For research use only.
Catalog No.S4505 Synonyms: NSC49842
Molecular Weight(MW): 909.05
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
Selleck's Vinblastine sulfate has been cited by 15 publications
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|Description||Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.|
The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC.
|In vivo||Vinblastine is a widely used anticancer drug with undesired side effects . A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin).|
-  McKay DB, et al. Proc Soc Exp Biol Med. 1993, 203(3):372-376.
-  George E. Johnson, et al. Mutat Res. 2010, 702(2):189-192.
-  Zhou XJ, et al. Eur J Drug Metab Pharmacokinet. 1990, 15(4):323-332.
|In vitro||DMSO||100 mg/mL (110.0 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02840409||Recruiting||Drug: Vinblastine|Drug: Bevacizumab||Low Grade Glioma||The Hospital for Sick Children|Hoffmann-La Roche||August 2016||Phase 2|
|NCT02670707||Recruiting||Drug: Cytarabine|Drug: Vinblastine/prednisone||Langerhans Cell Histiocytosis||Baylor College of Medicine||March 7 2016||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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