Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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9 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NULJdWpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMECwN|A{KM7:TR?= MXnTRW5ITVJ?
IST-MEL1 NUe0NppzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMECwOFA4KM7:TR?= M136UXNCVkeHUh?=
NCI-SNU-1 NXza[oNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHMTWM2OD1yLkCwNlA4KM7:TR?= MmnDV2FPT0WU
FADU NFTINWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUftOGcxUUN3ME2wMlAxOjB7IN88US=> NYjTdWY5W0GQR1XS
C32 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuxdYZ[UUN3ME2wMlAxOzB2IN88US=> MVnTRW5ITVJ?
D-566MG NUG2c3doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH2TWM2OD1yLkCwN|kh|ryP MnXVV2FPT0WU
LXF-289 NYjnc3BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW2cmhKSzVyPUCuNFA1OTlizszN NWn5NZpYW0GQR1XS
HGC-27 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;qTWM2OD1yLkCwOVEh|ryP M3O5UHNCVkeHUh?=
RPMI-7951 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXmfnJKSzVyPUCuNFA4OTdizszN MV7TRW5ITVJ?
HSC-3 NH3ISJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLEXWxrUUN3ME2wMlAxQTJ7IN88US=> M4PLSXNCVkeHUh?=
MIA-PaCa-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnywTWM2OD1yLkCxNFA6KM7:TR?= MknXV2FPT0WU
KS-1 NXTCVoRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W1VWlEPTB;MD6wNVM2PSEQvF2= M3jjNHNCVkeHUh?=
CAL-51 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTlZ|c4UUN3ME2wMlAyPDB3IN88US=> MV\TRW5ITVJ?
MDA-MB-361 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEG0PVUh|ryP MnnxV2FPT0WU
TI-73 MnnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfuOldKSzVyPUCuNFE4QTZizszN NH[0XpVUSU6JRWK=
AGS NVvoNoRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfpXm5KSzVyPUCuNFE6OzhizszN NF7xbY5USU6JRWK=
NCI-H460 NHnsdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEG5O|Qh|ryP MWXTRW5ITVJ?
A204 NGrvXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjwNmNKSzVyPUCuNFIzPDlizszN M1LHXXNCVkeHUh?=
CHL-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPJWHp2UUN3ME2wMlAzOjVzIN88US=> M1jlW3NCVkeHUh?=
DU-4475 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\ENXk4UUN3ME2wMlAzOjZzIN88US=> Mn\lV2FPT0WU
CGTH-W-1 NFzBeGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\rTWM2OD1yLkCyN|Q6KM7:TR?= MorMV2FPT0WU
HCC2218 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O5fGlEPTB;MD6wNlQ6PCEQvF2= NIOx[YVUSU6JRWK=
A2780 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEK1N|Eh|ryP M3;jVXNCVkeHUh?=
NCI-H720 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHmTWM2OD1yLkCyOVQ3KM7:TR?= NVPIR|lMW0GQR1XS
NCI-N87 NU\WTJlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEK1PVMh|ryP MX\TRW5ITVJ?
CHP-212 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnLU3N3UUN3ME2wMlAzPjJ6IN88US=> MXPTRW5ITVJ?
NCI-H23 NGHFRppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEK2OlUh|ryP NVrhcWhTW0GQR1XS
D-263MG MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvsNZlKSzVyPUCuNFI4QDZizszN NWPLSpU3W0GQR1XS
ME-180 M1nOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;lNGlEPTB;MD6wNlg6OSEQvF2= NUXyXJJ6W0GQR1XS
SW982 MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEK5PVkh|ryP MXrTRW5ITVJ?
OE19 NUTC[XhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEOwO|ch|ryP NGDDOZlUSU6JRWK=
SK-LU-1 M1nTXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7zSHpKSzVyPUCuNFMxQDJizszN MUDTRW5ITVJ?
H4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrmXm92UUN3ME2wMlA{ODlizszN M1:0XXNCVkeHUh?=
HT-144 NFT4NZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPyUYN7UUN3ME2wMlA{ODl|IN88US=> M{PHPXNCVkeHUh?=
SK-UT-1 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEOxO|gh|ryP M4XmbHNCVkeHUh?=
D-336MG M2rsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[4T3MzUUN3ME2wMlA{OzB7IN88US=> Mn[wV2FPT0WU
MDA-MB-175-VII MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;JeZRKSzVyPUCuNFM{PTRizszN MUjTRW5ITVJ?
GAMG NHzvU4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnZOmdyUUN3ME2wMlA{PDN3IN88US=> NUfqfJI2W0GQR1XS
CP50-MEL-B NUC5eYFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\qV2lEPTB;MD6wN|Q2KM7:TR?= NXrxW|IxW0GQR1XS
OVCAR-5 NWq5b|ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnG[IFKSzVyPUCuNFM1QCEQvF2= NWLPXXg5W0GQR1XS
SK-MES-1 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHM[I9XUUN3ME2wMlA{PjB4IN88US=> NUnv[JB{W0GQR1XS
VM-CUB-1 NH3uTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7xTWM2OD1yLkCzOlU4KM7:TR?= NWf5dotJW0GQR1XS
WM-115 NX\HRYROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoftTWM2OD1yLkCzO|YzKM7:TR?= MVnTRW5ITVJ?
DSH1 M3TZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjyTWM2OD1yLkCzPFA4KM7:TR?= NVW4Xoo3W0GQR1XS
Becker NUHjZ25yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXyVJlPUUN3ME2wMlA{QDh3IN88US=> MWTTRW5ITVJ?
SW962 M3zZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXtTWM2OD1yLkCzPVQ2KM7:TR?= Mn\VV2FPT0WU
TYK-nu MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\LToFKSzVyPUCuNFM6QDVizszN M3vBfXNCVkeHUh?=
HO-1-N-1 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPIXGxrUUN3ME2wMlA1ODJzIN88US=> NWPTPG1DW0GQR1XS
T98G NHThSVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnHTWM2OD1yLkC0NVA{KM7:TR?= MmDzV2FPT0WU
ACN M1HOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe1VHl[UUN3ME2wMlA1OTZ{IN88US=> NV7aOpM6W0GQR1XS
SW780 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLYTWM2OD1yLkC0NlA{KM7:TR?= NF3YdpZUSU6JRWK=
Detroit562 MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HLbmlEPTB;MD6wOFI{QSEQvF2= NInnVZhUSU6JRWK=
BB49-HNC NVL4fWhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMESyOFMh|ryP MkXoV2FPT0WU
HN M2PpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMESyO|Ih|ryP NVv5SJJTW0GQR1XS
H9 NVK3OnBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r5XWlEPTB;MD6wOFM4OSEQvF2= NYTGW4ZzW0GQR1XS
VA-ES-BJ NFzGT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C2T2lEPTB;MD6wOFQ1PyEQvF2= M4LkV3NCVkeHUh?=
MEL-JUSO MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjrTWM2OD1yLkC0OFc2KM7:TR?= NITDdGNUSU6JRWK=
BT-474 MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLVTWM2OD1yLkC0OUDPxE1? NI\FXmVUSU6JRWK=
CaR-1 NX7hUI95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHOTm1KSzVyPUCuNFQ2PDlizszN M16zOnNCVkeHUh?=
PSN1 M4TX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj5dlZKSzVyPUCuNFQ3ODNizszN MYTTRW5ITVJ?
KYSE-510 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrKcZFFUUN3ME2wMlA1PjR7IN88US=> NUe4VmRoW0GQR1XS
KP-4 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDlTWM2OD1yLkC0O|U{KM7:TR?= MWTTRW5ITVJ?
KYSE-410 NXT1U|E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7UTWM2OD1yLkC0O|czKM7:TR?= MlvLV2FPT0WU
G-402 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHEb21OUUN3ME2wMlA1Pzh7IN88US=> MnjkV2FPT0WU
DOK MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO1coZvUUN3ME2wMlA1QTB{IN88US=> NXrRPYJ5W0GQR1XS
COR-L88 M1W0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm0d2ZKSzVyPUCuNFQ6OTJizszN NU\GRXVwW0GQR1XS
SKG-IIIa NF7xOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMES5PFYh|ryP NEjsVolUSU6JRWK=
AN3-CA MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XaUWlEPTB;MD6wOUDPxE1? M2TBcHNCVkeHUh?=
SW48 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSZnF3UUN3ME2wMlA2ODN7IN88US=> NUXXOFhjW0GQR1XS
YKG-1 M{fzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLaXHZKSzVyPUCuNFUxPzFizszN MnvrV2FPT0WU
KYSE-150 M2TFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIToR|ZKSzVyPUCuNFUzOzVizszN NG\Oe2ZUSU6JRWK=
HuO-3N1 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPwcHNFUUN3ME2wMlA2OjN5IN88US=> Mo\HV2FPT0WU
LB1047-RCC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPGe4RKSzVyPUCuNFUzQTZizszN M2DzO3NCVkeHUh?=
NCI-H2030 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjl[GtKSzVyPUCuNFU1OTRizszN NV22U4EzW0GQR1XS
YH-13 MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vUcmlEPTB;MD6wOVczOiEQvF2= MXfTRW5ITVJ?
5637 NX;US4huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;zW5dZUUN3ME2wMlA2PzRizszN M2PtTXNCVkeHUh?=
LOXIMVI NHjxdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEW4O|Ih|ryP NEe2[WdUSU6JRWK=
GT3TKB MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPZWYtKSzVyPUCuNFU6PDJizszN Mm\rV2FPT0WU
TCCSUP NV3Mb3hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjQfFVKSzVyPUCuNFU6PjRizszN M{P6ZnNCVkeHUh?=
EPLC-272H MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrjSJRUUUN3ME2wMlA3OjB3IN88US=> NE\qe2ZUSU6JRWK=
LU-99A MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvpVGl6UUN3ME2wMlA3OjN5IN88US=> NVTIPYliW0GQR1XS
NCI-H1755 NFHidXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLTTWM2OD1yLkC2N|QyKM7:TR?= M37u[3NCVkeHUh?=
KM12 M3v2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrY[HlqUUN3ME2wMlA3OzR6IN88US=> M{XDcXNCVkeHUh?=
SF295 MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnKPGFtUUN3ME2wMlA3PDV{IN88US=> MlrLV2FPT0WU
MZ2-MEL MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjNTWM2OD1yLkC2OVU{KM7:TR?= Mn\RV2FPT0WU
HEC-1 M{SyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzEXmw3UUN3ME2wMlA3PTh6IN88US=> MWDTRW5ITVJ?
SW684 M1jhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC1TWM2OD1yLkC2OVkyKM7:TR?= NXjmfZNTW0GQR1XS
SF539 NFLPbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fRR2lEPTB;MD6wOlY5OSEQvF2= M13zSXNCVkeHUh?=
GMS-10 NVXBfFE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDaTWM2OD1yLkC2Olk6KM7:TR?= M{nu[nNCVkeHUh?=
MV-4-11 NX7BN5dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vzOmlEPTB;MD6wOlgxOyEQvF2= NWfRVW9zW0GQR1XS
HT-29 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zkcWlEPTB;MD6wOlkyQSEQvF2= NYe3NnZUW0GQR1XS
23132-87 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPhfGxiUUN3ME2wMlA3QTVizszN MknZV2FPT0WU
SW620 M{Doe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfsNphKSzVyPUCuNFcxOjZizszN M3jYdXNCVkeHUh?=
HCC1806 NXi2fYl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7Bc4lKSzVyPUCuNFcyOzFizszN NIqz[|JUSU6JRWK=
Hs-578-T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETzdVZKSzVyPUCuNFczODhizszN M{ntOXNCVkeHUh?=
A2058 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3XU3lKSzVyPUCuNFczOjhizszN M3vEWHNCVkeHUh?=
MEL-HO NGrmVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpTWM2OD1yLkC3NlU2KM7:TR?= NX7ySZVUW0GQR1XS
HCC2998 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzwPWhKSzVyPUCuNFc{PDdizszN M4XCUXNCVkeHUh?=
HuO9 MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrrVYlKSzVyPUCuNFc2QDlizszN NEXRc2xUSU6JRWK=
CAL-39 NI\vPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\SXFhKSzVyPUCuNFc4PjZizszN NILUdFRUSU6JRWK=
M14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4my[mlEPTB;MD6wO|kyOyEQvF2= M1S5OHNCVkeHUh?=
BFTC-909 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\UV2lEPTB;MD6wO|k3QSEQvF2= MUnTRW5ITVJ?
TE-11 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm4e5lCUUN3ME2wMlA4QTl4IN88US=> NHfUbVlUSU6JRWK=
TGBC1TKB NH\FPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXew[|JZUUN3ME2wMlA5ODR|IN88US=> MXvTRW5ITVJ?
L-363 NInS[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\4XllKSzVyPUCuNFgzODZizszN MVXTRW5ITVJ?
A431 NETIToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfVTWM2OD1yLkC4NlEh|ryP MVfTRW5ITVJ?
MKN45 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEiyNVkh|ryP NETDPWdUSU6JRWK=
HT-1080 NYm0dlBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEi0N|kh|ryP NWPjZWpnW0GQR1XS
OVCAR-8 M2LDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\UfWlEPTB;MD6wPFYzOiEQvF2= NGnqVphUSU6JRWK=
LCLC-97TM1 NVe5cpJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnvcHpGUUN3ME2wMlA5PzJ6IN88US=> NHrr[VlUSU6JRWK=
M059J MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWyTWM2OD1yLkC5NFI4KM7:TR?= NYjKcJJrW0GQR1XS
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TE-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH4XVdKSzVyPUCuNFkzODRizszN MWjTRW5ITVJ?
KYSE-180 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz6XIVDUUN3ME2wMlA6OjZ{IN88US=> NFzhS2RUSU6JRWK=
D-247MG NYDTdZNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LvUWlEPTB;MD6wPVQ2PSEQvF2= NYTReG15W0GQR1XS
8-MG-BA MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEm0O|Ih|ryP NUDLSXExW0GQR1XS
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NCI-H2122 NYW4PYZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1eyOGlEPTB;MD6wPVc1PSEQvF2= NVTzb2V4W0GQR1XS
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LB2241-RCC NGPjdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMUCwOVQh|ryP MonQV2FPT0WU
SN12C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnyOYNtUUN3ME2wMlExOTB5IN88US=> M{juVXNCVkeHUh?=
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PANC-03-27 NFLyW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrqcnF3UUN3ME2wMlExOjh4IN88US=> NUWydmI1W0GQR1XS
NCI-H1581 NHPxNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\Xb2lEPTB;MD6xNFI6KM7:TR?= NI\Me3RUSU6JRWK=
U-87-MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PxOmlEPTB;MD6xNFMxPyEQvF2= Ml3KV2FPT0WU
G-401 NG\KbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMUCzOVMh|ryP M{m3VXNCVkeHUh?=
SiHa NHO4cFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPGTWM2OD1yLkGwOFg3KM7:TR?= MoHjV2FPT0WU
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BB65-RCC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqwWWJKSzVyPUCuNVA2PTRizszN NV22Xms1W0GQR1XS
NKM-1 NET5NZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G4W2lEPTB;MD6xNFY3PiEQvF2= NVTOfXlWW0GQR1XS
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COLO-679 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYewN4JPUUN3ME2wMlEyOjFzIN88US=> NWPDTHlvW0GQR1XS
TE-8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrlSZJUUUN3ME2wMlEyOjZ2IN88US=> MUPTRW5ITVJ?
SK-MEL-28 M2HVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGzcVdOUUN3ME2wMlEyOzJzIN88US=> MXXTRW5ITVJ?
SH-4 NXHkUFBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHXmlEPTB;MD6xNVM2PiEQvF2= MmW2V2FPT0WU
KALS-1 NXzWW29HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYToVFEzUUN3ME2wMlEyOzl|IN88US=> Ml7JV2FPT0WU
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OMC-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMUG3PVch|ryP Mnr3V2FPT0WU
BT-549 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHHSG5KSzVyPUCuNVE4QTlizszN Mn;2V2FPT0WU
NCI-H28 NUm2SnpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjpTWM2OD1yLkGxPFE4KM7:TR?= NGCzVJhUSU6JRWK=
RXF393 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XXbGlEPTB;MD6xNVk5OiEQvF2= Mni3V2FPT0WU
COLO-829 NVTu[|BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXGWW9KSzVyPUCuNVIxODVizszN NUPrVHpDW0GQR1XS
HMV-II MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMUKwNkDPxE1? M4e0S3NCVkeHUh?=
SW1990 NY\2XVVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;5dXNKSzVyPUCuNVIyPTdizszN NGC5cYdUSU6JRWK=
NCI-H1437 NWTPZ2s6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMUKxOVch|ryP NV3t[lBuW0GQR1XS
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SAS M1zsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mln1TWM2OD1yLkGyOlkh|ryP MmmwV2FPT0WU
NCI-H1666 NVyzOXdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrSUWFKSzVyPUCuNVI4PzRizszN NFjOVm1USU6JRWK=
A375 M1faN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTMWGQzUUN3ME2wMlEzPzd6IN88US=> MXXTRW5ITVJ?
CAMA-1 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fTXmlEPTB;MD6xNlkzPCEQvF2= NV3oXohPW0GQR1XS
HuP-T4 NHHvepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYftfpdmUUN3ME2wMlEzQTR|IN88US=> MUDTRW5ITVJ?
NCI-H292 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jYTGlEPTB;MD6xN|EyKM7:TR?= MX\TRW5ITVJ?
PC-14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHFOo5KSzVyPUCuNVMzOTFizszN MXrTRW5ITVJ?
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SK-MEL-24 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULSN4d4UUN3ME2wMlE{QDdizszN M{PPRnNCVkeHUh?=
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NCI-H2452 NWez[|FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2naO2lEPTB;MD6xN|k2PiEQvF2= M3:wbnNCVkeHUh?=
RT-112 NVjZNoVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLJ[WpjUUN3ME2wMlE1ODN3IN88US=> MlPJV2FPT0WU
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LC-2-ad MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLxdWhQUUN3ME2wMlE1OTJzIN88US=> NXLsWnJ7W0GQR1XS
MPP-89 NFWzbVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrFTWM2OD1yLkG0NVI2KM7:TR?= NGC2RYxUSU6JRWK=
NUGC-3 NXu2V5pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTtbmxmUUN3ME2wMlE1PDd6IN88US=> MVzTRW5ITVJ?
GI-1 M{j6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPpTmZoUUN3ME2wMlE1PTV6IN88US=> MYDTRW5ITVJ?
HCC1419 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjQSGFjUUN3ME2wMlE1PTd4IN88US=> MUPTRW5ITVJ?
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NCI-H2347 NHm3[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLmTWM2OD1yLkG0PFM6KM7:TR?= M4HsWXNCVkeHUh?=
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NCI-H1648 NUfEVmZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrPbmtKUUN3ME2wMlE2OjN{IN88US=> MmrUV2FPT0WU
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CAL-62 NELtNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDhdpN5UUN3ME2wMlE3OTZ7IN88US=> M2jwZnNCVkeHUh?=
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OC-314 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjmTWM2OD1yLkG2Olkh|ryP MmjLV2FPT0WU
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HT-1376 NHHGdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvGfWpZUUN3ME2wMlE3QTN4IN88US=> M{PEN3NCVkeHUh?=
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BB30-HNC M4rJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\TRYZKSzVyPUCuNVc{OyEQvF2= MXrTRW5ITVJ?
NCI-H2087 M4[2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TJZWlEPTB;MD6xO|M3QCEQvF2= NVT4W5J5W0GQR1XS
NCI-H2170 NHfheFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnLUZZKSzVyPUCuNVc2OzZizszN M{e1SHNCVkeHUh?=
SK-OV-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5TWM2OD1yLkG3OVcyKM7:TR?= MV3TRW5ITVJ?
MZ7-mel NIDMPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rJfmlEPTB;MD6xO|Y1QSEQvF2= NX36[YZxW0GQR1XS
NCI-H650 NIXLcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrMVGZVUUN3ME2wMlE4Pjh{IN88US=> MWTTRW5ITVJ?
KOSC-2 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMUe3N|Qh|ryP MmPtV2FPT0WU
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MDA-MB-157 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\VTWM2OD1yLkG4NFgzKM7:TR?= MXzTRW5ITVJ?
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LK-2 M4DufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DKdGlEPTB;MD6xPFMxOyEQvF2= NFexNJlUSU6JRWK=
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DEL M2Swcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTLU5RKSzVyPUCuNVg1PSEQvF2= M{W2WnNCVkeHUh?=
NCI-H1395 NHr0UmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrmOGl[UUN3ME2wMlE5Pjh{IN88US=> NWDpcIxGW0GQR1XS
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BCPAP MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMUi4O|Ih|ryP MknjV2FPT0WU
CAL-27 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;vTlZHUUN3ME2wMlE6ODJ{IN88US=> MXLTRW5ITVJ?
RD MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMUmxNVMh|ryP M{D6cHNCVkeHUh?=
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COLO-680N MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf3UFlKSzVyPUCuNVk{PjRizszN NV\a[5RwW0GQR1XS
NCI-H1650 M1S4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljmTWM2OD1yLkKwNFU4KM7:TR?= MXzTRW5ITVJ?
SBC-5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe4UHFKSzVyPUCuNlAyOThizszN NH7SVmdUSU6JRWK=
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HPAF-II MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrtOpdzUUN3ME2wMlIyOjZ2IN88US=> M4\5XXNCVkeHUh?=
769-P Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTrZ|hKSzVyPUCuNlEzQCEQvF2= NYHkSXVVW0GQR1XS
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NCI-H2228 MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nxdmlEPTB;MD6zOVM2PyEQvF2= MnPyV2FPT0WU
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NCI-H661 NYjvZ4llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD1yLk[xNVA1KM7:TR?= MYTTRW5ITVJ?
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MDA-MB-453 NXfSb4FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwNkexPEDPxE1? M3j5VnNCVkeHUh?=
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C8166 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTVwM{[zN|kh|ryP NUfHTG17W0GQR1XS
LS-1034 M1XGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n0NGlEPTB;NT60NlMxPyEQvF2= NXL3eVJWW0GQR1XS
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NCI-H1092 NG\NbmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPaT2NjUUN3ME21MlczQDR|IN88US=> NHjB[WdUSU6JRWK=
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ECC10 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3vTWM2OD15LkGwNVAyKM7:TR?= Mo\BV2FPT0WU
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NCI-H1993 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nOUWlEPTB;Nz64N|A3OyEQvF2= NH3UNYdUSU6JRWK=
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KG-1 MkLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTlwNUi0OVYh|ryP NXniOYU{W0GQR1XS
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697 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDHTWM2OD1zMT6xOFczKM7:TR?= MV3TRW5ITVJ?
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NCI-H1770 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT2TWM2OD1zMj6xNlYh|ryP NUDOfFRIW0GQR1XS
SW13 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\ENXBKSzVyPUGyMlE2PDFizszN M3G4bXNCVkeHUh?=
MZ1-PC MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTF{LkW0OVIh|ryP NGDtdJpUSU6JRWK=
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HLE MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTLZnRKSzVyPUGyMlgzOTVizszN Ml3PV2FPT0WU
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COLO-320-HSR NUXpS3p[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv3RlVKSzVyPUGzMlc{QDFizszN NH3jdYJUSU6JRWK=
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MEG-01 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF2LkO3NFgh|ryP MoLTV2FPT0WU
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NCI-H1304 NEK3cnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7WRpV[UUN3ME2xOU4xPDJ3IN88US=> NWjte4pLW0GQR1XS
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NCI-H2342 NICxTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHjTWM2OD1zNT6yNFQ1KM7:TR?= Ml;qV2FPT0WU
LAN-6 NGnRdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXmRmc4UUN3ME2xOU41PDF2IN88US=> NFHOTIVUSU6JRWK=
JVM-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PpWWlEPTB;MUWuOVc1QCEQvF2= MkTqV2FPT0WU
P30-OHK MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fBNWlEPTB;MU[uNFYyPCEQvF2= M1rwW3NCVkeHUh?=
C-33-A NXrTdYF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG3TWM2OD1zNj62NlE1KM7:TR?= M{XGfHNCVkeHUh?=
RPMI-8866 NH:2RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLqRoIxUUN3ME2xOk45PDl4IN88US=> M4S3RnNCVkeHUh?=
NCI-H630 M4PkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrwTWM2OD1zNj64OVM4KM7:TR?= Mof4V2FPT0WU
KYSE-140 M3\VXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK1T5dKSzVyPUG3MlIxOjhizszN M1P6VHNCVkeHUh?=
T84 NFLxVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjP[op4UUN3ME2xPE45Pjl3IN88US=> MnjQV2FPT0WU
KU-19-19 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTw[VZIUUN3ME2xPE46PjB6IN88US=> M4Hlc3NCVkeHUh?=
BALL-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\nTWM2OD1zOT6zN|k6KM7:TR?= M2nYbXNCVkeHUh?=
Calu-6 M4DIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzSV3RKSzVyPUG5MlQ6OiEQvF2= MoXDV2FPT0WU
EGI-1 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXpemtKSzVyPUG5MlU6QCEQvF2= M1;mPXNCVkeHUh?=
MFH-ino NHq1T5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHmWZlKSzVyPUG5Mlc1PTRizszN MkXtV2FPT0WU
GB-1 NF\3WZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJyLkO1N|Uh|ryP M4jve3NCVkeHUh?=
NCI-H1693 M{DmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXJS5hKSzVyPUKwMlY2ODVizszN Mn7zV2FPT0WU
SW1116 M37mVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJyLkmzOlIh|ryP NGG3TppUSU6JRWK=
H-EMC-SS M3P0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLNTWM2OD1{Mj6wOFUh|ryP NFrpenBUSU6JRWK=
D-502MG M4Ttc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\6TWM2OD1{Mj64NlYyKM7:TR?= NHToNYNUSU6JRWK=
IA-LM M4naUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTFUXA2UUN3ME2yN{4zPDl|IN88US=> NUWye2VGW0GQR1XS
SW1463 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHCe|NKSzVyPUKzMlc6KM7:TR?= MVXTRW5ITVJ?
JAR MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\3PFhLUUN3ME2yOE4{Ojl|IN88US=> MX7TRW5ITVJ?
HT MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrISoU1UUN3ME2yOE41PzV|IN88US=> MYjTRW5ITVJ?
LCLC-103H NFTlS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzXSnYxUUN3ME2yOE45PDR7IN88US=> NFfYemhUSU6JRWK=
SNU-449 M3LwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOx[|lLUUN3ME2yOE45PzRzIN88US=> MnzYV2FPT0WU
KE-37 M3XLeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJ3LkC5Nlgh|ryP NVnoTlE4W0GQR1XS
NCI-H1623 M3;6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofxTWM2OD1{Nz6xN|A{KM7:TR?= M2r3TXNCVkeHUh?=
MOLT-13 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ5LkO1NVYh|ryP NX6wWG1uW0GQR1XS
COLO-741 NX7vcI1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXzeWxKSzVyPUOxMlM{OzNizszN NWPlTFRnW0GQR1XS
NB6 M1XmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW3cpVKSzVyPUOyMlI5PzZizszN NHzlZYVUSU6JRWK=
MOLT-16 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfvW3BqUUN3ME2zN{4xODV3IN88US=> Mn3MV2FPT0WU
IST-MES1 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTN2LkC1OFEh|ryP MlvUV2FPT0WU
A4-Fuk MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrvN4diUUN3ME2zOU4xPjZizszN MnvSV2FPT0WU
CAL-85-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonpTWM2OD1|NT6yPFE4KM7:TR?= NVTqbWw5W0GQR1XS
CCRF-CEM MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTN5LkG1N|Yh|ryP MV\TRW5ITVJ?
HAL-01 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj1TWM2OD1|OD60PFg6KM7:TR?= M13EXHNCVkeHUh?=
HEL NEfFZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLETVNpUUN3ME20N{4{PDB7IN88US=> M1Lrc3NCVkeHUh?=
EW-1 M3exSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK5bWNKSzVyPUSzMlQ4PjhizszN M4LHNnNCVkeHUh?=
MDA-MB-231 NFj4fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTR3LkGxPVkh|ryP NUPkOnRlW0GQR1XS
ABC-1 NF3ucJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXrTWM2OD12Nj64OVM5KM7:TR?= NGDI[o9USU6JRWK=
NCI-H446 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fVU2lEPTB;NEiuOVA2QCEQvF2= Mn\rV2FPT0WU
MHH-PREB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR7Lk[wNFch|ryP M2PNS3NCVkeHUh?=
DOHH-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTpZ4hbUUN3ME20PU43PjV4IN88US=> NEDwWZRUSU6JRWK=
GCT MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLGTWM2OD12OT62PVc3KM7:TR?= NILVbpNUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
in solvent
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00773344 Completed Solid Tumors|Breast Cancer Bristol-Myers Squibb December 2005 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • Answer:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID