Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017, 8:199. Honokiol purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells NH23R5ZEgXSxdH;4bYNqfHliYYPzZZk> MnnvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESy17MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF02NjFizszN NYPRSGhWOjJ3M{O5PFM>
Vero E6 cells NUXrR2N5TnWwY4Tpc44h[XO|YYm= NYrtXYtPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhW0GUUzDjc5JwdmG4aYL1d{BqdiCYZYLvJGU3KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZpkhTUyLU1GsJGVEPTB;Nj61JO69VQ>? NHXxeoQyPzZ4M{WzPS=>
human UACC-903 cells M2m0U2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmT2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESy17MEOgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF04NjR3IN88US=> MU[yNlU{Ozl6Mx?=
human A549 cells MVfDfZRwfG:6aXPpeJkh[XO|YYm= NInTPY9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9O{44PSEQvF2= NUD4[XU3OjJ3M{O5PFM>
human CEM cells MnnxR5l1d3SxeHnjbZR6KGG|c3H5 MmrDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzMEBKSzVyPUGwMlkh|ryP M2Dtd|E4PTh5NUey
HEK293 cells NYfQPJlRTnWwY4Tpc44h[XO|YYm= MonwRYdwdmm|dDDhZ5Rqfmm2eTDheEBTYFKjbIDoZUBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgOFghcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0yOS56IN88US=> M1W5R|IxPjl3NEey
human A549 cell NXjkOWFCS3m2b4TvfIlkcXS7IHHzd4F6 M{XQUlI1KGh? NYfL[VYzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVEzNjVzIN88US=> NWX4bIRPOjJ3M{O5PFM>
human HT-29 cells NES1Z49EgXSxdH;4bYNqfHliYYPzZZk> Mof4O|IhcA>? NVTiWW1DS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yOy5{NDFOwG0> M37tb|IzPTN|OUiz
human PBM cells NGPLOlREgXSxdH;4bYNqfHliYYPzZZk> NHXpXGhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSk1iY3XscJMtKEmFNUC9NVYvOSEQvF2= MYSxO|U5PzV5Mh?=
Hep-G2 cells NF7ZcYxEgXSxdH;4bYNqfHliYYPzZZk> NUi5VpZIS3m2b4TvfIlkcXS7IH;mJINwdXCxdX7kJIFo[Wmwc4SgbJVu[W5ibHn2[ZIhfHWvb4KgZ4VtdCCuaX7lJEhJ\XBvR{KpJJdieyCmZYTldo1qdmWmLDDJR|UxRTF4LkWg{txO MmrSNVU2QDJ2M{K=
human HepG2 cells NUjEOG5IWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mnz2NlQhcA>? M1nVR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zNj61JO69VQ>? NFTvWYkzOTh3M{m5NS=>
human K562 cells M{\VRnBzd2yrZnXyZZRqd25iYYPzZZk> M4\1bWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9NlEvOSEQvF2= MnPNNVk2QDl4N{i=
Vero cells NW[zcnJ[S3m2b4TvfIlkcXS7IHHzd4F6 M3;mXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[ncn:gZ4VtdHNuIFnDOVA:OjJwNTFOwG0> Mn7zNVY4OjJ4NkS=
human A2780 cells NXzHTnQ3WHKxbHnm[ZJifGmxbjDhd5NigQ>? M{nXSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ4l{eGyjdHnuMZNmdnOrdHn2[UBpfW2jbjDBNlc5OCClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwNTFOwG0> NF7X[YUyQTV6OU[3PC=>
human SPC-A1 cells NVPpend2WHKxbHnm[ZJifGmxbjDhd5NigQ>? M1TqOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2DDMWEyKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{Pi5zIN88US=> NWLkXW1QOTl3OEm2O|g>
HUVEC cells M2jiOGZ2dmO2aX;uJIF{e2G7 NFTwdZkzOCEQvF2= M3vqNFI1KGh? M4LzS2FvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCqdX3hckBJXV[HQzDj[YxteyCjdDCyNEB2VSCjZoTldkAzPCCqcoOgZpkhf2:3bnStbIVidGmwZzDhd5NigQ>? MU[yNVg2Ozl7MR?=
HEK293 cells M4jJRmZ2dmO2aX;uJIF{e2G7 MYmyOE01QCCq M2nPWWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVnhTNWGucHjhJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZ49mgHC{ZYPzbY5oKHerdHigdGNOYC2kZYThMYdidCCjZoTldkAzPCC2bzC0PEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 MnvONlQ6PTl7OEe=
human SH-SY5Y cells MV;GeY5kfGmxbjDhd5NigQ>? MljGNVAh|ryP NXXGcmJXOzBibXnudy=> NFjOUVhP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hcHWvYX6gV2guW1l3WTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEOKUDDhcoQhXEKKUD3pcoR2[2WmIHPlcIwh\GWjdHigZZQhOTBidV2gbY5kfWKjdHXkJIZweiB|MDDtbY5{KHC{aX;yJJRwKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkA{KGi{czDifUBOXFRiYYPzZZk> M1H5bFIzOTR{NUO5

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Akt Signaling Pathway Map

Related Akt Products0

Tags: buy Honokiol | Honokiol supplier | purchase Honokiol | Honokiol cost | Honokiol manufacturer | order Honokiol | Honokiol distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID