Ruxolitinib Phosphate

Catalog No.S5243 Synonyms: INCB018424, INC424

For research use only.

Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Ruxolitinib Phosphate Chemical Structure

CAS No. 1092939-17-7

Selleck's Ruxolitinib Phosphate has been cited by 163 publications

Purity & Quality Control

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Biological Activity

Description Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
Targets
JAK2 [1]
(Cell-free assay)
JAK1 [1]
(Cell-free assay)
2.8 nM 3.3 nM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf21 MofISpVv[3Srb36gZZN{[Xl? MU[xJIhz MUjJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczD1d4lv\yCHUVXESXBGT0S\RlXXUGUh[XNic4Xid5Rz[XSnIHHmeIVzKDFiaIKgZpkhUFSURjDhd5NigSxiSVO1NF0xNjByMklOwG0> NEL5[XI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW5NVQxOid-MkK1PVE1ODJ:L3G+
Sf21 MnexSpVv[3Srb36gZZN{[Xl? MV6xJIhz M1TyVWlvcGmkaYTpc44hd2ZiaIXtZY4hUkGNMTDrbY5ie2ViZH;tZYlvKGW6cILld5Nm\CCrbjDT[lIyKGOnbHzzJJV{cW6pIFXRSWRGWEWJRGnGSXdNTSCjczDzeYJ{fHKjdHWgZYZ1\XJiMTDodkBjgSCKVGLGJIF{e2G7LDDJR|UxRTBwMECzN:69VQ>? NIfVeow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW5NVQxOid-MkK1PVE1ODJ:L3G+
Sf21 MoLzSpVv[3Srb36gZZN{[Xl? M2m3XlEhcHJ? MonTTY5pcWKrdHnvckBw\iCqdX3hckBVYUt{IHvpcoF{\SCmb33hbY4h\XiycnXzd4VlKGmwIGPmNlEh[2WubIOgeZNqdmdiRWHFSGVRTUeGWV\FW2xGKGG|IIP1ZpN1emG2ZTDh[pRmeiBzIHjyJIJ6KEiWUl[gZZN{[XluIFnDOVA:OC5yMUpOwG0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7MUSwNkc,OjJ3OUG0NFI9N2F-
Sf21 MYTGeY5kfGmxbjDhd5NigQ>? MWCxJIhz NX\xeGFSUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuzJItqdmG|ZTDkc41icW5iZYjwdoV{e2WmIHnuJHNnOjFiY3XscJMhfXOrbnegSXFGTEWSRVfEXWZGX0yHIHHzJJN2[nO2cnH0[UBi\nSncjCxJIhzKGK7IFjUVmYh[XO|YYmsJGlEPTB;MD60NljPxE1? NGXQS3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW5NVQxOid-MkK1PVE1ODJ:L3G+
TF1 MkDJSpVv[3Srb36gZZN{[Xl? NGfINnczOCCvaX7z NUCx[ZlyUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKFSIMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEWSTz3pcoR2[2WmIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBqdmO3YnH0[YQh\m:{IEKwJI1qdnNicILpc5IhfG9iRWDPMYlv\HWldHnvckBu\WG|dYLl[EBi\nSncjCzNEB1dyB2NTDtbY5{NCCHQ{WwQVAvODF{zszN M{nKelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Nkm4NFg1Lz5{Mk[5PFA5PDxxYU6=
TF1 NUXvfIRKTnWwY4Tpc44h[XO|YYm= MXyyNEBucW6| NF\IVJFKdmirYnn0bY9vKG:oIFrBT|EhcW5iaIXtZY4hXEZzIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhUUx4LXnu[JVk\WRiU2TBWFMheGixc4Doc5J6dGG2aX;uJIlv[3WkYYTl[EBnd3JiMkCgcYlveyCycnnvdkB1dyCLTE[tbY5lfWO2aX;uJI1m[XO3cnXkJIFnfGW{IEOwJJRwKDR3IH3pcpMtKEWFNUC9NE4xOjUQvF2= NHm1[Zg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5PFA5PCd-MkK2PVgxQDR:L3G+
SET2 NFPMdmtHfW6ldHnvckBie3OjeR?= NUjE[odQUW6qaXLpeIlwdiCxZjDKRWszKFZ4MUfGJI12fGGwdDDpckBpfW2jbjDTSXQzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDTWGFVPSCyaH;zdIhwenmuYYTpc44tKEmFNUC9NE4xODF6NN88US=> M3rQSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xOlYxLz5{M{C2NVY3ODxxYU6=
TF1 MXHGeY5kfGmxbjDhd5NigQ>? NFvJTGY{OCCvaX7z MUPJcohq[mm2aX;uJI9nKEqDS{KgbY4hcHWvYX6gWGYyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDTWGFVPSCyaH;zdIhwenmuYYTpc44hcW6ldXLheIVlKG[xcjCzNEBucW6|IHnuJJBz\XOnbnPlJI9nKGi3bXHuJJJm[2:vYnnuZY51KEWSTzygTWM2OD1yLkCwOlg2|ryP NHHBXGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVY3OCd-MkOwOlE3PjB:L3G+
T-cells MY\GeY5kfGmxbjDhd5NigQ>? Mm\OTY5pcWKrdHnvckBw\iCMQVuzM|EhcW5iaIXtZY4hXCClZXzsd{BmgHC{ZYPzbY5oKEOGMzDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnMNk1{fGmvdXzheIVlKFOWQWS1ZUBxcG:|cHjvdplt[XSrb36sJGlEPTB;MD6wNlPPxE1? M2G5T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUSwOlQ5Lz5{M{W0NFY1QDxxYU6=
T-cells NWnqS|FuTnWwY4Tpc44h[XO|YYm= M1TiVmlvcGmkaYTpc44hd2ZiSlHLNk8yKGmwIHj1cYFvKFRiY3XscJMh\XiycnXzd4lv\yCFREOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJSm5o[W2vYT3zeIlufWyjdHXkJHNVSVRzIIDoc5NxcG:{eXzheIlwdixiSVO1NF0xNjB|Md88US=> MmWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NEC2OFgoRjJ|NUSwOlQ5RC:jPh?=
Sf9 NIqxT4lHfW6ldHnvckBie3OjeR?= M1zGRVEhcHJ? NX:y[|JrUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuyJEg5OjhvMUGzNkkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJHNnQSClZXzsd{B2e2mwZzDFVWVFTVCHR1TZSmVYVEViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygT4k:OC5yMECx{txO MkXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4Nki0PFQoRjJ|Nk[4OFg1RC:jPh?=
Sf9 NFnGSGpHfW6ldHnvckBie3OjeR?= NVfjcFgyOSCqch?= NWO5TW1lUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuxJEg5OzdvMUG0Nkkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJHNnQSClZXzsd{B2e2mwZzDFVWVFTVCHR1TZSmVYVEViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygT4k:OC5yMECy{txO NYLNbVNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2Olg1QDRpPkKzOlY5PDh2PD;hQi=>
Sf9 NVnsPXMxTnWwY4Tpc44h[XO|YYm= NGnDO3gyKGi{ M1W0dWlvcGmkaYTpc44hd2ZiaIXtZY4hXFmNMjCoPFc{NTFzOEepJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3cz3pcoZm[3SnZDDT[lkh[2WubIOgeZNqdmdiRWHFSGVRTUeGWV\FW2xGKGG|IIP1ZpN1emG2ZTDh[pRmeiBzIHjyJIJ6KEiWUl[gZZN{[XluIFvpQVAvODByNd88US=> MkPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4Nki0PFQoRjJ|Nk[4OFg1RC:jPh?=
Sf9 M1[3VmZ2dmO2aX;uJIF{e2G7 NUiwOFV2OSCqch?= NWWwbIMxUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuzJEg4QDFvMUGyOEkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJHNnQSClZXzsd{B2e2mwZzDFVWVFTVCHR1TZSmVYVEViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygT4k:OC5yMEOy{txO NFrF[Yc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2PFQ5PCd-MkO2Olg1QDR:L3G+
CD34+ M1e5Z2Z2dmO2aX;uJIF{e2G7 Mk\mOFUhdWmwcx?= M1;MNmlvcGmkaYTpc44hd2ZiSlHLNkBpd22xZHnt[ZIhcW5iaIXtZY4hS0R|NDugZ4VtdHNic4Dpb4VlKGmwdH:gbJVu[W5id3jvcIUh[myxb3SgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDFVG8ucW6mdXPl[EBUXEGWLUWgdIhwe3Cqb4L5cIF1cW:wIIDy[Ylv[3WkYYTl[EBnd3JiNEWgcYlveyCob3zsc5dm\CCkeTDFVG8h[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVUhdWmwczDifUBHSUOVIHHuZYx6e2m|LDDJR|UxRTBwNke3{txO MmDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUe1N|MoRjJ2NEG3OVM{RC:jPh?=
BA/F3 M2\SOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{[5elczKGi{cx?= NGi5UmhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochXEWOLVrBT|Eh[W[2ZYKgO|IhcHK|IHL5JINmdGxidHn0[ZIh\2yxIHHzd4F6 NH3Yd289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
BA/F3 M2O0NWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIjJUZQ4OiCqcoO= MmLyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJHRGVC2MQVuyJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyJIdtdyCjc4PhfS=> MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NUi1NlEoRjJ4MkW4OVIyRC:jPh?=
TALL-1 MWjGeY5kfGmxbjDhd5NigQ>? Mn;5NUB2VQ>? MYSzJIhzew>? M1P1WGlvcGmkaYTpc44hd2ZiSlHLN{BqdiCqdX3hckBVSUyOLUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCLTD2yJIlv\HWlZXSgV3RCXDVicHjvd5Bpd3K7bHH0bY9vKGG2IEGgeW0heHKnaX7jeYJifGWmIH\vdkA{KGi{czDmc4xtd3enZDDifUBKVC1{IHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGK7IHntcZVvd2Kub4T0bY5o Mn7sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NUi1NlEoRjJ4MkW4OVIyRC:jPh?=
OCL-AML5 NX;mRpJpTnWwY4Tpc44h[XO|YYm= M{nNclEhfU1? NXLGRmtGOyCqcoO= NUHReWFUUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKE:FTD3BUWw2KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gS20uS1OIIHnu[JVk\WRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KDFidV2gdJJmcW6ldXLheIVlKG[xcjCzJIhzeyCob3zsc5dm\CCkeTDHUU1EW0ZiaX7keYN1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliaX3teY5w[myxdITpcoc> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OEWyNUc,OjZ{NUi1NlE9N2F-
CD34+ NGC2W3pHfW6ldHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKEqDS{KgbY4hcHWvYX6gR2Q{PCtiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBGWE9vbXXkbYF1\WRiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEC4{txO NYLZR4VERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5Nlc1OjNpPkK2PVI4PDJ|PD;hQi=>
PBMC M{[2WWZ2dmO2aX;uJIF{e2G7 MnKxTY5pcWKrdHnvckBw\iCMQVuxJIlvKGi3bXHuJHBDVUNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBKVC14LXnu[JVk\WRiTVPQNUB{\WO{ZYTpc44tKEmFNUC9NE4xPM7:TR?= NHTCbGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyO|QzOyd-Mk[5Nlc1OjN:L3G+
PBMC NYDw[4dTTnWwY4Tpc44h[XO|YYm= M3;K[WlvcGmkaYTpc44hUUxvNz3pcoRkfWWmIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBRSk2FIHPlcIx{KGK7IH\sc5ch[3m2b33leJJ6NCCLQ{WwQVAvPDR6zszN MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{N{SyN{c,OjZ7Mke0NlM9N2F-
Sf21 NI[0[HFHfW6ldHnvckBie3OjeR?= M3rDPFYxKG2rboO= NF;l[3ZKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFrBT|Ih\XiycnXzd4VlKGmwIGPmNlEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGXsbYdpfC2FQVfBS2FKTVSGS1XZXXRXU0RicHjvd5Bpd3K7bHH0bY9vKHC{ZT3pcoN2[mG2ZXSgZoVnd3KnIIP1ZpN1emG2ZTDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBNSU6FRTDk[ZRm[3Srb36gcYV1cG:mLDDJR|UxRTBwMECz{txO NELwOYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzO|M2QSd-MkexN|c{PTl:L3G+
Sf21 NX;sd2NsTnWwY4Tpc44h[XO|YYm= NXeye5k1OSCqch?= NEnw[mJKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFOteIVzdWmwYXygOmhqey22YXfn[YQhUkGNMjCoPFA5KHSxIHXu[EBidWmwbzDhZ4lleyliZYjwdoV{e2WmIHnuJHNnOjFiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgNUBpeiCrbjDwdoV{\W6lZTDv[kBCXFBiYomgWHIuTlKHVDDhd5NigSxiSVO1NF0xNjByNEJOwG0> MmK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUWyPFQoRjJ5NUW1Nlg1RC:jPh?=
BaF3 MnHOSpVv[3Srb36gZZN{[Xl? Ml35TY5pcWKrdHnvckBw\iCMQVuyJHY3OTeIIH31eIFvfCCneIDy[ZN{\WRiaX6gcY92e2ViQnHGN{Bk\WyuczDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJGVEPTB;MD6xPFbPxE1? M{C0cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUW1Nlg1Lz5{N{W1OVI5PDxxYU6=
HEL 92.1.7 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NG\kN3Y{KGSjeYO= NF3ZcJBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhGVCB7Mj6xMlch[2WubIOgZZN{\XO|ZXSgZZMhfmmjYnzlJINmdGy|IH3lZZN2emWmIHHmeIVzKDNiZHH5d{BjgSCZU2StNUBie3OjeTygTWM2OD1zND63{txO Mm\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NUWyPFQoRjJ5NUW1Nlg1RC:jPh?=
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Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 404.36
Formula

C17H18N6.H3O4P

CAS No. 1092939-17-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02596347 Completed Procedure: Blood draw|Procedure: bronchoscopy Chronic Beryllium Disease (CBD)|Beryllium Sensitization (BeS) National Jewish Health April 2015 --
NCT01787552 Completed Drug: LDE225|Drug: INC424 Primary Myelofibrosis|Thrombocytosis|Essential Thrombocythemia|Polycythemia Vera|Myeloproliferative Disorders|Bone Marrow Diseases|Hematologic Diseases|Blood Coagulation Disorders|Blood Platelet Disorders|Hemorrhagic Disorders Novartis Pharmaceuticals|Novartis May 8 2013 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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