Methylprednisolone (NSC-19987)

For research use only.

Licensed by Pfizer Catalog No.S1733

3 publications

Methylprednisolone (NSC-19987) Chemical Structure

CAS No. 83-43-2

Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.

Selleck's Methylprednisolone (NSC-19987) has been cited by 3 publications

1 Customer Review

  • Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.

    Trop J Pharm Res, 2014, 13 (1): 53-59.. Methylprednisolone (NSC-19987) purchased from Selleck.

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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Targets
Glucocorticoid receptor [1]
()
In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells M{[2SGZ2dmO2aX;uJIF{e2G7 M3nDWVI1KGh? MVfBZ5RqfmG2aX;uJI9nKHKjdDDQXHIh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[mG|ZXSgcJVucW6nc3PlcpQh[W6jbInzbZMtKEWFNUC9OEDPxE1? MnrsNlA6PjZyNEO=

... Click to View More Cell Line Experimental Data

In vivo

Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. [2] Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. [3] Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes. [4]

Protocol

Solubility (25°C)

In vitro DMSO 75 mg/mL (200.28 mM)
Water Insoluble
Ethanol '2 mg/mL

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Chemical Information

Molecular Weight 374.47
Formula

C22H30O5

CAS No. 83-43-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04796493 Recruiting -- Mesenteric Traction Syndrome Rigshospitalet Denmark March 11 2021 --
NCT04780581 Recruiting Drug: Dexamethasone|Drug: Methylprednisolone Corona Virus Infection Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León|Instituto de Investigación Biomédica de Salamanca February 1 2021 Phase 4
NCT04560582 Not yet recruiting Procedure: Blood Draw Kidney Transplant; Complications|Kidney Transplant Rejection|Kidney Transplant Failure University of Minnesota October 2020 --
NCT04477993 Terminated Drug: Janus Kinase Inhibitor (ruxolitinib)|Other: Placebo Severe Acute Respiratory Syndrome Coronavirus 2|SARS-CoV2 Vanderson Geraldo Rocha|University of Sao Paulo General Hospital August 14 2020 Phase 2|Phase 3
NCT04509219 Recruiting Drug: Methylprednisolone Injection Mucocutaneous Lymph Node Syndrome Chang Gung Memorial Hospital April 15 2020 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID