Romidepsin (FK228, Depsipeptide)

For research use only.

Catalog No.S3020 Synonyms: FR 901228, NSC 630176

156 publications

Romidepsin (FK228, Depsipeptide) Chemical Structure

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

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Selleck's Romidepsin (FK228, Depsipeptide) has been cited by 156 publications

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Choose Selective HDAC Inhibitors

Biological Activity

Description Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
Features More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
Targets
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
In vitro

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. [1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. [2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. [3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. [5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. [6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. [7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. [9]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 NXvvfpc6S2WubDDWbYFjcWyrdImgRZN{[Xl? MVqyMlUuOTVibl2= NHqwWG04OiCq MmLPbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? NYq5fnJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
U2932  MWrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MonBNk42NTF3IH7N MYK3NkBp MUPpcoR2[2W|IHP5eI91d3irY3n0fUBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7lduKh M1TpclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
OCI-LY7 MorSR4VtdCCYaXHibYxqfHliQYPzZZk> M1HNeFIvPS1zNTDuUS=> M4TMZlczKGh? NVTGSXk6cW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= NEXqZY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
Farage MljJR4VtdCCYaXHibYxqfHliQYPzZZk> NWDQTo42Oi53LUG1JI5O NGe4ZXY4OiCq M2XYTIlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NGLwPIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
LY7/EBV NXrnToo6S2WubDDWbYFjcWyrdImgRZN{[Xl? Mkj0Nk42NTF3IH7N NE[z[WU4OiCq NW[2N2RXcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MnX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
U2932/EBV NXqwUItCS2WubDDWbYFjcWyrdImgRZN{[Xl? NEnh[GEzNjVvMUWgcm0> MkTKO|IhcA>? NVjvcYhVcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= NEf2RnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
HCT116 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13RTlUuPTByMDDuUS=> MU[yOEBp MmL1SG1UVw>? NXTt[JNLcW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NGO4cpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlUyPSd-MkW0PVI2OTV:L3G+
ACH-2 NIPLeZBHfW6ldHnvckBCe3OjeR?= NVX4foxXOS17IH7N NYnRfHFQOjRiaB?= Mme4bY5lfWOnczDITXYuOSCHbo[g[ZhxemW|c3nvci=> NVHnOIhPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxOFk1PjdpPkK1NVQ6PDZ5PD;hQi=>
MCF-10A NYfoXIRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTZTmpKSzVyPUCuNVfDuTBwMEGgcm0> NEPDXZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
MCF-7 M37Pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LWOGlEPTB;MT6xNOKyOC5{MDDuUS=> NFTnSW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SK-BR-3 M2q3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SyPGlEPTB;MT6wNOKyOC5|NTDuUS=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-231 NYLjUXN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzxN3NkUUN3ME2wMlY5yrFyLkG0JI5O M4\DeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
PC3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHJVVJKSzVyPUGuOlXDuTBwM{Wgcm0> NYTEc2NZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
HCT116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3aTWZKSzVyPUGuNFDDuTBwMECgcm0> M3;BNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116-p21-/- NE\uUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzOfXJjUUN3ME2xMlI3yrFyLkO3JI5O M2m2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
S1 NE\mbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTjTWM2OD15Lk[3xtExNjJ7IH7N MkHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SW620 M3nBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwOURCtVAvOjlibl2= MkDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
LOX-IMVI MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwOEhCtVAvODNibl2= MlntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
UACC-62 M1vTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7qTWM2OD1yLkW2xtExNjF4IH7N MnLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
MDA-MB-435 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrXS25DUUN3ME2wMlkxyrFyLkC2JI5O MkLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SF-295 NVTFWGNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\HTWM2OD1yLki4xtExNjF3IH7N NGG1bYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
A549 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFwMkdCtVAvOjRibl2= NXTuSWJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
H460 NV;GcnJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XHbmlEPTB;Mj61POKyOC56MDDuUS=> NYXMW|RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
EKVX NHLpVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXKTWM2OD1zLkOzxtExNjN2IH7N MlS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H146 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD3VW1xUUN3ME2wMlIzyrFyLkC3JI5O NHvnXnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H526 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL0R2pXUUN3ME2wMlE2yrFyLkCzJI5O NEf3cVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
HuT-78 NVvGOIlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HhO2lEPTB;MT63N:KyOC52NDDuUS=> Ml\SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HA MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\UcVAvPjJ3LUGwcm0> MYW0PEBp NF6yc3dqdmS3Y3XzJIEhe2mpbnnmbYNidnSueTDzeJJwdmencjDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiClbz30doVifGWmIIfpeIgh[m:{dHX6c41q[g>? NFHMbFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
MS-275 MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW1XXNlOC54MkWtNVBvVQ>? MofZOFghcA>? MXjpcoR2[2W|IHGgd4lodmmoaXPhcpRtgSC|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=> NHK0cYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
CD4 T NX7RSmdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYO0PEBp Mmn3SWM2OD12LkZCtVEvOCCwTR?= NUDlNo82RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NlI1PTRpPkK0O|IzPDV2PD;hQi=>
CD4 T MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\wRmE1QCCq NW\HPZVNS0N3ME2xNFfDuTF{NjDuUS=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{MkS1OEc,OjR5MkK0OVQ9N2F-
CD4+ T NXuxTlRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPT[FZvTUN3ME2zJI5O M1LRcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEm1NVA2Lz5{NES5OVExPTxxYU6=
A549 M2XUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfQUYJ{OTEkgKOxNFDDqG6P NGPIS2ozPC9|Nj:0PEBp M{PXNIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIgh[2:wY3XueJJifGmxbj2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NG\oN2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES4OVc6QSd-MkS0PFU4QTl:L3G+
JJN3 NFXLVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzwWZkzPC92ODDo NXWzSJliTUN3MEyx5qCKdk19IES45qCKcA>? NXXJVXpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
OPM-2 M1zYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnYNlQwPDhiaB?= MkX0SWM2OHN;MfMAjY5OQyB2OPMAjYg> NFvz[2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
RPMI-8226 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;PO|I1NzR6IHi= MV3FR|Uxez1zLklihKlvVTtiNElihKlp MlPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{CxOVAoRjJ2MEOwNVUxRC:jPh?=
U266 NUDafop2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrHZlAzPC92ODDo NEHnWGFGSzVyc{2xNQKBkW6POzC0PQKBkWh? Mnv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{CxOVAoRjJ2MEOwNVUxRC:jPh?=
CA46 NXLxTYZkSXCxcITvd4l{KEG|c3H5 MV:2JIg> M1\oZYlv\HWlZYOgZox2dnRiYYDvdJRwe2m| NEf5bFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
DG75 NXvqWppRSXCxcITvd4l{KEG|c3H5 MlW0OkBp NFnGbVBqdmS3Y3XzJI5wKGGyb4D0c5Nqew>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
Ramos NF[4T|FCeG:ydH;zbZMhSXO|YYm= MX:2JIg> M37nRYlv\HWlZYOg[Zh1\W6|aY\lJIFxd3C2b4Ppdy=> M2HTRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
ST486 MmfrRZBweHSxc3nzJGF{e2G7 MoPHOkBp MlTSbY5lfWOnczDlfJRmdnOrdnWgZZBweHSxc3nz MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
HuT78 MYnBdI9xfG:|aYOgRZN{[Xl? NGLXWWgyNzFyL{GwNEBvVQ>? M33vZ|Q5KGh? NWG5eIRKcW6mdXPld{BieG:ydH;zbZMh[XRiMTDuUS=> M1zvSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpVp35 NXqz[2o4SXCxcITvd4l{KEG|c3H5 NILU[4oyNzFyL{GwNEBvVQ>? NYS4SlFiPDhiaB?= M3:3W4lv\HWlZYOgZox2dnRiYYDvdJRwe2m| NIPFfZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WzNlc{Oid-MkO1N|I4OzJ:L3G+
DpVp50 MmS3RZBweHSxc3nzJGF{e2G7 MXixM|ExNzFyMDDuUS=> MkfROFghcA>? NV75cml1cW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= NHy2fXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WzNlc{Oid-MkO1N|I4OzJ:L3G+
DpP75  NYCy[3hTSXCxcITvd4l{KEG|c3H5 MlfqNU8yOC9zMECgcm0> NYTKUJY4PDhiaB?= NELlRmRqdmS3Y3XzJIJtfW62IHHwc5B1d3Orcx?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV|MkezNkc,OjN3M{K3N|I9N2F-
SKOV-3 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDJNgKBmzJybl2= NHXKO3c4OiCq MXTEUXNQ NVvtelY{emWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? NITFZpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
Brca1 WT NEOxSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLlN3Yy6oDVMkDuUS=> NVe5N|dpPzJiaB?= MoLXSG1UVw>? NI\kbVJz\WS3Y3XzJINmdGxidnnhZoltcXS7IHHsc45mKGGwZDDjc41jcW6nZDD3bZRpKGOrc4DsZZRqdg>? NW\Dd3VxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
Brca1 Null NXTiXoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jwUlHjiJN{MH7N NYfqUVBxPzJiaB?= MUjEUXNQ MYDy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> NXLrW5JrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
OVCAR-8  MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jG[|HjiJN{MH7N MWe3NkBp MnrHSG1UVw>? M4PQdJJm\HWlZYOgZ4VtdCC4aXHibYxqfHliYXzvcoUh[W6mIHPvcYJqdmWmIIfpeIgh[2m|cHzheIlv NGLkeHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
NCI/ADR-RES M4Lq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHENgKBmzJybl2= MUm3NkBp MVHEUXNQ MYLy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> NXG1Z4NbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
HCT116 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy5cHVYPSCwTT21NEDPxE1? M4\rNlI1KGh? M2m2fWROW09? M2nrTolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NXr1WJB[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlQ6PThpPkKyPVI1QTV6PD;hQi=>
RKO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUC1JI5ONTVyIN88US=> M{\xc|I1KGh? MoTLSG1UVw>? NIPTUIVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? NE\Qblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
CO115 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVS1JI5ONTVyIN88US=> MUiyOEBp NGWzRXVFVVOR M3\MdIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NYD1UVlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlQ6PThpPkKyPVI1QTV6PD;hQi=>
HFS M3\SPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHBR5pOPSCwTR?= NHKwem4zPC92OD:3NkBp MlzHbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZT3k[ZBmdmSnboTsfS=> NGLRWpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwOlI5Oid-MkKxNFYzQDJ:L3G+
LNCaP NVLsNGRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED4VnM2KG6P MXWyOE81QC95MjDo MmHZbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZT3k[ZBmdmSnboTsfS=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyNkK4Nkc,OjJzME[yPFI9N2F-
A549 NVHBWnE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLke2FkPSCwTR?= MlHyNlQwPDhxN{KgbC=> MW\pcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 MoO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzME[yPFIoRjJ{MUC2NlgzRC:jPh?=
697  MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DTfGlEPTEkgJm95qCKOi53wrDuUS=> Mo\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{iyNVYoRjJzNUO4NlE3RC:jPh?=
697-R M1zVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojDTWM2OOLCiU5ihKk5NjcEoH7NxsA> NUG5VFdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1N|gzOTZpPkKxOVM5OjF4PD;hQi=>
HUT78 NUW1eWwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK2TWM2OD1zIH7N NFK5UmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG5PFU1PSd-MkGxPVg2PDV:L3G+
THJ-16T NVr3OHd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWxNm4yKG6P MlXGNlQhcA>? M4rRWYlvcGmkaYTzJINmdGxiZ4Lve5Rp MmT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUC1OlgoRjJyOEGwOVY5RC:jPh?=
HCT116 NUTrVYw3TnWwY4Tpc44hSXO|YYm= NHTUSZIzOCCwTR?= M1H1[lghcA>? Ml;QcY9lfWyjdHXzJJRz[W6|Y4LpdJQhdGW4ZXzzJIZweiCqdX7kdoVleyCxZjDn[Y5meyCrbjDlbZRp\XJiZHny[YN1cW:w MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|OUS1OEc,OjB5M{m0OVQ9N2F-
B104  NYLsWJR2TnWwY4Tpc44hSXO|YYm= NV3oclhZOiCwTR?= NX6xNmt[OjRxNEivO|IhcA>? NXrLbWxpcW6lcnXhd4V{KHSqZTDzeZJn[WOnIHX4dJJme3Orb36gc4YhS0R{MNMg MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NkWwOUc,OjB4OE[1NFU9N2F-
HL-60  NV7TeoNMS3m2b4TvfIlkcXS7IFHzd4F6 MmL3NU02ODBibl2= MWGyOEBp M375UYlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 MonYR5l1d3SxeHnjbZR6KEG|c3H5 NYrON|A1OS13MECgcm0> MYqyOEBp Ml7KbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? MoP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  Mk\QSpVv[3Srb36gRZN{[Xl? NED6blkyOCCwTR?= Ml7tOE83NzF4IHi= NVzuSItpcW6mdXPld{B1cGViZ3Xu[ZJifGmxbjDv[kBpgWS{b3flckBx\XKxeHnk[UBnem:vIETo Mn32QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HP100 NIjLXGZHfW6ldHnvckBCe3OjeR?= MmK5NVAhdk1? M2DtSVQwPi9zNjDo M37zeolv\HWlZYOgeIhmKGenbnXyZZRqd25ib3[gbJllem:pZX6gdIVzd3irZHWg[pJwdSB2aB?= MkfOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  MYnGeY5kfGmxbjDBd5NigQ>? M1fwd|ExNTVyMDDuUS=> NGTyOJg1KGh? NEfBWG5l\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= NIGzWZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
HP100 NILr[XFHfW6ldHnvckBCe3OjeR?= MmXwNVAuPTByIH7N MWS0JIg> NH35cpRl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
11z MXjLbY5ie2ViQYPzZZk> MVOzMVExOCCwTR?= NYnocoJEemWmdXPld{BJTEGFIHXufplu[XSrYzDhZ5Rqfmm2eTCoTWM2OMLiPTC2MlUhyrFiMD62JI5ud2xxTDm= MmPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MEWxOFQoRjJyNkC1NVQ1RC:jPh?=
SKOV-3 NWLyOZhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHznZWk1NzhxMU[gcm0> M2XHRlQ5KGh? MkfibY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyNEW2OEc,OjB2MES1OlQ9N2F-
OVCAR-3 M3[5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:z[IVPPC96L{G2JI5O M4DlRVQ5KGh? NHHjNo5qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? M2TJdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEC0OVY1Lz5{MESwOFU3PDxxYU6=
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Jeko-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2yMVUxKG6P MnTBNlQhcA>? Mk\tTWM2OD1zMTDuUS=> NGnt[oI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC2PFA5OCd-MkCwOlgxQDB:L3G+
Granta-519 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfoT2o4PS12MDDuUS=> Ml\QNlQhcA>? M1S0emlEPTB;NUiuOUBvVQ>? NFv2T|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC2PFA5OCd-MkCwOlgxQDB:L3G+
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SJSC  NVTmdmdoTnWwY4Tpc44hSXO|YYm= M4TLSlExKG6P NIrpUGozPC92OD:3NkBp NWfLeW9{TE2VTx?= MX\pcoNz\WG|ZYOgR2RMVjGFIHX4dJJme3Orb36= MmjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkG1PFYoRjF7MkKxOVg3RC:jPh?=
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mink Mv1Lu M1GwTWZ2dmO2aX;uJIF{e2G7 NI[3UnkzPCCqcoO= MoP6TY5kemWjc3WgbY4hcHWvYX6ge4lt\CC2eYDlJJAzOSCycn;0[YlvKGW6cILld5Nqd25iaX6gcYlvcyCPdkHMeUBk\WyuczDh[pRmeiB{NDDodpMh[nlicEKxJJBzd22xdHXyJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDBwMTDtUUBlcXSqaX;0bJJmcXSxbDygSWMyODByIE2gNE4xOTV5IN88UU4> NV;HZ4pQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVc2PzhpPkK0PVk4PTd6PD;hQi=>
HCT116 M4DONGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXe0PEBpenN? MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gSHRVKGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFA{KM7:TT6= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF2N{[xNkc,OjVzNEe2NVI9N2F-
MOLT4 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWG3NkBpenN? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTGS0JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFIxPiEQvF2u Mn\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
DU145 M{DadGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn\qO|IhcHK| M{m4cGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlAxOjV3IN88UU4> M3\5TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{OxN|M1Lz5{NkOzNVM{PDxxYU6=
U937 Ml\0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NELNOXI4OiCqcoO= MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwN|QyKM7:TT6= MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
HLF M3fpOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnvyO|IhcHK| MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiORjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NEA:KDBwMEC0PFkh|ryPLh?= NH7C[4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
WI38 NXzJTm9nSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXi3NkBpenN? MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLM{igZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwOVM6KM7:TT6= NUfKbWg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
U937 MnXGSpVv[3Srb36gZZN{[Xl? NE[4PYozPCCqcoO= M{XCbGlvcGmkaYTpc44hd2ZiSFTBR|YhcW5iaIXtZY4hXTl|NzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[WyyaHGteJVjcWyrbjDhZ4V1gWyjdHnvckBifCB3IH7NJJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NV2wbY4xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
HCT116 NV;FSI1CSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWf4cY0{PzJiaILz MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE4xOjhizszNMi=> M{joUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEixOlU6Lz5{NkS4NVY2QTxxYU6=
IGROV1/Pt1 NWHUdmZlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmjxO|IhcHK| NVzMS3ZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJS3JQXjFxUISxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBu\XSqb3SsJGlEPTBiPTCwMlA5KM7:TT6= NYTsXJNbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>
IGROV1 NULn[otoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWi3NkBpenN? NWXQbnpnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJS3JQXjFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMkKg{txONg>? NG\GblU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
In vivo Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. [4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). [5]

Protocol

Kinase Assay:

[1]

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HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
Cell Research:

[3]

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  • Cell lines: HL60, Jurkat, A549, and MCF-7
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan.


    (Only for Reference)
Animal Research:

[5]

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  • Animal Models: Male scid mice inoculated i.p. with U-937 cells
  • Dosages: ~1 mg/kg once or twice a week
  • Administration: Treated i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.7
Formula

C24H36N4O6S2

CAS No. 128517-07-7
Storage powder
in solvent
Synonyms FR 901228, NSC 630176
Smiles CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
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    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2
NCT02296398 Completed Drug: Romidepsin Cutaneous T-cell Lymphoma Northwestern University January 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID