Pictilisib (GDC-0941)

For research use only.

Catalog No.S1065 Synonyms: RG7321

307 publications

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.

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Selleck's Pictilisib (GDC-0941) has been cited by 307 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 Mnu3T4lv[XOnIFHzd4F6 MnSyNUBp NFiwUFNFVVOR NHXxW41KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= NH\Ob3YyQDd3NE[1OC=>
Sf9 M1;VTmtqdmG|ZTDBd5NigQ>? NF7tTWwyKGh? M1r5cmROW09? MnLyTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGgyODR5LWKgcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> MVyxPFc2PDZ3NB?=
Sf9 MmnJT4lv[XOnIFHzd4F6 M{XoOlEhcA>? Mnf0SG1UVw>? M1LEN2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> NYPFN3FWOTh5NUS2OVQ>
Sf9 MWPLbY5ie2ViQYPzZZk> MU[xJIg> NUS4NWJITE2VTx?= MnvBTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? M2TaPFE5PzV2NkW0
Sf9 NWfIeYtMU2mwYYPlJGF{e2G7 NIXHVoEyKGh? Mlq0SG1UVw>? MlLQTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCjbIDoZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZS=> NV\oUHZsOTh5NUS2OVQ>
MDA-MB-361 MYrGeY5kfGmxbjDBd5NigQ>? MlfJNkBp MX3EUXNQ NVfmUXBNUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO Mn;ZNVg4PTR4NUS=
PC3 NYDYPHVjTnWwY4Tpc44hSXO|YYm= MlexNkBp MXvEUXNQ NEDuNGNKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? NXjo[4RGOTh5NUS2OVQ>
U87MG Mo\SSpVv[3Srb36gRZN{[Xl? NVO1[mk3OiCq MUfEUXNQ NInN[WRKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP NYX3[WlCOTh5NUS2OVQ>
MDA-MB-361 NXL6b5B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3MOXI6PiCq M4\UbGROW09? MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= M3mzelE5PzV2NkW0
A2780 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nhNVk3KGh? NYjCU3g5TE2VTx?= MoLPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDMke4NEBk\WyuczD3bZRpKFCLS{PDRUBidmRiUGTFUkBufXSjdHnvckB4cXSqIFnDOVAhd2ZiMD6xOEDPxE1? NWHFbFVUOTh5NUS2OVQ>
PC3 M1XiVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW0W|I6PiCq NXnUR2pITE2VTx?= MUDJR|UxRTBwMkig{txO MnvMNVg4PTR4NUS=
U87MG NYLic3BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYW5OkBp M4W2UWROW09? M4jiNGlEPTB;MD65OUDPxE1? M4fGdlE5PzV2NkW0
Sf9 MkPQT4lv[XOnIFHzd4F6 NEHqbXg{OCCvaX6= MVrEUXNQ NVzuXml7UW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIFud3WwdDDv[kBCXFBiY3;ud5Vu\WRid3n0bEBKSzVyIH;mJFAvODR{IN88US=> MWqyNlU1QDN2Mh?=
RAW 264.7 NWS3[oFMU2mwYYPlJGF{e2G7 Ml7XPVAhdWmw NHfmVoFFVVOR NFf2elZKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> NGDxW2QzOjV2OEO0Ni=>
Sf9 M1\5OmtqdmG|ZTDBd5NigQ>? MYWxJIg> NFXFNlZKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NIjDN|gzOzV2ME[0OS=>
Sf9 MnnWT4lv[XOnIFHzd4F6 MlqxNUBp MVrJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm MmGxNlM2PDB4NEW=
Sf9 M2XNU2tqdmG|ZTDBd5NigQ>? NEDSNXgyKGh? Mln6TY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= MVuyN|U1ODZ2NR?=
Sf9 M3r1RmtqdmG|ZTDBd5NigQ>? Mn7iNUBp NHGyO2RKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk M1fRZlI{PTRyNkS1
SKOV3 MmDDT4lv[XOnIFHzd4F6 MknONUDPxE1? NFrhOGUyKGh? MYXEUXNQ MX7Jcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9v MUKyN|M3ODN2OB?=
MCF7 M4fTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfRNUDPxE1? NG\FOoY6PiCq MXnEUXNQ MlPiS2k2OD1yLkC3NFIh|ryP M13K[|I{OzZyM{S4
SKOV3 M{DYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3mWIcxOSEQvF2= M4foVlk3KGh? NHTydXFFVVOR NFLuXI5IUTVyPUCuNVQ4PiEQvF2= MVeyN|M3ODN2OB?=
PC3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq1[3k4OiCq NHjZT5BFVVOR NWXGdWZ{UUN3ME2wMlI5KM7:TR?= MXKyNVk5OTdzNB?=
MCF7.1 NWHXUmRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDNbpB7PzJiaB?= Mmj2SG1UVw>? MnPQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP NUXTbXhIOjF7OEG3NVQ>
MCF7-neo/Her2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fDU|czKGh? NXT2[ZY6TE2VTx?= Ml[xTWM2OD1yLkK5JO69VQ>? NFrudpQzOzZ4MkmwNy=>
MCF7-neo/Her2 M3LJPGtqdmG|ZTDBd5NigQ>? NETieZhKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjDheEBUPDd|IIfpeIghUUN3MDDv[kAxNjByNzFOwG0> NF;vcWczOzZ4MkmwNy=>
PC3 NHK5eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPEXFR6PzJiaB?= MXnEUXNQ Mm\zSWM2OD1yLkO0JO69VQ>? M4S0SlIyQTh3NkO5
MCF7.1 M2DOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnXZWk4OiCq NGDtU2VFVVOR NIDXWXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDFR|UxKG:oIECuN|kh|ryP Mn\4NlE6QDV4M{m=
PC3 M1rYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYq3NkBp NHW3NI1FVVOR Mn\NRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN MnKyNlAxPTB4Nkm=
MCF7.1 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rwW|czKGh? MWLEUXNQ MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO M4jHblIxODVyNk[5
MCF7.1 NVi3b|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXy3NkBp M4PPOWVEPTB;MD63NkDPxE1? NH3qeXUzODN2Nk[1Oi=>
NCI-H1975 MnHDR5l1d3SxeHnjJGF{e2G7 NHP6UVE4OiCq MkfvTWM2OD1yLkK3JO69VQ>? M{DJVFI{ODV7NUS1
H460 Moq3R5l1d3SxeHnjJGF{e2G7 MVK3NkBp NIHiXHFKSzVyPUCuPFch|ryP NIfyOHMzOzB3OUW0OS=>
HT-29 NIjnR3dEgXSxdH;4bYMhSXO|YYm= NY[4SVN{PzJiaB?= NUfndmY4UUN3ME2wMlY3KM7:TR?= MY[yN|A2QTV2NR?=
HepG2 NHHn[I5EgXSxdH;4bYMhSXO|YYm= NH;ZcWg4OiCq M1nlemlEPTB;MTFOwG0> MY[yN|A2QTV2NR?=
SGC7901 NInlUYNEgXSxdH;4bYMhSXO|YYm= MU[3NkBp M2G0SWlEPTB;MT64JO69VQ>? Ml;QNlMxPTl3NEW=
NCI-H226 M{L1OGN6fG:2b4jpZ{BCe3OjeR?= NIH2bVA4OiCq M2Xk[mlEPTB;Mj65JO69VQ>? MUCyN|A2QTV2NR?=
A549 MYLDfZRwfG:6aXOgRZN{[Xl? MX:3NkBp MWnJR|UxRTZwOTFOwG0> MVuyN|A2QTV2NR?=
U87MG NF35WVBEgXSxdH;4bYMhSXO|YYm= MXm3NkBp MXXJR|UxRTdwN{eg{txO M3;kS|I{ODV7NUS1
HBC4 NFzNOlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjKcI9oT0l3ME2tOk4xOyCP NEiwW3EzOjN|NkK0Oi=>
BSY1 M{fI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHu2RY5td2eJSUWwQU03NjlyIF2= NInqWnozOjN|NkK0Oi=>
HBC5 M2\2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i2Ooxw\0eLNUC9MVYvPjBiTR?= MVeyNlM{PjJ2Nh?=
MCF7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnyflltd2eJSUWwQU04NjN|IF2= MU[yNlM{PjJ2Nh?=
MDA-MB-231 NGT1Nm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nPd4xw\0eLNUC9MVUvPDZiTR?= NVuxOIRWOjJ|M{[yOFY>
U251 NI\mUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;acI9oT0l3ME2tOU42OCCP MnjuNlI{OzZ{NE[=
SF268 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf2Omttd2eJSUWwQU02NjN7IF2= M2TjOFIzOzN4MkS2
SF295 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXKyO4I6dG:pR1m1NF0uPi5|NzDN NXvO[HcxOjJ|M{[yOFY>
SF539 NXjN[3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfxWFR{dG:pR1m1NF0uPi53MDDN MlXXNlI{OzZ{NE[=
SNB75 NWXhRolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnsc4dIUTVyPT23MlExKE1? MlfTNlI{OzZ{NE[=
SNB78 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrsc4dIUTVyPT22MlUzKE1? MXmyNlM{PjJ2Nh?=
HCC2998 NXz0OFBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\rcI9oT0l3ME2tOk4zQSCP NYHoNHhjOjJ|M{[yOFY>
KM12 NV33VJhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD2[3Ftd2eJSUWwQU02Njd4IF2= MkTGNlI{OzZ{NE[=
HT-29 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn3bWZZdG:pR1m1NF0uPi5|MDDN MUGyNlM{PjJ2Nh?=
HCT15 NWTsPVI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[1WZRNdG:pR1m1NF0uPi5zMjDN MkLTNlI{OzZ{NE[=
HCT116 M3HE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m2Toxw\0eLNUC9MVUvQDdiTR?= Moj3NlI{OzZ{NE[=
NCI-H23 NWnUT5BuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfyVoxpdG:pR1m1NF0uPS55MzDN NUDDZ|ZbOjJ|M{[yOFY>
NCI-H226 NIrMcI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn5PZBtd2eJSUWwQU03NjJzIF2= M3T0V|IzOzN4MkS2
NCI-H522 M1jpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS4cI9oT0l3ME2tOk42QCCP MnfGNlI{OzZ{NE[=
NCI-H483 NFXLNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLIcI9oT0l3ME2tOk42PiCP NFrtR3ozOjN|NkK0Oi=>
A549 NW\4eVRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL2V2xtd2eJSUWwQU03NjF3IF2= M{DxdFIzOzN4MkS2
DMS273 NYSzcWlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LSXYxw\0eLNUC9MVYvPDNiTR?= M1;YclIzOzN4MkS2
DMS114 M3TnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknmcI9oT0l3ME2tOU46OiCP MXeyNlM{PjJ2Nh?=
LOXIMVI M{G0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Ib4xw\0eLNUC9MVYvOjliTR?= NXfhfY1JOjJ|M{[yOFY>
OVCAR3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHsc4dIUTVyPT22MlcyKE1? MWWyNlM{PjJ2Nh?=
OVCAR4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvRS3Ntd2eJSUWwQU02Njd4IF2= NV\OT|RVOjJ|M{[yOFY>
OVCAR5 M{DFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TJeYxw\0eLNUC9MVYvOjZiTR?= NFjZ[G4zOjN|NkK0Oi=>
OVCAR8 NVTJWI51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDGcI9oT0l3ME2tOU44OyCP MV:yNlM{PjJ2Nh?=
SKOV3 M1TiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PKc4xw\0eLNUC9MVYvPTJiTR?= NXzrPFBkOjJ|M{[yOFY>
RXF631L M1H6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXYVYttd2eJSUWwQU03Njh6IF2= MlXMNlI{OzZ{NE[=
ACHN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\sc4dIUTVyPT22MlA4KE1? NIjW[G0zOjN|NkK0Oi=>
St-4 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT5cI9oT0l3ME2tOU42PiCP MV2yNlM{PjJ2Nh?=
MKN1 NFy3bYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfocI9oT0l3ME2tO{4xQCCP MmWxNlI{OzZ{NE[=
MKN7 NGnMV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\2NJI5dG:pR1m1NF0uPi53MDDN M2fHcFIzOzN4MkS2
MKN28 MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXsc4dIUTVyPT21MlUzKE1? M{jrO|IzOzN4MkS2
MKN45 M3TZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3sc4dIUTVyPT22MlU2KE1? NI\UU48zOjN|NkK0Oi=>
MKN74 NH60SZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiz[YRQdG:pR1m1NF0uPi5yMjDN MmmzNlI{OzZ{NE[=
DU145 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXLcI9oT0l3ME2tOU45PSCP NF\DPGYzOjN|NkK0Oi=>
PC3 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\pTWdtd2eJSUWwQU03NjZ4IF2= MYeyNlM{PjJ2Nh?=
ES5 M4HPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTVyLkKxJI5O Mlz5V2FPT0WU
HH M3TrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M332WmlEPTB;MUGxMlA5KG6P NXnXd41xW0GQR1XS
MHH-PREB-1 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETlW|ZKSzVyPUGxOE4{KG6P MYHTRW5ITVJ?
NCI-H1770 M3HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF{Mz64OkBvVQ>? MlXqV2FPT0WU
HuO9 NGTqco5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJyNj6wNkBvVQ>? NGrMcWpUSU6JRWK=
HAL-01 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne4TWM2OD1{ME[uO|Mhdk1? NGGxW2RUSU6JRWK=
NOS-1 NVj5T5NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j5fWlEPTB;MkGxMlgzKG6P M3zZVHNCVkeHUh?=
HGC-27 M37CVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLKTWM2OD1{MUKuOVchdk1? MlLvV2FPT0WU
NB69 M4j2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zoWmlEPTB;MkS1MlI4KG6P NEnCOXdUSU6JRWK=
RS4-11 NUHyWHgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrVTWM2OD1{NkGuO|Yhdk1? MYDTRW5ITVJ?
DOK NXW0VFM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDQTWM2OD1|MEGuO{BvVQ>? NYXz[4x1W0GQR1XS
LB2241-RCC NG\mdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn36TWM2OD1|MEOuPFQhdk1? NX;TXXB7W0GQR1XS
NCI-H1623 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDUTWM2OD1|MESuNFghdk1? M3T6dnNCVkeHUh?=
YH-13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTNyND6zNkBvVQ>? M3[4UXNCVkeHUh?=
BPH-1 NEPVVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnkU5hKSzVyPUOxOEBvVQ>? MYPTRW5ITVJ?
AN3-CA Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TTWWlEPTB;M{SwMlM4KG6P NXj0UYFLW0GQR1XS
ES7 M2TCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT2TWM2OD1|NEGuPVkhdk1? MkHjV2FPT0WU
MDA-MB-175-VII MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jIZmlEPTB;M{WyMlkzKG6P NXW1RpRYW0GQR1XS
GAMG NHj6TJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvTTWM2OD1|N{CuPFUhdk1? NUDoOIFzW0GQR1XS
CHL-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN5OD62OUBvVQ>? NVfyfGpkW0GQR1XS
NB7 Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXhTWM2OD1|OEmuPFMhdk1? NHPDTZBUSU6JRWK=
MFE-280 M3fVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonuTWM2OD12MUiuNkBvVQ>? NELpbWJUSU6JRWK=
HL-60 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR{NT63OUBvVQ>? M1zjfHNCVkeHUh?=
GCIY NYD3SpNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG3XplKSzVyPUSzN{45KG6P MVjTRW5ITVJ?
MDA-MB-361 M2D6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrKXlhiUUN3ME20N|kvOTNibl2= NFrTXWNUSU6JRWK=
LXF-289 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TJVmlEPTB;NES4MlI4KG6P M1nJWHNCVkeHUh?=
NBsusSR NV3COIlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrHUmtqUUN3ME20PFgvQDVibl2= NWDJXIRXW0GQR1XS
KU-19-19 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17a[GlEPTB;NUG2MlA4KG6P Mm\pV2FPT0WU
A204 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf0TWM2OD13MkKuN|Mhdk1? M{PJfHNCVkeHUh?=
LB1047-RCC NIP1TlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvHbG57UUN3ME21NlIvQTNibl2= M2DIdHNCVkeHUh?=
COLO-684 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TTbmlEPTB;NUKzMlEyKG6P NGnk[YJUSU6JRWK=
PA-1 NGjFNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXLV|lDUUN3ME21N|IvPDFibl2= NESydI5USU6JRWK=
MG-63 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKyNWE2UUN3ME21OFEvOTFibl2= Mn3EV2FPT0WU
BHT-101 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7IXopKSzVyPUW0OE46PCCwTR?= MV\TRW5ITVJ?
NKM-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrIVpBKSzVyPUW5N{4xQSCwTR?= NF\uUGlUSU6JRWK=
T47D NVrQZoVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTV7Nz61OkBvVQ>? NG\p[GNUSU6JRWK=
MOLT-4 M2LVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTZ{Mz62NkBvVQ>? M3LKd3NCVkeHUh?=
IGROV-1 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnr[G1mUUN3ME22N|QvOzFibl2= NHS4WXVUSU6JRWK=
ES4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTZ|OT61OEBvVQ>? NICwUI5USU6JRWK=
HuO-3N1 M4HGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XBXmlEPTB;NkSyMlM5KG6P NVfRcplJW0GQR1XS
NEC8 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn0UVRKSzVyPU[1N{42PyCwTR?= MYTTRW5ITVJ?
HO-1-N-1 M{DkPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7nfnA6UUN3ME22OVkvOTdibl2= MYXTRW5ITVJ?
EPCL-272H NVzqT|RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofzTWM2OD14OEeuNlEhdk1? MX;TRW5ITVJ?
D-263MG NX;iS|N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7hPZRKSzVyPUexPE4yKG6P MWnTRW5ITVJ?
MV-4-11 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTd{ND6zNUBvVQ>? MVzTRW5ITVJ?
SK-NEP-1 NEDLbotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTYTWM2OD15MkWuPVQhdk1? NH3vS3dUSU6JRWK=
SW872 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjKVYxKSzVyPUeyO{45QSCwTR?= NUTxV3I3W0GQR1XS
P30-OHK NFnucm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnJbHVqUUN3ME23N|AvPzFibl2= M{LrN3NCVkeHUh?=
OMC-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTd3MT6wPUBvVQ>? MnzOV2FPT0WU
LoVo NXe0cVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jaW2lEPTB;N{e3Mlkhdk1? NEHNcWJUSU6JRWK=
LNCaP-Clone-FGC NH25[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljMTWM2OD15OU[uN|Qhdk1? MofzV2FPT0WU
L-363 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXrVHdZUUN3ME23PVgvPDJibl2= MoDZV2FPT0WU
ES8 M2Ttfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq5SHJKSzVyPUixNE42OiCwTR?= NID2RYNUSU6JRWK=
697 NVHWcoRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor4TWM2OD16M{GuOVUhdk1? NELIbWRUSU6JRWK=
HSC-3 Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn3ZYxKSzVyPUizPU42PCCwTR?= MmDlV2FPT0WU
H4 M3HuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe0TGZoUUN3ME24OVAvQDVibl2= NFW5XI1USU6JRWK=
QIMR-WIL NYHyclRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLvRoNQUUN3ME24OlUvOiCwTR?= NUfNXG1nW0GQR1XS
OAW-42 MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTh5Mj6xPUBvVQ>? MXHTRW5ITVJ?
MCF7 NXXJS4JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHtb2tiUUN3ME24PVgvPTlibl2= NG[1WXBUSU6JRWK=
SCC-25 NGCzUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLTWM2OD17MUSuNVkhdk1? M1;TVHNCVkeHUh?=
NCI-H1563 M{nuV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTlzNT65PUBvVQ>? M{fHWXNCVkeHUh?=
OVCAR-5 NVy0cnF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTl2MD6xO{BvVQ>? NXT4b|NkW0GQR1XS
HDLM-2 NXnWdFZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli0TWM2OD17NEmuNkBvVQ>? NITaPJlUSU6JRWK=
NB5 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTl3Nj62JI5O NVLkbHE2W0GQR1XS
NCI-H292 NG\uUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\XR2lEPTB;OUe0MlMzKG6P Mm\yV2FPT0WU
A101D NXnRWYZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTl7MD6xPUBvVQ>? NIrNb4dUSU6JRWK=
NCI-H1648 M3rSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m3eGlEPTB;OUm4MlUyKG6P NGTJbIVUSU6JRWK=
EKVX MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnkTWM2OD1zLkCxNlkh|ryP NEL5OlNUSU6JRWK=
SW1710 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwMESyN|Mh|ryP MlP0V2FPT0WU
WM-115 M2jxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfCSWt6UUN3ME2xMlA3PjV4IN88US=> NVjQXJl6W0GQR1XS
CAL-54 NH71[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e2RWlEPTB;MT6wO|A5OSEQvF2= MYLTRW5ITVJ?
TGBC24TKB NX71XlRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMEiwOFUh|ryP MXfTRW5ITVJ?
NCI-H520 NWHDe285T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fV[WlEPTB;MT6wPFk3PyEQvF2= M33PbHNCVkeHUh?=
D-423MG MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvxWG1tUUN3ME2xMlA6QTZ{IN88US=> M{LGVnNCVkeHUh?=
BFTC-905 NI\CcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwMUO0OFkh|ryP NHjJTG5USU6JRWK=
HT MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HMWmlEPTB;MT6xN|Q4QCEQvF2= NGDve29USU6JRWK=
CTB-1 NGLmOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfRSYprUUN3ME2xMlE1Ojl|IN88US=> NXPZVmd6W0GQR1XS
Hs-578-T NXi1NVVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\P[odKSzVyPUGuNVk2PjVizszN MoWzV2FPT0WU
HuH-7 M{\V[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3MOlZKSzVyPUGuNlA6PDlizszN NWCxV2lbW0GQR1XS
LB996-RCC NX;0eItrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFwMkKxO|ch|ryP NFrhe2xUSU6JRWK=
KYSE-270 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnvTWM2OD1zLkK5O|M1KM7:TR?= M{[zTXNCVkeHUh?=
A4-Fuk NVm2SFRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLITWM2OD1zLkK5PVk{KM7:TR?= NET3VotUSU6JRWK=
A498 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml32TWM2OD1zLkOwOFc1KM7:TR?= NVu3d2FHW0GQR1XS
SK-MEL-1 M2KwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LsN2lEPTB;MT6zNFY4QSEQvF2= NXHZVJF4W0GQR1XS
AU565 M2XR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwM{G4OlMh|ryP NGr1NnNUSU6JRWK=
Saos-2 NYPlT5B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTFwM{OyNFUh|ryP Mn\pV2FPT0WU
A549 NEH5bIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1zLkO5PVch|ryP NYPNRZlJW0GQR1XS
BFTC-909 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\xV2lEPTB;MT60N|MxPSEQvF2= NGnocYdUSU6JRWK=
MDA-MB-415 M3Pu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvhO|hKSzVyPUGuOFg3QTJizszN NWriUYlFW0GQR1XS
639-V MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX1TWM2OD1zLkWwNlQ2KM7:TR?= NFm1ZnVUSU6JRWK=
A704 NV;tZodIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXjTWM2OD1zLkWwO|g2KM7:TR?= NXfjN5pyW0GQR1XS
PANC-03-27 NIPpZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFwNUG0NFgh|ryP NX\vb5ZuW0GQR1XS
SK-MEL-28 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrQO3d2UUN3ME2xMlU3ODh3IN88US=> NFPJeGZUSU6JRWK=
Ramos-2G6-4C10 NYjEcoVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjnRpJKSzVyPUGuOlA4PDZizszN NIPyfVFUSU6JRWK=
HuP-T4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonWTWM2OD1zLk[wO|c5KM7:TR?= MnLkV2FPT0WU
VA-ES-BJ NFXGcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHCTWM2OD1zLk[xNlch|ryP M{fRO3NCVkeHUh?=
EFM-19 NVLsXGpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFwNkG4NUDPxE1? MUHTRW5ITVJ?
G-401 NYfVe21yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXBcI5WUUN3ME2xMlYzOTZ2IN88US=> M2mxXnNCVkeHUh?=
D-566MG NV3HV4xbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfaXnVYUUN3ME2xMlYzPTNizszN MV;TRW5ITVJ?
JVM-3 M{LVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTDS2tmUUN3ME2xMlY1QDd3IN88US=> NEDjT5RUSU6JRWK=
TK10 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojnTWM2OD1zLk[3NFg{KM7:TR?= NXfCNlJbW0GQR1XS
BT-20 M4GxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTvTWM2OD1zLk[4PVAzKM7:TR?= NXTmZVZ{W0GQR1XS
EGI-1 NXLncnJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFwOES3NFEh|ryP MUXTRW5ITVJ?
EW-16 NELSc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXLTWM2OD1zLki1NVgzKM7:TR?= NVzF[HN2W0GQR1XS
NCI-H2228 M4jVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjxbo5KSzVyPUGuPFUzODNizszN NYj5RY9MW0GQR1XS
BB49-HNC NYfCZmRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\XTWM2OD1zLki4OlkzKM7:TR?= NVO3eFc{W0GQR1XS
G-402 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3vbW1KSzVyPUGuPFk4QTdizszN MoHUV2FPT0WU
NCI-H526 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7QR21uUUN3ME2xMlkyOzlizszN M1i5UXNCVkeHUh?=
ME-180 NV\1SYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwOUO0O|ch|ryP M{PDVnNCVkeHUh?=
PFSK-1 NHfQ[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwOUS0OVgh|ryP M3nNeHNCVkeHUh?=
TYK-nu MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfVSmlFUUN3ME2xMlk2QDJ|IN88US=> Ml20V2FPT0WU
HOS M4\TcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vjWWlEPTB;MT65O|k1QCEQvF2= MkfHV2FPT0WU
T98G NF;DXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwOUmwNFYh|ryP NIDrflhUSU6JRWK=
SK-MES-1 M{[wPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn36TWM2OD1{LkCxN|MzKM7:TR?= NXnaXFRDW0GQR1XS
SNB75 MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPvPG1KSzVyPUKuNFE2PDFizszN MoOzV2FPT0WU
LAMA-84 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v6XWlEPTB;Mj6wNlY5QSEQvF2= NX;oU3JbW0GQR1XS
CAL-39 NXLmOpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljqTWM2OD1{LkCzNlgh|ryP MVPTRW5ITVJ?
LOXIMVI NGnrUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\NTWM2OD1{LkC0NFg1KM7:TR?= M1Tq[3NCVkeHUh?=
NH-12 M1H6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTLTWM2OD1{LkC1OFI1KM7:TR?= M4LNWnNCVkeHUh?=
NCI-H1048 NVW0bo1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:zUlA2UUN3ME2yMlExPTJizszN NVXGZXFFW0GQR1XS
KS-1 MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fYXWlEPTB;Mj6xNVAxOSEQvF2= NFHFVnJUSU6JRWK=
NCI-N87 NWn2N4psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XzSmlEPTB;Mj6xN|M5PCEQvF2= NWPNZYJpW0GQR1XS
CHP-212 NXzuUVE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJwMUi0OFIh|ryP MV7TRW5ITVJ?
HCC1419 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXmTWM2OD1{LkKxNVE2KM7:TR?= NHz6cFRUSU6JRWK=
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LB-831-BLC NGCyfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3iw[mlEPTB;MUOuOlI1PiEQvF2= NVTL[GZLW0GQR1XS
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DB NXPXV45ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD4e4hlUUN3ME2xN{45Ozh2IN88US=> NU\CSmd5W0GQR1XS
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CAL-72 NX:3O5c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUntUJBYUUN3ME2xOE44Pzh|IN88US=> MWHTRW5ITVJ?
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SF268 MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K1SmlEPTB;MU[uOFUzKM7:TR?= M1rtO3NCVkeHUh?=
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HCC1395 MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF6LkW2NVEh|ryP NVPyNIlvW0GQR1XS
NUGC-3 MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr5ZpRNUUN3ME2xPE43PTh2IN88US=> Mlj0V2FPT0WU
BB65-RCC M{nNO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi1OZFKSzVyPUG4MlY3QSEQvF2= M1zuZnNCVkeHUh?=
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NCI-H727 MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoryTWM2OD1zOT6zNlk2KM7:TR?= M4j3S3NCVkeHUh?=
KP-4 NG\nW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXWVFNKSzVyPUG5Mlg2OzFizszN MlXGV2FPT0WU
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GI-ME-N MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\DeWlEPTB;MkCuN|M4OyEQvF2= M1\5NXNCVkeHUh?=
OVCAR-3 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJyLkW4NlIh|ryP NUPBSVAxW0GQR1XS
HD-MY-Z NVHROVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjXWpdNUUN3ME2yNU4{Pjl4IN88US=> MUHTRW5ITVJ?
NTERA-S-cl-D1 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJzLk[3NlIh|ryP MWnTRW5ITVJ?
SCH M3PzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLv[nFKSzVyPUKyMlQ6PiEQvF2= MVjTRW5ITVJ?
KARPAS-299 NXzrRo51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[2Z25LUUN3ME2yN{4{QDh5IN88US=> NX3GW|hjW0GQR1XS
NCI-H1650 MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfNb4RKSzVyPUKzMlkzPDFizszN MmjDV2FPT0WU
ACHN MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorvTWM2OD1{ND60OlU3KM7:TR?= NWqwN4ZxW0GQR1XS
M059J NH:2W|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ2LkW2N|Qh|ryP MnjYV2FPT0WU
AM-38 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HmSWlEPTB;MkWuOFgyKM7:TR?= NYHUWG1CW0GQR1XS
KG-1 M3vMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX2bHRGUUN3ME2yOU42PDl2IN88US=> MXHTRW5ITVJ?
COLO-824 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTNOnRKSzVyPUK1MlU2QTlizszN M4L3U3NCVkeHUh?=
NCI-H1155 NFXUZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32yNWlEPTB;MkWuOVg1PyEQvF2= MUPTRW5ITVJ?
NCI-H441 NYLkXWlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ3Lke0OlUh|ryP MnLaV2FPT0WU
J-RT3-T3-5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHReZFsUUN3ME2yOk4{ODJ5IN88US=> NX3ve5AyW0GQR1XS
JEG-3 NUmxVFR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HSWmlEPTB;Mk[uOlgxPSEQvF2= NHvVdVJUSU6JRWK=
RKO M1vDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ4Lke2N|Ih|ryP MXnTRW5ITVJ?
CAL-85-1 NEXEbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG5XZVTUUN3ME2yO{4zOTF6IN88US=> M17veHNCVkeHUh?=
CAL-120 M1joPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn2[oVyUUN3ME2yO{43QTF2IN88US=> M3nRVXNCVkeHUh?=
NCI-H2452 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vodmlEPTB;MkeuO|cyPiEQvF2= Mn3WV2FPT0WU
NCI-H1395 NU\wSXk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK0TWM2OD1{Nz63PFM{KM7:TR?= NEXXOlZUSU6JRWK=
KYSE-450 NWTDOYpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzVNIlKSzVyPUK3Mlk5PjJizszN MWTTRW5ITVJ?
S-117 NIHrfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJ7LkO4OVch|ryP NXX5OVd4W0GQR1XS
SW13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJ7Lki1NVkh|ryP NInS[2VUSU6JRWK=
ES3 NG[weWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNyLkO3N|Mh|ryP NWLIN5kxW0GQR1XS
HCT-116 NHX3PG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTNyLkW1OVQh|ryP MoLHV2FPT0WU
NCI-H1693 NF:y[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV64PVdWUUN3ME2zNE42QTR{IN88US=> NHHiZ|RUSU6JRWK=
VM-CUB-1 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nkPGlEPTB;M{CuOlQyOyEQvF2= NX7OToZ3W0GQR1XS
NCI-H2170 NXXZZmxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1naZ2lEPTB;M{GuOVc5PCEQvF2= NH7uRllUSU6JRWK=
ALL-PO M2Did2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInqfJJKSzVyPUOxMlg1OjhizszN M{S1SnNCVkeHUh?=
NCI-H661 MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fZVWlEPTB;M{KuNFYzOyEQvF2= MYPTRW5ITVJ?
NCI-H2347 NInkT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PzVGlEPTB;M{KuOFg{PyEQvF2= MYfTRW5ITVJ?
FTC-133 NFHWbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PZdmlEPTB;M{KuO|A3KM7:TR?= NHvoOmJUSU6JRWK=
COLO-829 NIrsSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj2VZdjUUN3ME2zN{4{PDZ5IN88US=> MmK1V2FPT0WU
GOTO MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C2SmlEPTB;M{OuOVI2QCEQvF2= NGjGcWdUSU6JRWK=
YAPC NFywVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHGNo9KSzVyPUOzMlgyPTlizszN MVrTRW5ITVJ?
LCLC-103H M2WyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrDdIxKSzVyPUO0MlE3OjRizszN NXTSbI1RW0GQR1XS
SiHa NIPZNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTN2LkO4NVch|ryP MWTTRW5ITVJ?
LK-2 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LGU2lEPTB;M{SuOVcxQCEQvF2= NHHw[Y9USU6JRWK=
KP-N-YS M3Tke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN2LkeyNFIh|ryP MUnTRW5ITVJ?
NCI-SNU-1 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLGVZVKSzVyPUO1MlE4QSEQvF2= MlzMV2FPT0WU
KNS-81-FD MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLJWo83UUN3ME2zOU43PjNizszN NF2xfXVUSU6JRWK=
SCC-9 M3LZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN4LkexOFYh|ryP MlrPV2FPT0WU
SH-4 NXvNVnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\hTWM2OD1|Nj63N{DPxE1? MXLTRW5ITVJ?
HCC-1954 M4P3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO4bYtKSzVyPUO3MlI4OjlizszN MorHV2FPT0WU
BALL-1 NVnQXmVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr3V4ZKSzVyPUO3MlU{OTZizszN NXzmdHdoW0GQR1XS
BE-13 M3[yfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHwTWM2OD1|Nz63NFE5KM7:TR?= MXPTRW5ITVJ?
COLO-678 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN5Lkm0N|ch|ryP MYHTRW5ITVJ?
SK-MEL-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPQTWM2OD1|OD6yN|k4KM7:TR?= MnPoV2FPT0WU
OAW-28 NYS1bFlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfhfXd7UUN3ME2zPE43OzlizszN NIXr[W5USU6JRWK=
CAMA-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN6Lkm2PVEh|ryP MV\TRW5ITVJ?
C2BBe1 NHPDS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDKTWM2OD1|OT64NVgh|ryP MlL6V2FPT0WU
A3-KAW MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HCWmlEPTB;NECuN|Y3OSEQvF2= MnnVV2FPT0WU
SK-MEL-24 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml35TWM2OD12MD61PVMyKM7:TR?= NFzYV5VUSU6JRWK=
KYSE-140 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Zcm1KSzVyPUSwMlcyPjVizszN MYHTRW5ITVJ?
MOLT-16 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRzLkG1N|Yh|ryP NXnOXXRqW0GQR1XS
CFPAC-1 M1jzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK5O|lGUUN3ME20Nk42OjFzIN88US=> MUjTRW5ITVJ?
NB14 NVvR[2ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7hTWM2OD12Mj63NFI4KM7:TR?= NHzTWVZUSU6JRWK=
COLO-792 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DFOWlEPTB;NEKuPFk3OSEQvF2= NEnJPG5USU6JRWK=
RH-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\seo9KSzVyPUSzMlQ5OzZizszN NXjldpdvW0GQR1XS
NCI-H522 NXjnVWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTR2LkO1Olgh|ryP NG\jZ2VUSU6JRWK=
Ca-Ski MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTR2LkixNVQh|ryP NXW2e|d{W0GQR1XS
KGN NV\4[YVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfYeY5KSzVyPUS4MlMxPjNizszN NWm1XnpZW0GQR1XS
UACC-62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzbIJ1UUN3ME20PE41ODd{IN88US=> Mlj0V2FPT0WU
NCI-H358 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTR7LkOwNVgh|ryP NH;Tdo9USU6JRWK=
LS-411N NH[1T2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfHTWM2OD12OT6zNVE5KM7:TR?= MVjTRW5ITVJ?
IST-MES1 NF7UdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnVW2ZKSzVyPUS5MlU3OjVizszN MVnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

- Collapse

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

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  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321
Smiles CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID