Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

Size Price Stock Quantity  
In DMSO USD 156 In stock
USD 120 In stock
USD 370 In stock
Bulk Discount
Bulk Inquiry

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 78 Publications

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
Targets
PARP2 [1]
(Cell-free assay)		 PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 MWXLbY5ie2ViQYPzZZk> MXKzNEBucW5? MX3Jcohq[mm2aX;uJI9nKFCDUmCxJJdqfGhiRVO1NEBw\iByLkCwNkDPxE1? NYrESohLOTl6OEi3OlA>
Jurkat NGT2fVhMcW6jc3WgRZN{[Xl? MXK5OkBp MXLEUXNQ NYHJRWFTUW6qaXLpeIlwdiCxZjDQRXJROSCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2WubDD2bYFjcWyrdImge4l1cCCHQ{WwJI9nKDNizszN NWrFbnBqOjN6NUCxPVk>
Capan1 NXjVOY1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jmRlczKGh? NFjYTnlFVVOR Ml;5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCVmNCOiCpZX7lJI12fGG2ZXSgbJVu[W5iQ3HwZY4yKGOnbHzzJJdqfGhiSVO1NEBw\iB|OT63JO69VQ>? NFu4VFAzPDN7OEO4Ny=>
DT40 MmX0R5l1d3SxeHnjJGF{e2G7 NFPIW|I4OiCq NFLvV|VFVVOR NYi3Sld[S3m2b4TvfIlkcXS7IHHnZYlve3RiY3jpZ4tmdiCEUlPBNk1l\W[rY3nlcpQhTFR2MDDj[Yxtew>? NWnXU2l4OjR7MkK1PFc>
ML-1 MmnpRZBweHSxdHnjJGF{e2G7 M360XFIvPSEQvF2= NF63bFMzPCCq NXjoVYtkTE2VTx?= MWXTfY5memerc4TpZ4FtdHliZX7oZY5k\XNiVGLBTWwucW6mdXPl[EBieG:ydH;zbZMhcW5iTVytNUBk\Wyucx?= M2LISFI1QDl3MUO1
HCT-116 MV3LbY5ie2ViQYPzZZk> NELEepIxNjVizszN NG\FR4MzPCCq MlfoVGFTWCCjY4Tpeol1gSCmZXPy[YF{\XN? NX\nOlVIOjNyNUSyNVM>
UM-SCC1 NIGwZ3FEgXSxdH;4bYMhSXO|YYm= MknmNVAh|ryP MmPpNlQhcA>? M4ixW3Jm\HWlZYOgeIhmKGOnbHygeoli[mmuaYT5 NEjjc3gzOTlzMk[yNC=>
FaDu NHWzU3JEgXSxdH;4bYMhSXO|YYm= MnuyNVAh|ryP NHqyNGIzPCCq M3XCUHJm\HWlZYOgeIhmKGOnbHygeoli[mmuaYT5 NI\XPXMzOTlzMk[yNC=>
PC-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi4SHoyOCEQvF2= NHnV[GlKdmS3Y3XzJIEhe2mpbnnmbYNidnRiaX7obYJqfGmxbjDpckBkd2yxbomg[o9zdWG2aX;uxsA> MV6yNVU4OTlzMh?=
EoL-1-cell MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37Qb2lEPTB;MT6wO|k5KM7:TR?= NF3yVWJUSU6JRWK=
NCI-SNU-5 NEexN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnhW5NKUUN3ME2zMlEzQDRzIN88US=> NFraem1USU6JRWK=
BV-173 NXjveXBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnOb25RUUN3ME21MlQ2PDB7IN88US=> M4HMdnNCVkeHUh?=
HCC1806 NEDPco1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXrTWM2OD13Lke1NVc{KM7:TR?= NH;aRoNUSU6JRWK=
COLO-680 M2S3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\0R4xZUUN3ME22MlIyPDB4IN88US=> MVzTRW5ITVJ?
HCC2218 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTdwN{m3NFQh|ryP NEDsfHVUSU6JRWK=
SK-MEL-24 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTdwOEG5NlQh|ryP NED6fIRUSU6JRWK=
NCI-H720 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fHXGlEPTB;OD60N|YxOyEQvF2= MmK0V2FPT0WU
KASUMI-1 NGq2[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfQTWM2OD16Lki5NlY3KM7:TR?= M2[5THNCVkeHUh?=
HAL-01 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljSTWM2OD17Lki4OlIh|ryP MWnTRW5ITVJ?
CAL-33 NIPj[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7UUFRKSzVyPUGwMlQ{PCEQvF2= NF6xPVdUSU6JRWK=
SK-MEL-1 NVizWWlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf2SodKSzVyPUGyMlQ3PjNizszN NXrXVWtZW0GQR1XS
Ramos-2G6-4C10 MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T3TGlEPTB;MUKuOFc2OiEQvF2= NVzqcmtyW0GQR1XS
KY821 M1XmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF{LkS4OUDPxE1? MXrTRW5ITVJ?
HEC-1 NXTFXIJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrIeXFuUUN3ME2xNk46OTl4IN88US=> MnTIV2FPT0WU
SK-NEP-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXicFM1UUN3ME2xN{4yPjZizszN Ml7BV2FPT0WU
MN-60 M4P4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF|LkWzPFkh|ryP NWf0TFJnW0GQR1XS
DU-145 NI\FT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmzPI46UUN3ME2xN{46ODV|IN88US=> MVjTRW5ITVJ?
EW-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[3e21iUUN3ME2xOE42PTZ3IN88US=> M3nv[XNCVkeHUh?=
OS-RC-2 NHTOUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF3Lkm1PFkh|ryP NXT6blZ5W0GQR1XS
RPMI-8226 NEW2Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjzcYtKSzVyPUG2MlIxPDJizszN NGTxPG9USU6JRWK=
ChaGo-K-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTNTWM2OD1zNj61N|I2KM7:TR?= MWjTRW5ITVJ?
DEL NVzSeIE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LtS2lEPTB;MU[uOlcyPyEQvF2= M4KzfnNCVkeHUh?=
GP5d M3XXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjDTWM2OD1zNz6wOVMh|ryP MoTSV2FPT0WU
COLO-668 NWHQd3B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfSbXVnUUN3ME2xO{43Ojl2IN88US=> M4TiRXNCVkeHUh?=
H9 NF7reIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXpTWM2OD1zOD6yPFM{KM7:TR?= MkDNV2FPT0WU
NKM-1 NXvsfHNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HHOmlEPTB;MUiuOVEyQSEQvF2= NWn0Sop3W0GQR1XS
KYSE-150 NVPYWG1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPiNolEUUN3ME2xPE46QTh4IN88US=> MUHTRW5ITVJ?
Daoy M1i5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j5XmlEPTB;MUmuOVY1QSEQvF2= NUfafmIzW0GQR1XS
ECC10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnXeW5wUUN3ME2yNE44PDV3IN88US=> NHPQ[IlUSU6JRWK=
A388 M{\kW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJzLkmwPVEh|ryP MWXTRW5ITVJ?
MHH-NB-11 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321W2lEPTB;MkOuNVM3OyEQvF2= MYXTRW5ITVJ?
HCC1937 MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\QOZJUUUN3ME2yOE44PDZizszN NVjTcGZnW0GQR1XS
TGBC11TKB M{PrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrV[W5KSzVyPUK1MlY5PjNizszN MV\TRW5ITVJ?
CTV-1 NW\kc4J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rtVmlEPTB;MkWuPFk3QSEQvF2= NF[1[3JUSU6JRWK=
NCI-H2029 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvsd2V3UUN3ME2yOk41OjN6IN88US=> NUP0O4t{W0GQR1XS
HLE M3fn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXZcHpKSzVyPUK3MlA2PCEQvF2= NH36R4dUSU6JRWK=
NCI-H1693 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ETWM2OD1{Nz6yPFk5KM7:TR?= M4fSWnNCVkeHUh?=
HCC70 NG\a[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm1OGhKSzVyPUK3MlczPDZizszN M1T4S3NCVkeHUh?=
BEN MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ5Lkm1OlYh|ryP NU\0NWx7W0GQR1XS
LB771 NXvXcW1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LVOmlEPTB;MkiuPFM4OyEQvF2= NHLD[ZRUSU6JRWK=
697 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rQW2lEPTB;MkmuNFI{PSEQvF2= M3T4dnNCVkeHUh?=
LU-139 NIHKR5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ7LkO3OFgh|ryP M2rVNnNCVkeHUh?=
EW-13 M4Ph[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULRR5k6UUN3ME2yPU4{QDF2IN88US=> Mk\ZV2FPT0WU
MOLT-13 NETTSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ7LkO4NVQh|ryP M4CwfHNCVkeHUh?=
L-363 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLTN5VKSzVyPUK5MlQ4QThizszN NXmyO|dXW0GQR1XS
EM-2 NVr5e2VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ7LkS5NFEh|ryP MknWV2FPT0WU
RS4-11 M2ni[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqwVppKSzVyPUOwMlQzPDFizszN MWrTRW5ITVJ?
A2780 M1y5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13s[2lEPTB;M{CuO|Q2PyEQvF2= NIK4OJRUSU6JRWK=
KU812 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN{LkO2OFIh|ryP MV\TRW5ITVJ?
COLO-684 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jyVGlEPTB;M{OuN|U6QSEQvF2= MnjjV2FPT0WU
MFE-280 M{jZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCyXGlUUUN3ME2zN{4{QDh7IN88US=> MW\TRW5ITVJ?
KG-1 MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;WXmE4UUN3ME2zN{43ODBzIN88US=> MlfJV2FPT0WU
JVM-3 NVHaXZNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;1[2lEPTB;M{WuOVg3QCEQvF2= Mk\kV2FPT0WU
MV-4-11 NV[ybnRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jlbmlEPTB;M{WuPFQ6QSEQvF2= MYrTRW5ITVJ?
LAMA-84 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi3fZJvUUN3ME2zOk44OzR3IN88US=> NF:2TGRUSU6JRWK=
MOLT-16 M3r0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjTeXBKSzVyPUO2Mlk2OiEQvF2= M4jxWnNCVkeHUh?=
H4 M170c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPwUoxKSzVyPUO3MlU3PyEQvF2= M1u0TnNCVkeHUh?=
T47D NVrFVI04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PUNmlEPTB;M{euO|AyQCEQvF2= NXzwPHlNW0GQR1XS
CAL-54 M2j5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTFSldNUUN3ME2zO{46PjZizszN NEPMWFhUSU6JRWK=
SW982 NHy3XoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD4TWM2OD1|OD6wPVk5KM7:TR?= MlfaV2FPT0WU
IGROV-1 NVvMZYdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGqxVopKSzVyPUO5MlM{ODRizszN M{\ONXNCVkeHUh?=
NB14 NEDBWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTRyLkewN|Eh|ryP NXjlSWk4W0GQR1XS
HCC1187 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3Te3VFUUN3ME20NU4zPzdzIN88US=> NEC1ZlJUSU6JRWK=
SBC-1 M{Tjemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXWTWM2OD12MT6zNFY{KM7:TR?= MVvTRW5ITVJ?
KARPAS-45 NWLVd2l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRzLkS4NVgh|ryP NFm3[3NUSU6JRWK=
MOLT-4 M{C0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rmd2lEPTB;NEKuNlU{QCEQvF2= M3u4eXNCVkeHUh?=
JVM-2 Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX0NoxFUUN3ME20Nk46OjB5IN88US=> NYS3RZBPW0GQR1XS
A4-Fuk M2LsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HPS2lEPTB;NEOuOVY6OSEQvF2= MVvTRW5ITVJ?
MDA-MB-361 NIr5c4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6yT2dKSzVyPUSzMlg1OTRizszN MWPTRW5ITVJ?
BALL-1 M4HF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjwdI9oUUN3ME20N{46PTN{IN88US=> NV;OcGE5W0GQR1XS
T98G MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR2Lki1NVch|ryP Mn\VV2FPT0WU
Mo-T M2DmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR3Lk[zPFkh|ryP NVz2TIE2W0GQR1XS
MHH-PREB-1 NWe3UnpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi4VJJvUUN3ME20OU44PTh3IN88US=> Mn\4V2FPT0WU
ALL-PO M{nUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL1cJJ5UUN3ME20O{4{PzlzIN88US=> MofyV2FPT0WU
NCI-H510A M3;1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjzeZk2UUN3ME20O{46ODN2IN88US=> NFPiS2hUSU6JRWK=
ML-2 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf2SZJKUUN3ME20PU44QDV4IN88US=> NWrxb4w{W0GQR1XS

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-AKT(S473) / p-AKT(T308) / p-ERK / p-p38; 

PubMed: 22678161     


Effects of AG-014699, AZD-2281, ABT-888, or BSI-201 on the phosphorylation status of Stat3, Akt, ERK, and p38 in MDA-MB-468, MDA-MB-231, and Cal-51 cells after 72 h of treatment

22678161
Immunofluorescence
HuR; 

PubMed: 28687616     


Immunofluorescent images of HuR (green) in MIA PaCa-2 cells treated with PARPi for 12hr. Nuclei were stained with DAPI. Magnification 40X.

BRCA1; 

PubMed: 21917757     


Effects of ABT-888 and/or bortezomib on BRCA1 and RAD51 foci formation. BRCA1 and RAD1 foci induced by ABT-888 were completely resolved in cells cotreated with bortezomib. Image acquisition was performed with an epifluorescence microscope (BX51; Olympus) and multispectral color camera (Nuance FX; CRi) with a 60× or 100× magnification lens and oil immersion.

28687616 21917757
Growth inhibition assay
Cell viability (TNBC cell lines); 

PubMed: 27880910     


BRCA-proficient TNBC cell lines were treated with veliparib in the absence and presence of dinaciclib, demonstrating reduced IC50 values in the presence of dinaciclib.

Cell viability (melanoma cells); 

PubMed: 29956724     


Dose-dependent inhibitory effect of ABT-888 on melanoma cell proliferation. Human melanoma cell lines were exposed to diluents (control; CTRL) or increasing concentrations of ABT-888 for 72 h and their viability was assessed by MTT assay. Absorbance was detected at 540 nm with a microplate reader and data were expressed as a percentage of the CTRL. Data are the means ± SD of 3 experiments performed in triplicate. Statistical significance was calculated against the CTRL (*P<0.05; **P<0.01).

27880910 29956724
In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]

Protocol

Animal Research:

[1]
+ Expand
  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
0.5% methylcellulose+0.2% Tween 80
For best results, use promptly after mixing. 		5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29
Formula

C13H16N4O
CAS No. 912444-00-9
Storage powder
in solvent
Synonyms NSC 737664

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03044795 Withdrawn Drug: Veliparib Cancer University Medical Center Groningen|AbbVie|Dutch Cancer Society November 2019 Phase 2
NCT02723864 Recruiting Drug: Veliparib + VX-970 + Cisplatin Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9 2017 Phase 1
NCT02483104 Completed Drug: veliparib|Drug: carboplatin|Drug: paclitaxel Ovarian Cancer AbbVie July 2015 Phase 1
NCT01445522 Completed Drug: ABT-888|Drug: Cyclophosphamide Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3 2008 Phase 1
NCT00649207 Completed Drug: ABT-888|Radiation: Whole Brain Radiation Therapy Brain Diseases|Brain Neoplasms|Central Nervous System Diseases|Neoplasm Metastasis|Nervous System Neoplasms AbbVie (prior sponsor Abbott)|AbbVie March 2008 Phase 1
NCT00553189 Completed Drug: ABT-888|Drug: Topotecan Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9 2007 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
selleck catalog

PARP Signaling Pathway Map

PARP Inhibitors with Unique Features

  • Selective PARP Inhibitors

    AG-14361 : PARP1-selective, Ki<5 nM.

  • Selective PARP Inhibitors

    UPF 1069 : PARP2-selective, IC50=0.3 μM.

  • Most Potent PARP Inhibitor

    MK-4827 (Niraparib) : PARP1, IC50=3.8 nM; PARP2, IC50=2.1 nM.

  • PARP Inhibitor in Clinical Trial

    Iniparib (BSI-201) : Phase III for solid tumors.

  • Newest PARP Inhibitor

    BMN 673 : Novel PARP inhibitor with IC50 of 0.58 nM. Also a potent inhibitor of PARP-2, but does not inhibit PARG and highly sensitive to PTEN mutation.

Related PARP Products

  • G007-LK New

    G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.

  • NU1025 New

    NU1025 is a potent PARP inhibitor with IC50 of 400 nM.

  • SCR7 New

    SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos.

  • Olaparib (AZD2281, Ku-0059436)

    Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1.

    Features:A potent PARP inhibitor (currently in late stage clinical trials).

  • Rucaparib (AG-014699,PF-01367338) phosphate

    Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.

    Features:The first PARP inhibitor used in clinical trials combined with temozolomide.

  • Talazoparib (BMN 673)

    Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.

    Features:Most potent and selective PARPi reported thus far.

  • Iniparib (BSI-201)

    Iniparib (BSI-201) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.

  • PJ34 HCl

    PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.

    Features:Water-soluble PARP1/2 inhibitor with >10,000-fold potentcy vs. 3-aminobenzamide (prototypical PARP inhibitor). Potential uses in cardiovascular diseases (stroke, cerebral ischemia, & myocardial ischemia).

  • AG-14361

    AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.

    Features:The 1st high-potency PARP-1 inhibitor with the specificity & in vivo activity to enhance chemotherapy and radiation therapy of human cancers.

  • A-966492

    A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

    Features:A promising, structurally diverse benzimidazole analogue that is being further characterized preclinically.

Tags: buy Veliparib (ABT-888) | Veliparib (ABT-888) supplier | purchase Veliparib (ABT-888) | Veliparib (ABT-888) cost | Veliparib (ABT-888) manufacturer | order Veliparib (ABT-888) | Veliparib (ABT-888) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID