Home PI3K/Akt/mTOR AMPK activator - Apoptosis related inhibitor - Mitochondrial Metabolism modulator BAM 15 For research use only.

BAM 15

BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. BAM 15 is also a potent AMPK activator. BAM 15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.

BAM 15 Chemical Structure

BAM 15 Chemical Structure

CAS: 210302-17-3

Selleck's BAM 15 has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.95%
99.95

BAM 15 Related Products

Signaling Pathway

AMPK Signaling Pathways

AMPK Signaling Pathway

Choose Selective AMPK Inhibitors

Biological Activity

Description BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. BAM 15 is also a potent AMPK activator. BAM 15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Targets
AMPK [1]

Chemical Information & Solubility

Molecular Weight 340.29 Formula

C16H10F2N6O
CAS No. 210302-17-3 SDF --
Smiles C1=CC=C(C(=C1)NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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