Vinblastine sulfate

Catalog No.S4505 Synonyms: NSC49842

Vinblastine sulfate Chemical Structure

Molecular Weight(MW): 909.05

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

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Biological Activity

Description Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
Targets
nAChR [1]
(Adrenal Chromaffin Cells)
8.9 μM
In vitro

The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding[3]. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block[4]. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COLO 320 human colorectal carcinoma cell line NHrpZmRHfW6ldHnvckBie3OjeR?= M1vGU2lvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gb4ltdCB3MDWgc4YhS0:OTzCzNlAhcHWvYX6gZ49td3KnY4ThcEBk[XKlaX7vcYEh[2WubDDsbY5mNCCHQ{WwQVAvODhizszN MknVNVI{PjF|OUe=
LNCaP human prostate cancer cell line MWPGeY5kfGmxbjDhd5NigQ>? NXflO3dwUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BscWyuIEWwKUBw\iCOTlPhVEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscEBtcW6nLDDFR|UxRTBwNTFOwG0> NWi5cGlyOTJ|NkGzPVc>
K562 cell NHfyfYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjNTY4hfmm2cn:gbY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaIXtZY4h[2i{b37pZ{BugWWub3flco92eyCuZYXr[Y1q[SCNNU[yJINmdGxiZ4Lve5RpNCCLQ{WwQVAvODBzIN88US=> NXnXN5VPOTJ6NUK3Olg>
T47D cells M{D1fGZ2dmO2aX;uJIF{e2G7 MVXJckB3cXS{bzDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHvpcIwhPTBnIH;mJHQ1P0RiaIXtZY4h[nKnYYP0JIR2[3SjbDDjZZJkcW6xbXGgZ4VtdCCuaX7lMEBGSzVyPUCuNFgh|ryP M4[2O|EzOzZzM{m3
K562 cell Ml;NVJJwdGmoZYLheIlwdiCjc4PhfS=> NF\Dd2c1QCCq M3XQS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMtKEmFNUC9NE4xODFizszN MU[xPVIzODBzOB?=
ACHN cells MoPFR5l1d3SxeHnjbZR6KGG|c3H5 MmXDOFghcA>? MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBR2hPKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MkKuO{DPxE1? MlLINVk1Pjd6N{e=
A375 cells MWrDfZRwfG:6aXPpeJkh[XO|YYm= M2Pp[VQ5KGh? NYXTOI5iS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTN5NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvOiEQvF2= M1XZNFE6PDZ5OEe3
C32 cells MYnDfZRwfG:6aXPpeJkh[XO|YYm= M33lZlQ5KGh? NH7oR4VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEOzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2zJO69VQ>? MmnxNVk1Pjd6N{e=
LNCAP cells Mk\2R5l1d3SxeHnjbZR6KGG|c3H5 Mo[4OFghcA>? MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUK5MlMh|ryP NWPTdoxOOTl2Nke4O|c>
Huh-7D12 cells MkTCR5l1d3SxeHnjbZR6KGG|c3H5 NE\5b2w1QCCq NHz2b3BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWhvN1SxNkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTR3Lk[g{txO M{P0eVE6PDZ5OEe3
COR-L23 cells NVSyemFnS3m2b4TvfIlkcXS7IHHzd4F6 M322RlQ5KGh? MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU3IuVDJ|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OFUvPSEQvF2= M17wdVE6PDZ5OEe3
142BR cells NU[ye2xsS3m2b4TvfIlkcXS7IHHzd4F6 MX20PEBp NXPpTJRMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOTR{QmKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0{Py54IN88US=> NFTZO5AyQTR4N{i3Oy=>
HT-29 cells NILD[3BEgXSxdH;4bYNqfHliYYPzZZk> NUnkTnZRPDhiaB?= MluyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlU2KM7:TR?= NVTDWoRmOjF7MkC3OlI>
A549 cells NInFTIFRem:uaX\ldoF1cW:wIHHzd4F6 MVW0PEBp MlPqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:Oi5|NjFOwG0> MU[yNlU1PjZ5NB?=
DU145 cells NH3sZo5Rem:uaX\ldoF1cW:wIHHzd4F6 MW[0PEBp MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:PC5{NTFOwG0> MljlNlI2PDZ4N{S=
SK-MEL-5 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 NXHSO2RTPDhiaB?= NGjIS2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW1GVC13IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NU44PCEQvF2= MVyyNlU1PjZ5NB?=
HepG2 cells MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 NEC3TXQ1QCCq MlrjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTBwMU[g{txO NEjjdIEzOjV2Nk[3OC=>
HT-29 cells MmLBVJJwdGmoZYLheIlwdiCjc4PhfS=> NIW1ZlY1QCCq M2LaZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1zMT6xPEDPxE1? M2jvN|IzPTR4Nke0
MCF7 cells NEDFeINRem:uaX\ldoF1cW:wIHHzd4F6 MWS0PEBp MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0zPC5yODFOwG0> MUSyNlU1PjZ5NB?=
MDA-MB-231 cells NXnu[4dMWHKxbHnm[ZJifGmxbjDhd5NigQ>? MW[0PEBp NVK5SIx3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OzFwNUKg{txO NGDBWoQzOjV2Nk[3OC=>
rat REF52 cells NXjUWIdzTnWwY4Tpc44h[XO|YYm= MVqwMlEh|ryP MX:zNEBucW6| MVHJcoR2[3Srb36gc4YhdWmlcn;0eYJ2dGViZHXwc4x6dWW{aYrheIlwdiCrbjDyZZQhWkWINUKgZ4VtdHNiYYSgNE4yKHWPIHHmeIVzKDNyIH3pcpMh[nliZnz1c5Jme2OnbnPlJIF{e2G7 NFTaOXUzOzl2N{iyOi=>
HepG2 cells M{jSNWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlfLO|IhcA>? NEjCTXFEgXSxdH;4bYNqfHliYXfhbY5{fCCjZILpZY16[2mwLYLld4l{fGGwdDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFU3KM7:TR?= MnHENlM4ODhyMUC=
HepG2 cells NHj1WVVEgXSxdH;4bYNqfHliYYPzZZk> M1THb|czKGh? MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF7IN88US=> NVzpT4dmOjN5MEiwNVA>
K562 cells M3fOXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1XGfFczKGh? MnjxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF4IN88US=> MX2yN|cxQDBzMB?=
MDA-MB-231 cells Ml;GR5l1d3SxeHnjbZR6KGG|c3H5 NUPyT|QxPzJiaB?= MnziR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFA5OyEQvF2= M122eVI{PzB6MEGw
MCF7 cells NH34U4ZEgXSxdH;4bYNqfHliYYPzZZk> MljsO|IhcA>? M4\HeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjByNzFOwG0> NWDtPYdIOjN5MEiwNVA>
SCL6 cells M2q1OGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmHlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2NNPiClZXzsd{BjgSCPVGSgZZN{[XluIFXEOVA:Pi5zIN8ccS=> NFO2cYMyOjh6MEOxOC=>
SCL9 M{HBO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MkTxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2NNQSClZXzsd{BjgSCPVGSgZZN{[XluIFXEQVUvOyEQvF2= NEnWd4gyOjh6MEOxOC=>
KATO III cells NHSzNI5EgXSxdH;4bYNqfHliYYPzZZk> M3u5PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtCXE9iSVnJJINmdGy|IHL5JG1VXCCjc4PhfUwhTUR3ME22MlEh|ryP NWHldYtYOTJ6OECzNVQ>
NUGC4 cells NIDzSHJEgXSxdH;4bYNqfHliYYPzZZk> M{DWUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5WT0N2IHPlcIx{KGK7IF3UWEBie3OjeTygSWQ2OD13LkOg{txO MVOxNlg5ODNzNB?=
UACC903 cells M{Oyd2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2PWU|Q5KGh? NWLjVYFZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQ{mwN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTFwNkWg{txO NUfuUphqOjF7MkC3OlI>
K562 cells MnfnSpVv[3Srb36gZZN{[Xl? NIPIRVhKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44hcW5iaIXtZY4hUzV4MjDj[YxteyxiSVO1NF0xNjF|IN88US=> MoHqNlA2PDZ7OEC=
BxPC3 cells M{DwfHBzd2yrZnXyZZRqd25iYYPzZZk> MnvUOFghcA>? NFLCW5RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFL4VGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MT6xN{DPxE1? NYLRNpJqOjJ3NE[2O|Q>

... Click to View More Cell Line Experimental Data

In vivo Vinblastine is a widely used anticancer drug with undesired side effects [6]. A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo[4]. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin)[5].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: Chinese hamster ovary (CHO) cells
  • Concentrations: 1% (v/v) (dissolved in DMSO)
  • Incubation Time: 3h
  • Method:

    Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (110.0 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 909.05
Formula

C46H58N4O9.H2SO4

CAS No. 143-67-9
Storage powder
in solvent
Synonyms NSC49842

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02840409 Recruiting Drug: Vinblastine|Drug: Bevacizumab Low Grade Glioma The Hospital for Sick Children|Hoffmann-La Roche August 2016 Phase 2
NCT02670707 Recruiting Drug: Cytarabine|Drug: Vinblastine/prednisone Langerhans Cell Histiocytosis Baylor College of Medicine|Texas Children''s Hospital March 7 2016 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID