For research use only.

Licensed by Pfizer Catalog No.S1733 Synonyms: NSC-19987

2 publications

Methylprednisolone Chemical Structure

Molecular Weight(MW): 374.47

Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Methylprednisolone has been cited by 2 publications

1 Customer Review

  • Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.

    Trop J Pharm Res, 2014, 13 (1): 53-59.. Methylprednisolone purchased from Selleck.

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Biological Activity

Description Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.
Glucocorticoid receptor [1]
In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells NX3Rd4N7TnWwY4Tpc44h[XO|YYm= NWHzcphTOjRiaB?= M4TzWmFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF01KM7:TR?= M4nhPVIxQTZ4MESz

... Click to View More Cell Line Experimental Data

In vivo Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. [2] Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. [3] Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes. [4]


Solubility (25°C)

In vitro DMSO 75 mg/mL (200.28 mM)
Ethanol 2 mg/mL (5.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 374.47


CAS No. 83-43-2
Storage powder
in solvent
Synonyms NSC-19987
Smiles CC1CC2C3CCC(O)(C(=O)CO)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04341038 Recruiting Drug: Tacrolimus|Drug: Methylprednisolone COVID-19|Lung Injury Hospital Universitari de Bellvitge|Institut d''Investigació Biomèdica de Bellvitge April 1 2020 Phase 3
NCT04386603 Completed -- Laparoscopic Surgery|Anesthesia Shenzhen Second People''s Hospital|Shenzhen Third People''s Hospital June 1 2019 --
NCT03876444 Recruiting Drug: Intravenous Methylprednisolone|Drug: Oral Pednisolone Infantile Spasm Suvasini Sharma|Lady Hardinge Medical College April 1 2019 Phase 2|Phase 3
NCT03568136 Active not recruiting Drug: Secukinumab 300 mg|Drug: Placebo Dermatitis Atopic|Eczema Atopic|Neurodermatitis Atopic GWT-TUD GmbH|Novartis Pharmaceuticals September 18 2018 Phase 2
NCT03113695 Recruiting Drug: Obinutuzumab|Drug: lenalidomide|Drug: HDMP Richter''s Syndrome|CLL University of California San Diego December 20 2017 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID