Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK M3LJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMECwNVI2KM7:TR?= NELyNVlUSU6JRWK=
MV-4-11 M{n3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TSSmlEPTB;MD6wNFA2PThizszN NHzNR3VUSU6JRWK=
NALM-6 M1jJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMECwPFQzKM7:TR?= MnK5V2FPT0WU
HOS NF61SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXpZ3FKSzVyPUCuNFAyOzhizszN NGHFSHlUSU6JRWK=
HT-144 NVXme3ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECxOVUh|ryP NXnZUYo{W0GQR1XS
SW1710 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXOO|ZsUUN3ME2wMlAxOTh4IN88US=> NIH4TnlUSU6JRWK=
TE-8 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMECyN|ch|ryP NFfxXFdUSU6JRWK=
ES1 NIXkNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMECyOlYh|ryP M3zxXXNCVkeHUh?=
CCF-STTG1 NXz1d4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfZTWM2OD1yLkCwNlk4KM7:TR?= NEXmc2VUSU6JRWK=
PSN1 M1f4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vOXWlEPTB;MD6wNFMyQCEQvF2= NHflcIpUSU6JRWK=
CAL-51 NUT3TIJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fRc2lEPTB;MD6wNFMzPSEQvF2= M1Szc3NCVkeHUh?=
MCF7 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D2RmlEPTB;MD6wNFM{PSEQvF2= NULMclN7W0GQR1XS
SK-HEP-1 M1T1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnGTWM2OD1yLkCwN|M3KM7:TR?= NHzzR4xUSU6JRWK=
LCLC-103H NHnkeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEC0N{DPxE1? MWHTRW5ITVJ?
HMV-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEC0OFkh|ryP NF;XRZFUSU6JRWK=
MES-SA NWXoVmZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTNdnpDUUN3ME2wMlAxPDV{IN88US=> NUftVZJCW0GQR1XS
SK-LMS-1 NUfjdpFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrrSIlyUUN3ME2wMlAxPDV6IN88US=> NI\3N4hUSU6JRWK=
639-V NELRWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEC0PFUh|ryP MnHNV2FPT0WU
SIG-M5 NUnYZm9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEC0PFkh|ryP M1rnW3NCVkeHUh?=
LOUCY NUHmd5JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf3TWM2OD1yLkCwOVA2KM7:TR?= NVmzRpZNW0GQR1XS
HSC-2 NEC2UJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXnUVZKSzVyPUCuNFA2OThizszN NUi2XJBIW0GQR1XS
EW-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEC1NVgh|ryP NUXCdZl5W0GQR1XS
RT-112 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEC1N|Uh|ryP M4L5bnNCVkeHUh?=
NKM-1 M{SxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEC1OFch|ryP NYXPfGl6W0GQR1XS
KYSE-180 NXrnUJF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEC1PFYh|ryP M{XmN3NCVkeHUh?=
SW1783 NVS3foRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXlTWM2OD1yLkCwOVkyKM7:TR?= MojTV2FPT0WU
A431 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\sXlFxUUN3ME2wMlAxPjB5IN88US=> MWjTRW5ITVJ?
SK-OV-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnCe3dKSzVyPUCuNFA3OyEQvF2= MUTTRW5ITVJ?
RPMI-7951 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rTNGlEPTB;MD6wNFY{OSEQvF2= MlnvV2FPT0WU
Capan-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPxTWM2OD1yLkCwOlM5KM7:TR?= MYHTRW5ITVJ?
HSC-3 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOyNIpKSzVyPUCuNFA3PDFizszN MmXYV2FPT0WU
786-0 M2\yOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;qPWhKSzVyPUCuNFA3PjNizszN M17BdHNCVkeHUh?=
Daoy MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHOcJlQUUN3ME2wMlAxPjl3IN88US=> M1LIXHNCVkeHUh?=
KGN NYHsUmhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzJT5NkUUN3ME2wMlAxPzB|IN88US=> NFXQe4JUSU6JRWK=
EW-16 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17qWGlEPTB;MD6wNFc1QSEQvF2= MnriV2FPT0WU
EW-7 NXX5R|NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3WTWM2OD1yLkCwO|U1KM7:TR?= NYG0VId5W0GQR1XS
IGROV-1 NX\F[25ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3wNodKSzVyPUCuNFA5OTRizszN NFL3d5hUSU6JRWK=
8505C Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTE[oxKSzVyPUCuNFA5OjFizszN NXywTWVWW0GQR1XS
RKO NYf2OVRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rqXmlEPTB;MD6wNFgzPiEQvF2= MYfTRW5ITVJ?
GDM-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\1TWM2OD1yLkCwPFQh|ryP NU\uNYdCW0GQR1XS
IST-MEL1 NFq0dGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD6[HBzUUN3ME2wMlAxQDV{IN88US=> NWe0[2dXW0GQR1XS
RPMI-6666 M4\XWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVntZ4FVUUN3ME2wMlAxQDV{IN88US=> Ml;PV2FPT0WU
SNG-M MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2npXmlEPTB;MD6wNFg2PiEQvF2= NWXaR4JKW0GQR1XS
KS-1 NH;uVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEC4OVkh|ryP M4iyRXNCVkeHUh?=
RXF393 MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC5fWRKUUN3ME2wMlAxQDZizszN MVrTRW5ITVJ?
CAL-12T M1\E[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEC5NlIh|ryP NF;ncnhUSU6JRWK=
BFTC-905 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEftT3RKSzVyPUCuNFA6OzhizszN NEjwT2lUSU6JRWK=
SK-MES-1 NIj6fY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf5d2tKUUN3ME2wMlAxQTR3IN88US=> MVLTRW5ITVJ?
BB30-HNC MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXtUWpKSzVyPUCuNFA6PTJizszN MkTaV2FPT0WU
AN3-CA M17PN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\vW4VKSzVyPUCuNFExOTdizszN NV:5WHUzW0GQR1XS
EFO-27 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnwSGh6UUN3ME2wMlAyODF5IN88US=> MWfTRW5ITVJ?
G-401 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL6TWM2OD1yLkCxNFI2KM7:TR?= M{GyRnNCVkeHUh?=
BPH-1 NFPpVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfpUWtMUUN3ME2wMlAyODNizszN Mn7TV2FPT0WU
NCI-H727 NXjQ[WIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i2[GlEPTB;MD6wNVA{KM7:TR?= NEHsfndUSU6JRWK=
SNU-423 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm2TWM2OD1yLkCxNFU{KM7:TR?= NYiyW2xIW0GQR1XS
KYSE-270 NXHpUmNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rVWWlEPTB;MD6wNVA2QSEQvF2= M2e1THNCVkeHUh?=
AGS NXjKSJE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEGwOlEh|ryP Mm\lV2FPT0WU
NCI-H2228 NInGWmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\m[mlEPTB;MD6wNVA3PCEQvF2= NYTQ[FZVW0GQR1XS
SW954 M3W4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17h[GlEPTB;MD6wNVA4OSEQvF2= NE\zd45USU6JRWK=
769-P MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr2dVFKSzVyPUCuNFExPzNizszN MYPTRW5ITVJ?
BB49-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf6fYVIUUN3ME2wMlAyODd5IN88US=> NYXvV3VEW0GQR1XS
IA-LM Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TqdmlEPTB;MD6wNVA5PiEQvF2= NF;ZR|RUSU6JRWK=
NB69 NWPWSlFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPuTWM2OD1yLkCxNVAzKM7:TR?= Mkf5V2FPT0WU
C8166 NEDyd|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD1yLkCxNVI6KM7:TR?= NIfrNIRUSU6JRWK=
NCI-H1299 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fid2lEPTB;MD6wNVE2PCEQvF2= NILqSG5USU6JRWK=
YKG-1 M{HJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGcWlEPTB;MD6wNVE3KM7:TR?= NEG2XppUSU6JRWK=
PANC-03-27 M4LWU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojrTWM2OD1yLkCxNVYzKM7:TR?= M{THZXNCVkeHUh?=
YT M2jDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEGxO|kh|ryP NUWwU|VMW0GQR1XS
CAL-85-1 M4HvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz3fm9KSzVyPUCuNFEyQTJizszN M{H0c3NCVkeHUh?=
GT3TKB MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL0TWM2OD1yLkCxNlAzKM7:TR?= NYe4c45vW0GQR1XS
BB65-RCC M1ftd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXSTWM2OD1yLkCxNlA1KM7:TR?= NVnXRpMzW0GQR1XS
ES6 NFjwZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHyxbWVKSzVyPUCuNFEzPjFizszN NXnEdFdIW0GQR1XS
MHH-ES-1 NFfrblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEGyOlMh|ryP MUHTRW5ITVJ?
QIMR-WIL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEGyOlkh|ryP NFnkNXpUSU6JRWK=
SNU-C2B NGjiU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vpTWlEPTB;MD6wNVI4OiEQvF2= NXjuVXVpW0GQR1XS
OCI-AML2 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vlZWlEPTB;MD6wNVI5OSEQvF2= M3rFb3NCVkeHUh?=
DU-145 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPZm1LUUN3ME2wMlAyOjlizszN MVPTRW5ITVJ?
SW982 NVzz[oFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEGyPVMh|ryP MUDTRW5ITVJ?
MFH-ino M1zuPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzaWpVZUUN3ME2wMlAyOjl|IN88US=> NWPJcZVQW0GQR1XS
A427 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf6Oo5KSzVyPUCuNFEzQTlizszN M4G2NnNCVkeHUh?=
LCLC-97TM1 NGXyW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H4VWlEPTB;MD6wNVMh|ryP M2XZXXNCVkeHUh?=
AM-38 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPhTWM2OD1yLkCxN|AzKM7:TR?= NHT6cJhUSU6JRWK=
K5 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPQTJJ{UUN3ME2wMlAyOzB6IN88US=> MWDTRW5ITVJ?
T84 NGH2NHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XLR2lEPTB;MD6wNVM{OSEQvF2= MY\TRW5ITVJ?
TE-15 NUfBV3dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vKN2lEPTB;MD6wNVM{PiEQvF2= MlvpV2FPT0WU
NCI-H460 NXzMWo5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDr[lMyUUN3ME2wMlAyOzN4IN88US=> M4jSN3NCVkeHUh?=
NTERA-S-cl-D1 NIj5T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvSTWM2OD1yLkCxN|M6KM7:TR?= NFG5Um5USU6JRWK=
KYSE-450 M3vMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLTTWM2OD1yLkCxN|Q6KM7:TR?= NHuyVlhUSU6JRWK=
H4 NXnBVZhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nlS2lEPTB;MD6wNVM3PiEQvF2= NVPQS|dxW0GQR1XS
LC-2-ad MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7iTWM2OD1yLkCxN|ch|ryP MYjTRW5ITVJ?
GAMG MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEGzO|Eh|ryP NWPKd2FsW0GQR1XS
TK10 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PvO2lEPTB;MD6wNVM5OiEQvF2= MWTTRW5ITVJ?
NCI-H2122 MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nBTGlEPTB;MD6wNVM5PCEQvF2= MVrTRW5ITVJ?
KM12 M1TkSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf2VpNKSzVyPUCuNFE{QTlizszN MoraV2FPT0WU
CAL-39 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorSTWM2OD1yLkCxOFIh|ryP NFfJc2dUSU6JRWK=
RPMI-2650 NVrycGdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrFTWM2OD1yLkCxOFMzKM7:TR?= MVfTRW5ITVJ?
KYSE-510 M1zzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TjPWlEPTB;MD6wNVQ1OiEQvF2= NYfDVmlnW0GQR1XS
KALS-1 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfWTWM2OD1yLkCxOFY3KM7:TR?= NGTXbZlUSU6JRWK=
NCI-H1648 M{fT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXVO5NKSzVyPUCuNFE1QTlizszN MoLwV2FPT0WU
ES4 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\PN2kxUUN3ME2wMlAyPTB{IN88US=> M2SzUnNCVkeHUh?=
C-33-A M2riZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r4b2lEPTB;MD6wNVUxQSEQvF2= MWTTRW5ITVJ?
MIA-PaCa-2 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7VSYdIUUN3ME2wMlAyPTB7IN88US=> M2HWTnNCVkeHUh?=
Becker NV\GO4lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvmTWM2OD1yLkCxOVE1KM7:TR?= MV7TRW5ITVJ?
HOP-62 M1T0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSzPGVPUUN3ME2wMlAyPTR{IN88US=> M1PYfXNCVkeHUh?=
TE-1 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnIfnFKSzVyPUCuNFE2QDFizszN M3uwV3NCVkeHUh?=
KYSE-410 NVvwV4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEG1PFYh|ryP M{TDSnNCVkeHUh?=
NOS-1 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj0RlVKSzVyPUCuNFE2QTNizszN Ml36V2FPT0WU
MEL-HO NI\HZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j2emlEPTB;MD6wNVY1OyEQvF2= MVnTRW5ITVJ?
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VMRC-RCZ NHWwSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\1[WxKSzVyPUCuNFE3PTFizszN M{jjfXNCVkeHUh?=
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OS-RC-2 NXXmN4R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XQV2lEPTB;MD6wN|M6PiEQvF2= MYHTRW5ITVJ?
SF268 M321[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3JTWM2OD1yLkCzOFAyKM7:TR?= M4\DNHNCVkeHUh?=
BV-173 NWTRXYtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEO0NlYh|ryP MnnvV2FPT0WU
DMS-273 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGzVphlUUN3ME2wMlA{PDd7IN88US=> NFHk[mJUSU6JRWK=
22RV1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\0W2lEPTB;MD6wN|UxPyEQvF2= MX;TRW5ITVJ?
ES8 NVzOcnV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\jTWM2OD1yLkCzOVM5KM7:TR?= MlrrV2FPT0WU
KYSE-150 MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuxSYhKSzVyPUCuNFM3ODhizszN M{TYbnNCVkeHUh?=
HCC1569 NUT6Z2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEO2NFgh|ryP NXnicohKW0GQR1XS
NB5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvTTWM2OD1yLkCzOlE{KM7:TR?= NVHkZWc4W0GQR1XS
G-402 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLpTWM2OD1yLkCzOlE1KM7:TR?= NEXhNGtUSU6JRWK=
NCI-H1693 M3\XXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf1TWM2OD1yLkCzOlE4KM7:TR?= Mo\uV2FPT0WU
LB2241-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO1TlhKSzVyPUCuNFM3PDJizszN MYPTRW5ITVJ?
KP-4 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:xPVZmUUN3ME2wMlA{PjZ|IN88US=> M3TTTHNCVkeHUh?=
ML-2 NYKyVnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEO2O|Eh|ryP NVPsTWVGW0GQR1XS
KU812 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\oeXd{UUN3ME2wMlA{Pjh2IN88US=> NVrNUnlVW0GQR1XS
LS-411N MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzMTWM2OD1yLkCzO|MyKM7:TR?= MmPxV2FPT0WU
OAW-42 NYLBTXpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEO3OFch|ryP NWrSZ|k3W0GQR1XS
HCC38 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfOc5FKSzVyPUCuNFM4PzFizszN NV7aUnBTW0GQR1XS
Ca-Ski MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjUb2xKSzVyPUCuNFM4QDRizszN MUfTRW5ITVJ?
Calu-3 NILJSJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn0cm5KSzVyPUCuNFM4QDlizszN NXu2VHpNW0GQR1XS
KYSE-70 NIfyclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn61TWM2OD1yLkCzPFEzKM7:TR?= M{\3c3NCVkeHUh?=
D-392MG NGruc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvlbpFKSzVyPUCuNFM5PDJizszN MUTTRW5ITVJ?
OVCAR-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEO4OVgh|ryP NUK2bm9PW0GQR1XS
Detroit562 NEP5TJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfTSYZCUUN3ME2wMlA{QDd{IN88US=> NIHRRY9USU6JRWK=
HEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEO4PVEh|ryP NEjIVnhUSU6JRWK=
MONO-MAC-6 NUDNRoNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rNSGlEPTB;MD6wN|g6OyEQvF2= NVLm[XlVW0GQR1XS
LoVo M{XCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\VeFJKSzVyPUCuNFM6OzNizszN MX7TRW5ITVJ?
U-2-OS NFTGUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnmTWM2OD1yLkCzPVM2KM7:TR?= NH7NNIlUSU6JRWK=
A172 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEO5OUDPxE1? M4DmRXNCVkeHUh?=
OCUB-M NV[yTXpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEO5OlEh|ryP MXHTRW5ITVJ?
SW48 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMESwN|Eh|ryP M2PsNHNCVkeHUh?=
HC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDocJBKSzVyPUCuNFQxPjlizszN MUnTRW5ITVJ?
KOSC-2 M1\Zbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz3cnBKSzVyPUCuNFQyOSEQvF2= MVXTRW5ITVJ?
HDLM-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ob2lEPTB;MD6wOFEyPCEQvF2= MVvTRW5ITVJ?
CTV-1 NFfNdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjuU3hKSzVyPUCuNFQyOTZizszN MnrSV2FPT0WU
SH-4 NW\5emRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXi[opKSzVyPUCuNFQyPDFizszN NVzyTlNRW0GQR1XS
SW756 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XUc2lEPTB;MD6wOFE2PyEQvF2= Mo\ZV2FPT0WU
GCT MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITBUohKSzVyPUCuNFQyPjFizszN M2XEUnNCVkeHUh?=
CHL-1 NUTQUlN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq0TWM2OD1yLkC0NVY6KM7:TR?= M1zwPXNCVkeHUh?=
LAMA-84 M3vxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYToRVZXUUN3ME2wMlA1OTdzIN88US=> NFfRbmRUSU6JRWK=
LS-1034 NYLSPHZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G3XmlEPTB;MD6wOFE6OSEQvF2= Ml24V2FPT0WU
NCI-H358 NUOzOWVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnraTWM2OD1yLkC0NlEzKM7:TR?= MVXTRW5ITVJ?
NB13 M3jyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ETWM2OD1yLkC0NlI4KM7:TR?= MVrTRW5ITVJ?
TE-9 NWqwVo1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13CZ2lEPTB;MD6wOFI{PyEQvF2= NVL2R|kxW0GQR1XS
OE33 NYL2bnVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMESyOFEh|ryP Mk\KV2FPT0WU
CAL-120 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfyepI1UUN3ME2wMlA1OjRzIN88US=> NHvST4lUSU6JRWK=
DJM-1 Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjzdlJKSzVyPUCuNFQzPzJizszN NY[yR5ZYW0GQR1XS
SK-MEL-24 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPyflE3UUN3ME2wMlA1Ojh|IN88US=> MmTJV2FPT0WU
VA-ES-BJ Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz5VJhKSzVyPUCuNFQzQTJizszN MUTTRW5ITVJ?
MMAC-SF MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLNTWM2OD1yLkC0Nlk4KM7:TR?= M4q1SnNCVkeHUh?=
MZ7-mel MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDLZ5puUUN3ME2wMlA1OzNizszN MnSyV2FPT0WU
BxPC-3 NVHRXpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMESzOFEh|ryP M4fBbHNCVkeHUh?=
HT-29 M13qcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrHb49RUUN3ME2wMlA1OzV5IN88US=> Mn\4V2FPT0WU
SK-MEL-30 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;NTWM2OD1yLkC0N|YzKM7:TR?= NWrqRVZYW0GQR1XS
CAL-33 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[xSmlEPTB;MD6wOFM4PSEQvF2= NY\tSVRIW0GQR1XS
COLO-680N NWL1VJo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES5SI5KSzVyPUCuNFQ1ODdizszN NGLtV5VUSU6JRWK=
NH-12 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3DRohKSzVyPUCuNFQ1PCEQvF2= MnPNV2FPT0WU
HCC1937 M3zTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL1WopKSzVyPUCuNFQ1PTZizszN Mkm5V2FPT0WU
IMR-5 M1vF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPMTWM2OD1yLkC0OFkh|ryP NH62RZBUSU6JRWK=
MC-CAR NVi0R5IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XYXWlEPTB;MD6wOFU3QSEQvF2= MmO1V2FPT0WU
NCI-H747 NF7xcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELmPIhKSzVyPUCuNFQ2PyEQvF2= NWi5S203W0GQR1XS
NCI-H1792 NWHh[oc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHN[JJKSzVyPUCuNFQ2QDFizszN MUjTRW5ITVJ?
SW13 M3;zPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HFWGlEPTB;MD6wOFU6KM7:TR?= M3THenNCVkeHUh?=
MLMA MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnewTWM2OD1yLkC0OlA6KM7:TR?= Mn3LV2FPT0WU
U251 M3LhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV25fZFuUUN3ME2wMlA1PzZ|IN88US=> NYPFSYIxW0GQR1XS
U031 NVzafopUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfuUVdKSzVyPUCuNFQ4PzFizszN MUXTRW5ITVJ?
ME-180 NFnFSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\qbGlEPTB;MD6wOFc5OiEQvF2= MXnTRW5ITVJ?
SK-MEL-3 NX\WTpNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDxTWM2OD1yLkC0PFAzKM7:TR?= M3:0c3NCVkeHUh?=
MOLT-4 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMES4NFMh|ryP NYHuXmNWW0GQR1XS
PF-382 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm5VVFXUUN3ME2wMlA1QDJ4IN88US=> M4fPe3NCVkeHUh?=
NUGC-3 NHnPb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnRdFdKSzVyPUCuNFQ5OjdizszN MorvV2FPT0WU
NCI-H1417 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMES4PUDPxE1? NHraZlJUSU6JRWK=
COLO-205 NG\NSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH1TIxKSzVyPUCuNFQ6OTlizszN M{[yd3NCVkeHUh?=
TE-441-T NUiz[m5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjnVI9KSzVyPUCuNFQ6OyEQvF2= NVm1ZpJsW0GQR1XS
MKN1 M3zZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P2VWlEPTB;MD6wOFk{KM7:TR?= MoXPV2FPT0WU
UM-UC-3 NED2cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr3d2c{UUN3ME2wMlA1QTVizszN NWj1ZmxKW0GQR1XS
SF126 NYLhdIt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnvXWFZUUN3ME2wMlA2ODFizszN NX3SU3JxW0GQR1XS
LB1047-RCC NFzHbpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLKSGNWUUN3ME2wMlA2ODNzIN88US=> M4HybnNCVkeHUh?=
A253 Moi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHLTWM2OD1yLkC1NFUzKM7:TR?= MXnTRW5ITVJ?
NCI-H1963 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEWxO|Yh|ryP MlvsV2FPT0WU
VM-CUB-1 NX3aWFJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj5XnBKSzVyPUCuNFU{OTFizszN MmfTV2FPT0WU
T-24 M4fOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXW[5k6UUN3ME2wMlA2Ozh2IN88US=> NITPN4JUSU6JRWK=
K-562 M4Drbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\F[|dKSzVyPUCuNFU{QDdizszN MmXiV2FPT0WU
ARH-77 NHTRSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX33ZYFqUUN3ME2wMlA2Ozl3IN88US=> NIjxUpJUSU6JRWK=
CA46 MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEW0N{DPxE1? MWjTRW5ITVJ?
HCC70 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjtVZNKSzVyPUCuNFU1PTJizszN M{i3fHNCVkeHUh?=
ST486 M1TiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PObmlEPTB;MD6wOVUzPSEQvF2= MkHUV2FPT0WU
COLO-741 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEW1N|Eh|ryP NYnPZ4w4W0GQR1XS
SK-PN-DW M4PNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHMfVZKSzVyPUCuNFU2QDhizszN M{TwWHNCVkeHUh?=
BL-41 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyyTWM2OD1yLkC1OVk3KM7:TR?= NWLXNoViW0GQR1XS
D-263MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj5TWM2OD1yLkC1Olg{KM7:TR?= MXXTRW5ITVJ?
KE-37 NXjMb5VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEW2PFMh|ryP NXHO[ZlUW0GQR1XS
LU-134-A NUfNO3dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEW3NVUh|ryP M2LTcnNCVkeHUh?=
HCC2157 M2D2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PGd2lEPTB;MD6wOVc{OyEQvF2= M4[yTXNCVkeHUh?=
GAK NUOxdmc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojmTWM2OD1yLkC1O|M1KM7:TR?= MoPZV2FPT0WU
IST-SL2 NUS2cIdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEW3OFMh|ryP NXXHOJFjW0GQR1XS
KMOE-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjpcHBKSzVyPUCuNFU4PDlizszN NXjuem5XW0GQR1XS
SW1573 NFv6UldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fUT2lEPTB;MD6wOVgxOiEQvF2= MknwV2FPT0WU
SCC-9 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPUeY9UUUN3ME2wMlA2QDdizszN MXXTRW5ITVJ?
MDA-MB-361 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfOV3prUUN3ME2wMlA2QDd{IN88US=> NHPkNY9USU6JRWK=
BHT-101 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3XpZRUUN3ME2wMlA2QDd4IN88US=> NHPjWHlUSU6JRWK=
NCI-H1770 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEW4O|kh|ryP M{H1b3NCVkeHUh?=
UACC-893 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEW4PVYh|ryP Mnz3V2FPT0WU
NCI-H226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEW5PFgh|ryP MkKzV2FPT0WU
HLE M1u5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHXWoxuUUN3ME2wMlA3ODh{IN88US=> MWTTRW5ITVJ?
NCI-H1703 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7hTWM2OD1yLkC2NVc5KM7:TR?= MmfUV2FPT0WU
KURAMOCHI MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvBTmY5UUN3ME2wMlA3OTh7IN88US=> MYXTRW5ITVJ?
RH-1 MoK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PTV2lEPTB;MD6wOlI{KM7:TR?= MYLTRW5ITVJ?
DSH1 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnGTWM2OD1yLkC2Nlch|ryP M{W4bnNCVkeHUh?=
CAMA-1 NWTye2M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX2bHhzUUN3ME2wMlA3OzB|IN88US=> NHz4eohUSU6JRWK=
NCI-H1437 NUDOeG8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwME[zNlgh|ryP NEnte4xUSU6JRWK=
HuP-T4 NUTjN|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjwTWM2OD1yLkC2OVg3KM7:TR?= NInXeIRUSU6JRWK=
HCT-15 NFrOWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;t[5FKSzVyPUCuNFY2QTdizszN NEjYbWVUSU6JRWK=
NCCIT M3LFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj5b4FKSzVyPUCuNFY3ODRizszN NYDKdVk6W0GQR1XS
BOKU NGfRcFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLITWM2OD1yLkC2Olc1KM7:TR?= MnPsV2FPT0WU
FADU MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfPTWM2OD1yLkC2O|Q2KM7:TR?= M{HIPXNCVkeHUh?=
SUP-T1 NFrScG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK5TWM2OD1yLkC2O|Yh|ryP NV;XfGNvW0GQR1XS
L-363 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XJcWlEPTB;MD6wOlkxOSEQvF2= MmDyV2FPT0WU
KNS-81-FD NGrHRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH5TWM2OD1yLkC2PVE5KM7:TR?= M1ftVnNCVkeHUh?=
SU-DHL-1 M4\FbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TWW2lEPTB;MD6wOlkzKM7:TR?= MWLTRW5ITVJ?
HuH-7 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLWPYNKSzVyPUCuNFcxOzVizszN NHXsSmtUSU6JRWK=
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SIMA MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7YTWM2OD1yLkexO|E6KM7:TR?= MlfGV2FPT0WU
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SF539 NILhPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7L[lBqUUN3ME2wMlc6QTJ3IN88US=> MnHwV2FPT0WU
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HAL-01 M4fBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Me4xMUUN3ME2wMlk6Ozd7IN88US=> MWDTRW5ITVJ?
NCI-H1993 M4rkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwMES2OVch|ryP MV7TRW5ITVJ?
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TALL-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\hTmlEPTB;MT6yOVE3PSEQvF2= MnPpV2FPT0WU
RO82-W-1 NF;3SXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV20XJY{UUN3ME2xMlM{OzN7IN88US=> MkW3V2FPT0WU
NCI-H1581 NYHoZnVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jNT2lEPTB;MT6zOVY5PyEQvF2= MoDmV2FPT0WU
NCI-H748 M4H6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vwV2lEPTB;MT6zOVc{QCEQvF2= NF;sVXZUSU6JRWK=
HCC1187 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3aT5hKSzVyPUGuOVU2OjJizszN M{TJcnNCVkeHUh?=
EoL-1-cell MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXoWmZKSzVyPUGuOVg5QDlizszN NFzNeVRUSU6JRWK=
HuO-3N1 M3TlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjSZ|U4UUN3ME2xMlg{PDF{IN88US=> MoXUV2FPT0WU
NCI-H1793 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwOEe1PVMh|ryP Mn7FV2FPT0WU
Caov-3 NFz1cWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTRTWM2OD1{LkCwOlI2KM7:TR?= NWnZfG5OW0GQR1XS
JAR MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwMEe5NkDPxE1? NEe0R5BUSU6JRWK=
SK-MEL-28 NG\IXJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofYTWM2OD1{LkG4NFk5KM7:TR?= MkTVV2FPT0WU
EM-2 M3XsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJwMkCyPVMh|ryP MVLTRW5ITVJ?
Mewo NFvWfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zVNmlEPTB;Mj6yNlI3PSEQvF2= NGniOXJUSU6JRWK=
NCI-H720 NHnxbmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X5WGlEPTB;Mj6yOlU5PSEQvF2= NIDjWmJUSU6JRWK=
CAL-54 NFrqNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO3fHZKSzVyPUKuNlY4QTVizszN MXHTRW5ITVJ?
MC116 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjFTWM2OD1{LkO2N|k4KM7:TR?= NVzxS2txW0GQR1XS
DG-75 NIPJSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwNEi1O|Yh|ryP NYnncIJrW0GQR1XS
HCC1143 NXrQVoo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TsPGlEPTB;Mj61NFY2QCEQvF2= MkHKV2FPT0WU
FTC-133 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPnSXVKSzVyPUKuOVM3QDlizszN MYTTRW5ITVJ?
AsPC-1 NVG5S5BWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDZNotDUUN3ME2yMlU{QTJ7IN88US=> NVfV[WllW0GQR1XS
NCI-H889 M4PldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrZTWM2OD1{LkW2O|A3KM7:TR?= NWHkbHpDW0GQR1XS
HT55 M3HXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rOS2lEPTB;Mj62NlAyQSEQvF2= M4PkVHNCVkeHUh?=
UMC-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJwN{i3NVUh|ryP M3fpSHNCVkeHUh?=
P12-ICHIKAWA NI\GbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jtVmlEPTB;Mj64NlA1PiEQvF2= NH;YOVlUSU6JRWK=
HCC1395 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHpNItvUUN3ME2yMlk5PjB{IN88US=> MYnTRW5ITVJ?
D-283MED NX:3UFJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonwTWM2OD1|LkG4PVM4KM7:TR?= NILqR3FUSU6JRWK=
COLO-800 M2TuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XrfGlEPTB;Mz6zN|g6PyEQvF2= Mne4V2FPT0WU
MFM-223 M33MVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTNwM{[wPVch|ryP NUK4UIprW0GQR1XS
TE-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRwNU[xOFch|ryP NIL1fW1USU6JRWK=
NCI-H209 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTuSoxKSzVyPUSuO|g2PzJizszN MXjTRW5ITVJ?
SiHa M{j3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHiRYo5UUN3ME20Mlk2OjB|IN88US=> MlraV2FPT0WU
NCI-H1395 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPJflc1UUN3ME21MlExPjN|IN88US=> MnjJV2FPT0WU
A498 MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:zTWM2OD13LkKxNlUyKM7:TR?= MUXTRW5ITVJ?
ES5 NFOxRphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zhZmlEPTB;NT62NVE4QCEQvF2= MoXIV2FPT0WU
MDA-MB-157 NGGwdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jlRWlEPTB;NT62OlQ1OyEQvF2= NETIfHBUSU6JRWK=
NCI-H1623 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzxeJVTUUN3ME21Mlg{PTV4IN88US=> NVrObm5mW0GQR1XS
RPMI-8866 NVjRZ3F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjpUWlKSzVyPUWuPFQ4QTJizszN NFHGNpBUSU6JRWK=
LC-1F NETHdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rmZWlEPTB;Nj6wPVI6OSEQvF2= MV3TRW5ITVJ?
TCCSUP MnjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Cxe2lEPTB;Nj62NFM1QSEQvF2= MmLQV2FPT0WU
TT MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PHN2lEPTB;OD6zN|AxQSEQvF2= NV3zXIdwW0GQR1XS
NCI-H1838 M4ThPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRThwNUG3N|Eh|ryP NGXJWYJUSU6JRWK=
NCI-H322M MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTlwMU[yPFEh|ryP Mlz1V2FPT0WU
NCI-H187 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjHO2RKSzVyPUmuOVE5OzVizszN M4rlO3NCVkeHUh?=
SBC-1 NVjLXVQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rYcGlEPTB;OT65N|Y2PiEQvF2= NHfpNmtUSU6JRWK=
SCC-3 NVfZZmZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvTOotVUUN3ME2xNE42Pjd7IN88US=> MUnTRW5ITVJ?
SW948 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;SdWlEPTB;MUCuO|UyOSEQvF2= M3XuRnNCVkeHUh?=
CPC-N MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPETWM2OD1zMT6wNFch|ryP MV\TRW5ITVJ?
TGBC24TKB MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr0NGZGUUN3ME2xN{42OjlizszN Mor2V2FPT0WU
NCI-H2452 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSzTG5RUUN3ME2xOE44OyEQvF2= NYPwS4d2W0GQR1XS
Hs-578-T M3TqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDPcnpKSzVyPUG4MlU4PTlizszN MYPTRW5ITVJ?
DV-90 NFvKPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW4fmpKSzVyPUG4Mlk6PDVizszN M{\vWXNCVkeHUh?=
NCI-H1563 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7hTWM2OD1zOT63PFg5KM7:TR?= NXHqZpBsW0GQR1XS
SW780 M1j5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJzLkGzNVgh|ryP NX[xeJFLW0GQR1XS
NCI-H345 M17ONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\STWM2OD1{MT64O|c6KM7:TR?= MoXJV2FPT0WU
LB771-HNC NVTF[GlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHiTWM2OD1{Mj60PFE{KM7:TR?= NE\GTYdUSU6JRWK=
RT4 NWLKTlJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C3WWlEPTB;MkOuN|I5OiEQvF2= NIfjc2FUSU6JRWK=
NCI-H82 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ|LkW1NlYh|ryP NWTq[Iw{W0GQR1XS
NCI-H524 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXDZ2wxUUN3ME2yOE4{QDF{IN88US=> NX70XJdkW0GQR1XS
SNU-C1 NWe2e2kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0WWlEPTB;MkSuPVExPSEQvF2= M2n2XXNCVkeHUh?=
NCI-SNU-16 NGXIWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe3U|RKSzVyPUS4MlMyPDJizszN MUTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID