Elesclomol (STA-4783)

For research use only. Not for use in humans.

Catalog No.S1052

7 publications

Elesclomol (STA-4783) Chemical Structure

Molecular Weight(MW): 400.5

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

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Selleck's Elesclomol (STA-4783) has been cited by 7 publications

4 Customer Reviews

  • BMC Genomics 2014 15(1), 263. Elesclomol (STA-4783) purchased from Selleck.

    Treatment with elesclomol inhibits cancer cell growth and induces apoptosis by increasing ROS levels. a. Cell growth of SMOV2, IGROV1, and OVCA432 ovarian cancer cells treated with elesclomol in the presence or absence of the antioxidant NAC for 72 h. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated controls.

    Oncotarget, 2016, 7(35):56933-56943. Elesclomol (STA-4783) purchased from Selleck.

  • Overexpression of GILZ favors oxidative cell death Dose-response of ROS production (HE staining) (A) or cell death (PI staining) (B) in indicated cells exposed toincreasing concentrations of elesclomol for 24 h (mean ± SD, n = 3, *p < 0.05). Alternatively, cells were treated with elesclomol for 24 h with or without pre-incubation with10 mM N-Acetyl Cysteine (NAC) for 12 h before HE staining (A) or PI staining (B) (mean ± SD, n = 3, *p < 0.05).

    Int J Biochem Cell Biol, 2017, 85:166-174. Elesclomol (STA-4783) purchased from Selleck.

    The proliferation of PC3 and LNCaP cells exposed to elesclomol at a range of concentrations for 48 h was assessed using MTT assay. Results are expressed as percentage of MTT absorbance of untreated cells at 0 h. p < .05 and p < .01 compared to untreated controls. Data are means ± SEM; n = 4.

    Int J Radiat Biol, 2017, 93(2):194-203. Elesclomol (STA-4783) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
Targets
HSP70 [1]
(Cell-free assay)
In vitro

Elesclomol significantly induces the expression of heat shock stress response genes and metallothionein genes, a signature transcription profile indicative of oxidative stress in Hs294T cells. Elesclomol (100 nM) rapidly induces Hsp70 RNA levels with a 4.8-fold increase at 1 hour and a 160-fold increase at 6 hours in Ramos Burkitt's lymphoma B cells in consistent with the intracellular ROS content which increases by 20% as early as 0.5 hour and 385% at 6 hours, and the induction of Hsp70 can be blocked by antioxidants N-acetylcysteine (NAC) and Tiron pretreatment. Elesclomol increases the number of early and late apoptotic cells with 3.7- and 11-fold through the induction of oxidative stress, which can be completely blocked by NAC, while having little effect on normal cells. [1] Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 with IC50 of 110 nM, 24 nM and 9 nM, respectively. [2] Elesclomol induces copper-dependent ROS generation and cytoxicity in yeast. Instead of working through a specific cellular protein target, Elesclomol interacts with the electron transport chain (ETC), a biologically coherent set of processes occurring in the mitochondrion, to generate high levels of ROS within the organelle and consequently cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NOS-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFy1ephKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKDNwNk\lMVA2KM7:TR?= NVj1R5piW0GQR1XS
CAL-51 cell MoT0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFv6N3dKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTJ4IH7N NEjBbJVUSU6JRWK=
ABC-1 cell MofoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWnUfYJjUW6qaXLpeIlwdiCxZjDoeY1idiCDQlOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZ3IH7N MkHLV2FPT0WU
A2780 cell M4eydmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\wZlgyUW6qaXLpeIlwdiCxZjDoeY1idiCDMke4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTl2IH7N MXXTRW5ITVJ?
ES1 cell M2jvNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHTzVJNKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|Q6KG6P M1y1enNCVkeHUh?=
HUTU-80 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH35NYNKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd7MTDuUS=> NYK3U3VDW0GQR1XS
NCI-H292 cell M{ixXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVHEbppDUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEi2JI5O NYfLR3k6W0GQR1XS
NB69 cell MmDHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkKyJI5O NWi0VpZwW0GQR1XS
ES8 cell NI\aVJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;BOpJKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|Ihdk1? NH[2coFUSU6JRWK=
BCPAP cell Mo\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml[1TY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|Qhdk1? NYLlcGRHW0GQR1XS
T-24 cell NFrmcFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3K2VGlvcGmkaYTpc44hd2ZiaIXtZY4hXC1{NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVUhdk1? M4iyUHNCVkeHUh?=
EW-16 cell MlHnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHH0XYFKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43OSCwTR?= NGTjeo1USU6JRWK=
OVCAR-5 cell NHX2OnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWPIT5NNUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56MzDuUS=> M4P3OXNCVkeHUh?=
SF126 cell M{\iZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGiybVZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PSCwTR?= NX7vTVBvW0GQR1XS
KP-4 cell Mnz4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGtRNTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkG3JI5O MVfTRW5ITVJ?
GAMG cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGdCVUdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkWxJI5O MXLTRW5ITVJ?
HOS cell NXj1fG5iT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUOgcm0> MmjoV2FPT0WU
CHL-1 cell NWjOWFZnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGNJVC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj64NUBvVQ>? MoDUV2FPT0WU
AGS cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUDV[FRQUW6qaXLpeIlwdiCxZjDoeY1idiCDR2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg3KG6P MlzZV2FPT0WU
MDA-MB-157 cell NFuxUZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2T1TmlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUKgcm0> MoTIV2FPT0WU
HSC-3 cell NGSyelNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGr6eIJKdmirYnn0bY9vKG:oIHj1cYFvKEiVQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOiCwTR?= MXLTRW5ITVJ?
CAL-72 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUDJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC15MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFIhdk1? MV;TRW5ITVJ?
NBsusSR cell M4nydWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3HoWGlvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOTNibl2= MYTTRW5ITVJ?
ES7 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILzNXZKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVkhdk1? MYrTRW5ITVJ?
H-EMC-SS cell NYDyOIZFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELtSG1KdmirYnn0bY9vKG:oIHj1cYFvKEhvRV3DMXNUKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy54ODDuUS=> MXfTRW5ITVJ?
NCI-H1703 cell NU\4VXp1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1fYSGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|A{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy54ODDuUS=> M1fwXXNCVkeHUh?=
BHT-101 cell MkDXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MljpTY5pcWKrdHnvckBw\iCqdX3hckBDUFRvMUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44OiCwTR?= NH;MdXVUSU6JRWK=
SK-OV-3 cell NXHMW49bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXaeGdrUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3PWk0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy55NTDuUS=> NVra[pVFW0GQR1XS
EW-24 cell MkTsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn;CTY5pcWKrdHnvckBw\iCqdX3hckBGXy1{NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPFMhdk1? NYTYWohrW0GQR1XS
PSN1 cell NW\z[IhOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mke5TY5pcWKrdHnvckBw\iCqdX3hckBRW05zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64OEBvVQ>? NHPibFdUSU6JRWK=
OVCAR-8 cell M4GwV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlk6KG6P NX7l[Ys2W0GQR1XS
NCI-H1563 cell NYfiW2pHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{[3V2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOVY{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zMzDuUS=> M1yzOXNCVkeHUh?=
SW756 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYqzXHpFUW6qaXLpeIlwdiCxZjDoeY1idiCVV{e1OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTNibl2= MYjTRW5ITVJ?
A375 cell MnnkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX3PZVUzUW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPCCwTR?= NUC2S4oyW0GQR1XS
Ca9-22 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEjKSIpKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOjVibl2= NWHS[ZJ7W0GQR1XS
SW1990 cell MnXJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVP2OoRMUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G5PVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjN{IH7N MkXxV2FPT0WU
ES4 cell NF75S|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3HV2xKdmirYnn0bY9vKG:oIHj1cYFvKEWVNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuN|khdk1? NGfJeJpUSU6JRWK=
HCE-T cell MlLlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUT5XJE5UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1WtWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPDVibl2= NWficm5HW0GQR1XS
MOLT-16 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPDTXZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjV|IH7N NFX1fFBUSU6JRWK=
HSC-4 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn\FTY5pcWKrdHnvckBw\iCqdX3hckBJW0NvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPEBvVQ>? MXHTRW5ITVJ?
NCI-SNU-1 cell M17K[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{m2fWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLWPOWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC56NjDuUS=> M1\ZfnNCVkeHUh?=
EW-11 cell NEXSPXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2W2NGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlkhdk1? MWnTRW5ITVJ?
HT-1080 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFT5eFhKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGwPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl7IH7N MVvTRW5ITVJ?
MES-SA/Dx5 cells MnTkR5l1d3SxeHnjbZR6KGG|c3H5 MoDTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWVUNVODL1T4OUBk\WyuczygTWM2OD13IH7N MV6yN|k{Pzl6MR?=
SW1710 cell MofsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{fJW2lvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4yPiCwTR?= M1XsSnNCVkeHUh?=
EW-1 cell NHv5fnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrsXnBCUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4zPCCwTR?= M{\m[XNCVkeHUh?=
BV-173 cell M2XzRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWfJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuN|khdk1? MXjTRW5ITVJ?
TE-8 cell MlnaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkSxJI5O M2HJdHNCVkeHUh?=
G-401 cell NVfMNpR2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPMSmdnUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPDNibl2= MXXTRW5ITVJ?
KOSC-2 cell M3H6U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3r5XGlvcGmkaYTpc44hd2ZiaIXtZY4hU0:VQz2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU41PSCwTR?= NVK5c|lnW0GQR1XS
HuCCT1 cell MoPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXDXohyUW6qaXLpeIlwdiCxZjDoeY1idiCKdVPDWFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjV{IH7N MV;TRW5ITVJ?
FADU cell M2L5bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4n0dmlvcGmkaYTpc44hd2ZiaIXtZY4hTkGGVTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuOlYhdk1? NXPrOWxZW0GQR1XS
MHH-ES-1 cell NHXXOWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2OxTGlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLVXTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjZ7IH7N NXXxbYc2W0GQR1XS
ES3 cell M{nCO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXrJcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwN{mgcm0> MX7TRW5ITVJ?
OVCAR-4 cell MofxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg4KG6P M37jSnNCVkeHUh?=
HD-MY-Z cell M4fHV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVHJcohq[mm2aX;uJI9nKGi3bXHuJGhFNU2\LWqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlkyKG6P MWjTRW5ITVJ?
human JAR cell MkPmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\IcGlvcGmkaYTpc44hd2ZiaIXtZY4hUkGUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT65O{BvVQ>? MnLjV2FPT0WU
A427 cell NGXsc5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1XQU2lvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uNFchdk1? MWHTRW5ITVJ?
697 cell M3jWSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7UTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14LkGzJI5O MojQV2FPT0WU
OVCAR-3 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlnTTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4zKG6P NVO4WnhoW0GQR1XS
human NB14 cell NGX6WnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorCTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj62OEBvVQ>? MWDTRW5ITVJ?
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COR-L105 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OMUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok44PiCwTR?= M36xV3NCVkeHUh?=
647-V cell NF;wUZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUHJcohq[mm2aX;uJI9nKGi3bXHuJFY1Py2YIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj65JI5O NIHGdVlUSU6JRWK=
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DMS-273 cell M4TFTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJGROWy1{N{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlA3KG6P NEDt[IFUSU6JRWK=
UM-UC-3 cell Mo\wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH71WoNKdmirYnn0bY9vKG:oIHj1cYFvKFWPLWXDMVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB4IH7N MkDYV2FPT0WU
HEL cell NVL2V|VLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{jtO2lvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wPEBvVQ>? MWLTRW5ITVJ?
human KU-19-19 cell NYnPdo1TT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2m4e2lvcGmkaYTpc44hd2ZiaIXtZY4hU1VvMUmtNVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB7IH7N NFvIZVBUSU6JRWK=
MC-IXC cell NULNV3QxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkP6TY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlE4KG6P MYXTRW5ITVJ?
human H4 cell M3mwSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py5{NTDuUS=> NXPpOFJoW0GQR1XS
NUGC-3 cell NVjkWFhMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XzNGlvcGmkaYTpc44hd2ZiaIXtZY4hVlWJQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4{OyCwTR?= M3HqTHNCVkeHUh?=
CHP-212 cell MnXVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml\vTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4{PCCwTR?= MoHUV2FPT0WU
human SW982 cell M3jLZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHPhflNKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{41PCCwTR?= M1X0e3NCVkeHUh?=
C-33-A cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXnN2RKdmirYnn0bY9vKG:oIHj1cYFvKENvM{OtRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPThibl2= M1:5XnNCVkeHUh?=
PC-3 cell M3LheWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXjJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15Lki5JI5O MnSyV2FPT0WU
COLO-684 cell M1\1Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zOSCwTR?= NF\4RZhUSU6JRWK=
SNU-387 cell MlHiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3i1cWlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLUO4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvPDlibl2= NYHOT2RDW0GQR1XS
U251 cell M{LkS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnqe497UW6qaXLpeIlwdiCxZjDoeY1idiCXMkWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU45PiCwTR?= NGW2UnpUSU6JRWK=
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human T47D cell NG\ye25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvGcJlqUW6qaXLpeIlwdiCxZjDoeY1idiCWNEfEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPzlibl2= NWXJU2VsW0GQR1XS
A549 cell NIXBe3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnIUHRyUW6qaXLpeIlwdiCxZjDoeY1idiCDNUS5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVkvPiCwTR?= NFeyVFBUSU6JRWK=
PC-14 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2npOWlvcGmkaYTpc44hd2ZiaIXtZY4hWENvMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE44OyCwTR?= NHXKNGVUSU6JRWK=
A704 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGE4ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Nz60OUBvVQ>? NVzFTpVQW0GQR1XS
MCF7 cell NY\DO3pMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|MT6zOkBvVQ>? MnTsV2FPT0WU
PC3 cells MUPGeY5kfGmxbjDhd5NigQ>? NF7XdJZKdmirYnn0bY9vKG:oIGDET|EudWWmaXH0[YQhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDUbJI{ODhicnXzbYR2\SCrbjDoeY1idiCSQ{OgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5zMUOg{txO NUXjcFE4OjF|NEG2O|U>
F-36P cells NITme4RRem:uaX\ldoF1cW:wIHHzd4F6 M4XLbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRj2zOnAh[2WubIOsJGlEPTB;MD6yPEDPxE1? M3\pUlIyOzRzNke1
OCI-AML2 cells MVTQdo9tcW[ncnH0bY9vKGG|c3H5 MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE:FST3BUWwzKGOnbHzzMEBKSzVyPUCuN|Uh|ryP MoTJNlE{PDF4N{W=
K562 cells NITQU2lRem:uaX\ldoF1cW:wIHHzd4F6 M4LiXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygTWM2OD1zODFOwG0> NVv0RZE1OjF|NEG2O|U>

... Click to View More Cell Line Experimental Data

In vivo Although Elesclomol (25-100 mg/kg) as a single agent shows no antitumor activity in nude mouse xenograft models of human breast cancers (MDA435, MCF7 and ZR-75-1), lung cancer (RER) or lymphoma (U937), Elesclomol substantially enhances the efficacy of chemotherapeutic agents such as paclitaxel in these models, both in terms of tumor regression and extended survival of mice. [4]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: Hs294T, HSB2, and Ramos
  • Concentrations: Dissolved in DMSO at a concentration of 10 mM, final concentrations ~500 nM
  • Incubation Time: 18, or 24 hours
  • Method: Cells are treated with various concentrations of Elesclomol for 18 or 24 hours. The level of intracellular ROS is monitored using the DCFDA probe, which emits a green fluorescence on oxidation. Cell death is determined by flow cytometry of cells double stained with Annexin V/FITC and propidium iodide (PI) using a Vybrant Apoptosis assay kit.
    (Only for Reference)
Animal Research:[4]
- Collapse
  • Animal Models: Female CD-1 nude mice bearing established MDA435 breast cancer xenograft tumors
  • Formulation: Dissolved in DMSO, and diluted in saline
  • Dosages: ~100 mg/kg
  • Administration: Intravenous injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 80 mg/mL (199.75 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40%PEG300+5%Tween80 +50%H2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 400.5
Formula

C19H20N4O2S2

CAS No. 488832-69-5
Storage powder
in solvent
Synonyms N/A
Smiles CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    How can we use the compound for in vivo mouse studies?

  • Answer:

    S1052 in 1% DMSO+30% polyethylene glycol+1% Tween 80 is a suspension, it is fine for oral administration. You can also dissolve S1052 in 0.5-1% CMC-Na solution and treat the mice by oral gavage.

HSP (e.g. HSP90) Signaling Pathway Map

Related HSP (e.g. HSP90) Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID