Tubastatin A TFA

For research use only.

Catalog No.S0709 Synonyms: Tubastatin A trifluoroacetate salt

Tubastatin A TFA Chemical Structure

CAS No. 1239262-52-2

Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.

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Biological Activity

Description Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.
Targets
HDAC6 [1]
(Cell-free assay)
15 nM

Protocol

Solubility (25°C)

In vitro DMSO 40 mg/mL (89.0 mM)
Water 5 mg/mL (11.12 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 449.42
Formula

C22H22F3N3O4

CAS No. 1239262-52-2
Storage powder
in solvent
Synonyms Tubastatin A trifluoroacetate salt
Smiles CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.C(=O)(C(F)(F)F)O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID