Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 114 Publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NHq5emJMcW6jc3WgRZN{[Xl? NYn1[WhvOSCq NH7INoxFVVOR NWrxN|cxUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NYnZTHZQOTh5NUS2OVQ>
Sf9 M2jnemtqdmG|ZTDBd5NigQ>? NYXrZ3NFOSCq NHT3WZhFVVOR MoOxTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGgyODR5LWKgcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> MW[xPFc2PDZ3NB?=
Sf9 NITJdJdMcW6jc3WgRZN{[Xl? NVyzTXFROSCq MVfEUXNQ MnziTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M4HTSVE5PzV2NkW0
Sf9 MWTLbY5ie2ViQYPzZZk> NHTYZlMyKGh? MVPEUXNQ MVnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMEOzJO69VQ>? NYrMO3cxOTh5NUS2OVQ>
Sf9 M1;0cWtqdmG|ZTDBd5NigQ>? NETtZo8yKGh? MnLzSG1UVw>? MnrmTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCjbIDoZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZS=> MkDZNVg4PTR4NUS=
MDA-MB-361 NFjtSppHfW6ldHnvckBCe3OjeR?= MWGyJIg> NFHjUIpFVVOR MXzJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NX7EPZBYOTh5NUS2OVQ>
PC3 NYDlT4ZZTnWwY4Tpc44hSXO|YYm= M4DRdVIhcA>? MXvEUXNQ M3j1VWlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGDDN{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yM{eg{txO MVyxPFc2PDZ3NB?=
U87MG NHq5Vo5HfW6ldHnvckBCe3OjeR?= MUmyJIg> NHT1d3BFVVOR NGLuWJZKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP MX2xPFc2PDZ3NB?=
MDA-MB-361 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvFPVYhcA>? NVvuS4p2TE2VTx?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= NEPLbJMyQDd3NE[1OC=>
A2780 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXTW2pmQTZiaB?= NETxWJBFVVOR NXTXUms6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= MXixPFc2PDZ3NB?=
PC3 NGfwPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjiO3A6PiCq NFnMV|dFVVOR MXTJR|UxRTBwMkig{txO MU[xPFc2PDZ3NB?=
U87MG NEn4fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLnPVYhcA>? NWnjcW1qTE2VTx?= MYjJR|UxRTBwOUWg{txO M3rGb|E5PzV2NkW0
Sf9 NH7Xc2FMcW6jc3WgRZN{[Xl? MkjoN|AhdWmw M4X1ZmROW09? MnHSTY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHHtc5VvfCCxZjDBWHAh[2:wc4Xt[YQhf2m2aDDJR|UxKG:oIECuNFQzKM7:TR?= MX2yNlU1QDN2Mh?=
RAW 264.7 NGi2SmdMcW6jc3WgRZN{[Xl? NELGNJo6OCCvaX6= MY\EUXNQ NGjqVYhKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> MVWyNlU1QDN2Mh?=
Sf9 NH\3cmZMcW6jc3WgRZN{[Xl? NXfaSY1ZOSCq NFjUU5FKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NXHy[XE4OjN3NEC2OFU>
Sf9 NInWdpZMcW6jc3WgRZN{[Xl? MVWxJIg> MW\Jcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm NGjXVpEzOzV2ME[0OS=>
Sf9 NVXiO44zU2mwYYPlJGF{e2G7 MkLjNUBp M4rXcWlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= MYiyN|U1ODZ2NR?=
Sf9 NEHWfolMcW6jc3WgRZN{[Xl? NV;lRpVuOSCq NGT6T5BKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk NH7WcJMzOzV2ME[0OS=>
SKOV3 MV7LbY5ie2ViQYPzZZk> M33xZVEh|ryP NEfzRnQyKGh? M1f1OGROW09? M{n6WmlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25? M1TZbVI{OzZyM{S4
MCF7 NIPsc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYGxJO69VQ>? MXe5OkBp MkHxSG1UVw>? NH\wUFFIUTVyPUCuNFcxOiEQvF2= M1q3fVI{OzZyM{S4
SKOV3 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPJPJhEOSEQvF2= M2[zVFk3KGh? M4HqfWROW09? NWHTN|I2T0l3ME2wMlE1PzZizszN NIfiS4gzOzN4MEO0PC=>
PC3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XGXFczKGh? NEHTXXRFVVOR NFvJU5RKSzVyPUCuNlgh|ryP NWDtPHZkOjF7OEG3NVQ>
MCF7.1 NX;1UFNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPjO|IhcA>? NH3oWWlFVVOR NYHpSpc3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN NF;NXHkzOTl6MUexOC=>
MCF7-neo/Her2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37hbVczKGh? M3nwcGROW09? NVm0e4lFUUN3ME2wMlI6KM7:TR?= NF;BfmIzOzZ4MkmwNy=>
MCF7-neo/Her2 NHiwdFRMcW6jc3WgRZN{[Xl? NELzO3FKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjDheEBUPDd|IIfpeIghUUN3MDDv[kAxNjByNzFOwG0> MmL5NlM3PjJ7MEO=
PC3 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP0O|IhcA>? NEPXd4pFVVOR Mk\4SWM2OD1yLkO0JO69VQ>? NGfjRYMzOTl6NU[zPS=>
MCF7.1 NIXWNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKzeGQ4OiCq NFTRcnBFVVOR M3foOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFXDOVAhd2ZiMD6zPUDPxE1? M4S2blIyQTh3NkO5
PC3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUO3NkBp NYHKTJp[TE2VTx?= NEHZWZJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> MVOyNFA2ODZ4OR?=
MCF7.1 NGPNXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\UO|IhcA>? M4HvOmROW09? NFzJR2xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDJR|UxKG:oIECuN|Qh|ryP NEe5RpEzODB3ME[2PS=>
MCF7.1 NIjFc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS3NkBp M4PCUWVEPTB;MD63NkDPxE1? NEHmWmgzODN2Nk[1Oi=>
NCI-H1975 NUDNbpdvS3m2b4TvfIlkKEG|c3H5 Mn;wO|IhcA>? NVfYNFZMUUN3ME2wMlI4KM7:TR?= M2Phc|I{ODV7NUS1
H460 NVTpR2JHS3m2b4TvfIlkKEG|c3H5 MnzJO|IhcA>? MXTJR|UxRTBwOEeg{txO MXSyN|A2QTV2NR?=
HT-29 NVvUR2t[S3m2b4TvfIlkKEG|c3H5 NUXEfoFRPzJiaB?= NUi1Xog5UUN3ME2wMlY3KM7:TR?= MUGyN|A2QTV2NR?=
HepG2 MVTDfZRwfG:6aXOgRZN{[Xl? NF20[YU4OiCq MWrJR|UxRTFizszN NWjvUFBOOjNyNUm1OFU>
SGC7901 MXTDfZRwfG:6aXOgRZN{[Xl? NVjpXndtPzJiaB?= MkXlTWM2OD1zLkig{txO NVmwPINwOjNyNUm1OFU>
NCI-H226 NEH5OGhEgXSxdH;4bYMhSXO|YYm= NXziSZRtPzJiaB?= M4D6[2lEPTB;Mj65JO69VQ>? MmXTNlMxPTl3NEW=
A549 MYjDfZRwfG:6aXOgRZN{[Xl? NF\I[lI4OiCq Mn7CTWM2OD14Lkmg{txO MVSyN|A2QTV2NR?=
U87MG NE\pUItEgXSxdH;4bYMhSXO|YYm= MYG3NkBp NW\5NHl1UUN3ME23Mlc4KM7:TR?= NGPWbIkzOzB3OUW0OS=>
HBC4 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3Be4xLdG:pR1m1NF0uPi5yMzDN MkW5NlI{OzZ{NE[=
BSY1 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX20flVzdG:pR1m1NF0uPi57MDDN NIPRZ2MzOjN|NkK0Oi=>
HBC5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPsc4dIUTVyPT22MlYxKE1? NXzuZpl6OjJ|M{[yOFY>
MCF7 M4\Rb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkS5cI9oT0l3ME2tO{4{OyCP MXOyNlM{PjJ2Nh?=
MDA-MB-231 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDsc4dIUTVyPT21MlQ3KE1? MkP5NlI{OzZ{NE[=
U251 M3vHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;wfIxw\0eLNUC9MVUvPTBiTR?= MV2yNlM{PjJ2Nh?=
SF268 M1Hvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn0cI9oT0l3ME2tOU4{QSCP M2jBb|IzOzN4MkS2
SF295 NXjvOGdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3VSHZ[dG:pR1m1NF0uPi5|NzDN M{SyelIzOzN4MkS2
SF539 M{Pj[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;TTFhtd2eJSUWwQU03NjVyIF2= Mn;VNlI{OzZ{NE[=
SNB75 NHv6cmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULsc4dIUTVyPT23MlExKE1? M12wU|IzOzN4MkS2
SNB78 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHsc4dIUTVyPT22MlUzKE1? MYmyNlM{PjJ2Nh?=
HCC2998 MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofscI9oT0l3ME2tOk4zQSCP MVmyNlM{PjJ2Nh?=
KM12 NEDSSW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG0VJZtd2eJSUWwQU02Njd4IF2= M2rmOFIzOzN4MkS2
HT-29 NI\WUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXqSnRNdG:pR1m1NF0uPi5|MDDN MlzsNlI{OzZ{NE[=
HCT15 NHH5N|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXhdmtKdG:pR1m1NF0uPi5zMjDN Mm\nNlI{OzZ{NE[=
HCT116 NEHkdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr3V2hEdG:pR1m1NF0uPS56NzDN M2\1cFIzOzN4MkS2
NCI-H23 NGCyfmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17qRoxw\0eLNUC9MVUvPzNiTR?= NEfLUYszOjN|NkK0Oi=>
NCI-H226 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDNcI9oT0l3ME2tOk4zOSCP MWiyNlM{PjJ2Nh?=
NCI-H522 NFHnfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:zR2dtd2eJSUWwQU03NjV6IF2= MmTwNlI{OzZ{NE[=
NCI-H483 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnCcI9oT0l3ME2tOk42PiCP NHThUIwzOjN|NkK0Oi=>
A549 M2mxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4bHIxdG:pR1m1NF0uPi5zNTDN NIrUSVczOjN|NkK0Oi=>
DMS273 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfScpZtd2eJSUWwQU03NjR|IF2= NV64eJpuOjJ|M{[yOFY>
DMS114 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXtcVVtd2eJSUWwQU02Njl{IF2= NH7QZY0zOjN|NkK0Oi=>
LOXIMVI NEHK[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDNcI9oT0l3ME2tOk4zQSCP MV6yNlM{PjJ2Nh?=
OVCAR3 M2j5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zpPYxw\0eLNUC9MVYvPzFiTR?= MoDWNlI{OzZ{NE[=
OVCAR4 NEPCNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnsc4dIUTVyPT21Mlc3KE1? NWr5Onc3OjJ|M{[yOFY>
OVCAR5 NXW2OlFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWzcI9oT0l3ME2tOk4zPiCP MVeyNlM{PjJ2Nh?=
OVCAR8 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvsUFdidG:pR1m1NF0uPS55MzDN MmDINlI{OzZ{NE[=
SKOV3 NU\VWWt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q1[oxw\0eLNUC9MVYvPTJiTR?= NHHWcGYzOjN|NkK0Oi=>
RXF631L NHiwZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\IZYxw\0eLNUC9MVYvQDhiTR?= M3yyZlIzOzN4MkS2
ACHN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHyW3Jtd2eJSUWwQU03NjB5IF2= MVuyNlM{PjJ2Nh?=
St-4 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf0T3Ftd2eJSUWwQU02NjV4IF2= M2LC[VIzOzN4MkS2
MKN1 M3v2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfsc4dIUTVyPT23MlA5KE1? MlzTNlI{OzZ{NE[=
MKN7 MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL2eIFsdG:pR1m1NF0uPi53MDDN MmDPNlI{OzZ{NE[=
MKN28 M33JOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DmXoxw\0eLNUC9MVUvPTJiTR?= M2TtSFIzOzN4MkS2
MKN45 NFHZWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;sSlhtd2eJSUWwQU03NjV3IF2= MUKyNlM{PjJ2Nh?=
MKN74 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nlZ4xw\0eLNUC9MVYvODJiTR?= MYCyNlM{PjJ2Nh?=
DU145 MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:5S|Vtd2eJSUWwQU02Njh3IF2= MmjuNlI{OzZ{NE[=
PC3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTsc4dIUTVyPT22MlY3KE1? MYSyNlM{PjJ2Nh?=
ES5 NIHYZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n2bmlEPTB;NUCuNlEhdk1? M{TCe3NCVkeHUh?=
HH MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\S[mlEPTB;MUGxMlA5KG6P MX7TRW5ITVJ?
MHH-PREB-1 NILZRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy0WmhsUUN3ME2xNVQvOyCwTR?= MX\TRW5ITVJ?
NCI-H1770 M37rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF{Mz64OkBvVQ>? M{TnWnNCVkeHUh?=
HuO9 Mkn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjPNXRKSzVyPUKwOk4xOiCwTR?= Mn3sV2FPT0WU
HAL-01 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH1dIROUUN3ME2yNFYvPzNibl2= NX3yXnhkW0GQR1XS
NOS-1 M3vZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzkTWM2OD1{MUGuPFIhdk1? MlrCV2FPT0WU
HGC-27 M3Ha[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\sO|ZKSzVyPUKxNk42PyCwTR?= M2\RTnNCVkeHUh?=
NB69 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfXTWM2OD1{NEWuNlchdk1? M4HLbnNCVkeHUh?=
RS4-11 NYjrdW9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni3TWM2OD1{NkGuO|Yhdk1? M2XUWXNCVkeHUh?=
DOK NXX4c3JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLqTWM2OD1|MEGuO{BvVQ>? MWrTRW5ITVJ?
LB2241-RCC NUntTmlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNyMz64OEBvVQ>? MlPhV2FPT0WU
NCI-H1623 NWDzfnN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm2TWM2OD1|MESuNFghdk1? NFjlNm1USU6JRWK=
YH-13 M3vnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWwRZpGUUN3ME2zNFQvOzJibl2= MXTTRW5ITVJ?
BPH-1 NVPMZmdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNzNDDuUS=> MUfTRW5ITVJ?
AN3-CA NVTrPHBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTN2MD6zO{BvVQ>? NVf2bWN2W0GQR1XS
ES7 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnxWZZKSzVyPUO0NU46QSCwTR?= NWjnXIR3W0GQR1XS
MDA-MB-175-VII M2TnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrHcI1{UUN3ME2zOVIvQTJibl2= Mo\iV2FPT0WU
GAMG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN5MD64OUBvVQ>? MkXJV2FPT0WU
CHL-1 NH7tRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXOSmNUUUN3ME2zO|gvPjVibl2= M2jjb3NCVkeHUh?=
NB7 M1HId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN6OT64N{BvVQ>? MmS5V2FPT0WU
MFE-280 NV30RVhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzO[o1KSzVyPUSxPE4zKG6P MoHpV2FPT0WU
HL-60 MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xrd2lEPTB;NEK1Mlc2KG6P MlH1V2FPT0WU
GCIY NUK3cWlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf2TWM2OD12M{OuPEBvVQ>? MmLZV2FPT0WU
MDA-MB-361 M{X4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj1TWM2OD12M{muNVMhdk1? NU\5e2dmW0GQR1XS
LXF-289 M37NVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH2b|lrUUN3ME20OFgvOjdibl2= MWHTRW5ITVJ?
NBsusSR MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3TWM2OD12OEiuPFUhdk1? NFiyUZVUSU6JRWK=
KU-19-19 M3\RXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTtTWM2OD13MU[uNFchdk1? NYe1UIdPW0GQR1XS
A204 NV3tO45TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nac2lEPTB;NUKyMlM{KG6P NWexeXNnW0GQR1XS
LB1047-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTV{Mj65N{BvVQ>? MlHsV2FPT0WU
COLO-684 NUL2VmFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXXSlBKSzVyPUWyN{4yOSCwTR?= MUHTRW5ITVJ?
PA-1 NEjNd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy0[XFKSzVyPUWzNk41OSCwTR?= M1XUV3NCVkeHUh?=
MG-63 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zEXGlEPTB;NUSxMlEyKG6P MmXsV2FPT0WU
BHT-101 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;rVWlEPTB;NUS0Mlk1KG6P NHS1PFFUSU6JRWK=
NKM-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f1fmlEPTB;NUmzMlA6KG6P MliyV2FPT0WU
T47D NHTPZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XNV2lEPTB;NUm3MlU3KG6P MX3TRW5ITVJ?
MOLT-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;mc5d4UUN3ME22NlMvPjJibl2= M{\ESHNCVkeHUh?=
IGROV-1 NFG0S4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknXTWM2OD14M{SuN|Ehdk1? MmC0V2FPT0WU
ES4 M2TyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:0d2tKSzVyPU[zPU42PCCwTR?= MUHTRW5ITVJ?
HuO-3N1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISwcVFKSzVyPU[0Nk4{QCCwTR?= M3jIZ3NCVkeHUh?=
NEC8 NUH3eFZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLHTWM2OD14NUOuOVchdk1? NWrQXHFbW0GQR1XS
HO-1-N-1 NWHqTY1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTZ3OT6xO{BvVQ>? M3;YUXNCVkeHUh?=
EPCL-272H NVT5SYZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ZR4RKSzVyPU[4O{4zOSCwTR?= M1XJRnNCVkeHUh?=
D-263MG M{\xOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKzZ|hKSzVyPUexPE4yKG6P MkK2V2FPT0WU
MV-4-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n1bWlEPTB;N{K0MlMyKG6P MnjXV2FPT0WU
SK-NEP-1 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K3c2lEPTB;N{K1Mlk1KG6P NXW5cGVOW0GQR1XS
SW872 NWXKTVdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX21b|dUUUN3ME23NlcvQDlibl2= NGrOVWpUSU6JRWK=
P30-OHK MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTRTWM2OD15M{CuO|Ehdk1? MWnTRW5ITVJ?
OMC-1 NIPCSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HCeGlEPTB;N{WxMlA6KG6P Ml;hV2FPT0WU
LoVo M3HLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTd5Nz65JI5O M4S4WnNCVkeHUh?=
LNCaP-Clone-FGC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrHbIFNUUN3ME23PVYvOzRibl2= M4LGOnNCVkeHUh?=
L-363 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrnTWM2OD15OUiuOFIhdk1? M4TBUnNCVkeHUh?=
ES8 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWTXNoUUN3ME24NVAvPTJibl2= NVjWb3l1W0GQR1XS
697 NVzURlZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[0TWM2OD16M{GuOVUhdk1? NFrP[GRUSU6JRWK=
HSC-3 MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLLTWM2OD16M{muOVQhdk1? MXfTRW5ITVJ?
H4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\hcnFKSzVyPUi1NE45PSCwTR?= MYXTRW5ITVJ?
QIMR-WIL M1LiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTh4NT6yJI5O NETpUXNUSU6JRWK=
OAW-42 NHL4RlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTh5Mj6xPUBvVQ>? NG\vN|hUSU6JRWK=
MCF7 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljHTWM2OD16OUiuOVkhdk1? MnfxV2FPT0WU
SCC-25 NIi3WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv5NpVoUUN3ME25NVQvOTlibl2= Ml74V2FPT0WU
NCI-H1563 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLCTWM2OD17MUWuPVkhdk1? MlnmV2FPT0WU
OVCAR-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz5TWM2OD17NECuNVchdk1? M{G5RnNCVkeHUh?=
HDLM-2 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTGTWM2OD17NEmuNkBvVQ>? M{ixRnNCVkeHUh?=
NB5 M1nKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvETFhzUUN3ME25OVYvPiCwTR?= MVPTRW5ITVJ?
NCI-H292 M3m1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPBb3l1UUN3ME25O|QvOzJibl2= MV3TRW5ITVJ?
A101D NInvWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF35S3lKSzVyPUm5NE4yQSCwTR?= MVPTRW5ITVJ?
NCI-H1648 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLKTWM2OD17OUiuOVEhdk1? NUTBb3RiW0GQR1XS
EKVX NWLWW4JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\NPXVKSzVyPUGuNFEzQSEQvF2= NXTBSItlW0GQR1XS
SW1710 NXXSeYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLQWW5QUUN3ME2xMlA1OjN|IN88US=> M{HGV3NCVkeHUh?=
WM-115 NFnBU3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDWS4pKSzVyPUGuNFY3PTZizszN MmTuV2FPT0WU
CAL-54 M4jjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMEewPFEh|ryP M3r4bXNCVkeHUh?=
TGBC24TKB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WyR2lEPTB;MT6wPFA1PSEQvF2= Ml3vV2FPT0WU
NCI-H520 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHiTWM2OD1zLkC4PVY4KM7:TR?= NXjMb4htW0GQR1XS
D-423MG MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHHTWM2OD1zLkC5PVYzKM7:TR?= NHvQTXVUSU6JRWK=
BFTC-905 NGXIPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j4XWlEPTB;MT6xN|Q1QSEQvF2= M1v4RXNCVkeHUh?=
HT MnzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3PTWM2OD1zLkGzOFc5KM7:TR?= MkP4V2FPT0WU
CTB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVztVVZkUUN3ME2xMlE1Ojl|IN88US=> M17Te3NCVkeHUh?=
Hs-578-T M1nvbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ZUGZ[UUN3ME2xMlE6PTZ3IN88US=> MYLTRW5ITVJ?
HuH-7 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;nTWM2OD1zLkKwPVQ6KM7:TR?= NInrS4tUSU6JRWK=
LB996-RCC Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLUTWM2OD1zLkKyNVc4KM7:TR?= MWTTRW5ITVJ?
KYSE-270 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLpWoNuUUN3ME2xMlI6PzN2IN88US=> MYPTRW5ITVJ?
A4-Fuk M2nk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz5Z3ozUUN3ME2xMlI6QTl|IN88US=> MmfZV2FPT0WU
A498 M3viV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy1NFF7UUN3ME2xMlMxPDd2IN88US=> NVf0NVVLW0GQR1XS
SK-MEL-1 M1u4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwM{C2O|kh|ryP MXnTRW5ITVJ?
AU565 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LBSmlEPTB;MT6zNVg3OyEQvF2= MmDUV2FPT0WU
Saos-2 M4DpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvlblZKSzVyPUGuN|MzODVizszN NFjEVYFUSU6JRWK=
A549 MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwM{m5O{DPxE1? M4\vWXNCVkeHUh?=
BFTC-909 M37VOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjzPFFKSzVyPUGuOFM{ODVizszN MoDuV2FPT0WU
MDA-MB-415 M4fWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTFwNEi2PVIh|ryP NEPlSJVUSU6JRWK=
639-V NVW2XnRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:zOZhFUUN3ME2xMlUxOjR3IN88US=> NF7nVnpUSU6JRWK=
A704 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLBTWM2OD1zLkWwO|g2KM7:TR?= M1PuR3NCVkeHUh?=
PANC-03-27 M{LidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwNUG0NFgh|ryP NYHhfZZiW0GQR1XS
SK-MEL-28 M{m3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTSbVlKSzVyPUGuOVYxQDVizszN MnjpV2FPT0WU
Ramos-2G6-4C10 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq3SVdKSzVyPUGuOlA4PDZizszN Moe2V2FPT0WU
HuP-T4 NYe4Uo96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HFWGlEPTB;MT62NFc4QCEQvF2= MlfpV2FPT0WU
VA-ES-BJ NGjsWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTWTWM2OD1zLk[xNlch|ryP NGnDTXpUSU6JRWK=
EFM-19 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwNkG4NUDPxE1? MnvXV2FPT0WU
G-401 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrHVIVpUUN3ME2xMlYzOTZ2IN88US=> MULTRW5ITVJ?
D-566MG NGH1T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n3fGlEPTB;MT62NlU{KM7:TR?= NWizNpVxW0GQR1XS
JVM-3 NEX3XYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNkS4O|Uh|ryP MYXTRW5ITVJ?
TK10 NYPMXpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLSO5FOUUN3ME2xMlY4ODh|IN88US=> NH;tNmxUSU6JRWK=
BT-20 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jjXmlEPTB;MT62PFkxOiEQvF2= M4DZOnNCVkeHUh?=
EGI-1 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PG[WlEPTB;MT64OFcxOSEQvF2= MUjTRW5ITVJ?
EW-16 MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHaeVJHUUN3ME2xMlg2OTh{IN88US=> NF3KUWFUSU6JRWK=
NCI-H2228 NV3NWmJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KxcWlEPTB;MT64OVIxOyEQvF2= M1TPRXNCVkeHUh?=
BB49-HNC NF\yb2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TXeGlEPTB;MT64PFY6OiEQvF2= MknaV2FPT0WU
G-402 MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFwOEm3PVch|ryP MmPIV2FPT0WU
NCI-H526 MmiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFwOUGzPUDPxE1? MYTTRW5ITVJ?
ME-180 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwOUO0O|ch|ryP NF7ofWVUSU6JRWK=
PFSK-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TMd2lEPTB;MT65OFQ2QCEQvF2= MX7TRW5ITVJ?
TYK-nu MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf4S5VUUUN3ME2xMlk2QDJ|IN88US=> NU\WTHN{W0GQR1XS
HOS MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ewVmlEPTB;MT65O|k1QCEQvF2= M3XJOXNCVkeHUh?=
T98G NEPETFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPMV5hKSzVyPUGuPVkxODZizszN NFvoNYxUSU6JRWK=
SK-MES-1 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\ITGlEPTB;Mj6wNVM{OiEQvF2= M17oS3NCVkeHUh?=
SNB75 M4jxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rtcmlEPTB;Mj6wNVU1OSEQvF2= MWPTRW5ITVJ?
LAMA-84 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLvcHpKSzVyPUKuNFI3QDlizszN NVHn[5hIW0GQR1XS
CAL-39 M2DUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDE[GpKSzVyPUKuNFMzQCEQvF2= Mlv3V2FPT0WU
LOXIMVI NFziWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT0TWM2OD1{LkC0NFg1KM7:TR?= M4HUOHNCVkeHUh?=
NH-12 NUjZR4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJwMEW0NlQh|ryP MmjvV2FPT0WU
NCI-H1048 NV\1UmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfKbpN{UUN3ME2yMlExPTJizszN NYTkdZBDW0GQR1XS
KS-1 NFHtTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS3TWM2OD1{LkGxNFAyKM7:TR?= MXjTRW5ITVJ?
NCI-N87 NHi2cXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS2TWM2OD1{LkGzN|g1KM7:TR?= M3W4XXNCVkeHUh?=
CHP-212 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj0THZbUUN3ME2yMlE5PDR{IN88US=> M{XzNHNCVkeHUh?=
HCC1419 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLhTWM2OD1{LkKxNVE2KM7:TR?= M325R3NCVkeHUh?=
ES1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7DN3BKSzVyPUKuNlE{OjZizszN M{PTXnNCVkeHUh?=
NCI-H2030 M{\jZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[wOGNKSzVyPUKuNlQyOjNizszN NWS1[495W0GQR1XS
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EW-13 M3HIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULLWWVIUUN3ME23Mlg6QTd5IN88US=> NHrEfJJUSU6JRWK=
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TE-12 NGDCTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLKO4tRUUN3ME24Mlc4PTB3IN88US=> NF;J[2hUSU6JRWK=
DBTRG-05MG M3j6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\aNWlEPTB;OD65NVIyPyEQvF2= Mne3V2FPT0WU
KINGS-1 M4jCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW5UFJHUUN3ME24MlkzQTN6IN88US=> MYrTRW5ITVJ?
HLE M1rlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDzW3FRUUN3ME24Mlk{Pzh3IN88US=> NFP0TWxUSU6JRWK=
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D-247MG MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\iTYdNUUN3ME2xNE4xPTZ6IN88US=> MV;TRW5ITVJ?
MPP-89 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFyLkC5OFYh|ryP NIm4TWZUSU6JRWK=
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NCI-H460 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f1fmlEPTB;MUCuNlgxPiEQvF2= M1vl[3NCVkeHUh?=
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HT55 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFyLk[yNFUh|ryP M1jEWXNCVkeHUh?=
MC116 M3n0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvuOHc2UUN3ME2xNE43PjV3IN88US=> MkfuV2FPT0WU
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MSTO-211H NH;qbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXjTZNDUUN3ME2xNU4xPzF4IN88US=> NF2xO3dUSU6JRWK=
SW837 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTYTWM2OD1zMT6wPVQ6KM7:TR?= MV\TRW5ITVJ?
HuCCT1 NY\ZZ4ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFzLkGyPFEh|ryP MoXOV2FPT0WU
RCC10RGB NXq5OlJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPldG9KSzVyPUGxMlE{PSEQvF2= NXP1d2N[W0GQR1XS
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EW-11 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS2VoNzUUN3ME2xNU46PDd2IN88US=> MUXTRW5ITVJ?
LB2518-MEL NFq5b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF{LkC1PUDPxE1? M{H1cnNCVkeHUh?=
KALS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC5ZYlsUUN3ME2xNk45PTV|IN88US=> NGXxOWtUSU6JRWK=
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OCUB-M NH7CcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fmNmlEPTB;MUOuPFE2PiEQvF2= NVTyR5RRW0GQR1XS
SW982 M4\5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF|LkiyO|Yh|ryP MULTRW5ITVJ?
DB MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjiTWM2OD1zMz64N|g1KM7:TR?= NX;RXW5mW0GQR1XS
H-EMC-SS NIXCN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF|LkmxN|kh|ryP MlPXV2FPT0WU
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CAKI-1 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe2U4VKSzVyPUG0MlAyOzJizszN NVm2dolKW0GQR1XS
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Ca9-22 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nPVmlEPTB;MUSuOlA2PCEQvF2= M{PZXnNCVkeHUh?=
TE-5 NWjhN3lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfPbG5qUUN3ME2xOE44OjB6IN88US=> MXrTRW5ITVJ?
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CAL-72 NF;lOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF2Lke3PFMh|ryP M4DpN3NCVkeHUh?=
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CAS-1 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3KTWM2OD1zNT6wOlYh|ryP NGTEZXRUSU6JRWK=
A2058 M{LTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXsWIN{UUN3ME2xOU42PjN6IN88US=> Moi3V2FPT0WU
PANC-08-13 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LHfGlEPTB;MUWuOlg2QSEQvF2= NXzuZ5J5W0GQR1XS
Detroit562 NWXwdmtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\qNYtKSzVyPUG1MlkyOzlizszN NIPZfIhUSU6JRWK=
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GT3TKB NInVNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi4OXpKSzVyPUG2MlE6QDFizszN MnLpV2FPT0WU
KM-H2 MlHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DiRmlEPTB;MU[uN|Y1PiEQvF2= NGfRV41USU6JRWK=
LB771-HNC NXnQXlFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLqTWM2OD1zNj60OFIzKM7:TR?= NV3qN5UyW0GQR1XS
SF268 M3n4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF4LkS1NkDPxE1? M1u3[nNCVkeHUh?=
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MDA-MB-231 NUm1OFhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHsTWM2OD1zNj63NVM3KM7:TR?= M{jFWHNCVkeHUh?=
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MDA-MB-453 NH;4UXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHWVXRKSzVyPUG3MlAxODNizszN MkDFV2FPT0WU
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NUGC-3 NGn6XmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\CNI9KSzVyPUG4MlY2QDRizszN MnLIV2FPT0WU
BB65-RCC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF6Lk[2PUDPxE1? NXHGUXFVW0GQR1XS
RMG-I M3;0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\VTWM2OD1zOD63N|gzKM7:TR?= MYHTRW5ITVJ?
LS-513 NYXRV2VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnHXWZKSzVyPUG4MlkzOjhizszN MV7TRW5ITVJ?
MFM-223 NGj0Z4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfPTWM2OD1zOT6wO|E3KM7:TR?= MX\TRW5ITVJ?
NCI-H727 M1OzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPOdmZKSzVyPUG5MlMzQTVizszN MojxV2FPT0WU
KP-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlGwTWM2OD1zOT64OVMyKM7:TR?= NF\QNFFUSU6JRWK=
NB13 MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXmTWM2OD1zOT64PFM6KM7:TR?= MniyV2FPT0WU
UACC-893 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlewTWM2OD1zOT65O|U4KM7:TR?= M3zsOXNCVkeHUh?=
HT-1197 NH7ZOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITMdIFKSzVyPUKwMlI6PThizszN M{DOW3NCVkeHUh?=
NCI-H2029 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHZTWM2OD1{MD6zNlY3KM7:TR?= MmCyV2FPT0WU
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OVCAR-3 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TUPGlEPTB;MkCuOVgzOiEQvF2= MXjTRW5ITVJ?
HD-MY-Z NEfFWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJzLkO2PVYh|ryP M4qxRXNCVkeHUh?=
NTERA-S-cl-D1 M{XPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjNU25KSzVyPUKxMlY4OjJizszN M{X1d3NCVkeHUh?=
SCH M3[xfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS5NlRWUUN3ME2yNk41QTZizszN MnPDV2FPT0WU
KARPAS-299 M1HOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq2WG5KSzVyPUKzMlM5QDdizszN NGPKN5VUSU6JRWK=
NCI-H1650 M2DvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\z[plkUUN3ME2yN{46OjRzIN88US=> M1q1OnNCVkeHUh?=
ACHN MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP1TWM2OD1{ND60OlU3KM7:TR?= NEmzPXpUSU6JRWK=
M059J NWX0b|RTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTVdXdyUUN3ME2yOE42PjN2IN88US=> NYKzOWduW0GQR1XS
AM-38 NWLjW2U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD0TWM2OD1{NT60PFEh|ryP MXnTRW5ITVJ?
KG-1 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ3LkW0PVQh|ryP MWHTRW5ITVJ?
COLO-824 MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O2NmlEPTB;MkWuOVU6QSEQvF2= MYHTRW5ITVJ?
NCI-H1155 NY\I[Wo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PYUGlEPTB;MkWuOVg1PyEQvF2= MnHKV2FPT0WU
NCI-H441 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nSbGlEPTB;MkWuO|Q3PSEQvF2= M{\kNnNCVkeHUh?=
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JEG-3 NIjxRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjxTWM2OD1{Nj62PFA2KM7:TR?= M1XlO3NCVkeHUh?=
RKO M16ydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjTfG1JUUN3ME2yOk44PjN{IN88US=> M4mwcHNCVkeHUh?=
CAL-85-1 NGroTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe1d|NKSzVyPUK3MlIyOThizszN MmDHV2FPT0WU
CAL-120 M13MVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rYWWlEPTB;MkeuOlkyPCEQvF2= NET3[nlUSU6JRWK=
NCI-H2452 NYD3b3UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILQZ5VKSzVyPUK3Mlc4OTZizszN NI\mSXZUSU6JRWK=
NCI-H1395 NGHYTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GyRWlEPTB;MkeuO|g{OyEQvF2= MUnTRW5ITVJ?
KYSE-450 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfwPFRrUUN3ME2yO{46QDZ{IN88US=> M{nu[HNCVkeHUh?=
S-117 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJ7LkO4OVch|ryP NVTaNZFvW0GQR1XS
SW13 M3Tmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH32SY5KSzVyPUK5Mlg2OTlizszN MXXTRW5ITVJ?
ES3 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jTVWlEPTB;M{CuN|c{OyEQvF2= MoS3V2FPT0WU
HCT-116 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLPTWM2OD1|MD61OVU1KM7:TR?= NFmzSppUSU6JRWK=
NCI-H1693 NVnNbpBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfwTWM2OD1|MD61PVQzKM7:TR?= M2TZb3NCVkeHUh?=
VM-CUB-1 NUPkSVJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPXU4dKSzVyPUOwMlY1OTNizszN M4LNNXNCVkeHUh?=
NCI-H2170 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DDSWlEPTB;M{GuOVc5PCEQvF2= Mn7hV2FPT0WU
ALL-PO NUXWNpY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmwTWM2OD1|MT64OFI5KM7:TR?= MV;TRW5ITVJ?
NCI-H661 M1vnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u1e2lEPTB;M{KuNFYzOyEQvF2= Mnn2V2FPT0WU
NCI-H2347 M4jVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrnTWM2OD1|Mj60PFM4KM7:TR?= NEDHNItUSU6JRWK=
FTC-133 NGX6UlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTN{LkewOkDPxE1? MoDnV2FPT0WU
COLO-829 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\tTWM2OD1|Mz6zOFY4KM7:TR?= NHy5SJZUSU6JRWK=
GOTO Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN|LkWyOVgh|ryP M4PMe3NCVkeHUh?=
YAPC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnsTZJKSzVyPUOzMlgyPTlizszN MYXTRW5ITVJ?
LCLC-103H MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC1TWM2OD1|ND6xOlI1KM7:TR?= MWrTRW5ITVJ?
SiHa MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rSNGlEPTB;M{SuN|gyPyEQvF2= M2CzenNCVkeHUh?=
LK-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DrV2lEPTB;M{SuOVcxQCEQvF2= MnO5V2FPT0WU
KP-N-YS MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf0UZJqUUN3ME2zOE44OjB{IN88US=> NUTFVnNmW0GQR1XS
NCI-SNU-1 M3nWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;yZ|NKSzVyPUO1MlE4QSEQvF2= MkPNV2FPT0WU
KNS-81-FD MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33DTWlEPTB;M{WuOlY{KM7:TR?= MlfnV2FPT0WU
SCC-9 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVZ2lEPTB;M{[uO|E1PiEQvF2= MYXTRW5ITVJ?
SH-4 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHxdplKSzVyPUO2Mlc{KM7:TR?= NVzSOlltW0GQR1XS
HCC-1954 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr5[483UUN3ME2zO{4zPzJ7IN88US=> NWPHTYhOW0GQR1XS
BALL-1 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3wVlJUUUN3ME2zO{42OzF4IN88US=> M1j5WnNCVkeHUh?=
BE-13 NGnkRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4roZWlEPTB;M{euO|AyQCEQvF2= NEfKTVFUSU6JRWK=
COLO-678 NYXEflNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELNU21KSzVyPUO3Mlk1OzdizszN NVvFc4VQW0GQR1XS
SK-MEL-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v6RWlEPTB;M{iuNlM6PyEQvF2= MlX5V2FPT0WU
OAW-28 NFvkS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K2fWlEPTB;M{iuOlM6KM7:TR?= M3XxW3NCVkeHUh?=
CAMA-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN6Lkm2PVEh|ryP NYqzZoVsW0GQR1XS
C2BBe1 NHHCbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\vXWNHUUN3ME2zPU45OThizszN NVKyOVdYW0GQR1XS
A3-KAW NYPSZ|VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTRyLkO2OlEh|ryP MU\TRW5ITVJ?
SK-MEL-24 NH;BU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\rTWM2OD12MD61PVMyKM7:TR?= NXnLTWVSW0GQR1XS
KYSE-140 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jlTGlEPTB;NECuO|E3PSEQvF2= MmDwV2FPT0WU
MOLT-16 NFrYfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP6TWM2OD12MT6xOVM3KM7:TR?= MkfqV2FPT0WU
CFPAC-1 M4nhfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTR{LkWyNVEh|ryP NIPXfIhUSU6JRWK=
NB14 M1zqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzqc3Z2UUN3ME20Nk44ODJ5IN88US=> NVjBOm5CW0GQR1XS
COLO-792 NHHKNFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjFTWM2OD12Mj64PVYyKM7:TR?= MnvaV2FPT0WU
RH-1 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR|LkS4N|Yh|ryP NGXkS45USU6JRWK=
NCI-H522 M37IbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\L[mlEPTB;NESuN|U3QCEQvF2= NIPkR4hUSU6JRWK=
Ca-Ski MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrZc5ZKSzVyPUS0MlgyOTRizszN NIfvd2JUSU6JRWK=
KGN NUTHRVJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLL[Zk{UUN3ME20PE4{ODZ|IN88US=> MYjTRW5ITVJ?
UACC-62 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHMTYpKSzVyPUS4MlQxPzJizszN MWPTRW5ITVJ?
NCI-H358 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYTWM2OD12OT6zNFE5KM7:TR?= MXrTRW5ITVJ?
LS-411N NELLbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\MWotKSzVyPUS5MlMyOThizszN M4DhZnNCVkeHUh?=
IST-MES1 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTR7LkW2NlUh|ryP M1zOVnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID