Home Cytoskeletal Signaling Microtubule Associated inhibitor - Apoptosis related activator Indibulin For research use only.

Indibulin

Synonyms: ZIO 301, D 24851, Zybulin

Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.

Indibulin Chemical Structure

Indibulin Chemical Structure

CAS: 204205-90-3

Selleck's Indibulin has been cited by 1 publication

Purity & Quality Control

Batch: S044401 DMSO] 40 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

Indibulin Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

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Biological Activity

Description Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.
Targets
Tubulin [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01113970 Unknown status
Metastatic Breast Cancer
Alaunos Therapeutics|Memorial Sloan Kettering Cancer Center
 March 2010 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 389.83 Formula

C22H16ClN3O2
CAS No. 204205-90-3 SDF --
Smiles C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C(=O)NC4=CC=NC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 40 mg/mL ( (102.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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