLxUIJUSU6JRWK=
NCI-H1793 NV\aO28zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLaOXc6UUN3ME2xMlg4PTl|IN88US=> NUXtUIJKW0GQR1XS
Caov-3 NXW3[YVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJwMEC2NlUh|ryP M3XQbnNCVkeHUh?=
JAR NViwWlU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jkdGlEPTB;Mj6wO|kzKM7:TR?= NFLxe5ZUSU6JRWK=
SK-MEL-28 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInsWGdKSzVyPUKuNVgxQThizszN M{DCWXNCVkeHUh?=
EM-2 NHewdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDFTWM2OD1{LkKwNlk{KM7:TR?= MVzTRW5ITVJ?
Mewo MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT3VZh{UUN3ME2yMlIzOjZ3IN88US=> NHT4UXBUSU6JRWK=
NCI-H720 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXyXVhKSzVyPUKuNlY2QDVizszN MYDTRW5ITVJ?
CAL-54 NH;IWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwMk[3PVUh|ryP M{f0VXNCVkeHUh?=
MC116 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPkUY9KSzVyPUKuN|Y{QTdizszN MoK3V2FPT0WU
DG-75 NGPOSXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK1TWM2OD1{LkS4OVc3KM7:TR?= NV3kOJFlW0GQR1XS
HCC1143 NGXFTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwNUC2OVgh|ryP NIDGPVFUSU6JRWK=
FTC-133 M{DDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwNUO2PFkh|ryP NHjwZWZUSU6JRWK=
AsPC-1 NYHmdGtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJwNUO5Nlkh|ryP NX7QWnBmW0GQR1XS
NCI-H889 MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHFdYpKSzVyPUKuOVY4ODZizszN M3v0SXNCVkeHUh?=
HT55 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJwNkKwNVkh|ryP MVPTRW5ITVJ?
UMC-11 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwN{i3NVUh|ryP NV\iSG92W0GQR1XS
P12-ICHIKAWA NWjQXJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTWPGJKSzVyPUKuPFIxPDZizszN M13ZeXNCVkeHUh?=
HCC1395 M1f4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTJTWM2OD1{Lkm4OlAzKM7:TR?= M{LJPHNCVkeHUh?=
D-283MED MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwMUi5N|ch|ryP M37yb3NCVkeHUh?=
COLO-800 NIXWOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknLTWM2OD1|LkOzPFk4KM7:TR?= NHrYeXVUSU6JRWK=
MFM-223 M3LacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr2ZYZKSzVyPUOuN|YxQTdizszN MnGzV2FPT0WU
TE-5 M1j5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSyTWM2OD12LkW2NVQ4KM7:TR?= M2j2eHNCVkeHUh?=
NCI-H209 NG\jO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;mN4NOUUN3ME20Mlc5PTd{IN88US=> NVXpO3VJW0GQR1XS
SiHa M2DmWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXMTWM2OD12Lkm1NlA{KM7:TR?= MXvTRW5ITVJ?
NCI-H1395 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELVe|VKSzVyPUWuNVA3OzNizszN MV7TRW5ITVJ?
A498 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjxOYZKSzVyPUWuNlEzPTFizszN MXzTRW5ITVJ?
ES5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy2VnlXUUN3ME21MlYyOTd6IN88US=> NEm2NWNUSU6JRWK=
MDA-MB-157 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTVwNk[0OFMh|ryP NFHFWlhUSU6JRWK=
NCI-H1623 MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;zPGlEPTB;NT64N|U2PiEQvF2= MXfTRW5ITVJ?
RPMI-8866 NH;HPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vWR2lEPTB;NT64OFc6OiEQvF2= NHXw[3NUSU6JRWK=
LC-1F NXj3TGI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTZwMEmyPVEh|ryP Mn:0V2FPT0WU
TCCSUP MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvURpd[UUN3ME22MlYxOzR7IN88US=> NEXCbIZUSU6JRWK=
TT MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vQ[WlEPTB;OD6zN|AxQSEQvF2= MmDSV2FPT0WU
NCI-H1838 NGXKO29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17SOmlEPTB;OD61NVc{OSEQvF2= M{DoeXNCVkeHUh?=
NCI-H322M MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfD[ppKSzVyPUmuNVYzQDFizszN NWT3e3JFW0GQR1XS
NCI-H187 MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\QRWlEPTB;OT61NVg{PSEQvF2= M4XFTXNCVkeHUh?=
SBC-1 NWGyU4tpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInMRVVKSzVyPUmuPVM3PTZizszN MkP2V2FPT0WU
SCC-3 NVvwSmp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfnRXc2UUN3ME2xNE42Pjd7IN88US=> MkKwV2FPT0WU
SW948 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfrTWM2OD1zMD63OVEyKM7:TR?= MYrTRW5ITVJ?
CPC-N MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFzLkCwO{DPxE1? MnjOV2FPT0WU
TGBC24TKB NWW2emRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm1TWM2OD1zMz61Nlkh|ryP MXjTRW5ITVJ?
NCI-H2452 NXHEVG43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPSN4NKSzVyPUG0Mlc{KM7:TR?= M1e1UHNCVkeHUh?=
Hs-578-T M2DsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF6LkW3OVkh|ryP NYPTcohTW0GQR1XS
DV-90 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF6Lkm5OFUh|ryP NV\3NXpnW0GQR1XS
NCI-H1563 NFfPc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrWNJhKSzVyPUG5Mlc5QDhizszN MlriV2FPT0WU
SW780 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTmV2ZKSzVyPUKxMlE{OThizszN MknSV2FPT0WU
NCI-H345 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TVUWlEPTB;MkGuPFc4QSEQvF2= NH7iWoxUSU6JRWK=
LB771-HNC NIfYeoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfx[FRVUUN3ME2yNk41QDF|IN88US=> MVHTRW5ITVJ?
RT4 NHvYeY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmwRZczUUN3ME2yN{4{Ojh{IN88US=> NH60cGdUSU6JRWK=
NCI-H82 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e0U2lEPTB;MkOuOVUzPiEQvF2= MlPJV2FPT0WU
NCI-H524 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDiTWM2OD1{ND6zPFEzKM7:TR?= M3jxUnNCVkeHUh?=
SNU-C1 NUDuSno3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ2LkmxNFUh|ryP MnzaV2FPT0WU
NCI-SNU-16 NIXqTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTrTWM2OD12OD6zNVQzKM7:TR?= MWLTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID