Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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9 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD2RpFZUUN3ME2wMlAxODNyMzFOwG0> NFGyd2FUSU6JRWK=
IST-MEL1 NILyfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7GRVlvUUN3ME2wMlAxODRyNzFOwG0> MVzTRW5ITVJ?
NCI-SNU-1 MoPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrId4hxUUN3ME2wMlAxOjB5IN88US=> MoDGV2FPT0WU
FADU NHu4W25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zGTGlEPTB;MD6wNFIxQSEQvF2= NF;YV|lUSU6JRWK=
C32 MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK2TWM2OD1yLkCwN|A1KM7:TR?= MkKxV2FPT0WU
D-566MG NYX0eZRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH3TWM2OD1yLkCwN|kh|ryP NV3DSFJ3W0GQR1XS
LXF-289 NWjBVlJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrIZY5KSzVyPUCuNFA1OTlizszN M1zGcHNCVkeHUh?=
HGC-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDTO4VKSzVyPUCuNFA2OSEQvF2= MoOyV2FPT0WU
RPMI-7951 NXnZ[plST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXOZlA2UUN3ME2wMlAxPzF5IN88US=> MX7TRW5ITVJ?
HSC-3 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;xVmlEPTB;MD6wNFkzQSEQvF2= M3fXZ3NCVkeHUh?=
MIA-PaCa-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLJN5JKSzVyPUCuNFExODlizszN NU\DdnN1W0GQR1XS
KS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEGzOVUh|ryP NILUdFVUSU6JRWK=
CAL-51 MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7HTWM2OD1yLkCxOFA2KM7:TR?= MUnTRW5ITVJ?
MDA-MB-361 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEG0PVUh|ryP NXTSN3hEW0GQR1XS
TI-73 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEG3PVYh|ryP MX;TRW5ITVJ?
AGS NVT2e2NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHO4SGRKSzVyPUCuNFE6OzhizszN NIjCSGNUSU6JRWK=
NCI-H460 NILrd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nEO2lEPTB;MD6wNVk4PCEQvF2= NV\nXW9vW0GQR1XS
A204 NH7EXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjXblhKSzVyPUCuNFIzPDlizszN MnHVV2FPT0WU
CHL-1 NID1W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{iydGlEPTB;MD6wNlI2OSEQvF2= MoDIV2FPT0WU
DU-4475 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEKyOlEh|ryP MUPTRW5ITVJ?
CGTH-W-1 NIHqVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDKTWM2OD1yLkCyN|Q6KM7:TR?= M2K4W3NCVkeHUh?=
HCC2218 M2CyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEK0PVQh|ryP M3XROXNCVkeHUh?=
A2780 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIexRmVKSzVyPUCuNFI2OzFizszN MkXpV2FPT0WU
NCI-H720 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\BWWlEPTB;MD6wNlU1PiEQvF2= MofmV2FPT0WU
NCI-N87 M4XCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLbVVXUUN3ME2wMlAzPTl|IN88US=> MWHTRW5ITVJ?
CHP-212 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEK2Nlgh|ryP MmfWV2FPT0WU
NCI-H23 NXHvcY82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCyPYlHUUN3ME2wMlAzPjZ3IN88US=> MYrTRW5ITVJ?
D-263MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrLTWM2OD1yLkCyO|g3KM7:TR?= NWnFNXRoW0GQR1XS
ME-180 M1rhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3iTWM2OD1yLkCyPFkyKM7:TR?= M1nK[nNCVkeHUh?=
SW982 M2rOPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\jeWlEPTB;MD6wNlk6QSEQvF2= MY\TRW5ITVJ?
OE19 NYfFc3Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfORYZKUUN3ME2wMlA{ODd5IN88US=> M{X2UXNCVkeHUh?=
SK-LU-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTs[Zd7UUN3ME2wMlA{ODh{IN88US=> MYXTRW5ITVJ?
H4 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O3VmlEPTB;MD6wN|A6KM7:TR?= MWfTRW5ITVJ?
HT-144 M{HFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEOwPVMh|ryP MmXiV2FPT0WU
SK-UT-1 NV3QTJpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTIT2dKSzVyPUCuNFMyPzhizszN NVnRT3BzW0GQR1XS
D-336MG NIXld3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fuXWlEPTB;MD6wN|MxQSEQvF2= Ml;iV2FPT0WU
MDA-MB-175-VII NEnSPY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEOzOVQh|ryP MUHTRW5ITVJ?
GAMG M4PxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjNO3BIUUN3ME2wMlA{PDN3IN88US=> M{W3R3NCVkeHUh?=
CP50-MEL-B NIXsb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vNTmlEPTB;MD6wN|Q2KM7:TR?= NYfnUXR{W0GQR1XS
OVCAR-5 MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHxUJFKSzVyPUCuNFM1QCEQvF2= MoXnV2FPT0WU
SK-MES-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPoTWM2OD1yLkCzOlA3KM7:TR?= NIXlb5JUSU6JRWK=
VM-CUB-1 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qwfWlEPTB;MD6wN|Y2PyEQvF2= NFzQcJpUSU6JRWK=
WM-115 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrqTG1PUUN3ME2wMlA{PzZ{IN88US=> NVvueld2W0GQR1XS
DSH1 NVLTcnJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2yTm1yUUN3ME2wMlA{QDB5IN88US=> Mn3QV2FPT0WU
Becker MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn4TWM2OD1yLkCzPFg2KM7:TR?= MoLZV2FPT0WU
SW962 NXi1XZdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEO5OFUh|ryP MlfwV2FPT0WU
TYK-nu NVvIW3NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrTRnNKSzVyPUCuNFM6QDVizszN MWrTRW5ITVJ?
HO-1-N-1 NGjUS|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXWXnlKSzVyPUCuNFQxOjFizszN MXjTRW5ITVJ?
T98G NFLyZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW5bVlwUUN3ME2wMlA1OTB|IN88US=> Ml;vV2FPT0WU
ACN NHHxO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DoZ2lEPTB;MD6wOFE3OiEQvF2= NVi5[mV[W0GQR1XS
SW780 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUniRZo5UUN3ME2wMlA1OjB|IN88US=> NFfz[ldUSU6JRWK=
Detroit562 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrjOoxKSzVyPUCuNFQzOzlizszN MXPTRW5ITVJ?
BB49-HNC NFTaN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3iTWM2OD1yLkC0NlQ{KM7:TR?= MX;TRW5ITVJ?
HN M2TWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\RNGlEPTB;MD6wOFI4OiEQvF2= M2n5b3NCVkeHUh?=
H9 MlHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr6VVFKSzVyPUCuNFQ{PzFizszN MVrTRW5ITVJ?
VA-ES-BJ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jN[WlEPTB;MD6wOFQ1PyEQvF2= NV7s[29jW0GQR1XS
MEL-JUSO MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMES0O|Uh|ryP MXjTRW5ITVJ?
BT-474 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrlZVZ5UUN3ME2wMlA1PSEQvF2= NXv1fZlwW0GQR1XS
CaR-1 NXzuO4lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDwU4c4UUN3ME2wMlA1PTR7IN88US=> NHrYVmFUSU6JRWK=
PSN1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrtSmdKSzVyPUCuNFQ3ODNizszN M1rUfHNCVkeHUh?=
KYSE-510 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3lTWM2OD1yLkC0OlQ6KM7:TR?= MYHTRW5ITVJ?
KP-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonQTWM2OD1yLkC0O|U{KM7:TR?= MWrTRW5ITVJ?
KYSE-410 NF\6ZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD5TWM2OD1yLkC0O|czKM7:TR?= M4rVcnNCVkeHUh?=
G-402 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjFbnI2UUN3ME2wMlA1Pzh7IN88US=> NF6zOVZUSU6JRWK=
DOK NXPreHp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzzcIN3UUN3ME2wMlA1QTB{IN88US=> NHXwXW9USU6JRWK=
COR-L88 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH4eVFKSzVyPUCuNFQ6OTJizszN NETGcYhUSU6JRWK=
SKG-IIIa MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HpNmlEPTB;MD6wOFk5PiEQvF2= Ml3CV2FPT0WU
AN3-CA NI\X[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPyTWM2OD1yLkC1JO69VQ>? NFy4TFNUSU6JRWK=
SW48 NIHad5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfofIVKSzVyPUCuNFUxOzlizszN MV3TRW5ITVJ?
YKG-1 NHrUW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33nWWlEPTB;MD6wOVA4OSEQvF2= Mmj3V2FPT0WU
KYSE-150 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTm[ZFKSzVyPUCuNFUzOzVizszN NGO4W3lUSU6JRWK=
HuO-3N1 M2DwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmzcHdKSzVyPUCuNFUzOzdizszN Mn:wV2FPT0WU
LB1047-RCC NYnDfJN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;1dIFKSzVyPUCuNFUzQTZizszN MYnTRW5ITVJ?
NCI-H2030 NXPocHB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[zTGlEPTB;MD6wOVQyPCEQvF2= NYnvUpR1W0GQR1XS
YH-13 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonjTWM2OD1yLkC1O|IzKM7:TR?= NYO4fWJ1W0GQR1XS
5637 NVu0WFd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P6[WlEPTB;MD6wOVc1KM7:TR?= M1LGZnNCVkeHUh?=
LOXIMVI NYfhfFV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrlNI1yUUN3ME2wMlA2QDd{IN88US=> NFzrR3ZUSU6JRWK=
GT3TKB Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi4ZXYyUUN3ME2wMlA2QTR{IN88US=> NF7I[|RUSU6JRWK=
TCCSUP M2niTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\iTWM2OD1yLkC1PVY1KM7:TR?= NXeyeG45W0GQR1XS
EPLC-272H M2fkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z3V2lEPTB;MD6wOlIxPSEQvF2= Mn7CV2FPT0WU
LU-99A MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq2TWM2OD1yLkC2NlM4KM7:TR?= NHLrPWFUSU6JRWK=
NCI-H1755 M{LGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7oTWM2OD1yLkC2N|QyKM7:TR?= MWjTRW5ITVJ?
KM12 NIPpfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzYZXh6UUN3ME2wMlA3OzR6IN88US=> MoO3V2FPT0WU
SF295 NEW2ZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3uSIJKSzVyPUCuNFY1PTJizszN M3vFR3NCVkeHUh?=
MZ2-MEL MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\xbYtKSzVyPUCuNFY2PTNizszN MUTTRW5ITVJ?
HEC-1 NH7kVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37JRmlEPTB;MD6wOlU5QCEQvF2= NWLoNFhJW0GQR1XS
SW684 NX\NR294T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDGTWM2OD1yLkC2OVkyKM7:TR?= MnLPV2FPT0WU
SF539 NIHXbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzzcGlKSzVyPUCuNFY3QDFizszN Mnq2V2FPT0WU
GMS-10 M{P4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwME[2PVkh|ryP MXXTRW5ITVJ?
MV-4-11 NGW0O4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDRWlEPTB;MD6wOlgxOyEQvF2= NFr0cXFUSU6JRWK=
HT-29 NUjheI15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwME[5NVkh|ryP MX7TRW5ITVJ?
23132-87 NE[0[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvtXXRKSzVyPUCuNFY6PSEQvF2= MWTTRW5ITVJ?
SW620 NYn3Z3BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\UVmlEPTB;MD6wO|AzPiEQvF2= Mkm1V2FPT0WU
HCC1806 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LvdWlEPTB;MD6wO|E{OSEQvF2= Mlm1V2FPT0WU
Hs-578-T M2\v[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7OTWM2OD1yLkC3NlA5KM7:TR?= NFe2emZUSU6JRWK=
A2058 MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDDTWM2OD1yLkC3NlI5KM7:TR?= NGXLVFZUSU6JRWK=
MEL-HO NV3iTlNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfkTWM2OD1yLkC3NlU2KM7:TR?= M{iwWHNCVkeHUh?=
HCC2998 NIrlemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXGUItRUUN3ME2wMlA4OzR5IN88US=> MYjTRW5ITVJ?
HuO9 NVKzfFFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrRTmVKSzVyPUCuNFc2QDlizszN Mmj0V2FPT0WU
CAL-39 M2rGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S5XGlEPTB;MD6wO|c3PiEQvF2= NWrCNIFlW0GQR1XS
M14 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17wfWlEPTB;MD6wO|kyOyEQvF2= NYPadnhoW0GQR1XS
BFTC-909 NW\LVIRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O0eWlEPTB;MD6wO|k3QSEQvF2= MWjTRW5ITVJ?
TE-11 NGTaU4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXGTWM2OD1yLkC3PVk3KM7:TR?= NVLMdpJRW0GQR1XS
TGBC1TKB MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1raVmlEPTB;MD6wPFA1OyEQvF2= M3q1fnNCVkeHUh?=
L-363 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLlRVJKSzVyPUCuNFgzODZizszN M3O2OnNCVkeHUh?=
A431 M{Tmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnDXGpuUUN3ME2wMlA5OjFizszN M2Pme3NCVkeHUh?=
MKN45 MorHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEiyNVkh|ryP NFTSRm1USU6JRWK=
HT-1080 NUnJcI9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzZTWM2OD1yLkC4OFM6KM7:TR?= MVjTRW5ITVJ?
OVCAR-8 NU\JdpI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvMcGtWUUN3ME2wMlA5PjJ{IN88US=> NXTCcFNMW0GQR1XS
LCLC-97TM1 NEHFS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nsbGlEPTB;MD6wPFczQCEQvF2= M1PWOXNCVkeHUh?=
M059J MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;QTWM2OD1yLkC5NFI4KM7:TR?= MYLTRW5ITVJ?
SK-MEL-2 NEL6SGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEmwOkDPxE1? NFXPWJNUSU6JRWK=
TE-1 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvKZY43UUN3ME2wMlA6OjB2IN88US=> M4rOVXNCVkeHUh?=
KYSE-180 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEmyOlIh|ryP NEXO[2FUSU6JRWK=
D-247MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XYc2lEPTB;MD6wPVQ2PSEQvF2= MkTnV2FPT0WU
8-MG-BA NU\1WoVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\3TWM2OD1yLkC5OFczKM7:TR?= NUGyXnpoW0GQR1XS
NCI-H1792 M2nkcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fKZWlEPTB;MD6wPVYyQCEQvF2= NITqcplUSU6JRWK=
MCF7 M2DUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEm2O|ch|ryP MUnTRW5ITVJ?
NCI-H2122 NYOyZlNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3eWlEPTB;MD6wPVc1PSEQvF2= M1PSVHNCVkeHUh?=
EFO-27 NYCwZpBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPpbY1lUUN3ME2wMlA6QTl5IN88US=> MWDTRW5ITVJ?
LB2241-RCC Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjzfVUyUUN3ME2wMlExODV2IN88US=> MVHTRW5ITVJ?
SN12C NVqwUWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nMSmlEPTB;MD6xNFExPyEQvF2= M3HwN3NCVkeHUh?=
A498 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC0WolwUUN3ME2wMlExOThizszN MVPTRW5ITVJ?
PANC-03-27 NWPCW5I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMUCyPFYh|ryP NYfmdpMyW0GQR1XS
NCI-H1581 NH;WW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILHc5FKSzVyPUCuNVAzQSEQvF2= MWXTRW5ITVJ?
U-87-MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMUCzNFch|ryP M2\QVHNCVkeHUh?=
G-401 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TwfmlEPTB;MD6xNFM2OyEQvF2= M2HaTnNCVkeHUh?=
SiHa NW\1cFAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[wTWM2OD1yLkGwOFg3KM7:TR?= MVzTRW5ITVJ?
U251 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLqU5Z1UUN3ME2wMlExPTJ3IN88US=> NHH0d|hUSU6JRWK=
MMAC-SF NUjTNXhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUC1N|Eh|ryP MkPVV2FPT0WU
BB65-RCC NV3sc3NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmniTWM2OD1yLkGwOVU1KM7:TR?= MXjTRW5ITVJ?
NKM-1 NYOxWVBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6zTWM2OD1yLkGwOlY3KM7:TR?= NU[yZXRGW0GQR1XS
HD-MY-Z MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrNclVKSzVyPUCuNVA5PzNizszN NE\LZllUSU6JRWK=
TGBC11TKB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnL[mxKSzVyPUCuNVA6ODNizszN M{\4[HNCVkeHUh?=
COLO-679 NGXw[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnMcZRKSzVyPUCuNVEzOTFizszN MYjTRW5ITVJ?
TE-8 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXywT286UUN3ME2wMlEyOjZ2IN88US=> MVPTRW5ITVJ?
SK-MEL-28 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;qUFFKSzVyPUCuNVE{OjFizszN MV3TRW5ITVJ?
SH-4 NELjV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3HTWM2OD1yLkGxN|U3KM7:TR?= NY\1WHB{W0GQR1XS
KALS-1 M1jRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy3bGgyUUN3ME2wMlEyOzl|IN88US=> NVHQTHVwW0GQR1XS
RKO NIi0VFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rHbWlEPTB;MD6xNVc3PCEQvF2= M3zpUHNCVkeHUh?=
OMC-1 NFnYUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nQPGlEPTB;MD6xNVc6PyEQvF2= M3:zVnNCVkeHUh?=
BT-549 NXjISZE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMUG3PVkh|ryP Mn\HV2FPT0WU
NCI-H28 NWjUUoxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMUG4NVch|ryP Ml[wV2FPT0WU
RXF393 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTXZ2czUUN3ME2wMlEyQTh{IN88US=> NVvFVY57W0GQR1XS
COLO-829 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDmTWM2OD1yLkGyNFA2KM7:TR?= NGT3d2ZUSU6JRWK=
HMV-II M4XpTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi5[Gh1UUN3ME2wMlEzODJizszN MYnTRW5ITVJ?
SW1990 NYP4e3hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCdHdmUUN3ME2wMlEzOTV5IN88US=> NH\Hd|lUSU6JRWK=
NCI-H1437 NUD4N|RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT0TWM2OD1yLkGyNVU4KM7:TR?= MVzTRW5ITVJ?
SNB75 M{TnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnaNYZxUUN3ME2wMlEzOTZ7IN88US=> MVfTRW5ITVJ?
EW-3 NY\OTXhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfEe25KSzVyPUCuNVI3PjFizszN NEHEc5lUSU6JRWK=
SAS NHnPTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;5PIFKSzVyPUCuNVI3QSEQvF2= MljiV2FPT0WU
NCI-H1666 NVu2SHVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvuTYRKSzVyPUCuNVI4PzRizszN NH7Ge4ZUSU6JRWK=
A375 M4fkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofwTWM2OD1yLkGyO|c5KM7:TR?= NU[0[3c{W0GQR1XS
CAMA-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLRRXhKSzVyPUCuNVI6OjRizszN MYLTRW5ITVJ?
HuP-T4 M3f6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\ub2pVUUN3ME2wMlEzQTR|IN88US=> M2f0PXNCVkeHUh?=
NCI-H292 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1yLkGzNVEh|ryP M3;hU3NCVkeHUh?=
PC-14 NYX3VGtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPhTWM2OD1yLkGzNlEyKM7:TR?= MXzTRW5ITVJ?
BPH-1 NG\LRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXOXFZKSzVyPUCuNVM1OSEQvF2= MUnTRW5ITVJ?
GAK MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGiye3dKSzVyPUCuNVM2PjdizszN M3jE[HNCVkeHUh?=
VMRC-RCZ M3nkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrrTWM2OD1yLkGzO|YzKM7:TR?= M4DsO3NCVkeHUh?=
SK-MEL-24 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm5eGpKSzVyPUCuNVM5PyEQvF2= M4\XUXNCVkeHUh?=
LB831-BLC NIfhRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMUO4PFMh|ryP NI\aPIpUSU6JRWK=
NCI-H2452 NUPZS3V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvu[nJWUUN3ME2wMlE{QTV4IN88US=> Mk\oV2FPT0WU
RT-112 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjsUWtKSzVyPUCuNVQxOzVizszN NWPlUZI6W0GQR1XS
GP5d M4CwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHCdZNKSzVyPUCuNVQyODRizszN MWHTRW5ITVJ?
LC-2-ad NYGydVJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i3dWlEPTB;MD6xOFEzOSEQvF2= M1:wT3NCVkeHUh?=
MPP-89 M{j6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojuTWM2OD1yLkG0NVI2KM7:TR?= M2jmVnNCVkeHUh?=
NUGC-3 M1zOUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS3TWM2OD1yLkG0OFc5KM7:TR?= Ml\lV2FPT0WU
GI-1 M4fzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7wTWM2OD1yLkG0OVU5KM7:TR?= NVHDb|ZZW0GQR1XS
HCC1419 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj3eW9ZUUN3ME2wMlE1PTd4IN88US=> Mm\hV2FPT0WU
SW1573 NEm5OZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zzR2lEPTB;MD6xOFc2QCEQvF2= MXfTRW5ITVJ?
NCI-H2347 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XPTGlEPTB;MD6xOFg{QSEQvF2= MV3TRW5ITVJ?
Mewo MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3vTWM2OD1yLkG0PFg6KM7:TR?= MlTJV2FPT0WU
639-V MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPVW2wzUUN3ME2wMlE2ODF|IN88US=> MkHnV2FPT0WU
AsPC-1 M{PVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMUWyNlUh|ryP MmnRV2FPT0WU
NCI-H1648 M{jYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXvV5BVUUN3ME2wMlE2OjN{IN88US=> Mkn2V2FPT0WU
786-0 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnmZ5FOUUN3ME2wMlE2OzhzIN88US=> NX7VVVkyW0GQR1XS
ETK-1 M3;vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnhSZh4UUN3ME2wMlE2QSEQvF2= MUfTRW5ITVJ?
BxPC-3 NUP6elg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPnTWM2OD1yLkG1PVY3KM7:TR?= MlftV2FPT0WU
CAL-62 NFvNTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPuU3dKSzVyPUCuNVYyPjlizszN MkTJV2FPT0WU
HCC1937 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPTXoZKSzVyPUCuNVYzPzVizszN MoK3V2FPT0WU
NCI-H1299 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPFOJdKSzVyPUCuNVYzQDVizszN M2LQbHNCVkeHUh?=
SW1088 M1vGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG1fnJRUUN3ME2wMlE3PDF|IN88US=> MXfTRW5ITVJ?
FTC-133 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMU[1OEDPxE1? MWrTRW5ITVJ?
OC-314 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMU[2PUDPxE1? NHHFSmZUSU6JRWK=
SCC-9 NXjoSpg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\3TWM2OD1yLkG2O|E3KM7:TR?= M2iyPXNCVkeHUh?=
HT-1376 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[4VWNKSzVyPUCuNVY6OzZizszN NXjLZWVzW0GQR1XS
U-2-OS M3j5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7CTWM2OD1yLkG3NVc{KM7:TR?= MVzTRW5ITVJ?
COLO-824 NV\wTZVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfNTWM2OD1yLkG3Nlk1KM7:TR?= MoHwV2FPT0WU
BB30-HNC NGjxNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMUezN{DPxE1? MV\TRW5ITVJ?
NCI-H2087 NWPUUJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u3N2lEPTB;MD6xO|M3QCEQvF2= MnHUV2FPT0WU
NCI-H2170 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPOTWM2OD1yLkG3OVM3KM7:TR?= NHrZ[IVUSU6JRWK=
SK-OV-3 NX70[YhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjaXIhKSzVyPUCuNVc2PzFizszN M2T2WHNCVkeHUh?=
MZ7-mel NWW3VIk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPiTIdKSzVyPUCuNVc3PDlizszN NFTENY1USU6JRWK=
NCI-H650 M2nab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTlbJVKSzVyPUCuNVc3QDJizszN MVnTRW5ITVJ?
KOSC-2 M{C3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMUe3N|Qh|ryP MWHTRW5ITVJ?
SCC-4 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW3[HRTUUN3ME2wMlE4Pzd5IN88US=> MYTTRW5ITVJ?
MDA-MB-157 NWPnSHdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq0dIZKSzVyPUCuNVgxQDJizszN MlHmV2FPT0WU
KYSE-520 NFvuW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzkOYJkUUN3ME2wMlE5OiEQvF2= M2\KOnNCVkeHUh?=
LK-2 MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rjR2lEPTB;MD6xPFMxOyEQvF2= M3r6VXNCVkeHUh?=
KNS-81-FD NHv1d2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LXfmlEPTB;MD6xPFM6PCEQvF2= M1;LVXNCVkeHUh?=
IGROV-1 NUPEcIk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPwTWM2OD1yLkG4OFQ{KM7:TR?= NIj2PHBUSU6JRWK=
DEL NGG5S5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\NSHFKSzVyPUCuNVg1PSEQvF2= MUfTRW5ITVJ?
NCI-H1395 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi5NplZUUN3ME2wMlE5Pjh{IN88US=> NXryfnNvW0GQR1XS
JEG-3 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMUi3NFUh|ryP NF7xcVFUSU6JRWK=
BCPAP MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMUi4O|Ih|ryP M3\VZ3NCVkeHUh?=
CAL-27 NHPkPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILLOpZKSzVyPUCuNVkxOjJizszN MV\TRW5ITVJ?
RD NGHl[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vXbGlEPTB;MD6xPVEyOyEQvF2= MlL6V2FPT0WU
RVH-421 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPPNHlKSzVyPUCuNVkyOTZizszN M3nCOHNCVkeHUh?=
Capan-2 MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT1UnRKSzVyPUCuNVkzPTZizszN M4ft[XNCVkeHUh?=
COLO-680N M2XGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMUmzOlQh|ryP NXe4bZNrW0GQR1XS
NCI-H1650 NEDVT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HVVmlEPTB;MD6yNFA2PyEQvF2= NWPzT3lYW0GQR1XS
SBC-5 NHfKO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PpfGlEPTB;MD6yNFEyQCEQvF2= NGTLU4lUSU6JRWK=
U031 NU\SOnZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzRS4ZKSzVyPUCuNlA2PDdizszN MXHTRW5ITVJ?
S-117 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HEUWlEPTB;MD6yNFU3PCEQvF2= MW\TRW5ITVJ?
DoTc2-4510 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TvfWlEPTB;MD6yNFc3QSEQvF2= MkfKV2FPT0WU
AM-38 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nzbWlEPTB;MD6yNFg1QCEQvF2= NIPrTmZUSU6JRWK=
A172 NYf3c|RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPueoJZUUN3ME2wMlIyODJ{IN88US=> Mnv1V2FPT0WU
HPAF-II NWTFWGpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[2PFBKSzVyPUCuNlEzPjRizszN NWPud21HW0GQR1XS
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NCI-H2342 NGnhWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHmTWM2OD1zNT6yNFQ1KM7:TR?= MUjTRW5ITVJ?
LAN-6 NX7YUYpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCxTWM2OD1zNT60OFE1KM7:TR?= MlXqV2FPT0WU
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C-33-A NFHy[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LjXWlEPTB;MU[uOlIyPCEQvF2= M3GzSXNCVkeHUh?=
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Calu-6 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF7LkS5NkDPxE1? MXvTRW5ITVJ?
EGI-1 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTrTWM2OD1zOT61PVgh|ryP MonOV2FPT0WU
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NCI-H1693 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3BTWM2OD1{MD62OVA2KM7:TR?= MXvTRW5ITVJ?
SW1116 NX\1N2EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX6TWM2OD1{MD65N|YzKM7:TR?= M{DZ[XNCVkeHUh?=
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D-502MG M{D6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli2TWM2OD1{Mj64NlYyKM7:TR?= MkG4V2FPT0WU
IA-LM NVTIcWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITxUFJKSzVyPUKzMlI1QTNizszN NXLue5lYW0GQR1XS
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JAR Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m1RmlEPTB;MkSuN|I6OyEQvF2= NXjuO|dOW0GQR1XS
HT M1zW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jwNmlEPTB;MkSuOFc2OyEQvF2= NI\STWVUSU6JRWK=
LCLC-103H NYnBSmpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfsTWM2OD1{ND64OFQ6KM7:TR?= M1vEW3NCVkeHUh?=
SNU-449 MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjC[4NKSzVyPUK0Mlg4PDFizszN M1v5WnNCVkeHUh?=
KE-37 NHvJTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPpTWM2OD1{NT6wPVI5KM7:TR?= M2X3VHNCVkeHUh?=
NCI-H1623 NU[1c3JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zT[2lEPTB;MkeuNVMxOyEQvF2= Mmr3V2FPT0WU
MOLT-13 NV3YXYxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLx[VBKSzVyPUK3MlM2OTZizszN M4npVHNCVkeHUh?=
COLO-741 NGrPS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrqW4Q4UUN3ME2zNU4{OzN|IN88US=> M{XuPXNCVkeHUh?=
NB6 NW\ud|VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofRTWM2OD1|Mj6yPFc3KM7:TR?= MU\TRW5ITVJ?
MOLT-16 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D5XGlEPTB;M{OuNFA2PSEQvF2= NHnu[G9USU6JRWK=
IST-MES1 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jNPWlEPTB;M{SuNFU1OSEQvF2= NED0bYxUSU6JRWK=
A4-Fuk MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H4fWlEPTB;M{WuNFY3KM7:TR?= NYXp[HFxW0GQR1XS
CAL-85-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f0[WlEPTB;M{WuNlgyPyEQvF2= NWT6b295W0GQR1XS
CCRF-CEM NVG0R25DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Xc4I1UUN3ME2zO{4yPTN4IN88US=> NHy0RlRUSU6JRWK=
HAL-01 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvNTWM2OD1|OD60PFg6KM7:TR?= MnXHV2FPT0WU
HEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTR|LkO0NFkh|ryP NWSzeXN1W0GQR1XS
EW-1 M{\Femdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLI[mxjUUN3ME20N{41PzZ6IN88US=> NIH2XoxUSU6JRWK=
MDA-MB-231 NY\WZ4ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S1NGlEPTB;NEWuNVE6QSEQvF2= NEfMcYlUSU6JRWK=
ABC-1 NUTFVZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jvU2lEPTB;NE[uPFU{QCEQvF2= NVHjb205W0GQR1XS
NCI-H446 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK1eFlHUUN3ME20PE42ODV6IN88US=> MWLTRW5ITVJ?
MHH-PREB-1 NI\rTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrsTWM2OD12OT62NFA4KM7:TR?= M1:4WXNCVkeHUh?=
DOHH-2 NWDXbYR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR7Lk[2OVYh|ryP MmnTV2FPT0WU
GCT MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjxd45KSzVyPUS5MlY6PzZizszN MofaV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
in solvent
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00773344 Completed Solid Tumors|Breast Cancer Bristol-Myers Squibb December 2005 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • Answer:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID