Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 114 Publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NHn4eFNMcW6jc3WgRZN{[Xl? MXuxJIg> MYLEUXNQ MnS0TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP NVvuSHF6OTh5NUS2OVQ>
Sf9 NFu0bIxMcW6jc3WgRZN{[Xl? NG\iWZMyKGh? M1qxbmROW09? NV7MUmdLUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEhzMES3MXIhdXW2YX70JIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? NEHXZVQyQDd3NE[1OC=>
Sf9 MUfLbY5ie2ViQYPzZZk> MYOxJIg> NUXVTm5qTE2VTx?= NWjXS3ZiUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEV3NEWtT{BufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NIjuR|cyQDd3NE[1OC=>
Sf9 NHjRbVZMcW6jc3WgRZN{[Xl? NX\YWIFHOSCq M13UfGROW09? NH\1U|NKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= M3HBWlE5PzV2NkW0
Sf9 M4PpfGtqdmG|ZTDBd5NigQ>? NUnKR2lLOSCq NGTFUm9FVVOR NHe3XnpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHHsdIhiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhi Ml3WNVg4PTR4NUS=
MDA-MB-361 MnTpSpVv[3Srb36gRZN{[Xl? MYWyJIg> M1LSeWROW09? NWH5XoJuUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO NHjiPXEyQDd3NE[1OC=>
PC3 M4PncWZ2dmO2aX;uJGF{e2G7 NHm5eY4zKGh? NWW2XYtMTE2VTx?= M3X2SWlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGDDN{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yM{eg{txO NYD0RYJ2OTh5NUS2OVQ>
U87MG NVXKS2VKTnWwY4Tpc44hSXO|YYm= MnzrNkBp MYfEUXNQ NG\iWGVKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP NHW0dXAyQDd3NE[1OC=>
MDA-MB-361 M1rRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXLPVYhcA>? M1vSfmROW09? NY[wbm1ISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC55MjFOwG0> NFLWNIwyQDd3NE[1OC=>
A2780 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILKfVU6PiCq NVPvXJd6TE2VTx?= NF;TUlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGyO|gxKGOnbHzzJJdqfGhiUFnLN2NCKGGwZDDQWGVPKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlE1KM7:TR?= NWnNcWdDOTh5NUS2OVQ>
PC3 Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvlSXo4QTZiaB?= M1PhO2ROW09? Ml\1TWM2OD1yLkK4JO69VQ>? MmnLNVg4PTR4NUS=
U87MG NYHQVo1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\wV|A6PiCq NW\ye3ZCTE2VTx?= NHXv[HNKSzVyPUCuPVUh|ryP NUf2V|d4OTh5NUS2OVQ>
Sf9 NHfoNodMcW6jc3WgRZN{[Xl? NEPoboE{OCCvaX6= MVXEUXNQ MoXKTY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHHtc5VvfCCxZjDBWHAh[2:wc4Xt[YQhf2m2aDDJR|UxKG:oIECuNFQzKM7:TR?= NW[xeGlFOjJ3NEizOFI>
RAW 264.7 MmXnT4lv[XOnIFHzd4F6 M1XiZVkxKG2rbh?= NYHMR2JyTE2VTx?= MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= MXyyNlU1QDN2Mh?=
Sf9 M4[yV2tqdmG|ZTDBd5NigQ>? NF\UXFIyKGh? M3f1S2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tj\XSjIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVRkmgZ4VtdHNid3n0bEBKSzVyIH;mJFAvODF5IN88US=> NUTN[nM{OjN3NEC2OFU>
Sf9 NFrV[4NMcW6jc3WgRZN{[Xl? MXuxJIg> M{[2[WlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= M3jCfVI{PTRyNkS1
Sf9 NV;I[Gp1U2mwYYPlJGF{e2G7 NYKwXlgzOSCq NIq3T|VKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\2GvbXGg[ZhxemW|c3Xk NYHudFFoOjN3NEC2OFU>
Sf9 M4joTGtqdmG|ZTDBd5NigQ>? M3jyeVEhcA>? NELEe|NKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk MlrCNlM2PDB4NEW=
SKOV3 M4DEVWtqdmG|ZTDBd5NigQ>? MXixJO69VQ>? M4SwcVEhcA>? NYTmSmNZTE2VTx?= NF2xPVZKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:w NWfJeVBWOjN|NkCzOFg>
MCF7 NVzETVBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[zUYwyKM7:TR?= MmLSPVYhcA>? MkSySG1UVw>? MXrHTVUxRTBwMEewNkDPxE1? MUSyN|M3ODN2OB?=
SKOV3 NIX6fG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m4ZVEh|ryP Mk\WPVYhcA>? NYG2XlFUTE2VTx?= NH3YbVBIUTVyPUCuNVQ4PiEQvF2= NYHxZ3dUOjN|NkCzOFg>
PC3 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX5cpg4OiCq NXO1bY1kTE2VTx?= NVrxNGxTUUN3ME2wMlI5KM7:TR?= MYCyNVk5OTdzNB?=
MCF7.1 M3nXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe4eng4OiCq MljwSG1UVw>? NGnxfG9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKEiHUkKg[4Vv\SC5aYToJGlEPTBib3[gNE4zQCEQvF2= MkTjNlE6QDF5MUS=
MCF7-neo/Her2 M3S2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnFO|IhcA>? NYHKR|I1TE2VTx?= M2O3eWlEPTB;MD6yPUDPxE1? NYjKNoJ7OjN4NkK5NFM>
MCF7-neo/Her2 NH7jTnRMcW6jc3WgRZN{[Xl? MnnsTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN M4O0S|I{PjZ{OUCz
PC3 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOwPIhnPzJiaB?= MnzOSG1UVw>? MXfFR|UxRTBwM{Sg{txO NVe0OlRXOjF7OEW2N|k>
MCF7.1 M4PsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfnO|IhcA>? NGLoc5FFVVOR M{nEV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFXDOVAhd2ZiMD6zPUDPxE1? NGfU[HAzOTl6NU[zPS=>
PC3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHwNnFnPzJiaB?= Mn;tSG1UVw>? Ml;DRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN MnnYNlAxPTB4Nkm=
MCF7.1 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HoeFczKGh? MWDEUXNQ MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO NVu4epI5OjByNUC2Olk>
MCF7.1 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPyWpE4OiCq MoDKSWM2OD1yLkeyJO69VQ>? NH;HWlQzODN2Nk[1Oi=>
NCI-H1975 MV3DfZRwfG:6aXOgRZN{[Xl? MX:3NkBp M3nLV2lEPTB;MD6yO{DPxE1? MXeyN|A2QTV2NR?=
H460 MX7DfZRwfG:6aXOgRZN{[Xl? MlvpO|IhcA>? NHHVOnJKSzVyPUCuPFch|ryP MnLoNlMxPTl3NEW=
HT-29 MUPDfZRwfG:6aXOgRZN{[Xl? NFXjbmc4OiCq NYnDUoZ1UUN3ME2wMlY3KM7:TR?= Ml\uNlMxPTl3NEW=
HepG2 NIjheGVEgXSxdH;4bYMhSXO|YYm= MUe3NkBp MofNTWM2OD1zIN88US=> NVLJRWpROjNyNUm1OFU>
SGC7901 M1G1[2N6fG:2b4jpZ{BCe3OjeR?= NFvLRnA4OiCq NFjNeJJKSzVyPUGuPEDPxE1? MXuyN|A2QTV2NR?=
NCI-H226 MnPhR5l1d3SxeHnjJGF{e2G7 M3n3dlczKGh? MXTJR|UxRTJwOTFOwG0> MoruNlMxPTl3NEW=
A549 MlHkR5l1d3SxeHnjJGF{e2G7 M3jLW|czKGh? MXXJR|UxRTZwOTFOwG0> NIPvd5EzOzB3OUW0OS=>
U87MG M2\1VGN6fG:2b4jpZ{BCe3OjeR?= NGD4Spo4OiCq MkDYTWM2OD15Lke3JO69VQ>? MWCyN|A2QTV2NR?=
HBC4 NIP1RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LEVoxw\0eLNUC9MVYvODNiTR?= NYPENXB{OjJ|M{[yOFY>
BSY1 M{D0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2izcYxw\0eLNUC9MVYvQTBiTR?= NWrHNpR[OjJ|M{[yOFY>
HBC5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrScI9oT0l3ME2tOk43OCCP Mn35NlI{OzZ{NE[=
MCF7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH6VWFtd2eJSUWwQU04NjN|IF2= NYrrS3RtOjJ|M{[yOFY>
MDA-MB-231 M4W4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\RVY5xdG:pR1m1NF0uPS52NjDN M4W1clIzOzN4MkS2
U251 NXe2SolGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PrToxw\0eLNUC9MVUvPTBiTR?= NXj2RYhYOjJ|M{[yOFY>
SF268 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDvZnVudG:pR1m1NF0uPS5|OTDN NFXxdoozOjN|NkK0Oi=>
SF295 M4TnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojVcI9oT0l3ME2tOk4{PyCP MknsNlI{OzZ{NE[=
SF539 NYm1ZYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofNcI9oT0l3ME2tOk42OCCP MmfrNlI{OzZ{NE[=
SNB75 M{Hvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jsSIxw\0eLNUC9MVcvOTBiTR?= MYOyNlM{PjJ2Nh?=
SNB78 NITB[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjsc4dIUTVyPT22MlUzKE1? MnHkNlI{OzZ{NE[=
HCC2998 M4LJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljJcI9oT0l3ME2tOk4zQSCP M4nm[FIzOzN4MkS2
KM12 NXzqeYw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFcI9oT0l3ME2tOU44PiCP NHPvbFgzOjN|NkK0Oi=>
HT-29 NGHEco1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPTW4xtd2eJSUWwQU03NjNyIF2= NFzlSYczOjN|NkK0Oi=>
HCT15 NF7reG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\Wd3Btd2eJSUWwQU03NjF{IF2= MVSyNlM{PjJ2Nh?=
HCT116 NH;Le|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlGzcI9oT0l3ME2tOU45PyCP Mn;aNlI{OzZ{NE[=
NCI-H23 NVHINYRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL0cnI{dG:pR1m1NF0uPS55MzDN MYCyNlM{PjJ2Nh?=
NCI-H226 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe2XoFtd2eJSUWwQU03NjJzIF2= NXfvVFRSOjJ|M{[yOFY>
NCI-H522 NUX6OmRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrPcI9oT0l3ME2tOk42QCCP Mk\oNlI{OzZ{NE[=
NCI-H483 M4LKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzsc4dIUTVyPT22MlU3KE1? NVPhW5dVOjJ|M{[yOFY>
A549 NIHqe4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXKNlZQdG:pR1m1NF0uPi5zNTDN MofFNlI{OzZ{NE[=
DMS273 NEX1c|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GyNYxw\0eLNUC9MVYvPDNiTR?= MkHUNlI{OzZ{NE[=
DMS114 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\tdIxw\0eLNUC9MVUvQTJiTR?= MmG2NlI{OzZ{NE[=
LOXIMVI M3;q[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLxboRtd2eJSUWwQU03NjJ7IF2= M3Lyb|IzOzN4MkS2
OVCAR3 NXnGVmc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCVW9TdG:pR1m1NF0uPi55MTDN NFz2[ZMzOjN|NkK0Oi=>
OVCAR4 M4Dyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPLfIZtd2eJSUWwQU02Njd4IF2= NHm1eVAzOjN|NkK0Oi=>
OVCAR5 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nNXYxw\0eLNUC9MVYvOjZiTR?= M3TqVVIzOzN4MkS2
OVCAR8 M{T3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj4cI9oT0l3ME2tOU44OyCP M{HONVIzOzN4MkS2
SKOV3 NX7zc3p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrjXFNtd2eJSUWwQU03NjV{IF2= MU[yNlM{PjJ2Nh?=
RXF631L NGTZcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPsc4dIUTVyPT22Mlg5KE1? NG\Db5ozOjN|NkK0Oi=>
ACHN NXXFbmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q5S4xw\0eLNUC9MVYvODdiTR?= NUO4V4g6OjJ|M{[yOFY>
St-4 NHnMOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HRXIxw\0eLNUC9MVUvPTZiTR?= NEKxXXczOjN|NkK0Oi=>
MKN1 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPsc4dIUTVyPT23MlA5KE1? M3rr[VIzOzN4MkS2
MKN7 M3fXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK0dogydG:pR1m1NF0uPi53MDDN MojLNlI{OzZ{NE[=
MKN28 M1TISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTBRmFsdG:pR1m1NF0uPS53MjDN MXKyNlM{PjJ2Nh?=
MKN45 NGjUSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7sc4dIUTVyPT22MlU2KE1? M4Xyd|IzOzN4MkS2
MKN74 NUPHSmd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLsc4dIUTVyPT22MlAzKE1? NFfjO4szOjN|NkK0Oi=>
DU145 M{HVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHZcI9oT0l3ME2tOU45PSCP MWGyNlM{PjJ2Nh?=
PC3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3lNlRtd2eJSUWwQU03NjZ4IF2= NXPWOWVWOjJ|M{[yOFY>
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HAL-01 NXnHcZNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGroNIZKSzVyPUKwOk44OyCwTR?= M{\wTHNCVkeHUh?=
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NCI-H1623 NE\oOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP3U5NIUUN3ME2zNFQvODhibl2= NGrw[4hUSU6JRWK=
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GAMG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofuTWM2OD1|N{CuPFUhdk1? MUfTRW5ITVJ?
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MDA-MB-361 NEHndXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HjUmlEPTB;NEO5MlE{KG6P M{DRO3NCVkeHUh?=
LXF-289 Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK4XVJqUUN3ME20OFgvOjdibl2= M1fmSXNCVkeHUh?=
NBsusSR NXnSXnhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPLSI92UUN3ME20PFgvQDVibl2= NIDBZnNUSU6JRWK=
KU-19-19 NGLlPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor2TWM2OD13MU[uNFchdk1? NF7rdIhUSU6JRWK=
A204 M3rs[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPYOZFKSzVyPUWyNk4{OyCwTR?= MY\TRW5ITVJ?
LB1047-RCC NEDTS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX75fph5UUN3ME21NlIvQTNibl2= MkHvV2FPT0WU
COLO-684 M4HrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWru[2xRUUN3ME21NlMvOTFibl2= MYXTRW5ITVJ?
PA-1 NIrIVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPtNYQ{UUN3ME21N|IvPDFibl2= M{XuR3NCVkeHUh?=
MG-63 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS5TllKSzVyPUW0NU4yOSCwTR?= M4rtfXNCVkeHUh?=
BHT-101 NFfqTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTqSmZvUUN3ME21OFQvQTRibl2= M2Hh[XNCVkeHUh?=
NKM-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHtTWM2OD13OUOuNFkhdk1? NYjYellpW0GQR1XS
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MOLT-4 MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\4VolKSzVyPU[yN{43OiCwTR?= M2OzUHNCVkeHUh?=
IGROV-1 Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTZ|ND6zNUBvVQ>? NUGxTFk4W0GQR1XS
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HuO-3N1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPtenBKSzVyPU[0Nk4{QCCwTR?= MXHTRW5ITVJ?
NEC8 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXsTWM2OD14NUOuOVchdk1? NITKUmhUSU6JRWK=
HO-1-N-1 NGjOPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLVbYlkUUN3ME22OVkvOTdibl2= MmTCV2FPT0WU
EPCL-272H NWXZXoJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jFVWlEPTB;Nki3MlIyKG6P MXjTRW5ITVJ?
D-263MG NEfEU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TzeGlEPTB;N{G4MlEhdk1? NGf4OoxUSU6JRWK=
MV-4-11 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVXWxJUUN3ME23NlQvOzFibl2= NIjFd5VUSU6JRWK=
SK-NEP-1 NFXRbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPnenNVUUN3ME23NlUvQTRibl2= NFfKUI9USU6JRWK=
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OMC-1 M4j3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXLdmNQUUN3ME23OVEvODlibl2= NXfCPZIyW0GQR1XS
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L-363 M1rnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTd7OD60NkBvVQ>? M1rZUHNCVkeHUh?=
ES8 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\sTXA5UUN3ME24NVAvPTJibl2= NVf5emYxW0GQR1XS
697 M4LyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\hPGNWUUN3ME24N|EvPTVibl2= NET1TpdUSU6JRWK=
HSC-3 M1XRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHVTWM2OD16M{muOVQhdk1? MmfyV2FPT0WU
H4 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GZXNuUUN3ME24OVAvQDVibl2= M1fTT3NCVkeHUh?=
QIMR-WIL NETqR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonlTWM2OD16NkWuNkBvVQ>? NEH5dW9USU6JRWK=
OAW-42 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HPd2lEPTB;OEeyMlE6KG6P MkPQV2FPT0WU
MCF7 NHrpNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3OTWM2OD16OUiuOVkhdk1? MU\TRW5ITVJ?
SCC-25 M4Lw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jtU2lEPTB;OUG0MlE6KG6P MWHTRW5ITVJ?
NCI-H1563 M3\ndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfqTWM2OD17MUWuPVkhdk1? NXW3OmlXW0GQR1XS
OVCAR-5 NGnhRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTl2MD6xO{BvVQ>? NFzVVGxUSU6JRWK=
HDLM-2 M3nOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqxNlVCUUN3ME25OFkvOiCwTR?= M{TmN3NCVkeHUh?=
NB5 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rzfWlEPTB;OUW2MlYhdk1? MmfMV2FPT0WU
NCI-H292 M3LieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3U[JlKSzVyPUm3OE4{OiCwTR?= M{nOT3NCVkeHUh?=
A101D NGrXWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\GNIFKSzVyPUm5NE4yQSCwTR?= M2PlVHNCVkeHUh?=
NCI-H1648 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:4OZRGUUN3ME25PVgvPTFibl2= NVXRUodpW0GQR1XS
EKVX MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV35NpJnUUN3ME2xMlAyOjlizszN M3PRSHNCVkeHUh?=
SW1710 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;BSoNQUUN3ME2xMlA1OjN|IN88US=> M2PkNHNCVkeHUh?=
WM-115 NV\tZXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXzTWM2OD1zLkC2OlU3KM7:TR?= MlmwV2FPT0WU
CAL-54 NYLtRXJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL6eYZPUUN3ME2xMlA4ODhzIN88US=> Mnr0V2FPT0WU
TGBC24TKB M4PSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTOTWM2OD1zLkC4NFQ2KM7:TR?= NVzicWNSW0GQR1XS
NCI-H520 NXnwT|JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HZTWlEPTB;MT6wPFk3PyEQvF2= NHztbY1USU6JRWK=
D-423MG NVX4[GRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwMEm5OlIh|ryP NXP4OnB1W0GQR1XS
BFTC-905 NXPUcopOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXftZXJPUUN3ME2xMlE{PDR7IN88US=> MVvTRW5ITVJ?
HT MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHNTmsxUUN3ME2xMlE{PDd6IN88US=> NIjIdmpUSU6JRWK=
CTB-1 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K4ZmlEPTB;MT6xOFI6OyEQvF2= NGPnOpZUSU6JRWK=
Hs-578-T MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfhU5hJUUN3ME2xMlE6PTZ3IN88US=> MlflV2FPT0WU
HuH-7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz5W|U3UUN3ME2xMlIxQTR7IN88US=> M{O2ZnNCVkeHUh?=
LB996-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XUXmlEPTB;MT6yNlE4PyEQvF2= MXjTRW5ITVJ?
KYSE-270 NHfm[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLTTWM2OD1zLkK5O|M1KM7:TR?= MVrTRW5ITVJ?
A4-Fuk MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwMkm5PVMh|ryP MnntV2FPT0WU
A498 NFrwPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwM{C0O|Qh|ryP M2XMdnNCVkeHUh?=
SK-MEL-1 NXzWNZJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSyc3FSUUN3ME2xMlMxPjd7IN88US=> NVe2OFljW0GQR1XS
AU565 M3XwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33rcWlEPTB;MT6zNVg3OyEQvF2= NEC0SG1USU6JRWK=
Saos-2 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnzdFJKSzVyPUGuN|MzODVizszN Mnv5V2FPT0WU
A549 M2LDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rpVWlEPTB;MT6zPVk4KM7:TR?= MYjTRW5ITVJ?
BFTC-909 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrtPW1KSzVyPUGuOFM{ODVizszN MX7TRW5ITVJ?
MDA-MB-415 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\oOFhoUUN3ME2xMlQ5Pjl{IN88US=> Mn35V2FPT0WU
639-V MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7rOYpKSzVyPUGuOVAzPDVizszN MUDTRW5ITVJ?
A704 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny5TWM2OD1zLkWwO|g2KM7:TR?= MnTuV2FPT0WU
PANC-03-27 M4ezOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzBb4NKSzVyPUGuOVE1ODhizszN M3rtdXNCVkeHUh?=
SK-MEL-28 NVzkcZFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNU[wPFUh|ryP NEj6SWtUSU6JRWK=
Ramos-2G6-4C10 NFXhfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXocWxKSzVyPUGuOlA4PDZizszN NGr0NG5USU6JRWK=
HuP-T4 M1LmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\rRm1KSzVyPUGuOlA4PzhizszN M{izSnNCVkeHUh?=
VA-ES-BJ NXTwVFlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwNkGyO{DPxE1? NI\ocmxUSU6JRWK=
EFM-19 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\2R|ZKSzVyPUGuOlE5OSEQvF2= MUXTRW5ITVJ?
G-401 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrVTWM2OD1zLk[yNVY1KM7:TR?= NYfZRWFTW0GQR1XS
D-566MG NUPocId1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHjTFhKSzVyPUGuOlI2OyEQvF2= MofGV2FPT0WU
JVM-3 MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\Wd3pKSzVyPUGuOlQ5PzVizszN MXvTRW5ITVJ?
TK10 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j4eWlEPTB;MT62O|A5OyEQvF2= MUPTRW5ITVJ?
BT-20 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHtZlRxUUN3ME2xMlY5QTB{IN88US=> NFqxUItUSU6JRWK=
EGI-1 NV;5RYhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzFTWM2OD1zLki0O|AyKM7:TR?= MYDTRW5ITVJ?
EW-16 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nYdmlEPTB;MT64OVE5OiEQvF2= M4ezbXNCVkeHUh?=
NCI-H2228 NWjpXmxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHCN4tTUUN3ME2xMlg2OjB|IN88US=> MlXoV2FPT0WU
BB49-HNC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTwb|JKSzVyPUGuPFg3QTJizszN MVzTRW5ITVJ?
G-402 NFTJXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ITWM2OD1zLki5O|k4KM7:TR?= MYrTRW5ITVJ?
NCI-H526 M2\3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PaXWlEPTB;MT65NVM6KM7:TR?= M4\IenNCVkeHUh?=
ME-180 NUGx[XJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DTUWlEPTB;MT65N|Q4PyEQvF2= NX\HZZZsW0GQR1XS
PFSK-1 NISzdpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnyV3MzUUN3ME2xMlk1PDV6IN88US=> NHzNRoNUSU6JRWK=
TYK-nu M4jSR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7kT|lKSzVyPUGuPVU5OjNizszN MUPTRW5ITVJ?
HOS M2WzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\kVmlEPTB;MT65O|k1QCEQvF2= MXnTRW5ITVJ?
T98G MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwOUmwNFYh|ryP NFTwSYZUSU6JRWK=
SK-MES-1 NWrCUI1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPaTWM2OD1{LkCxN|MzKM7:TR?= M4nBTXNCVkeHUh?=
SNB75 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjtZYdjUUN3ME2yMlAyPTRzIN88US=> MYfTRW5ITVJ?
LAMA-84 NY[1[nUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG3TWM2OD1{LkCyOlg6KM7:TR?= M3eyR3NCVkeHUh?=
CAL-39 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJwMEOyPEDPxE1? NYH3cGVLW0GQR1XS
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NH-12 NGHvbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDJOGhKSzVyPUKuNFU1OjRizszN MkTaV2FPT0WU
NCI-H1048 M3\BeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLDPWw2UUN3ME2yMlExPTJizszN NHf2O4JUSU6JRWK=
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NCI-N87 NUXONZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTQTWM2OD1{LkGzN|g1KM7:TR?= MkXnV2FPT0WU
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NCI-H1650 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki1TWM2OD1{Mz65NlQyKM7:TR?= NHXmRVVUSU6JRWK=
ACHN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG2SIRzUUN3ME2yOE41PjV4IN88US=> M{L6bXNCVkeHUh?=
M059J MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJ2LkW2N|Qh|ryP MnP3V2FPT0WU
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KG-1 M{C0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXaVndKSzVyPUK1MlU1QTRizszN MmC1V2FPT0WU
COLO-824 NUjzeZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHqTWM2OD1{NT61OVk6KM7:TR?= MYjTRW5ITVJ?
NCI-H1155 NIr4[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ3LkW4OFch|ryP NUjvOXdSW0GQR1XS
NCI-H441 M3TFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrHTWM2OD1{NT63OFY2KM7:TR?= MmrxV2FPT0WU
J-RT3-T3-5 NH\EbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKySWx6UUN3ME2yOk4{ODJ5IN88US=> NU\hOHlCW0GQR1XS
JEG-3 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjj[ZNOUUN3ME2yOk43QDB3IN88US=> MXnTRW5ITVJ?
RKO Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ4Lke2N|Ih|ryP MmLFV2FPT0WU
CAL-85-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e1OGlEPTB;MkeuNlEyQCEQvF2= MlnIV2FPT0WU
CAL-120 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXIOphLUUN3ME2yO{43QTF2IN88US=> Mnm5V2FPT0WU
NCI-H2452 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jaNWlEPTB;MkeuO|cyPiEQvF2= MYHTRW5ITVJ?
NCI-H1395 M1PZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHpTWM2OD1{Nz63PFM{KM7:TR?= MmnhV2FPT0WU
KYSE-450 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrFTWM2OD1{Nz65PFYzKM7:TR?= NEHOV4ZUSU6JRWK=
S-117 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LkTGlEPTB;MkmuN|g2PyEQvF2= MX7TRW5ITVJ?
SW13 NHjYeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjKTWM2OD1{OT64OVE6KM7:TR?= M4[2fnNCVkeHUh?=
ES3 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljmTWM2OD1|MD6zO|M{KM7:TR?= MWrTRW5ITVJ?
HCT-116 M3fSZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\zTWM2OD1|MD61OVU1KM7:TR?= NFn3OY1USU6JRWK=
NCI-H1693 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTNyLkW5OFIh|ryP NXvndW8{W0GQR1XS
VM-CUB-1 M{Dn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HL[mlEPTB;M{CuOlQyOyEQvF2= Mm\tV2FPT0WU
NCI-H2170 NFPnVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOyfZNKSzVyPUOxMlU4QDRizszN NYPCb4JqW0GQR1XS
ALL-PO MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jpU2lEPTB;M{GuPFQzQCEQvF2= M2Xo[3NCVkeHUh?=
NCI-H661 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3pUJdjUUN3ME2zNk4xPjJ|IN88US=> MWfTRW5ITVJ?
NCI-H2347 MoTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TvS2lEPTB;M{KuOFg{PyEQvF2= MnXEV2FPT0WU
FTC-133 NIjiTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XkdWlEPTB;M{KuO|A3KM7:TR?= NIDoSYRUSU6JRWK=
COLO-829 MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m0T2lEPTB;M{OuN|Q3PyEQvF2= NGT0V5RUSU6JRWK=
GOTO NYf2UlhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN|LkWyOVgh|ryP MnSwV2FPT0WU
YAPC M1TWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLm[Xg3UUN3ME2zN{45OTV7IN88US=> MkjJV2FPT0WU
LCLC-103H NXjYfW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fnOGlEPTB;M{SuNVYzPCEQvF2= MX;TRW5ITVJ?
SiHa NWH3T|hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH76[WdKSzVyPUO0MlM5OTdizszN NHi1OIxUSU6JRWK=
LK-2 NXrwc5dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDIcZhKSzVyPUO0MlU4ODhizszN M{fiZXNCVkeHUh?=
KP-N-YS M2PKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTN2LkeyNFIh|ryP NWj2bmNjW0GQR1XS
NCI-SNU-1 NWTxWYlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\OTWM2OD1|NT6xO|kh|ryP M4nQZnNCVkeHUh?=
KNS-81-FD NFTGSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\oTXpkUUN3ME2zOU43PjNizszN NUKzR5dJW0GQR1XS
SCC-9 M{LsSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSyN|ZMUUN3ME2zOk44OTR4IN88US=> MWfTRW5ITVJ?
SH-4 M3HVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vWUmlEPTB;M{[uO|Mh|ryP MojwV2FPT0WU
HCC-1954 M{X2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLVPHdRUUN3ME2zO{4zPzJ7IN88US=> MX;TRW5ITVJ?
BALL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH5PZhKSzVyPUO3MlU{OTZizszN NEG1VXNUSU6JRWK=
BE-13 M4LDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7oTWM2OD1|Nz63NFE5KM7:TR?= NGnWb3hUSU6JRWK=
COLO-678 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TpZmlEPTB;M{euPVQ{PyEQvF2= MlTXV2FPT0WU
SK-MEL-3 M1q5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\xTGl5UUN3ME2zPE4zOzl5IN88US=> M4ixXXNCVkeHUh?=
OAW-28 M1;ZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN6Lk[zPUDPxE1? MUjTRW5ITVJ?
CAMA-1 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXKyR5RTUUN3ME2zPE46PjlzIN88US=> MUTTRW5ITVJ?
C2BBe1 M{nFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTwTWM2OD1|OT64NVgh|ryP NHW4cppUSU6JRWK=
A3-KAW MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzadm1xUUN3ME20NE4{PjZzIN88US=> Ml7rV2FPT0WU
SK-MEL-24 NG\RSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRyLkW5N|Eh|ryP NFXVOZRUSU6JRWK=
KYSE-140 M3\Dcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXpSJN5UUN3ME20NE44OTZ3IN88US=> MoHMV2FPT0WU
MOLT-16 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;hTWM2OD12MT6xOVM3KM7:TR?= NHzERWhUSU6JRWK=
CFPAC-1 M1nNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\3bZR7UUN3ME20Nk42OjFzIN88US=> NWHaT4FMW0GQR1XS
NB14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\4TWM2OD12Mj63NFI4KM7:TR?= M2PiZnNCVkeHUh?=
COLO-792 M2rBdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTR{Lki5OlEh|ryP NVTiZWY6W0GQR1XS
RH-1 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7WZnA6UUN3ME20N{41QDN4IN88US=> MYDTRW5ITVJ?
NCI-H522 NVOxenA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjyTWM2OD12ND6zOVY5KM7:TR?= M1zXS3NCVkeHUh?=
Ca-Ski MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fJOmlEPTB;NESuPFEyPCEQvF2= NEj3d5hUSU6JRWK=
KGN NV7XbJlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYmxR49sUUN3ME20PE4{ODZ|IN88US=> M1\1WHNCVkeHUh?=
UACC-62 NYS1OnRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGm4VlZKSzVyPUS4MlQxPzJizszN MoLBV2FPT0WU
NCI-H358 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj0TpdKSzVyPUS5MlMxOThizszN MlzkV2FPT0WU
LS-411N NUXJUZduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\yfpp5UUN3ME20PU4{OTF6IN88US=> NGPFXoVUSU6JRWK=
IST-MES1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLSTWM2OD12OT61OlI2KM7:TR?= NHjGXnJUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1
NCT00999128 Completed Drug: GDC-0941|Drug: rabeprazole Healthy Volunteers Genentech Inc. October 26 2009 Phase 1
NCT00975182 Completed Drug: GDC-0941|Drug: erlotinib HCl Non-Squamous Non-Small Cell Lung Cancer Solid Cancers Genentech Inc. September 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID