Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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Cited by 30 Publications

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD1TWM2OD1yLkCwNFEzPSEQvF2= NWDvZm15W0GQR1XS
MV-4-11 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO4TWM2OD1yLkCwNFU2QCEQvF2= MXnTRW5ITVJ?
NALM-6 NYfkOpYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTvTWM2OD1yLkCwNFg1OiEQvF2= MonWV2FPT0WU
HOS M3jtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMECxN|gh|ryP MmrtV2FPT0WU
HT-144 NF21PYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMECxOVUh|ryP MYXTRW5ITVJ?
SW1710 NEnySpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HdmJKSzVyPUCuNFAyQDZizszN MlnkV2FPT0WU
TE-8 NGOybZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrxTWM2OD1yLkCwNlM4KM7:TR?= NH\m[HlUSU6JRWK=
ES1 NFH3clVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\uTVJiUUN3ME2wMlAxOjZ4IN88US=> NVP6bINtW0GQR1XS
CCF-STTG1 NX\Je284T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3pTWM2OD1yLkCwNlk4KM7:TR?= NFjRc3JUSU6JRWK=
PSN1 NUPr[VBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zTeGlEPTB;MD6wNFMyQCEQvF2= MYjTRW5ITVJ?
CAL-51 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnPTWM2OD1yLkCwN|I2KM7:TR?= MUnTRW5ITVJ?
MCF7 NXHkNWkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMECzN|Uh|ryP NFmyXo9USU6JRWK=
SK-HEP-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECzN|Yh|ryP MXjTRW5ITVJ?
LCLC-103H NF;GRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEC0N{DPxE1? NIjBNWNUSU6JRWK=
HMV-II M3\4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\TSW1{UUN3ME2wMlAxPDR7IN88US=> MmLBV2FPT0WU
MES-SA MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPwTWM2OD1yLkCwOFUzKM7:TR?= NFPVe2VUSU6JRWK=
SK-LMS-1 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;abWJKSzVyPUCuNFA1PThizszN MkDnV2FPT0WU
639-V M3qxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonuTWM2OD1yLkCwOFg2KM7:TR?= M2jDW3NCVkeHUh?=
SIG-M5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\1TWlEPTB;MD6wNFQ5QSEQvF2= Mlu2V2FPT0WU
LOUCY MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi1fFZKSzVyPUCuNFA2ODVizszN MkfXV2FPT0WU
HSC-2 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3HTWM2OD1yLkCwOVE5KM7:TR?= NFLneZhUSU6JRWK=
EW-13 M1S5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nac2lEPTB;MD6wNFUyQCEQvF2= MXTTRW5ITVJ?
RT-112 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLsTWM2OD1yLkCwOVM2KM7:TR?= MkjvV2FPT0WU
NKM-1 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\r[XVKUUN3ME2wMlAxPTR5IN88US=> MXzTRW5ITVJ?
KYSE-180 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfXTWM2OD1yLkCwOVg3KM7:TR?= MV;TRW5ITVJ?
SW1783 NIOzT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\DTWM2OD1yLkCwOVkyKM7:TR?= NIDmOWJUSU6JRWK=
A431 M{G5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLsTWM2OD1yLkCwOlA4KM7:TR?= MXvTRW5ITVJ?
SK-OV-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEC2N{DPxE1? NF7xdXBUSU6JRWK=
RPMI-7951 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHXTWM2OD1yLkCwOlMyKM7:TR?= NFLjc21USU6JRWK=
Capan-2 NYD4Zod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TYPGlEPTB;MD6wNFY{QCEQvF2= MVnTRW5ITVJ?
HSC-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nZUGlEPTB;MD6wNFY1OSEQvF2= MVrTRW5ITVJ?
786-0 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzwSm1KSzVyPUCuNFA3PjNizszN M3HJZ3NCVkeHUh?=
Daoy M3ri[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEC2PVUh|ryP NGnJNFhUSU6JRWK=
KGN NUXBXVdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTVTWM2OD1yLkCwO|A{KM7:TR?= NYqyd|Z7W0GQR1XS
EW-16 NWT5eog4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DPOGlEPTB;MD6wNFc1QSEQvF2= M1\vSHNCVkeHUh?=
EW-7 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrKTWM2OD1yLkCwO|U1KM7:TR?= NIfRXm1USU6JRWK=
IGROV-1 M3PJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS4TWM2OD1yLkCwPFE1KM7:TR?= M2PKW3NCVkeHUh?=
8505C M{HEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEC4NlEh|ryP NFfCO21USU6JRWK=
RKO M{XkXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW2WG1KSzVyPUCuNFA5OjZizszN MVvTRW5ITVJ?
GDM-1 NEjrdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrlTWM2OD1yLkCwPFQh|ryP M{fpdXNCVkeHUh?=
IST-MEL1 NFvtbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDSUHRKSzVyPUCuNFA5PTJizszN NVvHd2pyW0GQR1XS
RPMI-6666 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEC4OVIh|ryP MlTJV2FPT0WU
SNG-M MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEC4OVYh|ryP NVflOmdLW0GQR1XS
KS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEC4OVkh|ryP NXfMcFE1W0GQR1XS
RXF393 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrvcIRKSzVyPUCuNFA5PiEQvF2= M4\0bHNCVkeHUh?=
CAL-12T NEfCeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jxdmlEPTB;MD6wNFkzOiEQvF2= NEXPcpdUSU6JRWK=
BFTC-905 NVrEenlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEC5N|gh|ryP MmXwV2FPT0WU
SK-MES-1 NHP5TmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;oSVFyUUN3ME2wMlAxQTR3IN88US=> NUfNXXFWW0GQR1XS
BB30-HNC NUKy[JExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[3TWM2OD1yLkCwPVUzKM7:TR?= MmLNV2FPT0WU
AN3-CA NFfjU4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH3b|FNUUN3ME2wMlAyODF5IN88US=> M3;oRXNCVkeHUh?=
EFO-27 MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XHNmlEPTB;MD6wNVAyPyEQvF2= MYPTRW5ITVJ?
G-401 NUixfHl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEGwNlUh|ryP MYHTRW5ITVJ?
BPH-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEGwN{DPxE1? MY\TRW5ITVJ?
NCI-H727 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrTN|lKSzVyPUCuNFExOyEQvF2= M3La[nNCVkeHUh?=
SNU-423 NEPRSVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEGwOVMh|ryP M1Xa[3NCVkeHUh?=
KYSE-270 NEPlW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEGwOVkh|ryP NUn6ZnlVW0GQR1XS
AGS NIPQNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTlTWM2OD1yLkCxNFYyKM7:TR?= M3m0T3NCVkeHUh?=
NCI-H2228 M3jZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEGwOlQh|ryP M4T0cXNCVkeHUh?=
SW954 M3LNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\hTWM2OD1yLkCxNFcyKM7:TR?= MlTMV2FPT0WU
769-P NUnBV5JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnoeWExUUN3ME2wMlAyODd|IN88US=> Mn3JV2FPT0WU
BB49-HNC NWTx[5RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXeze5VkUUN3ME2wMlAyODd5IN88US=> MoXTV2FPT0WU
IA-LM NIHrWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW2TWM2OD1yLkCxNFg3KM7:TR?= M1\uTXNCVkeHUh?=
NB69 NXTEVVZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fuU2lEPTB;MD6wNVExOiEQvF2= M17DXnNCVkeHUh?=
C8166 Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO0bXlKSzVyPUCuNFEyOjlizszN NWDkfmQyW0GQR1XS
NCI-H1299 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnsToVTUUN3ME2wMlAyOTV2IN88US=> M{TIPXNCVkeHUh?=
YKG-1 NXXOVWc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH2VoFjUUN3ME2wMlAyOTZizszN NFjJU5ZUSU6JRWK=
PANC-03-27 M{jlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MornTWM2OD1yLkCxNVYzKM7:TR?= M3rTbXNCVkeHUh?=
YT MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;CTWM2OD1yLkCxNVc6KM7:TR?= NUTtTpVnW0GQR1XS
CAL-85-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml2wTWM2OD1yLkCxNVkzKM7:TR?= MUnTRW5ITVJ?
GT3TKB M1:z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfLWoFKSzVyPUCuNFEzODJizszN MmWyV2FPT0WU
BB65-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTBTWM2OD1yLkCxNlA1KM7:TR?= NHjER2hUSU6JRWK=
ES6 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEGyOlEh|ryP MoXRV2FPT0WU
MHH-ES-1 MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILmR5lKSzVyPUCuNFEzPjNizszN MVTTRW5ITVJ?
QIMR-WIL M3z0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fXXWlEPTB;MD6wNVI3QSEQvF2= MX;TRW5ITVJ?
SNU-C2B NGTUfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rROGlEPTB;MD6wNVI4OiEQvF2= MXzTRW5ITVJ?
OCI-AML2 NWHMb4dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEGyPFEh|ryP NXS3fGlIW0GQR1XS
DU-145 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;uTWM2OD1yLkCxNlkh|ryP M4jwZ3NCVkeHUh?=
SW982 M3fZc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\oTmxKUUN3ME2wMlAyOjl|IN88US=> MVTTRW5ITVJ?
MFH-ino NV\reXk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL0W3dKSzVyPUCuNFEzQTNizszN NEXuc5BUSU6JRWK=
A427 MlrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDtTWM2OD1yLkCxNlk6KM7:TR?= MYHTRW5ITVJ?
LCLC-97TM1 M3myfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEGzJO69VQ>? MmPZV2FPT0WU
AM-38 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn6SI9vUUN3ME2wMlAyOzB{IN88US=> NULNeHlMW0GQR1XS
K5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[yWXZKSzVyPUCuNFE{ODhizszN NILz[mlUSU6JRWK=
T84 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHxTWM2OD1yLkCxN|MyKM7:TR?= M3TnPXNCVkeHUh?=
TE-15 MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGzT5dHUUN3ME2wMlAyOzN4IN88US=> MX\TRW5ITVJ?
NCI-H460 NV;CZlBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEGzN|Yh|ryP NELpSWlUSU6JRWK=
NTERA-S-cl-D1 NWTYV|ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEGzN|kh|ryP NHLQTpJUSU6JRWK=
KYSE-450 M2LrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmiwTWM2OD1yLkCxN|Q6KM7:TR?= NFXNfpdUSU6JRWK=
H4 M3u4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEGzOlYh|ryP M3ThNnNCVkeHUh?=
LC-2-ad NIDsWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTY[odxUUN3ME2wMlAyOzdizszN MUnTRW5ITVJ?
GAMG NI\V[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEGzO|Eh|ryP M3jEb3NCVkeHUh?=
TK10 NHv3c|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TuVmlEPTB;MD6wNVM5OiEQvF2= MX7TRW5ITVJ?
NCI-H2122 NW\jVHkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnxNpZKSzVyPUCuNFE{QDRizszN M3vFbHNCVkeHUh?=
KM12 NXvqeJNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEGzPVkh|ryP MYnTRW5ITVJ?
CAL-39 NWOxXG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSzTWM2OD1yLkCxOFIh|ryP NXzNN|Y3W0GQR1XS
RPMI-2650 NEOwWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7PTWM2OD1yLkCxOFMzKM7:TR?= MULTRW5ITVJ?
KYSE-510 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\sTWM2OD1yLkCxOFQzKM7:TR?= M3S2eHNCVkeHUh?=
KALS-1 M1HiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUniZ5BbUUN3ME2wMlAyPDZ4IN88US=> NVnzNGRoW0GQR1XS
NCI-H1648 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DkS2lEPTB;MD6wNVQ6QSEQvF2= NGG4d3RUSU6JRWK=
ES4 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEG1NFIh|ryP MmTIV2FPT0WU
C-33-A MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEG1NFkh|ryP NXXEPFJSW0GQR1XS
MIA-PaCa-2 M4rZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEG1NFkh|ryP MX3TRW5ITVJ?
Becker MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfScmRKSzVyPUCuNFE2OTRizszN M3X3RnNCVkeHUh?=
HOP-62 M2rjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEG1OFIh|ryP M4SzPHNCVkeHUh?=
TE-1 MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjW[INKSzVyPUCuNFE2QDFizszN NUTkd4hZW0GQR1XS
KYSE-410 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHzTWM2OD1yLkCxOVg3KM7:TR?= MkfyV2FPT0WU
NOS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfEZnFKSzVyPUCuNFE2QTNizszN NFXvV|BUSU6JRWK=
MEL-HO NIHvepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEG2OFMh|ryP MVnTRW5ITVJ?
NCI-H1650 M3TxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWzenBlUUN3ME2wMlAyPjR4IN88US=> MkW1V2FPT0WU
VMRC-RCZ MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHHTWM2OD1yLkCxOlUyKM7:TR?= NV;CUIw4W0GQR1XS
HuP-T3 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG1TWM2OD1yLkCxOlU{KM7:TR?= M1PHVHNCVkeHUh?=
ACN MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rjUmlEPTB;MD6wNVY2PyEQvF2= M4e4[XNCVkeHUh?=
MEL-JUSO NHji[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j2cWlEPTB;MD6wNVY5OSEQvF2= MVnTRW5ITVJ?
HT-1197 NVO5SHpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\mbnFKSzVyPUCuNFE3QDVizszN M4PTZXNCVkeHUh?=
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SF268 M{LZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXOSVNxUUN3ME2wMlA{PDBzIN88US=> MoXWV2FPT0WU
BV-173 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT0OWlJUUN3ME2wMlA{PDJ4IN88US=> NVTNRY1YW0GQR1XS
DMS-273 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEO0O|kh|ryP NIjSVWFUSU6JRWK=
22RV1 M3O4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDNTWM2OD1yLkCzOVA4KM7:TR?= NHvzS29USU6JRWK=
ES8 NYSwOYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfiT3Z2UUN3ME2wMlA{PTN6IN88US=> NI\a[G1USU6JRWK=
KYSE-150 NW[xZYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEizOXpKSzVyPUCuNFM3ODhizszN M3n2XHNCVkeHUh?=
HCC1569 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEO2NFgh|ryP MkL0V2FPT0WU
NB5 NW[5O|E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L2UGlEPTB;MD6wN|YyOyEQvF2= MWjTRW5ITVJ?
G-402 M2fieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPjb2ZtUUN3ME2wMlA{PjF2IN88US=> M3PyeXNCVkeHUh?=
NCI-H1693 NYnye4ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEO2NVch|ryP NUKwVGc4W0GQR1XS
LB2241-RCC MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnWSI1xUUN3ME2wMlA{PjR{IN88US=> NFTqTGNUSU6JRWK=
KP-4 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnxNGJKSzVyPUCuNFM3PjNizszN NF7Y[VFUSU6JRWK=
ML-2 M3TJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;R[lRKSzVyPUCuNFM3PzFizszN Mn:3V2FPT0WU
KU812 NEPxeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjNOVlKSzVyPUCuNFM3QDRizszN MnP3V2FPT0WU
LS-411N NYO0dGl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfQTFF3UUN3ME2wMlA{PzNzIN88US=> MULTRW5ITVJ?
OAW-42 M4TwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TTRmlEPTB;MD6wN|c1PyEQvF2= MkC2V2FPT0WU
HCC38 NUHzVYxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T0OmlEPTB;MD6wN|c4OSEQvF2= NXr6PGlVW0GQR1XS
Ca-Ski M3u2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvTcIZKSzVyPUCuNFM4QDRizszN M4\Hd3NCVkeHUh?=
Calu-3 NYjIPHI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnpdmprUUN3ME2wMlA{Pzh7IN88US=> NIPB[HRUSU6JRWK=
KYSE-70 NF32NZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnF[JpKSzVyPUCuNFM5OTJizszN NV;zblhJW0GQR1XS
D-392MG Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEO4OFIh|ryP MYHTRW5ITVJ?
OVCAR-4 M2\Z[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXpTWM2OD1yLkCzPFU5KM7:TR?= MXzTRW5ITVJ?
Detroit562 NH3EbXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz6TWM2OD1yLkCzPFczKM7:TR?= M1vDe3NCVkeHUh?=
HEL NIj4[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;q[|lKSzVyPUCuNFM5QTFizszN MoLJV2FPT0WU
MONO-MAC-6 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEO4PVMh|ryP M1fQ[HNCVkeHUh?=
LoVo NIT5XIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr0S2ZpUUN3ME2wMlA{QTN|IN88US=> NFzj[GVUSU6JRWK=
U-2-OS Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:1eGVKSzVyPUCuNFM6OzVizszN MlixV2FPT0WU
A172 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33PfWlEPTB;MD6wN|k2KM7:TR?= NWf0OmVPW0GQR1XS
OCUB-M NYjxNmRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7TWHhKSzVyPUCuNFM6PjFizszN M2fGbXNCVkeHUh?=
SW48 M{LhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHjXIZKSzVyPUCuNFQxOzFizszN Ml[4V2FPT0WU
HC-1 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTzTWM2OD1yLkC0NFY6KM7:TR?= Ml7QV2FPT0WU
KOSC-2 NULKUY42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMESxNUDPxE1? NVzubHRLW0GQR1XS
HDLM-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHTOmdzUUN3ME2wMlA1OTF2IN88US=> MXzTRW5ITVJ?
CTV-1 NFiyO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMESxNVYh|ryP NY\hWFAyW0GQR1XS
SH-4 NH3YRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrOeG9OUUN3ME2wMlA1OTRzIN88US=> MojNV2FPT0WU
SW756 M4XZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMESxOVch|ryP MXjTRW5ITVJ?
GCT MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HmcGlEPTB;MD6wOFE3OSEQvF2= Mm\5V2FPT0WU
CHL-1 NX65NGZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfZOpFPUUN3ME2wMlA1OTZ7IN88US=> MnPXV2FPT0WU
LAMA-84 M1\iN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHj[m9KSzVyPUCuNFQyPzFizszN MoG2V2FPT0WU
LS-1034 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr5dZhKSzVyPUCuNFQyQTFizszN NX3EbW9yW0GQR1XS
NCI-H358 NGHpOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfUfFBKSzVyPUCuNFQzOTJizszN M4PKOXNCVkeHUh?=
NB13 NU\nO4V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\mUXVrUUN3ME2wMlA1OjJ5IN88US=> NUXTUGM2W0GQR1XS
TE-9 NUDYeG9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PRW2lEPTB;MD6wOFI{PyEQvF2= MkfhV2FPT0WU
OE33 M2\LbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jGT2lEPTB;MD6wOFI1OSEQvF2= MYLTRW5ITVJ?
CAL-120 NFi4WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXHWFhKSzVyPUCuNFQzPDFizszN MnjLV2FPT0WU
DJM-1 MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn3cJhEUUN3ME2wMlA1Ojd{IN88US=> NW\ORXNOW0GQR1XS
SK-MEL-24 NVzBXY5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Ozb2lEPTB;MD6wOFI5OyEQvF2= M1;xU3NCVkeHUh?=
VA-ES-BJ Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMESyPVIh|ryP MWXTRW5ITVJ?
MMAC-SF NVPoS|k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nDTWlEPTB;MD6wOFI6PyEQvF2= NFPOS3FUSU6JRWK=
MZ7-mel NFHSW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M175OmlEPTB;MD6wOFM{KM7:TR?= M2GxT3NCVkeHUh?=
BxPC-3 NWixboVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DqS2lEPTB;MD6wOFM1OSEQvF2= Mof2V2FPT0WU
HT-29 NVWxfHBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwcmlEPTB;MD6wOFM2PyEQvF2= M3S0VHNCVkeHUh?=
SK-MEL-30 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnUcoJKSzVyPUCuNFQ{PjJizszN MoXlV2FPT0WU
CAL-33 M2fWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17pU2lEPTB;MD6wOFM4PSEQvF2= M2nubXNCVkeHUh?=
COLO-680N MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMES0NFch|ryP MoG5V2FPT0WU
NH-12 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvITWM2OD1yLkC0OFQh|ryP M4rub3NCVkeHUh?=
HCC1937 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMES0OVYh|ryP MX7TRW5ITVJ?
IMR-5 MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPQUZVFUUN3ME2wMlA1PDlizszN M1:zb3NCVkeHUh?=
MC-CAR MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e3bWlEPTB;MD6wOFU3QSEQvF2= NXvlN|NvW0GQR1XS
NCI-H747 MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\qW4FKSzVyPUCuNFQ2PyEQvF2= MXnTRW5ITVJ?
NCI-H1792 NFH5TlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL2RoVKSzVyPUCuNFQ2QDFizszN MUPTRW5ITVJ?
SW13 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nIN2lEPTB;MD6wOFU6KM7:TR?= M1njcHNCVkeHUh?=
MLMA NWPFb4ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOyWohKSzVyPUCuNFQ3ODlizszN Mnn2V2FPT0WU
U251 NGLMVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMES3OlMh|ryP M2nNeXNCVkeHUh?=
U031 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fXNmlEPTB;MD6wOFc4OSEQvF2= NWjzd3doW0GQR1XS
ME-180 NGPkZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vCUmlEPTB;MD6wOFc5OiEQvF2= NFjkTmJUSU6JRWK=
SK-MEL-3 M1HHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMES4NFIh|ryP MYTTRW5ITVJ?
MOLT-4 NVnrN2xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHmTWM2OD1yLkC0PFA{KM7:TR?= M1n3cXNCVkeHUh?=
PF-382 M4XJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33We2lEPTB;MD6wOFgzPiEQvF2= M3G1THNCVkeHUh?=
NUGC-3 M4LrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L0cmlEPTB;MD6wOFgzPyEQvF2= NELpN3NUSU6JRWK=
NCI-H1417 NF;ZW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rVd2lEPTB;MD6wOFg6KM7:TR?= Ml30V2FPT0WU
COLO-205 NXq3OZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq5U5VKSzVyPUCuNFQ6OTlizszN NV\XOWFsW0GQR1XS
TE-441-T M3:0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMES5N{DPxE1? MnzHV2FPT0WU
MKN1 M{HDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMES5N{DPxE1? MmLwV2FPT0WU
UM-UC-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMES5OUDPxE1? M1v1bXNCVkeHUh?=
SF126 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu4e3NxUUN3ME2wMlA2ODFizszN NUC4[XNqW0GQR1XS
LB1047-RCC MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEWwN|Eh|ryP MnLVV2FPT0WU
A253 M4\IXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzkTWM2OD1yLkC1NFUzKM7:TR?= MULTRW5ITVJ?
NCI-H1963 M2jBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP4b4JKSzVyPUCuNFUyPzZizszN M2DINnNCVkeHUh?=
VM-CUB-1 NHPMcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEWzNVEh|ryP MkLiV2FPT0WU
T-24 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPXTWM2OD1yLkC1N|g1KM7:TR?= M1;udXNCVkeHUh?=
K-562 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfWTWM2OD1yLkC1N|g4KM7:TR?= MXvTRW5ITVJ?
ARH-77 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEWzPVUh|ryP MYPTRW5ITVJ?
CA46 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlexTWM2OD1yLkC1OFMh|ryP MYLTRW5ITVJ?
HCC70 NVjGR49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W4eGlEPTB;MD6wOVQ2OiEQvF2= NH;pOppUSU6JRWK=
ST486 NFXuOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W1OmlEPTB;MD6wOVUzPSEQvF2= MoTiV2FPT0WU
COLO-741 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TTZmlEPTB;MD6wOVU{OSEQvF2= M17LenNCVkeHUh?=
SK-PN-DW M3\Pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fCVGlEPTB;MD6wOVU5QCEQvF2= M4XKZXNCVkeHUh?=
BL-41 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M333eWlEPTB;MD6wOVU6PiEQvF2= M2Hnc3NCVkeHUh?=
D-263MG MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zDVWlEPTB;MD6wOVY5OyEQvF2= MoHJV2FPT0WU
KE-37 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPLU5B2UUN3ME2wMlA2Pjh|IN88US=> NV\GN4FEW0GQR1XS
LU-134-A NXq0[plHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEW3NVUh|ryP MXHTRW5ITVJ?
HCC2157 NYe3NVF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq2VnFWUUN3ME2wMlA2PzN|IN88US=> NHf6bXJUSU6JRWK=
GAK MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEW3N|Qh|ryP NFX5bG9USU6JRWK=
IST-SL2 NIL1c4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrMW2ptUUN3ME2wMlA2PzR|IN88US=> NVPTW2dOW0GQR1XS
KMOE-2 NWLlNY11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEW3OFkh|ryP M2q5VXNCVkeHUh?=
SW1573 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEW4NFIh|ryP MX7TRW5ITVJ?
SCC-9 M1\oZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGzNpJKSzVyPUCuNFU5PyEQvF2= M2XWWHNCVkeHUh?=
MDA-MB-361 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fWO2lEPTB;MD6wOVg4OiEQvF2= Ml3VV2FPT0WU
BHT-101 NHXp[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTFTWM2OD1yLkC1PFc3KM7:TR?= MWXTRW5ITVJ?
NCI-H1770 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjKbWtKSzVyPUCuNFU5PzlizszN M3HhdXNCVkeHUh?=
UACC-893 NGHj[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PkUGlEPTB;MD6wOVg6PiEQvF2= MofLV2FPT0WU
NCI-H226 M3z5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrqXIh3UUN3ME2wMlA2QTh6IN88US=> NGfwd5lUSU6JRWK=
HLE MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIntZWlKSzVyPUCuNFYxQDJizszN NWPtO4M4W0GQR1XS
NCI-H1703 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXmXWhKSzVyPUCuNFYyPzhizszN NVXNNY5DW0GQR1XS
KURAMOCHI M4\0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fQ[2lEPTB;MD6wOlE5QSEQvF2= M{\aUHNCVkeHUh?=
RH-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[2XWlEPTB;MD6wOlI{KM7:TR?= M{PvTXNCVkeHUh?=
DSH1 Ml7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnLdoZKSzVyPUCuNFYzPyEQvF2= MYXTRW5ITVJ?
CAMA-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwME[zNFMh|ryP NIXzSpNUSU6JRWK=
NCI-H1437 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPq[4VKSzVyPUCuNFY{OjhizszN MmPNV2FPT0WU
HuP-T4 M3PWO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwME[1PFYh|ryP NGPZe2NUSU6JRWK=
HCT-15 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7qWYxMUUN3ME2wMlA3PTl5IN88US=> M4HQfHNCVkeHUh?=
NCCIT NEDvSnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXDTWM2OD1yLkC2OlA1KM7:TR?= NHq3Ro9USU6JRWK=
BOKU NWHDeWZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3XTWM2OD1yLkC2Olc1KM7:TR?= M2j3XnNCVkeHUh?=
FADU MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvoTWM2OD1yLkC2O|Q2KM7:TR?= MmqxV2FPT0WU
SUP-T1 M2HmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7FTWM2OD1yLkC2O|Yh|ryP NEXzZ29USU6JRWK=
L-363 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwME[5NFEh|ryP NW\1XWJEW0GQR1XS
KNS-81-FD MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLlTWM2OD1yLkC2PVE5KM7:TR?= NI[wPHJUSU6JRWK=
SU-DHL-1 M2ro[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLmeYRxUUN3ME2wMlA3QTJizszN M{DoRXNCVkeHUh?=
HuH-7 NI\6ZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTPd3hOUUN3ME2wMlA4ODN3IN88US=> NW\EXJFEW0GQR1XS
BT-474 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLtTWM2OD1yLkC3NFYyKM7:TR?= MkfYV2FPT0WU
CAPAN-1 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfrTWM2OD1yLkC3NVQ{KM7:TR?= MlS0V2FPT0WU
HEC-1 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnDZoNKSzVyPUCuNFcyPjFizszN NHX5N2lUSU6JRWK=
NOMO-1 NH;jbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPrTWM2OD1yLkC3NVczKM7:TR?= MoKyV2FPT0WU
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SK-N-DZ NHnGeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfveWxKSzVyPUCuNVc5QDNizszN NH64c3lUSU6JRWK=
EGI-1 NYfRbpFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLlTWM2OD1yLkG3PVch|ryP NWHCPZpHW0GQR1XS
COLO-320-HSR MkfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPpcllKSzVyPUCuNVg1QTNizszN MoHSV2FPT0WU
DOHH-2 NHnzWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX3clZCUUN3ME2wMlE5PTZ7IN88US=> M2ixXnNCVkeHUh?=
MS-1 M4nISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrUTWM2OD1yLkG4OkDPxE1? NYr5Nm1QW0GQR1XS
NCI-H2171 M4TsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfxTnJVUUN3ME2wMlE5PjR7IN88US=> Ml3DV2FPT0WU
NCI-H526 NHvXV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\SenZKSzVyPUCuNVg3QTZizszN NYfTOVhRW0GQR1XS
MDA-MB-415 NHfVNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2zTWM2OD1yLkG5O|Q5KM7:TR?= NYn0[|lPW0GQR1XS
ECC4 MkXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Lrc2lEPTB;MD6xPVg3OyEQvF2= NGL5OGNUSU6JRWK=
C2BBe1 NHfJOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr6elNKSzVyPUCuNVk5QTNizszN MXvTRW5ITVJ?
TE-11 NIjoWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXuWIFKSzVyPUCuNVk6PzVizszN MXXTRW5ITVJ?
LU-65 NHf3VmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMkCyNVEh|ryP NHTxW3JUSU6JRWK=
MKN45 NHXxb5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e4OWlEPTB;MD6yNFY1KM7:TR?= M2rBdnNCVkeHUh?=
TGBC1TKB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXYZYtEUUN3ME2wMlIxQTl5IN88US=> MXTTRW5ITVJ?
NCI-H2196 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMkG3OFch|ryP M3v6[XNCVkeHUh?=
M14 NI[yTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLKTWM2OD1yLkKxPFA{KM7:TR?= M1nrUHNCVkeHUh?=
NCI-H1436 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnDfJNKSzVyPUCuNlE5OjZizszN MnnTV2FPT0WU
EB-3 NVTIN45yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nyO2lEPTB;MD6yNlM4PiEQvF2= MV;TRW5ITVJ?
HT NW\mcmpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVizRppMUUN3ME2wMlIzPTZ4IN88US=> MkH6V2FPT0WU
A3-KAW NUfCeVJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GzUGlEPTB;MD6yNlcxQCEQvF2= MXzTRW5ITVJ?
DB NY\2U4h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf5TWM2OD1yLkKyPFY2KM7:TR?= M17sWHNCVkeHUh?=
KARPAS-299 NE[5b4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\QXWc2UUN3ME2wMlIzQTl2IN88US=> NVfWZnRoW0GQR1XS
IM-9 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPKTWM2OD1yLkKzOFc3KM7:TR?= MXPTRW5ITVJ?
NCI-H838 M2XLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXPTJJKSzVyPUCuNlM4OTRizszN MlrsV2FPT0WU
NB10 NYnWNZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUThO5VQUUN3ME2wMlI{PzNzIN88US=> NGHBfpVUSU6JRWK=
NCI-H2141 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn1TWM2OD1yLkKzPFQyKM7:TR?= NWDtdnpKW0GQR1XS
LB647-SCLC MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH2dG5KSzVyPUCuNlQxOTRizszN NUjRSpp7W0GQR1XS
NCI-H23 NHfSR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPRR|B1UUN3ME2wMlI1ODV7IN88US=> MoDmV2FPT0WU
MN-60 M4PRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPk[I1KSzVyPUCuNlQzOzlizszN NUnRe4I{W0GQR1XS
CAL-148 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7XTWM2OD1yLkK0NlgzKM7:TR?= NGLCXFdUSU6JRWK=
EFE-184 M2HGSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMkS1PVch|ryP NUT6folUW0GQR1XS
TE-6 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMkS2NVIh|ryP M4rkenNCVkeHUh?=
SN12C M2ntNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLBTWM2OD1yLkK0Olk1KM7:TR?= M4n3fHNCVkeHUh?=
CAKI-1 M13XfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\iOYVKSzVyPUCuNlUxQDZizszN NVjOSFREW0GQR1XS
MHH-NB-11 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTiTWM2OD1yLkK1N|Uh|ryP M{Xy[nNCVkeHUh?=
DOK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHnbmpxUUN3ME2wMlI2QTNizszN MV3TRW5ITVJ?
Raji MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP5dZk1UUN3ME2wMlI3PjB|IN88US=> M3;P[3NCVkeHUh?=
OAW-28 M{m0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr2TWM2OD1yLkK2Olc4KM7:TR?= NVe0V5NwW0GQR1XS
P30-OHK NFzN[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rIbmlEPTB;MD6yOlkxPSEQvF2= Mnj1V2FPT0WU
NCI-H69 NGroUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMkeyNFEh|ryP Ml7rV2FPT0WU
SK-N-AS M1PmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fye2lEPTB;MD6yO|IzKM7:TR?= MlLMV2FPT0WU
BE-13 NVqwXHVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TSNWlEPTB;MD6yO|I1QSEQvF2= NGPvV45USU6JRWK=
NCI-H1618 NIXpflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK2XWhKSzVyPUCuNlc2OSEQvF2= MVHTRW5ITVJ?
NCI-SNU-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMke2NVMh|ryP MUjTRW5ITVJ?
NCI-H1694 NH\kcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMke3N|Mh|ryP NVnIPFQ{W0GQR1XS
RL NFHBeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrwTWM2OD1yLkK4NVc1KM7:TR?= MX;TRW5ITVJ?
SW684 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfIdoRnUUN3ME2wMlI5Ozh|IN88US=> M4H4VnNCVkeHUh?=
EW-24 M3\4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULW[pFkUUN3ME2wMlI5QDFizszN NWHWZ5UyW0GQR1XS
NCI-H510A NIjUPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMkmzNFQh|ryP MoTiV2FPT0WU
Mo-T M4j6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrsfGRnUUN3ME2wMlI6OzNzIN88US=> M2nOfXNCVkeHUh?=
LB373-MEL-D NXv6b2toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMkm0N|Eh|ryP MojWV2FPT0WU
NCI-H28 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLQVmVKSzVyPUCuNlk5OzdizszN NX7uUJF6W0GQR1XS
NCI-H446 NHmzVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXoc2lKSzVyPUCuNlk6OjFizszN MV\TRW5ITVJ?
L-540 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrJeplKSzVyPUCuN|AxQDlizszN MnTLV2FPT0WU
MKN7 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M130ZWlEPTB;MD6zNFY{QSEQvF2= NX7vdVNNW0GQR1XS
OPM-2 NF\R[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwM{GwOlQh|ryP MmPJV2FPT0WU
BT-20 NUG5XVVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nKXWlEPTB;MD6zNVA6QSEQvF2= MnnyV2FPT0WU
KP-N-YN NVPIXFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\FcVZpUUN3ME2wMlMyOTF6IN88US=> M4PQZ3NCVkeHUh?=
MDA-MB-175-VII NUTxWFF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwM{KzOFgh|ryP M2iybnNCVkeHUh?=
EFM-19 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e0NGlEPTB;MD6zN|E{OiEQvF2= NHOzUHVUSU6JRWK=
COLO-678 M2\mZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHizOYxKSzVyPUCuN|M{QDlizszN MVLTRW5ITVJ?
COLO-829 NXnvOmZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\lTWM2OD1yLkO0OFUzKM7:TR?= MXrTRW5ITVJ?
A704 NHS1cXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S2NGlEPTB;MD6zOFkzOyEQvF2= MnrzV2FPT0WU
NCI-H719 NGHZU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwM{WxNlQh|ryP NXTKfohMW0GQR1XS
MFE-280 M2jGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXKUWxIUUN3ME2wMlM2PzF3IN88US=> MYjTRW5ITVJ?
DMS-114 NXnNc2Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHe5N5ZKSzVyPUCuN|YyOiEQvF2= M3:3ZnNCVkeHUh?=
RMG-I MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwM{[2PVEh|ryP MkD5V2FPT0WU
SK-N-FI MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfi[HBKSzVyPUCuN|c3OzdizszN MkDFV2FPT0WU
LB2518-MEL MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKzbXZKSzVyPUCuOFA5PzJizszN NXXtOGlwW0GQR1XS
IST-MES1 NFvuOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwNEGxJO69VQ>? NW\DfYlKW0GQR1XS
HPAF-II M17qT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTSUZBKSzVyPUCuOFEyOTdizszN M3fVZnNCVkeHUh?=
NCI-H1882 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn1SpFXUUN3ME2wMlQyPzh2IN88US=> MnTlV2FPT0WU
JVM-2 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHtTWM2OD1yLkS0OFAyKM7:TR?= NUKz[21TW0GQR1XS
T47D NX3rR2NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\oWnJKSzVyPUCuOFQ2OjhizszN M36yOnNCVkeHUh?=
MHH-CALL-2 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{juV2lEPTB;MD60OFg{KM7:TR?= MV\TRW5ITVJ?
NCI-H716 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr2UIJKSzVyPUCuOFQ5PDhizszN NYn2cXJkW0GQR1XS
NEC8 NHnSSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\D[3RCUUN3ME2wMlQ2OTR3IN88US=> NETFWm5USU6JRWK=
UACC-812 NYTObmhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\xTWM2OD1yLkS2O|c3KM7:TR?= MkTxV2FPT0WU
D-502MG NWTvSWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHG[2FKSzVyPUCuOFgxOyEQvF2= NEfkVoVUSU6JRWK=
CaR-1 M4rlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwNUCzOlch|ryP NH7mcotUSU6JRWK=
LU-139 NV22[4VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof3TWM2OD1yLkWxOFU4KM7:TR?= NE\ENVdUSU6JRWK=
RPMI-8402 M4X5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnUTWM2OD1yLkWyNlA4KM7:TR?= MYXTRW5ITVJ?
SW1088 M1LDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz1W5pKSzVyPUCuOVM5PjlizszN MmHHV2FPT0WU
JVM-3 M4PBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwNUSxNVch|ryP MofCV2FPT0WU
YAPC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLHc2xvUUN3ME2wMlU2OjFzIN88US=> M1vpNnNCVkeHUh?=
KG-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNUW5PFQh|ryP MVrTRW5ITVJ?
C32 M{SweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnLO|VKSzVyPUCuOVc{OTNizszN M{LofnNCVkeHUh?=
IST-SL1 NVrSUGVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv4TWM2OD1yLk[wOFM2KM7:TR?= NXPlb5A3W0GQR1XS
NCI-H2126 M1Lu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\HTmlEPTB;MD62N|E2OiEQvF2= NXHiUWN1W0GQR1XS
HCC1954 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j0cWlEPTB;MD62OFczPiEQvF2= M3\hc3NCVkeHUh?=
WM-115 M17iPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\3VmlEPTB;MD62OVA6OiEQvF2= Mmf5V2FPT0WU
NB6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\VUGtKSzVyPUCuOlc{OzVizszN MXPTRW5ITVJ?
TYK-nu MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf4flJNUUN3ME2wMlY4QTV{IN88US=> M{npbXNCVkeHUh?=
KY821 NVL5WFlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwN{CyNlkh|ryP MUjTRW5ITVJ?
SIMA NWqwSlVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwN{G3NVkh|ryP Mnn6V2FPT0WU
RCC10RGB NUL1NGo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS0RnlKSzVyPUCuO|E6OThizszN Ml;tV2FPT0WU
LN-405 NU\vb4doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmL0TWM2OD1yLke0N|Yh|ryP MVrTRW5ITVJ?
NCI-H1155 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjNeZVKUUN3ME2wMlc1QDZ6IN88US=> NF3lc2FUSU6JRWK=
SCLC-21H NYHScGdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVToO|ZwUUN3ME2wMlc3QTB|IN88US=> NYrE[nRkW0GQR1XS
DMS-79 M1HFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwN{e4OFUh|ryP MnzFV2FPT0WU
EC-GI-10 M{eyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH2SYNrUUN3ME2wMlc4QTd3IN88US=> NYLnOmlSW0GQR1XS
KNS-42 NV7NbWs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXQToNKSzVyPUCuO|g5OzFizszN NWnDR2xQW0GQR1XS
SNU-475 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq5dpBpUUN3ME2wMlc6OjB{IN88US=> NU\xdJR4W0GQR1XS
SF539 M3jMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfwcIlKSzVyPUCuO|k6OjVizszN NYPXfldVW0GQR1XS
SW1417 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP1SJc1UUN3ME2wMlgyOzN7IN88US=> MoT2V2FPT0WU
ATN-1 M2W3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP0TWM2OD1yLki1NVE2KM7:TR?= MVTTRW5ITVJ?
PLC-PRF-5 NXvCTo1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnkV4ppUUN3ME2wMlg5PDd3IN88US=> MXvTRW5ITVJ?
HT-3 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\1[lg{UUN3ME2wMlg6PDJizszN MXjTRW5ITVJ?
MDA-MB-453 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC0TWM2OD1yLkmwN|A1KM7:TR?= MljtV2FPT0WU
HAL-01 NYjSc3Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXyW2RKSzVyPUCuPVk{PzlizszN MmnvV2FPT0WU
NCI-H1993 NFnrO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\hZ|lKSzVyPUGuNFQ3PTdizszN M2LvXXNCVkeHUh?=
NCI-H2227 NIfFWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFwMES5PFEh|ryP Mln2V2FPT0WU
LP-1 M3;YW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTFwME[5N{DPxE1? NUns[VJQW0GQR1XS
P31-FUJ M4i2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXFTWM2OD1zLkGwO|Y3KM7:TR?= MmC1V2FPT0WU
NCI-H64 NUjSTW1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz6OW54UUN3ME2xMlE2PDJizszN MWTTRW5ITVJ?
SW1463 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvlTWM2OD1zLkG4N|Q6KM7:TR?= NXfQNJFwW0GQR1XS
SK-MEL-1 MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzsd2RUUUN3ME2xMlIxPTl3IN88US=> M2jzTnNCVkeHUh?=
TALL-1 NEnaPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5eYdIUUN3ME2xMlI2OTZ3IN88US=> M2LseHNCVkeHUh?=
RO82-W-1 NXz6UJpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDSbXJKSzVyPUGuN|M{OzlizszN MWnTRW5ITVJ?
NCI-H1581 NGjBN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnPV25KSzVyPUGuN|U3QDdizszN NV3RPXdFW0GQR1XS
NCI-H748 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzrTWM2OD1zLkO1O|M5KM7:TR?= NVzkU4Q6W0GQR1XS
HCC1187 M1jsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfyTWM2OD1zLkW1OVIzKM7:TR?= NG\LPZdUSU6JRWK=
EoL-1-cell NIf4Z5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFwNUi4PFkh|ryP M{TV[nNCVkeHUh?=
HuO-3N1 NX6wW4g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHnXIZKSzVyPUGuPFM1OTJizszN M2DJbnNCVkeHUh?=
NCI-H1793 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3BTWM2OD1zLki3OVk{KM7:TR?= MnLyV2FPT0WU
Caov-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnDR3FKSzVyPUKuNFA3OjVizszN MnnVV2FPT0WU
JAR NV3v[JJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLETWM2OD1{LkC3PVIh|ryP M3jJSXNCVkeHUh?=
SK-MEL-28 M17wN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJwMUiwPVgh|ryP NEH4e5hUSU6JRWK=
EM-2 NVf2elFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMkCyPVMh|ryP MlnoV2FPT0WU
Mewo MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\UTWM2OD1{LkKyNlY2KM7:TR?= MnfkV2FPT0WU
NCI-H720 M1raTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvrRWtTUUN3ME2yMlI3PTh3IN88US=> M4TwR3NCVkeHUh?=
CAL-54 NFy5c2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfmNoRKSzVyPUKuNlY4QTVizszN MU\TRW5ITVJ?
MC116 M1;xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwM{[zPVch|ryP Mk\5V2FPT0WU
DG-75 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PZR2lEPTB;Mj60PFU4PiEQvF2= NV76Z4lVW0GQR1XS
HCC1143 NWD6UXd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rBOGlEPTB;Mj61NFY2QCEQvF2= M3KwfXNCVkeHUh?=
FTC-133 NU\w[4JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\RTWM2OD1{LkWzOlg6KM7:TR?= M37nN3NCVkeHUh?=
AsPC-1 NYixUJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofZTWM2OD1{LkWzPVI6KM7:TR?= MXLTRW5ITVJ?
NCI-H889 M1f5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH2SYVKSzVyPUKuOVY4ODZizszN MlLXV2FPT0WU
HT55 M1rCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHOTWM2OD1{Lk[yNFE6KM7:TR?= NX;Fe4xSW0GQR1XS
UMC-11 NH;FSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XPWWlEPTB;Mj63PFcyPSEQvF2= M{njVHNCVkeHUh?=
P12-ICHIKAWA NGnNR3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[5e2lEPTB;Mj64NlA1PiEQvF2= NYjVUJE{W0GQR1XS
HCC1395 NIfqfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\jVG5GUUN3ME2yMlk5PjB{IN88US=> MlLtV2FPT0WU
D-283MED M3\UeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2zTWM2OD1|LkG4PVM4KM7:TR?= M4\WcXNCVkeHUh?=
COLO-800 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnYTWM2OD1|LkOzPFk4KM7:TR?= M4HIN3NCVkeHUh?=
MFM-223 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLtV5NKSzVyPUOuN|YxQTdizszN MX\TRW5ITVJ?
TE-5 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LsTmlEPTB;ND61OlE1PyEQvF2= NUHIR|R5W0GQR1XS
NCI-H209 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzrb5p5UUN3ME20Mlc5PTd{IN88US=> MYnTRW5ITVJ?
SiHa NVHJWVJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13K[2lEPTB;ND65OVIxOyEQvF2= M1vxSHNCVkeHUh?=
NCI-H1395 M4DKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfVTVlKSzVyPUWuNVA3OzNizszN NHPRT|BUSU6JRWK=
A498 NFjEVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwMkGyOVEh|ryP MoPNV2FPT0WU
ES5 M33JWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjmc3BJUUN3ME21MlYyOTd6IN88US=> MWjTRW5ITVJ?
MDA-MB-157 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTOTWM2OD13Lk[2OFQ{KM7:TR?= MoDOV2FPT0WU
NCI-H1623 NVzvT41YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LYdmlEPTB;NT64N|U2PiEQvF2= NYC1UnZmW0GQR1XS
RPMI-8866 NHjLfZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfETWM2OD13Lki0O|kzKM7:TR?= MmnLV2FPT0WU
LC-1F NHfWS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLxPIl5UUN3ME22MlA6OjlzIN88US=> NIHReXFUSU6JRWK=
TCCSUP M2nHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETFb5BKSzVyPU[uOlA{PDlizszN NGTl[4dUSU6JRWK=
TT MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG3W3hUUUN3ME24MlM{ODB7IN88US=> M1zwUnNCVkeHUh?=
NCI-H1838 M2\6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rrWGlEPTB;OD61NVc{OSEQvF2= M4S5VHNCVkeHUh?=
NCI-H322M M3fifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm4b5JKSzVyPUmuNVYzQDFizszN MY\TRW5ITVJ?
NCI-H187 M3:zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;DTWM2OD17LkWxPFM2KM7:TR?= M4HUdHNCVkeHUh?=
SBC-1 M4fpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK2TIlKSzVyPUmuPVM3PTZizszN M2DsPHNCVkeHUh?=
SCC-3 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXrTWM2OD1zMD61Olc6KM7:TR?= NEfFdohUSU6JRWK=
SW948 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;uTWM2OD1zMD63OVEyKM7:TR?= NGDC[WlUSU6JRWK=
CPC-N NUXIV3F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XKT2lEPTB;MUGuNFA4KM7:TR?= NWX2eo12W0GQR1XS
TGBC24TKB NFPRUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XPOGlEPTB;MUOuOVI6KM7:TR?= M1;3cnNCVkeHUh?=
NCI-H2452 NF3WVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn32TWM2OD1zND63N{DPxE1? M3y3eHNCVkeHUh?=
Hs-578-T NUP0V4I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF6LkW3OVkh|ryP NF\tfIhUSU6JRWK=
DV-90 NXLTR20yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3YbmtKSzVyPUG4Mlk6PDVizszN M1fjU3NCVkeHUh?=
NCI-H1563 NUHaO5VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjOV4syUUN3ME2xPU44QDh6IN88US=> NHTX[4pUSU6JRWK=
SW780 M37OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2dGxKSzVyPUKxMlE{OThizszN M3rNbXNCVkeHUh?=
NCI-H345 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTEbZhKSzVyPUKxMlg4PzlizszN NH\UWmhUSU6JRWK=
LB771-HNC NFLaW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ{LkS4NVMh|ryP NHrNZW5USU6JRWK=
RT4 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HSPWlEPTB;MkOuN|I5OiEQvF2= MWDTRW5ITVJ?
NCI-H82 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ|LkW1NlYh|ryP MlrQV2FPT0WU
NCI-H524 M12y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjGb4JCUUN3ME2yOE4{QDF{IN88US=> NWLXRnI2W0GQR1XS
SNU-C1 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJ2LkmxNFUh|ryP NVjrcFZNW0GQR1XS
NCI-SNU-16 NV7tdZBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDYb4FKSzVyPUS4MlMyPDJizszN MVPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID