Romidepsin (FK228, Depsipeptide)

For research use only.

Catalog No.S3020 Synonyms: FR 901228, NSC 630176

166 publications

Romidepsin (FK228, Depsipeptide) Chemical Structure

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

Selleck's Romidepsin (FK228, Depsipeptide) has been cited by 166 publications

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Choose Selective HDAC Inhibitors

Biological Activity

Description Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
Features More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
Targets
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
In vitro

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. [1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. [2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. [3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. [5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. [6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. [7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. [9]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 M3\6TmNmdGxiVnnhZoltcXS7IFHzd4F6 NXnLcnA{Oi53LUG1JI5O MU[3NkBp NXfDSmlPcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
U2932  NFnmepdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MX6yMlUuOTVibl2= MmXhO|IhcA>? NIr6VYVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MojvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
OCI-LY7 MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2\3UVIvPS1zNTDuUS=> MonsO|IhcA>? MkXvbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? NEjPbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
Farage M2TReWNmdGxiVnnhZoltcXS7IFHzd4F6 MWiyMlUuOTVibl2= NXv6c49ZPzJiaB?= M{\Hcolv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NEjteHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
LY7/EBV MkLuR4VtdCCYaXHibYxqfHliQYPzZZk> MoC4Nk42NTF3IH7N M{\HfVczKGh? M1G2eIlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NWDkRpY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
U2932/EBV NE\RcWZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYPsOYlMOi53LUG1JI5O MmHmO|IhcA>? M3fnRolv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NH;sbYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
HCT116 NIH4[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPZd4c2NTVyMECgcm0> M16yNlI1KGh? NFPqcI5FVVOR NXLmd3RjcW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NFHIVmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlUyPSd-MkW0PVI2OTV:L3G+
ACH-2 MnTGSpVv[3Srb36gRZN{[Xl? NFnPXZEyNTlibl2= MVKyOEBp NUfxeFdmcW6mdXPld{BJUVZvMTDFcpYh\XiycnXzd4lwdg>? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF2OUS2O{c,OjVzNEm0Olc9N2F-
MCF-10A M1TSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmyNVU{UUN3ME2wMlE4yrFyLkCxJI5O M4rRO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
MCF-7 NGDHeYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLUUop7UUN3ME2xMlExyrFyLkKwJI5O NGnj[489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SK-BR-3 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwMEFCtVAvOzVibl2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-231 NWG3S4FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELLdIRKSzVyPUCuOljDuTBwMUSgcm0> M3vlN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
PC3 NVX6TGppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfWVHJKSzVyPUGuOlXDuTBwM{Wgcm0> NUTaPVZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
HCT116 MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm1TWM2OD1zLkCwxtExNjByIH7N M3XiSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116-p21-/- NH:5UXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfYW5dKSzVyPUGuNlbDuTBwM{egcm0> NH:0W5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
S1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD15Lk[3xtExNjJ7IH7N MoTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SW620 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jPdGlEPTB;MD65N:KyOC5{OTDuUS=> MnHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
LOX-IMVI Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwOEhCtVAvODNibl2= M2TMVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
UACC-62 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K5[WlEPTB;MD61OuKyOC5zNjDuUS=> MkP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
MDA-MB-435 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwOUFCtVAvODZibl2= MljDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SF-295 M2DJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDCTWM2OD1yLki4xtExNjF3IH7N MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
A549 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj2SVNKSzVyPUGuNlbDuTBwMkSgcm0> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
H460 NFLC[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXtTWM2OD1{LkW4xtExNjhyIH7N M165bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
EKVX M1vjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTQeXpKSzVyPUGuN|PDuTBwM{Sgcm0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
H146 M3zhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7jeYZ3UUN3ME2wMlIzyrFyLkC3JI5O MlrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H526 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rEcmlEPTB;MD6xOeKyOC5yMzDuUS=> M4fnNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HuT-78 NUThUmRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwN{RCtVAvPDRibl2= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HA M2rMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LUflAvPjJ3LUGwcm0> Mki0OFghcA>? MWXpcoR2[2W|IHGgd4lodmmoaXPhcpRtgSC|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=> NIe1RoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
MS-275 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT4WI1QOC54MkWtNVBvVQ>? MlLxOFghcA>? MULpcoR2[2W|IHGgd4lodmmoaXPhcpRtgSC|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=> NHXzVVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
CD4 T NHvrPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TkNVQ5KGh? NYDX[pJmTUN3ME20MlXDuTFwMDDuUS=> Mnr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkK0OVQoRjJ2N{KyOFU1RC:jPh?=
CD4 T MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWC0PEBp MYnDR|UxRTFyN9MxNVI3KG6P NYfaXJVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NlI1PTRpPkK0O|IzPDV2PD;hQi=>
CD4+ T NUKwNmo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXiNot1TUN3ME2zJI5O MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR7NUGwOUc,OjR2OUWxNFU9N2F-
A549 NXuzb|EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13CN|Ex6oDVMUCwxsBvVQ>? NIizTXIzPC9|Nj:0PEBp MXLpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MlLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OEW3PVkoRjJ2NEi1O|k6RC:jPh?=
JJN3 M4\FR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmyOE81QCCq NFXMSmJGSzVyPEJihKlvVTtiNElihKlp NY[zR|FpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
OPM-2 NFP0RopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLmNlQwPDhiaB?= MonNSWM2OHN;MfMAjY5OQyB2OPMAjYg> NV;xdmJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
RPMI-8226 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLvNlQwPDhiaB?= NVPJXGZRTUN3MIO9NU456oDLbl27JFQ56oDLaB?= MmnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{CxOVAoRjJ2MEOwNVUxRC:jPh?=
U266 NEDjcGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:yOE81QCCq NVvYXmxtTUN3MIO9NVDjiImwTUugOFjjiImq NHjMWZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
CA46 MUnBdI9xfG:|aYOgRZN{[Xl? NETG[oE3KGh? MlXmbY5lfWOnczDicJVvfCCjcH;weI9{cXN? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
DG75 M2DQ[GFxd3C2b4Ppd{BCe3OjeR?= MlrGOkBp Mo\3bY5lfWOnczDuc{BieG:ydH;zbZM> NFrhd4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
Ramos NVPUbllJSXCxcITvd4l{KEG|c3H5 MXO2JIg> NVzyVHFIcW6mdXPld{BmgHSnboPpeoUh[XCxcITvd4l{ MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
ST486 Ml\PRZBweHSxc3nzJGF{e2G7 MVi2JIg> NVfVUI9lcW6mdXPld{BmgHSnboPpeoUh[XCxcITvd4l{ NFP2XWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
HuT78 M4jSRWFxd3C2b4Ppd{BCe3OjeR?= MmDBNU8yOC9zMECgcm0> M1S3SVQ5KGh? NICxZmtqdmS3Y3XzJIFxd3C2b4Ppd{BifCBzIH7N M1fnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpVp35 MYfBdI9xfG:|aYOgRZN{[Xl? M33aRlEwOTBxMUCwJI5O NILIZYM1QCCq MkKxbY5lfWOnczDicJVvfCCjcH;weI9{cXN? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV|MkezNkc,OjN3M{K3N|I9N2F-
DpVp50 MXPBdI9xfG:|aYOgRZN{[Xl? MXixM|ExNzFyMDDuUS=> M1HvOlQ5KGh? MnrSbY5lfWOnczDicJVvfCCjcH;weI9{cXN? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV|MkezNkc,OjN3M{K3N|I9N2F-
DpP75  MVzBdI9xfG:|aYOgRZN{[Xl? M{\GVlEwOTBxMUCwJI5O NE\vZ|I1QCCq MXnpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? Mn3OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
SKOV-3 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXS[3g5OeLCk{Kwcm0> MYS3NkBp M2nU[WROW09? NHHBcllz\WS3Y3XzJINmdGxidnnhZoltcXS7IHHsc45mKGGwZDDjc41jcW6nZDD3bZRpKGOrc4DsZZRqdg>? NGPRV3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
Brca1 WT NHLzdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:x5qCUOjCwTR?= MoHjO|IhcA>? NHPpVotFVVOR MlPNdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> NUXCVZd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
Brca1 Null NHLTbHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPxNgKBmzJybl2= M1fLNFczKGh? NIG4dFVFVVOR NUPoO2U5emWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
OVCAR-8  M33PVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGx5qCUOjCwTR?= NULh[HBuPzJiaB?= M2HYTWROW09? NVnpeldOemWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? MlfzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
NCI/ADR-RES Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPOOVAy6oDVMkDuUS=> MkntO|IhcA>? NYnJOI5yTE2VTx?= NWDvemQzemWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? M{fPcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwN|Q5Lz5{M{CxNFM1QDxxYU6=
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RKO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\SOUBvVS13MDFOwG0> MojmNlQhcA>? M1TpdmROW09? NWXXZndLcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ? MlfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkS5OVgoRjJ{OUK0PVU5RC:jPh?=
CO115 NWfOZYRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjhXVU2KG6PLUWwJO69VQ>? NWrDd2hPOjRiaB?= M4\QcGROW09? MmfzbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> M4Dn[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK0PVU5Lz5{MkmyOFk2QDxxYU6=
HFS M{n1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HFcFUhdk1? NYLBS|VTOjRxNEivO|IhcA>? NFO4TopqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6 MkjwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzME[yPFIoRjJ{MUC2NlgzRC:jPh?=
LNCaP NH\adolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;QTIpFPSCwTR?= MUGyOE81QC95MjDo NInsPJRqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6 NIXaSGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwOlI5Oid-MkKxNFYzQDJ:L3G+
A549 NHXkenBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fsSVUhdk1? MlLKNlQwPDhxN{KgbC=> MkHabY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZT3k[ZBmdmSnboTsfS=> NVL0UnRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
697  MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILEcY5KSzVy4pEJQgKBkTJwNdMgcm0> NIj0OHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzPFIyPid-MkG1N|gzOTZ:L3G+
697-R NHnpXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHr[W1pUUN3MPMAjV3jiIl6LkdCpI5OyqB? MlHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{iyNVYoRjJzNUO4NlE3RC:jPh?=
HUT78 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFibl2= NH3NT5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG5PFU1PSd-MkGxPVg2PDV:L3G+
THJ-16T NETHOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjTVYsyKG6P NYm0d|NzOjRiaB?= NE\6dodqdmirYnn0d{Bk\WyuIHfyc5d1cA>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzMEW2PEc,OjB6MUC1Olg9N2F-
HCT116 MoHRSpVv[3Srb36gRZN{[Xl? NVvG[mhjOjBibl2= M1HPVVghcA>? MoPscY9lfWyjdHXzJJRz[W6|Y4LpdJQhdGW4ZXzzJIZweiCqdX7kdoVleyCxZjDn[Y5meyCrbjDlbZRp\XJiZHny[YN1cW:w M1vt[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{O5OFU1Lz5{MEezPVQ2PDxxYU6=
B104  MYPGeY5kfGmxbjDBd5NigQ>? NXLFUYJ2OiCwTR?= MXuyOE81QC95MjDo NILTcWtqdmO{ZXHz[ZMhfGinIIP1doZi[2ViZYjwdoV{e2mxbjDv[kBETDJywrC= NYjZbZlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFY2ODVpPkKwOlg3PTB3PD;hQi=>
HL-60  M4e4fWN6fG:2b4jpZ4l1gSCDc4PhfS=> NXTSXYtMOS13MECgcm0> MnXUNlQhcA>? M4joU4lv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NIDFWHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
HP100 M2\EemN6fG:2b4jpZ4l1gSCDc4PhfS=> M1nvOVEuPTByIH7N NYHjXJJqOjRiaB?= NFXM[XVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi Mm\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  M1jXN2Z2dmO2aX;uJGF{e2G7 M2\sWlExKG6P NUfxWmtKPC94L{G2JIg> MVnpcoR2[2W|IITo[UBo\W6ncnH0bY9vKG:oIHj5[JJw\2WwIIDldo95cWSnIH\yc40hPGh? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 Mnr5SpVv[3Srb36gRZN{[Xl? NEC1[IEyOCCwTR?= NVPj[GpZPC94L{G2JIg> M1HhTolv\HWlZYOgeIhmKGenbnXyZZRqd25ib3[gbJllem:pZX6gdIVzd3irZHWg[pJwdSB2aB?= M1LUeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
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HP100 NITBUVNHfW6ldHnvckBCe3OjeR?= MUOxNE02ODBibl2= NILJZXo1KGh? MX;k[YNz\WG|ZYOgeIhmKGirc4TvcoUh\GWjY3X0fYxie2ViKFjERWMqKGGldHn2bZR6yqB? M2e2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
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SKOV-3 NEXDe|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjhPVZ4PC96L{G2JI5O M1;vOlQ5KGh? M2\yfolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NVzoS3lURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFQ2PjRpPkKwOFA1PTZ2PD;hQi=>
OVCAR-3 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW5U5ZXPC96L{G2JI5O MlKxOFghcA>? Ml32bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyNEW2OEc,OjB2MES1OlQ9N2F-
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Granta-519 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLuZYU2NTRyIH7N M4nyOFI1KGh? MVLJR|UxRTV6LkWgcm0> M2nnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
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G401 M{X6c2Z2dmO2aX;uJGF{e2G7 MmTYNVAhdk1? NF;2VGczPC92OD:3NkBp MY\EUXNQ M2Dq[olv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> MnjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkG1PFYoRjF7MkKxOVg3RC:jPh?=
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NCI-2882 M{XpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnO[2VxUUN3ME2xMlbDuTBwMESgcocwdWx? NWD0PIx1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
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mink Mv1Lu NIf0SVZHfW6ldHnvckBie3OjeR?= Ml;QNlQhcHK| NHjxdFhKdmO{ZXHz[UBqdiCqdX3hckB4cWymIIT5dIUheDJzIIDyc5RmcW5iZYjwdoV{e2mxbjDpckBucW6tIF32NWx2KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDwNlEheHKxbX;0[ZIh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiMD6xJI1OKGSrdHjpc5RpemWrdH;sMEBGSzFyMECgQUAxNjBzNUeg{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7N{W3PEc,OjR7OUe1O|g9N2F-
HCT116 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFjZO5Q1QCCqcoO= MonwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGmwIIDy[ZNmdmOnIH;mJGRVXCCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlAxOyEQvF2u NGXrdGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG0O|YyOid-MkWxOFc3OTJ:L3G+
MOLT4 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWK3bWNCPzJiaILz NX[2RYdoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xVPCClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB{ME[g{txONg>? NYTIO2I2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
DU145 NVPSSIpvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFnheWc4OiCqcoO= MmLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OCB;IECuNFAzPTVizszNMi=> NXf4OXh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
U937 NWDBSmFSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Moj5O|IhcHK| NWjxbnd{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xODN2MTFOwG0v NYH3dHFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
HLF MoPVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYO3NkBpenN? MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiORjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NEA:KDBwMEC0PFkh|ryPLh?= NIX4W3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
WI38 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF3qVok4OiCqcoO= NHm4XmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGfJN|gh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlAxPTN7IN88UU4> NVXLPYRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
U937 NYTSbm8zTnWwY4Tpc44h[XO|YYm= NH7PNHkzPCCqcoO= M2HscWlvcGmkaYTpc44hd2ZiSFTBR|YhcW5iaIXtZY4hXTl|NzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[WyyaHGteJVjcWyrbjDhZ4V1gWyjdHnvckBifCB3IH7NJJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NUfWSWtJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
HCT116 NUTXRVJvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYqzNYM4PzJiaILz MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE4xOjhizszNMi=> Mo\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2OEG2OVkoRjJ4NEixOlU6RC:jPh?=
IGROV1/Pt1 NULQW4h5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3W0W|czKGi{cx?= NVuwTXU2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJS3JQXjFxUISxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBu\XSqb3SsJGlEPTBiPTCwMlA5KM7:TT6= Mnq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2OEG2OVkoRjJ4NEixOlU6RC:jPh?=
IGROV1 NXjqRotMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXThN4pIPzJiaILz MkjFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCLR2LPWlEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFAvOjJizszNMi=> NGPBfVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
In vivo Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. [4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). [5]

Protocol

Kinase Assay:

[1]

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HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
Cell Research:

[3]

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  • Cell lines: HL60, Jurkat, A549, and MCF-7
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan.


    (Only for Reference)
Animal Research:

[5]

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  • Animal Models: Male scid mice inoculated i.p. with U-937 cells
  • Dosages: ~1 mg/kg once or twice a week
  • Administration: Treated i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.7
Formula

C24H36N4O6S2

CAS No. 128517-07-7
Storage powder
in solvent
Synonyms FR 901228, NSC 630176
Smiles CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID