Pictilisib (GDC-0941)

For research use only.

Catalog No.S1065 Synonyms: RG7321

327 publications

Pictilisib (GDC-0941) Chemical Structure

CAS No. 957054-30-7

Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.

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Selleck's Pictilisib (GDC-0941) has been cited by 327 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MlTST4lv[XOnIFHzd4F6 NGGzPWEyKGh? NVzvXlc4TE2VTx?= NWjodXl[UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN MXyxPFc2PDZ3NB?=
Sf9 MkjOT4lv[XOnIFHzd4F6 NVPrb5JNOSCq MXnEUXNQ NUC0ZY5sUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEhzMES3MXIhdXW2YX70JIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? NVTZTFVOOTh5NUS2OVQ>
Sf9 MVfLbY5ie2ViQYPzZZk> M4\oNlEhcA>? M4[1OGROW09? MnrJTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M4f5dVE5PzV2NkW0
Sf9 NHf6UnVMcW6jc3WgRZN{[Xl? NGnDeJoyKGh? NEHycWxFVVOR MmqzTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? NWrCcVZPOTh5NUS2OVQ>
Sf9 NI\DOWpMcW6jc3WgRZN{[Xl? NGDUO|MyKGh? Mnm2SG1UVw>? NGHUc2FKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHHsdIhiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhi NITBZYoyQDd3NE[1OC=>
MDA-MB-361 Mn;VSpVv[3Srb36gRZN{[Xl? MUOyJIg> M4XXN2ROW09? M1n4T2lvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvODJ6IN88US=> MXyxPFc2PDZ3NB?=
PC3 Mn;KSpVv[3Srb36gRZN{[Xl? NXTxZnl4OiCq MWPEUXNQ NF3xT2RKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? M37EXFE5PzV2NkW0
U87MG M4DNRWZ2dmO2aX;uJGF{e2G7 M3W5PFIhcA>? NXL1VHF4TE2VTx?= Mn7GTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iVUi3UWch[2WubIOge4l1cCCLQ{WwJI9nKDBwMES2JO69VQ>? MofQNVg4PTR4NUS=
MDA-MB-361 NWXDWlR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXicIE6PiCq MVnEUXNQ MkLmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE44OiEQvF2= MVexPFc2PDZ3NB?=
A2780 M{jXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT3N5BWQTZiaB?= MlPkSG1UVw>? NHnDeIxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGyO|gxKGOnbHzzJJdqfGhiUFnLN2NCKGGwZDDQWGVPKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlE1KM7:TR?= NWTJUmN3OTh5NUS2OVQ>
PC3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7nR2FXQTZiaB?= NI\KPG9FVVOR MVLJR|UxRTBwMkig{txO M3vBPFE5PzV2NkW0
U87MG NHzueYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLjPVYhcA>? MWLEUXNQ M3nMPGlEPTB;MD65OUDPxE1? M4f3eVE5PzV2NkW0
Sf9 MYnLbY5ie2ViQYPzZZk> M3TzdFMxKG2rbh?= NEm5eFVFVVOR MkD1TY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHHtc5VvfCCxZjDBWHAh[2:wc4Xt[YQhf2m2aDDJR|UxKG:oIECuNFQzKM7:TR?= MVqyNlU1QDN2Mh?=
RAW 264.7 NF;5eHJMcW6jc3WgRZN{[Xl? MWq5NEBucW5? MmXPSG1UVw>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= NEi2SGMzOjV2OEO0Ni=>
Sf9 NFv3XlNMcW6jc3WgRZN{[Xl? M3L2ZVEhcA>? NX7s[oM2UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO NULKfVFTOjN3NEC2OFU>
Sf9 M1LUNmtqdmG|ZTDBd5NigQ>? MlvxNUBp NX\KNVhZUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2SnbIThJIV5eHKnc4Pl[C=> MXiyN|U1ODZ2NR?=
Sf9 M1PLbWtqdmG|ZTDBd5NigQ>? MVSxJIg> NVTxSG5{UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> NXftdI1FOjN3NEC2OFU>
Sf9 NGDlbZNMcW6jc3WgRZN{[Xl? NH73Nm0yKGh? MVrJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZYxxcGFiZYjwdoV{e2Wm NEP2fI8zOzV2ME[0OS=>
SKOV3 M2LTRmtqdmG|ZTDBd5NigQ>? MlvoNUDPxE1? M{nIbFEhcA>? NGnJZZdFVVOR MmCzTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdg>? MkfGNlM{PjB|NEi=
MCF7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3vNUDPxE1? NVXvWYhyQTZiaB?= MXrEUXNQ NGr2XItIUTVyPUCuNFcxOiEQvF2= MlPuNlM{PjB|NEi=
SKOV3 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3cZB1OSEQvF2= M{nlc|k3KGh? NETBOmVFVVOR NHG0em1IUTVyPUCuNVQ4PiEQvF2= M3;jV|I{OzZyM{S4
PC3 NES0cFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVS3NkBp NWTUd2JrTE2VTx?= NYnwdVZ{UUN3ME2wMlI5KM7:TR?= MUiyNVk5OTdzNB?=
MCF7.1 NFz5OolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXRdI9wPzJiaB?= NUD4OXgzTE2VTx?= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJGhGWjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MV2yNVk5OTdzNB?=
MCF7-neo/Her2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[3NkBp NIny[ppFVVOR NFvBWIpKSzVyPUCuNlkh|ryP NHmzXGEzOzZ4MkmwNy=>
MCF7-neo/Her2 MW\LbY5ie2ViQYPzZZk> NVjUN5ExUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO M4\EflI{PjZ{OUCz
PC3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[2O|IhcA>? NEHVUZFFVVOR MWXFR|UxRTBwM{Sg{txO NIj4dIwzOTl6NU[zPS=>
MCF7.1 NFnXZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTZO|IhcA>? M3mwdmROW09? M3j6fWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFXDOVAhd2ZiMD6zPUDPxE1? MlHWNlE6QDV4M{m=
PC3 M330fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jhWlczKGh? M1y3SmROW09? NH7zbFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> M3S1[|IxODVyNk[5
MCF7.1 M3vORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC1V2ttPzJiaB?= MWLEUXNQ MnvIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? MkOzNlAxPTB4Nkm=
MCF7.1 M134c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPEbYE4OiCq M4DzPWVEPTB;MD63NkDPxE1? MmHlNlA{PDZ4NU[=
NCI-H1975 M3jGU2N6fG:2b4jpZ{BCe3OjeR?= NXrmZ3VCPzJiaB?= M4\4UGlEPTB;MD6yO{DPxE1? NHLZboEzOzB3OUW0OS=>
H460 NIT4PIJEgXSxdH;4bYMhSXO|YYm= Ml32O|IhcA>? MoPuTWM2OD1yLki3JO69VQ>? M3vLRlI{ODV7NUS1
HT-29 MXvDfZRwfG:6aXOgRZN{[Xl? Mnf1O|IhcA>? MUjJR|UxRTBwNk[g{txO MYKyN|A2QTV2NR?=
HepG2 NHTDbnpEgXSxdH;4bYMhSXO|YYm= M{fKXVczKGh? M{[yWWlEPTB;MTFOwG0> M{\4TFI{ODV7NUS1
SGC7901 NELufZpEgXSxdH;4bYMhSXO|YYm= NYrqZpU4PzJiaB?= NHLKXI1KSzVyPUGuPEDPxE1? MonmNlMxPTl3NEW=
NCI-H226 MVnDfZRwfG:6aXOgRZN{[Xl? MWq3NkBp MV3JR|UxRTJwOTFOwG0> NGewWY8zOzB3OUW0OS=>
A549 MYHDfZRwfG:6aXOgRZN{[Xl? Ml3CO|IhcA>? NHmzdJhKSzVyPU[uPUDPxE1? NUnKTlFCOjNyNUm1OFU>
U87MG NEH4UWlEgXSxdH;4bYMhSXO|YYm= MoDJO|IhcA>? M2TwdWlEPTB;Nz63O{DPxE1? NV;2fY9sOjNyNUm1OFU>
HBC4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13hZoxw\0eLNUC9MVYvODNiTR?= M3juTVIzOzN4MkS2
BSY1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPndGtjdG:pR1m1NF0uPi57MDDN NYHlWW1oOjJ|M{[yOFY>
HBC5 NIq1Z2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmxZ4JxdG:pR1m1NF0uPi54MDDN MYmyNlM{PjJ2Nh?=
MCF7 M{\1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHEXG5OdG:pR1m1NF0uPy5|MzDN M3zEZ|IzOzN4MkS2
MDA-MB-231 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle0cI9oT0l3ME2tOU41PiCP NF\PWoczOjN|NkK0Oi=>
U251 NITodlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LTNIxw\0eLNUC9MVUvPTBiTR?= NWjZdm1POjJ|M{[yOFY>
SF268 NXzGc5JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjBV3hPdG:pR1m1NF0uPS5|OTDN MmPXNlI{OzZ{NE[=
SF295 NUnz[Gp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3wTHhtd2eJSUWwQU03NjN5IF2= MkD2NlI{OzZ{NE[=
SF539 NEmxbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfsc4dIUTVyPT22MlUxKE1? NYDIV|I{OjJ|M{[yOFY>
SNB75 NIOxRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q5W4xw\0eLNUC9MVcvOTBiTR?= M{PoWVIzOzN4MkS2
SNB78 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHTbGVtdG:pR1m1NF0uPi53MjDN M{SxdVIzOzN4MkS2
HCC2998 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HxUYxw\0eLNUC9MVYvOjliTR?= NV3ZW4g6OjJ|M{[yOFY>
KM12 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvGRnVtd2eJSUWwQU02Njd4IF2= NFK3VpozOjN|NkK0Oi=>
HT-29 NXPj[2MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3sc4dIUTVyPT22MlMxKE1? MkTRNlI{OzZ{NE[=
HCT15 NETIV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;KcI9oT0l3ME2tOk4yOiCP MnHONlI{OzZ{NE[=
HCT116 M4T4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT0S4dtd2eJSUWwQU02Njh5IF2= NWPsN5U2OjJ|M{[yOFY>
NCI-H23 NYW5PHFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYezbFJ5dG:pR1m1NF0uPS55MzDN Mm\wNlI{OzZ{NE[=
NCI-H226 M{nCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj5SVZkdG:pR1m1NF0uPi5{MTDN NGrrbmkzOjN|NkK0Oi=>
NCI-H522 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli2cI9oT0l3ME2tOk42QCCP NUnZU3FLOjJ|M{[yOFY>
NCI-H483 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHsc4dIUTVyPT22MlU3KE1? MofhNlI{OzZ{NE[=
A549 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS3dYRtd2eJSUWwQU03NjF3IF2= M4nVe|IzOzN4MkS2
DMS273 M2DObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTFcI9oT0l3ME2tOk41OyCP M{PzSVIzOzN4MkS2
DMS114 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjqZmNtd2eJSUWwQU02Njl{IF2= M4PYXlIzOzN4MkS2
LOXIMVI M1\oXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHsc4dIUTVyPT22MlI6KE1? Ml3HNlI{OzZ{NE[=
OVCAR3 NX6x[pdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X1XYxw\0eLNUC9MVYvPzFiTR?= MonpNlI{OzZ{NE[=
OVCAR4 M2L5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\Yb4xw\0eLNUC9MVUvPzZiTR?= M4G3XlIzOzN4MkS2
OVCAR5 NEnkU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEmyR4Vtd2eJSUWwQU03NjJ4IF2= NVfHSJJlOjJ|M{[yOFY>
OVCAR8 MknZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSwcYdndG:pR1m1NF0uPS55MzDN NHHtNIgzOjN|NkK0Oi=>
SKOV3 NEDk[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDsc4dIUTVyPT22MlUzKE1? NIfPPI0zOjN|NkK0Oi=>
RXF631L MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\pUIxw\0eLNUC9MVYvQDhiTR?= MWeyNlM{PjJ2Nh?=
ACHN NF;hSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vXSIxw\0eLNUC9MVYvODdiTR?= NW\lO3M4OjJ|M{[yOFY>
St-4 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjweJpSdG:pR1m1NF0uPS53NjDN MoDDNlI{OzZ{NE[=
MKN1 M2f1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O0fIxw\0eLNUC9MVcvODhiTR?= NYG3U4d4OjJ|M{[yOFY>
MKN7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\2cYxw\0eLNUC9MVYvPTBiTR?= MVmyNlM{PjJ2Nh?=
MKN28 M2LOT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHsc4dIUTVyPT21MlUzKE1? Ml;1NlI{OzZ{NE[=
MKN45 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXsc4dIUTVyPT22MlU2KE1? M2T1fFIzOzN4MkS2
MKN74 NV\1bGtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\sc4dIUTVyPT22MlAzKE1? NWewRmtUOjJ|M{[yOFY>
DU145 NH\HSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jOVYxw\0eLNUC9MVUvQDViTR?= NX\aUFRmOjJ|M{[yOFY>
PC3 NWXpNYFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPFUHBtd2eJSUWwQU03NjZ4IF2= NV;y[IszOjJ|M{[yOFY>
ES5 NYnUbHJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT5TWM2OD13MD6yNUBvVQ>? NFmzR3hUSU6JRWK=
HH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS2dYlKSzVyPUGxNU4xQCCwTR?= MkHEV2FPT0WU
MHH-PREB-1 NV;LblBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfjbowzUUN3ME2xNVQvOyCwTR?= MV\TRW5ITVJ?
NCI-H1770 NHXxNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK1TWM2OD1zMkOuPFYhdk1? Mo\kV2FPT0WU
HuO9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\3OWZlUUN3ME2yNFYvODJibl2= NGWyUWNUSU6JRWK=
HAL-01 NED0Z3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jDfmlEPTB;MkC2Mlc{KG6P MV;TRW5ITVJ?
NOS-1 MnHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3lcHdKSzVyPUKxNU45OiCwTR?= NUfiT5ZNW0GQR1XS
HGC-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfJTWM2OD1{MUKuOVchdk1? MlLsV2FPT0WU
NB69 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj2b3Y5UUN3ME2yOFUvOjdibl2= NWP1VGRtW0GQR1XS
RS4-11 MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW2XFVnUUN3ME2yOlEvPzZibl2= NFGzZ2VUSU6JRWK=
DOK MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNyMT63JI5O NFfsS5dUSU6JRWK=
LB2241-RCC MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rR[2lEPTB;M{CzMlg1KG6P NXzodnVoW0GQR1XS
NCI-H1623 NH3l[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K5XGlEPTB;M{C0MlA5KG6P MmrzV2FPT0WU
YH-13 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjYTWM2OD1|MESuN|Ihdk1? MkDGV2FPT0WU
BPH-1 NHXQ[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni5TWM2OD1|MUSgcm0> MmDJV2FPT0WU
AN3-CA NFz6T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\URnNKSzVyPUO0NE4{PyCwTR?= NGTDeolUSU6JRWK=
ES7 M1naTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN2MT65PUBvVQ>? NVPxNnJMW0GQR1XS
MDA-MB-175-VII NWCyZ|l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTN3Mj65NkBvVQ>? MoLJV2FPT0WU
GAMG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN5MD64OUBvVQ>? NFTlN|dUSU6JRWK=
CHL-1 NELZXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi1PGtKSzVyPUO3PE43PSCwTR?= MULTRW5ITVJ?
NB7 MoflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHBTVZKSzVyPUO4PU45OyCwTR?= MVTTRW5ITVJ?
MFE-280 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRzOD6yJI5O M{nTOnNCVkeHUh?=
HL-60 NWXYWHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTR{NT63OUBvVQ>? NYrJZnlmW0GQR1XS
GCIY NFTaSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfEUXp3UUN3ME20N|MvQCCwTR?= M1X6bnNCVkeHUh?=
MDA-MB-361 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnywTWM2OD12M{muNVMhdk1? MWrTRW5ITVJ?
LXF-289 M2TPOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR2OD6yO{BvVQ>? NFuzU3ZUSU6JRWK=
NBsusSR M{XoNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vocmlEPTB;NEi4Mlg2KG6P Ml\aV2FPT0WU
KU-19-19 NUTyeZZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTVzNj6wO{BvVQ>? NFW3VmpUSU6JRWK=
A204 NELZeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki0TWM2OD13MkKuN|Mhdk1? NVXvO4ViW0GQR1XS
LB1047-RCC NUnrdGFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXWTWM2OD13MkKuPVMhdk1? M3rWZXNCVkeHUh?=
COLO-684 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\GTWM2OD13MkOuNVEhdk1? MkXCV2FPT0WU
PA-1 NHnRNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTV|Mj60NUBvVQ>? NWjaOnJkW0GQR1XS
MG-63 NEjGc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\RSoVKSzVyPUW0NU4yOSCwTR?= MmH3V2FPT0WU
BHT-101 NY\wNVBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ntVGlEPTB;NUS0Mlk1KG6P MkTkV2FPT0WU
NKM-1 M1LhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjXZWJKSzVyPUW5N{4xQSCwTR?= NXizRWg3W0GQR1XS
T47D MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nteGlEPTB;NUm3MlU3KG6P M2TmWnNCVkeHUh?=
MOLT-4 NGjz[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjvTWM2OD14MkOuOlIhdk1? NVXPUZRtW0GQR1XS
IGROV-1 NXvhfZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn4b2tKSzVyPU[zOE4{OSCwTR?= M4\tOnNCVkeHUh?=
ES4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXUTWM2OD14M{muOVQhdk1? NYDCUGJyW0GQR1XS
HuO-3N1 M{C2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\YXmlEPTB;NkSyMlM5KG6P MoC0V2FPT0WU
NEC8 M1zKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DZXGlEPTB;NkWzMlU4KG6P M3LYRnNCVkeHUh?=
HO-1-N-1 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX0TWM2OD14NUmuNVchdk1? MnznV2FPT0WU
EPCL-272H NF[4OIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPIbJBmUUN3ME22PFcvOjFibl2= NHezR5RUSU6JRWK=
D-263MG M4HsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PwOGlEPTB;N{G4MlEhdk1? Mn;RV2FPT0WU
MV-4-11 NWO2ZoN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlOwTWM2OD15MkSuN|Ehdk1? M4LNenNCVkeHUh?=
SK-NEP-1 M{GyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrieGNFUUN3ME23NlUvQTRibl2= NV7lNWZPW0GQR1XS
SW872 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES2blBKSzVyPUeyO{45QSCwTR?= MnG2V2FPT0WU
P30-OHK M1fKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\IemlEPTB;N{OwMlcyKG6P M1f6fHNCVkeHUh?=
OMC-1 M37Jb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIraT4NKSzVyPUe1NU4xQSCwTR?= NYDWV5E6W0GQR1XS
LoVo NWXDOFdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;hfFhKSzVyPUe3O{46KG6P NGD6VYJUSU6JRWK=
LNCaP-Clone-FGC NWWyUZdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn2TpBVUUN3ME23PVYvOzRibl2= MUHTRW5ITVJ?
L-363 M3rjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WzVGlEPTB;N{m4MlQzKG6P NVHqUnBuW0GQR1XS
ES8 MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvES5ZsUUN3ME24NVAvPTJibl2= NILhPYxUSU6JRWK=
697 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTh|MT61OUBvVQ>? M2mzbXNCVkeHUh?=
HSC-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[wTWM2OD16M{muOVQhdk1? MUHTRW5ITVJ?
H4 NFPaTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\MTWM2OD16NUCuPFUhdk1? NUXG[WlNW0GQR1XS
QIMR-WIL NUe2PItsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK0VlJnUUN3ME24OlUvOiCwTR?= NH[1V|RUSU6JRWK=
OAW-42 NWXFPHA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHlcndmUUN3ME24O|IvOTlibl2= MYXTRW5ITVJ?
MCF7 M1\uWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\pZ5dKSzVyPUi5PE42QSCwTR?= NWrxe|N[W0GQR1XS
SCC-25 NEPobG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojBTWM2OD17MUSuNVkhdk1? MkDWV2FPT0WU
NCI-H1563 M3;ndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnrTWM2OD17MUWuPVkhdk1? MVzTRW5ITVJ?
OVCAR-5 M4TLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;0T2lEPTB;OUSwMlE4KG6P M{HEUHNCVkeHUh?=
HDLM-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTl2OT6yJI5O NGH2[XNUSU6JRWK=
NB5 NGr5N3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrWTWM2OD17NU[uOkBvVQ>? NFznepJUSU6JRWK=
NCI-H292 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTl5ND6zNkBvVQ>? MVjTRW5ITVJ?
A101D Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf3fJRUUUN3ME25PVAvOTlibl2= NWPtN4E2W0GQR1XS
NCI-H1648 NUfsU3hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TSemlEPTB;OUm4MlUyKG6P MlvWV2FPT0WU
EKVX MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPNNYpKSzVyPUGuNFEzQSEQvF2= M4Dre3NCVkeHUh?=
SW1710 NVLMd3dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO5fVFoUUN3ME2xMlA1OjN|IN88US=> MmjsV2FPT0WU
WM-115 M3HLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwME[2OVYh|ryP Ml;SV2FPT0WU
CAL-54 NVTkSYZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TINWlEPTB;MT6wO|A5OSEQvF2= MlvHV2FPT0WU
TGBC24TKB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwMEiwOFUh|ryP M3L1eHNCVkeHUh?=
NCI-H520 NW\uO4N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPpbZBKSzVyPUGuNFg6PjdizszN NWH1T2FuW0GQR1XS
D-423MG M2nUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnMdnBKSzVyPUGuNFk6PjJizszN NHOwbm5USU6JRWK=
BFTC-905 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjTWGVKSzVyPUGuNVM1PDlizszN NWHiSVJzW0GQR1XS
HT M1ruWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe4XZhKSzVyPUGuNVM1PzhizszN MoLyV2FPT0WU
CTB-1 NV;wbmt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwMUSyPVMh|ryP M3TLfnNCVkeHUh?=
Hs-578-T NHzBXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwMUm1OlUh|ryP MnnuV2FPT0WU
HuH-7 NX3FemxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLvTWM2OD1zLkKwPVQ6KM7:TR?= NUjNfGs2W0GQR1XS
LB996-RCC NHu5UWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTXS3VUUUN3ME2xMlIzOTd5IN88US=> MlX0V2FPT0WU
KYSE-270 M4HNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HYd2lEPTB;MT6yPVc{PCEQvF2= M3L1b3NCVkeHUh?=
A4-Fuk NEfBO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX0NGVKSzVyPUGuNlk6QTNizszN MoDvV2FPT0WU
A498 M3zEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFwM{C0O|Qh|ryP M2ezOnNCVkeHUh?=
SK-MEL-1 M4XCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPFTWM2OD1zLkOwOlc6KM7:TR?= NULNPGRCW0GQR1XS
AU565 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHCTWM2OD1zLkOxPFY{KM7:TR?= M2nIbXNCVkeHUh?=
Saos-2 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX3RZFKSzVyPUGuN|MzODVizszN Mmi1V2FPT0WU
A549 NIG0W4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTQdYtIUUN3ME2xMlM6QTdizszN NF3GRmtUSU6JRWK=
BFTC-909 Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLUeGxpUUN3ME2xMlQ{OzB3IN88US=> NF3QVVNUSU6JRWK=
MDA-MB-415 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzQTWM2OD1zLkS4OlkzKM7:TR?= NWX2PYdFW0GQR1XS
639-V NUK0[HRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\RTWZKSzVyPUGuOVAzPDVizszN NEHqOIdUSU6JRWK=
A704 M3jxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr1c3NKSzVyPUGuOVA4QDVizszN MVvTRW5ITVJ?
PANC-03-27 M1;CWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwNUG0NFgh|ryP MlPIV2FPT0WU
SK-MEL-28 M2PzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[xbWlEPTB;MT61OlA5PSEQvF2= MlXGV2FPT0WU
Ramos-2G6-4C10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwNkC3OFYh|ryP MYrTRW5ITVJ?
HuP-T4 MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwNkC3O|gh|ryP NXPyWXlrW0GQR1XS
VA-ES-BJ NXPFc4RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH3OIdKSzVyPUGuOlEzPyEQvF2= NGrWSWtUSU6JRWK=
EFM-19 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzhTWM2OD1zLk[xPFEh|ryP MknuV2FPT0WU
G-401 MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrVT5FYUUN3ME2xMlYzOTZ2IN88US=> MUXTRW5ITVJ?
D-566MG NHXYXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnuTWM2OD1zLk[yOVMh|ryP NIjEdXJUSU6JRWK=
JVM-3 M4fETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnlTWM2OD1zLk[0PFc2KM7:TR?= Mlq1V2FPT0WU
TK10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe1PWgyUUN3ME2xMlY4ODh|IN88US=> NX7qTm9wW0GQR1XS
BT-20 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLHTWM2OD1zLk[4PVAzKM7:TR?= MVnTRW5ITVJ?
EGI-1 MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX5eFVPUUN3ME2xMlg1PzBzIN88US=> NEPxfmJUSU6JRWK=
EW-16 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwOEWxPFIh|ryP M{XUWHNCVkeHUh?=
NCI-H2228 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrCRolKSzVyPUGuPFUzODNizszN MWXTRW5ITVJ?
BB49-HNC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULy[nM4UUN3ME2xMlg5Pjl{IN88US=> Mn7JV2FPT0WU
G-402 Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jMO2lEPTB;MT64PVc6PyEQvF2= MYTTRW5ITVJ?
NCI-H526 Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwOUGzPUDPxE1? NILtbZdUSU6JRWK=
ME-180 NHj0W|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXQTWM2OD1zLkmzOFc4KM7:TR?= MmnwV2FPT0WU
PFSK-1 M2GyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwOUS0OVgh|ryP NH7hUo9USU6JRWK=
TYK-nu M4rXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwOUW4NlMh|ryP MULTRW5ITVJ?
HOS M2TP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvCPYJKSzVyPUGuPVc6PDhizszN MmXiV2FPT0WU
T98G MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4mwcmlEPTB;MT65PVAxPiEQvF2= NGTQTZdUSU6JRWK=
SK-MES-1 NF7wc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PQSmlEPTB;Mj6wNVM{OiEQvF2= M3j0WXNCVkeHUh?=
SNB75 M1\JO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJwMEG1OFEh|ryP M{XDSXNCVkeHUh?=
LAMA-84 MmiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7SN4JZUUN3ME2yMlAzPjh7IN88US=> M2TTRXNCVkeHUh?=
CAL-39 M2jhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv6WWdKSzVyPUKuNFMzQCEQvF2= MVfTRW5ITVJ?
LOXIMVI NE\mPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSwTWM2OD1{LkC0NFg1KM7:TR?= NYezd|BtW0GQR1XS
NH-12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwMEW0NlQh|ryP NFnt[|lUSU6JRWK=
NCI-H1048 NULFWXFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETtSWNKSzVyPUKuNVA2OiEQvF2= NFPT[W1USU6JRWK=
KS-1 M{PqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJwMUGwNFEh|ryP NFH4R2RUSU6JRWK=
NCI-N87 M2XqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTpZ5JKSzVyPUKuNVM{QDRizszN MoDkV2FPT0WU
CHP-212 NF;RXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3zRYZzUUN3ME2yMlE5PDR{IN88US=> MWXTRW5ITVJ?
HCC1419 NF3ZWlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj6TJp3UUN3ME2yMlIyOTF3IN88US=> M17mbnNCVkeHUh?=
ES1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrOTWM2OD1{LkKxN|I3KM7:TR?= NYm2bVVrW0GQR1XS
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MC-IXC Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j4UWlEPTB;Nz60NVk4OiEQvF2= MX\TRW5ITVJ?
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J82 M2C0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPVXJJKSzVyPUiuNlk1QTFizszN M1\BUnNCVkeHUh?=
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U-87-MG NH;FcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHLcWZEUUN3ME25MlI1OzJzIN88US=> MU\TRW5ITVJ?
MN-60 NHS2WoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTlwMkS1OFIh|ryP NVGwPFFqW0GQR1XS
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DEL NFPHRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LQPWlEPTB;MUCuN|c6PCEQvF2= NGXicndUSU6JRWK=
HT55 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT6RmQ{UUN3ME2xNE43OjB3IN88US=> M1zWVXNCVkeHUh?=
MC116 NFTDNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzvc|NKSzVyPUGwMlY3PTVizszN M13XRXNCVkeHUh?=
BB30-HNC NWr4R2VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\jRmlEPTB;MUCuOlY6KM7:TR?= M3zSN3NCVkeHUh?=
DJM-1 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFyLk[5OFkh|ryP MV;TRW5ITVJ?
ZR-75-30 M2rw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrw[5pbUUN3ME2xNE46PDRzIN88US=> MlrFV2FPT0WU
U-118-MG NF\vTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW0TWM2OD1zMD65PFk3KM7:TR?= NIjvZXFUSU6JRWK=
MSTO-211H NFPafGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fubWlEPTB;MUGuNFcyPiEQvF2= NFHMUG5USU6JRWK=
SW837 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\wTWM2OD1zMT6wPVQ6KM7:TR?= NGniZplUSU6JRWK=
HuCCT1 NHHxcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqwcpFKSzVyPUGxMlEzQDFizszN NHv3eZJUSU6JRWK=
RCC10RGB NUL1UnV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFzLkGzOUDPxE1? MXnTRW5ITVJ?
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NCI-H650 NHTIfolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PtT2lEPTB;MUGuN|c6PCEQvF2= MUnTRW5ITVJ?
HEC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFzLkSzNlgh|ryP NFv6d5dUSU6JRWK=
DU-4475 NELpUpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362VGlEPTB;MUGuO|M6OyEQvF2= MVvTRW5ITVJ?
DSH1 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjHRmNYUUN3ME2xNU44PjB4IN88US=> MWTTRW5ITVJ?
HCC1569 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X3Z2lEPTB;MUGuO|Y4QCEQvF2= Mlz3V2FPT0WU
HCC1187 NH;JT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32wRmlEPTB;MUGuPFU5QCEQvF2= M1HFNXNCVkeHUh?=
EW-11 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nNSGlEPTB;MUGuPVQ4PCEQvF2= MmTGV2FPT0WU
LB2518-MEL NGTRe21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPxTWM2OD1zMj6wOVkh|ryP MVzTRW5ITVJ?
KALS-1 NXznXohGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfNNFBKSzVyPUGyMlg2PTNizszN Mn\TV2FPT0WU
8505C NUH4NmJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm3VIZvUUN3ME2xNk45QDVizszN NHfxRW1USU6JRWK=
SK-N-DZ MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF|LkC0OVMh|ryP NXrnRlM5W0GQR1XS
CHP-134 NHfmeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P4cmlEPTB;MUOuNVE2QCEQvF2= NHfjT|RUSU6JRWK=
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LB-831-BLC NF\sW5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u0TmlEPTB;MUOuOlI1PiEQvF2= NXu4WGxXW0GQR1XS
OVCAR-4 NIDaepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTF|Lk[1NlQh|ryP MUfTRW5ITVJ?
SW756 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF|LkeyOFYh|ryP NITocoxUSU6JRWK=
OCUB-M MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PqdmlEPTB;MUOuPFE2PiEQvF2= M{Xj[XNCVkeHUh?=
SW982 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTqXHBpUUN3ME2xN{45Ojd4IN88US=> NFe3cWVUSU6JRWK=
DB NX\VTJlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrQd4xzUUN3ME2xN{45Ozh2IN88US=> NEPndoNUSU6JRWK=
H-EMC-SS Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXE[JRtUUN3ME2xN{46OTN7IN88US=> M3TBcXNCVkeHUh?=
VMRC-RCZ NF\qVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LUbmlEPTB;MUSuNFAyPSEQvF2= MULTRW5ITVJ?
CAKI-1 M4TvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHEZldKUUN3ME2xOE4xOTN{IN88US=> NIjyV2lUSU6JRWK=
GI-1 NF7mWHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTF2LkC2OVgh|ryP NUW4U5RDW0GQR1XS
Ca9-22 NFu0eIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPFXJd5UUN3ME2xOE43ODV2IN88US=> Moj4V2FPT0WU
TE-5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjhflZMUUN3ME2xOE44OjB6IN88US=> MmDaV2FPT0WU
EFO-27 NYLYXGdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnvRY1GUUN3ME2xOE44PjJ{IN88US=> MYXTRW5ITVJ?
CAL-72 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jsNGlEPTB;MUSuO|c5OyEQvF2= NWjmVW1GW0GQR1XS
GP5d M3nCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHoSZZKSzVyPUG1MlA1PzRizszN NUKyPItSW0GQR1XS
CAS-1 NELnflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\yTWM2OD1zNT6wOlYh|ryP MWHTRW5ITVJ?
A2058 NGqxcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[2TWM2OD1zNT61OlM5KM7:TR?= NEXLflZUSU6JRWK=
PANC-08-13 NHXxWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Qb491UUN3ME2xOU43QDV7IN88US=> M2TKNXNCVkeHUh?=
Detroit562 NWXx[3lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF3LkmxN|kh|ryP NWrETZo2W0GQR1XS
PANC-10-05 M1;Dbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TaSWlEPTB;MU[uNFgzOSEQvF2= M4f0T3NCVkeHUh?=
KOSC-2 NEnnNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfES5hKSzVyPUG2MlEyOjVizszN MmS4V2FPT0WU
GT3TKB NX;Fc|VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HGcGlEPTB;MU[uNVk5OSEQvF2= Mmf4V2FPT0WU
KM-H2 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOwTWM2OD1zNj6zOlQ3KM7:TR?= MmfWV2FPT0WU
LB771-HNC NFL2WnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LDTWlEPTB;MU[uOFQzOiEQvF2= MmjFV2FPT0WU
SF268 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrSN3BKSzVyPUG2MlQ2OiEQvF2= NEjaV5pUSU6JRWK=
OE19 NILyZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH63UllKSzVyPUG2MlUzPCEQvF2= NXTPd3I2W0GQR1XS
MLMA NYXtN406T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmS4TWM2OD1zNj61OVcyKM7:TR?= M3XoZXNCVkeHUh?=
MDA-MB-231 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\q[IlbUUN3ME2xOk44OTN4IN88US=> NHzBeItUSU6JRWK=
TGW NFfKWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;2OmhvUUN3ME2xOk45OTB{IN88US=> NH72SWVUSU6JRWK=
MDA-MB-453 NH\sWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTF5LkCwNFMh|ryP MXrTRW5ITVJ?
SNU-C2B MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK3XodKSzVyPUG3MlAzOzdizszN MXrTRW5ITVJ?
A427 NVL1WZR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnFTWM2OD1zNz6yN|M1KM7:TR?= NWPHTZY2W0GQR1XS
SK-MEL-2 NWjQ[ohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zEfGlEPTB;MUeuN|IyOyEQvF2= Mlq1V2FPT0WU
KURAMOCHI MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TVd2lEPTB;MUeuN|g6PyEQvF2= MkPtV2FPT0WU
IST-MEL1 NV23SHFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzScJZjUUN3ME2xO{46OTh{IN88US=> NVzHcFB4W0GQR1XS
NCI-H1793 NULPTm1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\UWGQzUUN3ME2xPE4yPThzIN88US=> NILHWIhUSU6JRWK=
HCC1395 NEjCUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHpTGxKSzVyPUG4MlU3OTFizszN MVTTRW5ITVJ?
NUGC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfzOJNKSzVyPUG4MlY2QDRizszN NFPmb3lUSU6JRWK=
BB65-RCC M1Lpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi2TWM2OD1zOD62Olkh|ryP M2TOWnNCVkeHUh?=
RMG-I NFHPZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu5TWM2OD1zOD63N|gzKM7:TR?= MWXTRW5ITVJ?
LS-513 NHLCNXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CzU2lEPTB;MUiuPVIzQCEQvF2= NFywdXJUSU6JRWK=
MFM-223 MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\uRWlEPTB;MUmuNFcyPiEQvF2= Moe5V2FPT0WU
NCI-H727 M4DzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TPc2lEPTB;MUmuN|I6PSEQvF2= Mni0V2FPT0WU
KP-4 NH3t[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jteWlEPTB;MUmuPFU{OSEQvF2= M4\BdnNCVkeHUh?=
NB13 NGP0coZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF7Lki4N|kh|ryP M1KxVXNCVkeHUh?=
UACC-893 NWXScpRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Oye2lEPTB;MUmuPVc2PyEQvF2= NF;EeZlUSU6JRWK=
HT-1197 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInVRotKSzVyPUKwMlI6PThizszN NYnGbVR7W0GQR1XS
NCI-H2029 M2Pr[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rFS2lEPTB;MkCuN|I3PiEQvF2= MmXpV2FPT0WU
GI-ME-N MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m4SmlEPTB;MkCuN|M4OyEQvF2= Ml\DV2FPT0WU
OVCAR-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;reGlEPTB;MkCuOVgzOiEQvF2= NXfkWINOW0GQR1XS
HD-MY-Z Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M120cWlEPTB;MkGuN|Y6PiEQvF2= MkXjV2FPT0WU
NTERA-S-cl-D1 Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD1{MT62O|IzKM7:TR?= NVXKSGFEW0GQR1XS
SCH NVLVWVlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ{LkS5OkDPxE1? NETpeFBUSU6JRWK=
KARPAS-299 M3nZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDke21KSzVyPUKzMlM5QDdizszN NWrDUYU3W0GQR1XS
NCI-H1650 M37XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJ|LkmyOFEh|ryP NYHwbXVnW0GQR1XS
ACHN NIruVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPxSYRKSzVyPUK0MlQ3PTZizszN MlrzV2FPT0WU
M059J NEmwUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjCTWM2OD1{ND61OlM1KM7:TR?= NGrPR|VUSU6JRWK=
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NCI-H1395 NFjsSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LkcWlEPTB;MkeuO|g{OyEQvF2= MmPIV2FPT0WU
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SW13 NXTZd|V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn1TWM2OD1{OT64OVE6KM7:TR?= NYK4coZkW0GQR1XS
ES3 M{TBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\MU2pDUUN3ME2zNE4{PzN|IN88US=> NYLDbplpW0GQR1XS
HCT-116 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNyLkW1OVQh|ryP NGnJR|NUSU6JRWK=
NCI-H1693 NUHsRY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTrTWM2OD1|MD61PVQzKM7:TR?= MXrTRW5ITVJ?
VM-CUB-1 M{XYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHVTWM2OD1|MD62OFE{KM7:TR?= M4HrVHNCVkeHUh?=
NCI-H2170 M2O2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmmzTWM2OD1|MT61O|g1KM7:TR?= M{DxfHNCVkeHUh?=
ALL-PO M3jOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M131fWlEPTB;M{GuPFQzQCEQvF2= Ml7WV2FPT0WU
NCI-H661 NHjLSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn2XZZKSzVyPUOyMlA3OjNizszN NXW1Nm1{W0GQR1XS
NCI-H2347 NWjC[HJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTN{LkS4N|ch|ryP M2jkdHNCVkeHUh?=
FTC-133 M3zPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN{LkewOkDPxE1? NIC0PWlUSU6JRWK=
COLO-829 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7xXVY4UUN3ME2zN{4{PDZ5IN88US=> M4X2bHNCVkeHUh?=
GOTO MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[zdGxqUUN3ME2zN{42OjV6IN88US=> NF\TXVZUSU6JRWK=
YAPC NX\hdHVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H0NmlEPTB;M{OuPFE2QSEQvF2= NVzJS2NOW0GQR1XS
LCLC-103H MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTN2LkG2NlQh|ryP MVnTRW5ITVJ?
SiHa MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmcIlKSzVyPUO0MlM5OTdizszN NGe4WlFUSU6JRWK=
LK-2 NF\Jb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DFVWlEPTB;M{SuOVcxQCEQvF2= NVfYcm9bW0GQR1XS
KP-N-YS M3rxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGxTWM2OD1|ND63NlAzKM7:TR?= NFf1O4pUSU6JRWK=
NCI-SNU-1 NWLJeZdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjtTWM2OD1|NT6xO|kh|ryP NUTFWmI6W0GQR1XS
KNS-81-FD NULueFdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTN3Lk[2N{DPxE1? NEG2ZWdUSU6JRWK=
SCC-9 M4fsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHCTo5PUUN3ME2zOk44OTR4IN88US=> M{fiSXNCVkeHUh?=
SH-4 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe1XIZrUUN3ME2zOk44OyEQvF2= MV;TRW5ITVJ?
HCC-1954 NVfDTFRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;HXZlKSzVyPUO3MlI4OjlizszN M1rHfHNCVkeHUh?=
BALL-1 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILiV4FKSzVyPUO3MlU{OTZizszN MnOxV2FPT0WU
BE-13 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7qcGUxUUN3ME2zO{44ODF6IN88US=> MUHTRW5ITVJ?
COLO-678 Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLiTWM2OD1|Nz65OFM4KM7:TR?= MnXmV2FPT0WU
SK-MEL-3 M{nKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmwcJBKSzVyPUO4MlI{QTdizszN MVjTRW5ITVJ?
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CAMA-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfpTYFKSzVyPUO4Mlk3QTFizszN NFriOZFUSU6JRWK=
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A3-KAW NFm0PG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjZTWM2OD12MD6zOlYyKM7:TR?= NYrqSldoW0GQR1XS
SK-MEL-24 M1HSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HTVWlEPTB;NECuOVk{OSEQvF2= MVvTRW5ITVJ?
KYSE-140 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;NTWM2OD12MD63NVY2KM7:TR?= NGDo[2FUSU6JRWK=
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CFPAC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR{LkWyNVEh|ryP Mnr3V2FPT0WU
NB14 NGHPdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrUe4JKSzVyPUSyMlcxOjdizszN NV;YW2xVW0GQR1XS
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RH-1 NFi5cJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\0U5d1UUN3ME20N{41QDN4IN88US=> MWnTRW5ITVJ?
NCI-H522 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrzNnZsUUN3ME20OE4{PTZ6IN88US=> MVvTRW5ITVJ?
Ca-Ski MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTRfJpKUUN3ME20OE45OTF2IN88US=> MoHFV2FPT0WU
KGN M1jCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjNTWM2OD12OD6zNFY{KM7:TR?= MmC2V2FPT0WU
UACC-62 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorXTWM2OD12OD60NFczKM7:TR?= NGn5TnBUSU6JRWK=
NCI-H358 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LKSGlEPTB;NEmuN|AyQCEQvF2= MmXaV2FPT0WU
LS-411N NFLmc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR7LkOxNVgh|ryP MlTTV2FPT0WU
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

- Collapse

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

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  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321
Smiles CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID