Home Apoptosis Apoptosis related activator - Bax/Bak activator - COX inhibitor - NF-κB inhibitor Jaceosidin

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Jaceosidin Apoptosis related activator

Cat.No.S0931

Jaceosidin, a flavonoid isolated from Artemisia vestita, possesses anti-tumor and anti-proliferative activities in many cancer cells. This compound induces apoptosis, activates Bax and down-regulates Mcl-1 and c-FLIP expression. It also inhibits COX-2 expression and NF-κB activation.
Jaceosidin Apoptosis related activator Chemical Structure

Chemical Structure

Molecular Weight: 330.29

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S093101 DMSO]66 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 98.35%
98.35

Chemical Information, Storage & Stability

Molecular Weight 330.29 Formula

C17H14O7

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 18085-97-7 -- Storage of Stock Solutions

Synonyms N/A Smiles COC1=C(C=CC(=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O)O

Solubility

In vitro
Batch:

DMSO : 66 mg/mL ( (199.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
Bax [1]
Mcl-1 [1]
c-FLIP [1]
COX-2 [2]
NF-κB [2]
In vitro

This compound induces apoptosis through Bax activation and downregulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells.[1]
In vivo

Jaceosidin blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates, inhibits COX-2 expression and NF-kappaB activation, and markedly reduces TNF-alpha, IL-1beta, and prostaglandin E2 (PGE(2)) levels, also inhibits hind paw edema induced by carrageenan.[2]
References

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