Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 76 Publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MY\LbY5ie2ViQYPzZZk> NIPXXHoyKGh? M4LKOWROW09? MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGSnbIThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? NIrQeIIyQDd3NE[1OC=>
Sf9 NX\EcmF{U2mwYYPlJGF{e2G7 MX[xJIg> M{j1ZmROW09? MVfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M4\xc|E5PzV2NkW0
Sf9 NX74fZN1U2mwYYPlJGF{e2G7 Mnj6NUBp M2OyTGROW09? Mn3oTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M1TRU|E5PzV2NkW0
Sf9 NIi4fpBMcW6jc3WgRZN{[Xl? Ml;VNUBp MkfrSG1UVw>? MWrJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMEOzJO69VQ>? M2jGOlE5PzV2NkW0
Sf9 NHvve5VMcW6jc3WgRZN{[Xl? M361XlEhcA>? NGTEW4JFVVOR NXvTS2N7UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? MXWxPFc2PDZ3NB?=
MDA-MB-361 NF;qWo9HfW6ldHnvckBCe3OjeR?= MofzNkBp MXHEUXNQ M4THdGlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvODJ6IN88US=> MlPONVg4PTR4NUS=
PC3 MmrQSpVv[3Srb36gRZN{[Xl? NF\PcVMzKGh? MnnFSG1UVw>? MofWTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> NHi1PFQyQDd3NE[1OC=>
U87MG MnHSSpVv[3Srb36gRZN{[Xl? NFXmco0zKGh? M{jnUWROW09? NEDZbJFKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP NYe2SopJOTh5NUS2OVQ>
MDA-MB-361 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HmXVk3KGh? NIjJVXhFVVOR NYjvSG1nSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC55MjFOwG0> MXuxPFc2PDZ3NB?=
A2780 M1W2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXhT3ZMQTZiaB?= NHW5UXdFVVOR NYTzPXRVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= NYrCeZJROTh5NUS2OVQ>
PC3 M{LyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi3PVYhcA>? MkDmSG1UVw>? NEPyWVFKSzVyPUCuNlgh|ryP MY[xPFc2PDZ3NB?=
U87MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzXb286PiCq NHPPNFFFVVOR M1LUeWlEPTB;MD65OUDPxE1? MlvVNVg4PTR4NUS=
Sf9 Mnf6T4lv[XOnIFHzd4F6 NH65eY4{OCCvaX6= MUnEUXNQ M1e3SGlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NG\rVFczOjV2OEO0Ni=>
RAW 264.7 M{TrU2tqdmG|ZTDBd5NigQ>? MVu5NEBucW5? MUXEUXNQ NUHjVVBvUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5{OUig{txO MYKyNlU1QDN2Mh?=
Sf9 MVXLbY5ie2ViQYPzZZk> NV3QbohrOSCq MkLYTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN NWrVXIRHOjN3NEC2OFU>
Sf9 NX3WPHp3U2mwYYPlJGF{e2G7 MmD5NUBp M3yzfGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= M1fTWFI{PTRyNkS1
Sf9 MmGyT4lv[XOnIFHzd4F6 MYOxJIg> NIHGbG5KdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\2GvbXGg[ZhxemW|c3Xk NVvZeJU6OjN3NEC2OFU>
Sf9 MY\LbY5ie2ViQYPzZZk> MkTLNUBp NWizbmVZUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2GucHjhJIV5eHKnc4Pl[C=> NGrx[ZEzOzV2ME[0OS=>
SKOV3 M3n4XWtqdmG|ZTDBd5NigQ>? M2nu[VEh|ryP MXqxJIg> NHzG[YZFVVOR MnnzTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdg>? MUSyN|M3ODN2OB?=
MCF7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r6bFEh|ryP NGnBO|k6PiCq NXvOV4lmTE2VTx?= NHLKR4xIUTVyPUCuNFcxOiEQvF2= MlrGNlM{PjB|NEi=
SKOV3 NE\5UmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\He|g{OSEQvF2= NVSxdYxSQTZiaB?= Ml7rSG1UVw>? MoC2S2k2OD1yLkG0O|Yh|ryP NHu0cmMzOzN4MEO0PC=>
PC3 NFW4RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PGWVczKGh? M3TGU2ROW09? NXnSZ|dGUUN3ME2wMlI5KM7:TR?= MUKyNVk5OTdzNB?=
MCF7.1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLGXWg4OiCq MWDEUXNQ NFTscpRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKEiHUkKg[4Vv\SC5aYToJGlEPTBib3[gNE4zQCEQvF2= NHLvNFczOTl6MUexOC=>
MCF7-neo/Her2 MmnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme5O|IhcA>? M1rpNGROW09? NUe2XHRWUUN3ME2wMlI6KM7:TR?= NVnZU2IyOjN4NkK5NFM>
MCF7-neo/Her2 NX6zNmtpU2mwYYPlJGF{e2G7 NV\XPGVkUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO Mo\rNlM3PjJ7MEO=
PC3 M3HMdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnO5O|IhcA>? NYfKXJhoTE2VTx?= MXrFR|UxRTBwM{Sg{txO NHX0cIEzOTl6NU[zPS=>
MCF7.1 NFL5RVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy4cpE4OiCq NYjwPIt[TE2VTx?= MmTuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? NV\uVlRVOjF7OEW2N|k>
PC3 NWm4SFM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jOSFczKGh? M{nKU2ROW09? MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= M{fPPVIxODVyNk[5
MCF7.1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke0O|IhcA>? MUnEUXNQ M1zYXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? MoXSNlAxPTB4Nkm=
MCF7.1 NUO1fpY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonYO|IhcA>? M3HkZWVEPTB;MD63NkDPxE1? M2fKUFIxOzR4NkW2
NCI-H1975 NVXZRpQzS3m2b4TvfIlkKEG|c3H5 M{fVVFczKGh? MVXJR|UxRTBwMkeg{txO NEnIXIkzOzB3OUW0OS=>
H460 NGq4eVJEgXSxdH;4bYMhSXO|YYm= MknWO|IhcA>? Mn;nTWM2OD1yLki3JO69VQ>? MlrhNlMxPTl3NEW=
HT-29 NIHSUXdEgXSxdH;4bYMhSXO|YYm= NWLJcFQ{PzJiaB?= NF\reXdKSzVyPUCuOlYh|ryP MUWyN|A2QTV2NR?=
HepG2 MojRR5l1d3SxeHnjJGF{e2G7 MWC3NkBp M2HKPWlEPTB;MTFOwG0> NIOwe|kzOzB3OUW0OS=>
SGC7901 NE\QelFEgXSxdH;4bYMhSXO|YYm= MVy3NkBp M3zDPWlEPTB;MT64JO69VQ>? M3nPS|I{ODV7NUS1
NCI-H226 NFTVZY9EgXSxdH;4bYMhSXO|YYm= NWHSRnA5PzJiaB?= MVPJR|UxRTJwOTFOwG0> NUXsfVBjOjNyNUm1OFU>
A549 MoDRR5l1d3SxeHnjJGF{e2G7 NVXIc4xMPzJiaB?= NHXmN5VKSzVyPU[uPUDPxE1? NET1UVgzOzB3OUW0OS=>
U87MG M2PhbmN6fG:2b4jpZ{BCe3OjeR?= M2\oeVczKGh? MU\JR|UxRTdwN{eg{txO MkXPNlMxPTl3NEW=
HBC4 NHXROZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjRZm1td2eJSUWwQU03NjB|IF2= MVWyNlM{PjJ2Nh?=
BSY1 MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF74OJRtd2eJSUWwQU03NjlyIF2= M2\WflIzOzN4MkS2
HBC5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7UcI9oT0l3ME2tOk43OCCP Mn;WNlI{OzZ{NE[=
MCF7 NWnSRYx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjsc4dIUTVyPT23MlM{KE1? NYCzXFN7OjJ|M{[yOFY>
MDA-MB-231 M3S4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnsc4dIUTVyPT21MlQ3KE1? NHfSbFYzOjN|NkK0Oi=>
U251 NGHxTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfMdmJtd2eJSUWwQU02NjVyIF2= NEDqVZQzOjN|NkK0Oi=>
SF268 M17oTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPsc4dIUTVyPT21MlM6KE1? NUX1NXhHOjJ|M{[yOFY>
SF295 M4fvcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj4eFdtd2eJSUWwQU03NjN5IF2= NIGxbGszOjN|NkK0Oi=>
SF539 NH7lcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;YSoxw\0eLNUC9MVYvPTBiTR?= NVHMR3B[OjJ|M{[yOFY>
SNB75 NH31XIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnsc4dIUTVyPT23MlExKE1? NEi2WowzOjN|NkK0Oi=>
SNB78 M{W2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm3N2ttd2eJSUWwQU03NjV{IF2= M{n5ZlIzOzN4MkS2
HCC2998 NWG5codsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK2UoZydG:pR1m1NF0uPi5{OTDN MkTiNlI{OzZ{NE[=
KM12 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPsc4dIUTVyPT21Mlc3KE1? MYKyNlM{PjJ2Nh?=
HT-29 NXnw[297T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rKSIxw\0eLNUC9MVYvOzBiTR?= MVmyNlM{PjJ2Nh?=
HCT15 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfhcI9oT0l3ME2tOk4yOiCP M1PiXlIzOzN4MkS2
HCT116 NHXtVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrHSppjdG:pR1m1NF0uPS56NzDN Mm\hNlI{OzZ{NE[=
NCI-H23 NIToeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P5c4xw\0eLNUC9MVUvPzNiTR?= MYiyNlM{PjJ2Nh?=
NCI-H226 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yy[oxw\0eLNUC9MVYvOjFiTR?= NUOxeWJuOjJ|M{[yOFY>
NCI-H522 M2fx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj2dlJtd2eJSUWwQU03NjV6IF2= MUWyNlM{PjJ2Nh?=
NCI-H483 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3uV2l7dG:pR1m1NF0uPi53NjDN MUGyNlM{PjJ2Nh?=
A549 NH:1WGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3LcI9oT0l3ME2tOk4yPSCP MnLDNlI{OzZ{NE[=
DMS273 NYTKbnFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvicI9oT0l3ME2tOk41OyCP NI\3[48zOjN|NkK0Oi=>
DMS114 M4\1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vXWIxw\0eLNUC9MVUvQTJiTR?= MnLMNlI{OzZ{NE[=
LOXIMVI MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnOb2Jtd2eJSUWwQU03NjJ7IF2= NWTFS4pxOjJ|M{[yOFY>
OVCAR3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HDWIxw\0eLNUC9MVYvPzFiTR?= NFvpTmczOjN|NkK0Oi=>
OVCAR4 M2nkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rs[Yxw\0eLNUC9MVUvPzZiTR?= NGD2R3UzOjN|NkK0Oi=>
OVCAR5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjuU4Ntd2eJSUWwQU03NjJ4IF2= MW[yNlM{PjJ2Nh?=
OVCAR8 NGPjRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXJcI9oT0l3ME2tOU44OyCP NVzCdGlQOjJ|M{[yOFY>
SKOV3 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjze41ldG:pR1m1NF0uPi53MjDN MYGyNlM{PjJ2Nh?=
RXF631L MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHsc4dIUTVyPT22Mlg5KE1? Mk[wNlI{OzZ{NE[=
ACHN MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDmNGNtd2eJSUWwQU03NjB5IF2= MVGyNlM{PjJ2Nh?=
St-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq4cI9oT0l3ME2tOU42PiCP M4i2PVIzOzN4MkS2
MKN1 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHiTYsxdG:pR1m1NF0uPy5yODDN NEjWZ|MzOjN|NkK0Oi=>
MKN7 NGH6ZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLsc4dIUTVyPT22MlUxKE1? NGrwToIzOjN|NkK0Oi=>
MKN28 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT0SYc1dG:pR1m1NF0uPS53MjDN MYmyNlM{PjJ2Nh?=
MKN45 NYfaUFFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TiWIxw\0eLNUC9MVYvPTViTR?= MVKyNlM{PjJ2Nh?=
MKN74 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLPRndtd2eJSUWwQU03NjB{IF2= M1jnSlIzOzN4MkS2
DU145 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDVNWJHdG:pR1m1NF0uPS56NTDN NV\5[VJ[OjJ|M{[yOFY>
PC3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjs[XRRdG:pR1m1NF0uPi54NjDN NVT3V|FpOjJ|M{[yOFY>
ES5 M3;jTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3UXFHUUN3ME21NE4zOSCwTR?= NF76R5NUSU6JRWK=
HH NHG4dWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFzMT6wPEBvVQ>? NICz[HVUSU6JRWK=
MHH-PREB-1 M2fYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF75S5NKSzVyPUGxOE4{KG6P M2riTXNCVkeHUh?=
NCI-H1770 M1;3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzlU5JKSzVyPUGyN{45PiCwTR?= Ml7ZV2FPT0WU
HuO9 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfKOotnUUN3ME2yNFYvODJibl2= M1\hb3NCVkeHUh?=
HAL-01 NXqyfFd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJyNj63N{BvVQ>? MXjTRW5ITVJ?
NOS-1 M3PERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJzMT64NkBvVQ>? NFjab5RUSU6JRWK=
HGC-27 NH:3TIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJzMj61O{BvVQ>? MVfTRW5ITVJ?
NB69 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDFTWM2OD1{NEWuNlchdk1? Ml7HV2FPT0WU
RS4-11 M33ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ4MT63OkBvVQ>? MlTXV2FPT0WU
DOK M3HET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNyMT63JI5O M1PjeHNCVkeHUh?=
LB2241-RCC NYnBO5ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTNyMz64OEBvVQ>? MVHTRW5ITVJ?
NCI-H1623 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPp[G1KSzVyPUOwOE4xQCCwTR?= M1;IdXNCVkeHUh?=
YH-13 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL0V4dKSzVyPUOwOE4{OiCwTR?= MV\TRW5ITVJ?
BPH-1 NXTEW4pPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfVU|Y3UUN3ME2zNVQhdk1? M{DxVHNCVkeHUh?=
AN3-CA MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj1XXRKSzVyPUO0NE4{PyCwTR?= M3HWOXNCVkeHUh?=
ES7 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN2MT65PUBvVQ>? MYnTRW5ITVJ?
MDA-MB-175-VII M4nxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPnTWM2OD1|NUKuPVIhdk1? NXLoTlRNW0GQR1XS
GAMG MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfQWoRKSzVyPUO3NE45PSCwTR?= MlrLV2FPT0WU
CHL-1 NGTibpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj0RmRKSzVyPUO3PE43PSCwTR?= MXvTRW5ITVJ?
NB7 M2fDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvYWlVKSzVyPUO4PU45OyCwTR?= NV;TXYRuW0GQR1XS
MFE-280 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6e4ZKSzVyPUSxPE4zKG6P MnXyV2FPT0WU
HL-60 NXPtb3pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O5UmlEPTB;NEK1Mlc2KG6P MlzGV2FPT0WU
GCIY NWTVUnFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3TfI5XUUN3ME20N|MvQCCwTR?= MV;TRW5ITVJ?
MDA-MB-361 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLSTWM2OD12M{muNVMhdk1? M{PmfXNCVkeHUh?=
LXF-289 MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\jU2lEPTB;NES4MlI4KG6P MnX3V2FPT0WU
NBsusSR NX\oOY1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nKNWlEPTB;NEi4Mlg2KG6P M4WyN3NCVkeHUh?=
KU-19-19 NWDkVmR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWTWM2OD13MU[uNFchdk1? Mo\WV2FPT0WU
A204 M1;vN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX4e3VKSzVyPUWyNk4{OyCwTR?= MX;TRW5ITVJ?
LB1047-RCC NYK2Uo9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTV{Mj65N{BvVQ>? M{fBU3NCVkeHUh?=
COLO-684 M{fzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPkXoxKSzVyPUWyN{4yOSCwTR?= MXPTRW5ITVJ?
PA-1 NWDBbI56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\ibGhMUUN3ME21N|IvPDFibl2= Mo\pV2FPT0WU
MG-63 NYrWVGtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD13NEGuNVEhdk1? NXTafndUW0GQR1XS
BHT-101 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTV2ND65OEBvVQ>? M4HsW3NCVkeHUh?=
NKM-1 NVfscWhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGraWW9KSzVyPUW5N{4xQSCwTR?= NUTZc2hGW0GQR1XS
T47D Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTV7Nz61OkBvVQ>? Mlz4V2FPT0WU
MOLT-4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml35TWM2OD14MkOuOlIhdk1? NG\XN5pUSU6JRWK=
IGROV-1 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom1TWM2OD14M{SuN|Ehdk1? MnfLV2FPT0WU
ES4 M{PtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTZ|OT61OEBvVQ>? MnvSV2FPT0WU
HuO-3N1 NVvmc5VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX5PIVKSzVyPU[0Nk4{QCCwTR?= NHTxS29USU6JRWK=
NEC8 NHThRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml36TWM2OD14NUOuOVchdk1? MmPRV2FPT0WU
HO-1-N-1 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTZ3OT6xO{BvVQ>? NWTCfItYW0GQR1XS
EPCL-272H M{\DUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXPZ5hKSzVyPU[4O{4zOSCwTR?= M3LJb3NCVkeHUh?=
D-263MG NIXSUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTdzOD6xJI5O NFW5[I9USU6JRWK=
MV-4-11 M{\pZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPqTWM2OD15MkSuN|Ehdk1? NEW4WWdUSU6JRWK=
SK-NEP-1 NUC1e3FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTITWM2OD15MkWuPVQhdk1? Mk\TV2FPT0WU
SW872 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTd{Nz64PUBvVQ>? NVfkZXJtW0GQR1XS
P30-OHK NV7qW|VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETWfYNKSzVyPUezNE44OSCwTR?= NXfnTFhoW0GQR1XS
OMC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\BNGlEPTB;N{WxMlA6KG6P NEnzPWlUSU6JRWK=
LoVo MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTd5Nz65JI5O MnfqV2FPT0WU
LNCaP-Clone-FGC NIPKcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPGbotYUUN3ME23PVYvOzRibl2= NWG4XFRZW0GQR1XS
L-363 M3vwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTd7OD60NkBvVQ>? M2LMbnNCVkeHUh?=
ES8 M4XWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH6WYRKSzVyPUixNE42OiCwTR?= NI\aW2pUSU6JRWK=
697 M4PqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W5PWlEPTB;OEOxMlU2KG6P NV7yRXc4W0GQR1XS
HSC-3 M4rkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTh|OT61OEBvVQ>? NGTXd2JUSU6JRWK=
H4 M4GyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPuVJBNUUN3ME24OVAvQDVibl2= M2LKSnNCVkeHUh?=
QIMR-WIL M4LZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7zTWM2OD16NkWuNkBvVQ>? MVHTRW5ITVJ?
OAW-42 NHXQfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTh5Mj6xPUBvVQ>? MWPTRW5ITVJ?
MCF7 M37PdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPaTmxKSzVyPUi5PE42QSCwTR?= NUD6WW9OW0GQR1XS
SCC-25 NGfOTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTlzND6xPUBvVQ>? MWjTRW5ITVJ?
NCI-H1563 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHLTWM2OD17MUWuPVkhdk1? M3X3fXNCVkeHUh?=
OVCAR-5 NVe1TGhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHERVhKSzVyPUm0NE4yPyCwTR?= NIHsfYhUSU6JRWK=
HDLM-2 NUTFR29HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jydGlEPTB;OUS5MlIhdk1? MXPTRW5ITVJ?
NB5 NGHPem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTl3Nj62JI5O M2DwR3NCVkeHUh?=
NCI-H292 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLrTWM2OD17N{SuN|Ihdk1? NITHfXRUSU6JRWK=
A101D M1izVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[ybXU{UUN3ME25PVAvOTlibl2= MUXTRW5ITVJ?
NCI-H1648 MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPjdYNtUUN3ME25PVgvPTFibl2= MoPQV2FPT0WU
EKVX NXLPSmhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\OcIY{UUN3ME2xMlAyOjlizszN MnW2V2FPT0WU
SW1710 NYHNVmdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjNeGNKSzVyPUGuNFQzOzNizszN NEPIbnhUSU6JRWK=
WM-115 NWX6O2pwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXGTWM2OD1zLkC2OlU3KM7:TR?= NUHFT5JTW0GQR1XS
CAL-54 M3XWUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF73b45KSzVyPUGuNFcxQDFizszN MYfTRW5ITVJ?
TGBC24TKB M{jOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwMEiwOFUh|ryP MnSwV2FPT0WU
NCI-H520 NYnzV2NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVew[FVjUUN3ME2xMlA5QTZ5IN88US=> M{DWenNCVkeHUh?=
D-423MG NV\EeZR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HPNGlEPTB;MT6wPVk3OiEQvF2= NXvGOFNCW0GQR1XS
BFTC-905 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwMUO0OFkh|ryP M4P6XHNCVkeHUh?=
HT MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwMUO0O|gh|ryP M3ewO3NCVkeHUh?=
CTB-1 M{fURmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwMUSyPVMh|ryP M4HiS3NCVkeHUh?=
Hs-578-T MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nXbGlEPTB;MT6xPVU3PSEQvF2= NF;TWpFUSU6JRWK=
HuH-7 NVPTZVk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PKWmlEPTB;MT6yNFk1QSEQvF2= MofHV2FPT0WU
LB996-RCC NUPrZ3d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDjPHdKSzVyPUGuNlIyPzdizszN MlX0V2FPT0WU
KYSE-270 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPzSYpKSzVyPUGuNlk4OzRizszN NVfKSYszW0GQR1XS
A4-Fuk M1LnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLZTXdNUUN3ME2xMlI6QTl|IN88US=> MXTTRW5ITVJ?
A498 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfQTWM2OD1zLkOwOFc1KM7:TR?= M1jXXnNCVkeHUh?=
SK-MEL-1 MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPISHlKSzVyPUGuN|A3PzlizszN NVrhR5lOW0GQR1XS
AU565 M3HNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\rUoFKSzVyPUGuN|E5PjNizszN MoLkV2FPT0WU
Saos-2 M{DhR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfqTWM2OD1zLkOzNlA2KM7:TR?= NUfHUlBRW0GQR1XS
A549 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwM{m5O{DPxE1? NXuzN4dGW0GQR1XS
BFTC-909 NFfDSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XGXmlEPTB;MT60N|MxPSEQvF2= NWLlOWJKW0GQR1XS
MDA-MB-415 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7mO4JKSzVyPUGuOFg3QTJizszN M{LpSXNCVkeHUh?=
639-V NETBbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\LS2lEPTB;MT61NFI1PSEQvF2= M4T1ZXNCVkeHUh?=
A704 MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPzTWM2OD1zLkWwO|g2KM7:TR?= NUHUcoFbW0GQR1XS
PANC-03-27 M3HDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P5emlEPTB;MT61NVQxQCEQvF2= NULrSXBTW0GQR1XS
SK-MEL-28 NH;kS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonJTWM2OD1zLkW2NFg2KM7:TR?= MUTTRW5ITVJ?
Ramos-2G6-4C10 NIDQcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKzTWM2OD1zLk[wO|Q3KM7:TR?= M2e5ZnNCVkeHUh?=
HuP-T4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCR2lEPTB;MT62NFc4QCEQvF2= NXrPclBGW0GQR1XS
VA-ES-BJ M1HnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyy[5JPUUN3ME2xMlYyOjdizszN MkO4V2FPT0WU
EFM-19 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\pfFhKSzVyPUGuOlE5OSEQvF2= MWfTRW5ITVJ?
G-401 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPaU|lYUUN3ME2xMlYzOTZ2IN88US=> MnPtV2FPT0WU
D-566MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHjTWM2OD1zLk[yOVMh|ryP MXvTRW5ITVJ?
JVM-3 NXHKdIN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwNkS4O|Uh|ryP MX\TRW5ITVJ?
TK10 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofCTWM2OD1zLk[3NFg{KM7:TR?= Ml;qV2FPT0WU
BT-20 NXzaPFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\zR4hKSzVyPUGuOlg6ODJizszN NEm4VpNUSU6JRWK=
EGI-1 NEjsS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknXTWM2OD1zLki0O|AyKM7:TR?= NY\zbohTW0GQR1XS
EW-16 NGXWR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnsXmxkUUN3ME2xMlg2OTh{IN88US=> MXPTRW5ITVJ?
NCI-H2228 NVfpfIpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwOEWyNFMh|ryP NW\GSGR4W0GQR1XS
BB49-HNC NYK4cnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;DTWM2OD1zLki4OlkzKM7:TR?= NGj4NWRUSU6JRWK=
G-402 M2[xOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTpNoMzUUN3ME2xMlg6Pzl5IN88US=> NUj0dGtNW0GQR1XS
NCI-H526 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV33ZY1kUUN3ME2xMlkyOzlizszN NWCzR4JRW0GQR1XS
ME-180 NHrIWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHwTWM2OD1zLkmzOFc4KM7:TR?= MlTYV2FPT0WU
PFSK-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\aO2lEPTB;MT65OFQ2QCEQvF2= M1Hj[XNCVkeHUh?=
TYK-nu MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwOUW4NlMh|ryP MWHTRW5ITVJ?
HOS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLidGJ[UUN3ME2xMlk4QTR6IN88US=> Mn3hV2FPT0WU
T98G NHzlWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFwOUmwNFYh|ryP NEDXNHVUSU6JRWK=
SK-MES-1 NF7ze|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjFdpd[UUN3ME2yMlAyOzN{IN88US=> NH;RV3ZUSU6JRWK=
SNB75 NIPSNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjvTWM2OD1{LkCxOVQyKM7:TR?= MV7TRW5ITVJ?
LAMA-84 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnXTWM2OD1{LkCyOlg6KM7:TR?= MVzTRW5ITVJ?
CAL-39 NGHufHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnETWM2OD1{LkCzNlgh|ryP NE\FcWtUSU6JRWK=
LOXIMVI M{nCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LOcmlEPTB;Mj6wOFA5PCEQvF2= M{HXOXNCVkeHUh?=
NH-12 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJwMEW0NlQh|ryP NIDKfIVUSU6JRWK=
NCI-H1048 M4jXeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJwMUC1NkDPxE1? NF;zdnlUSU6JRWK=
KS-1 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTEfpFkUUN3ME2yMlEyODBzIN88US=> M2n3fXNCVkeHUh?=
NCI-N87 NVPmfnlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPTOIZKSzVyPUKuNVM{QDRizszN NGrvVWNUSU6JRWK=
CHP-212 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrSTFRKSzVyPUKuNVg1PDJizszN MYjTRW5ITVJ?
HCC1419 NFTPb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjUOmlKSzVyPUKuNlEyOTVizszN NHThOIlUSU6JRWK=
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NCI-H2030 NWrlUYdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnqNYpvUUN3ME2yMlI1OTJ|IN88US=> M{\lbXNCVkeHUh?=
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Detroit562 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfZTWM2OD1zNT65NVM6KM7:TR?= MV7TRW5ITVJ?
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M059J NFXHRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPaTWM2OD1{ND61OlM1KM7:TR?= NWrCeZdlW0GQR1XS
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KG-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX5TWM2OD1{NT61OFk1KM7:TR?= Ml;KV2FPT0WU
COLO-824 NVzPeoJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ERYlKSzVyPUK1MlU2QTlizszN NH\1WW9USU6JRWK=
NCI-H1155 NHjTPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ3LkW4OFch|ryP NYX0[FR4W0GQR1XS
NCI-H441 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfyTWM2OD1{NT63OFY2KM7:TR?= MWPTRW5ITVJ?
J-RT3-T3-5 M{GycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj1dY5KSzVyPUK2MlMxOjdizszN Mn7qV2FPT0WU
JEG-3 M3rEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqxUVdTUUN3ME2yOk43QDB3IN88US=> MWnTRW5ITVJ?
RKO NGTWcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnGeYJoUUN3ME2yOk44PjN{IN88US=> NWHvXnJrW0GQR1XS
CAL-85-1 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD6TWM2OD1{Nz6yNVE5KM7:TR?= M{LxUHNCVkeHUh?=
CAL-120 NGq5Xo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDHRW5KSzVyPUK3MlY6OTRizszN NIrteZZUSU6JRWK=
NCI-H2452 NWTmbFNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnSTWM2OD1{Nz63O|E3KM7:TR?= MoXQV2FPT0WU
NCI-H1395 NFrWRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnjUYxNUUN3ME2yO{44QDN|IN88US=> MXvTRW5ITVJ?
KYSE-450 MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXmTWM2OD1{Nz65PFYzKM7:TR?= M2nQRXNCVkeHUh?=
S-117 NX7abowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ7LkO4OVch|ryP MXfTRW5ITVJ?
SW13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HlfmlEPTB;MkmuPFUyQSEQvF2= NETTR4dUSU6JRWK=
ES3 MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjQTWM2OD1|MD6zO|M{KM7:TR?= Ml7VV2FPT0WU
HCT-116 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT5bW04UUN3ME2zNE42PTV2IN88US=> MVXTRW5ITVJ?
NCI-H1693 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDlfZpTUUN3ME2zNE42QTR{IN88US=> NH7ENHBUSU6JRWK=
VM-CUB-1 M4fBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXlTWM2OD1|MD62OFE{KM7:TR?= NGHoS3VUSU6JRWK=
NCI-H2170 M3;LXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vsPWlEPTB;M{GuOVc5PCEQvF2= NXvufIJqW0GQR1XS
ALL-PO NX;SZVVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zpfWlEPTB;M{GuPFQzQCEQvF2= NYHxXWJ7W0GQR1XS
NCI-H661 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTN{LkC2NlMh|ryP NVyyXYxRW0GQR1XS
NCI-H2347 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTCcmpKSzVyPUOyMlQ5OzdizszN MlnQV2FPT0WU
FTC-133 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KTWM2OD1|Mj63NFYh|ryP NFq2dGhUSU6JRWK=
COLO-829 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nubGlEPTB;M{OuN|Q3PyEQvF2= NWnnWZJuW0GQR1XS
GOTO NFzVbXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{WxfGlEPTB;M{OuOVI2QCEQvF2= NWLl[oFuW0GQR1XS
YAPC NHL0OpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\XTWM2OD1|Mz64NVU6KM7:TR?= NVLYdINIW0GQR1XS
LCLC-103H NY\RSWp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj1OHFKSzVyPUO0MlE3OjRizszN M4TPbXNCVkeHUh?=
SiHa Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TUcmlEPTB;M{SuN|gyPyEQvF2= M1O5R3NCVkeHUh?=
LK-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj1TWM2OD1|ND61O|A5KM7:TR?= NWnQTpdbW0GQR1XS
KP-N-YS M{K4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj4TWM2OD1|ND63NlAzKM7:TR?= NF;jO|NUSU6JRWK=
NCI-SNU-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7uXVZCUUN3ME2zOU4yPzlizszN NXLiflZiW0GQR1XS
KNS-81-FD MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN3Lk[2N{DPxE1? MUXTRW5ITVJ?
SCC-9 NYrBNJl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHtOIhtUUN3ME2zOk44OTR4IN88US=> MlTFV2FPT0WU
SH-4 M324b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN4LkezJO69VQ>? MUPTRW5ITVJ?
HCC-1954 NFLaNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XXcGlEPTB;M{euNlczQSEQvF2= NXnJVoN4W0GQR1XS
BALL-1 M4GxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXhNHRQUUN3ME2zO{42OzF4IN88US=> M{jMTnNCVkeHUh?=
BE-13 M4XaSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnYO2NKSzVyPUO3MlcxOThizszN NHvPSGRUSU6JRWK=
COLO-678 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzhVlJjUUN3ME2zO{46PDN5IN88US=> MW\TRW5ITVJ?
SK-MEL-3 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHITWM2OD1|OD6yN|k4KM7:TR?= MYXTRW5ITVJ?
OAW-28 M4fIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkewTWM2OD1|OD62N|kh|ryP M4X2WnNCVkeHUh?=
CAMA-1 NVvINWVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN6Lkm2PVEh|ryP MUXTRW5ITVJ?
C2BBe1 NI\kbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInHNoFKSzVyPUO5MlgyQCEQvF2= MUjTRW5ITVJ?
A3-KAW NX7X[4d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXmeZRyUUN3ME20NE4{PjZzIN88US=> M1PoVnNCVkeHUh?=
SK-MEL-24 NGXpUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRyLkW5N|Eh|ryP NHvDOWdUSU6JRWK=
KYSE-140 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PHOWlEPTB;NECuO|E3PSEQvF2= NEnkNoNUSU6JRWK=
MOLT-16 NV:xbFFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2CzVmlEPTB;NEGuNVU{PiEQvF2= NFi3SW9USU6JRWK=
CFPAC-1 MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTR{LkWyNVEh|ryP NHfoXZRUSU6JRWK=
NB14 NFWzdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIruUVhKSzVyPUSyMlcxOjdizszN NWLaNFBDW0GQR1XS
COLO-792 NUD4WIw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPwTWM2OD12Mj64PVYyKM7:TR?= NWfPZmdJW0GQR1XS
RH-1 NF[3OmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTJN5d1UUN3ME20N{41QDN4IN88US=> MnrwV2FPT0WU
NCI-H522 Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWyTWM2OD12ND6zOVY5KM7:TR?= NHfMUlBUSU6JRWK=
Ca-Ski M3XiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknKTWM2OD12ND64NVE1KM7:TR?= NEnSfW5USU6JRWK=
KGN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTR6LkOwOlMh|ryP NYrWZ|IyW0GQR1XS
UACC-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXpTWM2OD12OD60NFczKM7:TR?= NYfZSVlCW0GQR1XS
NCI-H358 NFjOR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\sUXhKSzVyPUS5MlMxOThizszN NHXofmtUSU6JRWK=
LS-411N M4qzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR7LkOxNVgh|ryP Ml\wV2FPT0WU
IST-MES1 NHnmdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjTO|Y5UUN3ME20PU42PjJ3IN88US=> M2fGNXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01740336 Completed Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID