Mocetinostat (MGCD0103)

Catalog No.S1122 Synonyms: MG0103

Mocetinostat (MGCD0103) Chemical Structure

Molecular Weight(MW): 396.44

Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2.

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Cited by 55 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2.
Targets
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
HDAC11 [1]
(Cell-free assay)
HDAC3 [1]
(Cell-free assay)
0.15 μM 0.29 μM 0.59 μM 1.66 μM
In vitro

MGCD0103 inhibits only a subset of the nine human recombinant HDACs, including HDAC1, HDAC2, HDAC3, and HDAC11 at nanomolar or low micromolar concentrations, in a dose-dependent manner. MGCD0103 reveals most potent inhibitory activity against human HDAC1 and HDAC2 enzymes in vitro, and it does not inhibit class II HDACs. The exocyclic amino group in MGCD0103 is necessary for enzyme inhibitory activity because HDAC-inhibitory activity against HDAC1 and HDAC2 is completely abolished with the desamino analogue. The inhibitory activity of MGCD0103 reaches the maximum plateau at 6 μM, and the maximal inhibitable enzyme pool affected by MGCD0103 is 75% of the total enzyme activity in HCT116 cells whereas NVP-LAQ824 inhibits almost 100% of that in these cells. In A549 cells, MGCD0103 also exhibits dose-dependent inhibition of HDAC activity in whole cells. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 NIC1PIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\wVHM1QCCq NX31W2RsUUN3ME2zMlA1KM7:TR?= M3jhOVI3Ozd6MEO4
BT549 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LVTVQ5KGh? M{\Uc2lEPTB;ND6zPEDPxE1? NFLkVXUzPjN5OECzPC=>
MCF7 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe1OFghcA>? M4PrNWlEPTB;MD62O{DPxE1? M3rGTVI3Ozd6MEO4
T47D M4OxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK0PEBp M2rv[2lEPTB;MT6xO{DPxE1? MVKyOlM4QDB|OB?=
MOLP8 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV20PEBp MWLJR|UxRTBwNtMxJFAvODUQvF2= NHz4V2IzPjB7MUWxPC=>
Panc1 MnLlSpVv[3Srb36gRZN{[Xl? MVywMlUwOS9{LkWg{txO MlrKOFghcA>? NEOwSpJFVVOR NYjxRYVYfXC{ZXf1cIF1\XNibXnSMVIxOw>? NI\TcIkzPTh5Mkm0NS=>
Panc1 MVTGeY5kfGmxbjDBd5NigQ>? NGn3cZAxNjVxMT:yMlUh|ryP NEj6WIE1QCCq NVrwbZFsTE2VTx?= MV3y[YR2[2W|IHX4dJJme3Orb36gc4YhYkWEMTDvckBjd3SqIH3SUmEh[W6mIIDyc5RmcW5ibHX2[YzDqA>? MkDiNlU5PzJ7NEG=
Panc1 M3fuW2Fxd3C2b4Ppd{BCe3OjeR?= MV6xxsDPxE1? M1rnXVczyqCq M1LH[WROW09? M{TJb5NmdnOrdHn6[ZMhWGGwY{GgZ4VtdHNiZn;yJIdmdWOrdHHibY5mNWmwZIXj[YQh[XCxcITvd4l{ M2P3elI2QDd{OUSx
Panc1 NXztXGFlS2WubDDWbYFjcWyrdImgRZN{[Xl? NEPqV4QyyqEQvF2= M{m2UlczyqCq M4rBUmROW09? NFvNV|FmdmijbnPld{Bo\W2laYThZolv\S2rbnT1Z4V{KGOnbHygeoli[mmuaYT5JIRm[3KnYYPl M1;EVVI2QDd{OUSx
MMCs MU\GeY5kfGmxbjDBd5NigQ>? MUmxJO69dQ>? Ml3WNE01QCCq NXHmbFF[cW6lcnXhd4V{KE6SUlGgdJJwfGWrbjDlfJBz\XO|aX;uxsAzNjgkgKOzMlUh\m:uZB?= MnfGNlQ1PTF|N{i=
MMCs MXnGeY5kfGmxbjDBd5NigQ>? MWCwMlUwOSEQvF2= MYmyOEBp M3fqTZNpd3e|IES1MYZwdGRic4TpcZVt[XSrb36gbY4h[0ePUDDs[ZZmdHN? M3m3OlI1PDVzM{e4
MMCs MkX3SpVv[3Srb36gRZN{[Xl? NXjYcGdyOcLizszN MVmyOEBp NYLaVpUzcW6lcnXhd4V{KEiDVDDhZ5Rqfmm2eR?= M3\XXVI1PDVzM{e4
MMCs NUi2VI9TTnWwY4Tpc44hSXO|YYm= Ml;aNeKh|ryP NFLrNo8zPCCq MXHheYdu\W62czDncI9j[WxiYXPleJlt[XSrb36gcIV3\Wy|IH;mJIhqe3SxbnWgTFMuUzlxMUSgLGg{NUt7L{G0ZYMqKGGwZDDIOE1MOTJiKFi0MWsyOmGlKR?= NELWTpUzPDR3MUO3PC=>
MMCs MWrGeY5kfGmxbjDBd5NigQ>? MkfQNeKh|ryP M{foXFYuOjRiaB?= NXLXW2Vb\G:|ZT3k[ZBmdmSnboTsfUBqdmirYnn0d{B1cGVidILpcYV1cHmuYYTpc44hdGW4ZXygc4YhUDNvS{mgLGg{NUt7bXWzLS=> NEXaSYIzPDR3MUO3PC=>
BxPC-3 NEHhe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDlUGJnTUN3ME2xMlEh|ryP NFHpPWgzOTN5NU[3PS=>
AsPC-1 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfFR|UxRTNwOTFOwG0> NEOwO24zOTN5NU[3PS=>
MiaPaca-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXFR|UxRTBwNjFOwG0> NWn4RpJ[OjF|N{W2O|k>
Panc-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nubGVEPTB;MT64JO69VQ>? NFruSXEzOTN5NU[3PS=>
PAXF 546L† NIrqS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuxSWM2OD1zLkWg{txO NGDWO4YzOTN5NU[3PS=>
PAXF 1657L† NHLaTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLFR|UxRTBwMzFOwG0> MlvYNlE{PzV4N{m=
HCT15 NF\xb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPvRldvUUN3ME2wMlch|ryP M3j3blIyOzF5NEW1
HT-29 NY\CS3g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNzFOwG0> NXTEZlN4OjF|MUe0OVU>
SW48 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TmVWlEPTB;MD64JO69VQ>? MnzCNlE{OTd2NUW=
SW620 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFizszN NInkfGMzOTNzN{S1OS=>
HMEC NF6xeFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK1VnVKSzVyPUG5JO69VQ>? M{LCUVIyOzF5NEW1
ANBL6  MVrGeY5kfGmxbjDBd5NigQ>? NF;4e3cyyqEQvF2= NXTHSox4OjRiaB?= M1y1WIVvcGGwY3XzJFUuSUNvaX7keYNm\CCPQVfFMWE{KGenbnWg[ZhxemW|c3nvci=> M{jFU|IyOTdzOEKx
LP1 M3H3fWZ2dmO2aX;uJGF{e2G7 MmjyNeKh|ryP NGjYNlYzPCCq MXflcohidmOnczC1MWFENWmwZIXj[YQhVUGJRT3BN{Bo\W6nIHX4dJJme3Orb36= MkT6NlEyPzF6MkG=
HD-LM2 NYjDfJU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVS3NuKhcA>? NUf0WItbTE2VTx?= NXjQc5ZYUUN3ME2xMlg5KM7:TR?= NWCwUIF6OjB6OECxNFc>
L428 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[3NuKhcA>? NUPvXolLTE2VTx?= NYmzT5dbUUN3ME2xMlk3KM7:TR?= NXrDc2FwOjB6OECxNFc>
KM-H2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPhVm1{PzMEoHi= M1jtTmROW09? MmDITWM2OD1{Lki2JO69VQ>? MnjKNlA5QDBzMEe=
HD-LM2 NIHaPXpHfW6ldHnvckBCe3OjeR?= MWGwMlEuOiEQvF2= NGDNNGYzPCCqwrC= M1PKW2ROW09? MlTHd4hwf3NiYXPleJlt[XSrb36gc4YhcGm|dH;u[UA{KGGwZDD1dJJm\3WuYYTpc44hd2ZidHjlJINmdGxiY4njcIUhemWpdXzheI9zgSCycn;0[YlvKHB{MR?= NGe5e3UzODh6MEGwOy=>
L428 M1POb2Z2dmO2aX;uJGF{e2G7 NGXRTXYxNjFvMjFOwG0> MorqNlQhcMLi M2CxbGROW09? MYnzbI94eyCjY3X0fYxifGmxbjDv[kBpcXO2b37lJFMh[W6mIIXwdoVofWyjdHnvckBw\iC2aHWgZ4VtdCCleXPs[UBz\We3bHH0c5J6KHC{b4TlbY4heDJz M{\jTFIxQDhyMUC3
KM-H2 NGq5SFBHfW6ldHnvckBCe3OjeR?= MnzYNE4yNTJizszN NGDQeG8zPCCqwrC= NHjkS3ZFVVOR NX\aeJpEe2ixd4OgZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SB|IHHu[EB2eHKnZ4XsZZRqd25ib3[geIhmKGOnbHygZ5lkdGVicnXneYxifG:{eTDwdo91\WmwIICyNS=> NHzMXYkzODh6MEGwOy=>
HD-LM2 NYPhPXBySXCxcITvd4l{KEG|c3H5 NEXWSZcxNjFxMD61M|Eh|ryP NIHKPZI1QCCq MXjEUXNQ MX7pcoR2[2W|IHHwc5B1d3OrczDkc5NmKGSncHXu[IVvfGy7 MYSyNFg5ODFyNx?=
L428 MnPDRZBweHSxc3nzJGF{e2G7 M2TSelAvOS9yLkWvNUDPxE1? MWO0PEBp MX3EUXNQ M2nTcYlv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NFTYXWUzODh6MEGwOy=>
KM-H2 MUnBdI9xfG:|aYOgRZN{[Xl? NUXOeYRyOC5zL{CuOU8yKM7:TR?= NHTWXZg1QCCq M2SxXWROW09? MoTDbY5lfWOnczDhdI9xfG:|aYOg[I9{\SCmZYDlcoRmdnSueR?= M1u2UlIxQDhyMUC3
HD-LM2 M1u3XmZ2dmO2aX;uJGF{e2G7 Ml6wNeKh|ryP NHfnfIMzPC92ODDo NHXKWFlFVVOR NWK2UVd7\G:5boLl[5Vt[XSnczDYTWFRNCCjY4TpeoF1\WRiY3HzdIF{\XNiOTDhcoQhOw>? M1ryRVIxQDhyMUC3
L428 Mlj6SpVv[3Srb36gRZN{[Xl? NWD4TnlZOcLizszN NG\tfGozPC92ODDo NInlPINFVVOR Ml;v[I94dnKnZ4XsZZRmeyC[SVHQMEBi[3SrdnH0[YQh[2G|cHHz[ZMhQSCjbnSgNy=> Ml;xNlA5QDBzMEe=
KM-H2 Mmq1SpVv[3Srb36gRZN{[Xl? M3K0W|HDqM7:TR?= Mlq3NlQwPDhiaB?= NHvPdJVFVVOR NG\mbWNld3ewcnXneYxifGW|IGjJRXAtKGGldHn2ZZRm\CClYYPwZZNmeyB7IHHu[EA{ Mn;5NlA5QDBzMEe=
HD-LM2 M2XVO2Z2dmO2aX;uJGF{e2G7 NGLVRXUxNjVxMTFOwG0> Mn36NlQwPDhiaB?= M3HPTmROW09? MYj1dJJm\3WuYYTld{BVVkZvzsGg[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= MlvpNlA5QDBzMEe=
L428 MXTGeY5kfGmxbjDBd5NigQ>? MYWwMlUwOSEQvF2= NETZVZYzPC92ODDo M1XCRmROW09? MY\1dJJm\3WuYYTld{BVVkZvzsGg[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= Mor5NlA5QDBzMEe=
KM-H2 MWjGeY5kfGmxbjDBd5NigQ>? NEP4W3kxNjVxMTFOwG0> Mn7YNlQwPDhiaB?= NWL0OYNXTE2VTx?= NYPCVoNNfXC{ZXf1cIF1\XNiVF7GMe6yKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70cJk> MnzlNlA5QDBzMEe=
HD-LM2 NXfWTXY5TnWwY4Tpc44hSXO|YYm= NV;uUJVtOcLizszN M1f3[FAvOjVvNEigbC=> NEfRZoJFVVOR MXrhZ5RqfmG2ZYOgUmYuc0J? MUGyNFg5ODFyNx?=
L428 NHP5b3BHfW6ldHnvckBCe3OjeR?= MV:xxsDPxE1? NXn4WZFzOC5{NT20PEBp MYTEUXNQ MX7hZ5RqfmG2ZYOgUmYuc0J? M2PaeFIxQDhyMUC3
KM-H2 NV7FflF6TnWwY4Tpc44hSXO|YYm= NFnWSXoyyqEQvF2= MVKwMlI2NTR6IHi= MWDEUXNQ MnXEZYN1cX[jdHXzJG5HNWuE M2LKV|IxQDhyMUC3
H526 NU\rVW46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHITWM2OD12OECgcm0> MmHzNlA3QDJ4NEO=
H146 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\5TXNsUUN3ME2zOUBvVQ>? NUX2PGVzOjB4OEK2OFM>
H82 NVfTZ2FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnsfXNKSzVyPUK1NEBvVQ>? MXGyNFY5OjZ2Mx?=
DMS114 NHPUeGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZ2MDDuUS=> MVuyNFY5OjZ2Mx?=
HeLa MoizSpVv[3Srb36gRZN{[Xl? MU[wMlMuOTBizszN MWG4JIg> M3LsbGROW09? NYf2eHlwcW6lcnXhd4V{KGGlZYT5cIF1\WRiSEOgT|khMEh|S{nBZ{kh[XRiMUCg{txO M1ftUVIxPTN6OESw
HeLa MlvxSpVv[3Srb36gRZN{[Xl? MorGNE4{NTFyIN88US=> MljNPEBp MXjEUXNQ M3noZolv[3KnYYPld{Bk[XOyYYPlJFMh[W6mIEegZYN1cX[jdHnvckBld3OnIHTldIVv\GWwdHz5 NXfqelJWOjB3M{i4OFA>
HeLa NHfFR|BHfW6ldHnvckBCe3OjeR?= MVmxNEDPxE4EoB?= MWi2M|EzNzJ2IHi= NILWblVFVVOR MYPpcoR2[2W|IH3peI91cWNiYXPjeY12dGG2aX;uJIFv\CCmZXzhfYVlKHB{MTDlfJBz\XO|aX;u MmDzNlA2Ozh6NEC=
HeLa  MYfGeY5kfGmxbjDBd5NigQ>? MYmxNEDPxE4EoB?= NX2wRXZrPyCq NYn5R3pYTE2VTx?= MmXG[Il{enWydIOgco9zdWGuIIPwbY5ldGViY3jlZ4txd2mwdDDmeY5kfGmxbh?= MnLkNlA2Ozh6NEC=
PBMC  M3K0WGFxd3C2b4Ppd{BCe3OjeR?= MXWwMlUwOi9|IN88US=> MUGyOE81QCCq Mke2bY5lfWOnczDhdI9xfG:|aYOg[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NUHOcmpqOjB2ME[5OFc>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-H3 / Ac-H4 / Ac-tubulin ; 

PubMed: 29186204     


Mocetinostat increased acetylated histone 3 and 4 in a time- and dose-dependent manner in LMS cells. Mocetinostat did not increase acetylated tubulin expression.

Bad / Bid / Bak / Puma / Bax / Cleaved caspase-9 / Cleaved caspase-3 / Cleaved PARP; 

PubMed: 27551526     


(a and b) DU-145 cells were treated with various doses of mocetinostat for 24 h. Western blotting was performed using the indicated antibodies. 

29186204 27551526
Immunofluorescence
Nanog / MHC ; 

PubMed: 26240433     


c-Kit+ cells were treated with 2 µM MOCE for 2 or 7 days, as indicated. The cells were double-labeled with anti-Nanog (green) and anti-αMHC (red) antibodies. Nuclei were stained with DAPI (blue). The upper right section of each panel shows the enlargement of the box-selected area. Scale bars = 20 µm.

E-cadherin / ZEB1 ; 

PubMed: 25872941     


Immunoblot and immunofluorescence showing that mocetinostat treatment (1 μM, 48 h) reduced ZEB1 expression and induced E-cadherin in Panc1. Expression of histone deacetylases was not altered by mocetinostat, but histone acetylation was induced. Scale bar 10 μm.

26240433 25872941
Growth inhibition assay
Cell viability; 

PubMed: 26378038     


B. Cells were treated with increasing concentrations of mocetinostat for 48 hours and assayed by the WST-1 cell viability assay. C. IC50 values were calculated by the GraphPad Prism software. 

26378038
In vivo MGCD0103 significantly inhibites growth of human tumor xenografts in nude mice and the antitumor activity correlated with induction of histone acetylation in tumors. P.O. administration of MGCD0103 (2HBr salt) significantly decreases growth of implanted advanced A549 tumors in nude mice in a dose-dependent manner after 13 days of daily administration. MGCD0103 (170 mg/kg for 2HBr salt, corresponding to 120 mg/kg of free base) significantly blockes growth of tumors compared with vehicle treatment alone with no change in body weight. In addition, MGCD0103 does not reduce WBC counts and is well tolerated. MGCD0103 is also orally active in many other human tumor xenograft models including NSCLC H1437. MGCD0103 at 80 mg/kg (free base) almost completely blocks the growth of H1437 tumors after 13 days of daily p.o. administration with no reduction of body weight in animals. [1] MGCD0103 reduces pulmonary arterial pressure more dramatically than tadalafil, a standard-of-care therapy for human pulmonary hypertension that functions as a vasodilator. Moreover, MGCD0103 improves pulmonary artery acceleration time and reduced systolic notching of the pulmonary artery flow envelope, which suggests a positive impact of the HDAC inhibitor on pulmonary vascular remodeling and stiffening. [2]

Protocol

Kinase Assay:[1]
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HDAC enzyme assay in vitro:

The deacetylase enzyme assay is based on a homogeneous fluorescence release assay. Purified recombinant HDAC enzymes are incubated with MGCD0103 diluted in various concentrations for 10 minutes in assay buffer [25 mM HEPES (pH 8.0), 137 mM NaCl, 1 mM MgCl2, 2.7 mM KCl] at room temperature. The substrate Boc-Lys(ε-Ac)-AMC is added to the reaction for further incubation at 37 °C. The concentration of the substrate and the incubation time varies for different isotypes of HDAC enzymes. A 20-min trypsin incubation at room temperature allows the release of the fluorophore from the deacetylated substrate. The fluorescent signal is detected by fluorometer at excitation of 360 nm, emission of 470 nm, and cutoff at 435 nm.
Cell Research:[1]
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  • Cell lines: Human mammary epithelial cells (HMEC), human foreskin fibroblasts (MRHF) cells
  • Concentrations: 0-60 μM
  • Incubation Time: 72 hours
  • Method: Human mammary epithelial cells (HMEC) and human foreskin fibroblasts (MRHF) cells in 96-well plates are incubated with MGCD0103 at various concentrations for 72 hours at 37 °C in 5% CO2. MTT is added at a final concentration of 0.5 mg/ml and incubated with the cells for 4 hours before an equal volume of solubilization buffer [50% N,N-dimethylformamide, 20% SDS (pH 4.7)] is added. After overnight incubation, solubilized dye is quantified by reading at 570 nm using a reference at 630 nm. Absorbance values are converted to cell numbers according to a standard growth curve of the relevant cell line. The concentration which reduces cell numbers to 50% relative to DMSO-treated cells is determined as MTT IC5
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: Female CD-1 nude mice bearing H1437 tumors
  • Formulation: PBS acidified with 0.1 M HCl or PEG400/0.2 M HCl saline, 40:60
  • Dosages: 80 mg/kg
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 13 mg/mL (32.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% Propylene glycol
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 396.44
Formula

C23H20N6O

CAS No. 726169-73-9
Storage powder
in solvent
Synonyms MG0103

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02993991 Withdrawn Drug: Mocetinostat|Biological: Durvalumab Squamous Cell Carcinoma Head And Neck|Squamous Cell Carcinoma Mouth|Resectable Squamous Cell Carcinoma of Oral Cavity University Health Network Toronto|Mirati Therapeutics Inc.|AstraZeneca October 10 2017 Phase 1
NCT02805660 Active not recruiting Drug: mocetinostat|Drug: durvalumab Advanced Cancer Mirati Therapeutics Inc. May 2016 Phase 1|Phase 2
NCT02236195 Completed Drug: Mocetinostat Urothelial Carcinoma Mirati Therapeutics Inc. October 2014 Phase 2
NCT00666497 Terminated Drug: Azacitidine|Drug: MGCD0103 Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS) Mirati Therapeutics Inc. June 2008 Phase 2
NCT00511576 Terminated Drug: MGCD0103 & Docetaxel Breast Cancer|Lung Cancer|Pulmonary Cancer|Non-Small-Cell Lung Carcinoma|Prostate Cancer|Prostatic Cancer|Gastric Cancer|Stomach Cancer Mirati Therapeutics Inc. August 2007 Phase 1

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Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID