Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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Cited by 43 Publications

10 Customer Reviews

  • Chromosomal single-strand break repair rates in the indicated RPE-1 cell lines following treatment with 50 μM H2O2 in the presence/absence of 10 μM of the PARP inhibitor (PARPi) Veliparib, as measured by alkaline comet assay. Data are the mean tail moment of 100 cells per sample per experiment and are the average (-/+SEM) of three independent experiments. Two-way ANOVA analysis between relevant genotypes is presented (ns= not significant, **= p<0.01, ***= p<0.001).

    Nature, 2017, 541(7635):87-91. Veliparib (ABT-888) purchased from Selleck.

    (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

  • OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

     

    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

  • Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • T47D breast cancer cells were pretreated with indicated concentrations of ABT-888

     

     

    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

    in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.
     
     

     

    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

  • Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.

     

     

    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

    Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.

     
     

     

    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
Targets
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 MlviT4lv[XOnIFHzd4F6 NYnqd|ZDOzBibXnu MWXJcohq[mm2aX;uJI9nKFCDUmCxJJdqfGhiRVO1NEBw\iByLkCwNkDPxE1? NFy5N2oyQTh6OEe2NC=>
Jurkat M{LQ[WtqdmG|ZTDBd5NigQ>? NWC5XVF7QTZiaB?= NFTLVlBFVVOR MlGzTY5pcWKrdHnvckBw\iCSQWLQNUBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZ4VtdCC4aXHibYxqfHlid3n0bEBGSzVyIH;mJFMh|ryP NVrTUnFvOjN6NUCxPVk>
Capan1 NYnwXohzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXSU5k4OiCq MnzDSG1UVw>? MnzZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCVmNCOiCpZX7lJI12fGG2ZXSgbJVu[W5iQ3HwZY4yKGOnbHzzJJdqfGhiSVO1NEBw\iB|OT63JO69VQ>? MWOyOFM6QDN6Mx?=
DT40 NF7mcmxEgXSxdH;4bYMhSXO|YYm= NGruSVI4OiCq NV\FZndETE2VTx?= MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBkcGmla3XuJGJTS0F{LXTl[olkcWWwdDDEWFQxKGOnbHzz M1nr[VI1QTJ{NUi3
ML-1 NXLsZW81SXCxcITveIlkKEG|c3H5 M13LNVIvPSEQvF2= MW[yOEBp MlrmSG1UVw>? M1m2THN6dmW{Z3nzeIlk[WyueTDlcohidmOnczDUVmFKVC2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDNUE0yKGOnbHzz M4f1eVI1QDl3MUO1
HCT-116 MYHLbY5ie2ViQYPzZZk> MlS3NE42KM7:TR?= Mn7sNlQhcA>? M3e5U3BCWlBiYXP0bZZqfHliZHXjdoVie2W| NWPldHZFOjNyNUSyNVM>
UM-SCC1 MWjDfZRwfG:6aXOgRZN{[Xl? MWOxNEDPxE1? MW[yOEBp NFrWUm9T\WS3Y3XzJJRp\SClZXzsJJZq[WKrbHn0fS=> NHzkdYozOTlzMk[yNC=>
FaDu NEHwSVZEgXSxdH;4bYMhSXO|YYm= M4rtc|ExKM7:TR?= M4nDZVI1KGh? NILzcoVT\WS3Y3XzJJRp\SClZXzsJJZq[WKrbHn0fS=> NV;zNGd{OjF7MUK2NlA>
PC-3 NV\Tco9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSzcm11OTBizszN M2H1[mlv\HWlZYOgZUB{cWewaX\pZ4FvfCCrbnjpZol1cW:wIHnuJINwdG:weTDmc5Ju[XSrb39CpC=> NUjrO4VxOjF3N{G5NVI>
EoL-1-cell NVvQO4llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHiZYhiUUN3ME2xMlA4QThizszN MnnGV2FPT0WU
NCI-SNU-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;4RWlJUUN3ME2zMlEzQDRzIN88US=> Mn[2V2FPT0WU
BV-173 M1TyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjqOIFLUUN3ME21MlQ2PDB7IN88US=> MmnaV2FPT0WU
HCC1806 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv4V5FKSzVyPUWuO|UyPzNizszN M1m3UHNCVkeHUh?=
COLO-680 M4Wx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\nVJpKSzVyPU[uNlE1ODZizszN NH\sO4JUSU6JRWK=
HCC2218 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TQbWlEPTB;Nz63PVcxPCEQvF2= NV;lWFNmW0GQR1XS
SK-MEL-24 NXHRdXVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrmU213UUN3ME23MlgyQTJ2IN88US=> M{GyRnNCVkeHUh?=
NCI-H720 NHfI[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnBWllKUUN3ME24MlQ{PjB|IN88US=> MmDUV2FPT0WU
KASUMI-1 NGfid3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml30TWM2OD16Lki5NlY3KM7:TR?= NF3HdmdUSU6JRWK=
HAL-01 NH;tWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTlwOEi2NkDPxE1? MnXJV2FPT0WU
CAL-33 NF3zWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrEW2pKSzVyPUGwMlQ{PCEQvF2= MV3TRW5ITVJ?
SK-MEL-1 NV35NWlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7VRYNKSzVyPUGyMlQ3PjNizszN NUnSdpVOW0GQR1XS
Ramos-2G6-4C10 M2jQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF{LkS3OVIh|ryP M1L2NHNCVkeHUh?=
KY821 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzWWo4{UUN3ME2xNk41QDVizszN MVnTRW5ITVJ?
HEC-1 NIrkeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnqSZlKSzVyPUGyMlkyQTZizszN MXHTRW5ITVJ?
SK-NEP-1 MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPtW5VjUUN3ME2xN{4yPjZizszN NX\3XYJnW0GQR1XS
MN-60 NXXKPXNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrF[3N{UUN3ME2xN{42Ozh7IN88US=> MlHRV2FPT0WU
DU-145 NIfWPGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HKd2lEPTB;MUOuPVA2OyEQvF2= MXvTRW5ITVJ?
EW-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK1c2hKSzVyPUG0MlU2PjVizszN MVjTRW5ITVJ?
OS-RC-2 NYPxdpBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;RTWM2OD1zNT65OVg6KM7:TR?= NXzJSpdNW0GQR1XS
RPMI-8226 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL2RXk{UUN3ME2xOk4zODR{IN88US=> MoPiV2FPT0WU
ChaGo-K-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrScIZXUUN3ME2xOk42OzJ3IN88US=> M{\l[nNCVkeHUh?=
DEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\1TWM2OD1zNj62O|E4KM7:TR?= NXzuXlVyW0GQR1XS
GP5d MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjue3RKSzVyPUG3MlA2OyEQvF2= M2rNeXNCVkeHUh?=
COLO-668 Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL1TWM2OD1zNz62Nlk1KM7:TR?= M2fKWnNCVkeHUh?=
H9 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF6LkK4N|Mh|ryP NYf0SZNoW0GQR1XS
NKM-1 NVTU[5R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;TelBwUUN3ME2xPE42OTF7IN88US=> NV\BNWVJW0GQR1XS
KYSE-150 NUHuUphyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVriUGtxUUN3ME2xPE46QTh4IN88US=> NYfic21nW0GQR1XS
Daoy NI\TZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jndWlEPTB;MUmuOVY1QSEQvF2= MWnTRW5ITVJ?
ECC10 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyyXGxKSzVyPUKwMlc1PTVizszN MnrOV2FPT0WU
A388 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJzLkmwPVEh|ryP NUHNdJNOW0GQR1XS
MHH-NB-11 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHqe5Q1UUN3ME2yN{4yOzZ|IN88US=> M13MOXNCVkeHUh?=
HCC1937 NFKze4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ2Lke0OkDPxE1? MWHTRW5ITVJ?
TGBC11TKB NWfwTFc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ3Lk[4OlMh|ryP NWruRXNjW0GQR1XS
CTV-1 NEfUOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nPTmlEPTB;MkWuPFk3QSEQvF2= NV:4OVY5W0GQR1XS
NCI-H2029 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1npfWlEPTB;Mk[uOFI{QCEQvF2= NHzKVItUSU6JRWK=
HLE MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDpOmZUUUN3ME2yO{4xPTRizszN M2DvVXNCVkeHUh?=
NCI-H1693 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJ5LkK4PVgh|ryP NHjOZo5USU6JRWK=
HCC70 NXeyXXVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJ5LkeyOFYh|ryP NWmzSXFCW0GQR1XS
BEN Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXW2FKSzVyPUK3Mlk2PjZizszN MmHpV2FPT0WU
LB771 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnPTWM2OD1{OD64N|c{KM7:TR?= MV3TRW5ITVJ?
697 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ7LkCyN|Uh|ryP M2nQfnNCVkeHUh?=
LU-139 M{LteWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvnW4hKSzVyPUK5MlM4PDhizszN MWXTRW5ITVJ?
EW-13 M4jJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJ7LkO4NVQh|ryP NX3yRYFrW0GQR1XS
MOLT-13 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS3TWM2OD1{OT6zPFE1KM7:TR?= MoSxV2FPT0WU
L-363 NG\XdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTtTWM2OD1{OT60O|k5KM7:TR?= MmKwV2FPT0WU
EM-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ7LkS5NFEh|ryP NVLnbZVUW0GQR1XS
RS4-11 NEDEWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGxOHNOUUN3ME2zNE41OjRzIN88US=> MmfYV2FPT0WU
A2780 NV22T3pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInCVGVKSzVyPUOwMlc1PTdizszN NW[2[XZyW0GQR1XS
KU812 M{\tXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;CPGZKSzVyPUOyMlM3PDJizszN NGe2NIJUSU6JRWK=
COLO-684 NX65RnRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13KR2lEPTB;M{OuN|U6QSEQvF2= MkDTV2FPT0WU
MFE-280 NVrj[FBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\FOW1KSzVyPUOzMlM5QDlizszN MUXTRW5ITVJ?
KG-1 NUPVZmhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{niVWlEPTB;M{OuOlAxOSEQvF2= MmrGV2FPT0WU
JVM-3 NYXVc5dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4njeGlEPTB;M{WuOVg3QCEQvF2= NVvIPYRPW0GQR1XS
MV-4-11 M2\URmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInlNoVKSzVyPUO1Mlg1QTlizszN NFvOfGtUSU6JRWK=
LAMA-84 NX\qN2w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO5[pNKSzVyPUO2Mlc{PDVizszN M1v1[XNCVkeHUh?=
MOLT-16 M33Ld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\EZWlEPTB;M{[uPVUzKM7:TR?= NIjBNGtUSU6JRWK=
H4 NWPXVW5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHJ[mNKSzVyPUO3MlU3PyEQvF2= NFTTd5FUSU6JRWK=
T47D NES5WVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQOFhKSzVyPUO3MlcxOThizszN MUXTRW5ITVJ?
CAL-54 NVvWPINHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTJZ2RKSzVyPUO3Mlk3PiEQvF2= MXHTRW5ITVJ?
SW982 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzCNFBKSzVyPUO4MlA6QThizszN M1PHcnNCVkeHUh?=
IGROV-1 NXPjZWRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTN7LkOzNFQh|ryP M3vnTnNCVkeHUh?=
NB14 M4nieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEiyW4xKSzVyPUSwMlcxOzFizszN MoHLV2FPT0WU
HCC1187 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PaTGlEPTB;NEGuNlc4OSEQvF2= M2TxeXNCVkeHUh?=
SBC-1 M3PJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvsTpRKSzVyPUSxMlMxPjNizszN MV;TRW5ITVJ?
KARPAS-45 M4LV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK3bFhKSzVyPUSxMlQ5OThizszN NYX2WolHW0GQR1XS
MOLT-4 MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTR{LkK1N|gh|ryP M4LMXXNCVkeHUh?=
JVM-2 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTR{LkmyNFch|ryP MYfTRW5ITVJ?
A4-Fuk M1fwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiyOXFKSzVyPUSzMlU3QTFizszN NYXp[IM2W0GQR1XS
MDA-MB-361 NGrXfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjIcVgxUUN3ME20N{45PDF2IN88US=> NVL2[oI6W0GQR1XS
BALL-1 NX61T|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TEfWlEPTB;NEOuPVU{OiEQvF2= MmrpV2FPT0WU
T98G M3TqNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEezb5JKSzVyPUS0Mlg2OTdizszN NV3qcGhuW0GQR1XS
Mo-T NIjJXoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr1Z3pKSzVyPUS1MlY{QDlizszN MmjpV2FPT0WU
MHH-PREB-1 NYTIXFNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnSTWM2OD12NT63OVg2KM7:TR?= NHTnc|NUSU6JRWK=
ALL-PO M{fHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO1bo42UUN3ME20O{4{PzlzIN88US=> MX\TRW5ITVJ?
NCI-H510A NETYXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR5LkmwN|Qh|ryP NGPYV2lUSU6JRWK=
ML-2 NWDvZWFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PvW2lEPTB;NEmuO|g2PiEQvF2= NI\sNGtUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]

Protocol

Animal Research:

[1]

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  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
0.5% methylcellulose+0.2% Tween 80
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29
Formula

C13H16N4O

CAS No. 912444-00-9
Storage powder
in solvent
Synonyms NSC 737664

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03400306 Not yet recruiting Cancer - Ovarian AbbVie May 10 2020 Phase 1
NCT03400306 Not yet recruiting Cancer - Ovarian AbbVie May 10 2020 Phase 1
NCT03044795 Not yet recruiting Cancer University Medical Center Groningen|AbbVie|Dutch Cancer Society November 2018 Phase 2
NCT03044795 Not yet recruiting Cancer University Medical Center Groningen|AbbVie|Dutch Cancer Society November 2018 Phase 2
NCT03581292 Recruiting Anaplastic Astrocytoma|Glioblastoma|Malignant Glioma National Cancer Institute (NCI) October 31 2018 Phase 2
NCT03581292 Recruiting Anaplastic Astrocytoma|Glioblastoma|Malignant Glioma National Cancer Institute (NCI) October 31 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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