Pictilisib (GDC-0941)

For research use only.

Catalog No.S1065 Synonyms: RG7321

303 publications

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.

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Selleck's Pictilisib (GDC-0941) has been cited by 303 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NY\USGxCU2mwYYPlJGF{e2G7 NXvNVVRQOSCq NXq0OIxGTE2VTx?= M3jDeWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyZHXseIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFA{KM7:TR?= NF\DXpAyQDd3NE[1OC=>
Sf9 NXe2NVk4U2mwYYPlJGF{e2G7 MX2xJIg> NVrFemxqTE2VTx?= NXjUbWNrUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEhzMES3MXIhdXW2YX70JIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? M4HKT|E5PzV2NkW0
Sf9 NF7xd|hMcW6jc3WgRZN{[Xl? MYexJIg> MYXEUXNQ M1XPcGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> NWjENndvOTh5NUS2OVQ>
Sf9 MlmyT4lv[XOnIFHzd4F6 M37mcFEhcA>? M4\lcWROW09? NUjGNY84UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= MWGxPFc2PDZ3NB?=
Sf9 NFm5W|VMcW6jc3WgRZN{[Xl? M3zVTlEhcA>? MmLESG1UVw>? NGfiVlRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHHsdIhiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhi MYGxPFc2PDZ3NB?=
MDA-MB-361 NUHPToZsTnWwY4Tpc44hSXO|YYm= NYLpSJRIOiCq Mn74SG1UVw>? MXXJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NUHhcGZVOTh5NUS2OVQ>
PC3 M3m1PGZ2dmO2aX;uJGF{e2G7 NYfqfJRXOiCq M{e4b2ROW09? NVrlV5BLUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? MmPkNVg4PTR4NUS=
U87MG NXTSVXN4TnWwY4Tpc44hSXO|YYm= MWKyJIg> NV\pOop[TE2VTx?= NYLDfmJQUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gWVg4VUdiY3XscJMhf2m2aDDJR|UxKG:oIECuNFQ3KM7:TR?= NEnyfJQyQDd3NE[1OC=>
MDA-MB-361 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfUPVYhcA>? MnnQSG1UVw>? MmjCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE44OiEQvF2= M4joVVE5PzV2NkW0
A2780 NYeyeYRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjXPVYhcA>? Mor1SG1UVw>? MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IIfpeIghWEmNM1PBJIFv\CCSVFXOJI12fGG2aX;uJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? MoDjNVg4PTR4NUS=
PC3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnLPI9HQTZiaB?= M2LWSWROW09? MWXJR|UxRTBwMkig{txO MoHwNVg4PTR4NUS=
U87MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOPJg6PiCq NVLOXWxqTE2VTx?= NE\UPZpKSzVyPUCuPVUh|ryP NWq1XGJ[OTh5NUS2OVQ>
Sf9 NUDnSZdIU2mwYYPlJGF{e2G7 MoLJN|AhdWmw NIjafmlFVVOR NXjmRVNzUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIFud3WwdDDv[kBCXFBiY3;ud5Vu\WRid3n0bEBKSzVyIH;mJFAvODR{IN88US=> M33RSlIzPTR6M{Sy
RAW 264.7 M1jET2tqdmG|ZTDBd5NigQ>? MmLCPVAhdWmw M{n2dmROW09? NHrQcoFKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> NULGUGs{OjJ3NEizOFI>
Sf9 NHPkSlNMcW6jc3WgRZN{[Xl? M3T5dVEhcA>? NX3STVE{UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO M{XrUFI{PTRyNkS1
Sf9 NX;5Umw1U2mwYYPlJGF{e2G7 NHKyNlcyKGh? MVrJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm NGjZZoEzOzV2ME[0OS=>
Sf9 M3Oz[mtqdmG|ZTDBd5NigQ>? NGnrXlkyKGh? NWPDUYM{UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> MV:yN|U1ODZ2NR?=
Sf9 NYLZRZY4U2mwYYPlJGF{e2G7 M4[3c|EhcA>? M3jKe2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= M164clI{PTRyNkS1
SKOV3 M3jIR2tqdmG|ZTDBd5NigQ>? NIPrdZQyKM7:TR?= NW\ZPWNuOSCq NV\3dos6TE2VTx?= NWqxdZJZUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= MV6yN|M3ODN2OB?=
MCF7 M3rlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ZRWZlOSEQvF2= M2\Eflk3KGh? M3fMPWROW09? MnnaS2k2OD1yLkC3NFIh|ryP M2SxclI{OzZyM{S4
SKOV3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:xJO69VQ>? NIfJSmc6PiCq NEPyUZRFVVOR MYfHTVUxRTBwMUS3OkDPxE1? M3LYVlI{OzZyM{S4
PC3 NXjKfnNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;ndHVOPzJiaB?= M4HuUWROW09? MkH4TWM2OD1yLkK4JO69VQ>? M4LNbFIyQThzN{G0
MCF7.1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j3NVczKGh? MV3EUXNQ MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJGhGWjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MkmxNlE6QDF5MUS=
MCF7-neo/Her2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXi3NkBp MXPEUXNQ MkGwTWM2OD1yLkK5JO69VQ>? NU\vOWRMOjN4NkK5NFM>
MCF7-neo/Her2 MUjLbY5ie2ViQYPzZZk> MWjJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KHerdHigTWM2OCCxZjCwMlAxPyEQvF2= MVqyN|Y3OjlyMx?=
PC3 NH:yfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17nPFczKGh? MY\EUXNQ NXzGOpRqTUN3ME2wMlM1KM7:TR?= NXX2OINqOjF7OEW2N|k>
MCF7.1 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHNPYw4OiCq MXXEUXNQ NXr6fWQ5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigSWM2OCCxZjCwMlM6KM7:TR?= Mme1NlE6QDV4M{m=
PC3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr1V|NFPzJiaB?= NELqRZRFVVOR M1P5NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHTl[olkcWWwdDDpckBRXEWQIIfpeIghUUN3MDDv[kAxNjN7IN88US=> M{foNVIxODVyNk[5
MCF7.1 NXfyOWVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYG3NkBp NEHP[5VFVVOR MlP0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? NXzpUGlmOjByNUC2Olk>
MCF7.1 M3fXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHn[Hk{PzJiaB?= MWHFR|UxRTBwN{Kg{txO MW[yNFM1PjZ3Nh?=
NCI-H1975 MkDUR5l1d3SxeHnjJGF{e2G7 MWm3NkBp MUDJR|UxRTBwMkeg{txO MX[yN|A2QTV2NR?=
H460 MlOzR5l1d3SxeHnjJGF{e2G7 M3i4SlczKGh? MX\JR|UxRTBwOEeg{txO NGm3UI0zOzB3OUW0OS=>
HT-29 MoTwR5l1d3SxeHnjJGF{e2G7 NXTmfYx6PzJiaB?= M3zkcmlEPTB;MD62OkDPxE1? MonuNlMxPTl3NEW=
HepG2 NV3afIJoS3m2b4TvfIlkKEG|c3H5 NXm1Z|lTPzJiaB?= MlLBTWM2OD1zIN88US=> NH\1VXkzOzB3OUW0OS=>
SGC7901 MYLDfZRwfG:6aXOgRZN{[Xl? MkHCO|IhcA>? NVP4RlVtUUN3ME2xMlgh|ryP M1rOXFI{ODV7NUS1
NCI-H226 MlTQR5l1d3SxeHnjJGF{e2G7 MnHTO|IhcA>? NFTrdGhKSzVyPUKuPUDPxE1? M{O1R|I{ODV7NUS1
A549 NVzwcZBNS3m2b4TvfIlkKEG|c3H5 NFLV[lA4OiCq MkPuTWM2OD14Lkmg{txO M4XBb|I{ODV7NUS1
U87MG M1\VSGN6fG:2b4jpZ{BCe3OjeR?= NGnNeYc4OiCq Mnj5TWM2OD15Lke3JO69VQ>? Mn7mNlMxPTl3NEW=
HBC4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vOTYxw\0eLNUC9MVYvODNiTR?= NIjYdWszOjN|NkK0Oi=>
BSY1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXte5dtd2eJSUWwQU03NjlyIF2= M1XjTFIzOzN4MkS2
HBC5 NIrtN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rLcoxw\0eLNUC9MVYvPjBiTR?= MXmyNlM{PjJ2Nh?=
MCF7 M3W0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HzO4xw\0eLNUC9MVcvOzNiTR?= M4DaOFIzOzN4MkS2
MDA-MB-231 M{CzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTsc4dIUTVyPT21MlQ3KE1? NHHmS5AzOjN|NkK0Oi=>
U251 MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvsc4dIUTVyPT21MlUxKE1? MVeyNlM{PjJ2Nh?=
SF268 M3;1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfsc4dIUTVyPT21MlM6KE1? M3HmUVIzOzN4MkS2
SF295 NUSxTGc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi0[XJtd2eJSUWwQU03NjN5IF2= NU\lV2ZNOjJ|M{[yOFY>
SF539 NH\UfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnYcI9oT0l3ME2tOk42OCCP NFfHN4ozOjN|NkK0Oi=>
SNB75 NHr6OJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TIO4xw\0eLNUC9MVcvOTBiTR?= NEK2O4czOjN|NkK0Oi=>
SNB78 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXsc4dIUTVyPT22MlUzKE1? NF3YeFczOjN|NkK0Oi=>
HCC2998 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PUU4xw\0eLNUC9MVYvOjliTR?= Ml7mNlI{OzZ{NE[=
KM12 NG[3RlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHsc4dIUTVyPT21Mlc3KE1? NXnxNWxMOjJ|M{[yOFY>
HT-29 M2rCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\acI9oT0l3ME2tOk4{OCCP Ml7qNlI{OzZ{NE[=
HCT15 NGG0emRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[yRZQ2dG:pR1m1NF0uPi5zMjDN NY[3OZg5OjJ|M{[yOFY>
HCT116 NHfBbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD6cI9oT0l3ME2tOU45PyCP NH\EZ3AzOjN|NkK0Oi=>
NCI-H23 NFzLPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPkcI9oT0l3ME2tOU44OyCP Mnz6NlI{OzZ{NE[=
NCI-H226 M3PYRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH6NlZVdG:pR1m1NF0uPi5{MTDN NIizeZQzOjN|NkK0Oi=>
NCI-H522 M3W4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofEcI9oT0l3ME2tOk42QCCP NHvEWIczOjN|NkK0Oi=>
NCI-H483 NVnlcYY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHicI9oT0l3ME2tOk42PiCP MXOyNlM{PjJ2Nh?=
A549 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT5cI9oT0l3ME2tOk4yPSCP MWeyNlM{PjJ2Nh?=
DMS273 NVXRW4RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WxW4xw\0eLNUC9MVYvPDNiTR?= MnfSNlI{OzZ{NE[=
DMS114 M4n4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjsc4dIUTVyPT21MlkzKE1? NFPkUXgzOjN|NkK0Oi=>
LOXIMVI NVi2UFBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3izeoxw\0eLNUC9MVYvOjliTR?= NX7qUZBYOjJ|M{[yOFY>
OVCAR3 NXXCbVdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPZS4VvdG:pR1m1NF0uPi55MTDN NXXmdGUzOjJ|M{[yOFY>
OVCAR4 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLWcI9oT0l3ME2tOU44PiCP NIPOc4czOjN|NkK0Oi=>
OVCAR5 M3rqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPqTZk3dG:pR1m1NF0uPi5{NjDN NVfqXXVSOjJ|M{[yOFY>
OVCAR8 NULmOnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\WSYRRdG:pR1m1NF0uPS55MzDN MlTDNlI{OzZ{NE[=
SKOV3 NV7reYJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjsc4dIUTVyPT22MlUzKE1? MXGyNlM{PjJ2Nh?=
RXF631L M4LCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPsc4dIUTVyPT22Mlg5KE1? NGnVXlQzOjN|NkK0Oi=>
ACHN MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HFWIxw\0eLNUC9MVYvODdiTR?= M13BPFIzOzN4MkS2
St-4 NGjRVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLPcI9oT0l3ME2tOU42PiCP M331XVIzOzN4MkS2
MKN1 M1HTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTsc4dIUTVyPT23MlA5KE1? Mn[zNlI{OzZ{NE[=
MKN7 NFjTOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnSd5Ftd2eJSUWwQU03NjVyIF2= NVrub49rOjJ|M{[yOFY>
MKN28 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7WSHBtd2eJSUWwQU02NjV{IF2= NUHzTml7OjJ|M{[yOFY>
MKN45 NWHMSJZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHZelh1dG:pR1m1NF0uPi53NTDN NGLKWGszOjN|NkK0Oi=>
MKN74 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ywR4xw\0eLNUC9MVYvODJiTR?= NFrWO2ozOjN|NkK0Oi=>
DU145 NEjiWJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3sc4dIUTVyPT21Mlg2KE1? MYKyNlM{PjJ2Nh?=
PC3 NX;CR2VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ZR3Btd2eJSUWwQU03NjZ4IF2= NITSbFUzOjN|NkK0Oi=>
ES5 M2\Xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL4TWM2OD13MD6yNUBvVQ>? Mnz2V2FPT0WU
HH Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjaTWM2OD1zMUGuNFghdk1? NEX3PHpUSU6JRWK=
MHH-PREB-1 NXnQfGdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFzND6zJI5O MYnTRW5ITVJ?
NCI-H1770 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF{Mz64OkBvVQ>? MW\TRW5ITVJ?
HuO9 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonpTWM2OD1{ME[uNFIhdk1? MYTTRW5ITVJ?
HAL-01 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;jSGlEPTB;MkC2Mlc{KG6P MnzhV2FPT0WU
NOS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJzMT64NkBvVQ>? NH3RPXVUSU6JRWK=
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NB69 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\n[WlEPTB;MkS1MlI4KG6P MULTRW5ITVJ?
RS4-11 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ4MT63OkBvVQ>? Mni2V2FPT0WU
DOK MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TROWlEPTB;M{CxMlchdk1? MX3TRW5ITVJ?
LB2241-RCC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXmO5VmUUN3ME2zNFMvQDRibl2= MnzaV2FPT0WU
NCI-H1623 NGPsT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rrbWlEPTB;M{C0MlA5KG6P MUnTRW5ITVJ?
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MDA-MB-175-VII MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnZTWM2OD1|NUKuPVIhdk1? M4XDe3NCVkeHUh?=
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HL-60 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7CTWM2OD12MkWuO|Uhdk1? NXXZRpR3W0GQR1XS
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MDA-MB-361 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLtTWM2OD12M{muNVMhdk1? MVTTRW5ITVJ?
LXF-289 NWnRbWk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHmTWM2OD12NEiuNlchdk1? Mn\mV2FPT0WU
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LB1047-RCC Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvPS4ZKSzVyPUWyNk46OyCwTR?= MUDTRW5ITVJ?
COLO-684 NITzRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzIelNQUUN3ME21NlMvOTFibl2= NF\FfGpUSU6JRWK=
PA-1 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LjT2lEPTB;NUOyMlQyKG6P NIC5SoFUSU6JRWK=
MG-63 M3nIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q4fmlEPTB;NUSxMlEyKG6P MliyV2FPT0WU
BHT-101 NV;hdWJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TZWmlEPTB;NUS0Mlk1KG6P MmXMV2FPT0WU
NKM-1 NHzN[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli5TWM2OD13OUOuNFkhdk1? MmjKV2FPT0WU
T47D MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLLTWM2OD13OUeuOVYhdk1? MmTqV2FPT0WU
MOLT-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV61VXczUUN3ME22NlMvPjJibl2= NGP1[I9USU6JRWK=
IGROV-1 M4XqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\wTWM2OD14M{SuN|Ehdk1? MkDSV2FPT0WU
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HuO-3N1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTZ2Mj6zPEBvVQ>? MnTDV2FPT0WU
NEC8 M3G3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHPOIRKSzVyPU[1N{42PyCwTR?= MWDTRW5ITVJ?
HO-1-N-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTZ3OT6xO{BvVQ>? MXzTRW5ITVJ?
EPCL-272H NV\PZ2pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfQelE6UUN3ME22PFcvOjFibl2= NVLlWoQxW0GQR1XS
D-263MG NYjwXWZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i4SGlEPTB;N{G4MlEhdk1? NVzMNphyW0GQR1XS
MV-4-11 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHDfFFKSzVyPUeyOE4{OSCwTR?= NWfafph{W0GQR1XS
SK-NEP-1 NXf5cYxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPPcGpKSzVyPUeyOU46PCCwTR?= MYPTRW5ITVJ?
SW872 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTd{Nz64PUBvVQ>? NIfQc3VUSU6JRWK=
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OMC-1 NHL1OG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PSfGlEPTB;N{WxMlA6KG6P MoTVV2FPT0WU
LoVo NIezcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vKeGlEPTB;N{e3Mlkhdk1? M3TPUnNCVkeHUh?=
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L-363 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPsd3NKSzVyPUe5PE41OiCwTR?= NVPMb2VTW0GQR1XS
ES8 NFPwNnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Hab2lEPTB;OEGwMlUzKG6P MV;TRW5ITVJ?
697 NXTE[oIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrE[GtKSzVyPUizNU42PSCwTR?= NUnXWVhpW0GQR1XS
HSC-3 M1;pSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO2TWM2OD16M{muOVQhdk1? M1LPeXNCVkeHUh?=
H4 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTLXGVRUUN3ME24OVAvQDVibl2= MX;TRW5ITVJ?
QIMR-WIL M3e5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TVbWlEPTB;OE[1MlIhdk1? NWrrc4tTW0GQR1XS
OAW-42 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHNVoFKSzVyPUi3Nk4yQSCwTR?= MWLTRW5ITVJ?
MCF7 NXrEbWxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTh7OD61PUBvVQ>? NFPXUFhUSU6JRWK=
SCC-25 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjVcGhKSzVyPUmxOE4yQSCwTR?= MVTTRW5ITVJ?
NCI-H1563 NWrRb5oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTlzNT65PUBvVQ>? NFraTI5USU6JRWK=
OVCAR-5 NV;S[mZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTl2MD6xO{BvVQ>? MlXpV2FPT0WU
HDLM-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTl2OT6yJI5O NHfBclNUSU6JRWK=
NB5 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPCTWM2OD17NU[uOkBvVQ>? NFLjXGlUSU6JRWK=
NCI-H292 NWftenB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLxPYJKSzVyPUm3OE4{OiCwTR?= NFnke2NUSU6JRWK=
A101D NF3IUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLyTWM2OD17OUCuNVkhdk1? MULTRW5ITVJ?
NCI-H1648 M3i4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jwPGlEPTB;OUm4MlUyKG6P M3Xsc3NCVkeHUh?=
EKVX M4e2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\UUYxKSzVyPUGuNFEzQSEQvF2= M3PtSHNCVkeHUh?=
SW1710 NUK2OG1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwMESyN|Mh|ryP MUHTRW5ITVJ?
WM-115 M4XEXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHu0SHZKSzVyPUGuNFY3PTZizszN NULNc4lDW0GQR1XS
CAL-54 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\KTWM2OD1zLkC3NFgyKM7:TR?= M3TqNXNCVkeHUh?=
TGBC24TKB MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXQTWM2OD1zLkC4NFQ2KM7:TR?= MmSzV2FPT0WU
NCI-H520 M2DSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDleGxKSzVyPUGuNFg6PjdizszN NIO0dppUSU6JRWK=
D-423MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme0TWM2OD1zLkC5PVYzKM7:TR?= NVrkN|hSW0GQR1XS
BFTC-905 NFyyb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjmeIJKSzVyPUGuNVM1PDlizszN MWTTRW5ITVJ?
HT NIDzSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\j[pRKSzVyPUGuNVM1PzhizszN M1PLUXNCVkeHUh?=
CTB-1 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[xWVZ2UUN3ME2xMlE1Ojl|IN88US=> M{PWSnNCVkeHUh?=
Hs-578-T Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrBN4FKSzVyPUGuNVk2PjVizszN NE\Y[phUSU6JRWK=
HuH-7 NI[1RVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETxcFhKSzVyPUGuNlA6PDlizszN MoTqV2FPT0WU
LB996-RCC M3LFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TjUWlEPTB;MT6yNlE4PyEQvF2= NFz5PWFUSU6JRWK=
KYSE-270 NW[2S2NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz3[mpKSzVyPUGuNlk4OzRizszN M{DE[nNCVkeHUh?=
A4-Fuk M165[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW5T4xKSzVyPUGuNlk6QTNizszN NFXQVY5USU6JRWK=
A498 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwM{C0O|Qh|ryP M1jFWXNCVkeHUh?=
SK-MEL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvIVmVKSzVyPUGuN|A3PzlizszN NIjDWIdUSU6JRWK=
AU565 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXGXXBKSzVyPUGuN|E5PjNizszN NVjQTlFIW0GQR1XS
Saos-2 NECzR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvtb29KSzVyPUGuN|MzODVizszN NWLwO3d2W0GQR1XS
A549 NVrnfoM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwM{m5O{DPxE1? MWXTRW5ITVJ?
BFTC-909 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PmTGlEPTB;MT60N|MxPSEQvF2= MWnTRW5ITVJ?
MDA-MB-415 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nyXWlEPTB;MT60PFY6OiEQvF2= MV\TRW5ITVJ?
639-V NHmzcGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzsS|JWUUN3ME2xMlUxOjR3IN88US=> NH\wOJRUSU6JRWK=
A704 NXXHOIdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwNUC3PFUh|ryP NGXKT2tUSU6JRWK=
PANC-03-27 NES5e4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\jTWM2OD1zLkWxOFA5KM7:TR?= MV7TRW5ITVJ?
SK-MEL-28 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33icGlEPTB;MT61OlA5PSEQvF2= MkfTV2FPT0WU
Ramos-2G6-4C10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi1Z3ZZUUN3ME2xMlYxPzR4IN88US=> NGjYRoNUSU6JRWK=
HuP-T4 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTFwNkC3O|gh|ryP MXXTRW5ITVJ?
VA-ES-BJ MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\oV2lEPTB;MT62NVI4KM7:TR?= MW\TRW5ITVJ?
EFM-19 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33vPWlEPTB;MT62NVgyKM7:TR?= NWXzUpRGW0GQR1XS
G-401 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFwNkKxOlQh|ryP NYjxRo5sW0GQR1XS
D-566MG MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjkTWM2OD1zLk[yOVMh|ryP NH;rcGhUSU6JRWK=
JVM-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwNkS4O|Uh|ryP MoDHV2FPT0WU
TK10 M4rWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPScotKSzVyPUGuOlcxQDNizszN NUfhOG9WW0GQR1XS
BT-20 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrRTWM2OD1zLk[4PVAzKM7:TR?= NVHMdHVyW0GQR1XS
EGI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LR[WlEPTB;MT64OFcxOSEQvF2= NVuzTXJPW0GQR1XS
EW-16 M4LVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XxXmlEPTB;MT64OVE5OiEQvF2= NHfLVnJUSU6JRWK=
NCI-H2228 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPjTWM2OD1zLki1NlA{KM7:TR?= MV;TRW5ITVJ?
BB49-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXqTWM2OD1zLki4OlkzKM7:TR?= NYr6NXFwW0GQR1XS
G-402 M1jscWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[wTWM2OD1zLki5O|k4KM7:TR?= MUnTRW5ITVJ?
NCI-H526 M4TOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3sNHBKSzVyPUGuPVE{QSEQvF2= M{XNZ3NCVkeHUh?=
ME-180 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjCN4I6UUN3ME2xMlk{PDd5IN88US=> M{[2RnNCVkeHUh?=
PFSK-1 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPYWG04UUN3ME2xMlk1PDV6IN88US=> MYfTRW5ITVJ?
TYK-nu NUXaNWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;w[Gl6UUN3ME2xMlk2QDJ|IN88US=> MlTxV2FPT0WU
HOS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFwOUe5OFgh|ryP NIjFcmdUSU6JRWK=
T98G MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GS|ROUUN3ME2xMlk6ODB4IN88US=> MV\TRW5ITVJ?
SK-MES-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwMEGzN|Ih|ryP MX3TRW5ITVJ?
SNB75 NVnvZ4pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHhWo1uUUN3ME2yMlAyPTRzIN88US=> NHi3V|BUSU6JRWK=
LAMA-84 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nmO2lEPTB;Mj6wNlY5QSEQvF2= MV7TRW5ITVJ?
CAL-39 MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJwMEOyPEDPxE1? MUfTRW5ITVJ?
LOXIMVI MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJwMESwPFQh|ryP NH\DcJdUSU6JRWK=
NH-12 M3KwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrCUoNKSzVyPUKuNFU1OjRizszN M4\uU3NCVkeHUh?=
NCI-H1048 M4nFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrDdo5tUUN3ME2yMlExPTJizszN NXfEfVlMW0GQR1XS
KS-1 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXxUo1KSzVyPUKuNVExODFizszN NVvoNpp2W0GQR1XS
NCI-N87 NXLqNFhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M370OGlEPTB;Mj6xN|M5PCEQvF2= NHXvWmZUSU6JRWK=
CHP-212 NHLhVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr4N2NqUUN3ME2yMlE5PDR{IN88US=> NIrWdXRUSU6JRWK=
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NCI-H1650 NWnKR29wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX5TWM2OD1{Mz65NlQyKM7:TR?= Mln4V2FPT0WU
ACHN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XVN2lEPTB;MkSuOFY2PiEQvF2= NHjpU5NUSU6JRWK=
M059J MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X2fmlEPTB;MkSuOVY{PCEQvF2= NHXobpZUSU6JRWK=
AM-38 NVvh[mZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLPTWM2OD1{NT60PFEh|ryP NVHkZW9KW0GQR1XS
KG-1 M1LRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33pO2lEPTB;MkWuOVQ6PCEQvF2= NETLcWVUSU6JRWK=
COLO-824 NGDROHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELyR2FKSzVyPUK1MlU2QTlizszN NFrn[W9USU6JRWK=
NCI-H1155 M17QWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7mTWM2OD1{NT61PFQ4KM7:TR?= MULTRW5ITVJ?
NCI-H441 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjSU2tKSzVyPUK1Mlc1PjVizszN MVjTRW5ITVJ?
J-RT3-T3-5 NXTw[2d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[5[nNKSzVyPUK2MlMxOjdizszN MmjoV2FPT0WU
JEG-3 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJ4Lk[4NFUh|ryP NE\4UoZUSU6JRWK=
RKO Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJ4Lke2N|Ih|ryP MXvTRW5ITVJ?
CAL-85-1 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPLelNKSzVyPUK3MlIyOThizszN MmP5V2FPT0WU
CAL-120 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPSTWM2OD1{Nz62PVE1KM7:TR?= MV3TRW5ITVJ?
NCI-H2452 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfOTWM2OD1{Nz63O|E3KM7:TR?= Mn3YV2FPT0WU
NCI-H1395 NXL1bYdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DRS2lEPTB;MkeuO|g{OyEQvF2= NUe2emVYW0GQR1XS
KYSE-450 M1vzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2yXFIzUUN3ME2yO{46QDZ{IN88US=> MUfTRW5ITVJ?
S-117 NIruboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrzbYRYUUN3ME2yPU4{QDV5IN88US=> NYjReXhVW0GQR1XS
SW13 NIjIdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXj[FJKSzVyPUK5Mlg2OTlizszN NXzwZ5ZpW0GQR1XS
ES3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLxWJlKSzVyPUOwMlM4OzNizszN MY\TRW5ITVJ?
HCT-116 NH3lco1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jObGlEPTB;M{CuOVU2PCEQvF2= NHrXc3NUSU6JRWK=
NCI-H1693 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTNyLkW5OFIh|ryP NY\0e3dkW0GQR1XS
VM-CUB-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDEeoJKSzVyPUOwMlY1OTNizszN MojYV2FPT0WU
NCI-H2170 M3;HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq3[IVKSzVyPUOxMlU4QDRizszN MmjPV2FPT0WU
ALL-PO MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNzLki0Nlgh|ryP M2juOHNCVkeHUh?=
NCI-H661 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL6ZXdKSzVyPUOyMlA3OjNizszN M3fhU3NCVkeHUh?=
NCI-H2347 NIrqb|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm5cY5qUUN3ME2zNk41QDN5IN88US=> NVfVclM2W0GQR1XS
FTC-133 NYHEdWRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Czb2lEPTB;M{KuO|A3KM7:TR?= M17KNXNCVkeHUh?=
COLO-829 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTN|LkO0Olch|ryP MmnGV2FPT0WU
GOTO NFjJNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rRWWlEPTB;M{OuOVI2QCEQvF2= NHHNN3RUSU6JRWK=
YAPC NXfwPJdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn6d3JKSzVyPUOzMlgyPTlizszN NUPCS2dZW0GQR1XS
LCLC-103H MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknMTWM2OD1|ND6xOlI1KM7:TR?= MkPUV2FPT0WU
SiHa MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3cGlEPTB;M{SuN|gyPyEQvF2= M2K5UnNCVkeHUh?=
LK-2 NI[xXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfHfoJKSzVyPUO0MlU4ODhizszN MVTTRW5ITVJ?
KP-N-YS NWTHeIFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTN2LkeyNFIh|ryP MVXTRW5ITVJ?
NCI-SNU-1 NF\MU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q4c2lEPTB;M{WuNVc6KM7:TR?= MnPZV2FPT0WU
KNS-81-FD MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf0coVKSzVyPUO1MlY3OyEQvF2= MX3TRW5ITVJ?
SCC-9 M4G1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvIOmxKSzVyPUO2MlcyPDZizszN NFjHdmtUSU6JRWK=
SH-4 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfnbnNKSzVyPUO2Mlc{KM7:TR?= NWn5S3lyW0GQR1XS
HCC-1954 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn4cohKSzVyPUO3MlI4OjlizszN NXPQSZc4W0GQR1XS
BALL-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN5LkWzNVYh|ryP NHG4VZhUSU6JRWK=
BE-13 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\FeFhKSzVyPUO3MlcxOThizszN M3jIWHNCVkeHUh?=
COLO-678 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN5Lkm0N|ch|ryP M1Hs[nNCVkeHUh?=
SK-MEL-3 M3LIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;W[4ZNUUN3ME2zPE4zOzl5IN88US=> Mlz1V2FPT0WU
OAW-28 NIXr[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHvVotKSzVyPUO4MlY{QSEQvF2= M33pVHNCVkeHUh?=
CAMA-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;CeJMyUUN3ME2zPE46PjlzIN88US=> NIf2NHFUSU6JRWK=
C2BBe1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPGVYdKSzVyPUO5MlgyQCEQvF2= MnnJV2FPT0WU
A3-KAW MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTRyLkO2OlEh|ryP NFzEV4NUSU6JRWK=
SK-MEL-24 NYLIWWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfFTWM2OD12MD61PVMyKM7:TR?= NFL1UZFUSU6JRWK=
KYSE-140 NE\ncllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W0TWlEPTB;NECuO|E3PSEQvF2= NWH1OWxEW0GQR1XS
MOLT-16 M3PIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\hNnRPUUN3ME20NU4yPTN4IN88US=> NWnpfYJqW0GQR1XS
CFPAC-1 Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX6TWM2OD12Mj61NlEyKM7:TR?= MUnTRW5ITVJ?
NB14 M3H1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXmTWM2OD12Mj63NFI4KM7:TR?= M3XQeXNCVkeHUh?=
COLO-792 NHrve3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTR{Lki5OlEh|ryP MUfTRW5ITVJ?
RH-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrvb3pvUUN3ME20N{41QDN4IN88US=> Ml7qV2FPT0WU
NCI-H522 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;1NW5KSzVyPUS0MlM2PjhizszN NFv2SY5USU6JRWK=
Ca-Ski NV;3U25bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPRTWM2OD12ND64NVE1KM7:TR?= Ml\IV2FPT0WU
KGN NFuwV|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fIbGlEPTB;NEiuN|A3OyEQvF2= Mn3GV2FPT0WU
UACC-62 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR6LkSwO|Ih|ryP NUK1T41iW0GQR1XS
NCI-H358 M3ey[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPZcWRmUUN3ME20PU4{ODF6IN88US=> MVHTRW5ITVJ?
LS-411N MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTqXpd1UUN3ME20PU4{OTF6IN88US=> MXLTRW5ITVJ?
IST-MES1 NVrmTJVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLlTWM2OD12OT61OlI2KM7:TR?= MX\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

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Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

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  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321
Smiles C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID