Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 59 Publications

9 Customer Reviews

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017, 16(4):637-648. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

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    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NVHwcmR2U2mwYYPlJGF{e2G7 M3nUWVEhcA>? M2qwZmROW09? MkXoTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP NXzDXW1LOTh5NUS2OVQ>
Sf9 MkTqT4lv[XOnIFHzd4F6 NG[xcoIyKGh? MoTnSG1UVw>? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> MmftNVg4PTR4NUS=
Sf9 NWrmNHFzU2mwYYPlJGF{e2G7 NGG2fIIyKGh? NVf1dnZ6TE2VTx?= NH7ZXGNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhTTV2NT3LJI12fGGwdDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGOxZYjwdoV{e2mwZzDwPFVidHCqYTD3bZRpKEmFNUCgc4YhOC5yMEOg{txO M{DycFE5PzV2NkW0
Sf9 NIK0XG9McW6jc3WgRZN{[Xl? MmeyNUBp MYXEUXNQ NIW2bIRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= NY\COllXOTh5NUS2OVQ>
Sf9 MmLzT4lv[XOnIFHzd4F6 NISxWHUyKGh? Mnv6SG1UVw>? M{ficmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> MVGxPFc2PDZ3NB?=
MDA-MB-361 MWrGeY5kfGmxbjDBd5NigQ>? M2Gx[FIhcA>? M3LSbWROW09? NVzn[4Z{UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO M3G3dFE5PzV2NkW0
PC3 NIKyfY9HfW6ldHnvckBCe3OjeR?= NUDBUYtXOiCq M1nO[mROW09? NGHOfmhKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? MoLFNVg4PTR4NUS=
U87MG NF:zXmxHfW6ldHnvckBCe3OjeR?= NIHu[mwzKGh? MVjEUXNQ MUfJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO NGrSZowyQDd3NE[1OC=>
MDA-MB-361 M3TqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXoPVYhcA>? NYHhcGN2TE2VTx?= NU\WdFdbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC55MjFOwG0> NXn3VpF{OTh5NUS2OVQ>
A2780 NILZbpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[5OkBp NVn1S5ZFTE2VTx?= MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IIfpeIghWEmNM1PBJIFv\CCSVFXOJI12fGG2aX;uJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? Ml22NVg4PTR4NUS=
PC3 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS0PVYhcA>? NX:wdXgyTE2VTx?= MVXJR|UxRTBwMkig{txO M2X1e|E5PzV2NkW0
U87MG M{PqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWwb2cxQTZiaB?= MonISG1UVw>? MlPvTWM2OD1yLkm1JO69VQ>? NVPMNWo{OTh5NUS2OVQ>
Sf9 NGL4VZJMcW6jc3WgRZN{[Xl? M3PYSFMxKG2rbh?= NGHrTFJFVVOR M4P0dmlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NHXZcmczOjV2OEO0Ni=>
RAW 264.7 NWfwPHE5U2mwYYPlJGF{e2G7 NFL4Wmk6OCCvaX6= NVfPRocyTE2VTx?= NVHPenVmUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5{OUig{txO NGDhUo8zOjV2OEO0Ni=>
Sf9 Mmf1T4lv[XOnIFHzd4F6 Ml;PNUBp MkHPTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN MWmyN|U1ODZ2NR?=
Sf9 NHrBRWFMcW6jc3WgRZN{[Xl? M1m5PFEhcA>? M4fZZ2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= MU[yN|U1ODZ2NR?=
Sf9 NUG3NWZOU2mwYYPlJGF{e2G7 NYXWW2RxOSCq NUHnV5N4UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> NYC2N5ByOjN3NEC2OFU>
Sf9 Mn76T4lv[XOnIFHzd4F6 MlfwNUBp NFTybFVKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk NFj5cWgzOzV2ME[0OS=>
SKOV3 M3:4XGtqdmG|ZTDBd5NigQ>? MWCxJO69VQ>? M1m0XFEhcA>? MmC5SG1UVw>? NVjsWZRTUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NVTjXIRDOjN|NkCzOFg>
MCF7 MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D2WVEh|ryP M2fNXFk3KGh? M3zIW2ROW09? MU\HTVUxRTBwMEewNkDPxE1? NVOwVnRMOjN|NkCzOFg>
SKOV3 NEnzeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PETVEh|ryP NXHyW442QTZiaB?= NHXpUW5FVVOR MmLGS2k2OD1yLkG0O|Yh|ryP NIS4UYgzOzN4MEO0PC=>
PC3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnlS2p2PzJiaB?= MUfEUXNQ NXTUNY5bUUN3ME2wMlI5KM7:TR?= NGXxS|czOTl6MUexOC=>
MCF7.1 M3zHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n0bVczKGh? NXPiVmJzTE2VTx?= MkPmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP NVWwXY01OjF7OEG3NVQ>
MCF7-neo/Her2 M1XmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[3NkBp M2PRNWROW09? M2LNdmlEPTB;MD6yPUDPxE1? MkWyNlM3PjJ7MEO=
MCF7-neo/Her2 MlqyT4lv[XOnIFHzd4F6 M4f1fmlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNid3n0bEBKSzVyIH;mJFAvODB5IN88US=> MX[yN|Y3OjlyMx?=
PC3 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;PfWhtPzJiaB?= M1q1ZmROW09? NEe5SlVGSzVyPUCuN|Qh|ryP NHHhUIMzOTl6NU[zPS=>
MCF7.1 NEXBRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPxO|IhcA>? NHzLXZpFVVOR Ml;TRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? MXmyNVk5PTZ|OR?=
PC3 NWrzWZptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Wz[VczKGh? MlvDSG1UVw>? NFT3PJhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> MkHFNlAxPTB4Nkm=
MCF7.1 M2jXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PXPVczKGh? Mn30SG1UVw>? MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO NFHlVIYzODB3ME[2PS=>
MCF7.1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGNlczKGh? MkTCSWM2OD1yLkeyJO69VQ>? NGjiRlIzODN2Nk[1Oi=>
NCI-H1975 NIjDdHFEgXSxdH;4bYMhSXO|YYm= MlzjO|IhcA>? M1z4O2lEPTB;MD6yO{DPxE1? MoG0NlMxPTl3NEW=
H460 MnLzR5l1d3SxeHnjJGF{e2G7 MWO3NkBp NV:xZmkyUUN3ME2wMlg4KM7:TR?= MUeyN|A2QTV2NR?=
HT-29 NInyZnBEgXSxdH;4bYMhSXO|YYm= M{fHNVczKGh? MUjJR|UxRTBwNk[g{txO MYCyN|A2QTV2NR?=
HepG2 MVLDfZRwfG:6aXOgRZN{[Xl? NHXt[pM4OiCq M2jaNmlEPTB;MTFOwG0> MWWyN|A2QTV2NR?=
SGC7901 Ml7NR5l1d3SxeHnjJGF{e2G7 MXy3NkBp MlfOTWM2OD1zLkig{txO MojUNlMxPTl3NEW=
NCI-H226 NGCw[45EgXSxdH;4bYMhSXO|YYm= NGHjbGg4OiCq MmnDTWM2OD1{Lkmg{txO MoTHNlMxPTl3NEW=
A549 MmD1R5l1d3SxeHnjJGF{e2G7 NFTF[I04OiCq M33LdWlEPTB;Nj65JO69VQ>? NULndlR2OjNyNUm1OFU>
U87MG M{jhT2N6fG:2b4jpZ{BCe3OjeR?= NVe1bpc5PzJiaB?= NWPZfG8xUUN3ME23Mlc4KM7:TR?= MlS1NlMxPTl3NEW=
HBC4 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzsc4dIUTVyPT22MlA{KE1? M4O0WVIzOzN4MkS2
BSY1 NGLQWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7pNYN5dG:pR1m1NF0uPi57MDDN MUWyNlM{PjJ2Nh?=
HBC5 M4OwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknRcI9oT0l3ME2tOk43OCCP MoT6NlI{OzZ{NE[=
MCF7 Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTsc4dIUTVyPT23MlM{KE1? M{PHT|IzOzN4MkS2
MDA-MB-231 NH7w[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTjS4dtd2eJSUWwQU02NjR4IF2= NXz6TnZDOjJ|M{[yOFY>
U251 NF\HOoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHCcI9oT0l3ME2tOU42OCCP NYftOGJ3OjJ|M{[yOFY>
SF268 NVvLTlNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXTPYdtd2eJSUWwQU02NjN7IF2= MYKyNlM{PjJ2Nh?=
SF295 NUDtPWJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPrdZRvdG:pR1m1NF0uPi5|NzDN M1zOXVIzOzN4MkS2
SF539 NFPxSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV21d2Q1dG:pR1m1NF0uPi53MDDN M{HQOlIzOzN4MkS2
SNB75 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLYcGN2dG:pR1m1NF0uPy5zMDDN NWPEXm1qOjJ|M{[yOFY>
SNB78 NES4VlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnBOYNtd2eJSUWwQU03NjV{IF2= MlLXNlI{OzZ{NE[=
HCC2998 NH3nVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzRU3V3dG:pR1m1NF0uPi5{OTDN NYXVUXZMOjJ|M{[yOFY>
KM12 M4[wemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHrcI9oT0l3ME2tOU44PiCP NVXvNGZvOjJ|M{[yOFY>
HT-29 NFPz[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHsc4dIUTVyPT22MlMxKE1? M4jmUVIzOzN4MkS2
HCT15 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LnV4xw\0eLNUC9MVYvOTJiTR?= MlPPNlI{OzZ{NE[=
HCT116 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorPcI9oT0l3ME2tOU45PyCP NGjtZmczOjN|NkK0Oi=>
NCI-H23 NY\mUYV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\PRYxw\0eLNUC9MVUvPzNiTR?= NYrMbHh1OjJ|M{[yOFY>
NCI-H226 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;ZOoxw\0eLNUC9MVYvOjFiTR?= NUHKSZZmOjJ|M{[yOFY>
NCI-H522 NF\mTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjI[XRGdG:pR1m1NF0uPi53ODDN MoTvNlI{OzZ{NE[=
NCI-H483 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHPd4Jtd2eJSUWwQU03NjV4IF2= MVKyNlM{PjJ2Nh?=
A549 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfQPGptd2eJSUWwQU03NjF3IF2= NXfxWZBuOjJ|M{[yOFY>
DMS273 NHLufnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrjT4RldG:pR1m1NF0uPi52MzDN NV\rNoRkOjJ|M{[yOFY>
DMS114 NX[0ZoN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLsc4dIUTVyPT21MlkzKE1? MXSyNlM{PjJ2Nh?=
LOXIMVI NUjiXYltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDsc4dIUTVyPT22MlI6KE1? NVSzdZQ4OjJ|M{[yOFY>
OVCAR3 NFLMSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHPcI9oT0l3ME2tOk44OSCP NYHFeXRvOjJ|M{[yOFY>
OVCAR4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PPeYxw\0eLNUC9MVUvPzZiTR?= MVKyNlM{PjJ2Nh?=
OVCAR5 M3nDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjsc4dIUTVyPT22MlI3KE1? NIn4cIkzOjN|NkK0Oi=>
OVCAR8 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzsc4dIUTVyPT21Mlc{KE1? MV[yNlM{PjJ2Nh?=
SKOV3 NYXJVVRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTsc4dIUTVyPT22MlUzKE1? NVrYT5RHOjJ|M{[yOFY>
RXF631L NFPx[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPsbnRtd2eJSUWwQU03Njh6IF2= NVL5W|Z[OjJ|M{[yOFY>
ACHN M2jQWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjnNG5td2eJSUWwQU03NjB5IF2= Mnf4NlI{OzZ{NE[=
St-4 MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSzcHRIdG:pR1m1NF0uPS53NjDN M3rWTlIzOzN4MkS2
MKN1 M3HTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPpTmJldG:pR1m1NF0uPy5yODDN M37mNVIzOzN4MkS2
MKN7 NVfZT3llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTjWZJtd2eJSUWwQU03NjVyIF2= M3HIPVIzOzN4MkS2
MKN28 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULsc4dIUTVyPT21MlUzKE1? NETkd4IzOjN|NkK0Oi=>
MKN45 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\IcI9oT0l3ME2tOk42PSCP MmLhNlI{OzZ{NE[=
MKN74 NXXLPGVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn1VJJtd2eJSUWwQU03NjB{IF2= NEHveVYzOjN|NkK0Oi=>
DU145 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P2TIxw\0eLNUC9MVUvQDViTR?= MXKyNlM{PjJ2Nh?=
PC3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXUflZtd2eJSUWwQU03NjZ4IF2= NE\5TYUzOjN|NkK0Oi=>
ES5 NHHPe4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\5TWM2OD13MD6yNUBvVQ>? M4[wenNCVkeHUh?=
HH MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPXTWM2OD1zMUGuNFghdk1? MnLjV2FPT0WU
MHH-PREB-1 M4Kzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDVWXBKSzVyPUGxOE4{KG6P MnixV2FPT0WU
NCI-H1770 NID6SmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7pO21KSzVyPUGyN{45PiCwTR?= Mn;QV2FPT0WU
HuO9 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj0TWM2OD1{ME[uNFIhdk1? NFLp[4xUSU6JRWK=
HAL-01 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fnXWlEPTB;MkC2Mlc{KG6P MW\TRW5ITVJ?
NOS-1 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJzMT64NkBvVQ>? Mnz2V2FPT0WU
HGC-27 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi3[JZPUUN3ME2yNVIvPTdibl2= MWrTRW5ITVJ?
NB69 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv3WlJKSzVyPUK0OU4zPyCwTR?= M{nwS3NCVkeHUh?=
RS4-11 NWH1SmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfJWGlRUUN3ME2yOlEvPzZibl2= NWLqPVUyW0GQR1XS
DOK MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnYTWM2OD1|MEGuO{BvVQ>? MYDTRW5ITVJ?
LB2241-RCC NUjNZoVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNyMz64OEBvVQ>? M4jBeXNCVkeHUh?=
NCI-H1623 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rR[GlEPTB;M{C0MlA5KG6P M{jnO3NCVkeHUh?=
YH-13 M3PkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzo[opUUUN3ME2zNFQvOzJibl2= MYDTRW5ITVJ?
BPH-1 NH3sfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTNzNDDuUS=> Mor4V2FPT0WU
AN3-CA MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPPTWM2OD1|NECuN|chdk1? MlnQV2FPT0WU
ES7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDa[2hKSzVyPUO0NU46QSCwTR?= NYjTSVljW0GQR1XS
MDA-MB-175-VII Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN3Mj65NkBvVQ>? MlW0V2FPT0WU
GAMG NHnzeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\5cYx[UUN3ME2zO|AvQDVibl2= M4j0TnNCVkeHUh?=
CHL-1 NHr5dlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfidYVFUUN3ME2zO|gvPjVibl2= MXfTRW5ITVJ?
NB7 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTN6OT64N{BvVQ>? M2[1bXNCVkeHUh?=
MFE-280 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjqWpZKSzVyPUSxPE4zKG6P MoXPV2FPT0WU
HL-60 NFXae2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpTWM2OD12MkWuO|Uhdk1? MWfTRW5ITVJ?
GCIY M1zuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[zfGlEPTB;NEOzMlghdk1? MmO3V2FPT0WU
MDA-MB-361 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj6TWM2OD12M{muNVMhdk1? M4CwenNCVkeHUh?=
LXF-289 NXzOU29KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjpTWM2OD12NEiuNlchdk1? M{DQOXNCVkeHUh?=
NBsusSR Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTR6OD64OUBvVQ>? MWTTRW5ITVJ?
KU-19-19 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;US2lEPTB;NUG2MlA4KG6P NEnXU2VUSU6JRWK=
A204 M{DXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXqeHJFUUN3ME21NlIvOzNibl2= NF\2doNUSU6JRWK=
LB1047-RCC NGnIe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW5TWM2OD13MkKuPVMhdk1? M13uVXNCVkeHUh?=
COLO-684 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKwWop2UUN3ME21NlMvOTFibl2= NHKy[ZZUSU6JRWK=
PA-1 NXixUHRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\hdXozUUN3ME21N|IvPDFibl2= MXPTRW5ITVJ?
MG-63 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rqNWlEPTB;NUSxMlEyKG6P MljiV2FPT0WU
BHT-101 M2rXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTV2ND65OEBvVQ>? NWXHcVJ2W0GQR1XS
NKM-1 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjZTWM2OD13OUOuNFkhdk1? MVHTRW5ITVJ?
T47D NXLhWopGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHxSWp2UUN3ME21PVcvPTZibl2= NIW3eJNUSU6JRWK=
MOLT-4 NIW4O4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTZ{Mz62NkBvVQ>? NVLzW5BEW0GQR1XS
IGROV-1 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW1VZI2UUN3ME22N|QvOzFibl2= MlHRV2FPT0WU
ES4 NXfVWZpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi1NmJpUUN3ME22N|kvPTRibl2= MkjSV2FPT0WU
HuO-3N1 NYDwdGlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\NTWM2OD14NEKuN|ghdk1? NVvkUZdFW0GQR1XS
NEC8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPrTmZKSzVyPU[1N{42PyCwTR?= M2PETHNCVkeHUh?=
HO-1-N-1 NYT2NGRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvpcmdKSzVyPU[1PU4yPyCwTR?= M1LRVnNCVkeHUh?=
EPCL-272H NWD5[HpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTZ6Nz6yNUBvVQ>? MmPQV2FPT0WU
D-263MG NXjWTo9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH23NWlKSzVyPUexPE4yKG6P MYrTRW5ITVJ?
MV-4-11 NIHzV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLWcXdiUUN3ME23NlQvOzFibl2= M2Hmb3NCVkeHUh?=
SK-NEP-1 NWfDNHBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni5TWM2OD15MkWuPVQhdk1? M1;3RnNCVkeHUh?=
SW872 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH4SohKSzVyPUeyO{45QSCwTR?= MYHTRW5ITVJ?
P30-OHK MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C4UGlEPTB;N{OwMlcyKG6P NIHOWIpUSU6JRWK=
OMC-1 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj4bIRKSzVyPUe1NU4xQSCwTR?= NX30cZAxW0GQR1XS
LoVo NHTRO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDvTWM2OD15N{euPUBvVQ>? MmiwV2FPT0WU
LNCaP-Clone-FGC M1P5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnFNnZKSzVyPUe5Ok4{PCCwTR?= Ml7KV2FPT0WU
L-363 NG\UUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O2c2lEPTB;N{m4MlQzKG6P M4Dtb3NCVkeHUh?=
ES8 NHezZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK5TWM2OD16MUCuOVIhdk1? M4TYOXNCVkeHUh?=
697 NUDzcVZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPETWM2OD16M{GuOVUhdk1? M4nHRXNCVkeHUh?=
HSC-3 Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nYUmlEPTB;OEO5MlU1KG6P MYfTRW5ITVJ?
H4 M4j6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\lNmlEPTB;OEWwMlg2KG6P NH\T[3RUSU6JRWK=
QIMR-WIL NWiyeoU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTyTWM2OD16NkWuNkBvVQ>? NGrQNoFUSU6JRWK=
OAW-42 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTh5Mj6xPUBvVQ>? NWG2c5ZTW0GQR1XS
MCF7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTh7OD61PUBvVQ>? NUfsXmFKW0GQR1XS
SCC-25 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTlzND6xPUBvVQ>? Ml[wV2FPT0WU
NCI-H1563 M1i1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTlzNT65PUBvVQ>? NFvhV41USU6JRWK=
OVCAR-5 NY\Yb5ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33NfWlEPTB;OUSwMlE4KG6P MWfTRW5ITVJ?
HDLM-2 NE\VfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnrbWxUUUN3ME25OFkvOiCwTR?= Mk\tV2FPT0WU
NB5 MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O0bGlEPTB;OUW2MlYhdk1? M3\Cc3NCVkeHUh?=
NCI-H292 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluwTWM2OD17N{SuN|Ihdk1? MVjTRW5ITVJ?
A101D NHf6cWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvVbYFKSzVyPUm5NE4yQSCwTR?= NYPNd4xDW0GQR1XS
NCI-H1648 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnCe2k3UUN3ME25PVgvPTFibl2= MVHTRW5ITVJ?
EKVX MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPKXYFKSzVyPUGuNFEzQSEQvF2= NEXCRpZUSU6JRWK=
SW1710 NWTBfmNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwMESyN|Mh|ryP MVLTRW5ITVJ?
WM-115 M3\hRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwME[2OVYh|ryP MVPTRW5ITVJ?
CAL-54 NFPJPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCyTWM2OD1zLkC3NFgyKM7:TR?= MlzSV2FPT0WU
TGBC24TKB MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDMWJJjUUN3ME2xMlA5ODR3IN88US=> NVjPUIY5W0GQR1XS
NCI-H520 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\KSWlEPTB;MT6wPFk3PyEQvF2= MUjTRW5ITVJ?
D-423MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHryN41KSzVyPUGuNFk6PjJizszN MlLtV2FPT0WU
BFTC-905 NYPsXVdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfVTWM2OD1zLkGzOFQ6KM7:TR?= M3PpbnNCVkeHUh?=
HT NF;XZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXRW5hXUUN3ME2xMlE{PDd6IN88US=> M3TsZnNCVkeHUh?=
CTB-1 NUDHUnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3hWVlKSzVyPUGuNVQzQTNizszN MmDzV2FPT0WU
Hs-578-T NIXabnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXkcItKSzVyPUGuNVk2PjVizszN MVfTRW5ITVJ?
HuH-7 M2DGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnXTWM2OD1zLkKwPVQ6KM7:TR?= MV7TRW5ITVJ?
LB996-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XXR2lEPTB;MT6yNlE4PyEQvF2= NVPhO49zW0GQR1XS
KYSE-270 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLYTWM2OD1zLkK5O|M1KM7:TR?= MXfTRW5ITVJ?
A4-Fuk MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPkcoNqUUN3ME2xMlI6QTl|IN88US=> MWDTRW5ITVJ?
A498 NGnhVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q2dGlEPTB;MT6zNFQ4PCEQvF2= M1TNVnNCVkeHUh?=
SK-MEL-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPaTWM2OD1zLkOwOlc6KM7:TR?= NXfNOoRVW0GQR1XS
AU565 M1:0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml30TWM2OD1zLkOxPFY{KM7:TR?= M4PpSHNCVkeHUh?=
Saos-2 NWqzbZd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD4TJJGUUN3ME2xMlM{OjB3IN88US=> NU\lfVZ6W0GQR1XS
A549 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHHXo5{UUN3ME2xMlM6QTdizszN MoDZV2FPT0WU
BFTC-909 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\DXWlEPTB;MT60N|MxPSEQvF2= M4myR3NCVkeHUh?=
MDA-MB-415 NGruOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfjXZpVUUN3ME2xMlQ5Pjl{IN88US=> M4PXenNCVkeHUh?=
639-V MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD1zLkWwNlQ2KM7:TR?= MUXTRW5ITVJ?
A704 M{TUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH2TWM2OD1zLkWwO|g2KM7:TR?= M4\aW3NCVkeHUh?=
PANC-03-27 M4TrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\4fWlEPTB;MT61NVQxQCEQvF2= M{TvWXNCVkeHUh?=
SK-MEL-28 NVqzeXczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnGeGJ{UUN3ME2xMlU3ODh3IN88US=> M2fWSXNCVkeHUh?=
Ramos-2G6-4C10 M4rLUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnzV3RWUUN3ME2xMlYxPzR4IN88US=> MVfTRW5ITVJ?
HuP-T4 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwNkC3O|gh|ryP MXrTRW5ITVJ?
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GI-ME-N MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDYWIs6UUN3ME2yNE4{Ozd|IN88US=> NH3XRXlUSU6JRWK=
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RKO MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;nR2lEPTB;Mk[uO|Y{OiEQvF2= NV:xZVhiW0GQR1XS
CAL-85-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ5LkKxNVgh|ryP NYjCd2E2W0GQR1XS
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NCI-H2452 NFj5TW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnDcYNKSzVyPUK3Mlc4OTZizszN MnPBV2FPT0WU
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KYSE-450 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\Ue2lEPTB;MkeuPVg3OiEQvF2= NF:yN2NUSU6JRWK=
S-117 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\LOXdKSzVyPUK5MlM5PTdizszN M2LaTHNCVkeHUh?=
SW13 M4rZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ7Lki1NVkh|ryP MWLTRW5ITVJ?
ES3 NFHvOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uzcmlEPTB;M{CuN|c{OyEQvF2= Ml22V2FPT0WU
HCT-116 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LBWmlEPTB;M{CuOVU2PCEQvF2= M3vENHNCVkeHUh?=
NCI-H1693 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLmTWM2OD1|MD61PVQzKM7:TR?= MUfTRW5ITVJ?
VM-CUB-1 NFP3Zo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrL[ZVKSzVyPUOwMlY1OTNizszN NVjrNIZMW0GQR1XS
NCI-H2170 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNzLkW3PFQh|ryP MmHEV2FPT0WU
ALL-PO Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjXXHJKSzVyPUOxMlg1OjhizszN NXe1SVh7W0GQR1XS
NCI-H661 MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTN{LkC2NlMh|ryP M{TnOnNCVkeHUh?=
NCI-H2347 M3LzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTN{LkS4N|ch|ryP NYXydJN3W0GQR1XS
FTC-133 NHHNVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zZNmlEPTB;M{KuO|A3KM7:TR?= M4D3dHNCVkeHUh?=
COLO-829 M2r3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN|LkO0Olch|ryP MUHTRW5ITVJ?
GOTO NET4TmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjMTWM2OD1|Mz61NlU5KM7:TR?= MXrTRW5ITVJ?
YAPC NX7RVmNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnpS5ZsUUN3ME2zN{45OTV7IN88US=> NXTufHc{W0GQR1XS
LCLC-103H NXW1UWpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K4fGlEPTB;M{SuNVYzPCEQvF2= NXrCbVBwW0GQR1XS
SiHa MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvKWVA6UUN3ME2zOE4{QDF5IN88US=> MYfTRW5ITVJ?
LK-2 NUi3eHQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[yTWM2OD1|ND61O|A5KM7:TR?= NFmyeYhUSU6JRWK=
KP-N-YS MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN2LkeyNFIh|ryP NHf3cYtUSU6JRWK=
NCI-SNU-1 MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnYT3BYUUN3ME2zOU4yPzlizszN MYnTRW5ITVJ?
KNS-81-FD NVnmVHhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rxXmlEPTB;M{WuOlY{KM7:TR?= M2K3[HNCVkeHUh?=
SCC-9 NHG4WGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\GTWM2OD1|Nj63NVQ3KM7:TR?= NEnrWpZUSU6JRWK=
SH-4 NFjCUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLxTWM2OD1|Nj63N{DPxE1? MlfBV2FPT0WU
HCC-1954 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjSTWM2OD1|Nz6yO|I6KM7:TR?= NYLTdWxpW0GQR1XS
BALL-1 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN5LkWzNVYh|ryP M3\vcnNCVkeHUh?=
BE-13 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDUZphKSzVyPUO3MlcxOThizszN NX\CZ2s5W0GQR1XS
COLO-678 NFnrOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN5Lkm0N|ch|ryP M4DkVnNCVkeHUh?=
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OAW-28 NF[4e5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN6Lk[zPUDPxE1? NX7uTGE4W0GQR1XS
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A3-KAW NHfLWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrWe4FLUUN3ME20NE4{PjZzIN88US=> NEfpVVRUSU6JRWK=
SK-MEL-24 NXn4Oo8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LSSGlEPTB;NECuOVk{OSEQvF2= M4nZWnNCVkeHUh?=
KYSE-140 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3HWm1KSzVyPUSwMlcyPjVizszN MonuV2FPT0WU
MOLT-16 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PrNGlEPTB;NEGuNVU{PiEQvF2= NXrWV5pHW0GQR1XS
CFPAC-1 NU\BRWlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf5TWM2OD12Mj61NlEyKM7:TR?= MUPTRW5ITVJ?
NB14 NVPvPJpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTR{LkewNlch|ryP NGLWXW9USU6JRWK=
COLO-792 NYLZW2NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPvcItEUUN3ME20Nk45QTZzIN88US=> MV3TRW5ITVJ?
RH-1 NVK2XHNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonoTWM2OD12Mz60PFM3KM7:TR?= MlvkV2FPT0WU
NCI-H522 M3L4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTR2LkO1Olgh|ryP NYDz[ldvW0GQR1XS
Ca-Ski MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTnSoRKSzVyPUS0MlgyOTRizszN M120VnNCVkeHUh?=
KGN NEW0UmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTR6LkOwOlMh|ryP Mn\jV2FPT0WU
UACC-62 NGi0doZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2K0d2lEPTB;NEiuOFA4OiEQvF2= NH3xR41USU6JRWK=
NCI-H358 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR7LkOwNVgh|ryP NYrUdYt{W0GQR1XS
LS-411N NHSxPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR7LkOxNVgh|ryP NUDKVVRtW0GQR1XS
IST-MES1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLnTWM2OD12OT61OlI2KM7:TR?= M{LXXHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01740336 Completed Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT00999128 Completed Healthy Volunteers Genentech Inc. October 26 2009 Phase 1
NCT01918306 Terminated Estrogen Receptor Negative Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Triple Negative Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer|Triple-negative Breast Cancer Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI)|Genentech Inc. September 2013 Phase 1|Phase 2
NCT01474668 Completed Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech Inc. October 2011 Phase 2
NCT01240226 Completed Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID