Vinblastine sulfate

For research use only.

Catalog No.S4505 Synonyms: NSC49842, Vincaleukoblastine sulfate salt

21 publications

Vinblastine sulfate Chemical Structure

CAS No. 143-67-9

Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.

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Selleck's Vinblastine sulfate has been cited by 21 publications

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Biological Activity

Description Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.
Targets
nAChR [1]
(Adrenal Chromaffin Cells)
8.9 μM
In vitro

The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding[3]. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block[4]. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COLO 320 human colorectal carcinoma cell line MmTISpVv[3Srb36gZZN{[Xl? NIO4VZlKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJItqdGxiNUClJI9nKEORTF:gN|IxKGi3bXHuJINwdG:{ZXP0ZYwh[2G{Y3nuc41iKGOnbHygcIlv\SxiRVO1NF0xNjB6IN88US=> NIfPU|gyOjN4MUO5Oy=>
LNCaP human prostate cancer cell line NFXkdHhHfW6ldHnvckBie3OjeR?= Mnr5TY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDrbYxtKDVyJTDv[kBNVkOjUDDoeY1idiCycn;zeIF1\SClYX7j[ZIh[2WubDDsbY5mNCCHQ{WwQVAvPSEQvF2= NYXlWXdKOTJ|NkGzPVc>
K562 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLlfZJmUW5idnn0do8hcW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3jyc45q[yCveXXsc4dmdm:3czDs[ZVs\W2rYTDLOVYzKGOnbHyg[5Jwf3SqLDDJR|UxRTBwMECxJO69VQ>? NVzOVIduOTJ6NUK3Olg>
T47D cells M4DJO2Z2dmO2aX;uJIF{e2G7 NWLUS4hUUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BscWyuIEWwKUBw\iCWNEfEJIh2dWGwIHLy[YF{fCCmdXP0ZYwh[2G{Y3nuc41iKGOnbHygcIlv\SxiRVO1NF0xNjB6IN88US=> M4nKSlEzOzZzM{m3
K562 cell NWr3eWJoWHKxbHnm[ZJifGmxbjDhd5NigQ>? MVe0PEBp MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBKSzVyPUCuNFAyKM7:TR?= M3zxO|E6OjJyMEG4
ACHN cells M3PCdmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIq1[W41QCCq MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBR2hPKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MkKuO{DPxE1? NYjncJZnOTl2Nke4O|c>
A375 cells NXTvbFFZS3m2b4TvfIlkcXS7IHHzd4F6 MYm0PEBp M2fSc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE{PzViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23MlIh|ryP MX6xPVQ3Pzh5Nx?=
C32 cells MUnDfZRwfG:6aXPpeJkh[XO|YYm= MXG0PEBp MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDN|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1|IN88US=> M1nN[|E6PDZ5OEe3
LNCAP cells NGDLUI1EgXSxdH;4bYNqfHliYYPzZZk> Mn\TOFghcA>? MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUK5MlMh|ryP NUe4T3l{OTl2Nke4O|c>
Huh-7D12 cells M3znZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MljQOFghcA>? M{XZeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cC15REGyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:PDVwNjFOwG0> Mnj4NVk1Pjd6N{e=
COR-L23 cells M{jEdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MoXWOFghcA>? M3jaVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNQWi2OMkOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF01PS53IN88US=> NXXZfHZnOTl2Nke4O|c>
142BR cells NWrHSZZUS3m2b4TvfIlkcXS7IHHzd4F6 NXPISpl3PDhiaB?= Mk\NR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVQzSlJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2zO{43KM7:TR?= M4HnfVE6PDZ5OEe3
HT-29 cells MYDDfZRwfG:6aXPpeJkh[XO|YYm= NYPhSld1PDhiaB?= MlvzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlU2KM7:TR?= M3XyUFIyQTJyN{[y
A549 cells M{mwTnBzd2yrZnXyZZRqd25iYYPzZZk> MnPJOFghcA>? MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0zNjN4IN88US=> M{fQRlIzPTR4Nke0
DU145 cells NHPrdFlRem:uaX\ldoF1cW:wIHHzd4F6 NXi0V3pwPDhiaB?= NIDTfZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;ND6yOUDPxE1? NI\pe2czOjV2Nk[3OC=>
SK-MEL-5 cells MlHLVJJwdGmoZYLheIlwdiCjc4PhfS=> NX\BW3ZDPDhiaB?= NHrzc4dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW1GVC13IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NU44PCEQvF2= MWeyNlU1PjZ5NB?=
HepG2 cells NEL2V3pRem:uaX\ldoF1cW:wIHHzd4F6 MlfEOFghcA>? NX7hSHRGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNVYh|ryP M1\1SFIzPTR4Nke0
HT-29 cells M{CzWnBzd2yrZnXyZZRqd25iYYPzZZk> NWPBcWN7PDhiaB?= NYHmZWpySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGxMlE5KM7:TR?= NGHWVm4zOjV2Nk[3OC=>
MCF7 cells MWTQdo9tcW[ncnH0bY9vKGG|c3H5 NWrOO3dRPDhiaB?= MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0zPC5yODFOwG0> NInMTpgzOjV2Nk[3OC=>
MDA-MB-231 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 NWnnOIVPPDhiaB?= NF7jXodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0{OS53MjFOwG0> NEPvNnAzOjV2Nk[3OC=>
rat REF52 cells NWO4eldQTnWwY4Tpc44h[XO|YYm= NUPMcmN4OC5zIN88US=> MXezNEBucW6| NWj2[JVoUW6mdXP0bY9vKG:oIH3pZ5JwfHWkdXzlJIRmeG:ueX3ldol7[XSrb36gbY4hemG2IGLFSlUzKGOnbHzzJIF1KDBwMTD1UUBi\nSncjCzNEBucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfS=> MXGyN|k1Pzh{Nh?=
HepG2 cells MofZR5l1d3SxeHnjbZR6KGG|c3H5 NEi4SGU4OiCq M1rRcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGGmcnnhcZlkcW5vcnXzbZN1[W62IHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wOVYh|ryP MVyyN|cxQDBzMB?=
HepG2 cells NIjXOHlEgXSxdH;4bYNqfHliYYPzZZk> M1rlVFczKGh? MlmyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjBzOTFOwG0> M1[5UFI{PzB6MEGw
K562 cells NYD4c|RnS3m2b4TvfIlkcXS7IHHzd4F6 Ml[2O|IhcA>? MnzqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF4IN88US=> NVz0PZdIOjN5MEiwNVA>
MDA-MB-231 cells NVzSNVZXS3m2b4TvfIlkcXS7IHHzd4F6 M4HR[lczKGh? M{T1RmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlAxQDNizszN MnGzNlM4ODhyMUC=
MCF7 cells M4XuO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MojJO|IhcA>? Mm\HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB5IN88US=> NHrCenozOzdyOECxNC=>
SCL6 cells MWLDfZRwfG:6aXPpeJkh[XO|YYm= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTR2w3KGOnbHzzJIJ6KE2WVDDhd5NigSxiRVS1NF03NjFizqzt NVG2cVM4OTJ6OECzNVQ>
SCL9 NGi2cXhEgXSxdH;4bYNqfHliYYPzZZk> NVm1S3hVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0OOOTDj[YxteyCkeTDNWHQh[XO|YYmsJGVFRTVwMzFOwG0> NVXPNo1OOTJ6OECzNVQ>
KATO III cells MWLDfZRwfG:6aXPpeJkh[XO|YYm= NHe4NYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSVSRIFnJTUBk\WyuczDifUBOXFRiYYPzZZktKEWGNUC9Ok4yKM7:TR?= NHXNT5cyOjh6MEOxOC=>
NUGC4 cells NH71TohEgXSxdH;4bYNqfHliYYPzZZk> M3r5WWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5WT0N2IHPlcIx{KGK7IF3UWEBie3OjeTygSWQ2OD13LkOg{txO NGWwSnYyOjh6MEOxOC=>
UACC903 cells NF3pcGVEgXSxdH;4bYNqfHliYYPzZZk> NUDXd4dRPDhiaB?= NYCyWWhoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQ{mwN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTFwNkWg{txO NUHGe4x1OjF7MkC3OlI>
K562 cells NIjKUIRHfW6ldHnvckBie3OjeR?= NF7UdplKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44hcW5iaIXtZY4hUzV4MjDj[YxteyxiSVO1NF0xNjF|IN88US=> MVWyNFU1Pjl6MB?=
BxPC3 cells NGPC[mVRem:uaX\ldoF1cW:wIHHzd4F6 NHXqOXc1QCCq MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OS5zMzFOwG0> MViyNlU1PjZ5NB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
GRP78 ; 

PubMed: 19674193     


Taxol and vinblastine induce GRP78 expression in breast cancer cells. (A) ZR75-30 cells were treated with taxol and vinblastine for 24 hrs. Cell lysates were harvested and subjected to Western blot analysis with anti-GRP78 antibody. -actin was probed as a loading control. (B) Western blot analysis of GRP78 expression in response to taxol and vinblastine treatments in T47D cells. (C) Western blot analysis of GRP78 expression in response to taxol and vinblastine treatments in MCF-7 cells. (D) MCF-7 cells were treated with 0.5 μM taxol and 0.1 μM vinblastine for indicated hours. Cell lysates were harvested and subjected to Western blot analysis with anti-GRP78 antibody.

p-eIF2; 

PubMed: 19674193     


MCF-7 cells were treated with 0.5 μM taxol and 0.1 μM vinblastine for indicated periods. Total proteins were harvested and subjected to Western blot analysis of the phosphorylated eIF2α.

p-JNK / c-Caspase-7 / c-PARP ; 

PubMed: 19674193     


MCF-7 cells were treated with indicated doses of taxol and vinblastine for 24 hrs. Total proteins were harvested and subjected to Western blot analysis of the phosphorylated JNK, cleaved caspase-7 and PARP.

ERK / p-ERK / Mcl-1 / Bad / Bid / Noxa ; 

PubMed: 20371726     


Expression of Bcl-2 family members and activation of MAPK proteins in the panel of cell lines. The indicated cell lines were either undamaged or incubated with 2.2 μM vinblastine for 4 h. Lysates were analyzed by immunoblotting for expression of the indicated proteins.

19674193 20371726
Immunofluorescence
α-tubulin / Acetyl tubulin ; 

PubMed: 30120268     


Differentiated SH-SY5Y cells were incubated in the absence and presence of indibulin (25 nM), vinblastine (10 nM) and colchicine (10 nM) for 24 h. Cells were fixed and processed for immunostaining with antibodies against α-tubulin (green) and acetylated tubulin (red). Cells were observed at two magnifications under a microscope. Scale bar = 100 and 10 μm in low (Left panel) and high (Right panel) magnification, respectively.

30120268
Growth inhibition assay
Cell viability; 

PubMed: 27114800     


Panel (A) shows cell viability (%) of the cells after 24 and 48 hrs incubation with vinblastine (0-100 nM) or docetaxel (0-100 nM). 

27114800
In vivo Vinblastine is a widely used anticancer drug with undesired side effects [6]. A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo[4]. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin)[5].

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: Chinese hamster ovary (CHO) cells
  • Concentrations: 1% (v/v) (dissolved in DMSO)
  • Incubation Time: 3h
  • Method:

    Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (110.0 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 909.05
Formula

C46H58N4O9.H2SO4

CAS No. 143-67-9
Storage powder
in solvent
Synonyms NSC49842, Vincaleukoblastine sulfate salt
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02840409 Recruiting Drug: Vinblastine|Drug: Bevacizumab Low Grade Glioma The Hospital for Sick Children|Hoffmann-La Roche August 2016 Phase 2
NCT02670707 Recruiting Drug: Cytarabine|Drug: Vinblastine/prednisone Langerhans Cell Histiocytosis Baylor College of Medicine March 7 2016 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID