Pictilisib (GDC-0941)

For research use only. Not for use in humans.

Catalog No.S1065 Synonyms: RG7321

294 publications

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Selleck's Pictilisib (GDC-0941) has been cited by 294 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MlzGT4lv[XOnIFHzd4F6 NEX5V3EyKGh? NX7W[G9FTE2VTx?= MmS2TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP NGm4coQyQDd3NE[1OC=>
Sf9 MXTLbY5ie2ViQYPzZZk> NHTyR5gyKGh? NV7kTYNvTE2VTx?= NYD1fFIxUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEhzMES3MXIhdXW2YX70JIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? M{PLSFE5PzV2NkW0
Sf9 NFe3PXVMcW6jc3WgRZN{[Xl? NXKxbYxyOSCq M4TMVGROW09? NVHXfVBjUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEV3NEWtT{BufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? MXGxPFc2PDZ3NB?=
Sf9 NYO1[IRpU2mwYYPlJGF{e2G7 MUmxJIg> NXvWWXdQTE2VTx?= MoDtTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? MkXsNVg4PTR4NUS=
Sf9 NUHrPZFFU2mwYYPlJGF{e2G7 NWPUOXA1OSCq NYXwUYlkTE2VTx?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGGucHjhJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjh M3TNcVE5PzV2NkW0
MDA-MB-361 NGrKfXlHfW6ldHnvckBCe3OjeR?= NWWwbphOOiCq M3Py[GROW09? MnPWTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN MVOxPFc2PDZ3NB?=
PC3 NIDCRlNHfW6ldHnvckBCe3OjeR?= MoHXNkBp NV7FRXYzTE2VTx?= NWTyell[UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? NHja[mcyQDd3NE[1OC=>
U87MG Mo[5SpVv[3Srb36gRZN{[Xl? NWrWVWJmOiCq MonYSG1UVw>? NELLdY1KdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP NEj4OYQyQDd3NE[1OC=>
MDA-MB-361 NImyNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:0PVYhcA>? MWDEUXNQ M2nFc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvPzJizszN M{m2b|E5PzV2NkW0
A2780 M13KOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\UXYhVQTZiaB?= M4DEUWROW09? NYKwTGZrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= Ml;wNVg4PTR4NUS=
PC3 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOwPVYhcA>? NWCx[2lvTE2VTx?= NG\IXFFKSzVyPUCuNlgh|ryP M1ywW|E5PzV2NkW0
U87MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTEPVYhcA>? M4m5PGROW09? NUnwcWVSUUN3ME2wMlk2KM7:TR?= NIfyVlMyQDd3NE[1OC=>
Sf9 MXvLbY5ie2ViQYPzZZk> MlnxN|AhdWmw NYTNW5RPTE2VTx?= MmjuTY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHHtc5VvfCCxZjDBWHAh[2:wc4Xt[YQhf2m2aDDJR|UxKG:oIECuNFQzKM7:TR?= M1\kfVIzPTR6M{Sy
RAW 264.7 M1jpZWtqdmG|ZTDBd5NigQ>? NInhO3E6OCCvaX6= MmjsSG1UVw>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= M{W4PFIzPTR6M{Sy
Sf9 M4q3bGtqdmG|ZTDBd5NigQ>? MUixJIg> MVrJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW0Z7IHPlcIx{KHerdHigTWM2OCCxZjCwMlAyPyEQvF2= MkPCNlM2PDB4NEW=
Sf9 NWG2OXNLU2mwYYPlJGF{e2G7 M1KwSVEhcA>? MnrUTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4RmdHSjIHX4dJJme3OnZB?= Mkn6NlM2PDB4NEW=
Sf9 M1TidmtqdmG|ZTDBd5NigQ>? NFTMUIUyKGh? Mni5TY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= NWL1S4VxOjN3NEC2OFU>
Sf9 NG\Cd|lMcW6jc3WgRZN{[Xl? M3va[lEhcA>? MXLJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZYxxcGFiZYjwdoV{e2Wm M3\BcFI{PTRyNkS1
SKOV3 NHrtVWJMcW6jc3WgRZN{[Xl? NX7Xc25WOSEQvF2= M13HSlEhcA>? M1PU[mROW09? MWHJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9v M4PDXFI{OzZyM{S4
MCF7 NF25SHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrJXZI4OSEQvF2= MmDjPVYhcA>? NV:yOo9sTE2VTx?= M3LGXWdKPTB;MD6wO|AzKM7:TR?= NVn3fGpKOjN|NkCzOFg>
SKOV3 M2Xsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUixJO69VQ>? MlrPPVYhcA>? M1PGd2ROW09? MlrsS2k2OD1yLkG0O|Yh|ryP NVTLSG1NOjN|NkCzOFg>
PC3 NHOwU2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PPc|czKGh? M3fLTmROW09? M1fKVWlEPTB;MD6yPEDPxE1? MlrONlE6QDF5MUS=
MCF7.1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnNZVE4OiCq NHn0fpZFVVOR M3G0TmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochUEWUMjDn[Y5mKHerdHigTWM2OCCxZjCwMlI5KM7:TR?= M{D2W|IyQThzN{G0
MCF7-neo/Her2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\BO|IhcA>? NGrneoVFVVOR MVjJR|UxRTBwMkmg{txO NV33eINQOjN4NkK5NFM>
MCF7-neo/Her2 NUjSN2plU2mwYYPlJGF{e2G7 MkD4TY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN NWTrO3AyOjN4NkK5NFM>
PC3 NUnTcoxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTOfVI4OiCq MXjEUXNQ NEDGOodGSzVyPUCuN|Qh|ryP NFrNOJkzOTl6NU[zPS=>
MCF7.1 M4PQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f3dlczKGh? M3vlSGROW09? MnHuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? NX7jfXF1OjF7OEW2N|k>
PC3 NWDkV4psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnvbVdjPzJiaB?= NWjyXXJ5TE2VTx?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= Mn:1NlAxPTB4Nkm=
MCF7.1 M1O0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVK3NkBp MV3EUXNQ Ml3DRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? NEDre|AzODB3ME[2PS=>
MCF7.1 M4eyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjHO|IhcA>? MYXFR|UxRTBwN{Kg{txO MWOyNFM1PjZ3Nh?=
NCI-H1975 MVnDfZRwfG:6aXOgRZN{[Xl? NWDX[VdMPzJiaB?= NHewS2VKSzVyPUCuNlch|ryP M1nPXVI{ODV7NUS1
H460 Ml;4R5l1d3SxeHnjJGF{e2G7 NHvlOW04OiCq NFTDXW9KSzVyPUCuPFch|ryP M2PGbVI{ODV7NUS1
HT-29 NF6yUo1EgXSxdH;4bYMhSXO|YYm= MoKwO|IhcA>? MnK4TWM2OD1yLk[2JO69VQ>? NXHLXppkOjNyNUm1OFU>
HepG2 NYLLNFFKS3m2b4TvfIlkKEG|c3H5 NYnZXmpEPzJiaB?= MYXJR|UxRTFizszN MmrjNlMxPTl3NEW=
SGC7901 M4HsO2N6fG:2b4jpZ{BCe3OjeR?= M3PvVlczKGh? M33yU2lEPTB;MT64JO69VQ>? MVmyN|A2QTV2NR?=
NCI-H226 NWXJZZVzS3m2b4TvfIlkKEG|c3H5 MUS3NkBp NV\xRlE4UUN3ME2yMlkh|ryP NUPQR2plOjNyNUm1OFU>
A549 M1GxTWN6fG:2b4jpZ{BCe3OjeR?= MXK3NkBp MYjJR|UxRTZwOTFOwG0> NVLZV2Z[OjNyNUm1OFU>
U87MG M1P1XGN6fG:2b4jpZ{BCe3OjeR?= NIXZ[4U4OiCq NULKbohCUUN3ME23Mlc4KM7:TR?= MkXrNlMxPTl3NEW=
HBC4 NGnG[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;JcI9oT0l3ME2tOk4xOyCP MkHHNlI{OzZ{NE[=
BSY1 M13wWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrzcI9oT0l3ME2tOk46OCCP M1fwcFIzOzN4MkS2
HBC5 NWO3ToFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\2TJRPdG:pR1m1NF0uPi54MDDN NXztUYQ5OjJ|M{[yOFY>
MCF7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfzN2Vtd2eJSUWwQU04NjN|IF2= NXP3Z3JtOjJ|M{[yOFY>
MDA-MB-231 M3vTcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX3WJdsdG:pR1m1NF0uPS52NjDN M4DzSVIzOzN4MkS2
U251 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\sc4dIUTVyPT21MlUxKE1? M3m5OVIzOzN4MkS2
SF268 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXiU5Ntd2eJSUWwQU02NjN7IF2= NFO2PGQzOjN|NkK0Oi=>
SF295 NXrJ[2tkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HGW4xw\0eLNUC9MVYvOzdiTR?= MnvhNlI{OzZ{NE[=
SF539 MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTsc4dIUTVyPT22MlUxKE1? M3LpS|IzOzN4MkS2
SNB75 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f1TYxw\0eLNUC9MVcvOTBiTR?= NX3yXYU{OjJ|M{[yOFY>
SNB78 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHsc4dIUTVyPT22MlUzKE1? NGTPcHIzOjN|NkK0Oi=>
HCC2998 NI[5bndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33GeYxw\0eLNUC9MVYvOjliTR?= NFGwXW0zOjN|NkK0Oi=>
KM12 NWGxbVBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnjcI9oT0l3ME2tOU44PiCP MX2yNlM{PjJ2Nh?=
HT-29 NIjSSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;yUoxw\0eLNUC9MVYvOzBiTR?= MXiyNlM{PjJ2Nh?=
HCT15 NYfKNohIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjsc4dIUTVyPT22MlEzKE1? NF;K[WwzOjN|NkK0Oi=>
HCT116 NX3CXXdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe3eZVkdG:pR1m1NF0uPS56NzDN NWCzTY05OjJ|M{[yOFY>
NCI-H23 NWTVRWpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PDNYxw\0eLNUC9MVUvPzNiTR?= M4W4flIzOzN4MkS2
NCI-H226 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrsc4dIUTVyPT22MlIyKE1? NVe2fmdrOjJ|M{[yOFY>
NCI-H522 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13uR4xw\0eLNUC9MVYvPThiTR?= NVPHWINKOjJ|M{[yOFY>
NCI-H483 NV3ES4M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfsc4dIUTVyPT22MlU3KE1? NEHkNW8zOjN|NkK0Oi=>
A549 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ucI9oT0l3ME2tOk4yPSCP NVnl[HRLOjJ|M{[yOFY>
DMS273 NVvCWJFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjMO|FodG:pR1m1NF0uPi52MzDN M4rRVVIzOzN4MkS2
DMS114 NUGyZ2RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjsc4dIUTVyPT21MlkzKE1? Mn\4NlI{OzZ{NE[=
LOXIMVI MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfvXGxEdG:pR1m1NF0uPi5{OTDN MWKyNlM{PjJ2Nh?=
OVCAR3 M37HN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jzV4xw\0eLNUC9MVYvPzFiTR?= NWnIW21ZOjJ|M{[yOFY>
OVCAR4 NYjGNJY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[2SXhodG:pR1m1NF0uPS55NjDN MYeyNlM{PjJ2Nh?=
OVCAR5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\6VYxw\0eLNUC9MVYvOjZiTR?= Mo\HNlI{OzZ{NE[=
OVCAR8 NVnmTWNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[0cI9oT0l3ME2tOU44OyCP NEXqToUzOjN|NkK0Oi=>
SKOV3 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Do[Ixw\0eLNUC9MVYvPTJiTR?= M37leFIzOzN4MkS2
RXF631L MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr5THlCdG:pR1m1NF0uPi56ODDN NHzQT2MzOjN|NkK0Oi=>
ACHN NVniW4hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvKbYRjdG:pR1m1NF0uPi5yNzDN NIXMdHozOjN|NkK0Oi=>
St-4 M3\Sfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XdVlPdG:pR1m1NF0uPS53NjDN MX6yNlM{PjJ2Nh?=
MKN1 NG\CSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3jTG0ydG:pR1m1NF0uPy5yODDN NYCye5NtOjJ|M{[yOFY>
MKN7 M1:3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvocI9oT0l3ME2tOk42OCCP MUSyNlM{PjJ2Nh?=
MKN28 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorncI9oT0l3ME2tOU42OiCP MmHINlI{OzZ{NE[=
MKN45 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3lNZlUdG:pR1m1NF0uPi53NTDN NE\SOGgzOjN|NkK0Oi=>
MKN74 NIfFb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrsc4dIUTVyPT22MlAzKE1? MWeyNlM{PjJ2Nh?=
DU145 M2jidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;KT|dtd2eJSUWwQU02Njh3IF2= M4T6OFIzOzN4MkS2
PC3 M4PWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorCcI9oT0l3ME2tOk43PiCP NVjJeGVmOjJ|M{[yOFY>
ES5 NH24ZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTVyLkKxJI5O M3Xq[XNCVkeHUh?=
HH MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv3dINmUUN3ME2xNVEvODhibl2= M1vSZ3NCVkeHUh?=
MHH-PREB-1 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvvTWM2OD1zMUSuN{BvVQ>? MmnJV2FPT0WU
NCI-H1770 NX3VOZBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLVTWM2OD1zMkOuPFYhdk1? MYPTRW5ITVJ?
HuO9 NGnCRmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vjNGlEPTB;MkC2MlAzKG6P MXrTRW5ITVJ?
HAL-01 M3PDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJyNj63N{BvVQ>? MYPTRW5ITVJ?
NOS-1 NULad2xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjEN5kzUUN3ME2yNVEvQDJibl2= Ml7qV2FPT0WU
HGC-27 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1raWGlEPTB;MkGyMlU4KG6P NYPJZ3FsW0GQR1XS
NB69 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HwVWlEPTB;MkS1MlI4KG6P MXnTRW5ITVJ?
RS4-11 M1nBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nsRmlEPTB;Mk[xMlc3KG6P MYjTRW5ITVJ?
DOK MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLONYdKSzVyPUOwNU44KG6P M2r5ZnNCVkeHUh?=
LB2241-RCC M{PLTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy4PJdKSzVyPUOwN{45PCCwTR?= NV3BeYdXW0GQR1XS
NCI-H1623 NIHtc5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNyND6wPEBvVQ>? MUDTRW5ITVJ?
YH-13 M3ixSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTNyND6zNkBvVQ>? NXizSGk3W0GQR1XS
BPH-1 NID6VYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37wUWlEPTB;M{G0JI5O NHjGXVVUSU6JRWK=
AN3-CA NX\qepJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnEeW5LUUN3ME2zOFAvOzdibl2= MkXlV2FPT0WU
ES7 NIP6U|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO5dY52UUN3ME2zOFEvQTlibl2= MX7TRW5ITVJ?
MDA-MB-175-VII MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSyNnVHUUN3ME2zOVIvQTJibl2= NEfGWXlUSU6JRWK=
GAMG MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULFdWlnUUN3ME2zO|AvQDVibl2= MWTTRW5ITVJ?
CHL-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXWTWM2OD1|N{iuOlUhdk1? MUHTRW5ITVJ?
NB7 NEPifoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorETWM2OD1|OEmuPFMhdk1? NUnCUnZrW0GQR1XS
MFE-280 MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXRbnhqUUN3ME20NVgvOiCwTR?= MVTTRW5ITVJ?
HL-60 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR{NT63OUBvVQ>? M{HqenNCVkeHUh?=
GCIY NUnvRWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\K[2RKSzVyPUSzN{45KG6P MUHTRW5ITVJ?
MDA-MB-361 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PMbmlEPTB;NEO5MlE{KG6P MoPGV2FPT0WU
LXF-289 M1jaemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;tVmlEPTB;NES4MlI4KG6P NIDXbJVUSU6JRWK=
NBsusSR NWLPZVF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3jfIdvUUN3ME20PFgvQDVibl2= MnrDV2FPT0WU
KU-19-19 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTVzNj6wO{BvVQ>? NUTZdlM3W0GQR1XS
A204 NXn3UlZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7Q[pJKSzVyPUWyNk4{OyCwTR?= M37aWHNCVkeHUh?=
LB1047-RCC NGfmWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDjTWM2OD13MkKuPVMhdk1? M13uc3NCVkeHUh?=
COLO-684 MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP0TWM2OD13MkOuNVEhdk1? M3nMWnNCVkeHUh?=
PA-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DFWmlEPTB;NUOyMlQyKG6P NGXh[phUSU6JRWK=
MG-63 M2XqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrtbHl{UUN3ME21OFEvOTFibl2= MkDGV2FPT0WU
BHT-101 M1;TeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILnTWtKSzVyPUW0OE46PCCwTR?= MVzTRW5ITVJ?
NKM-1 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LtfGlEPTB;NUmzMlA6KG6P M4LIe3NCVkeHUh?=
T47D MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK3TXRLUUN3ME21PVcvPTZibl2= NYDC[21RW0GQR1XS
MOLT-4 M2DvOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH0Z4ZKSzVyPU[yN{43OiCwTR?= MmHoV2FPT0WU
IGROV-1 NGS5PIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O5cGlEPTB;NkO0MlMyKG6P NWPrUGJLW0GQR1XS
ES4 MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Ozb2lEPTB;NkO5MlU1KG6P NU\uc21IW0GQR1XS
HuO-3N1 NEnBNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZ2Mj6zPEBvVQ>? M4H1dXNCVkeHUh?=
NEC8 M3rTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLjTWM2OD14NUOuOVchdk1? MUjTRW5ITVJ?
HO-1-N-1 NHnzVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTZ3OT6xO{BvVQ>? NFjP[XpUSU6JRWK=
EPCL-272H Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rEb2lEPTB;Nki3MlIyKG6P M33jdnNCVkeHUh?=
D-263MG M3TESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTdzOD6xJI5O NHLiOZJUSU6JRWK=
MV-4-11 M1S3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLj[nlKSzVyPUeyOE4{OSCwTR?= NX[wSIpLW0GQR1XS
SK-NEP-1 NV:yZmU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDYT2dGUUN3ME23NlUvQTRibl2= MWHTRW5ITVJ?
SW872 NVzHb3RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\IbmVEUUN3ME23NlcvQDlibl2= NHHudZFUSU6JRWK=
P30-OHK MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHzTWM2OD15M{CuO|Ehdk1? Mm\UV2FPT0WU
OMC-1 NEj2RolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ixRWlEPTB;N{WxMlA6KG6P MWDTRW5ITVJ?
LoVo NGjCNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCxW|huUUN3ME23O|cvQSCwTR?= M4H6THNCVkeHUh?=
LNCaP-Clone-FGC NUXOSItwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HzdWlEPTB;N{m2MlM1KG6P NYXhTZhYW0GQR1XS
L-363 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;rWWlEPTB;N{m4MlQzKG6P M1S4WXNCVkeHUh?=
ES8 NX2xUphsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zje2lEPTB;OEGwMlUzKG6P MnjPV2FPT0WU
697 NYWwcIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH4SFV6UUN3ME24N|EvPTVibl2= NYXoU5ZpW0GQR1XS
HSC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTh|OT61OEBvVQ>? NFnmeHRUSU6JRWK=
H4 NEjhdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTh3MD64OUBvVQ>? M2O1bXNCVkeHUh?=
QIMR-WIL M3PidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S3WWlEPTB;OE[1MlIhdk1? MUTTRW5ITVJ?
OAW-42 M2HJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7lW2QxUUN3ME24O|IvOTlibl2= MVTTRW5ITVJ?
MCF7 NU\TU29QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\ud2lEPTB;OEm4MlU6KG6P M4riVHNCVkeHUh?=
SCC-25 NXOzW2R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LRSWlEPTB;OUG0MlE6KG6P MWfTRW5ITVJ?
NCI-H1563 NXuwPHZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorsTWM2OD17MUWuPVkhdk1? Mnr4V2FPT0WU
OVCAR-5 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ywRWlEPTB;OUSwMlE4KG6P MkH2V2FPT0WU
HDLM-2 NXOz[25UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLpTWM2OD17NEmuNkBvVQ>? NXK3NYNUW0GQR1XS
NB5 NHvE[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LUWmlEPTB;OUW2MlYhdk1? MnLkV2FPT0WU
NCI-H292 MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rBOmlEPTB;OUe0MlMzKG6P NVW4dlR{W0GQR1XS
A101D Mn7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HhWmlEPTB;OUmwMlE6KG6P MXHTRW5ITVJ?
NCI-H1648 NU\zXXBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjOTWM2OD17OUiuOVEhdk1? M3jkN3NCVkeHUh?=
EKVX Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzCXnBOUUN3ME2xMlAyOjlizszN M2HmPXNCVkeHUh?=
SW1710 M1Hpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPqSXFKSzVyPUGuNFQzOzNizszN NHn6[W1USU6JRWK=
WM-115 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFwME[2OVYh|ryP NIfQUFBUSU6JRWK=
CAL-54 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwMEewPFEh|ryP M2LuOHNCVkeHUh?=
TGBC24TKB MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfmVXZKSzVyPUGuNFgxPDVizszN NHjweFNUSU6JRWK=
NCI-H520 NYTNd5psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTFwMEi5Olch|ryP MnnHV2FPT0WU
D-423MG NFjt[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF74[5RKSzVyPUGuNFk6PjJizszN M3;sOHNCVkeHUh?=
BFTC-905 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULjeFFPUUN3ME2xMlE{PDR7IN88US=> NILubFFUSU6JRWK=
HT MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwMUO0O|gh|ryP MmjQV2FPT0WU
CTB-1 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfmTHNKSzVyPUGuNVQzQTNizszN NWPWWWJCW0GQR1XS
Hs-578-T NFXwTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjYO21KSzVyPUGuNVk2PjVizszN Mnz3V2FPT0WU
HuH-7 M2\yV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XH[2lEPTB;MT6yNFk1QSEQvF2= NGfxSoxUSU6JRWK=
LB996-RCC NHTrUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTBUHB3UUN3ME2xMlIzOTd5IN88US=> NELWdHJUSU6JRWK=
KYSE-270 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[4fWlEPTB;MT6yPVc{PCEQvF2= MWfTRW5ITVJ?
A4-Fuk MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULBVllSUUN3ME2xMlI6QTl|IN88US=> MYHTRW5ITVJ?
A498 M{LV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnZfHBxUUN3ME2xMlMxPDd2IN88US=> NH3BS4pUSU6JRWK=
SK-MEL-1 NXzKTGxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDGfZRKSzVyPUGuN|A3PzlizszN MXHTRW5ITVJ?
AU565 NVLEWVlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXVTWM2OD1zLkOxPFY{KM7:TR?= MVzTRW5ITVJ?
Saos-2 NXyzeI57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf3Z|JtUUN3ME2xMlM{OjB3IN88US=> M1HkfXNCVkeHUh?=
A549 NGjMSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;STWM2OD1zLkO5PVch|ryP MoTQV2FPT0WU
BFTC-909 NIDyV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNEOzNFUh|ryP MnTQV2FPT0WU
MDA-MB-415 M4HybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f3SmlEPTB;MT60PFY6OiEQvF2= NEDU[nVUSU6JRWK=
639-V MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT5TWM2OD1zLkWwNlQ2KM7:TR?= M2e4TXNCVkeHUh?=
A704 NF;oVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHwVnVVUUN3ME2xMlUxPzh3IN88US=> MWLTRW5ITVJ?
PANC-03-27 NHrBdW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHZVo1KSzVyPUGuOVE1ODhizszN MYPTRW5ITVJ?
SK-MEL-28 M4\lbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnLTWM2OD1zLkW2NFg2KM7:TR?= MUnTRW5ITVJ?
Ramos-2G6-4C10 MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjsW|RwUUN3ME2xMlYxPzR4IN88US=> MoPWV2FPT0WU
HuP-T4 M2[4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED5XWlKSzVyPUGuOlA4PzhizszN NWrxZoVXW0GQR1XS
VA-ES-BJ NX\EV|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwNkGyO{DPxE1? NULJN3gzW0GQR1XS
EFM-19 NH:3TpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[zO5Z3UUN3ME2xMlYyQDFizszN MX\TRW5ITVJ?
G-401 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Lx[2lEPTB;MT62NlE3PCEQvF2= MWLTRW5ITVJ?
D-566MG NUi1TYJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NICySVJKSzVyPUGuOlI2OyEQvF2= M3XsdXNCVkeHUh?=
JVM-3 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFwNkS4O|Uh|ryP NETEZ|NUSU6JRWK=
TK10 MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXrTWM2OD1zLk[3NFg{KM7:TR?= MX7TRW5ITVJ?
BT-20 M4nUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvrcnhKUUN3ME2xMlY5QTB{IN88US=> MmWwV2FPT0WU
EGI-1 NGTTNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPFZoVTUUN3ME2xMlg1PzBzIN88US=> NFXLcXpUSU6JRWK=
EW-16 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTnNGZKSzVyPUGuPFUyQDJizszN MlrRV2FPT0WU
NCI-H2228 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjDRZFnUUN3ME2xMlg2OjB|IN88US=> M{LKT3NCVkeHUh?=
BB49-HNC MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\4dJRKSzVyPUGuPFg3QTJizszN MULTRW5ITVJ?
G-402 MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3LTWM2OD1zLki5O|k4KM7:TR?= NFfYdJFUSU6JRWK=
NCI-H526 NEjhVZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q4UmlEPTB;MT65NVM6KM7:TR?= NYHKR2JNW0GQR1XS
ME-180 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTTU2JKSzVyPUGuPVM1PzdizszN M{XFWHNCVkeHUh?=
PFSK-1 M1mxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwOUS0OVgh|ryP MnPDV2FPT0WU
TYK-nu NEDnZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPoenBKSzVyPUGuPVU5OjNizszN MV3TRW5ITVJ?
HOS NGP4VJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTv[JhqUUN3ME2xMlk4QTR6IN88US=> MkT1V2FPT0WU
T98G MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV76c|NtUUN3ME2xMlk6ODB4IN88US=> NYnXNIxIW0GQR1XS
SK-MES-1 MkfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPkUGttUUN3ME2yMlAyOzN{IN88US=> NWmwVmZ3W0GQR1XS
SNB75 NYXpNYJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPuTWM2OD1{LkCxOVQyKM7:TR?= M4HRenNCVkeHUh?=
LAMA-84 M4Lvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37KS2lEPTB;Mj6wNlY5QSEQvF2= M1LmSHNCVkeHUh?=
CAL-39 NFTYWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwMEOyPEDPxE1? NHfBeWdUSU6JRWK=
LOXIMVI MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvlR2ZKSzVyPUKuNFQxQDRizszN MnW1V2FPT0WU
NH-12 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwMEW0NlQh|ryP M3;W[XNCVkeHUh?=
NCI-H1048 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnoUndxUUN3ME2yMlExPTJizszN MmDjV2FPT0WU
KS-1 NWfPVG56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7ne|VKSzVyPUKuNVExODFizszN MnjXV2FPT0WU
NCI-N87 NYrXVoVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJwMUOzPFQh|ryP NEDaOFBUSU6JRWK=
CHP-212 M3;GcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwMUi0OFIh|ryP NFXnUpBUSU6JRWK=
HCC1419 NXnabJdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDrTWM2OD1{LkKxNVE2KM7:TR?= MU\TRW5ITVJ?
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NCI-H441 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M176bWlEPTB;MkWuO|Q3PSEQvF2= M4TiTHNCVkeHUh?=
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CAL-85-1 M4Pn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm4dWlKSzVyPUK3MlIyOThizszN M{DBcHNCVkeHUh?=
CAL-120 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTVNnZNUUN3ME2yO{43QTF2IN88US=> MWLTRW5ITVJ?
NCI-H2452 NX\0NYlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrLbJRKSzVyPUK3Mlc4OTZizszN MVzTRW5ITVJ?
NCI-H1395 NH[ySJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvIepFCUUN3ME2yO{44QDN|IN88US=> MoHSV2FPT0WU
KYSE-450 M1Xi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTJTWM2OD1{Nz65PFYzKM7:TR?= MUfTRW5ITVJ?
S-117 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXoOllKSzVyPUK5MlM5PTdizszN M4n5XXNCVkeHUh?=
SW13 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofQTWM2OD1{OT64OVE6KM7:TR?= NX\XcZNDW0GQR1XS
ES3 NID0Rm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX63UoxIUUN3ME2zNE4{PzN|IN88US=> NUjVW2hSW0GQR1XS
HCT-116 NF7afXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PTXWlEPTB;M{CuOVU2PCEQvF2= MWLTRW5ITVJ?
NCI-H1693 NYfhbFhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[5UFROUUN3ME2zNE42QTR{IN88US=> MkLzV2FPT0WU
VM-CUB-1 NV3jc3dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnHPWxKSzVyPUOwMlY1OTNizszN NES2NXhUSU6JRWK=
NCI-H2170 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNzLkW3PFQh|ryP MnfjV2FPT0WU
ALL-PO M3LIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjtTWM2OD1|MT64OFI5KM7:TR?= MofiV2FPT0WU
NCI-H661 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P1UGlEPTB;M{KuNFYzOyEQvF2= NUfNbI0xW0GQR1XS
NCI-H2347 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN{LkS4N|ch|ryP MWXTRW5ITVJ?
FTC-133 NXGxXXE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M330R2lEPTB;M{KuO|A3KM7:TR?= M{K1c3NCVkeHUh?=
COLO-829 M{nuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN|LkO0Olch|ryP NVG4NYlrW0GQR1XS
GOTO MmrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTN|LkWyOVgh|ryP NIfHeXpUSU6JRWK=
YAPC MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTN|LkixOVkh|ryP MVXTRW5ITVJ?
LCLC-103H NWrZSHdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvW[GZKSzVyPUO0MlE3OjRizszN NX3lfpBPW0GQR1XS
SiHa MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;ETZNsUUN3ME2zOE4{QDF5IN88US=> NVXocXJmW0GQR1XS
LK-2 M4f0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjBSZVKSzVyPUO0MlU4ODhizszN NH2zVoNUSU6JRWK=
KP-N-YS NFHOOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTN2LkeyNFIh|ryP MoLQV2FPT0WU
NCI-SNU-1 Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDhUYo4UUN3ME2zOU4yPzlizszN MofWV2FPT0WU
KNS-81-FD M2fnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XwNmlEPTB;M{WuOlY{KM7:TR?= M{HM[XNCVkeHUh?=
SCC-9 NHf6cI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m3N2lEPTB;M{[uO|E1PiEQvF2= MVfTRW5ITVJ?
SH-4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnlPVhKSzVyPUO2Mlc{KM7:TR?= M1vBeHNCVkeHUh?=
HCC-1954 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfoUYJKSzVyPUO3MlI4OjlizszN M4qzPHNCVkeHUh?=
BALL-1 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN5LkWzNVYh|ryP NGjnfoZUSU6JRWK=
BE-13 M{DkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzCTYNKSzVyPUO3MlcxOThizszN NXjZOGpOW0GQR1XS
COLO-678 NF\IS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe4WJNKSzVyPUO3Mlk1OzdizszN M1S0UnNCVkeHUh?=
SK-MEL-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaTWM2OD1|OD6yN|k4KM7:TR?= M4XWO3NCVkeHUh?=
OAW-28 NHvvZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN6Lk[zPUDPxE1? MVjTRW5ITVJ?
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A3-KAW NXTqeYhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnXdVdtUUN3ME20NE4{PjZzIN88US=> NVnRdlFzW0GQR1XS
SK-MEL-24 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TtUWlEPTB;NECuOVk{OSEQvF2= MXjTRW5ITVJ?
KYSE-140 M4D4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPEcYNLUUN3ME20NE44OTZ3IN88US=> NWfYOnBRW0GQR1XS
MOLT-16 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj4PFluUUN3ME20NU4yPTN4IN88US=> MnnyV2FPT0WU
CFPAC-1 NFXjPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLFTWM2OD12Mj61NlEyKM7:TR?= M13tN3NCVkeHUh?=
NB14 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTR{LkewNlch|ryP NVL5PVRHW0GQR1XS
COLO-792 M322S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTR{Lki5OlEh|ryP MWXTRW5ITVJ?
RH-1 NEHQ[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfD[mRTUUN3ME20N{41QDN4IN88US=> NHXieZNUSU6JRWK=
NCI-H522 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hq[GlEPTB;NESuN|U3QCEQvF2= NXTjWlQ5W0GQR1XS
Ca-Ski NWjNSpdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mne4TWM2OD12ND64NVE1KM7:TR?= Mo\EV2FPT0WU
KGN M3HxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn1TWM2OD12OD6zNFY{KM7:TR?= MXXTRW5ITVJ?
UACC-62 M4TzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzQNohKSzVyPUS4MlQxPzJizszN MlW3V2FPT0WU
NCI-H358 NHK3RplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PvR2lEPTB;NEmuN|AyQCEQvF2= M2fLZnNCVkeHUh?=
LS-411N MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG5TWM2OD12OT6zNVE5KM7:TR?= MX3TRW5ITVJ?
IST-MES1 M4fhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3mVoJKSzVyPUS5MlU3OjVizszN MYPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

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Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

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  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321
Smiles C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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    Volume
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID