Romidepsin (FK228, Depsipeptide)

Catalog No.S3020 Synonyms: FR 901228, NSC 630176

For research use only.

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

Romidepsin (FK228, Depsipeptide) Chemical Structure

CAS No. 128517-07-7

Selleck's Romidepsin (FK228, Depsipeptide) has been cited by 170 publications

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Biological Activity

Description Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
Features More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
Targets
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
In vitro

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. [1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. [2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. [3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. [5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. [6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. [7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. [9]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 NELhNZFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NWLySpFbOi53LUG1JI5O MVq3NkBp MYTpcoR2[2W|IHP5eI91d3irY3n0fUBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7lduKh NVP6PIxRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
U2932  M{XoVGNmdGxiVnnhZoltcXS7IFHzd4F6 NWPQfYVVOi53LUG1JI5O Ml;GO|IhcA>? M{nVRolv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? M1u2VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
OCI-LY7 NELhfmpE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWqyMlUuOTVibl2= MUm3NkBp Ml7pbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? M1K4UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
Farage MXPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVHOZWtFOi53LUG1JI5O NEPTOmM4OiCq NGi2SoJqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi NVfMNYJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
LY7/EBV NGS3dHFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NVvFN4lJOi53LUG1JI5O NInDUFE4OiCq MY\pcoR2[2W|IHP5eI91d3irY3n0fUBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7lduKh NEHCfYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
U2932/EBV NH\1dVBE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWmyMlUuOTVibl2= NWq5WGJXPzJiaB?= Mm\4bY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? Mnq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
HCT116 NF3rfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO3ToM2NTVyMECgcm0> NFvNZ5IzPCCq MUDEUXNQ NXKwbZN6cW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz M{LZeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOVE2Lz5{NUS5NlUyPTxxYU6=
ACH-2 MoHaSpVv[3Srb36gRZN{[Xl? NWG5cFd3OS17IH7N M3T6XlI1KGh? MUTpcoR2[2W|IFjJWk0yKEWwdjDlfJBz\XO|aX;u M2X3VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS5OFY4Lz5{NUG0PVQ3PzxxYU6=
MCF-10A M4jEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rVTWlEPTB;MD6xO:KyOC5yMTDuUS=> NXzsOIpyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
MCF-7 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv5TWM2OD1zLkGwxtExNjJyIH7N NGHVOIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SK-BR-3 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M173XGlEPTB;MT6wNOKyOC5|NTDuUS=> NYTpNYo6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
MDA-MB-231 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M365V2lEPTB;MD62POKyOC5zNDDuUS=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
PC3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fx[WlEPTB;MT62OeKyOC5|NTDuUS=> NFu0fHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
HCT116 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknSTWM2OD1zLkCwxtExNjByIH7N MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HCT116-p21-/- MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwMkdCtVAvOzdibl2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
S1 NGXMellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojyTWM2OD15Lk[3xtExNjJ7IH7N Ml\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SW620 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[1TWM2OD1yLkmzxtExNjJ7IH7N NFLvcFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
LOX-IMVI MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nqbWlEPTB;MD64O:KyOC5yMzDuUS=> M3X3V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
UACC-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwNUdCtVAvOTZibl2= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-435 NEnDW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDjTWM2OD1yLkmwxtExNjB4IH7N MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
SF-295 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwOElCtVAvOTVibl2= NHPiNmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
A549 NWGxSlJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnQW|VKSzVyPUGuNlbDuTBwMkSgcm0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
H460 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HCNGlEPTB;Mj61POKyOC56MDDuUS=> M4HPVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
EKVX M2XVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwM{RCtVAvOzRibl2= NFWyO5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H146 NUCxWmNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzxPXFKSzVyPUCuNlLDuTBwMEegcm0> NETVSGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H526 M2TSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPFTWM2OD1yLkG1xtExNjB|IH7N Mlz2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HuT-78 NX7PVY9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnnbGNiUUN3ME2xMlc{yrFyLkS0JI5O MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnHNE43OjVvMUDuUS=> NGfIToQ1QCCq MkPpbY5lfWOnczDhJJNq\26rZnnjZY51dHlic4Tyc45o\XJiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[29vdILlZZRm\CC5aYToJIJwenSnen;tbYI> Ml3QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5N{G1NVAoRjJ2N{exOVExRC:jPh?=
MS-275 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;2NE43OjVvMUDuUS=> NXHaNG86PDhiaB?= NV;CNpFzcW6mdXPld{BiKHOrZ37p[olk[W62bImgd5Rzd26pZYKgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iY3:teJJm[XSnZDD3bZRpKGKxcoTlfo9ucWJ? MoP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5N{G1NVAoRjJ2N{exOVExRC:jPh?=
CD4 T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWe0PEBp Mln5SWM2OD12LkZCtVEvOCCwTR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{MkS1OEc,OjR5MkK0OVQ9N2F-
CD4 T NFfB[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPHXnA1QCCq MX7DR|UxRTFyN9MxNVI3KG6P NFq3ZXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyNlQ2PCd-MkS3NlI1PTR:L3G+
CD4+ T MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXYeXlGSzVyPUOgcm0> NGXDc2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES5OVExPSd-MkS0PVUyODV:L3G+
A549 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jpfVEx6oDVMUCwxsBvVQ>? MViyOE8{Pi92ODDo MVzpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? M4q4SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEi1O|k6Lz5{NES4OVc6QTxxYU6=
JJN3 NYj3Z45vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:yOE81QCCq NY\w[2RETUN3MEyx5qCKdk19IES45qCKcA>? NInqRmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
OPM-2 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y4OFI1NzR6IHi= NF7IfINGSzVyc{2x5qCKdk19IES45qCKcA>? NWG2V5FKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
RPMI-8226 MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XuTVI1NzR6IHi= M1rre2VEPTC|PUGuPQKBkW6POzC0PQKBkWh? M1nKOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEOwNVUxLz5{NECzNFE2ODxxYU6=
U266 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW0NlQwPDhiaB?= NXm5O3hsTUN3MIO9NVDjiImwTUugOFjjiImq NEDqdFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
CA46 MWDBdI9xfG:|aYOgRZN{[Xl? MWK2JIg> NYH1T5lRcW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= M3\IZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
DG75 M3XSOGFxd3C2b4Ppd{BCe3OjeR?= MWe2JIg> M4rnXYlv\HWlZYOgco8h[XCxcITvd4l{ M4TFXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
Ramos MXjBdI9xfG:|aYOgRZN{[Xl? M1TuPVYhcA>? MWPpcoR2[2W|IHX4eIVve2m4ZTDhdI9xfG:|aYO= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
ST486 MlHzRZBweHSxc3nzJGF{e2G7 MVu2JIg> NVTtWVBbcW6mdXPld{BmgHSnboPpeoUh[XCxcITvd4l{ MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
HuT78 NXyyUmF6SXCxcITvd4l{KEG|c3H5 NHzQZoYyNzFyL{GwNEBvVQ>? MVy0PEBp NI\M[WlqdmS3Y3XzJIFxd3C2b4Ppd{BifCBzIH7N NWDNemlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|I4OzJpPkKzOVMzPzN{PD;hQi=>
DpVp35 NVLaW41bSXCxcITvd4l{KEG|c3H5 NVXiNnBHOS9zMD:xNFAhdk1? M3X3cFQ5KGh? NGDhe|VqdmS3Y3XzJIJtfW62IHHwc5B1d3Orcx?= NH61Tmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WzNlc{Oid-MkO1N|I4OzJ:L3G+
DpVp50 NICwWVhCeG:ydH;zbZMhSXO|YYm= M{fkbVEwOTBxMUCwJI5O NV:xW5ZOPDhiaB?= NVrkVWgycW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= M4K5S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpP75  Ml;VRZBweHSxc3nzJGF{e2G7 MX:xM|ExNzFyMDDuUS=> NHLOfJk1QCCq NV\Eb4dbcW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= NHq0dIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WzNlc{Oid-MkO1N|I4OzJ:L3G+
SKOV-3 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDRNgKBmzJybl2= MXq3NkBp MmjaSG1UVw>? MmjpdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
Brca1 WT NIjVW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW1cIYy6oDVMkDuUS=> MY[3NkBp MVTEUXNQ MmLldoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
Brca1 Null NVLGemtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPzNgKBmzJybl2= NYTZUpR7PzJiaB?= M{nxSmROW09? NVTnRZN7emWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? NHflVIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
OVCAR-8  NVnOOZVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzTNgKBmzJybl2= NEXvZXY4OiCq M1PxV2ROW09? MnrRdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> Mn7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
NCI/ADR-RES MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYWx5qCUOjCwTR?= MoDrO|IhcA>? MX\EUXNQ M{f5T5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHliYXzvcoUh[W6mIHPvcYJqdmWmIIfpeIgh[2m|cHzheIlv NUnFVm1nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
HCT116 NFuyZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjyVmZpPSCwTT21NEDPxE1? NYH5epJ3OjRiaB?= MUnEUXNQ MkW4bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{NEm1PEc,OjJ7MkS5OVg9N2F-
RKO NIHifHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjwOUBvVS13MDFOwG0> NVWxeYVlOjRiaB?= MmPtSG1UVw>? NV24NpJ5cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ? NGP0TJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
CO115 NVLTTYpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK1JI5ONTVyIN88US=> NHjrdoUzPCCq NWDpS5BxTE2VTx?= MVXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> NH3GflU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
HFS MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLHRoV7PSCwTR?= M{PYflI1NzR6L{eyJIg> M13OdolvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWt[IVx\W6mZX70cJk> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyNkK4Nkc,OjJzME[yPFI9N2F-
LNCaP NVrQenJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[1JI5O M4OzUlI1NzR6L{eyJIg> MVvpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyNkK4Nkc,OjJzME[yPFI9N2F-
A549 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7KOUBvVQ>? MWGyOE81QC95MjDo MnHmbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZT3k[ZBmdmSnboTsfS=> NX[2fIh2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
697  MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrVTWM2OOLCiU5ihKkzNjYEoH7N NX\ue216RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1N|gzOTZpPkKxOVM5OjF4PD;hQi=>
697-R NUn5WWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qxW2lEPTEkgJm95qCKQC54wrDuUeKh NV;seoJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1N|gzOTZpPkKxOVM5OjF4PD;hQi=>
HUT78 NHjqOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mybWlEPTB;MTDuUS=> NHq3THE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG5PFU1PSd-MkGxPVg2PDV:L3G+
THJ-16T M4PuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljRNUBvVQ>? NXXaNVZCOjRiaB?= MlzqbY5pcWKrdIOgZ4VtdCCpcn;3eIg> Ml\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUC1OlgoRjJyOEGwOVY5RC:jPh?=
HCT116 NUnJbGs3TnWwY4Tpc44hSXO|YYm= MU[yNEBvVQ>? NET1c5A5KGh? MkfscY9lfWyjdHXzJJRz[W6|Y4LpdJQhdGW4ZXzzJIZweiCqdX7kdoVleyCxZjDn[Y5meyCrbjDlbZRp\XJiZHny[YN1cW:w NFnNepY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEezPVQ2PCd-MkC3N|k1PTR:L3G+
B104  NITlWnlHfW6ldHnvckBCe3OjeR?= NVHQR2syOiCwTR?= NGr6eXYzPC92OD:3NkBp NF7UdpFqdmO{ZXHz[ZMhfGinIIP1doZi[2ViZYjwdoV{e2mxbjDv[kBETDJywrC= NFPsNlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OlUxPSd-MkC2PFY2ODV:L3G+
HL-60  NWHmeoVkS3m2b4TvfIlkcXS7IFHzd4F6 MVOxMVUxOCCwTR?= NULNW2JuOjRiaB?= NYXxOnhNcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MoHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HP100 NGfhOZdEgXSxdH;4bYNqfHliQYPzZZk> MVqxMVUxOCCwTR?= M2Wz[VI1KGh? NETHOY9qdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi NHTmeVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
HL-60  MlXJSpVv[3Srb36gRZN{[Xl? NGXnXlEyOCCwTR?= MXG0M|YwOTZiaB?= MVrpcoR2[2W|IITo[UBo\W6ncnH0bY9vKG:oIHj5[JJw\2WwIIDldo95cWSnIH\yc40hPGh? NHjL[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
HP100 M4nYRmZ2dmO2aX;uJGF{e2G7 NGPMNnEyOCCwTR?= NVv1fIFXPC94L{G2JIg> M1nlSolv\HWlZYOgeIhmKGenbnXyZZRqd25ib3[gbJllem:pZX6gdIVzd3irZHWg[pJwdSB2aB?= MkD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  M1zSUmZ2dmO2aX;uJGF{e2G7 MoixNVAuPTByIH7N MnXBOEBp NHHySWNl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= M2LCN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HP100 MnLGSpVv[3Srb36gRZN{[Xl? NUf0U2dZOTBvNUCwJI5O MXe0JIg> NVfVS3BK\GWlcnXhd4V{KHSqZTDobZN1d26nIHTlZYNmfHmuYYPlJEhJTEGFKTDhZ5Rqfmm2edMg M3H0N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
11z MWXLbY5ie2ViQYPzZZk> NVLQ[oFuOy1zMECgcm0> MlzqdoVlfWOnczDISGFEKGWweontZZRq[yCjY4Tpeol1gSBqSVO1NOKhRSB4LkWgxtEhOC54IH7tc4wwVCl? Mmi0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MEWxOFQoRjJyNkC1NVQ1RC:jPh?=
SKOV-3 M1HzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfNUlk1NzhxMU[gcm0> NWDuRng4PDhiaB?= MULpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> NUPs[Gp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFQ2PjRpPkKwOFA1PTZ2PD;hQi=>
OVCAR-3 M1ztWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS0M|gwOTZibl2= NVzwWFVYPDhiaB?= NFzLXmtqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? NYXncppxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFQ2PjRpPkKwOFA1PTZ2PD;hQi=>
HBL-2 M2LpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnheHBWOi1zMDDuUS=> MUWyOEBp MnnlTWM2OD12LkOgcm0> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB4OEC4NEc,OjByNkiwPFA9N2F-
Jeko-1 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vUTlIuPTBibl2= MVmyOEBp M3T4OWlEPTB;MUGgcm0> M{nTUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
Granta-519 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYK1MVQxKG6P NH;mfWMzPCCq MlLITWM2OD13OD61JI5O NYX1dnRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOlgxQDBpPkKwNFY5ODhyPD;hQi=>
L1236 NVn1b2pPS3m2b4TvfIlkcXS7IFHzd4F6 MlPaNUBvVS1zMECg{txO M3vxT|Q5KGh? MorlSWM2OD1yLkC3JO69VQ>? NIXCV2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzN|Q4OCd-MUmyN|M1PzB:L3G+
L428 NUCxRZBMS3m2b4TvfIlkcXS7IFHzd4F6 M4KxNVEhdk1vMUCwJO69VQ>? MWq0PEBp M1fOeWVEPTB;MD60N{DPxE1? NIT0UlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzN|Q4OCd-MUmyN|M1PzB:L3G+
KM-H2 NF\nNW9EgXSxdH;4bYNqfHliQYPzZZk> MVyxJI5ONTFyMDFOwG0> MVe0PEBp M3XrbmVEPTB;MD61PEDPxE1? M3zld|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L540Cy NVLOdYpIS3m2b4TvfIlkcXS7IFHzd4F6 NHvz[noyKG6PLUGwNEDPxE1? MnXyOFghcA>? NIP6UmNGSzVyPUCuNVYh|ryP M3OzdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
G401 M1uzR2Z2dmO2aX;uJGF{e2G7 NGewPJQyOCCwTR?= MkXiNlQwPDhxN{KgbC=> Mmi4SG1UVw>? NFLOcINqdmO{ZXHz[ZMhS0SNTkHDJIV5eHKnc4Ppc44> M{n1V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKxOVg3Lz5zOUKyNVU5PjxxYU6=
STM91-01 NGfHfnBHfW6ldHnvckBCe3OjeR?= NY\o[JhtOTBibl2= NGDw[WMzPC92OD:3NkBp MUXEUXNQ MX;pcoNz\WG|ZYOgR2RMVjGFIHX4dJJme3Orb36= NFXQc2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNVU5Pid-MUmyNlE2QDZ:L3G+
SJSC  Ml7FSpVv[3Srb36gRZN{[Xl? MYKxNEBvVQ>? MUmyOE81QC95MjDo NU\wTo5XTE2VTx?= M1Pu[4lv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> NEPWV409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNVU5Pid-MUmyNlE2QDZ:L3G+
BT16  MWjGeY5kfGmxbjDBd5NigQ>? MVqxNEBvVQ>? Ml\pNlQwPDhxN{KgbC=> NYrJS2ZxTE2VTx?= M2i1O4lv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
NCI-H1299 MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK4ZnlKSzVyPUSuOuKyOC5{IH7nM41t NH\6UpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-2882 NEHJeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILUbm1KSzVyPUGuOuKyOC5yNDDu[{9udA>? NYLKcW9XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
HCC95 NHfnbWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEmyNYhKSzVyPUKuOeKyOC5yNTDu[{9udA>? NX;yXlBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H23 Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn6ZmNuUUN3ME2yMlnDuTBwMjDu[{9udA>? NXziRnV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H157 NFHC[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rLVWlEPTB;MT62xtExNjB{IH7nM41t NWjqSI92RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
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mink Mv1Lu Mk\KSpVv[3Srb36gZZN{[Xl? M1LPSFI1KGi{cx?= NUL4RXZ3UW6lcnXhd4UhcW5iaIXtZY4hf2muZDD0fZBmKHB{MTDwdo91\WmwIHX4dJJme3Orb36gbY4hdWmwazDNelFNfSClZXzsd{Bi\nSncjCyOEBpenNiYomgdFIyKHC{b33veIVzKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIECuNUBuVSCmaYTobY91cHKnaYTvcEwhTUNzMECwJF0hOC5yMUW3JO69VS5? NFjG[4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5O|U4QCd-MkS5PVc2Pzh:L3G+
HCT116 M1jMUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1HOZ|Q5KGi{cx?= NGrHbmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiaX6gdJJme2WwY3Wgc4YhTFSWIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODB|IN88UU4> M1KxUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS3OlEzLz5{NUG0O|YyOjxxYU6=
MOLT4 NVW1SoNWSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MljxO|IhcHK| NV3vcY1USW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xVPCClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB{ME[g{txONg>? M2nDTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{OxN|M1Lz5{NkOzNVM{PDxxYU6=
DU145 NHPSTXZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVG3NkBpenN? NUnIUVY5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB{NUWg{txONg>? MnvoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
U937 MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{D0fVczKGi{cx?= MlztRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFM1OSEQvF2u NVLUW3MxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
HLF NUnyOXVrSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1TCU|czKGi{cx?= MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiORjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NEA:KDBwMEC0PFkh|ryPLh?= NWKzWXhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
WI38 NYOydoZLSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnjLO|IhcHK| MoXzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZSUO4JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFU{QSEQvF2u MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 NFjaboZHfW6ldHnvckBie3OjeR?= NWrYTHJiOjRiaILz M1TqPGlvcGmkaYTpc44hd2ZiSFTBR|YhcW5iaIXtZY4hXTl|NzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[WyyaHGteJVjcWyrbjDhZ4V1gWyjdHnvckBifCB3IH7NJJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
HCT116 NXvvR5h7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{PCbFczKGi{cx?= NHrNW4FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOC5yMkig{txONg>? NV[5SYFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>
IGROV1/Pt1 NYi1N3hsSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXG3NkBpenN? M12xW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSVfSU3YyN1C2MTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBkd3WudHXyJINwfW62ZYKgcYV1cG:mLDDJR|UxKD1iMD6wPEDPxE1w NIrnZZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+
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Assay
Methods Test Index PMID
Western blot p21 / Cyclin D1 ; AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27) ; HDAC3 / HDAC4 / HDAC6 / HDAC2 ; γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP ; Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac ; pAKT(S473) / pAKT(T308) / AKT 19682393 26473529 27444036 25492515
Growth inhibition assay Cell viability 27444036
Immunofluorescence SS18/TLE1 ; Cleaved caspase-3 27120803 22531354
In vivo Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. [4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). [5]

Protocol (from reference)

Kinase Assay:

[1]

  • HDAC-inhibitory activity:

    For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.

Cell Research:

[3]

  • Cell lines: HL60, Jurkat, A549, and MCF-7
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan.

  • (Only for Reference)
Animal Research:

[5]

  • Animal Models: Male scid mice inoculated i.p. with U-937 cells
  • Dosages: ~1 mg/kg once or twice a week
  • Administration: Treated i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 10 mg/mL
(18.49 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
For best results, use promptly after mixing.

5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.7
Formula

C24H36N4O6S2

CAS No. 128517-07-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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