Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Cited by 47 Publications

Cancer Cell, 2019, 35(5):752-766

PubMed: 31085176 ( click the link to review the publication )

Nat Med, 2015, 10.1038/nm.3855

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J Neurosci, 2019, 39(17):3332-3344

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BMC Cancer, 2019, 19(1):102

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Transl Lung Cancer Res, 2019, 8(4):340-351

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Mol Cancer Ther, 2019, 18(11):2097-2110

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Clin Cancer Res, 2018, 24(24):6548-6555

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Mol Syst Biol, 2018, 14(3):e7858

PubMed: 29507054 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(3):1792-1804

PubMed: 29363851 ( click the link to review the publication )

Cancer Lett, 2017, 411:19-26

PubMed: 28987383 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2017, 80(4):673-684

PubMed: 28779264 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 487(2):313-319

PubMed: 28412368 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:2219-2226

PubMed: 28458565 ( click the link to review the publication )

Sci Rep, 2017, 7(1):201

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Oncotarget, 2017, 8(35):58771-58780

PubMed: 28938595 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )

J Biol Chem, 2016, 291(19):10332-46

PubMed: 26957545 ( click the link to review the publication )

Horm Cancer, 2016, 7(2):114-26

PubMed: 26858237 ( click the link to review the publication )

PeerJ, 2016, 4:e1683

PubMed: 26893968 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Immun Inflamm Dis, 2016, 4(4):463-473

PubMed: 27980780 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

PubMed: 25982393 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2015, 309(12):L1410-9

PubMed: 26498249 ( click the link to review the publication )
Int J Biol Sci, 2015, 11(8):923-34

PubMed: 26157347 ( click the link to review the publication )

Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0119832

PubMed: 25780909 ( click the link to review the publication )

Oncol Lett, 2015, 10(2):941-945

PubMed: 26622600 ( click the link to review the publication )

Oncotarget, 2015, 6(31):31792-804

PubMed: 26397139 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

PubMed: 24706778 ( click the link to review the publication )

Int J Cancer, 2014, 135(10):2462-74

PubMed: 24706460 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

PubMed: 23972231 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

PLoS One, 2014, 9(12):e114506

PubMed: 25503774 ( click the link to review the publication )

Tumour Biol, 2014, 35(8):8193-9

PubMed: 24850175 ( click the link to review the publication )

Mol Oncol, 2013, 7(6):1093-102

PubMed: 23993685 ( click the link to review the publication )

J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

J Proteome Res, 2013, 12(8):3697-706

PubMed: 23763277 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2013, 273(2):401-9

PubMed: 24090817 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

PubMed: 23209418 ( click the link to review the publication )

Br J Haematol, 2012, 160(4):465-76

PubMed: 23252346 ( click the link to review the publication )

Mol Cell Biochem, 2012, 370(1-2):141-50

PubMed: 22865466 ( click the link to review the publication )

American Society of Clinical Oncology Annual Meeting, 2012, Chicago

PubMed: ( click the link to review the publication )

Mol Cancer, 2011, 10:125

PubMed: 21962244 ( click the link to review the publication )

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description

Targets

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. ^[1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. ^[1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CMK	NH7rflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHLTeY9KSzVyPUCuNFAxOTJ3IN88US=>	NYHsOlNVW0GQR1XS
MV-4-11	NUnO[XlST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;0UlBYUUN3ME2wMlAxODV3ODFOwG0>	MofCV2FPT0WU
NALM-6	M1nRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWrJR\|UxRTBwMECwPFQzKM7:TR?=	MnLXV2FPT0WU
HOS	NX3XOHFwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4Prb2lEPTB;MD6wNFE{QCEQvF2=	Mn3oV2FPT0WU
HT-144	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlntTWM2OD1yLkCwNVU2KM7:TR?=	MYrTRW5ITVJ?
SW1710	NWiyWFhFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVf0RZlVUUN3ME2wMlAxOTh4IN88US=>	MkHZV2FPT0WU
TE-8	NWPxSGt4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmWxTWM2OD1yLkCwNlM4KM7:TR?=	NWi5OHQ5W0GQR1XS
ES1	NYrGSVR1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1\nS2lEPTB;MD6wNFI3PiEQvF2=	Mn3FV2FPT0WU
CCF-STTG1	M4nZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1PaZmlEPTB;MD6wNFI6PyEQvF2=	MXjTRW5ITVJ?
PSN1	NYr1PG5nT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fXWWlEPTB;MD6wNFMyQCEQvF2=	M3T4XHNCVkeHUh?=
CAL-51	MoXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;5TWM2OD1yLkCwN\|I2KM7:TR?=	NF7sOXNUSU6JRWK=
MCF7	NWPpTld{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUniVopHUUN3ME2wMlAxOzN3IN88US=>	M2HLenNCVkeHUh?=
SK-HEP-1	NYGwc3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn\LTWM2OD1yLkCwN\|M3KM7:TR?=	M1;GNXNCVkeHUh?=
LCLC-103H	MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTBwMEC0N{DPxE1?	NFvLT2FUSU6JRWK=
HMV-II	NXn0bHp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1r2fmlEPTB;MD6wNFQ1QSEQvF2=	M2q0TnNCVkeHUh?=
MES-SA	NUj5RYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVqyT29tUUN3ME2wMlAxPDV{IN88US=>	NETuUpRUSU6JRWK=
SK-LMS-1	NV;aV2ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\TNWlEPTB;MD6wNFQ2QCEQvF2=	M33WRXNCVkeHUh?=
639-V	MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTnTWM2OD1yLkCwOFg2KM7:TR?=	MX;TRW5ITVJ?
SIG-M5	NEHRRY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFPWbItKSzVyPUCuNFA1QDlizszN	MkTEV2FPT0WU
LOUCY	NYLjXo1WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3vpbmlEPTB;MD6wNFUxPSEQvF2=	M4jLXnNCVkeHUh?=
HSC-2	M1nZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHHBTHJKSzVyPUCuNFA2OThizszN	NHvTXXhUSU6JRWK=
EW-13	M{XJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMEC1NVgh\|ryP	MoLVV2FPT0WU
RT-112	NV[1SphYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTBwMEC1N\|Uh\|ryP	NV3B[nN[W0GQR1XS
NKM-1	MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTBwMEC1OFch\|ryP	NIfFS5JUSU6JRWK=
KYSE-180	NH\4SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTBwMEC1PFYh\|ryP	Ml;IV2FPT0WU
SW1783	NEPseXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3nnPWlEPTB;MD6wNFU6OSEQvF2=	MoHZV2FPT0WU
A431	Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NID4eGhKSzVyPUCuNFA3ODdizszN	MXfTRW5ITVJ?
SK-OV-3	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MljtTWM2OD1yLkCwOlMh\|ryP	NU\vb3FyW0GQR1XS
RPMI-7951	MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHXEbodKSzVyPUCuNFA3OzFizszN	MmXVV2FPT0WU
Capan-2	NGPlc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\rOHZKSzVyPUCuNFA3OzhizszN	MkDlV2FPT0WU
HSC-3	Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XUUmlEPTB;MD6wNFY1OSEQvF2=	MX\TRW5ITVJ?
786-0	MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnMdVFKSzVyPUCuNFA3PjNizszN	NXfJRYN4W0GQR1XS
Daoy	M4XoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlfxTWM2OD1yLkCwOlk2KM7:TR?=	MkLJV2FPT0WU
KGN	M3\oUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV\JR\|UxRTBwMEC3NFMh\|ryP	M2H3SnNCVkeHUh?=
EW-16	MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfwVotKSzVyPUCuNFA4PDlizszN	MX3TRW5ITVJ?
EW-7	MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG\TUI9KSzVyPUCuNFA4PTRizszN	M2D4enNCVkeHUh?=
IGROV-1	NUTCZ4p7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVfJR\|UxRTBwMEC4NVQh\|ryP	MWXTRW5ITVJ?
8505C	M2Oxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3iyVmlEPTB;MD6wNFgzOSEQvF2=	NHXaT3FUSU6JRWK=
RKO	NGnPc4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnHtTWM2OD1yLkCwPFI3KM7:TR?=	NYnncYROW0GQR1XS
GDM-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfBTWM2OD1yLkCwPFQh\|ryP	MojhV2FPT0WU
IST-MEL1	M2\1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmDuTWM2OD1yLkCwPFUzKM7:TR?=	NXjScGd6W0GQR1XS
RPMI-6666	NVjIfGtKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTBwMEC4OVIh\|ryP	M{LQVnNCVkeHUh?=
SNG-M	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITl[IlKSzVyPUCuNFA5PTZizszN	MmXYV2FPT0WU
KS-1	NUXhWY04T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlO2TWM2OD1yLkCwPFU6KM7:TR?=	NFjlTXdUSU6JRWK=
RXF393	Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DQXGlEPTB;MD6wNFg3KM7:TR?=	NYTae4FFW0GQR1XS
CAL-12T	MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1Hud2lEPTB;MD6wNFkzOiEQvF2=	NUXrOHFmW0GQR1XS
BFTC-905	M3;jU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUezPIQzUUN3ME2wMlAxQTN6IN88US=>	NXLsWWRzW0GQR1XS
SK-MES-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMEC5OFUh\|ryP	NEDzdXZUSU6JRWK=
BB30-HNC	NXfuUmJuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvLTWM2OD1yLkCwPVUzKM7:TR?=	MojLV2FPT0WU
AN3-CA	NWroW2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVPZSZN[UUN3ME2wMlAyODF5IN88US=>	NX3lfJg5W0GQR1XS
EFO-27	NILucXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF;pXGlKSzVyPUCuNFExOTdizszN	NYPVNZVKW0GQR1XS
G-401	NF;RPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml:3TWM2OD1yLkCxNFI2KM7:TR?=	M{\3dHNCVkeHUh?=
BPH-1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUTkS49[UUN3ME2wMlAyODNizszN	NFHP[FJUSU6JRWK=
NCI-H727	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnXPTWM2OD1yLkCxNFMh\|ryP	NIjTRndUSU6JRWK=
SNU-423	NGnCbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHhcotZUUN3ME2wMlAyODV\|IN88US=>	NYC0bW1XW0GQR1XS
KYSE-270	NIS1VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF2xSXNKSzVyPUCuNFExPTlizszN	NFPmZVNUSU6JRWK=
AGS	Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MonKTWM2OD1yLkCxNFYyKM7:TR?=	NYnO[pdRW0GQR1XS
NCI-H2228	NIj5Vo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvIeYZKSzVyPUCuNFExPjRizszN	M4rMdXNCVkeHUh?=
SW954	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4Gzb2lEPTB;MD6wNVA4OSEQvF2=	NWrtSFJsW0GQR1XS
769-P	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYSxPFg4UUN3ME2wMlAyODd\|IN88US=>	NVXXbmYyW0GQR1XS
BB49-HNC	M2Hodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3rqRmlEPTB;MD6wNVA4PyEQvF2=	Mm\HV2FPT0WU
IA-LM	NVXscFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwMEGwPFYh\|ryP	NYT3bGE2W0GQR1XS
NB69	MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTBwMEGxNFIh\|ryP	MYTTRW5ITVJ?
C8166	MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTnTWM2OD1yLkCxNVI6KM7:TR?=	MX3TRW5ITVJ?
NCI-H1299	M1H2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3K5[2lEPTB;MD6wNVE2PCEQvF2=	Mn3uV2FPT0WU
YKG-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzVbWJKSzVyPUCuNFEyPiEQvF2=	MXvTRW5ITVJ?
PANC-03-27	M2G4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV\1SWlvUUN3ME2wMlAyOTZ{IN88US=>	M{TDXHNCVkeHUh?=
YT	M2rwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfBTWM2OD1yLkCxNVc6KM7:TR?=	MWHTRW5ITVJ?
CAL-85-1	MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2joZ2lEPTB;MD6wNVE6OiEQvF2=	NVuxTnRKW0GQR1XS
GT3TKB	NEj5OZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkS2TWM2OD1yLkCxNlAzKM7:TR?=	MnjaV2FPT0WU
BB65-RCC	NVjTR5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH;wbXNKSzVyPUCuNFEzODRizszN	Mkf6V2FPT0WU
ES6	MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTBwMEGyOlEh\|ryP	NVvEVIhJW0GQR1XS
MHH-ES-1	NIK5cllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7CTWM2OD1yLkCxNlY{KM7:TR?=	MkDXV2FPT0WU
QIMR-WIL	NGLWd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXFZXpKSzVyPUCuNFEzPjlizszN	MY\TRW5ITVJ?
SNU-C2B	MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HY[GlEPTB;MD6wNVI4OiEQvF2=	MnLUV2FPT0WU
OCI-AML2	MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1Lz[WlEPTB;MD6wNVI5OSEQvF2=	Mnj0V2FPT0WU
DU-145	NVjtZpFqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPVWIFKSzVyPUCuNFEzQSEQvF2=	M3\3S3NCVkeHUh?=
SW982	NXPjUHlZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTBwMEGyPVMh\|ryP	MlH1V2FPT0WU
MFH-ino	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTBwMEGyPVMh\|ryP	MVLTRW5ITVJ?
A427	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fyR2lEPTB;MD6wNVI6QSEQvF2=	MkDEV2FPT0WU
LCLC-97TM1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXexUFJEUUN3ME2wMlAyOyEQvF2=	MYjTRW5ITVJ?
AM-38	NWrTVmRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFO4T5dKSzVyPUCuNFE{ODJizszN	Mn3YV2FPT0WU
K5	NX\SPHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2GzRmlEPTB;MD6wNVMxQCEQvF2=	NHH4enZUSU6JRWK=
T84	MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTBwMEGzN\|Eh\|ryP	M1rhSHNCVkeHUh?=
TE-15	MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTBwMEGzN\|Yh\|ryP	M2XuUXNCVkeHUh?=
NCI-H460	NXLJeHJCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYnJR\|UxRTBwMEGzN\|Yh\|ryP	NHPWfppUSU6JRWK=
NTERA-S-cl-D1	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTTTWM2OD1yLkCxN\|M6KM7:TR?=	MUPTRW5ITVJ?
KYSE-450	MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXLJR\|UxRTBwMEGzOFkh\|ryP	Ml;xV2FPT0WU
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NCI-H2405	M1\rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XYc2lEPTB;MD6wNlg5PyEQvF2=	NV7jPVFPW0GQR1XS
A2058	M37Sd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLTOlU5UUN3ME2wMlAzQTJ7IN88US=>	MXfTRW5ITVJ?
HCC2998	MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoexTWM2OD1yLkCyPVQ2KM7:TR?=	MWHTRW5ITVJ?
ONS-76	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3lTWM2OD1yLkCyPVU1KM7:TR?=	NX;jdFRZW0GQR1XS
DBTRG-05MG	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTZTWM2OD1yLkCyPVU2KM7:TR?=	MUDTRW5ITVJ?
HuCCT1	NWnOd4d3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1fJZmlEPTB;MD6wNlk3OSEQvF2=	NVPHW25uW0GQR1XS
J82	NUjt[VlDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3yxTGlEPTB;MD6wN\|AxPyEQvF2=	NHz4do5USU6JRWK=
MKN28	M4iwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PWcWlEPTB;MD6wN\|AyOiEQvF2=	MXvTRW5ITVJ?
SW837	MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWnMUFJtUUN3ME2wMlA{ODF2IN88US=>	M3LYe3NCVkeHUh?=
no-10	MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTBwMEOwNVYh\|ryP	NWWxXlZKW0GQR1XS
BC-3	M4Pydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmS5TWM2OD1yLkCzNFE5KM7:TR?=	NFThbWNUSU6JRWK=
no-11	NI\UPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\LTWM2OD1yLkCzNFQ5KM7:TR?=	MVvTRW5ITVJ?
8305C	MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{P3[WlEPTB;MD6wN\|A4OiEQvF2=	MWfTRW5ITVJ?
COLO-679	Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV[we3NNUUN3ME2wMlA{OTB5IN88US=>	NYnxcmVrW0GQR1XS
CESS	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\0TWM2OD1yLkCzNVIh\|ryP	NWPXdWxrW0GQR1XS
BFTC-909	Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYTJR\|UxRTBwMEOxNlUh\|ryP	NHTt[49USU6JRWK=
MZ2-MEL	NWX5NGpCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYfJR\|UxRTBwMEOxO\|ch\|ryP	NF;KVpZUSU6JRWK=
SW872	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDpdW1KSzVyPUCuNFMzOTdizszN	MXLTRW5ITVJ?
LB831-BLC	NEm0WIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTBwMEOyNVkh\|ryP	NYToO2tRW0GQR1XS
SK-UT-1	NYrCdmFxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M136fWlEPTB;MD6wN\|IzOSEQvF2=	M1zNUXNCVkeHUh?=
NCI-H1734	M360[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTBwMEOyN{DPxE1?	NXPHV2k{W0GQR1XS
OVCAR-8	MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPuVVhKSzVyPUCuNFMzQDFizszN	NETwRplUSU6JRWK=
NCI-H2087	Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVjCfGs1UUN3ME2wMlA{Ojh7IN88US=>	M2\HUHNCVkeHUh?=
U-87-MG	NEjnXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYD1Om5sUUN3ME2wMlA{OjlizszN	M1y3OHNCVkeHUh?=
BC-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4TXe2lEPTB;MD6wN\|M3PyEQvF2=	M{nNd3NCVkeHUh?=
ES7	NGDoSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPBTWM2OD1yLkCzN\|c1KM7:TR?=	NGfwS2lUSU6JRWK=
Daudi	M3zWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTzZZFLUUN3ME2wMlA{Ozd4IN88US=>	NH;hRmRUSU6JRWK=
RS4-11	NYXNU4lET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXTJR\|UxRTBwMEOzPFMh\|ryP	NUj3WnpDW0GQR1XS
JiyoyeP-2003	NIXhem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEnzRnRKSzVyPUCuNFM{QDhizszN	NILWOJRUSU6JRWK=
BL-70	NEHO[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;SWIRKSzVyPUCuNFM{QDlizszN	MnrGV2FPT0WU
OS-RC-2	M1XSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTBwMEOzPVYh\|ryP	MoPsV2FPT0WU
SF268	NHjKOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFS4XWhKSzVyPUCuNFM1ODFizszN	NWPMdpVEW0GQR1XS
BV-173	NX6zNJdGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrHbpFKSzVyPUCuNFM1OjZizszN	M{LnSHNCVkeHUh?=
DMS-273	NFjxSnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYDuSGJ4UUN3ME2wMlA{PDd7IN88US=>	NF\zNWxUSU6JRWK=
22RV1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTBwMEO1NFch\|ryP	M1HQeXNCVkeHUh?=
ES8	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTBwMEO1N\|gh\|ryP	NGrveopUSU6JRWK=
KYSE-150	NF65bGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTBwMEO2NFgh\|ryP	NXLoT3dFW0GQR1XS
HCC1569	MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\TTWM2OD1yLkCzOlA5KM7:TR?=	NVjYbIg5W0GQR1XS
NB5	MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3P0TWlEPTB;MD6wN\|YyOyEQvF2=	NVryRXhRW0GQR1XS
G-402	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3T1VGlEPTB;MD6wN\|YyPCEQvF2=	NYWzVYhOW0GQR1XS
NCI-H1693	NHPremZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVnJR\|UxRTBwMEO2NVch\|ryP	NWLmb5VjW0GQR1XS
LB2241-RCC	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF24[WZKSzVyPUCuNFM3PDJizszN	NEHoZWpUSU6JRWK=
KP-4	M3rUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nC[GlEPTB;MD6wN\|Y3OyEQvF2=	NHPnfZZUSU6JRWK=
ML-2	NF7XTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3DdYxKSzVyPUCuNFM3PzFizszN	MmDlV2FPT0WU
KU812	NW\OWpk5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\z[phKSzVyPUCuNFM3QDRizszN	MX3TRW5ITVJ?
LS-411N	NGTXbWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYf3NmNrUUN3ME2wMlA{PzNzIN88US=>	M{Xoc3NCVkeHUh?=
OAW-42	NE\rc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1\PNmlEPTB;MD6wN\|c1PyEQvF2=	NWPCN21qW0GQR1XS
HCC38	M4LNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGrR[YdKSzVyPUCuNFM4PzFizszN	Ml\hV2FPT0WU
Ca-Ski	NIPLOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwMEO3PFQh\|ryP	MYLTRW5ITVJ?
Calu-3	MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTBwMEO3PFkh\|ryP	NUDFUpBNW0GQR1XS
KYSE-70	NXj4bHd3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTBwMEO4NVIh\|ryP	NGLmOGRUSU6JRWK=
D-392MG	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTBwMEO4OFIh\|ryP	NHfEdJNUSU6JRWK=
OVCAR-4	M{TqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHoWoY5UUN3ME2wMlA{QDV6IN88US=>	NV;xdG9wW0GQR1XS
Detroit562	NVfNXXV[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTBwMEO4O\|Ih\|ryP	MnvRV2FPT0WU
HEL	NGjYe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXf6N2s4UUN3ME2wMlA{QDlzIN88US=>	NEHGcIVUSU6JRWK=
MONO-MAC-6	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTBwMEO4PVMh\|ryP	NYLmRVBCW0GQR1XS
LoVo	NF;qPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHVTWM2OD1yLkCzPVM{KM7:TR?=	MmG5V2FPT0WU
U-2-OS	NVnJfYRpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVLPSmRQUUN3ME2wMlA{QTN3IN88US=>	M3PBZ3NCVkeHUh?=
A172	NW\hOlN4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmLFTWM2OD1yLkCzPVUh\|ryP	Mlv6V2FPT0WU
OCUB-M	NITkR5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjJUVcxUUN3ME2wMlA{QTZzIN88US=>	NInocndUSU6JRWK=
SW48	NIHoZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTTd4ZPUUN3ME2wMlA1ODNzIN88US=>	M1zBenNCVkeHUh?=
HC-1	NEPJboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTBwMESwOlkh\|ryP	NFnMWZFUSU6JRWK=
KOSC-2	NX7tOW1MT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUXJR\|UxRTBwMESxNUDPxE1?	MULTRW5ITVJ?
HDLM-2	M1jD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlnXTWM2OD1yLkC0NVE1KM7:TR?=	MXzTRW5ITVJ?
CTV-1	M4DtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF3SS5ZKSzVyPUCuNFQyOTZizszN	NUfmXlVxW0GQR1XS
SH-4	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkLJTWM2OD1yLkC0NVQyKM7:TR?=	MmfWV2FPT0WU
SW756	NVXr[JhiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMESxOVch\|ryP	NEnRRVFUSU6JRWK=
GCT	NFG4cGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTBwMESxOlEh\|ryP	Mo\sV2FPT0WU
CHL-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfuUlNRUUN3ME2wMlA1OTZ7IN88US=>	MYXTRW5ITVJ?
LAMA-84	Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFq5SpdKSzVyPUCuNFQyPzFizszN	Mn7VV2FPT0WU
LS-1034	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTBwMESxPVEh\|ryP	NEP5[JRUSU6JRWK=
NCI-H358	NUHLPFRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHX5RZBKSzVyPUCuNFQzOTJizszN	MWDTRW5ITVJ?
NB13	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{fqNmlEPTB;MD6wOFIzPyEQvF2=	M2nje3NCVkeHUh?=
TE-9	MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVjMS\|hbUUN3ME2wMlA1OjN5IN88US=>	NWjvPXBsW0GQR1XS
OE33	MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWTEfpQ4UUN3ME2wMlA1OjRzIN88US=>	MlvHV2FPT0WU
CAL-120	NUDDV\|VnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVXjUplzUUN3ME2wMlA1OjRzIN88US=>	MXfTRW5ITVJ?
DJM-1	MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mmf5TWM2OD1yLkC0NlczKM7:TR?=	MXPTRW5ITVJ?
SK-MEL-24	M1TuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTBwMESyPFMh\|ryP	M3;RcnNCVkeHUh?=
VA-ES-BJ	NXrNb49xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDHRYFKSzVyPUCuNFQzQTJizszN	NGmzVFJUSU6JRWK=
MMAC-SF	MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2HYTmlEPTB;MD6wOFI6PyEQvF2=	M1PzTnNCVkeHUh?=
MZ7-mel	M2PrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zyU2lEPTB;MD6wOFM{KM7:TR?=	M{W5ZnNCVkeHUh?=
BxPC-3	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXXI[JRsUUN3ME2wMlA1OzRzIN88US=>	NGHwRWRUSU6JRWK=
HT-29	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4DuTGlEPTB;MD6wOFM2PyEQvF2=	MWPTRW5ITVJ?
SK-MEL-30	Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVfFVGpZUUN3ME2wMlA1OzZ{IN88US=>	MoHmV2FPT0WU
CAL-33	M1XRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjmbXpKSzVyPUCuNFQ{PzVizszN	NHfJeHNUSU6JRWK=
COLO-680N	NV3QVJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3rSWWlEPTB;MD6wOFQxPyEQvF2=	MkTmV2FPT0WU
NH-12	M1HBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYeyNVdvUUN3ME2wMlA1PDRizszN	MlW1V2FPT0WU
HCC1937	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTBwMES0OVYh\|ryP	MX\TRW5ITVJ?
IMR-5	M{nHN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLsdYVKSzVyPUCuNFQ1QSEQvF2=	NXXaPZpWW0GQR1XS
MC-CAR	NXzYW4NVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2G0fWlEPTB;MD6wOFU3QSEQvF2=	NF\IfZdUSU6JRWK=
NCI-H747	Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPaTWM2OD1yLkC0OVch\|ryP	NUnCcHp6W0GQR1XS
NCI-H1792	MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIm4cGFKSzVyPUCuNFQ2QDFizszN	M3\QVXNCVkeHUh?=
SW13	NGnOfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\vZXZKSzVyPUCuNFQ2QSEQvF2=	M2HNRnNCVkeHUh?=
MLMA	NXn1WpZmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfQ[\|dKSzVyPUCuNFQ3ODlizszN	M3XOS3NCVkeHUh?=
U251	NVO3PZp{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{HiPGlEPTB;MD6wOFc3OyEQvF2=	MkDUV2FPT0WU
U031	NILCOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEezSlNKSzVyPUCuNFQ4PzFizszN	M3Hk[HNCVkeHUh?=
ME-180	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYrJR\|UxRTBwMES3PFIh\|ryP	M3nEdXNCVkeHUh?=
SK-MEL-3	M4O1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYftPFFGUUN3ME2wMlA1QDB{IN88US=>	M1m5b3NCVkeHUh?=
MOLT-4	MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTBwMES4NFMh\|ryP	NIeySZJUSU6JRWK=
PF-382	Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLaTWM2OD1yLkC0PFI3KM7:TR?=	MlToV2FPT0WU
NUGC-3	M4HPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTBwMES4Nlch\|ryP	M2j3XHNCVkeHUh?=
NCI-H1417	NF34fFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHkTWM2OD1yLkC0PFkh\|ryP	NX;leGw2W0GQR1XS
COLO-205	NITOPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nRTGlEPTB;MD6wOFkyQSEQvF2=	M3LYSnNCVkeHUh?=
TE-441-T	NEnNPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUjJR\|UxRTBwMES5N{DPxE1?	MX7TRW5ITVJ?
MKN1	MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTBwMES5N{DPxE1?	Ml\WV2FPT0WU
UM-UC-3	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DlO2lEPTB;MD6wOFk2KM7:TR?=	MVzTRW5ITVJ?
SF126	NWe5eGdzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVTYN4htUUN3ME2wMlA2ODFizszN	M{HGbHNCVkeHUh?=
LB1047-RCC	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1TvWmlEPTB;MD6wOVA{OSEQvF2=	MkK2V2FPT0WU
A253	MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXqwV\|NLUUN3ME2wMlA2ODV{IN88US=>	Mo\pV2FPT0WU
NCI-H1963	M1;xNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfYOnVKSzVyPUCuNFUyPzZizszN	MUnTRW5ITVJ?
VM-CUB-1	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUTJeFhrUUN3ME2wMlA2OzFzIN88US=>	NHvJe3lUSU6JRWK=
T-24	NG\hclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTBwMEWzPFQh\|ryP	MYPTRW5ITVJ?
K-562	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX7FVYhMUUN3ME2wMlA2Ozh5IN88US=>	NFWxOWVUSU6JRWK=
ARH-77	Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M13GNWlEPTB;MD6wOVM6PSEQvF2=	NWPRb\|Z6W0GQR1XS
CA46	M1T2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jzcGlEPTB;MD6wOVQ{KM7:TR?=	NFjMfWFUSU6JRWK=
HCC70	M2f1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTBwMEW0OVIh\|ryP	NHf5OmFUSU6JRWK=
ST486	NXLhWWw5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1T2T2lEPTB;MD6wOVUzPSEQvF2=	MWjTRW5ITVJ?
COLO-741	MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoGzTWM2OD1yLkC1OVMyKM7:TR?=	NYDDT5J6W0GQR1XS
SK-PN-DW	NH\iO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LhOWlEPTB;MD6wOVU5QCEQvF2=	NUjGNYhYW0GQR1XS
BL-41	NH;hSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NESwVmtKSzVyPUCuNFU2QTZizszN	M3\RNHNCVkeHUh?=
D-263MG	NYXrOJZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2Oz[mlEPTB;MD6wOVY5OyEQvF2=	Ml\HV2FPT0WU
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KMOE-2	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XuZ2lEPTB;MD6wOVc1QSEQvF2=	M{TkUnNCVkeHUh?=
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MDA-MB-361	MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV\ydIdoUUN3ME2wMlA2QDd{IN88US=>	M2rnUnNCVkeHUh?=
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NCI-H1770	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn[yTWM2OD1yLkC1PFc6KM7:TR?=	NH:yXWpUSU6JRWK=
UACC-893	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFTGdWxKSzVyPUCuNFU5QTZizszN	MmL4V2FPT0WU
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NCI-H1703	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHfYWYxKSzVyPUCuNFYyPzhizszN	M4HKdHNCVkeHUh?=
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RH-1	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDnTWM2OD1yLkC2NlMh\|ryP	NWXHe2hFW0GQR1XS
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HEC-1	NV\PUpRoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojKTWM2OD1yLkC3NVYyKM7:TR?=	MlrkV2FPT0WU
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UACC-257	NWfNUnM6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFzOS5VKSzVyPUCuNFc2ODVizszN	NULCSFFOW0GQR1XS
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EW-11	M{\TS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofTTWM2OD1yLkC3OVM2KM7:TR?=	MnG2V2FPT0WU
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PANC-08-13	MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4W2XWlEPTB;MD6wO\|cyPiEQvF2=	MmfWV2FPT0WU
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NCI-N87	MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2L0PGlEPTB;MD6wO\|c6QSEQvF2=	NXzvNHVtW0GQR1XS
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Calu-6	M{n5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWHJR\|UxRTBwMEe5OlUh\|ryP	NW\qdo1IW0GQR1XS
COLO-668	NWrXclU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrEdGhtUUN3ME2wMlA4QTh2IN88US=>	MYjTRW5ITVJ?
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LNCaP-Clone-FGC	MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPtfVVwUUN3ME2wMlA5OTZ3IN88US=>	NFnlVGlUSU6JRWK=
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KP-N-YS	MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TYVmlEPTB;MD6wPFM1PSEQvF2=	MmPNV2FPT0WU
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COLO-792	Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrxWZNLUUN3ME2wMlA5QDV3IN88US=>	NG[3WGJUSU6JRWK=
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MDA-MB-231	NV3iNWxET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;Ee\|RvUUN3ME2wMlA6ODh{IN88US=>	NUHwZ493W0GQR1XS
SBC-5	MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTBwMEmxPVMh\|ryP	MlnCV2FPT0WU
SAS	NWXxWnA4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXDZZdKSzVyPUCuNFkzOTVizszN	M37tVnNCVkeHUh?=
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KARPAS-45	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{HGWWlEPTB;MD6wPVM1PSEQvF2=	MonVV2FPT0WU
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MPP-89	NV7XU\|F7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHCNoRKSzVyPUCuNFk4OjFizszN	MYnTRW5ITVJ?
HT-1376	MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4Dh[GlEPTB;MD6wPVg3OSEQvF2=	M13sW3NCVkeHUh?=
MDA-MB-468	MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MofxTWM2OD1yLkC5PVg2KM7:TR?=	MWfTRW5ITVJ?
HCC2218	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1\JR2lEPTB;MD6wPVk6QSEQvF2=	NUf6VmF2W0GQR1XS
LK-2	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnCeVY4UUN3ME2wMlExOTd4IN88US=>	MXnTRW5ITVJ?
GR-ST	M3;3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMUCyNUDPxE1?	MYLTRW5ITVJ?
PFSK-1	NILPOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTFTWM2OD1yLkGwNlY4KM7:TR?=	Ml;qV2FPT0WU
NCI-H2052	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUnJR\|UxRTBwMUC0NFch\|ryP	NEPW[lZUSU6JRWK=
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EW-18	NGLyPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoTQTWM2OD1yLkGwOlA1KM7:TR?=	M3TMUXNCVkeHUh?=
KU-19-19	MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTBwMUC4NVch\|ryP	NGTD[5pUSU6JRWK=
NCI-H441	NFXYPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTBwMUC4PVkh\|ryP	NWDiWmZPW0GQR1XS
COLO-824	NYPKeINzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLhNpE2UUN3ME2wMlEyODJizszN	M1T4RXNCVkeHUh?=
HCC1806	NH\PXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{j4ZWlEPTB;MD6xNVExQCEQvF2=	M4fvO3NCVkeHUh?=
SK-MM-2	NIDHd2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4q0fGlEPTB;MD6xNVE1PSEQvF2=	M3PGZ3NCVkeHUh?=
DEL	MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHXKSWxKSzVyPUCuNVEyQTJizszN	M4PTZnNCVkeHUh?=
NCI-H661	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjNbY1KSzVyPUCuNVEyQTVizszN	MUDTRW5ITVJ?
LC4-1	NX;yeINtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmPITWM2OD1yLkGxOFY3KM7:TR?=	MlLUV2FPT0WU
BEN	MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MofPTWM2OD1yLkGxOlA4KM7:TR?=	M4fsSnNCVkeHUh?=
RPMI-8226	NXz1NoQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTBwMUG3NVkh\|ryP	MYLTRW5ITVJ?
AU565	M1q5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTBwMUG4N\|Eh\|ryP	NGXEUnpUSU6JRWK=
CAS-1	MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoOzTWM2OD1yLkGxPVY1KM7:TR?=	Mmf4V2FPT0WU
UACC-62	NYDpZWM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXnJR\|UxRTBwMUKxNkDPxE1?	MUjTRW5ITVJ?
C-4-II	Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGPT[lVKSzVyPUCuNVIyPyEQvF2=	NUPJS4xCW0GQR1XS
DMS-53	NFK1[ZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWn2XFliUUN3ME2wMlEzOjd4IN88US=>	MnTFV2FPT0WU
SK-MEL-2	MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7DVWtKSzVyPUCuNVI1PiEQvF2=	NIDlSVZUSU6JRWK=
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NCI-H716	MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTBwNES4OFgh\|ryP	NH;YWHRUSU6JRWK=
NEC8	M3;NU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmHFTWM2OD1yLkS1NVQ2KM7:TR?=	NInqV3ZUSU6JRWK=
UACC-812	NGHwTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{mzV2lEPTB;MD60Olc4PiEQvF2=	NH7oRpVUSU6JRWK=
D-502MG	NUfCb5FqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\WN3lKSzVyPUCuOFgxOyEQvF2=	M1fr[XNCVkeHUh?=
CaR-1	NInhXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYfVWFZtUUN3ME2wMlUxOzZ5IN88US=>	MYPTRW5ITVJ?
LU-139	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkPjTWM2OD1yLkWxOFU4KM7:TR?=	MVnTRW5ITVJ?
RPMI-8402	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHTMW\|lKSzVyPUCuOVIzODdizszN	MkTKV2FPT0WU
SW1088	M2DQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTBwNUO4Olkh\|ryP	NEnH[4VUSU6JRWK=
JVM-3	NVj0OZpIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NILKU3NKSzVyPUCuOVQyOTdizszN	NIixVJVUSU6JRWK=
YAPC	NXLvU2NGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXHLOXZQUUN3ME2wMlU2OjFzIN88US=>	MX;TRW5ITVJ?
KG-1	Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTBwNUW5PFQh\|ryP	M3zVbHNCVkeHUh?=
C32	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2foOmlEPTB;MD61O\|MyOyEQvF2=	M1XZVXNCVkeHUh?=
IST-SL1	M1S3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF6yb4NKSzVyPUCuOlA1OzVizszN	M3:wSHNCVkeHUh?=
NCI-H2126	MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoPqTWM2OD1yLk[zNVUzKM7:TR?=	NI\KRXZUSU6JRWK=
HCC1954	M{\U[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTBwNkS3NlYh\|ryP	MXPTRW5ITVJ?
WM-115	M3fyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{T4c2lEPTB;MD62OVA6OiEQvF2=	NELHOlJUSU6JRWK=
NB6	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDPTYRKSzVyPUCuOlc{OzVizszN	NFmxWFVUSU6JRWK=
TYK-nu	NF71N2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTBwNke5OVIh\|ryP	M3v1WHNCVkeHUh?=
KY821	MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTzTWM2OD1yLkewNlI6KM7:TR?=	M3\BOHNCVkeHUh?=
SIMA	M3uyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;qZmlEPTB;MD63NVcyQSEQvF2=	NV;iTm1UW0GQR1XS
RCC10RGB	M3nmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmm1TWM2OD1yLkexPVE5KM7:TR?=	MUTTRW5ITVJ?
LN-405	NU\Oco1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XkO2lEPTB;MD63OFM3KM7:TR?=	Ml\3V2FPT0WU
NCI-H1155	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEnkTmFKSzVyPUCuO\|Q5PjhizszN	NIntUXpUSU6JRWK=
SCLC-21H	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUD3dmN{UUN3ME2wMlc3QTB\|IN88US=>	NVL2b5ltW0GQR1XS
DMS-79	M2Hu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlvXTWM2OD1yLke3PFQ2KM7:TR?=	NVL0S\|hTW0GQR1XS
EC-GI-10	MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkTyTWM2OD1yLke3PVc2KM7:TR?=	NE\YZ\|JUSU6JRWK=
KNS-42	M{H2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\WNGpkUUN3ME2wMlc5QDNzIN88US=>	NGTC[pNUSU6JRWK=
SNU-475	NVTLfXltT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIS0WmxKSzVyPUCuO\|kzODJizszN	NFq4PGpUSU6JRWK=
SF539	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2PEOGlEPTB;MD63PVkzPSEQvF2=	M2nQcHNCVkeHUh?=
SW1417	M1Px[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fIeWlEPTB;MD64NVM{QSEQvF2=	M17Rb3NCVkeHUh?=
ATN-1	MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nLT2lEPTB;MD64OVEyPSEQvF2=	NILiXWtUSU6JRWK=
PLC-PRF-5	NEPCenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2jDbGlEPTB;MD64PFQ4PSEQvF2=	NV7mboVCW0GQR1XS
HT-3	M2n3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjLbZZjUUN3ME2wMlg6PDJizszN	M4nRdnNCVkeHUh?=
MDA-MB-453	M4TiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEPiflZKSzVyPUCuPVA{ODRizszN	NX6xW2FsW0GQR1XS
HAL-01	MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkCzTWM2OD1yLkm5N\|c6KM7:TR?=	M4Xu[HNCVkeHUh?=
NCI-H1993	NGHmZ\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2DuXGlEPTB;MT6wOFY2PyEQvF2=	MXvTRW5ITVJ?
NCI-H2227	NYDQdIt4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVWxdI9TUUN3ME2xMlA1QThzIN88US=>	NYDYNnNYW0GQR1XS
LP-1	NHPtbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTFwME[5N{DPxE1?	NEfLfZhUSU6JRWK=
P31-FUJ	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULuclJ6UUN3ME2xMlExPzZ4IN88US=>	MkTjV2FPT0WU
NCI-H64	M3LTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX\JR\|UxRTFwMUW0NkDPxE1?	MXTTRW5ITVJ?
SW1463	NEX1cWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXLOUZJRUUN3ME2xMlE5OzR7IN88US=>	MoTvV2FPT0WU
SK-MEL-1	MnizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTFwMkC1PVUh\|ryP	M1qzOXNCVkeHUh?=
TALL-1	M1jhNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4DiVWlEPTB;MT6yOVE3PSEQvF2=	M3\YPHNCVkeHUh?=
RO82-W-1	NUHRZnJKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4PIfGlEPTB;MT6zN\|M{QSEQvF2=	MlPVV2FPT0WU
NCI-H1581	M3KzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3:0PGlEPTB;MT6zOVY5PyEQvF2=	M3jZcHNCVkeHUh?=
NCI-H748	NFnHSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYTJR\|UxRTFwM{W3N\|gh\|ryP	MWjTRW5ITVJ?
HCC1187	MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHUN4w2UUN3ME2xMlU2PTJ{IN88US=>	MoDSV2FPT0WU
EoL-1-cell	MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml;ZTWM2OD1zLkW4PFg6KM7:TR?=	MXfTRW5ITVJ?
HuO-3N1	NUW2Zo1GT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;XTWM2OD1zLkizOFEzKM7:TR?=	NUXz[\|JHW0GQR1XS
NCI-H1793	NFi1[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mkn6TWM2OD1zLki3OVk{KM7:TR?=	NXPHZ\|VKW0GQR1XS
Caov-3	MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DtOWlEPTB;Mj6wNFYzPSEQvF2=	M1;h[HNCVkeHUh?=
JAR	NE\FSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHIWpJ6UUN3ME2yMlA4QTJizszN	NYjpR2tqW0GQR1XS
SK-MEL-28	NFnNeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkKyTWM2OD1{LkG4NFk5KM7:TR?=	MYDTRW5ITVJ?
EM-2	NI[xdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\RenNEUUN3ME2yMlIxOjl\|IN88US=>	MYjTRW5ITVJ?
Mewo	NV70dFhuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\LeWlEPTB;Mj6yNlI3PSEQvF2=	M2DZVnNCVkeHUh?=
NCI-H720	NHfLN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX6xTVBQUUN3ME2yMlI3PTh3IN88US=>	M1y0[nNCVkeHUh?=
CAL-54	M4r6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XpRWlEPTB;Mj6yOlc6PSEQvF2=	NXK0bXV2W0GQR1XS
MC116	M2\heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4SzeWlEPTB;Mj6zOlM6PyEQvF2=	NFezSYxUSU6JRWK=
DG-75	NF7yXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jqb2lEPTB;Mj60PFU4PiEQvF2=	NUOxdFJWW0GQR1XS
HCC1143	NFW2OmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWD1XY81UUN3ME2yMlUxPjV6IN88US=>	MlPYV2FPT0WU
FTC-133	NHf1SZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4fJVmlEPTB;Mj61N\|Y5QSEQvF2=	M3nyS3NCVkeHUh?=
AsPC-1	MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\FeGNKSzVyPUKuOVM6OjlizszN	M2DlNXNCVkeHUh?=
NCI-H889	MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfaVWZmUUN3ME2yMlU3PzB4IN88US=>	Ml7YV2FPT0WU
HT55	MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\HTWM2OD1{Lk[yNFE6KM7:TR?=	NX3XenF4W0GQR1XS
UMC-11	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLETWM2OD1{Lke4O\|E2KM7:TR?=	M1TiT3NCVkeHUh?=
P12-ICHIKAWA	MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nuZWlEPTB;Mj64NlA1PiEQvF2=	MmjrV2FPT0WU
HCC1395	M1njSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nGRmlEPTB;Mj65PFYxOiEQvF2=	NW\YOlFVW0GQR1XS
D-283MED	NGftfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTNwMUi5N\|ch\|ryP	MkHaV2FPT0WU
COLO-800	M2DtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEj3OGZKSzVyPUOuN\|M5QTdizszN	M{\UVXNCVkeHUh?=
MFM-223	NUDMcZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXXJR\|UxRTNwM{[wPVch\|ryP	M4jzSHNCVkeHUh?=
TE-5	NGf4OpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3LyfGlEPTB;ND61OlE1PyEQvF2=	MVrTRW5ITVJ?
NCI-H209	NFTzbWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTRwN{i1O\|Ih\|ryP	MWrTRW5ITVJ?
SiHa	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nz[GlEPTB;ND65OVIxOyEQvF2=	M4jHe3NCVkeHUh?=
NCI-H1395	MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWjJR\|UxRTVwMUC2N\|Mh\|ryP	NGS1N3NUSU6JRWK=
A498	MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFG3NJpKSzVyPUWuNlEzPTFizszN	NFvpPXBUSU6JRWK=
ES5	M2T3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LRfGlEPTB;NT62NVE4QCEQvF2=	NYnlSZVLW0GQR1XS
MDA-MB-157	NX7MW2NOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7Eb4M2UUN3ME21MlY3PDR\|IN88US=>	M4fP[3NCVkeHUh?=
NCI-H1623	NIPJNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFrGb2ZKSzVyPUWuPFM2PTZizszN	M2H0fXNCVkeHUh?=
RPMI-8866	MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2fxUmlEPTB;NT64OFc6OiEQvF2=	MXHTRW5ITVJ?
LC-1F	NFfLPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlThTWM2OD14LkC5NlkyKM7:TR?=	NW\6S3MxW0GQR1XS
TCCSUP	M2jqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnq0TWM2OD14Lk[wN\|Q6KM7:TR?=	NUm4b2d4W0GQR1XS
TT	MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUS2bXU3UUN3ME24MlM{ODB7IN88US=>	NXLEU5hHW0GQR1XS
NCI-H1838	NXnkV2hXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDNTWM2OD16LkWxO\|MyKM7:TR?=	NHL2d\|dUSU6JRWK=
NCI-H322M	MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG\UeW1KSzVyPUmuNVYzQDFizszN	NXflXJlwW0GQR1XS
NCI-H187	NEX5T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTlwNUG4N\|Uh\|ryP	MXHTRW5ITVJ?
SBC-1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml70TWM2OD17LkmzOlU3KM7:TR?=	MYHTRW5ITVJ?
SCC-3	M1TucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIezO3ZKSzVyPUGwMlU3PzlizszN	NEDkeotUSU6JRWK=
SW948	MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXe3dWdzUUN3ME2xNE44PTFzIN88US=>	MlLIV2FPT0WU
CPC-N	M{LiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NU[2NoluUUN3ME2xNU4xODdizszN	M3ThVHNCVkeHUh?=
TGBC24TKB	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFPWNWNKSzVyPUGzMlUzQSEQvF2=	M{X0fXNCVkeHUh?=
NCI-H2452	M{WxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknITWM2OD1zND63N{DPxE1?	NYTwSIljW0GQR1XS
Hs-578-T	MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITq[XlKSzVyPUG4MlU4PTlizszN	M{ntNHNCVkeHUh?=
DV-90	MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFj0VldKSzVyPUG4Mlk6PDVizszN	MX7TRW5ITVJ?
NCI-H1563	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fESmlEPTB;MUmuO\|g5QCEQvF2=	NXPxNZJDW0GQR1XS
SW780	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPZWoV[UUN3ME2yNU4yOzF6IN88US=>	NUjBco9VW0GQR1XS
NCI-H345	M1naWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfVdIFKSzVyPUKxMlg4PzlizszN	M1zwN3NCVkeHUh?=
LB771-HNC	M{HaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIXLcllKSzVyPUKyMlQ5OTNizszN	NYrCfWNmW0GQR1XS
RT4	NV7OVWN4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2TubmlEPTB;MkOuN\|I5OiEQvF2=	M2jLNXNCVkeHUh?=
NCI-H82	NHvPb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXPGfFVpUUN3ME2yN{42PTJ4IN88US=>	M1TRNnNCVkeHUh?=
NCI-H524	NEfQW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rkRWlEPTB;MkSuN\|gyOiEQvF2=	M1TMenNCVkeHUh?=
SNU-C1	Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnnHTWM2OD1{ND65NVA2KM7:TR?=	MnTyV2FPT0WU
NCI-SNU-16	MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmD4TWM2OD12OD6zNVQzKM7:TR?=	NVvM[ZNYW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; PubMed: 23993685 Mol Oncol Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein. E-cadherin / Cleaved PARP / Bim; PubMed: 23993685 Mol Oncol Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein. HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; PubMed: 24796583 Oncotarget CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control. CDK4 / HMGA2 ; PubMed: 26893968 PeerJ HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.	23993685 24796583 26893968
Growth inhibition assay	Cell viability; PubMed: 26893968 PeerJ Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. p < 0.05, p < 0.01, **p < 0.001. All experiments were performed in three independent experiments.	26893968

In vivo

Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. ^[2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. ^[3]

Protocol

Kinase Assay:^[3]	- Collapse Kinase assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:^[1]	- Collapse Cell lines: Human gastric cancer cells NCI-N87 Concentrations: 1 μM Incubation Time: 3 days Method: Human gastric cancer cells NCI-N87 (5-7 ×10³ in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Animal Research:^[3]	- Collapse Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts Formulation: In DMSO and diluted in sterile saline/Tween 20 Dosages: 50 mg/kg Administration: Administered via i.v. or i.p. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL warmed (199.76 mM)
	Ethanol	31 mg/mL (66.58 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 1% DMSO+30% polyethylene glycol+1% Tween 80 For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Molecular Weight	465.54
Formula	C₂₆H₃₁N₃O₅
CAS No.	747412-49-3
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	VER-52296

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01772797	Completed	Drug: LDK378\|Drug: AUY922	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Drug: AUY922	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Drug: AUY922\|Drug: BYL719	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1
NCT01484860	Terminated	Drug: AUY922	Adenocarcinoma of the Pancreas\|Metastatic Disease	University Health Network Toronto\|Novartis Pharmaceuticals	January 2012	Phase 2
NCT01402401	Terminated	Drug: AUY922 + Trastuzumab	Advanced Gastric Cancer	Novartis Pharmaceuticals\|Novartis	November 2011	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Related HSP (e.g. HSP90) Products

PU-H71 ^New

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437 ^New

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
VER155008 ^New

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Features:Displays very low toxicity toward normal cells.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.
Elesclomol (STA-4783)

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Onalespib (AT13387)

Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 47 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products

Choose Your Country or Region

By Signaling Pathways

By product type

Luminespib (AUY-922, NVP-AUY922)

Cited by 47 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Luminespib (AUY-922, NVP-AUY922) SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

Tech Support

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

Related HSP (e.g. HSP90) Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)