Ruxolitinib Phosphate

For research use only.

Catalog No.S5243 Synonyms: INCB018424, INC424

123 publications

Ruxolitinib Phosphate Chemical Structure

CAS No. 1092939-17-7

Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Selleck's Ruxolitinib Phosphate has been cited by 123 publications

Purity & Quality Control

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Biological Activity

Description Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
Targets
JAK2 [1]
(Cell-free assay)
JAK1 [1]
(Cell-free assay)
2.8 nM 3.3 nM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf21 NYPaWZZCTnWwY4Tpc44h[XO|YYm= MYWxJIhz MVTJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczD1d4lv\yCHUVXESXBGT0S\RlXXUGUh[XNic4Xid5Rz[XSnIHHmeIVzKDFiaIKgZpkhUFSURjDhd5NigSxiSVO1NF0xNjByMklOwG0> MkXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OUG0NFIoRjJ{NUmxOFAzRC:jPh?=
Sf21 MVPGeY5kfGmxbjDhd5NigQ>? M3:2SVEhcHJ? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGpCUzFia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczD1d4lv\yCHUVXESXBGT0S\RlXXUGUh[XNic4Xid5Rz[XSnIHHmeIVzKDFiaIKgZpkhUFSURjDhd5NigSxiSVO1NF0xNjByM{ROwG0> NEHoTng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW5NVQxOid-MkK1PVE1ODJ:L3G+
Sf21 NV7HZ5RTTnWwY4Tpc44h[XO|YYm= NX;zb|c4OSCqch?= M3Tab2lvcGmkaYTpc44hd2ZiaIXtZY4hXFmNMjDrbY5ie2ViZH;tZYlvKGW6cILld5Nm\CCrbjDT[lIyKGOnbHzzJJV{cW6pIFXRSWRGWEWJRGnGSXdNTSCjczDzeYJ{fHKjdHWgZYZ1\XJiMTDodkBjgSCKVGLGJIF{e2G7LDDJR|UxRTBwMEG5{txO MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7MUSwNkc,OjJ3OUG0NFI9N2F-
Sf21 NV3GdJhWTnWwY4Tpc44h[XO|YYm= NGnycFMyKGi{ Mmi4TY5pcWKrdHnvckBw\iCqdX3hckBLSUt|IHvpcoF{\SCmb33hbY4h\XiycnXzd4VlKGmwIGPmNlEh[2WubIOgeZNqdmdiRWHFSGVRTUeGWV\FW2xGKGG|IIP1ZpN1emG2ZTDh[pRmeiBzIHjyJIJ6KEiWUl[gZZN{[XluIFnDOVA:OC52MklOwG0> NWnKWopGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1PVE1ODJpPkKyOVkyPDB{PD;hQi=>
TF1 NFvVNlFHfW6ldHnvckBie3OjeR?= MUWyNEBucW6| MnXWTY5pcWKrdHnvckBw\iCMQVuyJIlvKGi3bXHuJHRHOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGVRVy2rbnT1Z4VlKFOWQWS1JJBpd3OyaH;yfYxifGmxbjDpcoN2[mG2ZXSg[o9zKDJyIH3pcpMheHKrb4KgeI8hTVCRLXnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB|MDD0c{A1PSCvaX7zMEBGSzVyPUCuNFEz|ryP NFrWTZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5PFA5PCd-MkK2PVgxQDR:L3G+
TF1 NEDT[IdHfW6ldHnvckBie3OjeR?= M{nDelIxKG2rboO= NYn6dGM{UW6qaXLpeIlwdiCxZjDKRWsyKGmwIHj1cYFvKFSIMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEmONj3pcoR2[2WmIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBqdmO3YnH0[YQh\m:{IEKwJI1qdnNicILpc5IhfG9iSVy2MYlv\HWldHnvckBu\WG|dYLl[EBi\nSncjCzNEB1dyB2NTDtbY5{NCCHQ{WwQVAvODJ2zszN NILxSIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5PFA5PCd-MkK2PVgxQDR:L3G+
SET2 MWjGeY5kfGmxbjDhd5NigQ>? M3fTZ2lvcGmkaYTpc44hd2ZiSlHLNkBXPjF5RjDteZRidnRiaX6gbJVu[W5iU1XUNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iU2TBWFUheGixc4Doc5J6dGG2aX;uMEBKSzVyPUCuNFAyQDUQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MU[2NEc,OjNyNkG2OlA9N2F-
TF1 NE\keINHfW6ldHnvckBie3OjeR?= M2PWSFMxKG2rboO= NWLLZ4VqUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKFSIMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hW1SDVEWgdIhwe3Cqb4L5cIF1cW:wIHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BqdiCycnXz[Y5k\SCxZjDoeY1idiC{ZXPvcYJqdmGwdDDFVG8tKEmFNUC9NE4xODZ6Nd88US=> M{HGNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xOlYxLz5{M{C2NVY3ODxxYU6=
T-cells MXjGeY5kfGmxbjDhd5NigQ>? NYi0UmlDUW6qaXLpeIlwdiCxZjDKRWs{NzFiaX6gbJVu[W5iVDDj[YxteyCneIDy[ZN{cW6pIFPEN{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOi2|dHnteYxifGWmIGPURXQ2[SCyaH;zdIhwenmuYYTpc44tKEmFNUC9NE4xOjQQvF2= NVPtNpA6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OFA3PDhpPkKzOVQxPjR6PD;hQi=>
T-cells Mor2SpVv[3Srb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKEqDS{KvNUBqdiCqdX3hckBVKGOnbHzzJIV5eHKnc4PpcochS0R|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiSV\O[4FudWFvc4TpcZVt[XSnZDDTWGFVOSCyaH;zdIhwenmuYYTpc44tKEmFNUC9NE4xOzIQvF2= NYfoWoVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OFA3PDhpPkKzOVQxPjR6PD;hQi=>
Sf9 MXHGeY5kfGmxbjDhd5NigQ>? MYCxJIhz MYHJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJiKEiyPE0yOTN{KTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNvaX7m[YN1\WRiU3[5JINmdGy|IIXzbY5oKEWTRVTFVGVITFmIRWfMSUBieyC|dXLzeJJifGViYX\0[ZIhOSCqcjDifUBJXFKIIHHzd4F6NCCNaU2wMlAxODIQvF2= NYPBcXJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2Olg1QDRpPkKzOlY5PDh2PD;hQi=>
Sf9 M3fUcGZ2dmO2aX;uJIF{e2G7 M3PVc|EhcHJ? NX2zU|M4UW6qaXLpeIlwdiCxZjDoeY1idiCMQVuxJEg5OzdvMUG0Nkkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJHNnQSClZXzsd{B2e2mwZzDFVWVFTVCHR1TZSmVYVEViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygT4k:OC5yMECy{txO Mn;EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4Nki0PFQoRjJ|Nk[4OFg1RC:jPh?=
Sf9 NETJNHNHfW6ldHnvckBie3OjeR?= M2DVTFEhcHJ? NVfudpBbUW6qaXLpeIlwdiCxZjDoeY1idiCWWVuyJEg5PzNvMUG4O{kh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJHNnQSClZXzsd{B2e2mwZzDFVWVFTVCHR1TZSmVYVEViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygT4k:OC5yMEC1{txO NVXISYlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2Olg1QDRpPkKzOlY5PDh2PD;hQi=>
Sf9 NUfjcZZWTnWwY4Tpc44h[XO|YYm= NGTlNGUyKGi{ MUXJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzNiKEe4NU0yOTJ2KTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNvaX7m[YN1\WRiU3[5JINmdGy|IIXzbY5oKEWTRVTFVGVITFmIRWfMSUBieyC|dXLzeJJifGViYX\0[ZIhOSCqcjDifUBJXFKIIHHzd4F6NCCNaU2wMlAxOzMQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ4OES4OEc,OjN4Nki0PFQ9N2F-
CD34+ MWXGeY5kfGmxbjDhd5NigQ>? MVG0OUBucW6| NU\HW405UW6qaXLpeIlwdiCxZjDKRWszKGixbX;kbY1meiCrbjDoeY1idiCFREO0L{Bk\WyuczDzdIls\WRiaX70c{BpfW2jbjD3bI9t\SCkbH;v[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGVRVy2rbnT1Z4VlKFOWQWStOUBxcG:|cHjvdplt[XSrb36gdJJmcW6ldXLheIVlKG[xcjC0OUBucW6|IH\vcIxwf2WmIHL5JGVRVyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyPSCvaX7zJIJ6KE[DQ2OgZY5idHm|aYOsJGlEPTB;MD62O|fPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzN{WzN{c,OjR2MUe1N|M9N2F-
BA/F3 NGDFRoJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3H6PFczKGi{cx?= NY\4[mJ1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKFSHTD3KRWsyKGGodHXyJFczKGi{czDifUBk\WyuIITpeIVzKGeubzDhd5NigQ>? NEj4bYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
BA/F3 NHu5TpFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NH\ROGc4OiCqcoO= NEPHcldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochXEWOLVrBT|Ih[W[2ZYKgO|IhcHK|IHL5JINmdGxidHn0[ZIh\2yxIHHzd4F6 NIXiXYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
TALL-1 NHXVZpZHfW6ldHnvckBie3OjeR?= NFXRSWQyKHWP MWizJIhzew>? NGLqSGxKdmirYnn0bY9vKG:oIFrBT|MhcW5iaIXtZY4hXEGOTD2xJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiSVytNkBqdmS3Y3XkJHNVSVR3IIDoc5NxcG:{eXzheIlwdiCjdDCxJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOyCqcoOg[o9tdG:5ZXSgZpkhUUxvMjDpcoR2[3Srb36gcYVie3W{ZXSgZYZ1\XJiM{CgcYlveyCkeTDpcY12dm:kbH;0eIlv\w>? NIT0cG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
OCL-AML5 MVrGeY5kfGmxbjDhd5NigQ>? MYOxJJVO MVizJIhzew>? M{T6NGlvcGmkaYTpc44hd2ZiSlHLNkBqdiCqdX3hckBQS0xvQV3MOUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFfNMWNUTiCrbnT1Z4VlKFOWQWS1JJBpd3OyaH;yfYxifGmxbjDheEAyKHWPIIDy[Ylv[3WkYYTl[EBnd3JiMzDodpMh\m:ubH;3[YQh[nliR12tR3NHKGmwZIXjeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zJIJ6KGmvbYXuc4Jtd3S2aX7n NYrMOXlGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVg2OjFpPkK2NlU5PTJzPD;hQi=>
CD34+ NEf3VY1HfW6ldHnvckBie3OjeR?= M4PGVGlvcGmkaYTpc44hd2ZiSlHLNkBqdiCqdX3hckBETDN2KzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEWSTz3t[YRq[XSnZDDj[YxtKHC{b3zp[oVz[XSrb36sJGlEPTB;MD6wNFjPxE1? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{N{SyN{c,OjZ7Mke0NlM9N2F-
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PBMC NGPPS5NHfW6ldHnvckBie3OjeR?= MoriTY5pcWKrdHnvckBKVC15LXnu[IN2\WRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJHBDVUNiY3XscJMh[nliZnzve{BkgXSxbXX0dpktKEmFNUC9NE41PDkQvF2= M4jsXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUK3OFI{Lz5{NkmyO|QzOzxxYU6=
Sf21 MYLGeY5kfGmxbjDhd5NigQ>? Mn7MOlAhdWmwcx?= Mn;VTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCMQVuyJIV5eHKnc4Pl[EBqdiCVZkKxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCXbHnnbJQuS0GJQVfBTWVVTEuHWWnUWmtFKHCqb4PwbI9zgWyjdHnvckBxemVvaX7jeYJifGWmIHLl[o9z\SC|dXLzeJJifGViYXTkbZRqd25iYX7kJI1m[XO3cnXkJIFnfGW{IE[wJI1qdnNiYomgUGFPS0ViZHX0[YN1cW:wIH3leIhw\CxiSVO1NF0xNjByM988US=> MlvPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{ezOVkoRjJ5MUO3N|U6RC:jPh?=
Sf21 NYTjW5JiTnWwY4Tpc44h[XO|YYm= NULZfJVIOSCqch?= NFm4cGtKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFOteIVzdWmwYXygOmhqey22YXfn[YQhUkGNMjCoPFA5KHSxIHXu[EBidWmwbzDhZ4lleyliZYjwdoV{e2WmIHnuJHNnOjFiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgNUBpeiCrbjDwdoV{\W6lZTDv[kBCXFBiYomgWHIuTlKHVDDhd5NigSxiSVO1NF0xNjByNEJOwG0> M1exO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUW1Nlg1Lz5{N{W1OVI5PDxxYU6=
BaF3 NH36Z5pHfW6ldHnvckBie3OjeR?= M1fY[GlvcGmkaYTpc44hd2ZiSlHLNkBXPjF5RjDteZRidnRiZYjwdoV{e2WmIHnuJI1wfXOnIFLhSlMh[2WubIOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBGSzVyPUCuNVg3|ryP MmjoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUWyPFQoRjJ5NUW1Nlg1RC:jPh?=
HEL 92.1.7 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2G2V|Mh\GG7cx?= NFfuZ2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhGVCB7Mj6xMlch[2WubIOgZZN{\XO|ZXSgZZMhfmmjYnzlJINmdGy|IH3lZZN2emWmIHHmeIVzKDNiZHH5d{BjgSCZU2StNUBie3OjeTygTWM2OD1zND63{txO MlzVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUWyPFQoRjJ5NUW1Nlg1RC:jPh?=
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Sf9 Mn3CSpVv[3Srb36gZZN{[Xl? M1jnSFMxKHOnY4O= MoPOTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCFLYTldo1qdmGuIHjlfIFpcXO2aXTpcoUhfGGpZ3XkJGpCUzNiSlixJINifGGueYTpZ{Bld22jaX6gLFgyOSC2bzCxNVI1KHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW2Z7IHPlcIx{KHW|aX7nJHR6ejZicHXweIll\SCjczDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiB|MDDz[YN{KHWwZHXyJJNp[WurbnegZ49v\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIhNCCLQ{WwQVAvODVzzszN NHvyZnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4NVU4QCd-M{C5PFE2Pzh:L3G+
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insect cells M2LDS2Z2dmO2aX;uJIF{e2G7 MnrzNVAhdWmwcx?= M1zZXWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iTj30[ZJucW6jbDDHV3QufGGpZ3XkJGpCUzFiKEi2OkB1dyBzMUW0JJJme2mmdXXzLUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIF\JWGMudGGkZXzl[EBEPi2NS1jUSGRIYU2STWPQS3ZCNU6KIIDldJRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IEGwJI1qdnNiaX6gdJJme2WwY3Wgc4YhPSCvTTDBWHAh[nliY3HsbZBmeiCvb3LpcIl1gSC|aHnmeEBie3OjeTygTWM2OD1yLkCy{txO NHfObGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkK5O|c1Oyd-M{KyPVc4PDN:L3G+
insect cells NIL5e49HfW6ldHnvckBie3OjeR?= NHTySHMyOCCvaX7z MY\Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE5vdHXycYlv[WxiR2PUMZRi\2enZDDKRWszKCh6M{GgeI8hOTF|MjDy[ZNq\HWnczmg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yB3RlHNMYxi[mWuZXSgS2VGWEy\V2PGVGFMU0tvTliyJJBmeHSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFExKG2rboOgbY4heHKnc3XuZ4Uhd2ZiNTDtUUBCXFBiYomgZ4FtcXCncjDtc4JqdGm2eTDzbIlnfCCjc4PhfUwhUUN3ME2wMlAz|ryP NFvNc|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkK5O|c1Oyd-M{KyPVc4PDN:L3G+
BAF3 Mof4R5l1d3SxeHnjbZR6KGG|c3H5 MWO0PEBpenN? M{XWd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCTjNiY3XscJMh\XiycnXzd4lv\yCMQVuyJHY3OTeIIH31eIFvfCCjZoTldkA1QCCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCLQ{WwQVAvOTJ4zszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxO|g6QTRzLze+R4hGVUKOPD;hQi=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 80 mg/mL (197.84 mM)
Water 29 mg/mL (71.71 mM)
Ethanol 8 mg/mL (19.78 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.36
Formula

C17H18N6.H3O4P

CAS No. 1092939-17-7
Storage powder
in solvent
Synonyms INCB018424, INC424
Smiles C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02596347 Completed Procedure: Blood draw|Procedure: bronchoscopy Chronic Beryllium Disease (CBD)|Beryllium Sensitization (BeS) National Jewish Health April 2015 --
NCT01787552 Completed Drug: LDE225|Drug: INC424 Primary Myelofibrosis|Thrombocytosis|Essential Thrombocythemia|Polycythemia Vera|Myeloproliferative Disorders|Bone Marrow Diseases|Hematologic Diseases|Blood Coagulation Disorders|Blood Platelet Disorders|Hemorrhagic Disorders Novartis Pharmaceuticals|Novartis May 8 2013 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

JAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID