Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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Cited by 20 Publications

9 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPodXJKSzVyPUCuNFAxOzB|IN88US=> NEDJWWZUSU6JRWK=
IST-MEL1 NUXZTnJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\FTGpKSzVyPUCuNFAxPDB5IN88US=> NUDsTpNqW0GQR1XS
NCI-SNU-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMECyNFch|ryP NIGweVhUSU6JRWK=
FADU MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfLTWM2OD1yLkCwNlA6KM7:TR?= M1P4ZnNCVkeHUh?=
C32 M4HYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXRTWM2OD1yLkCwN|A1KM7:TR?= M4XrfnNCVkeHUh?=
D-566MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMECzPUDPxE1? NYn6XJVHW0GQR1XS
LXF-289 M4LL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\4d2lEPTB;MD6wNFQyQSEQvF2= NGf5ZpVUSU6JRWK=
HGC-27 M4DQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TqSmlEPTB;MD6wNFUyKM7:TR?= MWPTRW5ITVJ?
RPMI-7951 M1TLUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqycnNkUUN3ME2wMlAxPzF5IN88US=> NVTwPVhwW0GQR1XS
HSC-3 NVz4fWVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jxeWlEPTB;MD6wNFkzQSEQvF2= M1PkcXNCVkeHUh?=
MIA-PaCa-2 NEPQWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHqTWM2OD1yLkCxNFA6KM7:TR?= M1ztcXNCVkeHUh?=
KS-1 NHXkfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEGzOVUh|ryP M3jFbHNCVkeHUh?=
CAL-51 M4Pob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEG0NFUh|ryP MmrrV2FPT0WU
MDA-MB-361 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;mR4xKSzVyPUCuNFE1QTVizszN MoDFV2FPT0WU
TI-73 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrpTWM2OD1yLkCxO|k3KM7:TR?= Mnu3V2FPT0WU
AGS NEDPRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf1Row1UUN3ME2wMlAyQTN6IN88US=> MYDTRW5ITVJ?
NCI-H460 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEG5O|Qh|ryP NW\QS5FoW0GQR1XS
A204 MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DyXWlEPTB;MD6wNlI1QSEQvF2= M1mz[XNCVkeHUh?=
CHL-1 NWPaV5hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEKyOVEh|ryP MoTXV2FPT0WU
DU-4475 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjxWWRKSzVyPUCuNFIzPjFizszN NGTZUVBUSU6JRWK=
CGTH-W-1 NEnWXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorsTWM2OD1yLkCyN|Q6KM7:TR?= NX;idpY6W0GQR1XS
HCC2218 M2e0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PRdmlEPTB;MD6wNlQ6PCEQvF2= NVjtc3NjW0GQR1XS
A2780 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfj[YNKSzVyPUCuNFI2OzFizszN NX;XR3oxW0GQR1XS
NCI-H720 NUHpdmdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGSzZnNKSzVyPUCuNFI2PDZizszN MWDTRW5ITVJ?
NCI-N87 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P1SGlEPTB;MD6wNlU6OyEQvF2= NXPDXFhsW0GQR1XS
CHP-212 M4CzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLpTWM2OD1yLkCyOlI5KM7:TR?= MmjvV2FPT0WU
NCI-H23 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfKTWM2OD1yLkCyOlY2KM7:TR?= NWCxco1KW0GQR1XS
D-263MG MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEK3PFYh|ryP MofoV2FPT0WU
ME-180 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj5fFdKSzVyPUCuNFI5QTFizszN MV\TRW5ITVJ?
SW982 NEDlbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvHSFRKSzVyPUCuNFI6QTlizszN NVXWSZU{W0GQR1XS
OE19 NEHBSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq2SYVVUUN3ME2wMlA{ODd5IN88US=> MWfTRW5ITVJ?
SK-LU-1 M4n1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXlTWM2OD1yLkCzNFgzKM7:TR?= M1HYb3NCVkeHUh?=
H4 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[xZYVKSzVyPUCuNFMxQSEQvF2= MWLTRW5ITVJ?
HT-144 MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLsTWM2OD1yLkCzNFk{KM7:TR?= M1\vcXNCVkeHUh?=
SK-UT-1 NFPrRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjob4VKSzVyPUCuNFMyPzhizszN MkOwV2FPT0WU
D-336MG MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWydFlKSzVyPUCuNFM{ODlizszN NU\uSW5sW0GQR1XS
MDA-MB-175-VII MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\wU2tKSzVyPUCuNFM{PTRizszN MnrCV2FPT0WU
GAMG NG\mW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILDRmVKSzVyPUCuNFM1OzVizszN NYjxWHUxW0GQR1XS
CP50-MEL-B MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\QSmVKSzVyPUCuNFM1PSEQvF2= MYDTRW5ITVJ?
OVCAR-5 M{Hndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEO0PEDPxE1? M3rqWXNCVkeHUh?=
SK-MES-1 NH3O[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEO2NFYh|ryP NEexfplUSU6JRWK=
VM-CUB-1 M4LtOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV34cXU1UUN3ME2wMlA{PjV5IN88US=> MVnTRW5ITVJ?
WM-115 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzZdm9FUUN3ME2wMlA{PzZ{IN88US=> MWnTRW5ITVJ?
DSH1 NXi5c3AyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonUTWM2OD1yLkCzPFA4KM7:TR?= NV20dG9tW0GQR1XS
Becker M{jyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[5TWM2OD1yLkCzPFg2KM7:TR?= M2LQfHNCVkeHUh?=
SW962 NHzIWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLaTWM2OD1yLkCzPVQ2KM7:TR?= NYm2WlZZW0GQR1XS
TYK-nu M{\ROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnl[ZdPUUN3ME2wMlA{QTh3IN88US=> NIrRWJNUSU6JRWK=
HO-1-N-1 NI\nXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMESwNlEh|ryP NFPDdWZUSU6JRWK=
T98G M1PTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMESxNFMh|ryP MnK2V2FPT0WU
ACN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jyUWlEPTB;MD6wOFE3OiEQvF2= NXvoPFBFW0GQR1XS
SW780 NImyfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHTTWM2OD1yLkC0NlA{KM7:TR?= M3;GPXNCVkeHUh?=
Detroit562 NEftNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TVVmlEPTB;MD6wOFI{QSEQvF2= MXfTRW5ITVJ?
BB49-HNC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljKTWM2OD1yLkC0NlQ{KM7:TR?= MVjTRW5ITVJ?
HN NF23XWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIriXlBKSzVyPUCuNFQzPzJizszN NXzUVpY5W0GQR1XS
H9 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPUN3JKSzVyPUCuNFQ{PzFizszN MUnTRW5ITVJ?
VA-ES-BJ NHrCWIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTTb5oyUUN3ME2wMlA1PDR5IN88US=> NFvuW2RUSU6JRWK=
MEL-JUSO NGHJXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LvUGlEPTB;MD6wOFQ4PSEQvF2= M3fX[HNCVkeHUh?=
BT-474 NH;STHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHkTWM2OD1yLkC0OUDPxE1? MmTCV2FPT0WU
CaR-1 NVr4PGpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW4TWM2OD1yLkC0OVQ6KM7:TR?= MnO3V2FPT0WU
PSN1 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMES2NFMh|ryP NHzGVo5USU6JRWK=
KYSE-510 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMES2OFkh|ryP NVfHUo9VW0GQR1XS
KP-4 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMES3OVMh|ryP MXXTRW5ITVJ?
KYSE-410 NILGNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMES3O|Ih|ryP NHnRUXdUSU6JRWK=
G-402 NEnFbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fXTWlEPTB;MD6wOFc5QSEQvF2= NX6zblVZW0GQR1XS
DOK NUW2b2JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jacGlEPTB;MD6wOFkxOiEQvF2= MUTTRW5ITVJ?
COR-L88 NEj3fIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy2WGNlUUN3ME2wMlA1QTF{IN88US=> MkexV2FPT0WU
SKG-IIIa MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXtTWM2OD1yLkC0PVg3KM7:TR?= MmK5V2FPT0WU
AN3-CA MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LRd2lEPTB;MD6wOUDPxE1? NHX6Z|ZUSU6JRWK=
SW48 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLIPJI1UUN3ME2wMlA2ODN7IN88US=> MUnTRW5ITVJ?
YKG-1 NG\oNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nK[GlEPTB;MD6wOVA4OSEQvF2= MX;TRW5ITVJ?
KYSE-150 M3PyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT2TWM2OD1yLkC1NlM2KM7:TR?= NHryZ5lUSU6JRWK=
HuO-3N1 M1\Bemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe3bWltUUN3ME2wMlA2OjN5IN88US=> NHvxVJhUSU6JRWK=
LB1047-RCC NITFTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nicmlEPTB;MD6wOVI6PiEQvF2= NUW5XoJJW0GQR1XS
NCI-H2030 NETWcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEW0NVQh|ryP MkLyV2FPT0WU
YH-13 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjRfIpbUUN3ME2wMlA2PzJ{IN88US=> NGn3NHNUSU6JRWK=
5637 NIrKfI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq1XoFKSzVyPUCuNFU4PCEQvF2= MWjTRW5ITVJ?
LOXIMVI M1y1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXlOZhKSzVyPUCuNFU5PzJizszN M2n6Z3NCVkeHUh?=
GT3TKB NH7jeVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPPepNOUUN3ME2wMlA2QTR{IN88US=> NHToSFBUSU6JRWK=
TCCSUP MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDkPVh{UUN3ME2wMlA2QTZ2IN88US=> NWj2[WI3W0GQR1XS
EPLC-272H NX[xS5ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fqSWlEPTB;MD6wOlIxPSEQvF2= NF\lSmtUSU6JRWK=
LU-99A MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwME[yN|ch|ryP MnXMV2FPT0WU
NCI-H1755 MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7VTm92UUN3ME2wMlA3OzRzIN88US=> M1PwfHNCVkeHUh?=
KM12 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfUTWM2OD1yLkC2N|Q5KM7:TR?= MkT4V2FPT0WU
SF295 NFHW[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwME[0OVIh|ryP NUfvOWZbW0GQR1XS
MZ2-MEL Mn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DWfWlEPTB;MD6wOlU2OyEQvF2= MYXTRW5ITVJ?
HEC-1 M{DwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LUN2lEPTB;MD6wOlU5QCEQvF2= NWLCV4MxW0GQR1XS
SW684 M3i1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwME[1PVEh|ryP M1XtNXNCVkeHUh?=
SF539 NWm4WYxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwME[2PFEh|ryP NFK3WXJUSU6JRWK=
GMS-10 M4X4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH6ZnMyUUN3ME2wMlA3Pjl7IN88US=> MnjmV2FPT0WU
MV-4-11 NU\KTHcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vmOGlEPTB;MD6wOlgxOyEQvF2= MkHlV2FPT0WU
HT-29 NXTFOnlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S4bGlEPTB;MD6wOlkyQSEQvF2= M3HkenNCVkeHUh?=
23132-87 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInLZ|FKSzVyPUCuNFY6PSEQvF2= MVvTRW5ITVJ?
SW620 M33QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS0N2FKSzVyPUCuNFcxOjZizszN NXfTNHdXW0GQR1XS
HCC1806 NUXDPWFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK2VmI{UUN3ME2wMlA4OTNzIN88US=> MWTTRW5ITVJ?
Hs-578-T MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHO[ZhMUUN3ME2wMlA4OjB6IN88US=> M4TTVXNCVkeHUh?=
A2058 NWW1codET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEeyNlgh|ryP MXvTRW5ITVJ?
MEL-HO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjvb5JGUUN3ME2wMlA4OjV3IN88US=> NYSyO4ZPW0GQR1XS
HCC2998 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\5UFRKSzVyPUCuNFc{PDdizszN Ml;4V2FPT0WU
HuO9 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEe1PFkh|ryP M4\odXNCVkeHUh?=
CAL-39 NF24TYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ewNWlEPTB;MD6wO|c3PiEQvF2= M4jENnNCVkeHUh?=
M14 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEe5NVMh|ryP NWLwUVZOW0GQR1XS
BFTC-909 NV30OVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHi[ZB5UUN3ME2wMlA4QTZ7IN88US=> M3P3WHNCVkeHUh?=
TE-11 M3rLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HFOGlEPTB;MD6wO|k6PiEQvF2= MWrTRW5ITVJ?
TGBC1TKB NX;1eGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f3eGlEPTB;MD6wPFA1OyEQvF2= M2[3XHNCVkeHUh?=
L-363 NGfvZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEiyNFYh|ryP M37JZXNCVkeHUh?=
A431 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEiyNUDPxE1? NXXOXHhyW0GQR1XS
MKN45 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzHTWM2OD1yLkC4NlE6KM7:TR?= NUHSXpZYW0GQR1XS
HT-1080 M4q4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn6TWM2OD1yLkC4OFM6KM7:TR?= MkHuV2FPT0WU
OVCAR-8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEi2NlIh|ryP MUHTRW5ITVJ?
LCLC-97TM1 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zRXmlEPTB;MD6wPFczQCEQvF2= NWryTXQ5W0GQR1XS
M059J NFTHeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm1TWM2OD1yLkC5NFI4KM7:TR?= MVzTRW5ITVJ?
SK-MEL-2 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ZSGpKSzVyPUCuNFkxPiEQvF2= MXnTRW5ITVJ?
TE-1 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnGXJVKSzVyPUCuNFkzODRizszN MkXWV2FPT0WU
KYSE-180 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7FXFV1UUN3ME2wMlA6OjZ{IN88US=> M1jqdHNCVkeHUh?=
D-247MG MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKwbIRKSzVyPUCuNFk1PTVizszN NEHKd4pUSU6JRWK=
8-MG-BA MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7STlFKSzVyPUCuNFk1PzJizszN MnjCV2FPT0WU
NCI-H1792 NGew[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfPVlFHUUN3ME2wMlA6PjF6IN88US=> MoDOV2FPT0WU
MCF7 NFLwPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfvRVdVUUN3ME2wMlA6Pjd5IN88US=> NYO0[5lZW0GQR1XS
NCI-H2122 NVTrNIF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrlTWM2OD1yLkC5O|Q2KM7:TR?= NU\BdmVuW0GQR1XS
EFO-27 M332b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEm5PVch|ryP MXXTRW5ITVJ?
LB2241-RCC NX70Oo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jSRWlEPTB;MD6xNFA2PCEQvF2= NILTcVhUSU6JRWK=
SN12C MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7yZ2E4UUN3ME2wMlExOTB5IN88US=> NVXBZWhVW0GQR1XS
A498 M3\ZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMUCxPEDPxE1? NXHpc2dHW0GQR1XS
PANC-03-27 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm2Z3RKSzVyPUCuNVAzQDZizszN MV;TRW5ITVJ?
NCI-H1581 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zhfGlEPTB;MD6xNFI6KM7:TR?= NGHDVXhUSU6JRWK=
U-87-MG NHP5PW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorUTWM2OD1yLkGwN|A4KM7:TR?= NYP3OnpZW0GQR1XS
G-401 NYrUbFJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMUCzOVMh|ryP NF\tfmFUSU6JRWK=
SiHa MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HUXmlEPTB;MD6xNFQ5PiEQvF2= M2HzfnNCVkeHUh?=
U251 NGXaTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TLd2lEPTB;MD6xNFUzPSEQvF2= M2rTe3NCVkeHUh?=
MMAC-SF MljrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD5UHdKSzVyPUCuNVA2OzFizszN Mn3LV2FPT0WU
BB65-RCC NVmxZmxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fnW2lEPTB;MD6xNFU2PCEQvF2= NUH0[IxSW0GQR1XS
NKM-1 NYDKPHBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DF[2lEPTB;MD6xNFY3PiEQvF2= MX3TRW5ITVJ?
HD-MY-Z M3PQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuwTWM2OD1yLkGwPFc{KM7:TR?= NVHVfZJYW0GQR1XS
TGBC11TKB MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj5ZVVKSzVyPUCuNVA6ODNizszN MWfTRW5ITVJ?
COLO-679 NXXxW5BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELy[3lKSzVyPUCuNVEzOTFizszN M4L2UXNCVkeHUh?=
TE-8 NFT4[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXKTWM2OD1yLkGxNlY1KM7:TR?= NVz3dpQxW0GQR1XS
SK-MEL-28 NXnJNHRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvFW3Z[UUN3ME2wMlEyOzJzIN88US=> M2XDN3NCVkeHUh?=
SH-4 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULQW4hRUUN3ME2wMlEyOzV4IN88US=> NFTaRY9USU6JRWK=
KALS-1 NF\lU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\HTWM2OD1yLkGxN|k{KM7:TR?= NH\6U|lUSU6JRWK=
RKO M4\sSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\oXW1KSzVyPUCuNVE4PjRizszN M3O0RnNCVkeHUh?=
OMC-1 NX7qdWxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;OPWdKSzVyPUCuNVE4QTdizszN NGDoeYVUSU6JRWK=
BT-549 M4jvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:0TWM2OD1yLkGxO|k6KM7:TR?= NH:1fWNUSU6JRWK=
NCI-H28 NXfMTnF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUG4NVch|ryP MoTaV2FPT0WU
RXF393 M{\id2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m0NmlEPTB;MD6xNVk5OiEQvF2= NFm3SYtUSU6JRWK=
COLO-829 NWTCUVZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETmZpFKSzVyPUCuNVIxODVizszN M3:2VnNCVkeHUh?=
HMV-II NUTJUW1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[1WWtKSzVyPUCuNVIxOiEQvF2= MmLlV2FPT0WU
SW1990 M3;ReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvjUoxKSzVyPUCuNVIyPTdizszN MXXTRW5ITVJ?
NCI-H1437 MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PtT2lEPTB;MD6xNlE2PyEQvF2= MX\TRW5ITVJ?
SNB75 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S3e2lEPTB;MD6xNlE3QSEQvF2= M2nIUnNCVkeHUh?=
EW-3 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInYW3BKSzVyPUCuNVI3PjFizszN NUnUSoo2W0GQR1XS
SAS M3n5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T5eWlEPTB;MD6xNlY6KM7:TR?= MVPTRW5ITVJ?
NCI-H1666 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUK3O|Qh|ryP MYLTRW5ITVJ?
A375 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG3V3JKSzVyPUCuNVI4PzhizszN MV7TRW5ITVJ?
CAMA-1 NHywT3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zGdGlEPTB;MD6xNlkzPCEQvF2= M{XrZnNCVkeHUh?=
HuP-T4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\xVWlEPTB;MD6xNlk1OyEQvF2= M1nTW3NCVkeHUh?=
NCI-H292 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zSWmlEPTB;MD6xN|EyKM7:TR?= M{DBOnNCVkeHUh?=
PC-14 NHn5NYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DI[mlEPTB;MD6xN|IyOSEQvF2= M3:2RXNCVkeHUh?=
BPH-1 NYLMS2xzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nFUWlEPTB;MD6xN|QyKM7:TR?= MmDLV2FPT0WU
GAK NXXFNGNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nqW2lEPTB;MD6xN|U3PyEQvF2= M4e0bnNCVkeHUh?=
VMRC-RCZ NWLacFJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PUfmlEPTB;MD6xN|c3OiEQvF2= NHrsSXZUSU6JRWK=
SK-MEL-24 M4DXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUO4O{DPxE1? MY\TRW5ITVJ?
LB831-BLC M1;sNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMUO4PFMh|ryP MorKV2FPT0WU
NCI-H2452 M4Lhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TYWmlEPTB;MD6xN|k2PiEQvF2= MYjTRW5ITVJ?
RT-112 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUSwN|Uh|ryP NYDFdYJCW0GQR1XS
GP5d NXTES3FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\uO5BKSzVyPUCuNVQyODRizszN MYXTRW5ITVJ?
LC-2-ad MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfZVGREUUN3ME2wMlE1OTJzIN88US=> MoXrV2FPT0WU
MPP-89 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTieY1KSzVyPUCuNVQyOjVizszN NIr0PHBUSU6JRWK=
NUGC-3 M{i3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMUS0O|gh|ryP NFnE[FJUSU6JRWK=
GI-1 NIXjXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfRZ2lKSzVyPUCuNVQ2PThizszN M1nJPXNCVkeHUh?=
HCC1419 NYfNblRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT5TWM2OD1yLkG0OVc3KM7:TR?= MYDTRW5ITVJ?
SW1573 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rI[mlEPTB;MD6xOFc2QCEQvF2= MkTDV2FPT0WU
NCI-H2347 NEXwdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzheI5KSzVyPUCuNVQ5OzlizszN MVPTRW5ITVJ?
Mewo M1;TR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfTTWM2OD1yLkG0PFg6KM7:TR?= Mn;KV2FPT0WU
639-V NE\LcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nubGlEPTB;MD6xOVAyOyEQvF2= NXnyTpNHW0GQR1XS
AsPC-1 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMUWyNlUh|ryP NULxXHRHW0GQR1XS
NCI-H1648 NH:2WphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDzTGZKSzVyPUCuNVUzOzJizszN M1nqXHNCVkeHUh?=
786-0 NHfHTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;yTWM2OD1yLkG1N|gyKM7:TR?= MoP2V2FPT0WU
ETK-1 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zrZ2lEPTB;MD6xOVkh|ryP MkD1V2FPT0WU
BxPC-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHpZYlKSzVyPUCuNVU6PjZizszN NY\zcpJEW0GQR1XS
CAL-62 M{TzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\KTWM2OD1yLkG2NVY6KM7:TR?= NFXieYFUSU6JRWK=
HCC1937 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMU[yO|Uh|ryP M2jpZnNCVkeHUh?=
NCI-H1299 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrTbm1{UUN3ME2wMlE3Ojh3IN88US=> Mm\PV2FPT0WU
SW1088 NVfISYVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMU[0NVMh|ryP NFzq[ZVUSU6JRWK=
FTC-133 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMU[1OEDPxE1? M3\VcHNCVkeHUh?=
OC-314 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD1yLkG2Olkh|ryP NHXmc4FUSU6JRWK=
SCC-9 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnBeplFUUN3ME2wMlE3PzF4IN88US=> NYHjNlZZW0GQR1XS
HT-1376 NUjjPFZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjWSnpYUUN3ME2wMlE3QTN4IN88US=> Ml7DV2FPT0WU
U-2-OS NHnLWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fUfmlEPTB;MD6xO|E4OyEQvF2= MkPUV2FPT0WU
COLO-824 M1nO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvRdmZKSzVyPUCuNVczQTRizszN M{HJV3NCVkeHUh?=
BB30-HNC NYjYOIRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH5RpVKSzVyPUCuNVc{OyEQvF2= Mn\vV2FPT0WU
NCI-H2087 NF2wbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGyXWpWUUN3ME2wMlE4OzZ6IN88US=> NGezZ4FUSU6JRWK=
NCI-H2170 NIf3ZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS0TWM2OD1yLkG3OVM3KM7:TR?= NIXxUGdUSU6JRWK=
SK-OV-3 NWTqfVVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH2VG1tUUN3ME2wMlE4PTdzIN88US=> NUjZe45ZW0GQR1XS
MZ7-mel MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33TR2lEPTB;MD6xO|Y1QSEQvF2= MVvTRW5ITVJ?
NCI-H650 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT1U3ZKSzVyPUCuNVc3QDJizszN NV7TXZBoW0GQR1XS
KOSC-2 NEfqOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrSR3RKSzVyPUCuNVc4OzRizszN MmXoV2FPT0WU
SCC-4 M4WxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCwTWM2OD1yLkG3O|c4KM7:TR?= NYPJZWRbW0GQR1XS
MDA-MB-157 NIS3R29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\ReVZxUUN3ME2wMlE5ODh{IN88US=> NGjCenBUSU6JRWK=
KYSE-520 M{jtNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXubo5pUUN3ME2wMlE5OiEQvF2= NIPNflhUSU6JRWK=
LK-2 NFXue5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XpfmlEPTB;MD6xPFMxOyEQvF2= M1v5bnNCVkeHUh?=
KNS-81-FD MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjEeIJKSzVyPUCuNVg{QTRizszN NHHOTZFUSU6JRWK=
IGROV-1 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq1[5BKSzVyPUCuNVg1PDNizszN MXLTRW5ITVJ?
DEL Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDEdlhCUUN3ME2wMlE5PDVizszN MX3TRW5ITVJ?
NCI-H1395 NELTbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMUi2PFIh|ryP NFjENlVUSU6JRWK=
JEG-3 NEDXS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n0OmlEPTB;MD6xPFcxPSEQvF2= M4LSWXNCVkeHUh?=
BCPAP MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HyPWlEPTB;MD6xPFg4OiEQvF2= MlzmV2FPT0WU
CAL-27 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;qZ2hKSzVyPUCuNVkxOjJizszN M4[2fHNCVkeHUh?=
RD NIf4SI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUmxNVMh|ryP M4TROXNCVkeHUh?=
RVH-421 NHmwOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLIOpo1UUN3ME2wMlE6OTF4IN88US=> NYjqTpF4W0GQR1XS
Capan-2 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrJZZlpUUN3ME2wMlE6OjV4IN88US=> NXXMZolYW0GQR1XS
COLO-680N MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XhbmlEPTB;MD6xPVM3PCEQvF2= MWjTRW5ITVJ?
NCI-H1650 MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMkCwOVch|ryP M2jsVXNCVkeHUh?=
SBC-5 NYnkUJhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMkCxNVgh|ryP MVTTRW5ITVJ?
U031 NFfi[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDxPG5iUUN3ME2wMlIxPTR5IN88US=> M2raV3NCVkeHUh?=
S-117 M1e4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX6XVRKSzVyPUCuNlA2PjRizszN Mn3jV2FPT0WU
DoTc2-4510 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fBXGlEPTB;MD6yNFc3QSEQvF2= NVHCOolLW0GQR1XS
AM-38 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMkC4OFgh|ryP NVj4VJdJW0GQR1XS
A172 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjtOW83UUN3ME2wMlIyODJ{IN88US=> MVXTRW5ITVJ?
HPAF-II NXjHTldjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMkGyOlQh|ryP M1v2OnNCVkeHUh?=
769-P MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M362[GlEPTB;MD6yNVI5KM7:TR?= M3XqO3NCVkeHUh?=
MFE-280 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjlO2xjUUN3ME2wMlIyOjl6IN88US=> MX7TRW5ITVJ?
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NCI-H1155 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXXcIlOUUN3ME2wMlI3OTZ{IN88US=> M3foPHNCVkeHUh?=
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NCI-H2405 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13WTmlEPTB;MD6zOFY{OSEQvF2= M4TyTHNCVkeHUh?=
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PANC-08-13 NHW5N4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTWPHZlUUN3ME2wMlU{OTd5IN88US=> NWfGcpN7W0GQR1XS
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MSTO-211H MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNUW3OlIh|ryP NF7Nco5USU6JRWK=
NCI-H2126 NH[2b41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwNU[4NVUh|ryP MlfKV2FPT0WU
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DBTRG-05MG NGLLOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwNUiwOVMh|ryP MYrTRW5ITVJ?
MKN1 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmriTWM2OD1yLkW4O|g{KM7:TR?= NV;yWJRzW0GQR1XS
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OVCAR-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LnTmlEPTB;MD61PVM1OSEQvF2= NInFNVdUSU6JRWK=
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CP66-MEL M4DnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jVdWlEPTB;MD62NFk3QSEQvF2= NV7zZ40{W0GQR1XS
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UACC-893 NVPyUVJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNkO2PFEh|ryP NXizepVSW0GQR1XS
JVM-3 NH;X[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwNkO4NFQh|ryP MlrlV2FPT0WU
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RPMI-8226 NXXmdo5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPxd3dKSzVyPUCuOlY{OjNizszN M37udXNCVkeHUh?=
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MDA-MB-453 NFTIdWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LqbWlEPTB;MD62O|E5KM7:TR?= NHnMbXdUSU6JRWK=
BV-173 NF3HbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD6TZA5UUN3ME2wMlY5Pjd7IN88US=> MW\TRW5ITVJ?
NCI-H358 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwNki3NlYh|ryP NUXlR5JmW0GQR1XS
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EFM-19 MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfndYZ[UUN3ME2wMlc{PjdzIN88US=> NWPHVYVNW0GQR1XS
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UACC-257 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwOEKyN|Eh|ryP MWXTRW5ITVJ?
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NCI-H2009 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTLc4ZKSzVyPUCuPFU{OTFizszN M1S5SnNCVkeHUh?=
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NCI-H2052 NFHBSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr5cZg{UUN3ME2xMlMxPTB5IN88US=> NYHydWx7W0GQR1XS
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NCI-H596 NWHqbmE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwNEWwOlEh|ryP NGnOV5BUSU6JRWK=
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SW1417 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ydZVDUUN3ME2xMlczQDR7IN88US=> NV\vbXpkW0GQR1XS
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NCI-H209 NFTxPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDBTWM2OD12LkK5PVk6KM7:TR?= M1jBfXNCVkeHUh?=
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HLE Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XJc2lEPTB;MUKuPFIyPSEQvF2= MYjTRW5ITVJ?
RCC10RGB NH;DdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoKxTWM2OD1zMz62O|Eh|ryP NVPR[4tPW0GQR1XS
COLO-320-HSR NETEN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDLUJNiUUN3ME2xN{44OzhzIN88US=> MVzTRW5ITVJ?
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MEG-01 M1nXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF2LkO3NFgh|ryP MWnTRW5ITVJ?
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SW1116 M1vh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjScYFpUUN3ME2yNE46OzZ{IN88US=> M{DpOnNCVkeHUh?=
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D-502MG M4DlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M160bmlEPTB;MkKuPFI3OSEQvF2= Mlq5V2FPT0WU
IA-LM Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Hpb2lEPTB;MkOuNlQ6OyEQvF2= M1zjRXNCVkeHUh?=
SW1463 NV6yUmxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\JWWVKSzVyPUKzMlc6KM7:TR?= M4q3XXNCVkeHUh?=
JAR NXrlTYRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nTRmlEPTB;MkSuN|I6OyEQvF2= NGq4bpRUSU6JRWK=
HT MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7a[5BKSzVyPUK0MlQ4PTNizszN NGHifWZUSU6JRWK=
LCLC-103H Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETuO4VKSzVyPUK0Mlg1PDlizszN MlKyV2FPT0WU
SNU-449 M1f1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ2Lki3OFEh|ryP NYjZcoVbW0GQR1XS
KE-37 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1{NT6wPVI5KM7:TR?= MnTTV2FPT0WU
NCI-H1623 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnhOXBlUUN3ME2yO{4yOzB|IN88US=> NIDpNnlUSU6JRWK=
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NB6 NYfDO4l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO5TWM2OD1|Mj6yPFc3KM7:TR?= NIPu[2hUSU6JRWK=
MOLT-16 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjPWY1YUUN3ME2zN{4xODV3IN88US=> M3rYeHNCVkeHUh?=
IST-MES1 NXPkfGgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHFPIZNUUN3ME2zOE4xPTRzIN88US=> NH7nWHpUSU6JRWK=
A4-Fuk NFizZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq0WWpKSzVyPUO1MlA3PiEQvF2= MkDwV2FPT0WU
CAL-85-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXUTWM2OD1|NT6yPFE4KM7:TR?= NILkeZNUSU6JRWK=
CCRF-CEM NWPBV3BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN5LkG1N|Yh|ryP NHu3bG9USU6JRWK=
HAL-01 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTN6LkS4PFkh|ryP MoS1V2FPT0WU
HEL Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XodWlEPTB;NEOuN|QxQSEQvF2= MWPTRW5ITVJ?
EW-1 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[z[3NrUUN3ME20N{41PzZ6IN88US=> MYXTRW5ITVJ?
MDA-MB-231 NYHUZmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTR3LkGxPVkh|ryP M13ZVHNCVkeHUh?=
ABC-1 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f6UmlEPTB;NE[uPFU{QCEQvF2= M3TTfnNCVkeHUh?=
NCI-H446 NFvySZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTR6LkWwOVgh|ryP MUTTRW5ITVJ?
MHH-PREB-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPJPYFKSzVyPUS5MlYxODdizszN M3jUU3NCVkeHUh?=
DOHH-2 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonZTWM2OD12OT62OlU3KM7:TR?= NEXHO2NUSU6JRWK=
GCT MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTR7Lk[5O|Yh|ryP MYTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
in solvent
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • Answer:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID