Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 24 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062

Nat Commun, 2014, 5:3361

PubMed: 24553445

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778

Mol Cancer, 2011, 10:125

PubMed: 21962244

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393
J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253

Molecules, 2015, 20(1):1643-60

PubMed: 25608045

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909

PLoS One, 2014, 9(12):e114506

PubMed: 25503774

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed:

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed:

3 Customer Reviews

U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.
Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922 (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	NXr0VW9ST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2PmU2lEPTB;MD6wNFAyOjVizszN	M4m2dnNCVkeHUh?=
MV-4-11	Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjtNHlKSzVyPUCuNFAxPTV6IN88US=>	MoXrV2FPT0WU
NALM-6	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkTjTWM2OD1yLkCwNFg1OiEQvF2=	NGOz[IlUSU6JRWK=
HOS	Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUD2ZZg2UUN3ME2wMlAxOTN6IN88US=>	M1PLUXNCVkeHUh?=
HT-144	M2jWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWjx[mx3UUN3ME2wMlAxOTV3IN88US=>	MkPwV2FPT0WU
SW1710	NVXlbGxCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTHTWM2OD1yLkCwNVg3KM7:TR?=	MW\TRW5ITVJ?
TE-8	MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfWclFRUUN3ME2wMlAxOjN5IN88US=>	NH\FXGxUSU6JRWK=
ES1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmn1TWM2OD1yLkCwNlY3KM7:TR?=	MYjTRW5ITVJ?
CCF-STTG1	NGTZ[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3vKU2lEPTB;MD6wNFI6PyEQvF2=	MoKyV2FPT0WU
PSN1	M2rSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUP5U3VtUUN3ME2wMlAxOzF6IN88US=>	MVnTRW5ITVJ?
CAL-51	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XnW2lEPTB;MD6wNFMzPSEQvF2=	NYfEXFh6W0GQR1XS
MCF7	M2K1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIfPW3hKSzVyPUCuNFA{OzVizszN	Mn7MV2FPT0WU
SK-HEP-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTBwMECzN\|Yh\|ryP	NEDaeY5USU6JRWK=
LCLC-103H	M{TXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUXVSmdYUUN3ME2wMlAxPDNizszN	NI[yWHVUSU6JRWK=
HMV-II	NGrtfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILYPJhKSzVyPUCuNFA1PDlizszN	Mn\BV2FPT0WU
MES-SA	M{j1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTBwMEC0OVIh\|ryP	NVO2e\|dHW0GQR1XS
SK-LMS-1	M{\qRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7SUmJrUUN3ME2wMlAxPDV6IN88US=>	MmK3V2FPT0WU
639-V	MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjXTWM2OD1yLkCwOFg2KM7:TR?=	M1ruTnNCVkeHUh?=
SIG-M5	M3LOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17UV2lEPTB;MD6wNFQ5QSEQvF2=	NXjPNYpHW0GQR1XS
LOUCY	NULMWJdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DSUGlEPTB;MD6wNFUxPSEQvF2=	NGC1U2FUSU6JRWK=
HSC-2	NHLMPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3TeVdKSzVyPUCuNFA2OThizszN	M{S5XXNCVkeHUh?=
EW-13	NEfEZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4T6OGlEPTB;MD6wNFUyQCEQvF2=	NGXldlBUSU6JRWK=
RT-112	NXzKfIR2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF:zXJRKSzVyPUCuNFA2OzVizszN	NF\xU4VUSU6JRWK=
NKM-1	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIK4bXdKSzVyPUCuNFA2PDdizszN	M2\ubnNCVkeHUh?=
KYSE-180	M4P2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn7pTWM2OD1yLkCwOVg3KM7:TR?=	NYrYS5lnW0GQR1XS
SW1783	NFHubHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX\JR\|UxRTBwMEC1PVEh\|ryP	M4L1XHNCVkeHUh?=
A431	M2r1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGnDVnBKSzVyPUCuNFA3ODdizszN	M1K3SHNCVkeHUh?=
SK-OV-3	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1nodGlEPTB;MD6wNFY{KM7:TR?=	M{fqV3NCVkeHUh?=
RPMI-7951	MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DJNGlEPTB;MD6wNFY{OSEQvF2=	NHLYRnVUSU6JRWK=
Capan-2	NH3PeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3nrdWlEPTB;MD6wNFY{QCEQvF2=	NIr2UpJUSU6JRWK=
HSC-3	NVO3SGd2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnS0TWM2OD1yLkCwOlQyKM7:TR?=	MX\TRW5ITVJ?
786-0	M4L6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1PFV2lEPTB;MD6wNFY3OyEQvF2=	MULTRW5ITVJ?
Daoy	MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkLkTWM2OD1yLkCwOlk2KM7:TR?=	MnXEV2FPT0WU
KGN	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2HZdGlEPTB;MD6wNFcxOyEQvF2=	NXy4R2NsW0GQR1XS
EW-16	NFHBZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlvyTWM2OD1yLkCwO\|Q6KM7:TR?=	MVrTRW5ITVJ?
EW-7	MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYjJR\|UxRTBwMEC3OVQh\|ryP	NUjYTHZQW0GQR1XS
IGROV-1	NXvpPHdWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkLjTWM2OD1yLkCwPFE1KM7:TR?=	NXXDeGF[W0GQR1XS
8505C	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PhXWlEPTB;MD6wNFgzOSEQvF2=	M3fnWHNCVkeHUh?=
RKO	M1v6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLyUGxKSzVyPUCuNFA5OjZizszN	NX3TfWxXW0GQR1XS
GDM-1	MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2G4fGlEPTB;MD6wNFg1KM7:TR?=	NF74SlhUSU6JRWK=
IST-MEL1	M2\1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;mcYZmUUN3ME2wMlAxQDV{IN88US=>	NFzxeGdUSU6JRWK=
RPMI-6666	NHvSVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LrOmlEPTB;MD6wNFg2OiEQvF2=	M4jFXHNCVkeHUh?=
SNG-M	NXrB[ppPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4n5cGlEPTB;MD6wNFg2PiEQvF2=	MnrLV2FPT0WU
KS-1	Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWW3OXI2UUN3ME2wMlAxQDV7IN88US=>	MkTFV2FPT0WU
RXF393	Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\BTGlEPTB;MD6wNFg3KM7:TR?=	NVjvWoxFW0GQR1XS
CAL-12T	NH;lO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLmTWM2OD1yLkCwPVIzKM7:TR?=	M1;2fnNCVkeHUh?=
BFTC-905	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmDTTWM2OD1yLkCwPVM5KM7:TR?=	M3vjZXNCVkeHUh?=
SK-MES-1	MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTBwMEC5OFUh\|ryP	M1vtfHNCVkeHUh?=
BB30-HNC	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYnBblk2UUN3ME2wMlAxQTV{IN88US=>	NF\URZFUSU6JRWK=
AN3-CA	NH64OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnoXIpTUUN3ME2wMlAyODF5IN88US=>	M3y5fHNCVkeHUh?=
EFO-27	MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;2OHQ6UUN3ME2wMlAyODF5IN88US=>	MVfTRW5ITVJ?
G-401	M1rOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2HCbWlEPTB;MD6wNVAzPSEQvF2=	MonDV2FPT0WU
BPH-1	NHy5WHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTBwMEGwN{DPxE1?	NUTQV5NMW0GQR1XS
NCI-H727	NWO0boE4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofRTWM2OD1yLkCxNFMh\|ryP	NXLVXm15W0GQR1XS
SNU-423	NXTxR\|ExT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{DzZ2lEPTB;MD6wNVA2OyEQvF2=	NXXiPZVbW0GQR1XS
KYSE-270	M37u[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlTvTWM2OD1yLkCxNFU6KM7:TR?=	MoCxV2FPT0WU
AGS	MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jCNWlEPTB;MD6wNVA3OSEQvF2=	NXzwOHZjW0GQR1XS
NCI-H2228	M3W5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMEGwOlQh\|ryP	MmjiV2FPT0WU
SW954	NXfyN3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zRWGlEPTB;MD6wNVA4OSEQvF2=	MlrUV2FPT0WU
769-P	NFrpTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWjqeVN2UUN3ME2wMlAyODd\|IN88US=>	M4XxUHNCVkeHUh?=
BB49-HNC	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3QTWM2OD1yLkCxNFc4KM7:TR?=	MVPTRW5ITVJ?
IA-LM	MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4HiRWlEPTB;MD6wNVA5PiEQvF2=	NVrzc2xPW0GQR1XS
NB69	M17iT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTBwMEGxNFIh\|ryP	NIfPXmFUSU6JRWK=
C8166	NGG2bYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUTJR\|UxRTBwMEGxNlkh\|ryP	MXvTRW5ITVJ?
NCI-H1299	NWq2U\|BKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVnP[nlkUUN3ME2wMlAyOTV2IN88US=>	MmX0V2FPT0WU
YKG-1	NIfvT\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlH0TWM2OD1yLkCxNVYh\|ryP	MV\TRW5ITVJ?
PANC-03-27	NWH2WFg2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUT4OXh7UUN3ME2wMlAyOTZ{IN88US=>	MX3TRW5ITVJ?
YT	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEKwS3JKSzVyPUCuNFEyPzlizszN	NF7rcFlUSU6JRWK=
CAL-85-1	NUC2b5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTBwMEGxPVIh\|ryP	MXPTRW5ITVJ?
GT3TKB	Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUXJR\|UxRTBwMEGyNFIh\|ryP	NFHHdIxUSU6JRWK=
BB65-RCC	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGrXWZRKSzVyPUCuNFEzODRizszN	NWm1dG1LW0GQR1XS
ES6	M2XVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml:4TWM2OD1yLkCxNlYyKM7:TR?=	Mm\IV2FPT0WU
MHH-ES-1	NYDaZnY1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYLPd\|k1UUN3ME2wMlAyOjZ\|IN88US=>	NGHFZoVUSU6JRWK=
QIMR-WIL	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFH2RmRKSzVyPUCuNFEzPjlizszN	MV3TRW5ITVJ?
SNU-C2B	NE\oenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\6[2lEPTB;MD6wNVI4OiEQvF2=	M{\tWnNCVkeHUh?=
OCI-AML2	M{XxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;Qb2lEPTB;MD6wNVI5OSEQvF2=	MVzTRW5ITVJ?
DU-145	Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTBwMEGyPUDPxE1?	M32zPHNCVkeHUh?=
SW982	MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHf6W2RKSzVyPUCuNFEzQTNizszN	NH7NeINUSU6JRWK=
MFH-ino	M{LETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nHbWlEPTB;MD6wNVI6OyEQvF2=	NX\lPVU1W0GQR1XS
A427	NIq3dVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTBwMEGyPVkh\|ryP	NXfyN4lZW0GQR1XS
LCLC-97TM1	Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkiwTWM2OD1yLkCxN{DPxE1?	MlrUV2FPT0WU
AM-38	M{ezXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlzoTWM2OD1yLkCxN\|AzKM7:TR?=	MYfTRW5ITVJ?
K5	Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPtTWM2OD1yLkCxN\|A5KM7:TR?=	NGHDb\|ZUSU6JRWK=
T84	NH7xbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGf5UJVKSzVyPUCuNFE{OzFizszN	NWfz[mVbW0GQR1XS
TE-15	MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;yUoZKSzVyPUCuNFE{OzZizszN	MVvTRW5ITVJ?
NCI-H460	NIfPVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjKVmJoUUN3ME2wMlAyOzN4IN88US=>	MYPTRW5ITVJ?
NTERA-S-cl-D1	M{TSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2rQemlEPTB;MD6wNVM{QSEQvF2=	M4PiSnNCVkeHUh?=
KYSE-450	M4fJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTBwMEGzOFkh\|ryP	M{Xzd3NCVkeHUh?=
H4	NGq4PHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\1[WlKSzVyPUCuNFE{PjZizszN	Mo\aV2FPT0WU
LC-2-ad	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnUVJZEUUN3ME2wMlAyOzdizszN	NFi5Z2NUSU6JRWK=
GAMG	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M17xZ2lEPTB;MD6wNVM4OSEQvF2=	Mn31V2FPT0WU
TK10	M2PLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXSTWM2OD1yLkCxN\|gzKM7:TR?=	NH;pSVRUSU6JRWK=
NCI-H2122	MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTBwMEGzPFQh\|ryP	MofzV2FPT0WU
KM12	MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFrXOGxKSzVyPUCuNFE{QTlizszN	NVXCXVU4W0GQR1XS
CAL-39	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PVfGlEPTB;MD6wNVQzKM7:TR?=	NEjmOIRUSU6JRWK=
RPMI-2650	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX3JR\|UxRTBwMEG0N\|Ih\|ryP	M2G3dHNCVkeHUh?=
KYSE-510	NGPjNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn76TWM2OD1yLkCxOFQzKM7:TR?=	NXK3OGFnW0GQR1XS
KALS-1	NGj2S\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIToWIRKSzVyPUCuNFE1PjZizszN	M1vHW3NCVkeHUh?=
NCI-H1648	MmO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTBwMEG0PVkh\|ryP	MmjoV2FPT0WU
ES4	NETNb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\mcGlEPTB;MD6wNVUxOiEQvF2=	Mmn4V2FPT0WU
C-33-A	MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETWXpFKSzVyPUCuNFE2ODlizszN	Mn;rV2FPT0WU
MIA-PaCa-2	MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTBwMEG1NFkh\|ryP	MUPTRW5ITVJ?
Becker	NHLVbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHzZoZtUUN3ME2wMlAyPTF2IN88US=>	MnnKV2FPT0WU
HOP-62	Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTBwMEG1OFIh\|ryP	MnHUV2FPT0WU
TE-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1zzbmlEPTB;MD6wNVU5OSEQvF2=	NWjTe5ZSW0GQR1XS
KYSE-410	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXXYSmhuUUN3ME2wMlAyPTh4IN88US=>	MUTTRW5ITVJ?
NOS-1	M{\DZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTBwMEG1PVMh\|ryP	MU\TRW5ITVJ?
MEL-HO	M2GyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4rvV2lEPTB;MD6wNVY1OyEQvF2=	MV7TRW5ITVJ?
NCI-H1650	NIjkOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkfRTWM2OD1yLkCxOlQ3KM7:TR?=	M1yyeXNCVkeHUh?=
VMRC-RCZ	NEnQSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;mUWlEPTB;MD6wNVY2OSEQvF2=	MU\TRW5ITVJ?
HuP-T3	NV23cFFUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7IbWJKSzVyPUCuNFE3PTNizszN	MmTrV2FPT0WU
ACN	M1exRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmOzTWM2OD1yLkCxOlU4KM7:TR?=	MYrTRW5ITVJ?
MEL-JUSO	M37kNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{O0UmlEPTB;MD6wNVY5OSEQvF2=	NVy5RZRzW0GQR1XS
HT-1197	M3vOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;DTWM2OD1yLkCxOlg2KM7:TR?=	MkXZV2FPT0WU
NCI-H2030	NGfVZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3ThSmlEPTB;MD6wNVY6PyEQvF2=	MUHTRW5ITVJ?
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NCI-H292	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYTJR\|UxRTBwMEG3NFkh\|ryP	MYLTRW5ITVJ?
A2780	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDtWFBKSzVyPUCuNFE4OTVizszN	NX\Pd4JDW0GQR1XS
SF295	NW\sTWhST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHrZ3N7UUN3ME2wMlAyPzJzIN88US=>	Ml\hV2FPT0WU
NCI-H810	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nMeGlEPTB;MD6wNVczPCEQvF2=	MVzTRW5ITVJ?
ALL-PO	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknxTWM2OD1yLkCxO\|M2KM7:TR?=	NGjtXppUSU6JRWK=
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NY	NILk[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmOwTWM2OD1yLkCxO\|Qh\|ryP	MVzTRW5ITVJ?
OMC-1	M2fjfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkDUTWM2OD1yLkCxO\|UyKM7:TR?=	NE\YS5hUSU6JRWK=
PANC-10-05	M2W4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF;VVnBKSzVyPUCuNFE4PTVizszN	NH3OXXdUSU6JRWK=
NCI-H2342	NV\OTFQzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVH4SHFnUUN3ME2wMlAyPzV6IN88US=>	NFPsV2JUSU6JRWK=
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TE-12	M2DUfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMEG3O\|Uh\|ryP	MmfEV2FPT0WU
MOLT-16	MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vmN2lEPTB;MD6wNVc5QCEQvF2=	Mn3qV2FPT0WU
HL-60	M4fiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPEcIhKSzVyPUCuNFE5ODdizszN	NGHPbJRUSU6JRWK=
OVCAR-5	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mm\5TWM2OD1yLkCxPFEzKM7:TR?=	M1S4THNCVkeHUh?=
SK-LU-1	M{ezTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwMEG4OFYh\|ryP	NYDDcnhiW0GQR1XS
MG-63	M2rjXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXSTWM2OD1yLkCxPFc1KM7:TR?=	MmfJV2FPT0WU
8-MG-BA	MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2PodmlEPTB;MD6wNVg5PCEQvF2=	NUO3Tot1W0GQR1XS
COR-L105	MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jWNmlEPTB;MD6wNVkyOSEQvF2=	M4TIfnNCVkeHUh?=
BHY	M17TNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7zTWM2OD1yLkCxPVEzKM7:TR?=	MXvTRW5ITVJ?
SW620	M4X5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnzITWM2OD1yLkCxPVE2KM7:TR?=	NUHOOoZbW0GQR1XS
PC-14	Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwMEG5N\|Qh\|ryP	MmnyV2FPT0WU
NCI-H522	NX3aVodET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGXrb4FKSzVyPUCuNFE6OzlizszN	NUPCbll4W0GQR1XS
OE19	NIC1VVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXLJR\|UxRTBwMEG5OUDPxE1?	MVjTRW5ITVJ?
RVH-421	NXvMfZdIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUTRXI8xUUN3ME2wMlAyQTV5IN88US=>	NF7pdZhUSU6JRWK=
TE-10	Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX7JR\|UxRTBwMEG5O\|ch\|ryP	MULTRW5ITVJ?
A101D	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfpTWM2OD1yLkCxPVg4KM7:TR?=	M{i5UXNCVkeHUh?=
HUTU-80	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX3JR\|UxRTBwMEKwNFQh\|ryP	NEmzZoxUSU6JRWK=
KYSE-140	MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXjJR\|UxRTBwMEKwNlQh\|ryP	MXfTRW5ITVJ?
SNU-449	NYC1NGhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrVTZk5UUN3ME2wMlAzODJ4IN88US=>	NYD5[pZCW0GQR1XS
697	M2\je2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmPCTWM2OD1yLkCyNFMyKM7:TR?=	M2\McnNCVkeHUh?=
SJSA-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn7KTWM2OD1yLkCyNFM4KM7:TR?=	NUnvUHM{W0GQR1XS
IGR-1	M4DTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTte2xtUUN3ME2wMlAzODVizszN	MYfTRW5ITVJ?
GCIY	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfJeW1YUUN3ME2wMlAzODV3IN88US=>	M3e4VXNCVkeHUh?=
REH	M{iybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF;vemhKSzVyPUCuNFIxPTlizszN	MU\TRW5ITVJ?
A204	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\xTWM2OD1yLkCyNVE2KM7:TR?=	Ml3LV2FPT0WU
A388	MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2n6WGlEPTB;MD6wNlEyPSEQvF2=	MnvDV2FPT0WU
NCI-H650	MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Moj2TWM2OD1yLkCyNVE4KM7:TR?=	MWHTRW5ITVJ?
SW626	NXj6U4RRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1q1WWlEPTB;MD6wNlEzKM7:TR?=	MlWyV2FPT0WU
DoTc2-4510	M3L0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zx[2lEPTB;MD6wNlEzOiEQvF2=	MmrFV2FPT0WU
HCE-4	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzxemRKSzVyPUCuNFIyPDVizszN	MYjTRW5ITVJ?
DU-4475	NXvC[4dsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEXFd\|VKSzVyPUCuNFIyPSEQvF2=	M{\Jb3NCVkeHUh?=
A375	M4XIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVTJR\|UxRTBwMEKxO\|Eh\|ryP	NHnCXHdUSU6JRWK=
GB-1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnzSTWM2OD1yLkCyNVg5KM7:TR?=	MoniV2FPT0WU
CHP-212	Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnWzTWM2OD1yLkCyNlEzKM7:TR?=	Mkn6V2FPT0WU
HT-1080	NXXROmc1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;yTWM2OD1yLkCyNlE1KM7:TR?=	Mk\5V2FPT0WU
M059J	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmCwTWM2OD1yLkCyNlQyKM7:TR?=	NIXCZoFUSU6JRWK=
NMC-G1	M3nwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fQVWlEPTB;MD6wNlI5KM7:TR?=	MVzTRW5ITVJ?
MRK-nu-1	Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnTW2tKSzVyPUCuNFI{KM7:TR?=	MmPTV2FPT0WU
MFE-296	NGntZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTBwMEKzNlIh\|ryP	M4Tq[nNCVkeHUh?=
LOXIMVI	MoSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVmyW5NCUUN3ME2wMlAzOzJ\|IN88US=>	MluzV2FPT0WU
CGTH-W-1	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MonFTWM2OD1yLkCyN\|I5KM7:TR?=	NWfOVnlPW0GQR1XS
CCRF-CEM	NYjwUmR1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWrPOHNmUUN3ME2wMlAzOzJ7IN88US=>	MmXCV2FPT0WU
ACHN	M1fzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvvSGNoUUN3ME2wMlAzOzR3IN88US=>	NHrLPWFUSU6JRWK=
NCI-H1355	NUfLZ2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTBwMEK0NFEh\|ryP	MnzQV2FPT0WU
NCI-H1651	NGL6NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkLNTWM2OD1yLkCyOFMyKM7:TR?=	NV;T[HoxW0GQR1XS
KINGS-1	NWrvUotST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkjyTWM2OD1yLkCyOFM{KM7:TR?=	M{XhT3NCVkeHUh?=
LS-123	NWP3c2R7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnPYTWM2OD1yLkCyOFM2KM7:TR?=	MlPCV2FPT0WU
SNB75	MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PhRWlEPTB;MD6wNlQ3PiEQvF2=	MnjZV2FPT0WU
C3A	MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTBwMEK0O\|Uh\|ryP	NGDFeFBUSU6JRWK=
HO-1-N-1	NWr1Nng5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYPJR\|UxRTBwMEK1OFkh\|ryP	MYjTRW5ITVJ?
EHEB	Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGTn[IRKSzVyPUCuNFI2PTVizszN	MXLTRW5ITVJ?
CAL-62	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYHpclhGUUN3ME2wMlAzPTdizszN	MV7TRW5ITVJ?
U-118-MG	MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGW1OJVKSzVyPUCuNFI2PzZizszN	M33re3NCVkeHUh?=
HN	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDwTWM2OD1yLkCyOVk{KM7:TR?=	MUfTRW5ITVJ?
HTC-C3	M2PpRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLR[YZsUUN3ME2wMlAzPjB5IN88US=>	MmTiV2FPT0WU
KYSE-520	NFTiPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXu4emlLUUN3ME2wMlAzPjF\|IN88US=>	NVy1WGZ4W0GQR1XS
MZ1-PC	NYXvOGhjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYXTNm9MUUN3ME2wMlAzPjN7IN88US=>	MkTUV2FPT0WU
BCPAP	MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkP5TWM2OD1yLkCyOlQ3KM7:TR?=	NUf2OHRmW0GQR1XS
RD	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mlv0TWM2OD1yLkCyOlU5KM7:TR?=	M{i1NXNCVkeHUh?=
NCI-H520	Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH73O5NKSzVyPUCuNFI3PjRizszN	Mn7wV2FPT0WU
LXF-289	Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XCWmlEPTB;MD6wNlY3QCEQvF2=	NHzBU4lUSU6JRWK=
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LB996-RCC	MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3STo95UUN3ME2wMlAzPzFizszN	NX7yPFY2W0GQR1XS
COR-L23	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTBwMEK3NVMh\|ryP	MULTRW5ITVJ?
GP5d	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2jtWGlEPTB;MD6wNlczOyEQvF2=	MXnTRW5ITVJ?
SW1990	NX7XUmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkXuTWM2OD1yLkCyO\|I1KM7:TR?=	NWLtPHgzW0GQR1XS
PA-1	NImyXWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFj2enZKSzVyPUCuNFI4PTVizszN	NFn6XI1USU6JRWK=
NCI-H2009	M13qU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYXHSItvUUN3ME2wMlAzPzZizszN	NH\3WYxUSU6JRWK=
SR	M1jRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF;TV4hKSzVyPUCuNFI4QDVizszN	MUnTRW5ITVJ?
Ca9-22	NXPTPIc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTETWM2OD1yLkCyO\|k3KM7:TR?=	MmnMV2FPT0WU
SCC-15	MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfDTWM2OD1yLkCyPFAyKM7:TR?=	M4\yWnNCVkeHUh?=
ETK-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13kUWlEPTB;MD6wNlgxPiEQvF2=	NHTvcoFUSU6JRWK=
SCC-4	NWTxRWY5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXPJR\|UxRTBwMEK4NFkh\|ryP	MoLqV2FPT0WU
5637	NEHC[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;jOmlEPTB;MD6wNlgzOiEQvF2=	NGny[mNUSU6JRWK=
EW-1	NV:3U3Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUXvN4R[UUN3ME2wMlAzQDJ{IN88US=>	NVT0XI14W0GQR1XS
SW962	M2LqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXFNmQ5UUN3ME2wMlAzQDV{IN88US=>	M1;RVHNCVkeHUh?=
HCE-T	Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1XCdWlEPTB;MD6wNlg3KM7:TR?=	M1HObnNCVkeHUh?=
NCI-H2405	MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYTSRnY5UUN3ME2wMlAzQDh5IN88US=>	M3TCeHNCVkeHUh?=
A2058	NGi2dXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrIeo1KSzVyPUCuNFI6OjlizszN	M{j6eHNCVkeHUh?=
HCC2998	MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlvETWM2OD1yLkCyPVQ2KM7:TR?=	M{ntRXNCVkeHUh?=
ONS-76	M3T5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWDJR\|UxRTBwMEK5OVQh\|ryP	MoD3V2FPT0WU
DBTRG-05MG	NVXMSIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTBwMEK5OVUh\|ryP	M3\PVnNCVkeHUh?=
HuCCT1	M2TmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\qXItSUUN3ME2wMlAzQTZzIN88US=>	NWTDfWxKW0GQR1XS
J82	MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkTrTWM2OD1yLkCzNFA4KM7:TR?=	M{PXcXNCVkeHUh?=
MKN28	NUjFbZp3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVzJR\|UxRTBwMEOwNVIh\|ryP	M4CzNXNCVkeHUh?=
SW837	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13sVWlEPTB;MD6wN\|AyPCEQvF2=	M{XlXXNCVkeHUh?=
no-10	NYjJeWVET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvlTWM2OD1yLkCzNFE3KM7:TR?=	NF7hW4NUSU6JRWK=
BC-3	MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\ITWM2OD1yLkCzNFE5KM7:TR?=	NH;jSHZUSU6JRWK=
no-11	NVjZdG02T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfsSpA5UUN3ME2wMlA{ODR6IN88US=>	NFi5[FFUSU6JRWK=
8305C	M2fld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3\HRWlEPTB;MD6wN\|A4OiEQvF2=	NVOwNox3W0GQR1XS
COLO-679	M{PYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXv0SJo1UUN3ME2wMlA{OTB5IN88US=>	NXzENJA4W0GQR1XS
CESS	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTBwMEOxNkDPxE1?	NVrhUYNWW0GQR1XS
BFTC-909	M4rhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XHOWlEPTB;MD6wN\|EzPSEQvF2=	MonnV2FPT0WU
MZ2-MEL	M1rRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTBwMEOxO\|ch\|ryP	MVPTRW5ITVJ?
SW872	M{D6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn2zTWM2OD1yLkCzNlE4KM7:TR?=	M2f6NXNCVkeHUh?=
LB831-BLC	Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX7COFk1UUN3ME2wMlA{OjF7IN88US=>	MXHTRW5ITVJ?
SK-UT-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzzNGtLUUN3ME2wMlA{OjJzIN88US=>	M3TaTHNCVkeHUh?=
NCI-H1734	M4XxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorFTWM2OD1yLkCzNlMh\|ryP	Mnu3V2FPT0WU
OVCAR-8	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMEOyPFEh\|ryP	M{\aTnNCVkeHUh?=
NCI-H2087	NEPQUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrKTIdDUUN3ME2wMlA{Ojh7IN88US=>	MYTTRW5ITVJ?
U-87-MG	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVO5[pVoUUN3ME2wMlA{OjlizszN	MX7TRW5ITVJ?
BC-1	NI\tVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTBwMEOzOlch\|ryP	MYjTRW5ITVJ?
ES7	MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXzJR\|UxRTBwMEOzO\|Qh\|ryP	M1rmZ3NCVkeHUh?=
Daudi	NXrEZ\|JpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwMEOzO\|Yh\|ryP	NFyxNXlUSU6JRWK=
RS4-11	M17qPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;2Rng5UUN3ME2wMlA{Ozh\|IN88US=>	NH30[G5USU6JRWK=
JiyoyeP-2003	NEGy[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPxOnVKSzVyPUCuNFM{QDhizszN	MlHMV2FPT0WU
BL-70	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzuVoZqUUN3ME2wMlA{Ozh7IN88US=>	Mk\iV2FPT0WU
OS-RC-2	NX\BWoVrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mki0TWM2OD1yLkCzN\|k3KM7:TR?=	MonqV2FPT0WU
SF268	NVXwfldCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{TaSGlEPTB;MD6wN\|QxOSEQvF2=	MWHTRW5ITVJ?
BV-173	M1zEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jKUGlEPTB;MD6wN\|QzPiEQvF2=	NH3LfpNUSU6JRWK=
DMS-273	NHjhO49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmC4TWM2OD1yLkCzOFc6KM7:TR?=	MmfLV2FPT0WU
22RV1	NF\qNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTBwMEO1NFch\|ryP	NHnTRXFUSU6JRWK=
ES8	M2TveGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF;v[pdKSzVyPUCuNFM2OzhizszN	M3[1[nNCVkeHUh?=
KYSE-150	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fOc2lEPTB;MD6wN\|YxQCEQvF2=	M4DUd3NCVkeHUh?=
HCC1569	MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;4e2x[UUN3ME2wMlA{PjB6IN88US=>	M4DCPXNCVkeHUh?=
NB5	M1TRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwMEO2NVMh\|ryP	NULu[o5YW0GQR1XS
G-402	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTBwMEO2NVQh\|ryP	MUPTRW5ITVJ?
NCI-H1693	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvG[JZKSzVyPUCuNFM3OTdizszN	M3fsW3NCVkeHUh?=
LB2241-RCC	NF:3eWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTBwMEO2OFIh\|ryP	MUDTRW5ITVJ?
KP-4	NV3De\|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3H2emlEPTB;MD6wN\|Y3OyEQvF2=	M1\yeHNCVkeHUh?=
ML-2	MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHTTWM2OD1yLkCzOlcyKM7:TR?=	NV7BfXZoW0GQR1XS
KU812	NH7pO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTBwMEO2PFQh\|ryP	MW\TRW5ITVJ?
LS-411N	NYHUUZQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M37CNWlEPTB;MD6wN\|c{OSEQvF2=	MWPTRW5ITVJ?
OAW-42	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NID1NG1KSzVyPUCuNFM4PDdizszN	MnXGV2FPT0WU
HCC38	MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPuTWM2OD1yLkCzO\|cyKM7:TR?=	MnjjV2FPT0WU
Ca-Ski	M1O0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NI\qVVFKSzVyPUCuNFM4QDRizszN	M{SyfHNCVkeHUh?=
Calu-3	NUnLXHJbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWPNeppmUUN3ME2wMlA{Pzh7IN88US=>	MnnCV2FPT0WU
KYSE-70	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nwSWlEPTB;MD6wN\|gyOiEQvF2=	MUfTRW5ITVJ?
D-392MG	NHz3OlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFG5dGlKSzVyPUCuNFM5PDJizszN	NVPXU5hrW0GQR1XS
OVCAR-4	NG\4eFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1\FW2lEPTB;MD6wN\|g2QCEQvF2=	MVfTRW5ITVJ?
Detroit562	NHHjeFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHiboFmUUN3ME2wMlA{QDd{IN88US=>	MV7TRW5ITVJ?
HEL	NWLCPIhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3r2NmlEPTB;MD6wN\|g6OSEQvF2=	NX3ye5hjW0GQR1XS
MONO-MAC-6	MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIfxfZVKSzVyPUCuNFM5QTNizszN	NFXES3NUSU6JRWK=
LoVo	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTBwMEO5N\|Mh\|ryP	NFXyPZNUSU6JRWK=
U-2-OS	MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2Hp[GlEPTB;MD6wN\|k{PSEQvF2=	MnHaV2FPT0WU
A172	MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTBwMEO5OUDPxE1?	Ml\0V2FPT0WU
OCUB-M	NWnEUIxLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHvlO29KSzVyPUCuNFM6PjFizszN	NWjsPHpoW0GQR1XS
SW48	MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;zcZJKSzVyPUCuNFQxOzFizszN	Ml;VV2FPT0WU
HC-1	NYfFdIdIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTBwMESwOlkh\|ryP	NWL4PVBHW0GQR1XS
KOSC-2	M{XN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLKVnQ2UUN3ME2wMlA1OTFizszN	MV3TRW5ITVJ?
HDLM-2	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVW4NpE4UUN3ME2wMlA1OTF2IN88US=>	NUjrOGxtW0GQR1XS
CTV-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTBwMESxNVYh\|ryP	NITzUJdUSU6JRWK=
SH-4	NYnq[otOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2jXXWlEPTB;MD6wOFE1OSEQvF2=	MoqyV2FPT0WU
SW756	MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjmcJFKSzVyPUCuNFQyPTdizszN	M4CxWnNCVkeHUh?=
GCT	NVLkbmJbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYq1TWR[UUN3ME2wMlA1OTZzIN88US=>	MVLTRW5ITVJ?
CHL-1	M1j3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEOwb\|dKSzVyPUCuNFQyPjlizszN	NVPmdYRMW0GQR1XS
LAMA-84	MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTBwMESxO\|Eh\|ryP	NGPRUVhUSU6JRWK=
LS-1034	M2P5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfRTWM2OD1yLkC0NVkyKM7:TR?=	MlfNV2FPT0WU
NCI-H358	NH;XSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1K3XWlEPTB;MD6wOFIyOiEQvF2=	M2OxWHNCVkeHUh?=
NB13	NIjJVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXezVotKUUN3ME2wMlA1OjJ5IN88US=>	MmLLV2FPT0WU
TE-9	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MojyTWM2OD1yLkC0NlM4KM7:TR?=	M3jOcHNCVkeHUh?=
OE33	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1rNVWlEPTB;MD6wOFI1OSEQvF2=	NULGb5ZUW0GQR1XS
CAL-120	M3nXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmH2TWM2OD1yLkC0NlQyKM7:TR?=	M2X6XXNCVkeHUh?=
DJM-1	MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\vTWM2OD1yLkC0NlczKM7:TR?=	MWrTRW5ITVJ?
SK-MEL-24	M4HY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIrjeXdKSzVyPUCuNFQzQDNizszN	MnHnV2FPT0WU
VA-ES-BJ	NETzdFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;ySoh6UUN3ME2wMlA1Ojl{IN88US=>	MUfTRW5ITVJ?
MMAC-SF	M32zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXvRZXBEUUN3ME2wMlA1Ojl5IN88US=>	M1rVVHNCVkeHUh?=
MZ7-mel	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4niemlEPTB;MD6wOFM{KM7:TR?=	NHn4NVlUSU6JRWK=
BxPC-3	NXzzcIg5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3vYe2lEPTB;MD6wOFM1OSEQvF2=	MUDTRW5ITVJ?
HT-29	NEL2U2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXXScIU4UUN3ME2wMlA1OzV5IN88US=>	NHKwUYJUSU6JRWK=
SK-MEL-30	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUDCXllxUUN3ME2wMlA1OzZ{IN88US=>	NGTM[lZUSU6JRWK=
CAL-33	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTBwMESzO\|Uh\|ryP	MlO5V2FPT0WU
COLO-680N	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmrVTWM2OD1yLkC0OFA4KM7:TR?=	NGLzTWdUSU6JRWK=
NH-12	M3q0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{fCUWlEPTB;MD6wOFQ1KM7:TR?=	MoX0V2FPT0WU
HCC1937	NVTMUWlHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzOeJZKSzVyPUCuNFQ1PTZizszN	MUjTRW5ITVJ?
IMR-5	NV3ZRWpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUi2S\|I{UUN3ME2wMlA1PDlizszN	NYS2[nY2W0GQR1XS
MC-CAR	NXPRfJd2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnTETWM2OD1yLkC0OVY6KM7:TR?=	M{Wz[HNCVkeHUh?=
NCI-H747	NInGWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIHa[G5KSzVyPUCuNFQ2PyEQvF2=	NID1RZlUSU6JRWK=
NCI-H1792	MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTUTWM2OD1yLkC0OVgyKM7:TR?=	MoXuV2FPT0WU
SW13	NWm1b2RbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkTZTWM2OD1yLkC0OVkh\|ryP	NYrN[2h4W0GQR1XS
MLMA	NXr2XopWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUXyU\|hIUUN3ME2wMlA1PjB7IN88US=>	M{nJZXNCVkeHUh?=
U251	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWC3bJp[UUN3ME2wMlA1PzZ\|IN88US=>	NUTKNId6W0GQR1XS
U031	NWfGbYdkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFez[2hKSzVyPUCuNFQ4PzFizszN	MYLTRW5ITVJ?
ME-180	M13zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUjtOId[UUN3ME2wMlA1Pzh{IN88US=>	NV7nRllJW0GQR1XS
SK-MEL-3	M{C0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mle4TWM2OD1yLkC0PFAzKM7:TR?=	MYHTRW5ITVJ?
MOLT-4	M{XyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX\JR\|UxRTBwMES4NFMh\|ryP	NXy5TmhoW0GQR1XS
PF-382	NYDQfpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{Gxc2lEPTB;MD6wOFgzPiEQvF2=	NETaNmlUSU6JRWK=
NUGC-3	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTBwMES4Nlch\|ryP	MV\TRW5ITVJ?
NCI-H1417	NGDIVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;HeWlEPTB;MD6wOFg6KM7:TR?=	NWq5PVlFW0GQR1XS
COLO-205	M3;mXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXpVWR4UUN3ME2wMlA1QTF7IN88US=>	NHLHO3RUSU6JRWK=
TE-441-T	NGTwbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmj6TWM2OD1yLkC0PVMh\|ryP	MVrTRW5ITVJ?
MKN1	NWr5dYpET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mne1TWM2OD1yLkC0PVMh\|ryP	NXLoT4pIW0GQR1XS
UM-UC-3	NFP4ZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\UN2lEPTB;MD6wOFk2KM7:TR?=	NUXVeHFXW0GQR1XS
SF126	M2\lXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTBwMEWwNUDPxE1?	NF3HVZVUSU6JRWK=
LB1047-RCC	M3;jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTBwMEWwN\|Eh\|ryP	MofuV2FPT0WU
A253	NYizUYxpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFrlPFdKSzVyPUCuNFUxPTJizszN	NFvBVZpUSU6JRWK=
NCI-H1963	NVvFVFY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\zTWM2OD1yLkC1NVc3KM7:TR?=	NHnIU3pUSU6JRWK=
VM-CUB-1	NEPaWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2TT[GlEPTB;MD6wOVMyOSEQvF2=	MVzTRW5ITVJ?
T-24	NY\kO5dbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zsOmlEPTB;MD6wOVM5PCEQvF2=	NU\RUVRZW0GQR1XS
K-562	NV7HbHJvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTBwMEWzPFch\|ryP	NF7kfmlUSU6JRWK=
ARH-77	NUP6U5RlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTBwMEWzPVUh\|ryP	MVTTRW5ITVJ?
CA46	M3fPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFLFNJdKSzVyPUCuNFU1OyEQvF2=	M1v3fHNCVkeHUh?=
HCC70	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTBwMEW0OVIh\|ryP	NETvcZhUSU6JRWK=
ST486	NYTXWnpYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFH5SlJKSzVyPUCuNFU2OjVizszN	MYXTRW5ITVJ?
COLO-741	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwMEW1N\|Eh\|ryP	MXTTRW5ITVJ?
SK-PN-DW	M2XFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVXDPYlWUUN3ME2wMlA2PTh6IN88US=>	NVPreWNqW0GQR1XS
BL-41	M{ftNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{HNSGlEPTB;MD6wOVU6PiEQvF2=	NIP2Nm1USU6JRWK=
D-263MG	MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlywTWM2OD1yLkC1Olg{KM7:TR?=	M1S5UXNCVkeHUh?=
KE-37	NXfUepdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTBwMEW2PFMh\|ryP	NFT2[lhUSU6JRWK=
LU-134-A	NF3Lfm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEO5SZJKSzVyPUCuNFU4OTVizszN	NIfoUXFUSU6JRWK=
HCC2157	M{jpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV3ES5BpUUN3ME2wMlA2PzN\|IN88US=>	M{P5VXNCVkeHUh?=
GAK	NXvuVJE6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV:yU2doUUN3ME2wMlA2PzN2IN88US=>	NFztdVlUSU6JRWK=
IST-SL2	NIrG[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1vtfWlEPTB;MD6wOVc1OyEQvF2=	NWnQVJhoW0GQR1XS
KMOE-2	MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVnpSmF3UUN3ME2wMlA2PzR7IN88US=>	NF3wXZRUSU6JRWK=
SW1573	Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjGbG8{UUN3ME2wMlA2QDB{IN88US=>	MX3TRW5ITVJ?
SCC-9	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrGOpZxUUN3ME2wMlA2QDdizszN	MUTTRW5ITVJ?
MDA-MB-361	MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwMEW4O\|Ih\|ryP	MWDTRW5ITVJ?
BHT-101	MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWHhXJZXUUN3ME2wMlA2QDd4IN88US=>	NVrvfoR3W0GQR1XS
NCI-H1770	MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XMN2lEPTB;MD6wOVg4QSEQvF2=	NWrGc41HW0GQR1XS
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IST-SL1	NX3zVnpwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MomyTWM2OD1yLk[wOFM2KM7:TR?=	M3\p[HNCVkeHUh?=
NCI-H2126	Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGTQO3dKSzVyPUCuOlMyPTJizszN	NF7DNnZUSU6JRWK=
HCC1954	NUXYd5hlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTBwNkS3NlYh\|ryP	MYLTRW5ITVJ?
WM-115	NXjzU5lLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1OwV2lEPTB;MD62OVA6OiEQvF2=	NYOxNm5kW0GQR1XS
NB6	MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3fjO2lEPTB;MD62O\|M{PSEQvF2=	NHHnTFBUSU6JRWK=
TYK-nu	M3rKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYi3NXdWUUN3ME2wMlY4QTV{IN88US=>	Moj1V2FPT0WU
KY821	NFu2NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{fQOmlEPTB;MD63NFIzQSEQvF2=	NIP4fXFUSU6JRWK=
SIMA	Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGDSNmVKSzVyPUCuO\|E4OTlizszN	M4\TTHNCVkeHUh?=
RCC10RGB	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo\uTWM2OD1yLkexPVE5KM7:TR?=	Mn3FV2FPT0WU
LN-405	Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFn6cpRKSzVyPUCuO\|Q{PiEQvF2=	NXHmTXhGW0GQR1XS
NCI-H1155	NHXVdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXRTWM2OD1yLke0PFY5KM7:TR?=	NVrlW3c2W0GQR1XS
SCLC-21H	NIW3bWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{HMSmlEPTB;MD63OlkxOyEQvF2=	MoHnV2FPT0WU
DMS-79	NIjncpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTBwN{e4OFUh\|ryP	NIXBTmxUSU6JRWK=
EC-GI-10	M{DmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn\sTWM2OD1yLke3PVc2KM7:TR?=	NGDMNJJUSU6JRWK=
KNS-42	M3\0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLVSIxKSzVyPUCuO\|g5OzFizszN	M{nldHNCVkeHUh?=
SNU-475	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDyTWM2OD1yLke5NlAzKM7:TR?=	MlvzV2FPT0WU
SF539	M1LDfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4PCd2lEPTB;MD63PVkzPSEQvF2=	NGfIcGFUSU6JRWK=
SW1417	NXnHW3ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7ycmhKSzVyPUCuPFE{OzlizszN	M{DLNnNCVkeHUh?=
ATN-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3HEcmlEPTB;MD64OVEyPSEQvF2=	MmD2V2FPT0WU
PLC-PRF-5	NYfyc\|F[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH3qd25KSzVyPUCuPFg1PzVizszN	NWXwR2lVW0GQR1XS
HT-3	M4nwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHq2dm9KSzVyPUCuPFk1OiEQvF2=	MXzTRW5ITVJ?
MDA-MB-453	NY\SeYhHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3KyTWlEPTB;MD65NFMxPCEQvF2=	M3jjbXNCVkeHUh?=
HAL-01	NUPHUZhWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPTd\|JKSzVyPUCuPVk{PzlizszN	NHPYbpZUSU6JRWK=
NCI-H1993	Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1y5W2lEPTB;MT6wOFY2PyEQvF2=	M4fGc3NCVkeHUh?=
NCI-H2227	M1Tqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTFwMES5PFEh\|ryP	MVPTRW5ITVJ?
LP-1	NWjhbnhoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{nBXmlEPTB;MT6wOlk{KM7:TR?=	Mo\OV2FPT0WU
P31-FUJ	MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPt[29KSzVyPUGuNVA4PjZizszN	MkSxV2FPT0WU
NCI-H64	MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPqOXRlUUN3ME2xMlE2PDJizszN	MVHTRW5ITVJ?
SW1463	NWewbHVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWPJR\|UxRTFwMUizOFkh\|ryP	NF21fYFUSU6JRWK=
SK-MEL-1	NI\iOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlrvTWM2OD1zLkKwOVk2KM7:TR?=	NWHTZoRZW0GQR1XS
TALL-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXH1doRqUUN3ME2xMlI2OTZ3IN88US=>	M1fEWnNCVkeHUh?=
RO82-W-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWfJR\|UxRTFwM{OzN\|kh\|ryP	M4rNfHNCVkeHUh?=
NCI-H1581	NGHybVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvFVIxDUUN3ME2xMlM2Pjh5IN88US=>	MkToV2FPT0WU
NCI-H748	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH22NWhKSzVyPUGuN\|U4OzhizszN	MVvTRW5ITVJ?
HCC1187	MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTFwNUW1NlIh\|ryP	NIC0b4dUSU6JRWK=
EoL-1-cell	NV7lVGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\NbZhKSzVyPUGuOVg5QDlizszN	MkXqV2FPT0WU
HuO-3N1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MonETWM2OD1zLkizOFEzKM7:TR?=	MkHqV2FPT0WU
NCI-H1793	M2jRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHT6doJKSzVyPUGuPFc2QTNizszN	MVHTRW5ITVJ?
Caov-3	NFrwWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHnR2ZIUUN3ME2yMlAxPjJ3IN88US=>	MVTTRW5ITVJ?
JAR	NYS5eIdmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jESmlEPTB;Mj6wO\|kzKM7:TR?=	M4HFenNCVkeHUh?=
SK-MEL-28	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVHpO3RkUUN3ME2yMlE5ODl6IN88US=>	M2DST3NCVkeHUh?=
EM-2	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF70bo5KSzVyPUKuNlAzQTNizszN	NX7Ld4g3W0GQR1XS
Mewo	MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGT4SHpKSzVyPUKuNlIzPjVizszN	NVnNXIpLW0GQR1XS
NCI-H720	NWP2cHVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTJwMk[1PFUh\|ryP	NXT0bG1tW0GQR1XS
CAL-54	Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTJwMk[3PVUh\|ryP	MV3TRW5ITVJ?
MC116	NUjTVopyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\kSIVHUUN3ME2yMlM3Ozl5IN88US=>	MX3TRW5ITVJ?
DG-75	M1P2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWD4bJNtUUN3ME2yMlQ5PTd4IN88US=>	NHLoe\|hUSU6JRWK=
HCC1143	Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2W5bmlEPTB;Mj61NFY2QCEQvF2=	NULrSZpzW0GQR1XS
FTC-133	NV7iVXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1myd2lEPTB;Mj61N\|Y5QSEQvF2=	NW\OeotrW0GQR1XS
AsPC-1	M3LFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEDPWoVKSzVyPUKuOVM6OjlizszN	NVHtXGNSW0GQR1XS
NCI-H889	M12wSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXZNnNKSzVyPUKuOVY4ODZizszN	MXzTRW5ITVJ?
HT55	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUPHdFVjUUN3ME2yMlYzODF7IN88US=>	NIHhdpZUSU6JRWK=
UMC-11	NFqxe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1q3ZWlEPTB;Mj63PFcyPSEQvF2=	M3jab3NCVkeHUh?=
P12-ICHIKAWA	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHuwWXpKSzVyPUKuPFIxPDZizszN	NIK2dJJUSU6JRWK=
HCC1395	NHXtcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M361WWlEPTB;Mj65PFYxOiEQvF2=	M1rSfHNCVkeHUh?=
D-283MED	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTNwMUi5N\|ch\|ryP	MVfTRW5ITVJ?
COLO-800	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmHiTWM2OD1\|LkOzPFk4KM7:TR?=	M3qxbHNCVkeHUh?=
MFM-223	M3[yXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nNR2lEPTB;Mz6zOlA6PyEQvF2=	M3\PUXNCVkeHUh?=
TE-5	NVXIXJBST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITXW5hKSzVyPUSuOVYyPDdizszN	MnOzV2FPT0WU
NCI-H209	MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTRwN{i1O\|Ih\|ryP	NVnqXodoW0GQR1XS
SiHa	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfCTWM2OD12Lkm1NlA{KM7:TR?=	NYftTFhZW0GQR1XS
NCI-H1395	NYrXVlBCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXXJR\|UxRTVwMUC2N\|Mh\|ryP	MlrpV2FPT0WU
A498	NYm1U4JXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;MTWM2OD13LkKxNlUyKM7:TR?=	NX\xVWFMW0GQR1XS
ES5	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH[yZmxKSzVyPUWuOlEyPzhizszN	NVGwVHpVW0GQR1XS
MDA-MB-157	NVm3eGs2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MonxTWM2OD13Lk[2OFQ{KM7:TR?=	M3LibXNCVkeHUh?=
NCI-H1623	NHTzWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2faR2lEPTB;NT64N\|U2PiEQvF2=	M2\pW3NCVkeHUh?=
RPMI-8866	NFTMU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\sfFdKSzVyPUWuPFQ4QTJizszN	NEfX[XBUSU6JRWK=
LC-1F	M1nXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIi1fZBKSzVyPU[uNFkzQTFizszN	NV;QR5YyW0GQR1XS
TCCSUP	NVn0cVBlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWfJR\|UxRTZwNkCzOFkh\|ryP	M2DmSHNCVkeHUh?=
TT	NIfVZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2rJW2lEPTB;OD6zN\|AxQSEQvF2=	NVLBTJZEW0GQR1XS
NCI-H1838	NE\EUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\sWGhKSzVyPUiuOVE4OzFizszN	MkDiV2FPT0WU
NCI-H322M	Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LXVWlEPTB;OT6xOlI5OSEQvF2=	M{fB[3NCVkeHUh?=
NCI-H187	M4[yNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGO5eFhKSzVyPUmuOVE5OzVizszN	NIewR3FUSU6JRWK=
SBC-1	NWn3fm9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXnJR\|UxRTlwOUO2OVYh\|ryP	NX36NYFRW0GQR1XS
SCC-3	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnGWmtoUUN3ME2xNE42Pjd7IN88US=>	NUjtdpp1W0GQR1XS
SW948	NILMcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYe2PZNZUUN3ME2xNE44PTFzIN88US=>	MXnTRW5ITVJ?
CPC-N	NULs[XV1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYjJR\|UxRTFzLkCwO{DPxE1?	NITDOW1USU6JRWK=
TGBC24TKB	NHzHR\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTF\|LkWyPUDPxE1?	MXfTRW5ITVJ?
NCI-H2452	NXHxUHpYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4jkcmlEPTB;MUSuO\|Mh\|ryP	MoPmV2FPT0WU
Hs-578-T	NIjofotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTCT2FKSzVyPUG4MlU4PTlizszN	Ml[zV2FPT0WU
DV-90	NUTt[4RuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDjfJRKSzVyPUG4Mlk6PDVizszN	MV3TRW5ITVJ?
NCI-H1563	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1[xT2lEPTB;MUmuO\|g5QCEQvF2=	NXPWUWZKW0GQR1XS
SW780	MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTWTWM2OD1{MT6xN\|E5KM7:TR?=	NEG0R2NUSU6JRWK=
NCI-H345	M3HqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTOXIpKSzVyPUKxMlg4PzlizszN	NEe0WXZUSU6JRWK=
LB771-HNC	M4rzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWX6cW1VUUN3ME2yNk41QDF\|IN88US=>	NIPqfJRUSU6JRWK=
RT4	MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml[2TWM2OD1{Mz6zNlgzKM7:TR?=	M{CzOHNCVkeHUh?=
NCI-H82	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTJ\|LkW1NlYh\|ryP	NFvIW\|dUSU6JRWK=
NCI-H524	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTJ2LkO4NVIh\|ryP	MkDnV2FPT0WU
SNU-C1	M37aZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTJ2LkmxNFUh\|ryP	MVPTRW5ITVJ?
NCI-SNU-16	MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF7xXnNKSzVyPUS4MlMyPDJizszN	MWjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	+ Expand Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	+ Expand Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	+ Expand Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01922583	Completed	Non-small Cell Lung Cancer (NSCLC)	National Taiwan University Hospital	January 2014	Phase 2
NCT01784640	Active not recruiting	Recurrent Non-small Cell Lung Cancer\|Squamous Cell Lung Cancer\|Stage IV Non-small Cell Lung Cancer	Jonsson Comprehensive Cancer Center\|National Cancer Institute (NCI)	January 31 2014	Phase 1
NCT01854034	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	July 2013	Phase 2
NCT01772797	Completed	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products4

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

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Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

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HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 24 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)