Mitomycin C

For research use only.

Catalog No.S8146

27 publications

Mitomycin C Chemical Structure

CAS No. 50-07-7

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

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Selleck's Mitomycin C has been cited by 27 publications

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Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
Targets
DNA synthesis [1]
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NTERA-S-cl-D1 cell MmiwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmn6TY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yNYUuODVizszN M{fOPXNCVkeHUh?=
human MOLT-4 cell NFLlUIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlP1TY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2\S1yNTFOwG0> M2H3cHNCVkeHUh?=
human J82 cell NGi0TlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfUTY5pcWKrdHnvckBw\iCqdX3hckBLQDJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkGxPUBvVQ>? NGPPUGZUSU6JRWK=
human 697 cell MkW3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;jO2xQUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4Phfg+9lCCLQ{WwQVAvOTJ6IH7N Mon4V2FPT0WU
human KYSE-510 cell MlzHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjK[nl{UW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVUyOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUS5JI5O NYTP[5VHW0GQR1XS
human NCI-H2170 cell M{\CVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHtR5Z5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyPzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG1NUBvVQ>? M2TBUXNCVkeHUh?=
human BE-13 cell NUHVeXI6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOlchdk1? M3fEdHNCVkeHUh?=
human LC-2-ad cell NVvmfWpuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYXJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1QSCwTR?= NGTNcWxUSU6JRWK=
human IMR-5 cell M1rBfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4f3dGlvcGmkaYTpc44hd2ZiaIXtZY4hUU2ULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlMxQCCwTR?= NFPNXJZUSU6JRWK=
human EW-16 cell Mn7OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlf3TY5pcWKrdHnvckBw\iCqdX3hckBGXy1zNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|Ehdk1? NIHt[ZdUSU6JRWK=
human MC-IXC cell NHTPSnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zjd2lvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43OzhizszN MVHTRW5ITVJ?
human SW872 cell M2jjfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmXhTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlc3KM7:TR?= NWfGb4tbW0GQR1XS
human NCI-H2228 cell NXziUVk2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHL6SHlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlIzQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwN{m2JO69VQ>? MoTnV2FPT0WU
K562 leukemia cells NFe3T5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXO1SIVGUW5idnn0do8hcW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEt3NkKgcIV2c2WvaXGgZ4VtdHNuIFnDOVA:OSCwTR?= MlPONVI3QTl|OE[=
human NALM-6 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO1TY5pcWKrdHnvckBw\iCqdX3hckBPSUyPLU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA4KG6P MUTTRW5ITVJ?
AA8 cells NUXMPJZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUG0JIg> MUXJcohq[mm2b4L5JIFkfGm4aYT5JI9nKGOxbYDveY5lKG[xcjDBRVgh[2WubIOgeI8hemWmdXPlJINmdGxiZHXud4l1gSCkeTC1NEUhMGW6cH;z[YQhfG9iY3;tdI92dmRiZn;yJFQhcG:3coOp NXfVZ5hGOjlyOUe0NS=>
human ES4 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmLRTY5pcWKrdHnvckBw\iCqdX3hckBGWzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW2JI5O M1HMTnNCVkeHUh?=
human KE-37 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrwS2hKdmirYnn0bY9vKG:oIHj1cYFvKEuHLUO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PCCwTR?= MVTTRW5ITVJ?
human IST-MEL1 cell M1j4O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYfGUZR5UW6qaXLpeIlwdiCxZjDoeY1idiCLU2StUWVNOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkigcm0> M3vWWXNCVkeHUh?=
human ES8 cell MnL1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{Ggcm0> NUDGSJRxW0GQR1XS
human MV-4-11 cell Ml3WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{KG6P MVnTRW5ITVJ?
human 639-V cell M{DjWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnnnTY5pcWKrdHnvckBw\iCqdX3hckA3OzlvVjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|Yhdk1? M3XKdXNCVkeHUh?=
human OCI-AML2 cell NYfPeGVtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoDlTY5pcWKrdHnvckBw\iCqdX3hckBQS0lvQV3MNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDlibl2= NWXi[XRMW0GQR1XS
human SK-LU-1 cell MnuyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4jJbmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTGWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjJibl2= Ml\LV2FPT0WU
human PSN1 cell NX;BfXduT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn74TY5pcWKrdHnvckBw\iCqdX3hckBRW05zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OUBvVQ>? MkfpV2FPT0WU
human REH cell NGHlXJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVnJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUWgcm0> NYrqVGFKW0GQR1XS
human SBC-5 cell MoPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXnVdmJ5UW6qaXLpeIlwdiCxZjDoeY1idiCVQlOtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTlibl2= NHzMO5VUSU6JRWK=
human HT-3 cell NETlb5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rtNWlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVMhdk1? MkXZV2FPT0WU
human SIG-M5 cell NVHJXZRGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGH2WndKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPTJibl2= MnGwV2FPT0WU
human ES7 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPvOmVKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOlUhdk1? NGC2VHVUSU6JRWK=
human CHP-212 cell NXzHXZZ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rjfWlvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUKxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOzdibl2= M4\RUnNCVkeHUh?=
human P12-ICHIKAWA cell NXHhVWN1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwN{mgcm0> NHy5WVFUSU6JRWK=
human HUTU-80 cell NWrBOmZtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmXMTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE45OyCwTR?= MkjlV2FPT0WU
human P30-OHK cell MkX4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1noV2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQDRibl2= MVvTRW5ITVJ?
human NCI-H1651 cell NGrL[otIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGDL[4NKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY2OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwOUmgcm0> NITTcm1USU6JRWK=
Chinese hamster V-C8 mutant cells M4fCbWN6fG:2b4jpZ:Kh[XO|YYm= M33UZlMh\GG7cx?= NIfIW5lEgXSxdH;4bYNqfHliYXfhbY5{fCCEUlPBNk1l\W[rY3nlcpQhS2irbnXz[UBp[W2|dHXyJHYuSzhibYX0ZY51KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDXV3QyKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVibl2= M2jSWVE5PTB3Mki0
human COR-L279 cell M1XPU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVLJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OMke5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU42PCCwTR?= Mn2xV2FPT0WU
human CMK cell MnrtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLOZ2lrUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg{KG6P M4\ubHNCVkeHUh?=
human MHH-CALL-2 cell NHzFS5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTWV4RKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3DRWxNNTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14LkC2JI5O MkH0V2FPT0WU
human BV-173 cell MlPXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml3mTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlA4KG6P NEXibHBUSU6JRWK=
human NCI-H209 cell M3;RbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4yPyCwTR?= NH;4dIFUSU6JRWK=
human NCI-H460 cell NGr4dnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok41PSCwTR?= MonTV2FPT0WU
human DU-145 cell NUjtOJhET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uOVIhdk1? M1TEXHNCVkeHUh?=
SW480 colon cancer cell NHnmcJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\STY4hfmm2cn:gbY5pcWKrdHnvckBw\iCVV{S4NEBkd2yxbjDjZY5k\XJiY3XscEBtcW6nLDDJR|UxRTdibl2= NWjPXFQ{OTl{MEO0PS=>
human 769-P cell M3HtRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPOTY5pcWKrdHnvckBw\iCqdX3hckA4PjlvUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNVEhdk1? M2jRSnNCVkeHUh?=
human ES1 cell M4nG[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMkmgcm0> M1zLRnNCVkeHUh?=
human COLO-668 cell M2HHc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF7uWHhKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tOlY5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py53NTDuUS=> Mmf2V2FPT0WU
human NKM-1 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N{BvVQ>? MUHTRW5ITVJ?
human ES3 cell M1rsN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4m5VWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64PEBvVQ>? NV3VPGNCW0GQR1XS
human SCC-3 cell NWLlNnl7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInpUFdKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE42OiCwTR?= NHX4[VVUSU6JRWK=
human SU-DHL-1 cell M1nkN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3zqfWlvcGmkaYTpc44hd2ZiaIXtZY4hW1VvRFjMMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjZzIH7N M3O3W3NCVkeHUh?=
human ML-2 cell NVnLXXBpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnDSpliUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE44QCCwTR?= NXPKXJlNW0GQR1XS
WiDr colon cancer cell M1vmWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIC3fGlKdiC4aYTyc{BqdmirYnn0bY9vKG:oIGfpSJIh[2:ub36gZ4Fv[2W{IHPlcIwhdGmwZTygTWM2OD1zMDDuUS=> NVP1eolEOTl{MEO0PS=>
human SF295 cell MnmyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{fVPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{OUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU41QCCwTR?= M324XHNCVkeHUh?=
human EW-7 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYH4Z|MzUW6qaXLpeIlwdiCxZjDoeY1idiCHVz23JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvOTRibl2= NFmxTY5USU6JRWK=
human H4 cell M{TOW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MontTY5pcWKrdHnvckBw\iCqdX3hckBJPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF{LkS0JI5O NXzMXpR7W0GQR1XS
human LB2241-RCC cell M{PYSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF7HV4VKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz6xPUBvVQ>? M1jLdXNCVkeHUh?=
human SR cell MmPoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLGVGNoUW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlQ3KG6P NU\GeVAzW0GQR1XS
human LB1047-RCC cell M33Pbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIi1RnVKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz62JI5O MmjsV2FPT0WU
human MCF7 cell M{PBZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3nHVWlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlkhdk1? NGnSeIhUSU6JRWK=
human ESS-1 cell MkD6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYDsVGxSUW6qaXLpeIlwdiCxZjDoeY1idiCHU2OtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl{IH7N NWHTUmlWW0GQR1XS
human NCI-H2122 cell M33OUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl4IH7N M4rFR3NCVkeHUh?=
human 786-0 cell MnHNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWfJcohq[mm2aX;uJI9nKGi3bXHuJFc5Pi1yIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuNFEh|ryP NIq3cHhUSU6JRWK=
human COLO-205 cell M1TDVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vMkC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvOzNizszN MVnTRW5ITVJ?
human HAL-01 cell M3;2VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH:3VlVKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2Njd|IN88US=> NVPTVIpnW0GQR1XS
K562 leukemia cells M1uwPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYjGN2FDUW5idnn0do8hcW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEt3NkKgcIV2c2WvaXGgZ4VtdHNiaX6geIhmKHC{ZYPlcoNmKG:oIIDkNkwhUUN3ME2xOU45KG6P NVTSfWJuOTJ4OUmzPFY>
human MHH-ES-1 cell MmjzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrsTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjJ4IH7N M2DIPXNCVkeHUh?=
human NUGC-3 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NE\yVHRKdmirYnn0bY9vKG:oIHj1cYFvKE6XR1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3Njl3IH7N MVPTRW5ITVJ?
human RPMI-8402 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE4NjF|IH7N MWXTRW5ITVJ?
human ATN-1 cell MmToS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUeuN|khdk1? MVTTRW5ITVJ?
human NCI-H441 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNESxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPiCwTR?= NX\SUo54W0GQR1XS
human LB996-RCC cell M2XqOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUT0SGF{UW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT6gTWM2OD1zNz62PEBvVQ>? MUfTRW5ITVJ?
human CAL-148 cell NICwSotIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXGyOFZsUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytNVQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwOUOgcm0> NYrOfHlSW0GQR1XS
human CTV-1 cell MkPTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrHTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG4MlY4KG6P NY\0O41XW0GQR1XS
human HOP-62 cell NGn0UGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIr1fIVKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjJibl2= M3fFeHNCVkeHUh?=
human CAKI-1 cell NWPSPFBwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF7oWnVKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{NjN{IH7N M2qxT3NCVkeHUh?=
human PA-1 cell NEnuTFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPRTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOVEhdk1? NYOzco9sW0GQR1XS
human HT-144 cell NFTGNXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Moj1TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{44PSCwTR?= MlXuV2FPT0WU
human LOUCY cell NWXHPWV3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XxTmlvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOk4yQSCwTR?= NHflTXhUSU6JRWK=
human BPH-1 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILhNplKdmirYnn0bY9vKG:oIHj1cYFvKEKSSD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvQSCwTR?= NXLhWXV6W0GQR1XS
human LS-1034 cell M3f4dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknhTY5pcWKrdHnvckBw\iCqdX3hckBNWy1zMEO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvOTZibl2= MXXTRW5ITVJ?
human 23132-87 cell MkTpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYXJcohq[mm2aX;uJI9nKGi3bXHuJFI{OTN{LUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvPTNibl2= NYDzUoh{W0GQR1XS
human BB30-HNC cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzST3o3UW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNyLk[xJI5O NVvCNo1xW0GQR1XS
human CAL-51 cell Mnj6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3z1ZWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvQDZibl2= M33GcnNCVkeHUh?=
human ALL-PO cell NYfhXWlWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOwMlk5KG6P MVvTRW5ITVJ?
human 5637 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlW3TY5pcWKrdHnvckBw\iCqdX3hckA2PjN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{GuPVMhdk1? NW\EO4d3W0GQR1XS
MCF-7 cell M1zTTWZ2dmO2aX;uJIF{e2G7 NESyUGpCdnSrdIXtc5IheG:2ZX7jfUBwdiCqdX3hckBjemWjc4SgUWNHNTdiY3XscEBtcW6nczygTWM2OD1|Mj6yJI5O NV7QUHpDOTlyNkGwPS=>
human KYSE-150 cell MnLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGt[W0VvMUWwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|QvODlibl2= NVPCVGd2W0GQR1XS
human RS4-11 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnY[opFUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PC56NjDuUS=> NHTZe29USU6JRWK=
human A3-KAW cell MlLMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzYTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOE46PiCwTR?= MlPsV2FPT0WU
human NCI-H719 cell MlSwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4GwVWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PS5zMjDuUS=> NVHxUI9{W0GQR1XS
human GI-1 cell NFTpW4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF7lfI1KdmirYnn0bY9vKG:oIHj1cYFvKEeLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOU4yPiCwTR?= M4X5dnNCVkeHUh?=
human HEL cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGhGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN3Lkigcm0> NXfB[pRjW0GQR1XS
human TE-8 cell M3qyXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkS4TY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{WuPFYhdk1? NHvxWZhUSU6JRWK=
human HT-29 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV3G[FRkUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2yPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3NjB{IH7N MYDTRW5ITVJ?
human SW1783 cell NVvEdW5MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEDZfWJKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUe4N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVM5NjV6IH7N MYjTRW5ITVJ?
human CGTH-W-1 cell M2fMVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKGi3bXHuJGNIXEhvVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9N|gvPzRibl2= MlPVV2FPT0WU
human MEL-HO cell MmnnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF3ERYZKdmirYnn0bY9vKG:oIHj1cYFvKE2HTD3IU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjRibl2= M3qzTXNCVkeHUh?=
human SW620 cell M{LCNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\EZXFKdmirYnn0bY9vKG:oIHj1cYFvKFOZNkKwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvPzlibl2= M4LwcnNCVkeHUh?=
Human Caki-1 Renal CellCarcinoma Cell NXHaVJVZTnWwY4Tpc44h[XO|YYm= MX:5OkBp M3zKfmlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IFj1cYFvKEOja3mtNUBT\W6jbDDD[YxtS2G{Y3nuc41iKEOnbHygUIlv\XNiKFPEO|AsMSCjdDC5OpRpKGixdYKsJIlkPTB;NECgcm0> NVnMcIpROTV5NEOxO|g>
human CH1 (ovarian) tumor cell NYTEOnJXS3m2b4TvfIlkyqCjc4PhfS=> MV3UbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFPINUApd3[jcnnhckkhfHWvb4KgZ4VtdCCuaX7ld{whUUN3ME20NEBvVQ>? NWjzN3dqOTB4OUi0OFQ>
human HT-29 (colon) tumor cell NWm0N3dyS3m2b4TvfIlkyqCjc4PhfS=> NHvZU|NVcGViY3;tdI92dmRid3HzJIV3[Wy3YYTl[EBnd3JidHjlJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IDjjc4xwdilidIXtc5Ih[2WubDDsbY5meyxiSVO1NF01OCCwTR?= M4jaWVExPjl6NES0
human A549 cells M1jjNmN6fG:2b4jpZ:Kh[XO|YYm= M1rFbFQ5KGh? MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;NECgcm0> MUOyOVI2QTVzNR?=
human ME-180 cell M{HucGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVztZpVjUW6qaXLpeIlwdiCxZjDoeY1idiCPRT2xPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01OC5zMTDuUS=> MX3TRW5ITVJ?
human CAL-27 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\4TY5pcWKrdHnvckBw\iCqdX3hckBESUxvMkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20NU4yQCCwTR?= NGe1OXRUSU6JRWK=
human A431 cell M1HWVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkG3TY5pcWKrdHnvckBw\iCqdX3hckBCPDNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEOuO|chdk1? MYLTRW5ITVJ?
human SW954 cell MlnQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHNYQTV2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NESuPVEhdk1? M{DsTXNCVkeHUh?=
human CAL-39 cell NV7NZ3RbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7uNW5IUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Pi52OTDuUS=> M4ns[XNCVkeHUh?=
human LU-134-A cell NEXt[IdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlP1TY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{StRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ3Njd{IH7N NVHiRnRZW0GQR1XS
human DU-4475 cell MlvsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2LLTmlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjR5IH7N M4jOcXNCVkeHUh?=
P388 cells (P388/S) cells M3fGUWZ2dmO2aX;uJIF{e2G7 NX;vN4IzTX[jbIXheIlwdiCxZjDpcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC|ZX7zbZRqfmViUEO4PEBk\WyuczCoVFM5QC:VKTDj[YxteyxiSVO1NF01QCCwTR?= M4[zcFg2PDRzOEO=
human DEL cell NXzYdWdHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnBcJRKdmirYnn0bY9vKG:oIHj1cYFvKESHTDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS4MlM6KG6P NFjTSHlUSU6JRWK=
human HGC-27 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVvVb2RLUW6qaXLpeIlwdiCxZjDoeY1idiCKR1OtNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01QS5{OTDuUS=> NV3QOZhvW0GQR1XS
human RH-1 cell MnjyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF\MbZBKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20PU42PyCwTR?= M3jDS3NCVkeHUh?=
HL-60 cells MoHqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml74TY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDD3ZZMhe3S3ZHnl[EBqdiCqdX3hckBxem:veXXsc4N6fGmlIHzleYtmdWmlIDjIUE03OCliY3XscJMtKEmFNUC9OVAhdk1? NVrvdWh6QDdyOUGxNS=>
human A2780 (ovarian) tumor cell MnWxR5l1d3SxeHnjxsBie3OjeR?= NXv3W4FNXGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBkgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjd6MDCoc5ZiemmjbjmgeJVud3JiY3XscEBtcW6nczygTWM2OD13MDDuUS=> NUO0bm1XOTB4OUi0OFQ>
human SK-MES-1 cell MkLsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVEvOTJibl2= MVfTRW5ITVJ?
human MEL-JUSO cell MmnPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW\kfHFLUW6qaXLpeIlwdiCxZjDoeY1idiCPRVytTnVUVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVzLkK1JI5O M3z3V3NCVkeHUh?=
human VA-ES-BJ cell NWnlXpRPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jWN2lvcGmkaYTpc44hd2ZiaIXtZY4hXkFvRWOtRmoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Oi5zNjDuUS=> NV;3SnRzW0GQR1XS
human EW-13 cell NXnNcoo{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHfWfGpKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVIvPTFibl2= NFzrSpNUSU6JRWK=
human Ca-Ski cell MmDwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXMNmJbUW6qaXLpeIlwdiCxZjDoeY1idiCFYT3Tb4kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Oy55NTDuUS=> NXu5ZmV5W0GQR1XS
human LXF-289 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3G4VmlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVU2NjN5IH7N NFzndGRUSU6JRWK=
human IM-9 cell NVv2RVM3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnQTIt{UW6qaXLpeIlwdiCxZjDoeY1idiCLTT25JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVYvOjJibl2= MWTTRW5ITVJ?
human HCE-4 cell NVjqfI9UT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2raSWlvcGmkaYTpc44hd2ZiaIXtZY4hUEOHLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21O{46PCCwTR?= M3X5NnNCVkeHUh?=
human TYK-nu cell NUX6R41rT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjPeIxJUW6qaXLpeIlwdiCxZjDoeY1idiCWWVutcpUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02QC55MjDuUS=> NYjMTWdOW0GQR1XS
human NCI-H748 cell NX;3VGtZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3zLbGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02QS53NDDuUS=> M1:4dHNCVkeHUh?=
human ABC-1 cell NUXUPG83T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTUVphKdmirYnn0bY9vKG:oIHj1cYFvKEGEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OlEvOiCwTR?= NXH2Tm1LW0GQR1XS
human CCRF-CEM cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OlEvPjhibl2= MVXTRW5ITVJ?
human EW-3 cell NF3kN|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnRTY5pcWKrdHnvckBw\iCqdX3hckBGXy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NkGuPVUhdk1? NEC2WFRUSU6JRWK=
human NCI-H2342 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\WNXhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlM1OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZ{LkWxJI5O NE\rclNUSU6JRWK=
human CNS cancer cells MnvxR5l1d3SxeHnjxsBie3OjeR?= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDUnMh[2GwY3XyJINmdGy|LDDHTVUxRTZ2IH7N Ml:2NVE1PzN2MUi=
human SK-PN-DW cell M1nad2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXuxXIU3UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZ|Lke2JI5O Mkj0V2FPT0WU
human EB2 cell Mn;3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGnuT|JKdmirYnn0bY9vKG:oIHj1cYFvKEWEMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBq[zVyPU[1MlM3KG6P M3vGNXNCVkeHUh?=
human HUT78 cells NUH1OZp{WHKxbHnm[ZJifGmxbjDhd5NigQ>? Ml2wOFghcA>? M2PHOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGXUO|gh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IILld4F7fXKrbjDy[YR2[3Srb36gZZN{[XluIHnjOVA:PjZibl2= NGjCPWIzPjV2MUW4Oy=>
human colon cancer cell line HCT15 M{T4cGN6fG:2b4jpZ:Kh[XO|YYm= M4P0OFczKGh? MXzJckB3cXS{bzDjfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiClb3zvckBk[W6lZYKgZ4VtdCCuaX7lJGhEXDF3IHHmeIVzKDd{IHjyJI9nKGS{dXeg[Zhxd3O3cnWg[IV1\XKvaX7l[EBjgSC2aHWgV3JDKGG|c3H5MEBKSzVyPUewJI5O NUPxcHJZOTR7OEC2O|I>
human HCT8 cells NGrUUo5EgXSxdH;4bYPDqGG|c3H5 MoTWO|IhcA>? NXnHcmVkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWODDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVg{KG6P MUmxPFg1PTR2MR?=
human THP1 cells NXrNcZJ7S3m2b4TvfIlkyqCjc4PhfS=> MnHEOFghcA>? M3jXPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHRJWDFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlEh|ryP MXWyOVI2QTVzNR?=
human PC3 cells NF\BN5lRem:uaX\ldoF1cW:wIHHzd4F6 NHvBSlA4OiCq MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhfHK7cHHuJIJtfWViZYjjcJV{cW:wIHHzd4F6NCCHQ{WwQVAvOTRizszN NF;VWWcyQTZ5NEmwOS=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PARP / Caspase 8 / Caspase 9 / Cleaved caspase-9 / Caspase 3 / Cleaved caspase-3; 

PubMed: 24901052     


LS174T cells were treated with mitomycin C (5 μg/ml) and/or rapamycin (2.5–10 μg/ml) for 24 h. After treatment, the cleavage of caspase 8, caspase 9, caspase 3, or PARP was detected by immunoblotting.

p-Akt / Akt / p-S6K / S6K / p-Jun / JNK; 

PubMed: 24901052     


LS174T cells were treated with mitomycin C (5 μg/ml) and/or rapamycin (2.5–10 μg/ml) for 24 h and p-Akt/Akt, p-S6K1/S6K1 and p-JNK/JNK were detected by immunoblotting. Actin was used to confirm the equal amount of proteins loaded in each lane.

Beclin 1 / p62 / ATG5; 

PubMed: 29142609     


(A) Beclin 1, p62 and ATG5 expression levels in T24 cells were measured by western blotting. 1 is the control, 2 MMC only, 3 MMC + 0.25 µmol/l, 4 MMC + 1 µmol/l and 5 MMC + 10 µmol/l 5-Aza-2′ deoxycitidine. GAPDH was used as an internal control. MMC: Mitomycin C

GRP78 / CHOP / Caspase-4 / Cleaved caspase-4; 

PubMed: 28553347     


(A) Dose-dependent effect of MMC on endoplasmic reticulum stress-associated proteins. Cells were treated with various concentrations of MMC (5, 10, 20 μg/mL) or phosphate buffered saline for 24 hours and immunoblot analysis was performed with antibodies specific for GRP78, Caspase-4, CHOP and GAPDH (control).

24901052 29142609 28553347
In vivo As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth. [4]

Protocol

Animal Research:[4]
- Collapse
  • Animal Models: Rat bladder tumor model
  • Dosages: 400 μM
  • Administration: Intravesical treatment
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL (197.38 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 334.37
Formula

C15H18N4O5

CAS No. 50-07-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02199327 Completed Drug: Mitomycin C|Drug: Interferon Alfa-2b Conjunctival Intraepithelial Neoplasia|Corneal Intraepithelial Neoplasia Coordinación de Investigación en Salud Mexico|Instituto Mexicano del Seguro Social|University of Guadalajara May 2014 Phase 4
NCT02015650 Terminated Drug: Cetuximab|Drug: Mitomycin-C/ 5-Fluorouracil Head and Neck Neoplasms Medical University Innsbruck April 2014 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID