Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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Cited by 20 Publications

9 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMECwN|A{KM7:TR?= NGjtW2pUSU6JRWK=
IST-MEL1 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLWTWM2OD1yLkCwNFQxPyEQvF2= M3nRXXNCVkeHUh?=
NCI-SNU-1 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjZTHJKSzVyPUCuNFAzODdizszN NH7qSIVUSU6JRWK=
FADU M3rUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HnSmlEPTB;MD6wNFIxQSEQvF2= NF;BdIlUSU6JRWK=
C32 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17iPWlEPTB;MD6wNFMxPCEQvF2= MXPTRW5ITVJ?
D-566MG NYHOZWF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vsdGlEPTB;MD6wNFM6KM7:TR?= Mo\wV2FPT0WU
LXF-289 NInWR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PoNWlEPTB;MD6wNFQyQSEQvF2= NGj4VpVUSU6JRWK=
HGC-27 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Hub2lEPTB;MD6wNFUyKM7:TR?= MkXSV2FPT0WU
RPMI-7951 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rNU2lEPTB;MD6wNFcyPyEQvF2= MYDTRW5ITVJ?
HSC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\wNGxtUUN3ME2wMlAxQTJ7IN88US=> NE\KfnRUSU6JRWK=
MIA-PaCa-2 M4foU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPBTWM2OD1yLkCxNFA6KM7:TR?= M1u2c3NCVkeHUh?=
KS-1 MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jKPWlEPTB;MD6wNVM2PSEQvF2= MmDYV2FPT0WU
CAL-51 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzxTWM2OD1yLkCxOFA2KM7:TR?= MofZV2FPT0WU
MDA-MB-361 M2\6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknTTWM2OD1yLkCxOFk2KM7:TR?= NWfJZndJW0GQR1XS
TI-73 NU\0WoJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK5TWM2OD1yLkCxO|k3KM7:TR?= MV;TRW5ITVJ?
AGS NGfEZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ZTWM2OD1yLkCxPVM5KM7:TR?= MY\TRW5ITVJ?
NCI-H460 NFPtV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HscGlEPTB;MD6wNVk4PCEQvF2= NXHQcpd{W0GQR1XS
A204 NIPQN4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjXcFlyUUN3ME2wMlAzOjR7IN88US=> NXPsVZZwW0GQR1XS
CHL-1 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX5b3hKSzVyPUCuNFIzPTFizszN M3rNN3NCVkeHUh?=
DU-4475 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Ty[WlEPTB;MD6wNlI3OSEQvF2= M3;UbXNCVkeHUh?=
CGTH-W-1 NGrheYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7TTWM2OD1yLkCyN|Q6KM7:TR?= NXzmTlltW0GQR1XS
HCC2218 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rVWmlEPTB;MD6wNlQ6PCEQvF2= NHW3cHhUSU6JRWK=
A2780 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOwTWM2OD1yLkCyOVMyKM7:TR?= M2TYNXNCVkeHUh?=
NCI-H720 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Lie2lEPTB;MD6wNlU1PiEQvF2= NF;2bZhUSU6JRWK=
NCI-N87 NWiwPW5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorCTWM2OD1yLkCyOVk{KM7:TR?= NITHcnNUSU6JRWK=
CHP-212 NGHqNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEK2Nlgh|ryP MofwV2FPT0WU
NCI-H23 NVzPRVltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEK2OlUh|ryP NInX[lFUSU6JRWK=
D-263MG NGG3NYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlviTWM2OD1yLkCyO|g3KM7:TR?= MXXTRW5ITVJ?
ME-180 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7xcGVKSzVyPUCuNFI5QTFizszN MWnTRW5ITVJ?
SW982 M3K0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\PTWM2OD1yLkCyPVk6KM7:TR?= NXTvZ4VYW0GQR1XS
OE19 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLIVG53UUN3ME2wMlA{ODd5IN88US=> MYDTRW5ITVJ?
SK-LU-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHETWM2OD1yLkCzNFgzKM7:TR?= M17UNHNCVkeHUh?=
H4 NYqxVHNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjkZXpKSzVyPUCuNFMxQSEQvF2= NUDEUpM{W0GQR1XS
HT-144 Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NICxc2tKSzVyPUCuNFMxQTNizszN Ml30V2FPT0WU
SK-UT-1 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfXTWM2OD1yLkCzNVc5KM7:TR?= NWmzVoVLW0GQR1XS
D-336MG NX3JOXdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1yLkCzN|A6KM7:TR?= MUHTRW5ITVJ?
MDA-MB-175-VII M1P1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXmWZJCUUN3ME2wMlA{OzV2IN88US=> M{fEb3NCVkeHUh?=
GAMG M365Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HCSGlEPTB;MD6wN|Q{PSEQvF2= M3LybnNCVkeHUh?=
CP50-MEL-B MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3OXlKSzVyPUCuNFM1PSEQvF2= MUjTRW5ITVJ?
OVCAR-5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXFW4NzUUN3ME2wMlA{PDhizszN MYjTRW5ITVJ?
SK-MES-1 M3vWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLk[WxKSzVyPUCuNFM3ODZizszN MnjUV2FPT0WU
VM-CUB-1 NYKyZno3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnxTWM2OD1yLkCzOlU4KM7:TR?= MYTTRW5ITVJ?
WM-115 NELGcWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEO3OlIh|ryP NXXON3pSW0GQR1XS
DSH1 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nHVGlEPTB;MD6wN|gxPyEQvF2= MVHTRW5ITVJ?
Becker M2LjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml23TWM2OD1yLkCzPFg2KM7:TR?= MlPPV2FPT0WU
SW962 NXi2XnJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHBTWM2OD1yLkCzPVQ2KM7:TR?= M1LQOnNCVkeHUh?=
TYK-nu MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO5PFUh|ryP M1rHZ3NCVkeHUh?=
HO-1-N-1 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnFXY5XUUN3ME2wMlA1ODJzIN88US=> NFLGUWtUSU6JRWK=
T98G M16yNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G3OWlEPTB;MD6wOFExOyEQvF2= NWjReVFVW0GQR1XS
ACN MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDTTWM2OD1yLkC0NVYzKM7:TR?= NWC3OldIW0GQR1XS
SW780 NEL6WldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXnTWM2OD1yLkC0NlA{KM7:TR?= M1;wU3NCVkeHUh?=
Detroit562 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC5TnNKSzVyPUCuNFQzOzlizszN M3jZTHNCVkeHUh?=
BB49-HNC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX1XXlKSzVyPUCuNFQzPDNizszN Mn\WV2FPT0WU
HN M{TtVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMESyO|Ih|ryP M3jR[HNCVkeHUh?=
H9 NUfSeY5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD4fGdKSzVyPUCuNFQ{PzFizszN NUjqbYlWW0GQR1XS
VA-ES-BJ MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzwTWM2OD1yLkC0OFQ4KM7:TR?= MWLTRW5ITVJ?
MEL-JUSO M2\WZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMES0O|Uh|ryP MX3TRW5ITVJ?
BT-474 NG\TbmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z2OGlEPTB;MD6wOFUh|ryP MXPTRW5ITVJ?
CaR-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyyTWM2OD1yLkC0OVQ6KM7:TR?= M1TUdnNCVkeHUh?=
PSN1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTz[2hKSzVyPUCuNFQ3ODNizszN NWW1R5ZvW0GQR1XS
KYSE-510 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPxR|RWUUN3ME2wMlA1PjR7IN88US=> NYXlOJVHW0GQR1XS
KP-4 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonuTWM2OD1yLkC0O|U{KM7:TR?= M1q2NXNCVkeHUh?=
KYSE-410 M1K2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTqUFNKSzVyPUCuNFQ4PzJizszN M{G3RnNCVkeHUh?=
G-402 NVfHOJpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMES3PFkh|ryP MUPTRW5ITVJ?
DOK NIHtd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMES5NFIh|ryP MnPaV2FPT0WU
COR-L88 M{jEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMES5NVIh|ryP M1S0bHNCVkeHUh?=
SKG-IIIa NXjRTVlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFewN2dKSzVyPUCuNFQ6QDZizszN MnrIV2FPT0WU
AN3-CA M3PRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TFRWlEPTB;MD6wOUDPxE1? MYfTRW5ITVJ?
SW48 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID3T5JKSzVyPUCuNFUxOzlizszN NVTQeG5GW0GQR1XS
YKG-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu4dVNKSzVyPUCuNFUxPzFizszN M{PyZ3NCVkeHUh?=
KYSE-150 NUfESnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GxemlEPTB;MD6wOVI{PSEQvF2= MnTtV2FPT0WU
HuO-3N1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXXTWM2OD1yLkC1NlM4KM7:TR?= MWjTRW5ITVJ?
LB1047-RCC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLDTWM2OD1yLkC1Nlk3KM7:TR?= NXLnXnNIW0GQR1XS
NCI-H2030 M2C2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLwTWM2OD1yLkC1OFE1KM7:TR?= MmnlV2FPT0WU
YH-13 NFGxfGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEW3NlIh|ryP NF73XodUSU6JRWK=
5637 NXni[mV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX35RoRDUUN3ME2wMlA2PzRizszN MX7TRW5ITVJ?
LOXIMVI MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjteoxKSzVyPUCuNFU5PzJizszN NV2xOmpOW0GQR1XS
GT3TKB MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi2TWM2OD1yLkC1PVQzKM7:TR?= NV7kbYlDW0GQR1XS
TCCSUP MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEW5OlQh|ryP NWrzVmN{W0GQR1XS
EPLC-272H M3TKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[wTWM2OD1yLkC2NlA2KM7:TR?= M3PURXNCVkeHUh?=
LU-99A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwME[yN|ch|ryP NFnsXYFUSU6JRWK=
NCI-H1755 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmwXWxVUUN3ME2wMlA3OzRzIN88US=> NWrCPGRTW0GQR1XS
KM12 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7BSIE6UUN3ME2wMlA3OzR6IN88US=> NVjRNIdVW0GQR1XS
SF295 NVOzfm9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTRTWM2OD1yLkC2OFUzKM7:TR?= NFK3SIJUSU6JRWK=
MZ2-MEL NFu5UW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwME[1OVMh|ryP MYPTRW5ITVJ?
HEC-1 NFOxPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MliwTWM2OD1yLkC2OVg5KM7:TR?= MnvrV2FPT0WU
SW684 NGDqNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj4TWM2OD1yLkC2OVkyKM7:TR?= NWTVT|RsW0GQR1XS
SF539 NYfh[nBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwME[2PFEh|ryP MX\TRW5ITVJ?
GMS-10 NWPVfmNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\UUItZUUN3ME2wMlA3Pjl7IN88US=> MmS5V2FPT0WU
MV-4-11 NIrDfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwME[4NFMh|ryP Mn;FV2FPT0WU
HT-29 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnpXpRKSzVyPUCuNFY6OTlizszN NYGwbI9JW0GQR1XS
23132-87 NULYOJp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzqTWM2OD1yLkC2PVUh|ryP MWLTRW5ITVJ?
SW620 NYroXoNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTkcmk6UUN3ME2wMlA4ODJ4IN88US=> MVPTRW5ITVJ?
HCC1806 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP5TWM2OD1yLkC3NVMyKM7:TR?= M2DOSHNCVkeHUh?=
Hs-578-T MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfhbWtKSzVyPUCuNFczODhizszN M2jSNXNCVkeHUh?=
A2058 NEjrNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2izfWlEPTB;MD6wO|IzQCEQvF2= Mn7yV2FPT0WU
MEL-HO M4jRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHBTmtiUUN3ME2wMlA4OjV3IN88US=> M3TuR3NCVkeHUh?=
HCC2998 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzzUZJKSzVyPUCuNFc{PDdizszN NH7TRm5USU6JRWK=
HuO9 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEe1PFkh|ryP M4DkdHNCVkeHUh?=
CAL-39 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEe3OlYh|ryP M17EWHNCVkeHUh?=
M14 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED6T4FKSzVyPUCuNFc6OTNizszN M3;QNXNCVkeHUh?=
BFTC-909 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\GTWM2OD1yLkC3PVY6KM7:TR?= MYrTRW5ITVJ?
TE-11 NF3iSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHOPFl5UUN3ME2wMlA4QTl4IN88US=> M2PKNHNCVkeHUh?=
TGBC1TKB NV;WSHlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEiwOFMh|ryP NHXvNYlUSU6JRWK=
L-363 M13jdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT1TWM2OD1yLkC4NlA3KM7:TR?= MmexV2FPT0WU
A431 Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEiyNUDPxE1? MWfTRW5ITVJ?
MKN45 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEiyNVkh|ryP M1nYb3NCVkeHUh?=
HT-1080 M4PJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnabXBKSzVyPUCuNFg1OzlizszN M{L0THNCVkeHUh?=
OVCAR-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33TOmlEPTB;MD6wPFYzOiEQvF2= NXvEO5pFW0GQR1XS
LCLC-97TM1 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEi3Nlgh|ryP NEjqOW5USU6JRWK=
M059J NXjO[Fd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEmwNlch|ryP MnntV2FPT0WU
SK-MEL-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEmwOkDPxE1? NITScWNUSU6JRWK=
TE-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3xTWM2OD1yLkC5NlA1KM7:TR?= MnLYV2FPT0WU
KYSE-180 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXEcXVzUUN3ME2wMlA6OjZ{IN88US=> M4O3eHNCVkeHUh?=
D-247MG NXq4cZlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr5TWM2OD1yLkC5OFU2KM7:TR?= M{fjUnNCVkeHUh?=
8-MG-BA NXO2V2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPWOWFKSzVyPUCuNFk1PzJizszN M3\0b3NCVkeHUh?=
NCI-H1792 M2jzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzzXZpKSzVyPUCuNFk3OThizszN MnL3V2FPT0WU
MCF7 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3SzN2lEPTB;MD6wPVY4PyEQvF2= M2L6UHNCVkeHUh?=
NCI-H2122 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33uSGlEPTB;MD6wPVc1PSEQvF2= MV3TRW5ITVJ?
EFO-27 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:zd2lEPTB;MD6wPVk6PyEQvF2= NXXDbmtRW0GQR1XS
LB2241-RCC NVvkN2xST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWmxS5N3UUN3ME2wMlExODV2IN88US=> MnHGV2FPT0WU
SN12C MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nFSmlEPTB;MD6xNFExPyEQvF2= NVHiW|NJW0GQR1XS
A498 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXjbVR2UUN3ME2wMlExOThizszN NGrqb|BUSU6JRWK=
PANC-03-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof0TWM2OD1yLkGwNlg3KM7:TR?= M2TISnNCVkeHUh?=
NCI-H1581 M3zqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzCdHpwUUN3ME2wMlExOjlizszN Mn\0V2FPT0WU
U-87-MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMUCzNFch|ryP MY\TRW5ITVJ?
G-401 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMUCzOVMh|ryP Mlf2V2FPT0WU
SiHa NV\Wb4ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHmdldKSzVyPUCuNVA1QDZizszN MkDkV2FPT0WU
U251 NE[1W2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDES4toUUN3ME2wMlExPTJ3IN88US=> NX:2epRQW0GQR1XS
MMAC-SF MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMUC1N|Eh|ryP MlP6V2FPT0WU
BB65-RCC MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPGS4V{UUN3ME2wMlExPTV2IN88US=> NYf4T|ZlW0GQR1XS
NKM-1 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHKVJJ7UUN3ME2wMlExPjZ4IN88US=> M1[we3NCVkeHUh?=
HD-MY-Z MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUC4O|Mh|ryP MoPMV2FPT0WU
TGBC11TKB NFPMd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zIZ2lEPTB;MD6xNFkxOyEQvF2= MlvqV2FPT0WU
COLO-679 NF;5TldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDSZolWUUN3ME2wMlEyOjFzIN88US=> MWPTRW5ITVJ?
TE-8 NX7sZlcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMUGyOlQh|ryP MmK0V2FPT0WU
SK-MEL-28 NITwRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG3TWM2OD1yLkGxN|IyKM7:TR?= MV\TRW5ITVJ?
SH-4 M1X1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3mTWM2OD1yLkGxN|U3KM7:TR?= M3nE[HNCVkeHUh?=
KALS-1 NV2wb2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTBWJBGUUN3ME2wMlEyOzl|IN88US=> MkPyV2FPT0WU
RKO M37zZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUG3OlQh|ryP MYLTRW5ITVJ?
OMC-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLHU2JKSzVyPUCuNVE4QTdizszN NGPiSHZUSU6JRWK=
BT-549 M3nLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnsSYJKSzVyPUCuNVE4QTlizszN M13sPXNCVkeHUh?=
NCI-H28 MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGzSZBDUUN3ME2wMlEyQDF5IN88US=> NFvQXWxUSU6JRWK=
RXF393 M4fGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv6TWM2OD1yLkGxPVgzKM7:TR?= NXXuZ|doW0GQR1XS
COLO-829 M164OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLZTWM2OD1yLkGyNFA2KM7:TR?= NV7mfVE2W0GQR1XS
HMV-II M3zoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jaTGlEPTB;MD6xNlAzKM7:TR?= NWLhXI86W0GQR1XS
SW1990 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMUKxOVch|ryP NHPvb4xUSU6JRWK=
NCI-H1437 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fNemlEPTB;MD6xNlE2PyEQvF2= M{jaVnNCVkeHUh?=
SNB75 NWXXR|hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2qzWGlEPTB;MD6xNlE3QSEQvF2= Ml2zV2FPT0WU
EW-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMUK2OlEh|ryP NG\0cWlUSU6JRWK=
SAS NIX0WIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMUK2PUDPxE1? MVfTRW5ITVJ?
NCI-H1666 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMUK3O|Qh|ryP M2X2UnNCVkeHUh?=
A375 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P1R2lEPTB;MD6xNlc4QCEQvF2= M1jMOXNCVkeHUh?=
CAMA-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTlTWM2OD1yLkGyPVI1KM7:TR?= M1iwXnNCVkeHUh?=
HuP-T4 NW[4XGVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUK5OFMh|ryP MVLTRW5ITVJ?
NCI-H292 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMUOxNUDPxE1? M3jK[HNCVkeHUh?=
PC-14 NF3CSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XoO2lEPTB;MD6xN|IyOSEQvF2= MV3TRW5ITVJ?
BPH-1 NIrZ[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\uUmhXUUN3ME2wMlE{PDFizszN M1PtdXNCVkeHUh?=
GAK MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD6TWM2OD1yLkGzOVY4KM7:TR?= NIjDU|dUSU6JRWK=
VMRC-RCZ NELaVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ITWM2OD1yLkGzO|YzKM7:TR?= MV3TRW5ITVJ?
SK-MEL-24 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;zN|lwUUN3ME2wMlE{QDdizszN NHPoXo1USU6JRWK=
LB831-BLC NIPOWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMUO4PFMh|ryP MX3TRW5ITVJ?
NCI-H2452 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G4d2lEPTB;MD6xN|k2PiEQvF2= Mn\sV2FPT0WU
RT-112 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPuVldDUUN3ME2wMlE1ODN3IN88US=> M2TGeHNCVkeHUh?=
GP5d MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnJeZNKSzVyPUCuNVQyODRizszN MkSxV2FPT0WU
LC-2-ad NFXHN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPYTWM2OD1yLkG0NVIyKM7:TR?= NUnGVYJpW0GQR1XS
MPP-89 NXnBdGJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe4[3NKSzVyPUCuNVQyOjVizszN NWG3dYRGW0GQR1XS
NUGC-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK3ZVZKSzVyPUCuNVQ1PzhizszN NVnQVGd[W0GQR1XS
GI-1 M{i4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3niWGlEPTB;MD6xOFU2QCEQvF2= M4qxenNCVkeHUh?=
HCC1419 NX\K[4FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMUS1O|Yh|ryP MnrHV2FPT0WU
SW1573 NGXVdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUS3OVgh|ryP MY\TRW5ITVJ?
NCI-H2347 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG3VnhKSzVyPUCuNVQ5OzlizszN NYHDO5c2W0GQR1XS
Mewo M{PDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPxOlhKSzVyPUCuNVQ5QDlizszN MX3TRW5ITVJ?
639-V M1nC[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUWwNVMh|ryP NVLjSHNYW0GQR1XS
AsPC-1 NFnZcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHLeXd2UUN3ME2wMlE2OjJ3IN88US=> NXXxUYhvW0GQR1XS
NCI-H1648 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUWyN|Ih|ryP NYrKcI1xW0GQR1XS
786-0 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUWzPFEh|ryP M3qzV3NCVkeHUh?=
ETK-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;5dGlEPTB;MD6xOVkh|ryP NYHNWm9pW0GQR1XS
BxPC-3 M32weWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUW5OlYh|ryP Mmf5V2FPT0WU
CAL-62 NGX3NnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ONXgzUUN3ME2wMlE3OTZ7IN88US=> NYjxOXRWW0GQR1XS
HCC1937 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\U[GlEPTB;MD6xOlI4PSEQvF2= MV;TRW5ITVJ?
NCI-H1299 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPxTWM2OD1yLkG2Nlg2KM7:TR?= NGPIXVNUSU6JRWK=
SW1088 M{K5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMU[0NVMh|ryP MWXTRW5ITVJ?
FTC-133 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\uTWM2OD1yLkG2OVQh|ryP Ml\WV2FPT0WU
OC-314 MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMU[2PUDPxE1? NFj3PFJUSU6JRWK=
SCC-9 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPEXI9pUUN3ME2wMlE3PzF4IN88US=> M{HGRnNCVkeHUh?=
HT-1376 M2P5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPDTWM2OD1yLkG2PVM3KM7:TR?= M2jHO3NCVkeHUh?=
U-2-OS NVr1NJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOwTWM2OD1yLkG3NVc{KM7:TR?= MnzlV2FPT0WU
COLO-824 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TPVWlEPTB;MD6xO|I6PCEQvF2= NH7iVlBUSU6JRWK=
BB30-HNC NI\sbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vpZWlEPTB;MD6xO|M{KM7:TR?= NXPCZZFGW0GQR1XS
NCI-H2087 M3rafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMUezOlgh|ryP NV[ye4Q3W0GQR1XS
NCI-H2170 NWfpeI1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLqTWM2OD1yLkG3OVM3KM7:TR?= M2f5OHNCVkeHUh?=
SK-OV-3 M{PwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;xTWM2OD1yLkG3OVcyKM7:TR?= NUjHS3FYW0GQR1XS
MZ7-mel MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HERWlEPTB;MD6xO|Y1QSEQvF2= NUjYdZAxW0GQR1XS
NCI-H650 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwSWlEPTB;MD6xO|Y5OiEQvF2= MWHTRW5ITVJ?
KOSC-2 NETJZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnQWpdkUUN3ME2wMlE4PzN2IN88US=> NYfnNJhUW0GQR1XS
SCC-4 M1XxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDpWoRFUUN3ME2wMlE4Pzd5IN88US=> M2nKOnNCVkeHUh?=
MDA-MB-157 M2PSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofITWM2OD1yLkG4NFgzKM7:TR?= MULTRW5ITVJ?
KYSE-520 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTzTWM2OD1yLkG4NkDPxE1? NXXUOHpwW0GQR1XS
LK-2 NGjwPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknnTWM2OD1yLkG4N|A{KM7:TR?= NHzNOXpUSU6JRWK=
KNS-81-FD MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMUizPVQh|ryP NXGzcHBDW0GQR1XS
IGROV-1 MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGxTWM2OD1yLkG4OFQ{KM7:TR?= M3jqWXNCVkeHUh?=
DEL NWG0Z2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMUi0OUDPxE1? NXLCN|RzW0GQR1XS
NCI-H1395 Mni3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET4XlFKSzVyPUCuNVg3QDJizszN M33l[nNCVkeHUh?=
JEG-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n6b2lEPTB;MD6xPFcxPSEQvF2= MWfTRW5ITVJ?
BCPAP M2HTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW4[2FKSzVyPUCuNVg5PzJizszN M4\4TnNCVkeHUh?=
CAL-27 NUC2dGd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMUmwNlIh|ryP MnzJV2FPT0WU
RD M2\OdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMUmxNVMh|ryP NXrLS3JIW0GQR1XS
RVH-421 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3mdG1jUUN3ME2wMlE6OTF4IN88US=> NEHyTmxUSU6JRWK=
Capan-2 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMUmyOVYh|ryP M1\PZXNCVkeHUh?=
COLO-680N M1nUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2xSHgyUUN3ME2wMlE6OzZ2IN88US=> NIq1UnBUSU6JRWK=
NCI-H1650 M2O0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:4TY4xUUN3ME2wMlIxODV5IN88US=> M2HE[nNCVkeHUh?=
SBC-5 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXt[G1KSzVyPUCuNlAyOThizszN NHXnfWFUSU6JRWK=
U031 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H4bmlEPTB;MD6yNFU1PyEQvF2= M1nVNHNCVkeHUh?=
S-117 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ZO2lEPTB;MD6yNFU3PCEQvF2= MoDrV2FPT0WU
DoTc2-4510 M1nqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;vOGlEPTB;MD6yNFc3QSEQvF2= MYXTRW5ITVJ?
AM-38 M163e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMkC4OFgh|ryP MonuV2FPT0WU
A172 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrN[odKSzVyPUCuNlExOjJizszN NHvMbotUSU6JRWK=
HPAF-II M3voRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TGcmlEPTB;MD6yNVI3PCEQvF2= MlzRV2FPT0WU
769-P MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjLdHpKSzVyPUCuNlEzQCEQvF2= Mlf6V2FPT0WU
MFE-280 NEjsOYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLUTWM2OD1yLkKxNlk5KM7:TR?= NXnJVo1pW0GQR1XS
TE-9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TrRmlEPTB;MD6yNVc5PiEQvF2= NWD6cIppW0GQR1XS
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Ca-Ski NUj2V|FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPFfmJ2UUN3ME2wMlI3Pjd6IN88US=> M1vqPXNCVkeHUh?=
SBC-1 NYHhfGZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnYW5o2UUN3ME2wMlI3PzR{IN88US=> NV\ReWx5W0GQR1XS
NB69 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT0[FFRUUN3ME2wMlI4ODh5IN88US=> NXLuTm9yW0GQR1XS
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NCI-H1048 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMki5OVYh|ryP MWHTRW5ITVJ?
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UACC-62 NFfqOXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJ[I1KSzVyPUCuN|IzOjdizszN MXfTRW5ITVJ?
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DMS-273 NXvJRZV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3yTFExUUN3ME2wMlM{QTF4IN88US=> MYPTRW5ITVJ?
SW1783 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrnW3RKSzVyPUCuN|M6QTdizszN M3;USXNCVkeHUh?=
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HSC-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCeYtyUUN3ME2wMlM1ODV|IN88US=> MWPTRW5ITVJ?
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COLO-684 M2jHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwM{S1NFEh|ryP M4G1PHNCVkeHUh?=
NCI-H2405 NF7pRmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\wTWM2OD1yLkO0OlMyKM7:TR?= NUnldpI1W0GQR1XS
NCI-H2228 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK2TWM2OD1yLkO1N|U4KM7:TR?= MlfkV2FPT0WU
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DK-MG NGDnOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwM{exPFgh|ryP NFvtTI9USU6JRWK=
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NCI-H1793 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPOPWpoUUN3ME2wMlM5PTFizszN M{f3OHNCVkeHUh?=
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HCC2157 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwM{i3PFEh|ryP MlfaV2FPT0WU
EW-18 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ewT2lEPTB;MD6zPFk1OSEQvF2= NUnkWpV2W0GQR1XS
RO82-W-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLLb5BKSzVyPUCuN|k3QTlizszN NFjoWo5USU6JRWK=
HuP-T3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTkXJFrUUN3ME2wMlQxOTR|IN88US=> NGjmdW9USU6JRWK=
PANC-10-05 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ra[2lEPTB;MD60NVE4KM7:TR?= MYXTRW5ITVJ?
NCI-H1703 NXGzUI45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi0T2dKSzVyPUCuOFE1PDZizszN NWXlO4pZW0GQR1XS
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HOS MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DhcGlEPTB;MD60NVY5OiEQvF2= M4jpOXNCVkeHUh?=
LN-405 NXi2b5FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;veINLUUN3ME2wMlQyPjh5IN88US=> MUTTRW5ITVJ?
A427 NFzD[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH1TYhzUUN3ME2wMlQyQThzIN88US=> MmT4V2FPT0WU
CAL-12T MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ruXGlEPTB;MD60Nlc5KM7:TR?= MXvTRW5ITVJ?
SW756 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNESxPFMh|ryP M2jmPXNCVkeHUh?=
YAPC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjuZpNKSzVyPUCuOFUxQCEQvF2= NFTBW4ZUSU6JRWK=
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NCI-H1573 M3naVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnqVWNvUUN3ME2wMlQ2PTZ7IN88US=> M{\scnNCVkeHUh?=
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COR-L23 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXaUoJKSzVyPUCuOFY4PjRizszN NE\nUVBUSU6JRWK=
HCE-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjxU2VsUUN3ME2wMlQ4PDR4IN88US=> MnTWV2FPT0WU
NCI-H2291 NIHhdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwNEe4PVYh|ryP M4HpSnNCVkeHUh?=
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HT-3 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HZZWlEPTB;MD60PFIyPyEQvF2= MYXTRW5ITVJ?
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PC-3 NHfjVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrzd25KSzVyPUCuOVE2ODdizszN MmrsV2FPT0WU
CTV-1 M2fNb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDPcVVQUUN3ME2wMlUzPjZ7IN88US=> MVvTRW5ITVJ?
PANC-08-13 M4rWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\ETWM2OD1yLkWzNVc4KM7:TR?= MnjXV2FPT0WU
CAL-120 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\mXmlEPTB;MD61N|M6QSEQvF2= NIDnblJUSU6JRWK=
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MSTO-211H NVz1TnlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fF[mlEPTB;MD61OVc3OiEQvF2= NHK2XZBUSU6JRWK=
NCI-H2126 NHPHXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LxcWlEPTB;MD61OlgyPSEQvF2= NWL5RXdTW0GQR1XS
SNU-C2B MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C2V2lEPTB;MD61O|k4PyEQvF2= MW\TRW5ITVJ?
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MKN1 MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LRWWlEPTB;MD61PFc5OyEQvF2= NFfjUldUSU6JRWK=
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OVCAR-3 NX[3UFdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3XTWM2OD1yLkW5N|QyKM7:TR?= NWPkV|k2W0GQR1XS
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SW872 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK2PXVyUUN3ME2wMlYxPzZ|IN88US=> M4T3VXNCVkeHUh?=
CP66-MEL MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zEW2lEPTB;MD62NFk3QSEQvF2= M1\OTnNCVkeHUh?=
NCI-H661 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu3WoVKSzVyPUCuOlEyODRizszN NYCyVXFLW0GQR1XS
UACC-893 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn5dpNKSzVyPUCuOlM3QDFizszN NHHYcHRUSU6JRWK=
JVM-3 NV\qd4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Twd2lEPTB;MD62N|gxPCEQvF2= M3SzPXNCVkeHUh?=
SF268 NEjJOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3zSJp2UUN3ME2wMlY1OzR7IN88US=> MVfTRW5ITVJ?
OCI-AML2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0TWM2OD1yLk[1N|k4KM7:TR?= MoHZV2FPT0WU
RPMI-8226 NH\KelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W2VGlEPTB;MD62OlMzOyEQvF2= M3fYfHNCVkeHUh?=
MKN28 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNk[2NlQh|ryP MofWV2FPT0WU
MDA-MB-453 M4TuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr0dJhkUUN3ME2wMlY4OThizszN MV\TRW5ITVJ?
BV-173 MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNki2O|kh|ryP NV\l[WlCW0GQR1XS
NCI-H358 NGLDeWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ToNWlEPTB;MD62PFczPiEQvF2= MkTIV2FPT0WU
NCI-H1651 NH;FNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DRTmlEPTB;MD63JO69VQ>? NHXKT4NUSU6JRWK=
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... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
in solvent
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • Answer:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID