Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 291 Publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MYnLbY5ie2ViQYPzZZk> Ml24NUBp NXfQTJNTTE2VTx?= MlXQTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP NH:2XYYyQDd3NE[1OC=>
Sf9 MVXLbY5ie2ViQYPzZZk> MVOxJIg> M1;IdmROW09? NIHweFRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NIC3R2MyQDd3NE[1OC=>
Sf9 NH\K[lVMcW6jc3WgRZN{[Xl? Mnq0NUBp NXfl[YxETE2VTx?= NWPiSnFnUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEV3NEWtT{BufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NWOzOZozOTh5NUS2OVQ>
Sf9 NUHUWXN[U2mwYYPlJGF{e2G7 MV2xJIg> NFTmbI5FVVOR NWrxRYJDUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= NVToc4tiOTh5NUS2OVQ>
Sf9 NGO0R4RMcW6jc3WgRZN{[Xl? MWmxJIg> M2fqXmROW09? M33yRmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> MUOxPFc2PDZ3NB?=
MDA-MB-361 NXzSV5B6TnWwY4Tpc44hSXO|YYm= NFjk[mMzKGh? M13OdGROW09? M1LH[2lvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvODJ6IN88US=> NX;TbYNwOTh5NUS2OVQ>
PC3 NXLFSolzTnWwY4Tpc44hSXO|YYm= MoDQNkBp MkLNSG1UVw>? NX:0d5cyUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? NVrCTo9TOTh5NUS2OVQ>
U87MG NIr1dHZHfW6ldHnvckBCe3OjeR?= NWTiXGhnOiCq MYDEUXNQ M4jFO2lvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGW4O21IKGOnbHzzJJdqfGhiSVO1NEBw\iByLkC0OkDPxE1? MUGxPFc2PDZ3NB?=
MDA-MB-361 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXZPVYhcA>? NFXOeotFVVOR MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= NUm2fVdbOTh5NUS2OVQ>
A2780 MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Hvblk3KGh? NWnUZ2YzTE2VTx?= M1zvNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOge4l1cCCSSVuzR2Eh[W6mIGDUSW4hdXW2YYTpc44hf2m2aDDJR|UxKG:oIECuNVQh|ryP NWjkfJJ7OTh5NUS2OVQ>
PC3 NGf6U3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[yPVYhcA>? NHHLbVJFVVOR NV;0eWJCUUN3ME2wMlI5KM7:TR?= Mm\3NVg4PTR4NUS=
U87MG NWi3SYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3JToV1QTZiaB?= MkfnSG1UVw>? MlHHTWM2OD1yLkm1JO69VQ>? MnrJNVg4PTR4NUS=
Sf9 NXzQcJJnU2mwYYPlJGF{e2G7 MV2zNEBucW5? NELvbXZFVVOR M{fHO2lvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NXvNSpY3OjJ3NEizOFI>
RAW 264.7 MV\LbY5ie2ViQYPzZZk> NHrzdW06OCCvaX6= MofySG1UVw>? MnG1TY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4zQThizszN MmX6NlI2PDh|NEK=
Sf9 NULOSZB[U2mwYYPlJGF{e2G7 MVOxJIg> NEnYcIxKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NHnafFUzOzV2ME[0OS=>
Sf9 NYWxfW42U2mwYYPlJGF{e2G7 M3\iR|EhcA>? MX;Jcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm MXGyN|U1ODZ2NR?=
Sf9 NFjoSHhMcW6jc3WgRZN{[Xl? NXnse5VXOSCq NV\JXHhOUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> M4DSbVI{PTRyNkS1
Sf9 MYDLbY5ie2ViQYPzZZk> MYGxJIg> MmHOTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4FteGijIHX4dJJme3OnZB?= Mk\LNlM2PDB4NEW=
SKOV3 MXrLbY5ie2ViQYPzZZk> MlnUNUDPxE1? NGPadmUyKGh? M3Luc2ROW09? M{fkeGlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25? NHj0TGozOzN4MEO0PC=>
MCF7 M3XyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP4VlgyKM7:TR?= MXe5OkBp MWPEUXNQ M{T0fmdKPTB;MD6wO|AzKM7:TR?= M{XSTVI{OzZyM{S4
SKOV3 NYLOcXN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD2eHFsOSEQvF2= MlPiPVYhcA>? Ml7FSG1UVw>? MXXHTVUxRTBwMUS3OkDPxE1? MWSyN|M3ODN2OB?=
PC3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOyO|IhcA>? M1y2RmROW09? MmroTWM2OD1yLkK4JO69VQ>? NYjEfoZKOjF7OEG3NVQ>
MCF7.1 NWjQVnY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPHfHhnPzJiaB?= NU\5TIRQTE2VTx?= MlrURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP MUOyNVk5OTdzNB?=
MCF7-neo/Her2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m3PFczKGh? MXjEUXNQ M4nTR2lEPTB;MD6yPUDPxE1? NF;EbW4zOzZ4MkmwNy=>
MCF7-neo/Her2 M2jkcmtqdmG|ZTDBd5NigQ>? NW\6[Y1UUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO NVnnWHA{OjN4NkK5NFM>
PC3 NETpO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnMO|IhcA>? MXTEUXNQ NYTVeZlbTUN3ME2wMlM1KM7:TR?= M1Xzb|IyQTh3NkO5
MCF7.1 M2H4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13BclczKGh? M335dmROW09? NXTvfIFqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigSWM2OCCxZjCwMlM6KM7:TR?= M1zheFIyQTh3NkO5
PC3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\mO|IhcA>? MnPHSG1UVw>? NGTiWppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> MYqyNFA2ODZ4OR?=
MCF7.1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XKNlczKGh? NIXEU4RFVVOR NFLpS2xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDJR|UxKG:oIECuN|Qh|ryP M3vZPVIxODVyNk[5
MCF7.1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf2b4hWPzJiaB?= NFTLUIZGSzVyPUCuO|Ih|ryP MUmyNFM1PjZ3Nh?=
NCI-H1975 NVO2T3hiS3m2b4TvfIlkKEG|c3H5 MV23NkBp MlfmTWM2OD1yLkK3JO69VQ>? NFHOeGEzOzB3OUW0OS=>
H460 NXrHfpFsS3m2b4TvfIlkKEG|c3H5 NYXufGRwPzJiaB?= MX\JR|UxRTBwOEeg{txO Mmj1NlMxPTl3NEW=
HT-29 NUTUeJhqS3m2b4TvfIlkKEG|c3H5 NED0Tmw4OiCq NVnwXXNNUUN3ME2wMlY3KM7:TR?= NVHBcIZyOjNyNUm1OFU>
HepG2 MYLDfZRwfG:6aXOgRZN{[Xl? NV\6[VY3PzJiaB?= NH3E[YZKSzVyPUGg{txO NVy2cmx7OjNyNUm1OFU>
SGC7901 NGKxRZVEgXSxdH;4bYMhSXO|YYm= MnX2O|IhcA>? MWHJR|UxRTFwODFOwG0> NWHLXZA1OjNyNUm1OFU>
NCI-H226 M1fOWGN6fG:2b4jpZ{BCe3OjeR?= Ml7oO|IhcA>? MYjJR|UxRTJwOTFOwG0> MmjRNlMxPTl3NEW=
A549 M1vM[GN6fG:2b4jpZ{BCe3OjeR?= MkXaO|IhcA>? MX3JR|UxRTZwOTFOwG0> NGHN[3czOzB3OUW0OS=>
U87MG NFTGTWREgXSxdH;4bYMhSXO|YYm= NUTjXGtVPzJiaB?= NW\ibmdlUUN3ME23Mlc4KM7:TR?= MYWyN|A2QTV2NR?=
HBC4 M3HqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XYSYxw\0eLNUC9MVYvODNiTR?= NHf3PVczOjN|NkK0Oi=>
BSY1 NWTKRopnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zXXoxw\0eLNUC9MVYvQTBiTR?= NUjMUJNWOjJ|M{[yOFY>
HBC5 M3KwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHsc4dIUTVyPT22MlYxKE1? NIPsfJYzOjN|NkK0Oi=>
MCF7 Mk\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHsc4dIUTVyPT23MlM{KE1? MnzyNlI{OzZ{NE[=
MDA-MB-231 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXsc4dIUTVyPT21MlQ3KE1? NIXhSnMzOjN|NkK0Oi=>
U251 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3sc4dIUTVyPT21MlUxKE1? NWnhNYtMOjJ|M{[yOFY>
SF268 M3z4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOyfWVtd2eJSUWwQU02NjN7IF2= NEPRbYwzOjN|NkK0Oi=>
SF295 NXX5c4N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjsc4dIUTVyPT22MlM4KE1? NVLPPFg5OjJ|M{[yOFY>
SF539 M2j2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;pcI9oT0l3ME2tOk42OCCP NFXwflYzOjN|NkK0Oi=>
SNB75 NE[1dmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDBSGltd2eJSUWwQU04NjFyIF2= NW\sZpY1OjJ|M{[yOFY>
SNB78 NIfXOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnLN5dRdG:pR1m1NF0uPi53MjDN MWmyNlM{PjJ2Nh?=
HCC2998 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;sc4dIUTVyPT22MlI6KE1? NYjKbo5sOjJ|M{[yOFY>
KM12 NFTQfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;qV4xw\0eLNUC9MVUvPzZiTR?= MVWyNlM{PjJ2Nh?=
HT-29 M1zNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P1eYxw\0eLNUC9MVYvOzBiTR?= MXSyNlM{PjJ2Nh?=
HCT15 NUPoNXVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvacI9oT0l3ME2tOk4yOiCP NWfjV3IxOjJ|M{[yOFY>
HCT116 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[zSnFtd2eJSUWwQU02Njh5IF2= MUCyNlM{PjJ2Nh?=
NCI-H23 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHjeYNtd2eJSUWwQU02Njd|IF2= M{nGSVIzOzN4MkS2
NCI-H226 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLmboRtd2eJSUWwQU03NjJzIF2= MX2yNlM{PjJ2Nh?=
NCI-H522 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPsc4dIUTVyPT22MlU5KE1? NHn4WHozOjN|NkK0Oi=>
NCI-H483 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Dy[4xw\0eLNUC9MVYvPTZiTR?= MnHMNlI{OzZ{NE[=
A549 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK4fm5td2eJSUWwQU03NjF3IF2= MonINlI{OzZ{NE[=
DMS273 NXzkfHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXvcI9oT0l3ME2tOk41OyCP MWmyNlM{PjJ2Nh?=
DMS114 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jmWIxw\0eLNUC9MVUvQTJiTR?= NI\rSYczOjN|NkK0Oi=>
LOXIMVI NWjDbmZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknWcI9oT0l3ME2tOk4zQSCP MnzsNlI{OzZ{NE[=
OVCAR3 MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHsc4dIUTVyPT22MlcyKE1? M1zvblIzOzN4MkS2
OVCAR4 NVS4WnFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG0cI9oT0l3ME2tOU44PiCP M2e5[lIzOzN4MkS2
OVCAR5 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKyNVRtd2eJSUWwQU03NjJ4IF2= NWew[GJrOjJ|M{[yOFY>
OVCAR8 NXHrbmdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\Pfoxw\0eLNUC9MVUvPzNiTR?= MlTzNlI{OzZ{NE[=
SKOV3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPKcI9oT0l3ME2tOk42OiCP NVrS[nJnOjJ|M{[yOFY>
RXF631L NEnTfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnlcI9oT0l3ME2tOk45QCCP NXLR[YFGOjJ|M{[yOFY>
ACHN NV2xfHRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHoWIZtd2eJSUWwQU03NjB5IF2= NVPwSnd5OjJ|M{[yOFY>
St-4 NW\RU2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Txd4xw\0eLNUC9MVUvPTZiTR?= MkfaNlI{OzZ{NE[=
MKN1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G3fIxw\0eLNUC9MVcvODhiTR?= MoThNlI{OzZ{NE[=
MKN7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPsc4dIUTVyPT22MlUxKE1? NYX3T4ZPOjJ|M{[yOFY>
MKN28 M3G1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTsc4dIUTVyPT21MlUzKE1? NF3z[YwzOjN|NkK0Oi=>
MKN45 NHO5eY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TRUoxw\0eLNUC9MVYvPTViTR?= M1XDWFIzOzN4MkS2
MKN74 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYSzXGM{dG:pR1m1NF0uPi5yMjDN MVqyNlM{PjJ2Nh?=
DU145 NHi4dIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;5fFRtd2eJSUWwQU02Njh3IF2= NVPBUIc2OjJ|M{[yOFY>
PC3 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfNeWRvdG:pR1m1NF0uPi54NjDN MWmyNlM{PjJ2Nh?=
ES5 NEn4TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jRNmlEPTB;NUCuNlEhdk1? Mon3V2FPT0WU
HH NFX1c|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXWTWM2OD1zMUGuNFghdk1? NGDx[opUSU6JRWK=
MHH-PREB-1 NVHqNXFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfoPXpKSzVyPUGxOE4{KG6P MkPOV2FPT0WU
NCI-H1770 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETMPVRKSzVyPUGyN{45PiCwTR?= M3XwS3NCVkeHUh?=
HuO9 NY\mToFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jVXmlEPTB;MkC2MlAzKG6P Mm\ZV2FPT0WU
HAL-01 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJyNj63N{BvVQ>? MXTTRW5ITVJ?
NOS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TYW2lEPTB;MkGxMlgzKG6P Mn;MV2FPT0WU
HGC-27 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn34TWM2OD1{MUKuOVchdk1? MXzTRW5ITVJ?
NB69 NVHMTnBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfoVYJKSzVyPUK0OU4zPyCwTR?= NGfsSHlUSU6JRWK=
RS4-11 M2Tq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XoSmlEPTB;Mk[xMlc3KG6P NXTrbVA1W0GQR1XS
DOK MoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK5TWM2OD1|MEGuO{BvVQ>? NVP2T2VKW0GQR1XS
LB2241-RCC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNyMz64OEBvVQ>? NH\rVHhUSU6JRWK=
NCI-H1623 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zGV2lEPTB;M{C0MlA5KG6P NGLxUJNUSU6JRWK=
YH-13 M3LyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonHTWM2OD1|MESuN|Ihdk1? MYXTRW5ITVJ?
BPH-1 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3KfotuUUN3ME2zNVQhdk1? NGfCN4lUSU6JRWK=
AN3-CA MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M164SmlEPTB;M{SwMlM4KG6P M1TMNnNCVkeHUh?=
ES7 NVPH[5F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTN2MT65PUBvVQ>? M4XvSXNCVkeHUh?=
MDA-MB-175-VII MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3VWZMUUN3ME2zOVIvQTJibl2= MoT0V2FPT0WU
GAMG NETEcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN5MD64OUBvVQ>? NETkZ29USU6JRWK=
CHL-1 M3v5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PPbmlEPTB;M{e4MlY2KG6P M2ftOHNCVkeHUh?=
NB7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XBWGlEPTB;M{i5Mlg{KG6P NUHBXlRjW0GQR1XS
MFE-280 M1nRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTRzOD6yJI5O MV7TRW5ITVJ?
HL-60 NHTZ[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTINVBCUUN3ME20NlUvPzVibl2= Mlm5V2FPT0WU
GCIY MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n1bmlEPTB;NEOzMlghdk1? NWW2UnJ3W0GQR1XS
MDA-MB-361 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELybZZKSzVyPUSzPU4yOyCwTR?= NFvmTlBUSU6JRWK=
LXF-289 M3z5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm2RVFKSzVyPUS0PE4zPyCwTR?= M33lW3NCVkeHUh?=
NBsusSR NF60NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu0R4lKSzVyPUS4PE45PSCwTR?= MmraV2FPT0WU
KU-19-19 NXHXVIt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVzNj6wO{BvVQ>? M13ERnNCVkeHUh?=
A204 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknETWM2OD13MkKuN|Mhdk1? MkezV2FPT0WU
LB1047-RCC Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS3R3diUUN3ME21NlIvQTNibl2= NGX4XY9USU6JRWK=
COLO-684 NELCUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTV{Mz6xNUBvVQ>? Ml:2V2FPT0WU
PA-1 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjH[FlmUUN3ME21N|IvPDFibl2= M3fRfXNCVkeHUh?=
MG-63 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LzPGlEPTB;NUSxMlEyKG6P MmLJV2FPT0WU
BHT-101 M2fGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fxcGlEPTB;NUS0Mlk1KG6P NV3W[IhXW0GQR1XS
NKM-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTV7Mz6wPUBvVQ>? MnfHV2FPT0WU
T47D MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[2WmlEPTB;NUm3MlU3KG6P NXjuWm1QW0GQR1XS
MOLT-4 M2P3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PVdGlEPTB;NkKzMlYzKG6P M2nBenNCVkeHUh?=
IGROV-1 Mk\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fwc2lEPTB;NkO0MlMyKG6P NYmyc2xnW0GQR1XS
ES4 NX62SVdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC3bYdWUUN3ME22N|kvPTRibl2= MV\TRW5ITVJ?
HuO-3N1 NWLpc29OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTZ2Mj6zPEBvVQ>? M4r1NnNCVkeHUh?=
NEC8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrOTWM2OD14NUOuOVchdk1? Mne2V2FPT0WU
HO-1-N-1 NGPX[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfETWM2OD14NUmuNVchdk1? NHnZSYFUSU6JRWK=
EPCL-272H MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfYcWRsUUN3ME22PFcvOjFibl2= MV3TRW5ITVJ?
D-263MG NH3xcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;HTWM2OD15MUiuNUBvVQ>? MUfTRW5ITVJ?
MV-4-11 NEDzeW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjlTlRMUUN3ME23NlQvOzFibl2= MUTTRW5ITVJ?
SK-NEP-1 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPPc3c6UUN3ME23NlUvQTRibl2= NUDoTpJWW0GQR1XS
SW872 MnjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PPV2lEPTB;N{K3Mlg6KG6P NXnTcotRW0GQR1XS
P30-OHK MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj4[3NKSzVyPUezNE44OSCwTR?= M2DIe3NCVkeHUh?=
OMC-1 M3TsNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3ZWVRGUUN3ME23OVEvODlibl2= MW\TRW5ITVJ?
LoVo NX\mPWNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofXTWM2OD15N{euPUBvVQ>? MWPTRW5ITVJ?
LNCaP-Clone-FGC NXrqbpNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjucYV1UUN3ME23PVYvOzRibl2= M{\WO3NCVkeHUh?=
L-363 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXEdG9JUUN3ME23PVgvPDJibl2= NYC5SIx{W0GQR1XS
ES8 NIjLN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln5TWM2OD16MUCuOVIhdk1? NGTWNlZUSU6JRWK=
697 NGDzb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrjTmtKSzVyPUizNU42PSCwTR?= MmnKV2FPT0WU
HSC-3 NXOyXVQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[3b2lEPTB;OEO5MlU1KG6P NILTenRUSU6JRWK=
H4 NFuzOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7CR2VKSzVyPUi1NE45PSCwTR?= NVrUfYxtW0GQR1XS
QIMR-WIL NY\Qd44zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LIV2lEPTB;OE[1MlIhdk1? M2L3T3NCVkeHUh?=
OAW-42 M1PKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\L[2lEPTB;OEeyMlE6KG6P MWXTRW5ITVJ?
MCF7 M2nETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPCTotxUUN3ME24PVgvPTlibl2= MlXkV2FPT0WU
SCC-25 M2HaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTlzND6xPUBvVQ>? NXPD[3FpW0GQR1XS
NCI-H1563 NHqzS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX2TWM2OD17MUWuPVkhdk1? NIHTZ5FUSU6JRWK=
OVCAR-5 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrCOYVsUUN3ME25OFAvOTdibl2= NXvHXIlkW0GQR1XS
HDLM-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET6NHZKSzVyPUm0PU4zKG6P MoGxV2FPT0WU
NB5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G2RWlEPTB;OUW2MlYhdk1? NYfabHo2W0GQR1XS
NCI-H292 NEOwdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPHeoNlUUN3ME25O|QvOzJibl2= MVHTRW5ITVJ?
A101D NHPaV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfBTWM2OD17OUCuNVkhdk1? MX;TRW5ITVJ?
NCI-H1648 M{fzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:3PIxKSzVyPUm5PE42OSCwTR?= NH\XfZpUSU6JRWK=
EKVX NV\rb4x[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPCTWM2OD1zLkCxNlkh|ryP NHzncpBUSU6JRWK=
SW1710 MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES4VYhKSzVyPUGuNFQzOzNizszN NXS1bIg3W0GQR1XS
WM-115 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfWTWM2OD1zLkC2OlU3KM7:TR?= NXqyVFBCW0GQR1XS
CAL-54 NECzfJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfzdYM1UUN3ME2xMlA4ODhzIN88US=> Ml3XV2FPT0WU
TGBC24TKB MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTnTWM2OD1zLkC4NFQ2KM7:TR?= MkjrV2FPT0WU
NCI-H520 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwMEi5Olch|ryP NUfKe4ozW0GQR1XS
D-423MG NETIeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvvR4FxUUN3ME2xMlA6QTZ{IN88US=> NIfqW2NUSU6JRWK=
BFTC-905 NH;4SIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwMUO0OFkh|ryP MXHTRW5ITVJ?
HT NXLmSlYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL3ZlZUUUN3ME2xMlE{PDd6IN88US=> NED4[lNUSU6JRWK=
CTB-1 NVrseohNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwMUSyPVMh|ryP NYqwU2drW0GQR1XS
Hs-578-T NH7oeoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{mw[mlEPTB;MT6xPVU3PSEQvF2= NFzVRYFUSU6JRWK=
HuH-7 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS0d5RKSzVyPUGuNlA6PDlizszN M1zYWXNCVkeHUh?=
LB996-RCC NUDDVph7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj2dog{UUN3ME2xMlIzOTd5IN88US=> NHLOT3dUSU6JRWK=
KYSE-270 MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LuV2lEPTB;MT6yPVc{PCEQvF2= NWS4WmFjW0GQR1XS
A4-Fuk MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofmTWM2OD1zLkK5PVk{KM7:TR?= M4j4XHNCVkeHUh?=
A498 M1TJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PSSGlEPTB;MT6zNFQ4PCEQvF2= NXXS[5lLW0GQR1XS
SK-MEL-1 NVPPXFBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\GTWM2OD1zLkOwOlc6KM7:TR?= MnnMV2FPT0WU
AU565 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXOWINVUUN3ME2xMlMyQDZ|IN88US=> NWrVO3NvW0GQR1XS
Saos-2 M1PnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37kR2lEPTB;MT6zN|IxPSEQvF2= M1v6d3NCVkeHUh?=
A549 NFPYdIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKbYhyUUN3ME2xMlM6QTdizszN MlvNV2FPT0WU
BFTC-909 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jnR2lEPTB;MT60N|MxPSEQvF2= Ml;zV2FPT0WU
MDA-MB-415 NGPLWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHlTWM2OD1zLkS4OlkzKM7:TR?= NXPnR4ZUW0GQR1XS
639-V M4LVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XpNmlEPTB;MT61NFI1PSEQvF2= M{DLSXNCVkeHUh?=
A704 NUPtRXdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe1TWM2OD1zLkWwO|g2KM7:TR?= MVLTRW5ITVJ?
PANC-03-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwNUG0NFgh|ryP MY\TRW5ITVJ?
SK-MEL-28 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLXbI1vUUN3ME2xMlU3ODh3IN88US=> MmGyV2FPT0WU
Ramos-2G6-4C10 NY[3Vm95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFwNkC3OFYh|ryP Mon2V2FPT0WU
HuP-T4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzPXlRKSzVyPUGuOlA4PzhizszN MnXoV2FPT0WU
VA-ES-BJ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\a[WlEPTB;MT62NVI4KM7:TR?= NVvXOldHW0GQR1XS
EFM-19 NU\HPY9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O2VWlEPTB;MT62NVgyKM7:TR?= M3TuUXNCVkeHUh?=
G-401 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTCTWM2OD1zLk[yNVY1KM7:TR?= NHvNVG9USU6JRWK=
D-566MG NYrHT3JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLndINKSzVyPUGuOlI2OyEQvF2= MlviV2FPT0WU
JVM-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTMTWM2OD1zLk[0PFc2KM7:TR?= NXHNR4FsW0GQR1XS
TK10 NHzubJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHPTWM2OD1zLk[3NFg{KM7:TR?= MonRV2FPT0WU
BT-20 NYLPWYx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;LWmlZUUN3ME2xMlY5QTB{IN88US=> NYPrbXpTW0GQR1XS
EGI-1 MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFwOES3NFEh|ryP NX:w[m5CW0GQR1XS
EW-16 Ml;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiycphFUUN3ME2xMlg2OTh{IN88US=> M4j6R3NCVkeHUh?=
NCI-H2228 M4TYd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG4N5dKSzVyPUGuPFUzODNizszN M2HBNHNCVkeHUh?=
BB49-HNC NHj1UoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\OVohmUUN3ME2xMlg5Pjl{IN88US=> MWrTRW5ITVJ?
G-402 NH3L[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli4TWM2OD1zLki5O|k4KM7:TR?= MYDTRW5ITVJ?
NCI-H526 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXEOXQ3UUN3ME2xMlkyOzlizszN M4H4SnNCVkeHUh?=
ME-180 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfDVGlKSzVyPUGuPVM1PzdizszN NHm2[3dUSU6JRWK=
PFSK-1 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXJTWM2OD1zLkm0OFU5KM7:TR?= MkPWV2FPT0WU
TYK-nu MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;4TWM2OD1zLkm1PFI{KM7:TR?= M{HGN3NCVkeHUh?=
HOS NIr1folIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDrTWM2OD1zLkm3PVQ5KM7:TR?= NVntb5NWW0GQR1XS
T98G M1jjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTSRmdKSzVyPUGuPVkxODZizszN M1nUXnNCVkeHUh?=
SK-MES-1 NUfI[HR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHyy[YRKSzVyPUKuNFE{OzJizszN M2Dqd3NCVkeHUh?=
SNB75 MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljwTWM2OD1{LkCxOVQyKM7:TR?= NVrye5NiW0GQR1XS
LAMA-84 MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLEWVlMUUN3ME2yMlAzPjh7IN88US=> MWrTRW5ITVJ?
CAL-39 NVvSS3ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwMEOyPEDPxE1? MonnV2FPT0WU
LOXIMVI NYPXb3RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJwMESwPFQh|ryP NES2UohUSU6JRWK=
NH-12 M2XBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfFN5dKSzVyPUKuNFU1OjRizszN NV;ue3ZrW0GQR1XS
NCI-H1048 NVu3bpZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH5TWM2OD1{LkGwOVIh|ryP MX\TRW5ITVJ?
KS-1 M1H6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe3TWM2OD1{LkGxNFAyKM7:TR?= MY\TRW5ITVJ?
NCI-N87 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHFeGpSUUN3ME2yMlE{Ozh2IN88US=> NGHMb|BUSU6JRWK=
CHP-212 NXnXcYhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTVWGN{UUN3ME2yMlE5PDR{IN88US=> Mk\DV2FPT0WU
HCC1419 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\MOXVUUUN3ME2yMlIyOTF3IN88US=> M3fjbXNCVkeHUh?=
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KINGS-1 NH[wOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPHOpYyUUN3ME24MlkzQTN6IN88US=> MnvhV2FPT0WU
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MHH-NB-11 NGHjUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PPcWlEPTB;OT6wNVg{QSEQvF2= Mn;1V2FPT0WU
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MN-60 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjKcItsUUN3ME25MlI1PTR{IN88US=> M{fRO3NCVkeHUh?=
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SN12C M{jsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\BTWM2OD17Lk[1N|M5KM7:TR?= MYjTRW5ITVJ?
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D-247MG M{XyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfRTWM2OD1zMD6wOVY5KM7:TR?= MX7TRW5ITVJ?
MPP-89 NILKclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLHTWM2OD1zMD6wPVQ3KM7:TR?= MYTTRW5ITVJ?
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NCI-H460 M4X2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TNW2lEPTB;MUCuNlgxPiEQvF2= MVLTRW5ITVJ?
NOMO-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u1WmlEPTB;MUCuN|U{OiEQvF2= NYnLR|VLW0GQR1XS
DEL NVTIfoJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF25V|VKSzVyPUGwMlM4QTRizszN MXXTRW5ITVJ?
HT55 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXoenZKSzVyPUGwMlYzODVizszN NHL2[ZpUSU6JRWK=
MC116 NFzCSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC5eoZHUUN3ME2xNE43PjV3IN88US=> MWjTRW5ITVJ?
BB30-HNC NH31RmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHWTWM2OD1zMD62Olkh|ryP M325eHNCVkeHUh?=
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U-118-MG M3exWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXETWM2OD1zMD65PFk3KM7:TR?= MWjTRW5ITVJ?
MSTO-211H MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPufFJsUUN3ME2xNU4xPzF4IN88US=> NYPTenJEW0GQR1XS
SW837 NEO2doRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFzLkC5OFkh|ryP M4Dhd3NCVkeHUh?=
HuCCT1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnwNXB3UUN3ME2xNU4yOjhzIN88US=> NV;6ZmtUW0GQR1XS
RCC10RGB NIrVeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T0c2lEPTB;MUGuNVM2KM7:TR?= M2O2PXNCVkeHUh?=
NMC-G1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXYTWM2OD1zMT6xOFk{KM7:TR?= NFTJVWFUSU6JRWK=
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HEC-1 NHPCV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFzLkSzNlgh|ryP NWLSVpJ{W0GQR1XS
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HCC1569 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fXS2lEPTB;MUGuO|Y4QCEQvF2= MWHTRW5ITVJ?
HCC1187 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGx[XprUUN3ME2xNU45PTh6IN88US=> NX;mS|ZuW0GQR1XS
EW-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFzLkm0O|Qh|ryP M4LSRnNCVkeHUh?=
LB2518-MEL NUnke3o1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvaUG9KSzVyPUGyMlA2QSEQvF2= NF3hOYtUSU6JRWK=
KALS-1 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnY[JpKSzVyPUGyMlg2PTNizszN MX7TRW5ITVJ?
8505C M33WN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF{Lki4OUDPxE1? MYPTRW5ITVJ?
SK-N-DZ MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:z[2lEPTB;MUOuNFQ2OyEQvF2= NYCyeJJOW0GQR1XS
CHP-134 M3;VNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LIPWlEPTB;MUOuNVE2QCEQvF2= Mo\IV2FPT0WU
HCE-T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjzOJJxUUN3ME2xN{4zOzZ2IN88US=> NW\PcYpPW0GQR1XS
LB-831-BLC NWTz[GhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP6TWM2OD1zMz62NlQ3KM7:TR?= NEjxPJFUSU6JRWK=
OVCAR-4 NUHKbJA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF|Lk[1NlQh|ryP Mo[wV2FPT0WU
SW756 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK5SFFZUUN3ME2xN{44OjR4IN88US=> NEDyR4hUSU6JRWK=
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SW982 NFvEOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTF|LkiyO|Yh|ryP M1PNUnNCVkeHUh?=
DB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDnTWM2OD1zMz64N|g1KM7:TR?= Mon4V2FPT0WU
H-EMC-SS NV7VZ5h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF|LkmxN|kh|ryP M3Pnb3NCVkeHUh?=
VMRC-RCZ M3KzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH33SZJKSzVyPUG0MlAxOTVizszN Ml;1V2FPT0WU
CAKI-1 NVvRcHpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLCTWM2OD1zND6wNVMzKM7:TR?= MV;TRW5ITVJ?
GI-1 M3HDN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TkVmlEPTB;MUSuNFY2QCEQvF2= M3nNcXNCVkeHUh?=
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TE-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4flc2lEPTB;MUSuO|IxQCEQvF2= M2XkfnNCVkeHUh?=
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CAL-72 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnCTWM2OD1zND63O|g{KM7:TR?= NWfiWGcyW0GQR1XS
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A2058 NGjk[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HpWmlEPTB;MUWuOVY{QCEQvF2= NV7J[GtxW0GQR1XS
PANC-08-13 M3\qTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPiXmprUUN3ME2xOU43QDV7IN88US=> MXfTRW5ITVJ?
Detroit562 MnrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESyZ41KSzVyPUG1MlkyOzlizszN MUjTRW5ITVJ?
PANC-10-05 NVX0WoV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXHTWM2OD1zNj6wPFIyKM7:TR?= M1ToOHNCVkeHUh?=
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LB771-HNC NF3XOG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXtT3lKSzVyPUG2MlQ1OjJizszN MlvnV2FPT0WU
SF268 NIi5eY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzqTWM2OD1zNj60OVIh|ryP NWnxOJVYW0GQR1XS
OE19 M2CzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy3cYxMUUN3ME2xOk42OjRizszN NXr1NYpIW0GQR1XS
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MDA-MB-231 NHf0VFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK2SYFKSzVyPUG2MlcyOzZizszN MVfTRW5ITVJ?
TGW NIe4UoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF4LkixNFIh|ryP NYiwPY55W0GQR1XS
MDA-MB-453 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF5LkCwNFMh|ryP MX\TRW5ITVJ?
SNU-C2B Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF5LkCyN|ch|ryP MmPPV2FPT0WU
A427 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fJXGlEPTB;MUeuNlM{PCEQvF2= NUfpXYMyW0GQR1XS
SK-MEL-2 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rNfGlEPTB;MUeuN|IyOyEQvF2= MVXTRW5ITVJ?
KURAMOCHI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLxOYV2UUN3ME2xO{4{QDl5IN88US=> NI\1WYZUSU6JRWK=
IST-MEL1 M2O1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nTdmlEPTB;MUeuPVE5OiEQvF2= NXzjZ4R{W0GQR1XS
NCI-H1793 M2XOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XT[mlEPTB;MUiuNVU5OSEQvF2= NIm2[ZNUSU6JRWK=
HCC1395 M{PmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\Lb2lEPTB;MUiuOVYyOSEQvF2= NYD0WVF7W0GQR1XS
NUGC-3 M37Pb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n5dWlEPTB;MUiuOlU5PCEQvF2= NYTQPG1zW0GQR1XS
BB65-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF6Lk[2PUDPxE1? MWLTRW5ITVJ?
RMG-I MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW5cYlXUUN3ME2xPE44Ozh{IN88US=> MWLTRW5ITVJ?
LS-513 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDMVYRKSzVyPUG4MlkzOjhizszN NWTTeIZWW0GQR1XS
MFM-223 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPzXlVZUUN3ME2xPU4xPzF4IN88US=> NILibo1USU6JRWK=
NCI-H727 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvZO4pKSzVyPUG5MlMzQTVizszN M3fGbnNCVkeHUh?=
KP-4 NEnocGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTF7Lki1N|Eh|ryP MUXTRW5ITVJ?
NB13 M2TGfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;6NlFKSzVyPUG5Mlg5OzlizszN NESyco5USU6JRWK=
UACC-893 NYXZVYYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF7Lkm3OVch|ryP NIDPSZpUSU6JRWK=
HT-1197 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m4RmlEPTB;MkCuNlk2QCEQvF2= M4noW3NCVkeHUh?=
NCI-H2029 M1fzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDETWM2OD1{MD6zNlY3KM7:TR?= Mly0V2FPT0WU
GI-ME-N MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzqfVJPUUN3ME2yNE4{Ozd|IN88US=> MXvTRW5ITVJ?
OVCAR-3 NGTvPXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJyLkW4NlIh|ryP NIW4TYZUSU6JRWK=
HD-MY-Z MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX1c|JEUUN3ME2yNU4{Pjl4IN88US=> MojYV2FPT0WU
NTERA-S-cl-D1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjiTWM2OD1{MT62O|IzKM7:TR?= MVXTRW5ITVJ?
SCH NEXINllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ{LkS5OkDPxE1? NWrVUFVpW0GQR1XS
KARPAS-299 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;Y[5ZIUUN3ME2yN{4{QDh5IN88US=> NUC4d4hnW0GQR1XS
NCI-H1650 NFfNbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmixTWM2OD1{Mz65NlQyKM7:TR?= MoL1V2FPT0WU
ACHN MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnkWIZKSzVyPUK0MlQ3PTZizszN M{\GOHNCVkeHUh?=
M059J NVe4VZNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\aNYRKSzVyPUK0MlU3OzRizszN MmTwV2FPT0WU
AM-38 NGLIWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3exXGlEPTB;MkWuOFgyKM7:TR?= M1\W[XNCVkeHUh?=
KG-1 NEfQfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnFXZVKSzVyPUK1MlU1QTRizszN M2rHdHNCVkeHUh?=
COLO-824 NEPWR3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnuPW5TUUN3ME2yOU42PTl7IN88US=> M3fGOHNCVkeHUh?=
NCI-H1155 NIG0TXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzeGxKSzVyPUK1MlU5PDdizszN MmTCV2FPT0WU
NCI-H441 NXK5NYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zYXmlEPTB;MkWuO|Q3PSEQvF2= M1zZfXNCVkeHUh?=
J-RT3-T3-5 NWSyOodkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LnNGlEPTB;Mk[uN|AzPyEQvF2= NUPiOVI2W0GQR1XS
JEG-3 NUPl[G1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJ4Lk[4NFUh|ryP NXnOXIl[W0GQR1XS
RKO NHnDU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJ4Lke2N|Ih|ryP MmexV2FPT0WU
CAL-85-1 NV7HPIZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrzTWM2OD1{Nz6yNVE5KM7:TR?= MXPTRW5ITVJ?
CAL-120 M1u3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XvO2lEPTB;MkeuOlkyPCEQvF2= M4ntTHNCVkeHUh?=
NCI-H2452 M4jGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm5TWM2OD1{Nz63O|E3KM7:TR?= NWHMdoxoW0GQR1XS
NCI-H1395 NHH0c2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm5dYNKSzVyPUK3Mlc5OzNizszN NU[ycWxoW0GQR1XS
KYSE-450 NI[yN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm1TWM2OD1{Nz65PFYzKM7:TR?= MV;TRW5ITVJ?
S-117 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHjWVFKSzVyPUK5MlM5PTdizszN MmLKV2FPT0WU
SW13 NVXCdFBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGNHFRUUN3ME2yPU45PTF7IN88US=> MYPTRW5ITVJ?
ES3 M1\mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfHWnR2UUN3ME2zNE4{PzN|IN88US=> MVPTRW5ITVJ?
HCT-116 M2L1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ITWM2OD1|MD61OVU1KM7:TR?= NXXmNJpWW0GQR1XS
NCI-H1693 NWi0fXVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNyLkW5OFIh|ryP MnT5V2FPT0WU
VM-CUB-1 NFrMN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;GWmlEPTB;M{CuOlQyOyEQvF2= MUPTRW5ITVJ?
NCI-H2170 M4XERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPWTllyUUN3ME2zNU42Pzh2IN88US=> MmrtV2FPT0WU
ALL-PO NUCxWXozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\nTWM2OD1|MT64OFI5KM7:TR?= MnXBV2FPT0WU
NCI-H661 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[4TWM2OD1|Mj6wOlI{KM7:TR?= M1znWXNCVkeHUh?=
NCI-H2347 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXXWoVKSzVyPUOyMlQ5OzdizszN NG\3ZmhUSU6JRWK=
FTC-133 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S3RWlEPTB;M{KuO|A3KM7:TR?= MmrGV2FPT0WU
COLO-829 NUXuS4hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT0UIdKSzVyPUOzMlM1PjdizszN NFLuTldUSU6JRWK=
GOTO NFPybXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DyeWlEPTB;M{OuOVI2QCEQvF2= NELIRppUSU6JRWK=
YAPC M3L3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\i[2lEPTB;M{OuPFE2QSEQvF2= NVrmUHE2W0GQR1XS
LCLC-103H M1TiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHNcWM3UUN3ME2zOE4yPjJ2IN88US=> NHjscGNUSU6JRWK=
SiHa MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;MXFJrUUN3ME2zOE4{QDF5IN88US=> MUnTRW5ITVJ?
LK-2 NUHhVlB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfUTWM2OD1|ND61O|A5KM7:TR?= M3;rcHNCVkeHUh?=
KP-N-YS NILTRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL3dXBKSzVyPUO0MlczODJizszN M4nHNHNCVkeHUh?=
NCI-SNU-1 M3G5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTN3LkG3PUDPxE1? NGjKUYJUSU6JRWK=
KNS-81-FD M3nudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\wWnlKSzVyPUO1MlY3OyEQvF2= MVPTRW5ITVJ?
SCC-9 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN4LkexOFYh|ryP MnX1V2FPT0WU
SH-4 NFXBcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWeyd5E2UUN3ME2zOk44OyEQvF2= NWPLWlQyW0GQR1XS
HCC-1954 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor6TWM2OD1|Nz6yO|I6KM7:TR?= NIT3cllUSU6JRWK=
BALL-1 NV;RdpF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrUTWM2OD1|Nz61N|E3KM7:TR?= MVjTRW5ITVJ?
BE-13 MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\vXWhKSzVyPUO3MlcxOThizszN MVrTRW5ITVJ?
COLO-678 NGPOdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPhcpFWUUN3ME2zO{46PDN5IN88US=> MkTjV2FPT0WU
SK-MEL-3 NGDldlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TGe2lEPTB;M{iuNlM6PyEQvF2= MnTUV2FPT0WU
OAW-28 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zq[GlEPTB;M{iuOlM6KM7:TR?= MmC2V2FPT0WU
CAMA-1 NF6xcWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK2TWM2OD1|OD65OlkyKM7:TR?= NWK2dGIzW0GQR1XS
C2BBe1 NFjzeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILId4hKSzVyPUO5MlgyQCEQvF2= M3iwOnNCVkeHUh?=
A3-KAW MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRyLkO2OlEh|ryP NYPtWZl[W0GQR1XS
SK-MEL-24 NXXvdGJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTRyLkW5N|Eh|ryP Mlq2V2FPT0WU
KYSE-140 M{S0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\vTWM2OD12MD63NVY2KM7:TR?= MVPTRW5ITVJ?
MOLT-16 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TXZWlEPTB;NEGuNVU{PiEQvF2= MX;TRW5ITVJ?
CFPAC-1 NEnPOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPwTWM2OD12Mj61NlEyKM7:TR?= M13mUnNCVkeHUh?=
NB14 NU\6PVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT6VGZKSzVyPUSyMlcxOjdizszN M4q3dHNCVkeHUh?=
COLO-792 NYXRb3ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR{Lki5OlEh|ryP M3fxU3NCVkeHUh?=
RH-1 NV;E[FRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz6TWM2OD12Mz60PFM3KM7:TR?= NV7zNoRXW0GQR1XS
NCI-H522 M3LHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDQR29uUUN3ME20OE4{PTZ6IN88US=> NFfhVItUSU6JRWK=
Ca-Ski NIDGeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT1TWM2OD12ND64NVE1KM7:TR?= MUTTRW5ITVJ?
KGN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF62dHRKSzVyPUS4MlMxPjNizszN NWC2SZdVW0GQR1XS
UACC-62 NEDFfYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXSTWM2OD12OD60NFczKM7:TR?= MUTTRW5ITVJ?
NCI-H358 NXfTVo85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrEU5N3UUN3ME20PU4{ODF6IN88US=> MW\TRW5ITVJ?
LS-411N NXfKR|NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DYV2lEPTB;NEmuN|EyQCEQvF2= MXzTRW5ITVJ?
IST-MES1 M{\4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrxfJFKSzVyPUS5MlU3OjVizszN M3nHbHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

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Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

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  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID