For research use only.

Catalog No.S7076

12 publications

T0901317 Chemical Structure

CAS No. 293754-55-9

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.

Selleck's T0901317 has been cited by 12 publications

3 Customer Reviews

  • (C) Cells were pretreated with DMSO or T0901317 (5 μM), then incubated with 100 mg/L ox-LDL for 6 h.

    FEBS Lett, 2015, 589(1):52-8. . T0901317 purchased from Selleck.

    THP-1 macrophages were pretreated with 5 μg/mL T0901317 for 30 min and incubated with 100 μmol/L Hcy for 24 h. protein levels were determined.

    Life Sci, 2018, doi:10.1016/j.lfs.2018.10.060. T0901317 purchased from Selleck.

  • a Entrapment and loading efficiencies of T0901317- liposomes and anti-ICAM-1-T0901317- liposomes at two lipid to T0901317 weight ratios (5:1 and 10:1). b In vitro drug release of T0901317- liposomes (squares) and anti-ICAM-1-T0901317- liposomes (circles) at different time points. Values are expressed as the means ± SD (n = 3)

    Nanoscale Res Lett, 2017, 12(1):322. T0901317 purchased from Selleck.

Purity & Quality Control

Choose Selective Liver X Receptor Inhibitors

Biological Activity

Description T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
LXR [1]
(Cell reporter assay)
FXR [2]
50 nM(EC50) 5 μM(EC50)
In vitro

T0901317 acts through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. T0901317 upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.[1] T0901317 displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs), 10-fold more potent than natural FXR ligand chenodeoxycholic acid. [2] T0901317, is also a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. T0901317 induces expression not only of LXR target genes, but also of PXR target genes in cells and animals, including the scavenger receptor CD36. [3] T0901317 decreases amyloid-β production in primary neurons in vitro. [4] T0901317 is found to directly bind to RORα and RORγ with high affinity (Ki = 132 and 51 nM, respectively), resulting in the modulation of the receptor's ability to interact with transcriptional cofactor proteins. T0901317 represses RORα/γ-dependent transactivation of ROR-responsive reporter genes and in HepG2 cells reduces recruitment of steroid receptor coactivator-2 by RORα at an endogenous ROR target gene (G6Pase). [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
THP1 cells NGfGVnVHfW6ldHnvckBie3OjeR?= MkPlV5RqdXWuYYTpc44hd2ZiW{PIYYNpd2ync4Tldo9tKGWoZnz1fEBqdiCqdX3hckBVUFBzIH\vZY0h[2WubIOgcI9i\GWmIIfpeIgh[WNvTFTMMEBGSzVyPUOgcm0> M4HOXFE6QTZ{OEmy
COS7 cells MXPGeY5kfGmxbjDhd5NigQ>? NXvYS5N[OTZiaB?= MV7B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFzYVoJmfGFicnXj[ZB1d3JidILhcpNn\WO2ZXSgbY4hS0:VNzDj[YxteyCjZoTldkAyPiCqcoOgZpkhemWyb4L0[ZIhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTFzIH7N MkHKNVc2QDd3N{O=
CHO cells Ml7RSpVv[3Srb36gZZN{[Xl? NIPFXIxC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGxZWiCkZYThJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYomgdoVxd3K2ZYKgZZN{[XluIFXDOVA:OTZibl2= M2TqOFE6QDV|NE[y
HEK293 cells NVnPd|lHTnWwY4Tpc44h[XO|YYm= M3TjS2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gUHhT[mW2YTDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgS4FtPCC2cnHud4FkfGm4YYTpc44tKEWFNUC9NVkhdk1? NXWxd5dUOjB|NUCwNFU>
mouse J774 cells MkPYSpVv[3Srb36gZZN{[Xl? M1e4ZWFod26rc4SgZYN1cX[rdImgZZQhVFiUYnX0ZUBqdiCvb4Xz[UBLPzd2IHPlcIx{KGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCDQlPBNUBuWk6DIHX4dJJme3Orb36sJGVEPTB;MD6wNlch|ryP NHu3[oEyQTh3M{S2Ni=>
mouse J774A1 cells NVL5NohTTnWwY4Tpc44h[XO|YYm= NWjKN5pTOThiaB?= NISwNXBKdmS3Y4Tpc44hd2ZiQVLDRVEhdVKQQTDlfJBz\XO|aX;uJIlvKG2xdYPlJGo4PzSDMTDj[YxteyCjZoTldkAyQCCqcoOgZpkhWlRvUFPSMEBGSzVyPUCsNFM1KM7:TR?= MXqxPVM6PDh|Mh?=
HuH7 cells NHvTSphHfW6ldHnvckBie3OjeR?= NWTVWGo2XXC{ZXf1cIF1cW:wIH;mJHNTTUJzYzDtVm5CKGyndnXsJIlvKGi3bXHuJGh2UDdiY3XscJMtKEWFNUC9NE4xOzZizszN MVmyNFM5OjBzOR?=
HepG2 cells NInQXI1HfW6ldHnvckBie3OjeR?= M{\EU2Vn\mWldDDvckBUWkWEUEHjJIdmdmViZYjwdoV{e2mxbjDpckBpfW2jbjDI[ZBIOiClZXzsd{whTUN3ME2wMlA3OSEQvF2= NYLUNINYOTh7N{OyPFg>
SH-SY5Y cells NEe2[2RHfW6ldHnvckBie3OjeR?= MWqyOEBp NE[5T3RC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGxZWmKndHGg[ZhxemW|c3XkJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDHZYw1NUyERDDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFc2KM7:TR?= M3PqS|E6OjZ2NEix
CV1 cells NH64UI1HfW6ldHnvckBie3OjeR?= MnL5WJJidnOjY4TpeoF1cW:wIH;mJGxZWmKndHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hS1ZzIHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlE1KM7:TR?= NXrPb5hQOjV2M{WxOVE>
human H4 cells NFThb5pHfW6ldHnvckBie3OjeR?= M1ewNGVn\mWldDDvckBo[W2vYT3z[YNz\XSjc3WgZYN1cX[rdImgbY4hcHWvYX6gTFQh[2WubIOg[ZhxemW|c3nu[{BCWFB4OUWgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iQX35cI9q\CCkZYThMVQzKG[xcn3heIlwdiCOUFXDUEBie3OjeTygSWM2OD1|Lk[g{txO NFH5UHIyPzd{M{K5PC=>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
LXR-β / LXR-α ; 

PubMed: 28097086     

LXRa and LXRb protein expressions were assayed using western blot analysis.

EGFR / p-PI3K p55 / p-PI3K p85 / PI3K p85 / p-PDK1 / PDK1 ; 

PubMed: 28097086     

Western blot analysis was performed using the indicated antibodies after A549 cells were treated with 5 lM T0901317 for different days.

In vivo T0901317 treatment of 11-week-old APP23 mice for 6 days shows a significant increase in ABCA1 expression and a decrease in the ratio of soluble APP (sAPP)β- to sAPPα-cleavage products. Most importantly, the treatment causes a statistically significant reduction in the levels of soluble Aβ40 and of Aβ42 in the brain these mice. [4]


Animal Research:


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  • Animal Models: APP23 mice
  • Dosages: 50 mg/kg/day
  • Administration: gastric gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (199.44 mM)
Ethanol 96 mg/mL (199.44 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+35% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 481.33


CAS No. 293754-55-9
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
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% DMSO % % Tween 80 % ddH2O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID