Luminespib (NVP-AUY922)

For research use only.

Catalog No.S1069 Synonyms: AUY-922

67 publications

Luminespib (NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.

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Selleck's Luminespib (NVP-AUY922) has been cited by 67 publications

Purity & Quality Control

Choose Selective HSP (HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMECwNVI2KM7:TR?= MULTRW5ITVJ?
MV-4-11 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD1yLkCwNFU2QCEQvF2= Mm\UV2FPT0WU
NALM-6 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXUS4J5UUN3ME2wMlAxODh2MjFOwG0> M2O4bXNCVkeHUh?=
HOS MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DsZmlEPTB;MD6wNFE{QCEQvF2= MkD1V2FPT0WU
HT-144 MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HGeWlEPTB;MD6wNFE2PSEQvF2= MkO2V2FPT0WU
SW1710 M4[4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pv[GlEPTB;MD6wNFE5PiEQvF2= M1zYPXNCVkeHUh?=
TE-8 NYK1UFQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3pOnJKSzVyPUCuNFAzOzdizszN M3jTfXNCVkeHUh?=
ES1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rTPGlEPTB;MD6wNFI3PiEQvF2= NVTTVm85W0GQR1XS
CCF-STTG1 NH3EXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMECyPVch|ryP NUK0SZVoW0GQR1XS
PSN1 NF\1WnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;mTWM2OD1yLkCwN|E5KM7:TR?= MV3TRW5ITVJ?
CAL-51 M1fVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMECzNlUh|ryP MV7TRW5ITVJ?
MCF7 NILod|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7FdnRyUUN3ME2wMlAxOzN3IN88US=> MXXTRW5ITVJ?
SK-HEP-1 NWDNdW1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjnWJIyUUN3ME2wMlAxOzN4IN88US=> NHjOb25USU6JRWK=
LCLC-103H NGHOVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jL[WlEPTB;MD6wNFQ{KM7:TR?= M3viWXNCVkeHUh?=
HMV-II Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK1PFRqUUN3ME2wMlAxPDR7IN88US=> M1XTRXNCVkeHUh?=
MES-SA MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v5WWlEPTB;MD6wNFQ2OiEQvF2= M2nWcnNCVkeHUh?=
SK-LMS-1 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[xbldMUUN3ME2wMlAxPDV6IN88US=> NH;vSpFUSU6JRWK=
639-V Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\WWGlEPTB;MD6wNFQ5PSEQvF2= M1fnXXNCVkeHUh?=
SIG-M5 NYDRZWhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEC0PFkh|ryP MXXTRW5ITVJ?
LOUCY NVTtbJA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEC1NFUh|ryP MkLHV2FPT0WU
HSC-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjoUpJzUUN3ME2wMlAxPTF6IN88US=> NUDRcmpPW0GQR1XS
EW-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEC1NVgh|ryP M2S4SHNCVkeHUh?=
RT-112 NVWyfIdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnWNoNbUUN3ME2wMlAxPTN3IN88US=> Ml;MV2FPT0WU
NKM-1 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHaN3NKSzVyPUCuNFA2PDdizszN MlzXV2FPT0WU
KYSE-180 NH\pbFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XIVWlEPTB;MD6wNFU5PiEQvF2= NH7vU|ZUSU6JRWK=
SW1783 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLvU4ZzUUN3ME2wMlAxPTlzIN88US=> NH;GXo9USU6JRWK=
A431 NIPocWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfhXJEyUUN3ME2wMlAxPjB5IN88US=> MVHTRW5ITVJ?
SK-OV-3 NUjEdI9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEC2N{DPxE1? NEHt[VNUSU6JRWK=
RPMI-7951 NICyWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEC2N|Eh|ryP MX;TRW5ITVJ?
Capan-2 NGXiSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz0TnRKSzVyPUCuNFA3OzhizszN NXzGTnRZW0GQR1XS
HSC-3 NXjUcHV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLkTWM2OD1yLkCwOlQyKM7:TR?= MoruV2FPT0WU
786-0 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPmR|Y3UUN3ME2wMlAxPjZ|IN88US=> NUTOW4FOW0GQR1XS
Daoy NFq1[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvtfJlKSzVyPUCuNFA3QTVizszN NWnwfFFJW0GQR1XS
KGN M3rHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17wRmlEPTB;MD6wNFcxOyEQvF2= NFXHTVhUSU6JRWK=
EW-16 M3HhbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEC3OFkh|ryP M2PCUnNCVkeHUh?=
EW-7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;TZWlEPTB;MD6wNFc2PCEQvF2= Mlv4V2FPT0WU
IGROV-1 M3vIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnnTWM2OD1yLkCwPFE1KM7:TR?= NVLjNXNEW0GQR1XS
8505C MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEC4NlEh|ryP MlPRV2FPT0WU
RKO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PwXmlEPTB;MD6wNFgzPiEQvF2= M37FdHNCVkeHUh?=
GDM-1 M4H0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEC4OEDPxE1? M3nhcXNCVkeHUh?=
IST-MEL1 NUPRdY1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEC4OVIh|ryP MnHZV2FPT0WU
RPMI-6666 MlGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTXR4hKUUN3ME2wMlAxQDV{IN88US=> NYnDOog{W0GQR1XS
SNG-M M4\RUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrwdmZrUUN3ME2wMlAxQDV4IN88US=> MU\TRW5ITVJ?
KS-1 MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPDTWM2OD1yLkCwPFU6KM7:TR?= MWLTRW5ITVJ?
RXF393 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXDb4FKSzVyPUCuNFA5PiEQvF2= NGfRTJRUSU6JRWK=
CAL-12T NY\zOmtDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fEXmlEPTB;MD6wNFkzOiEQvF2= MmnSV2FPT0WU
BFTC-905 NH\iV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPURpNWUUN3ME2wMlAxQTN6IN88US=> MmjwV2FPT0WU
SK-MES-1 NYi5NWlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr0TWM2OD1yLkCwPVQ2KM7:TR?= NYLpdHZQW0GQR1XS
BB30-HNC NF\oelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7DZpBKSzVyPUCuNFA6PTJizszN NF;FTY1USU6JRWK=
AN3-CA M1jue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfvdnhKSzVyPUCuNFExOTdizszN NGrSUI1USU6JRWK=
EFO-27 NVnIclVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi3bJdDUUN3ME2wMlAyODF5IN88US=> M3nxU3NCVkeHUh?=
G-401 Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[2SGlEPTB;MD6wNVAzPSEQvF2= MnryV2FPT0WU
BPH-1 NEPLWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEGwN{DPxE1? M3TyNnNCVkeHUh?=
NCI-H727 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEGwN{DPxE1? Mn\tV2FPT0WU
SNU-423 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjWcVJKSzVyPUCuNFExPTNizszN NGnVfIpUSU6JRWK=
KYSE-270 NGrBSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\YdWhKSzVyPUCuNFExPTlizszN MmnoV2FPT0WU
AGS MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPKOJBKSzVyPUCuNFExPjFizszN MkO1V2FPT0WU
NCI-H2228 NHLpbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P2emlEPTB;MD6wNVA3PCEQvF2= NXntd403W0GQR1XS
SW954 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\TNmloUUN3ME2wMlAyODdzIN88US=> MlHKV2FPT0WU
769-P MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzsZ2RHUUN3ME2wMlAyODd|IN88US=> MXHTRW5ITVJ?
BB49-HNC MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonGTWM2OD1yLkCxNFc4KM7:TR?= NYjtR|dpW0GQR1XS
IA-LM MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEGwPFYh|ryP NVP6PZR1W0GQR1XS
NB69 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nqdWlEPTB;MD6wNVExOiEQvF2= MWjTRW5ITVJ?
C8166 M{\ETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P4OmlEPTB;MD6wNVEzQSEQvF2= NGrWR|JUSU6JRWK=
NCI-H1299 NEXse5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEGxOVQh|ryP NYjNTHhbW0GQR1XS
YKG-1 M2jYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEGxOkDPxE1? MVXTRW5ITVJ?
PANC-03-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fOSWlEPTB;MD6wNVE3OiEQvF2= NVGzZnZRW0GQR1XS
YT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7WS5hKSzVyPUCuNFEyPzlizszN MlHKV2FPT0WU
CAL-85-1 NWjOd5dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xSHVEUUN3ME2wMlAyOTl{IN88US=> NGn6PHhUSU6JRWK=
GT3TKB NFribGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPNTWM2OD1yLkCxNlAzKM7:TR?= M364enNCVkeHUh?=
BB65-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjjXW9KSzVyPUCuNFEzODRizszN M4nNVHNCVkeHUh?=
ES6 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDNeXhKSzVyPUCuNFEzPjFizszN MXPTRW5ITVJ?
MHH-ES-1 NGDhSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr2[2JKSzVyPUCuNFEzPjNizszN MXzTRW5ITVJ?
QIMR-WIL MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEGyOlkh|ryP MVXTRW5ITVJ?
SNU-C2B M4O3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\y[XBKSzVyPUCuNFEzPzJizszN NWLIdJN5W0GQR1XS
OCI-AML2 NWPXeVhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEGyPFEh|ryP NX\2PIZrW0GQR1XS
DU-145 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O0UmlEPTB;MD6wNVI6KM7:TR?= NFOxO3hUSU6JRWK=
SW982 M{HQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEGyPVMh|ryP M1;RWHNCVkeHUh?=
MFH-ino M{XKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEGyPVMh|ryP NVr1[2RuW0GQR1XS
A427 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\XZmlEPTB;MD6wNVI6QSEQvF2= NHr4OnNUSU6JRWK=
LCLC-97TM1 NHvtXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHQTWM2OD1yLkCxN{DPxE1? MkHSV2FPT0WU
AM-38 NF;UTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEGzNFIh|ryP Mk\EV2FPT0WU
K5 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEGzNFgh|ryP NGnRZ2hUSU6JRWK=
T84 NIXxcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX1TWM2OD1yLkCxN|MyKM7:TR?= M1fifXNCVkeHUh?=
TE-15 M4X3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXiTWM2OD1yLkCxN|M3KM7:TR?= MkTZV2FPT0WU
NCI-H460 NVP4fFBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEGzN|Yh|ryP NU\zPFA1W0GQR1XS
NTERA-S-cl-D1 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\QTWlEPTB;MD6wNVM{QSEQvF2= MYHTRW5ITVJ?
KYSE-450 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFT2ZZRKSzVyPUCuNFE{PDlizszN MlSzV2FPT0WU
H4 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrONog1UUN3ME2wMlAyOzZ4IN88US=> NFnPZYFUSU6JRWK=
LC-2-ad MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPET5pGUUN3ME2wMlAyOzdizszN NYm5ZXZiW0GQR1XS
GAMG NXjEOmxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe5RnZKSzVyPUCuNFE{PzFizszN MnnKV2FPT0WU
TK10 NFXBcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfMNZRKSzVyPUCuNFE{QDJizszN NXX0U3R{W0GQR1XS
NCI-H2122 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn2emZKSzVyPUCuNFE{QDRizszN M4fKR3NCVkeHUh?=
KM12 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPMS2F2UUN3ME2wMlAyOzl7IN88US=> MVHTRW5ITVJ?
CAL-39 MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm3dIZKSzVyPUCuNFE1OiEQvF2= M1u1VXNCVkeHUh?=
RPMI-2650 NGfsXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXLTWM2OD1yLkCxOFMzKM7:TR?= M2rP[XNCVkeHUh?=
KYSE-510 M2e1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHYTWM2OD1yLkCxOFQzKM7:TR?= MWDTRW5ITVJ?
KALS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEG0OlYh|ryP Mo\qV2FPT0WU
NCI-H1648 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17jTWlEPTB;MD6wNVQ6QSEQvF2= M161WnNCVkeHUh?=
ES4 M4ryeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTUcopKSzVyPUCuNFE2ODJizszN MYjTRW5ITVJ?
C-33-A M3TMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEG1NFkh|ryP NIHycWdUSU6JRWK=
MIA-PaCa-2 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPrNlFVUUN3ME2wMlAyPTB7IN88US=> MlHmV2FPT0WU
Becker M2\S[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml34TWM2OD1yLkCxOVE1KM7:TR?= MVXTRW5ITVJ?
HOP-62 M13JW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe2fZhKSzVyPUCuNFE2PDJizszN NFftSHNUSU6JRWK=
TE-1 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrRUGxCUUN3ME2wMlAyPThzIN88US=> NGP4bJRUSU6JRWK=
KYSE-410 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f6PWlEPTB;MD6wNVU5PiEQvF2= MXzTRW5ITVJ?
NOS-1 M33UUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLpXI9KSzVyPUCuNFE2QTNizszN NWL6bWk{W0GQR1XS
MEL-HO Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEG2OFMh|ryP MoXjV2FPT0WU
NCI-H1650 M3XzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTpZXNzUUN3ME2wMlAyPjR4IN88US=> NYXZ[GhWW0GQR1XS
VMRC-RCZ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nzeGlEPTB;MD6wNVY2OSEQvF2= NYPPeWhYW0GQR1XS
HuP-T3 M{nafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjmR2psUUN3ME2wMlAyPjV|IN88US=> M{nhT3NCVkeHUh?=
ACN MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LJbGlEPTB;MD6wNVY2PyEQvF2= NFSwNmxUSU6JRWK=
MEL-JUSO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC3TWM2OD1yLkCxOlgyKM7:TR?= Mkj6V2FPT0WU
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OS-RC-2 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEOzPVYh|ryP MoO1V2FPT0WU
SF268 MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDxTWM2OD1yLkCzOFAyKM7:TR?= NFLGN25USU6JRWK=
BV-173 M1L5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TmO2lEPTB;MD6wN|QzPiEQvF2= MlXwV2FPT0WU
DMS-273 M4DHbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q2SWlEPTB;MD6wN|Q4QSEQvF2= MVzTRW5ITVJ?
22RV1 NF:2OmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWwdG5KSzVyPUCuNFM2ODdizszN M1vpO3NCVkeHUh?=
ES8 M3jzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEO1N|gh|ryP MXHTRW5ITVJ?
KYSE-150 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEO2NFgh|ryP MVzTRW5ITVJ?
HCC1569 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS0TWM2OD1yLkCzOlA5KM7:TR?= MnLiV2FPT0WU
NB5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HkV2lEPTB;MD6wN|YyOyEQvF2= MWPTRW5ITVJ?
G-402 NUHLeo1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m1WGlEPTB;MD6wN|YyPCEQvF2= NUXo[XpuW0GQR1XS
NCI-H1693 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLjN4tKSzVyPUCuNFM3OTdizszN MmPoV2FPT0WU
LB2241-RCC MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO2OFIh|ryP NHfodpZUSU6JRWK=
KP-4 M{i5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVyz[4JHUUN3ME2wMlA{PjZ|IN88US=> M2P3cXNCVkeHUh?=
ML-2 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fiR2lEPTB;MD6wN|Y4OSEQvF2= MXfTRW5ITVJ?
KU812 NUCzbodIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXtR4M4UUN3ME2wMlA{Pjh2IN88US=> MYfTRW5ITVJ?
LS-411N MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIexXoNKSzVyPUCuNFM4OzFizszN M3\RenNCVkeHUh?=
OAW-42 NHLwVpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvOUIJOUUN3ME2wMlA{PzR5IN88US=> NIi2e2xUSU6JRWK=
HCC38 NW\xT4xTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDTfJdKSzVyPUCuNFM4PzFizszN MljSV2FPT0WU
Ca-Ski MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HEd2lEPTB;MD6wN|c5PCEQvF2= M3jienNCVkeHUh?=
Calu-3 NIrXfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO3PFkh|ryP NEjjR4lUSU6JRWK=
KYSE-70 NHz0NYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHkTWM2OD1yLkCzPFEzKM7:TR?= NUS0c2hTW0GQR1XS
D-392MG NX:3RnBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEO4OFIh|ryP NGn6TVFUSU6JRWK=
OVCAR-4 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvDVHhKSzVyPUCuNFM5PThizszN NEnScY5USU6JRWK=
Detroit562 NGfuU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKzTWM2OD1yLkCzPFczKM7:TR?= MVPTRW5ITVJ?
HEL MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrmTWM2OD1yLkCzPFkyKM7:TR?= NEfKbJVUSU6JRWK=
MONO-MAC-6 NWfR[ZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\MTWM2OD1yLkCzPFk{KM7:TR?= NXvGPFZ7W0GQR1XS
LoVo NVqxWJRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13QPWlEPTB;MD6wN|k{OyEQvF2= NYnVNIF1W0GQR1XS
U-2-OS MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEO5N|Uh|ryP NHTVW2tUSU6JRWK=
A172 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvlS49KSzVyPUCuNFM6PSEQvF2= NFvmRmJUSU6JRWK=
OCUB-M MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGyTWM2OD1yLkCzPVYyKM7:TR?= NWDI[4VIW0GQR1XS
SW48 NG\ve|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG2SYpKSzVyPUCuNFQxOzFizszN NUDOVI9PW0GQR1XS
HC-1 M{nPOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP4[5BKSzVyPUCuNFQxPjlizszN NEfmUXVUSU6JRWK=
KOSC-2 M4C3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTu[WtVUUN3ME2wMlA1OTFizszN NYDn[ZNFW0GQR1XS
HDLM-2 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMESxNVQh|ryP MVnTRW5ITVJ?
CTV-1 NH3WSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HYemlEPTB;MD6wOFEyPiEQvF2= M1n0WnNCVkeHUh?=
SH-4 NXTRb4pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHYTWM2OD1yLkC0NVQyKM7:TR?= NYDQfVVnW0GQR1XS
SW756 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrkcVNKSzVyPUCuNFQyPTdizszN NW\wTJlLW0GQR1XS
GCT M3f4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMESxOlEh|ryP M2T0TnNCVkeHUh?=
CHL-1 M4HWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEizVmVKSzVyPUCuNFQyPjlizszN NYPiOGVnW0GQR1XS
LAMA-84 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojlTWM2OD1yLkC0NVcyKM7:TR?= M2LaWHNCVkeHUh?=
LS-1034 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHm[|FKSzVyPUCuNFQyQTFizszN NFPleGhUSU6JRWK=
NCI-H358 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMESyNVIh|ryP MV;TRW5ITVJ?
NB13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHDWnFEUUN3ME2wMlA1OjJ5IN88US=> NXfWNZd[W0GQR1XS
TE-9 NGqzcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LJeWlEPTB;MD6wOFI{PyEQvF2= MlLzV2FPT0WU
OE33 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL6OXJvUUN3ME2wMlA1OjRzIN88US=> MWPTRW5ITVJ?
CAL-120 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZTWM2OD1yLkC0NlQyKM7:TR?= M3e4UHNCVkeHUh?=
DJM-1 M{nHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u4NGlEPTB;MD6wOFI4OiEQvF2= MXPTRW5ITVJ?
SK-MEL-24 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK3RVhKSzVyPUCuNFQzQDNizszN MUPTRW5ITVJ?
VA-ES-BJ NXrZ[FBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMESyPVIh|ryP MXrTRW5ITVJ?
MMAC-SF NUWySmtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDWTWM2OD1yLkC0Nlk4KM7:TR?= NV7j[os6W0GQR1XS
MZ7-mel MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMESzN{DPxE1? NULE[3JSW0GQR1XS
BxPC-3 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D5TWlEPTB;MD6wOFM1OSEQvF2= MoD0V2FPT0WU
HT-29 Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\ZVGlEPTB;MD6wOFM2PyEQvF2= NIr6ZVNUSU6JRWK=
SK-MEL-30 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzlTWM2OD1yLkC0N|YzKM7:TR?= MVjTRW5ITVJ?
CAL-33 M1rWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTRTWM2OD1yLkC0N|c2KM7:TR?= M2XlU3NCVkeHUh?=
COLO-680N M133Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMES0NFch|ryP NI\mXYVUSU6JRWK=
NH-12 NGDmcohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmy[JVKSzVyPUCuNFQ1PCEQvF2= NWf6W3JoW0GQR1XS
HCC1937 NGjxfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHieGNKSzVyPUCuNFQ1PTZizszN MnL1V2FPT0WU
IMR-5 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTxTIJKSzVyPUCuNFQ1QSEQvF2= M{\qUHNCVkeHUh?=
MC-CAR NEfqWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zo[WlEPTB;MD6wOFU3QSEQvF2= MlnxV2FPT0WU
NCI-H747 NWHBWHVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3XTWM2OD1yLkC0OVch|ryP NX;se4w4W0GQR1XS
NCI-H1792 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml63TWM2OD1yLkC0OVgyKM7:TR?= NYDWTWpXW0GQR1XS
SW13 NG\LbnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[zO2lEPTB;MD6wOFU6KM7:TR?= M1TRbXNCVkeHUh?=
MLMA M2HtXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMES2NFkh|ryP M2\G[nNCVkeHUh?=
U251 M3;nPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMES3OlMh|ryP NF3WcJlUSU6JRWK=
U031 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DScWlEPTB;MD6wOFc4OSEQvF2= NHPRbIxUSU6JRWK=
ME-180 M3XSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrqPJJKSzVyPUCuNFQ4QDJizszN NWLxPYtKW0GQR1XS
SK-MEL-3 M{DxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMES4NFIh|ryP M{jzdHNCVkeHUh?=
MOLT-4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLq[4tKSzVyPUCuNFQ5ODNizszN MYHTRW5ITVJ?
PF-382 NWHVSoo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3UTWM2OD1yLkC0PFI3KM7:TR?= NEXVTXNUSU6JRWK=
NUGC-3 NFf5TolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\ENFFOUUN3ME2wMlA1QDJ5IN88US=> MWPTRW5ITVJ?
NCI-H1417 NVewNlZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXmNYVqUUN3ME2wMlA1QDlizszN MljIV2FPT0WU
COLO-205 M3zQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTjOmZbUUN3ME2wMlA1QTF7IN88US=> MX3TRW5ITVJ?
TE-441-T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPNTWM2OD1yLkC0PVMh|ryP MkjHV2FPT0WU
MKN1 M2S2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFWFhKSzVyPUCuNFQ6OyEQvF2= M2fqPXNCVkeHUh?=
UM-UC-3 Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr3TWM2OD1yLkC0PVUh|ryP MnPiV2FPT0WU
SF126 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj3[5ZKSzVyPUCuNFUxOSEQvF2= NGXJWmxUSU6JRWK=
LB1047-RCC M3HETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEWwN|Eh|ryP NVTReVlLW0GQR1XS
A253 M3jX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnZOnByUUN3ME2wMlA2ODV{IN88US=> NVToOZAxW0GQR1XS
NCI-H1963 M4DwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEWxO|Yh|ryP MXvTRW5ITVJ?
VM-CUB-1 NYK5SoM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\HUoRvUUN3ME2wMlA2OzFzIN88US=> NHv5dmVUSU6JRWK=
T-24 M3fYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Sc2JoUUN3ME2wMlA2Ozh2IN88US=> MYrTRW5ITVJ?
K-562 M1flbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDCU5RNUUN3ME2wMlA2Ozh5IN88US=> MUPTRW5ITVJ?
ARH-77 NXHpWZhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrJNXNKSzVyPUCuNFU{QTVizszN NHjVVHlUSU6JRWK=
CA46 NFPOSHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZeGlEPTB;MD6wOVQ{KM7:TR?= MU\TRW5ITVJ?
HCC70 NInlT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEW0OVIh|ryP MV3TRW5ITVJ?
ST486 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHlUlFKSzVyPUCuNFU2OjVizszN NYTwNIRtW0GQR1XS
COLO-741 NFP2XYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVOyRmltUUN3ME2wMlA2PTNzIN88US=> MXPTRW5ITVJ?
SK-PN-DW NV7xT2hjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPO[opSUUN3ME2wMlA2PTh6IN88US=> MWDTRW5ITVJ?
BL-41 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEW1PVYh|ryP M{LRbXNCVkeHUh?=
D-263MG NWq3[lJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzxe3hXUUN3ME2wMlA2Pjh|IN88US=> NWLVfIJsW0GQR1XS
KE-37 NGTUdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxS2JKSzVyPUCuNFU3QDNizszN MlPLV2FPT0WU
LU-134-A NUPlZZE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrOTWM2OD1yLkC1O|E2KM7:TR?= MluxV2FPT0WU
HCC2157 Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPIRWhKSzVyPUCuNFU4OzNizszN NUfpbmVWW0GQR1XS
GAK MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTrTWM2OD1yLkC1O|M1KM7:TR?= MlTFV2FPT0WU
IST-SL2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7kSFhKSzVyPUCuNFU4PDNizszN NVO4NlJVW0GQR1XS
KMOE-2 NUfNOXJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorFTWM2OD1yLkC1O|Q6KM7:TR?= NVnEeG1CW0GQR1XS
SW1573 NEL0PWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvHZ45KSzVyPUCuNFU5ODJizszN MlrQV2FPT0WU
SCC-9 NETINmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLzcVVbUUN3ME2wMlA2QDdizszN NXjLNXczW0GQR1XS
MDA-MB-361 M2nEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEW4O|Ih|ryP MnexV2FPT0WU
BHT-101 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDESpdKSzVyPUCuNFU5PzZizszN NVSyTmRMW0GQR1XS
NCI-H1770 NYLjRVBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEW4O|kh|ryP MU\TRW5ITVJ?
UACC-893 NUHzZ4RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzmWpBKSzVyPUCuNFU5QTZizszN M4HabXNCVkeHUh?=
NCI-H226 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEW5PFgh|ryP MVjTRW5ITVJ?
HLE M3u4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwME[wPFIh|ryP MYDTRW5ITVJ?
NCI-H1703 NH7nSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HueWlEPTB;MD6wOlE4QCEQvF2= Mn3rV2FPT0WU
KURAMOCHI MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K4[2lEPTB;MD6wOlE5QSEQvF2= NX73enBIW0GQR1XS
RH-1 NIG1W3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK3TWM2OD1yLkC2NlMh|ryP MVzTRW5ITVJ?
DSH1 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwME[yO{DPxE1? MYHTRW5ITVJ?
CAMA-1 NID2ZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e5PWlEPTB;MD6wOlMxOyEQvF2= MlHrV2FPT0WU
NCI-H1437 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT6[WQ5UUN3ME2wMlA3OzJ6IN88US=> M4TiRnNCVkeHUh?=
HuP-T4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nrPWlEPTB;MD6wOlU5PiEQvF2= NUTadFdZW0GQR1XS
HCT-15 NXjKRmhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7QNmhKSzVyPUCuNFY2QTdizszN NGnKdFJUSU6JRWK=
NCCIT NXu1fnhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;wXGlEPTB;MD6wOlYxPCEQvF2= NHT5bYdUSU6JRWK=
BOKU MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXTXmNKSzVyPUCuNFY3PzRizszN M3[xS3NCVkeHUh?=
FADU MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSydYlKSzVyPUCuNFY4PDVizszN M3PxbXNCVkeHUh?=
SUP-T1 M4q1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzQTWM2OD1yLkC2O|Yh|ryP M4OwTXNCVkeHUh?=
L-363 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwME[5NFEh|ryP NGjsO|JUSU6JRWK=
KNS-81-FD M17t[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjwTWM2OD1yLkC2PVE5KM7:TR?= MYnTRW5ITVJ?
SU-DHL-1 NYfMTXNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH5ZY4yUUN3ME2wMlA3QTJizszN M3jwWnNCVkeHUh?=
HuH-7 MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEewN|Uh|ryP M{DsdHNCVkeHUh?=
BT-474 M4LnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTiTWM2OD1yLkC3NFYyKM7:TR?= NUD1cVI4W0GQR1XS
CAPAN-1 NXy0elk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL5TWM2OD1yLkC3NVQ{KM7:TR?= MlO2V2FPT0WU
HEC-1 NHvNVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEexOlEh|ryP NGC2UllUSU6JRWK=
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HCC1187 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfwbVY5UUN3ME2xMlU2PTJ{IN88US=> M1\mV3NCVkeHUh?=
EoL-1-cell M{flTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDSNXJKSzVyPUGuOVg5QDlizszN NYH0TYRpW0GQR1XS
HuO-3N1 NWjCXY46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Lwd2lEPTB;MT64N|QyOiEQvF2= M3TK[3NCVkeHUh?=
NCI-H1793 NV;pTVlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDxSWhKSzVyPUGuPFc2QTNizszN NXLxbIk3W0GQR1XS
Caov-3 M{LWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fDfmlEPTB;Mj6wNFYzPSEQvF2= NFTlTllUSU6JRWK=
JAR NWnjXnlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjDTFlKSzVyPUKuNFc6OiEQvF2= M4H4WnNCVkeHUh?=
SK-MEL-28 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HEPWlEPTB;Mj6xPFA6QCEQvF2= MnrGV2FPT0WU
EM-2 NH3INGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJwMkCyPVMh|ryP MU\TRW5ITVJ?
Mewo M1fCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jGXmlEPTB;Mj6yNlI3PSEQvF2= M17xXnNCVkeHUh?=
NCI-H720 MnTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn4d4N1UUN3ME2yMlI3PTh3IN88US=> M4PiTXNCVkeHUh?=
CAL-54 MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;T[GY{UUN3ME2yMlI3Pzl3IN88US=> MljIV2FPT0WU
MC116 M1zLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrCTWM2OD1{LkO2N|k4KM7:TR?= NHHKZ41USU6JRWK=
DG-75 M2LKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPmOFh2UUN3ME2yMlQ5PTd4IN88US=> NF;aUIZUSU6JRWK=
HCC1143 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DjVGlEPTB;Mj61NFY2QCEQvF2= NYXVT5FKW0GQR1XS
FTC-133 NHvwdpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTCTWM2OD1{LkWzOlg6KM7:TR?= MnvKV2FPT0WU
AsPC-1 M1fINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTDdGUzUUN3ME2yMlU{QTJ7IN88US=> MYTTRW5ITVJ?
NCI-H889 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XhWGlEPTB;Mj61OlcxPiEQvF2= NEi3TJRUSU6JRWK=
HT55 M3;4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfmdnpKSzVyPUKuOlIxOTlizszN MkLDV2FPT0WU
UMC-11 NIf4WlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\kWo5sUUN3ME2yMlc5PzF3IN88US=> NEnGWmFUSU6JRWK=
P12-ICHIKAWA MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXLWlJKSzVyPUKuPFIxPDZizszN M4TxcHNCVkeHUh?=
HCC1395 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr6NYNKSzVyPUKuPVg3ODJizszN NXe1O5RHW0GQR1XS
D-283MED M1XjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCzRZhKSzVyPUOuNVg6OzdizszN MnvQV2FPT0WU
COLO-800 NFnkcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu0OnZKSzVyPUOuN|M5QTdizszN MoLNV2FPT0WU
MFM-223 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomyTWM2OD1|LkO2NFk4KM7:TR?= M{LDXHNCVkeHUh?=
TE-5 M1zxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;PdnVKSzVyPUSuOVYyPDdizszN NYPkZ4J6W0GQR1XS
NCI-H209 MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rhU2lEPTB;ND63PFU4OiEQvF2= M2TwfXNCVkeHUh?=
SiHa MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzHd5RYUUN3ME20Mlk2OjB|IN88US=> M4XNN3NCVkeHUh?=
NCI-H1395 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonVTWM2OD13LkGwOlM{KM7:TR?= NXrYWpFLW0GQR1XS
A498 NW\RbFJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HQ[GlEPTB;NT6yNVI2OSEQvF2= NETMWWFUSU6JRWK=
ES5 M1[5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO5eIxKSzVyPUWuOlEyPzhizszN NXjy[mI1W0GQR1XS
MDA-MB-157 MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTVwNk[0OFMh|ryP NIXIS2hUSU6JRWK=
NCI-H1623 NVfJS2FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm0V2ZFUUN3ME21Mlg{PTV4IN88US=> MU\TRW5ITVJ?
RPMI-8866 NVG1NolnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3IUWFKSzVyPUWuPFQ4QTJizszN MkW2V2FPT0WU
LC-1F NUP4WIhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTZwMEmyPVEh|ryP M2rzV3NCVkeHUh?=
TCCSUP MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTZwNkCzOFkh|ryP NXP0T2V1W0GQR1XS
TT NF7ze|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHWenlKSzVyPUiuN|MxODlizszN MlHqV2FPT0WU
NCI-H1838 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm1SlFKSzVyPUiuOVE4OzFizszN NFi1dWFUSU6JRWK=
NCI-H322M M1\qO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\lTWM2OD17LkG2NlgyKM7:TR?= NF7CRmZUSU6JRWK=
NCI-H187 M2O5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEftTm5KSzVyPUmuOVE5OzVizszN MnfvV2FPT0WU
SBC-1 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTlwOUO2OVYh|ryP NX3iUnFKW0GQR1XS
SCC-3 M{TxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\RTWM2OD1zMD61Olc6KM7:TR?= NH;YSItUSU6JRWK=
SW948 NY\IPGhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nCSGlEPTB;MUCuO|UyOSEQvF2= MmjuV2FPT0WU
CPC-N M3\GZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFzLkCwO{DPxE1? NIX4SpNUSU6JRWK=
TGBC24TKB NGHmU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF|LkWyPUDPxE1? NW[1PG0zW0GQR1XS
NCI-H2452 M3njOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjWdW9KSzVyPUG0Mlc{KM7:TR?= NWD0TYc3W0GQR1XS
Hs-578-T NHe4VIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvY[oRKSzVyPUG4MlU4PTlizszN M4TFeXNCVkeHUh?=
DV-90 M{Pz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTkTWM2OD1zOD65PVQ2KM7:TR?= MnrSV2FPT0WU
NCI-H1563 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn4VJd[UUN3ME2xPU44QDh6IN88US=> MmC4V2FPT0WU
SW780 NHf5T3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojhTWM2OD1{MT6xN|E5KM7:TR?= MYLTRW5ITVJ?
NCI-H345 NVrNcm5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnizTWM2OD1{MT64O|c6KM7:TR?= Mn3JV2FPT0WU
LB771-HNC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLzTWM2OD1{Mj60PFE{KM7:TR?= MlTmV2FPT0WU
RT4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDiTWM2OD1{Mz6zNlgzKM7:TR?= MVvTRW5ITVJ?
NCI-H82 NI\JdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q3ZmlEPTB;MkOuOVUzPiEQvF2= MYfTRW5ITVJ?
NCI-H524 M1r1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXoTWM2OD1{ND6zPFEzKM7:TR?= M4X2U3NCVkeHUh?=
SNU-C1 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKU2lEPTB;MkSuPVExPSEQvF2= NEDCOJhUSU6JRWK=
NCI-SNU-16 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LvWmlEPTB;NEiuN|E1OiEQvF2= M321dXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; 

PubMed: 23993685     


Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein.

E-cadherin / Cleaved PARP / Bim; 

PubMed: 23993685     


Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein.

HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; 

PubMed: 24796583     


CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control.

CDK4 / HMGA2 ; 

PubMed: 26893968     


HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.

23993685 24796583 26893968
Growth inhibition assay
Cell viability; 

PubMed: 26893968     


Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed in three independent experiments.

26893968
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
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Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
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  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
- Collapse
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Water Insoluble
Ethanol ''31 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms AUY-922
Smiles CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed Drug: LDK378|Drug: AUY922 Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Drug: AUY922 Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Drug: AUY922|Drug: BYL719 Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1
NCT01484860 Terminated Drug: AUY922 Adenocarcinoma of the Pancreas|Metastatic Disease University Health Network Toronto|Novartis Pharmaceuticals January 2012 Phase 2
NCT01402401 Terminated Drug: AUY922 + Trastuzumab Advanced Gastric Cancer Novartis Pharmaceuticals|Novartis November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID