Nutlin-3a

For research use only.

Catalog No.S8059 Synonyms: (-)-Nutlin-3

49 publications

Nutlin-3a Chemical Structure

CAS No. 675576-98-4

Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 357 In stock
USD 197 In stock
USD 987 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Nutlin-3a has been cited by 49 publications

Purity & Quality Control

Choose Selective Mdm2 Inhibitors

Biological Activity

Description Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
Features Highly selective MDM2 inhibitor with a much lower effect on MDMX. Most effective on tumors with wild type p53.
Targets
p53/MDM2 interaction [3]
(Cell-free assay)
90 nM
In vitro

Nutlin-3a displaces p53 from the binding pocket of MDM2 and thereby releases p53 from inhibition and proteasomal degradation, leading to induction of its downstream targets, cell cycle arrest, and apoptosis. Seven days of incubation with 10 μM nutlin-3a led to >90% inhibition of NIH3T3 cells’ growth[1]. Nutlin-3a stabilizes and activates p53, and induces p21 expression in a dose-dependent manner[1]. Nutlin-3a effectively depletes the S-phase compartment to 0.2-2% and increases the G1- and G2/M-phase compartments[1]. Nutlin-3a induces apoptosis in ~60% of SJSA-1 and MHM cells after 40 h, which increased further after 60 h (85% and 65%, respectively) [1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjIOIJKSzVyPUCuOlEzOzdizszN M2jwUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
H4 M2f2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfwTWM2OD1yLk[2Nlgh|ryP NX\5ZmM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
PA-1 M2TJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG2TWM2OD1yLki3NFk3KM7:TR?= NWXsSWlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NKM-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwMES5N|Eh|ryP MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NEC8 M4TnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonNTWM2OD1zLkKxOVczKM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
EoL-1-cell MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LGWGlEPTB;MT6yOlcxOSEQvF2= NFnCRm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
K5 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzmTWM2OD1zLkSyNFczKM7:TR?= M3TPc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
QIMR-WIL MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7HTWM2OD1zLk[wPFU1KM7:TR?= NInOe|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MOLT-16 NELIN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTRPJgzUUN3ME2xMlc5PjB2IN88US=> M{\ubVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
CHP-212 NFL0PFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PCeGlEPTB;MT64NVM3QSEQvF2= NUPQSpBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CTB-1 NVfVc4NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnZOnQ2UUN3ME2yMlAzOjR4IN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MOLT-4 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjJZYc6UUN3ME2yMlMzQDV|IN88US=> M{e3R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A101D NXLsfpBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[3XZhKSzVyPUKuN|UxOSEQvF2= NFGxb5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
DOHH-2 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X3PGlEPTB;Mj60NlI4QSEQvF2= NFu5ZZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
ES4 NVHOZ5B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jCSGlEPTB;Mj60N|E2PSEQvF2= MnH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SW780 NGHlW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3yzPGlEPTB;Mj61NFg5OyEQvF2= M2rS[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
VA-ES-BJ NYP1bolQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzrO|NKSzVyPUKuOVQyOSEQvF2= NFjjW5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
RPMI-8866 M1KybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNU[yNVQh|ryP MknWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
ML-2 NXfUZ5VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\TOmlEPTB;Mj61OlU4PiEQvF2= NILiUHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MSTO-211H Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rmbWlEPTB;Mj61O|Q2OSEQvF2= Mm\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
JVM-3 M3LUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTKTWM2OD1{LkW5N|I1KM7:TR?= M3\kc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A3-KAW MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TGN2lEPTB;Mj62NVgyQCEQvF2= Mn\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DK-MG M1T4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfPeHlKSzVyPUKuOlI1PzFizszN NE[0UJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
LNCaP-Clone-FGC NV3ocZJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13SVGlEPTB;Mj62OFMyQCEQvF2= NIHSeGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
HT-144 M1XCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPnUFk1UUN3ME2yMlY1PTd5IN88US=> NHK3[o89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NB69 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHhO3VKSzVyPUKuOlU{OzRizszN NX\SWXlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
A172 NYDvRVlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTz[243UUN3ME2yMlY4PTh6IN88US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RS4-11 M1[xNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MomzTWM2OD1{LkeyOFA4KM7:TR?= NHrGTVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
DU-4475 M4fFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nWcmlEPTB;Mj63PVUxOiEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SJSA-1 M3TzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO3dmxKSzVyPUKuPFI2PTZizszN NH65dHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
BV-173 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m2ZWlEPTB;Mj64OFQ{QSEQvF2= M1r1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
U-2-OS NVPTfpluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPlTpNRUUN3ME2yMlkyODdizszN M{Pp[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
CHP-134 M2P4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3eweGlEPTB;Mj65N|g5OiEQvF2= MnLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
D-502MG NY\yW|NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfoTlVKSzVyPUKuPVcyPTRizszN Mn\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
KS-1 M3Haemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3frU2lEPTB;Mz6wNVYzOyEQvF2= M2WzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A204 NYLQO3RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Eb|JuUUN3ME2zMlA2PTh6IN88US=> NGrZTZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
KGN M{ewVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jx[GlEPTB;Mz6wPFQ6PiEQvF2= M1TMfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H292 M3X6eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWyW3AyUUN3ME2zMlEzODJ6IN88US=> NIXWdYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
CAKI-1 NYPCXmdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fDU2lEPTB;Mz6xNlY6PCEQvF2= NGLxdG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
C2BBe1 NFzS[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjmT5MyUUN3ME2zMlE4ODJ4IN88US=> NEfLTmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NB10 M{HXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMkC5OlYh|ryP MnjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MHH-NB-11 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6ZXhKSzVyPUOuNlY5OjdizszN NHKxb5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-SNU-1 NVXJNJBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXtTWM2OD1|LkK3PFQ{KM7:TR?= NGrWSVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
HCT-116 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjROoVKSzVyPUOuN|A{OzVizszN NGP1UGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
G-401 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm1W2tKSzVyPUOuN|Y{OjJizszN MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MN-60 NIXFS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnMelF[UUN3ME2zMlQ1ODl{IN88US=> MojXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SW982 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X2W2lEPTB;Mz61NFg1QCEQvF2= NGDhPYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
RKO Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvxd4tWUUN3ME2zMlU{QTN4IN88US=> NV\aVpM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
D-283MED MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfJZWxKSzVyPUOuOVc6QDZizszN M131b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LB996-RCC NUnIcmJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv6R|BKSzVyPUOuOlI2PThizszN NUi2W|FzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
A549 NFm4N4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrxTlhKSzVyPUOuOlM2PTJizszN MorqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NITEboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jydWlEPTB;Mz62OVcxQCEQvF2= M4nJTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SK-HEP-1 NHnWWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofsTWM2OD1|Lke0Nlk4KM7:TR?= MnnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
G-402 NXzodFJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwOEC4N|Ih|ryP MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
GOTO M4SxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX4TWM2OD1|Lki0N|M{KM7:TR?= NWnxWZhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LOXIMVI M1HrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG0TWM2OD1|Lki1Olc2KM7:TR?= MoPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NH-12 M1Pw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnG5TWM2OD12LkCxPVU6KM7:TR?= NFiyemE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
CTV-1 NWHucJp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG1epBKSzVyPUSuNFc6PzNizszN MnfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CP50-MEL-B M1znSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnxZ2Z1UUN3ME20MlI1Ozl{IN88US=> M3;UblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RH-18 NFjYNWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPXTWM2OD12LkK3O|A3KM7:TR?= NVL4OHRrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NB17 NIC5WIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHaTWM2OD12LkOxO|Y5KM7:TR?= NHvsXXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A375 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KweWlEPTB;ND6zN|UzPCEQvF2= NVfFN3B2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
IST-MES1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwNEG0NVEh|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MZ2-MEL NWTkT|F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\2fZJKSzVyPUSuOVAyPTVizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CAL-54 NYPvUXFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzWRXhKSzVyPUSuOVMxOTlizszN MorpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H28 NFWyT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwNkK3NVch|ryP NEPRcG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
D-247MG MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHoTWM2OD12Lke1NFczKM7:TR?= Mmn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H460 NVvzfGwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOzTWM2OD12LkmxNVI4KM7:TR?= MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MCF7 NHfxVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j2VmlEPTB;NT60OFI1PCEQvF2= Mnr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
697 NX7NfGFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O1TmlEPTB;NT60OFU2KM7:TR?= NVvuW2ZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
ONS-76 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvsTWM2OD13LkW3NFA6KM7:TR?= M2TwelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
C32 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfaTlRxUUN3ME21MlYxODJ7IN88US=> Ml;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
OS-RC-2 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\oXZpJUUN3ME21Mlc{QDh5IN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MEL-HO NUPad497T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvySHZmUUN3ME21Mlg2PjZ5IN88US=> NX3vemNURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LoVo NGXncYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTZwMEG2NlQh|ryP MlzlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
AGS MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L2RmlEPTB;Nj6xOFgzQCEQvF2= NG\obHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GI-ME-N MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOydmxkUUN3ME22MlIzPDJzIN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
H-EMC-SS NGLF[VhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHVfGlmUUN3ME22MlM5PiEQvF2= M4rXVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RVH-421 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTZwNEK0Nlgh|ryP NFntWlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SW954 NUD6TGxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTSWlEPTB;Nj61OVU4OiEQvF2= NFrkO5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NB5 M2\WbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTZwNU[xPFMh|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H2122 NXnXb4xrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXkNIFKSzVyPU[uOVg4QTNizszN M1fNfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
AM-38 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTZwN{W2N|kh|ryP Mmr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
KNS-81-FD M{fSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTZwN{[0PVQh|ryP NGPT[nI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
LS-513 NX;n[HJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTZwN{mwNlYh|ryP M3;VSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A427 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDJOZBKSzVyPU[uPFc5OjlizszN NWDZZmx3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
WM-115 NIT6e4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\iTWM2OD14LkmzNlMh|ryP M2eyRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
COLO-829 Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfHN45jUUN3ME23MlI1OTh6IN88US=> NXvzeIlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H1650 M{fvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfLTHFFUUN3ME23MlM6OjJ6IN88US=> NIP6Omw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H358 M1jGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHqdmtKSzVyPUeuOFQ5PzlizszN NUHzOFVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HT-1080 NHzMPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nuRWlEPTB;Nz60PFI2PCEQvF2= MknJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HCC2218 NHTJbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLmd5BpUUN3ME23MlYzQTdizszN NGLHV|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H661 M2HmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH22b2lKSzVyPUeuPFcxPjlizszN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KM-H2 NUXRUHlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITYS4dKSzVyPUeuPFg3QTRizszN MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RPMI-2650 M3i4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPBSIVLUUN3ME23Mlk1PDF2IN88US=> NVfIe|lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H226 NXPmWog1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRThwMkGxNlIh|ryP NFj1XZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MKN45 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRThwMk[2NFIh|ryP M2\6SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
D-392MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4ZoJ5UUN3ME24MlUzPzJ{IN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RCC10RGB NXTaTG16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLwZY9OUUN3ME24Mlg3Pjl3IN88US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CAL-51 NWrScopiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTtR3hXUUN3ME25MlExOjVzIN88US=> M4HPcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
COLO-678 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLWTWM2OD17LkOyPFEyKM7:TR?= NWDqcnRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
SK-MEL-24 NGXZV3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTEOXhFUUN3ME25MlU2QDV4IN88US=> NVTNeWJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
SK-MEL-30 M2HMVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q2[WlEPTB;OT65OFQ4PiEQvF2= NI\SSoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MMAC-SF M2X4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nzUWlEPTB;MUCuN|k3OSEQvF2= M4DXVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NTERA-S-cl-D1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnsXGtKSzVyPUGwMlY2ODhizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NB12 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzqZWVKSzVyPUGxMlUxOyEQvF2= MnTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
UACC-257 NH:yTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4KzRmlEPTB;MUGuPFY6PSEQvF2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
LAN-6 NWLxWIRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonxTWM2OD1zMT65PVI5KM7:TR?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SW1573 NFL6TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjlR|lKSzVyPUGyMlMxQDZizszN NU\KSJFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NMC-G1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HkfWlEPTB;MUKuOFE4PSEQvF2= M122eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SHP-77 NW\Bb|FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTsTWM2OD1zMj61OVc1KM7:TR?= NUjJSI9ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
IGROV-1 NWq2WYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHHSY9KSzVyPUGyMlY2PzNizszN M3fHd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
22RV1 NUDuNHRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF{LkiwOVkh|ryP NHPQR5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SK-MEL-3 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfnWGtKSzVyPUGzMlM6PzNizszN M1PwWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H1563 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjXTWM2OD1zMz60NlAzKM7:TR?= M1SxblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
IGR-1 NEXrUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF2LkCzOFch|ryP NUDib2VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
EW-3 NX7aU3l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jBV2lEPTB;MUSuNVY{QSEQvF2= NF\P[YQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
JEG-3 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\v[WlEPTB;MUSuOFk2OyEQvF2= NYnMU3dWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
ES3 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD1zND62OVYzKM7:TR?= NITaTWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MDA-MB-175-VII MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF2LkexNVEh|ryP NF7NUJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
P30-OHK NWXDVYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f5NGlEPTB;MUWuNFQ6PiEQvF2= NH60T3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GP5d NYjQSY9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF3LkG0OlYh|ryP NVPkWZpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HMV-II NWjmPYNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfCUXg6UUN3ME2xOU4{OzN|IN88US=> NIe0c4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
COLO-679 M4PJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDjWpNuUUN3ME2xOU42ODFizszN M2THWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
JAR M37adWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLlTWM2OD1zNT63NlA2KM7:TR?= M2PQT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H1666 M1S3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF3LkmzPVkh|ryP M2PjV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SW48 NVHPWXJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T3V2lEPTB;MUWuPVUyPiEQvF2= NV\hUFJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H720 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LDSmlEPTB;MUWuPVk5QSEQvF2= NUG1cVd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HT-1197 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfxeYlKSzVyPUG2MlA{PTJizszN Mn\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HL-60 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3YdWJqUUN3ME2xOk4xOzh2IN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
BEN NVjtWGZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLITWM2OD1zNj61OlM5KM7:TR?= MmX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HAL-01 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rhdmlEPTB;MU[uPFkxQSEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SW900 NXrjVo13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP5WpJKSzVyPUG2MlkyOzJizszN M4rCUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SBC-1 M3HjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjnVGtKSzVyPUG3MlU1OjlizszN M1TtOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SH-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rS[2lEPTB;MUeuOVg1OSEQvF2= NEWwb5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
UACC-62 NXSyc|hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT4TWM2OD1zNz63OlM4KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
BHT-101 NEDTSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv2N5pKSzVyPUG5Mlg4ODVizszN MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
DB NHrjZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\s[ndKSzVyPUKxMlU3PDlizszN NHL5ZXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SK-MEL-1 M1fBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJzLkW4O|Ih|ryP NHTWT3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H747 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnLTWM2OD1{Mj63N|c6KM7:TR?= NHnKWlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SK-LU-1 NWLBW2o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjqZm1yUUN3ME2yN{4{PTJ2IN88US=> NFexc3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
KG-1 NXHlXm57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXGTWM2OD1{Mz60PVQ3KM7:TR?= NXG1[G5jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LXF-289 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTlPZhKSzVyPUKzMlcyPCEQvF2= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
HCC1954 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fhdmlEPTB;MkSuPFg1PCEQvF2= MlfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
Ramos-2G6-4C10 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDpUHlZUUN3ME2yOk41QThzIN88US=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
DBTRG-05MG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHraWGtKSzVyPUK2MlY1QDhizszN M3zI[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H2052 NIC3dnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7yZlN{UUN3ME2yO{42Pjh2IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RMG-I NFrvelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[wTo9KSzVyPUK5MlQyOzlizszN NFPaWG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
H9 M3vYTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNzLkOwNFgh|ryP NYWydJY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
GR-ST MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD1|Mj60OFU{KM7:TR?= Mlj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
Mo-T MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjVZoZjUUN3ME2zNk42ODR4IN88US=> Mo\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SW1088 NULRPJBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPMcnJKSzVyPUOyMlk5ODFizszN NGHQSGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
LB2518-MEL MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe3b29KSzVyPUOzMlA4QTdizszN M1P3TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H82 M1vCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe5Wo5RUUN3ME2zN{4yPjZzIN88US=> NWTvXVRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LAMA-84 M2GxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2L5bGlEPTB;M{SuOlA4OyEQvF2= M3z3NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
KYSE-450 NXH3PFVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWWxW294UUN3ME2zOE43Pzd4IN88US=> M{fIRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LU-99A M1;5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj4OlhKSzVyPUO1MlAxODdizszN MnKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
BE-13 NX\5[pFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN3Lk[1OFUh|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
GAK NXW5NHZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTN3Lk[5OUDPxE1? M4\ZbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H1573 Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTN3Lki4NVgh|ryP NX7RRZp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
AsPC-1 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTN4LkG1Nlch|ryP NEXhUJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
HDLM-2 NHrpPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInPdo9KSzVyPUO2MlMyPiEQvF2= MmnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H441 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTVTWM2OD1|Nz6wOlkyKM7:TR?= NX;BZ49IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CAL-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnTcIg1UUN3ME2zO{44OjNzIN88US=> M3\JUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
OVCAR-3 M3HhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfT[29qUUN3ME2zPU4{OThzIN88US=> M1LEb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RPMI-8226 NYTES2ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTN7LkW5PEDPxE1? MkXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
EFO-21 M1SwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnvVI84UUN3ME20NE42QDF2IN88US=> MmPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SNU-C2B MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTRzLkWwPFQh|ryP NUTvfHBrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
VM-CUB-1 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR|LkiwN|ch|ryP NGLmcZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H2087 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rkfGlEPTB;NEWuNFI{OyEQvF2= NGflTHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
EW-16 M4m5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\XTWM2OD12Nj6zNVM4KM7:TR?= Ml\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SK-N-AS NXHEe49IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR4LkexOlch|ryP MmLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
COR-L105 NWDPWG9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDFfnZKSzVyPUS2Mlg5PTdizszN NFT4fWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
DEL M3i4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTUPGJKSzVyPUS4MlA1OjlizszN NX\0W45wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
JVM-2 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLYOpk{UUN3ME20PE4xPTV6IN88US=> NGjpUFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
KARPAS-45 NF3IZ|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrFU|lmUUN3ME20PU41PTN6IN88US=> Mme5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
BL21 (DE3) M33zc2Z2dmO2aX;uJIF{e2G7 MlftRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IGSxNFFYKG23dHHueEBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxJEhFTTNrIHPlcIx{KGK7IHHueIFod26rc4SgbY5lfWOnZDDkbZN{d2OrYYTpc44h[XO|YYmsJGtlKD1iMD61JO69VS5? M2TjdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkiwNlcyLz5zOE[4NFI4OTxxYU6=
BL21 (DE3) NGPxWVZHfW6ldHnvckBie3OjeR?= MmO2Rolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IFu5PHchdXW2YX70JIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliYX70ZYdwdmm|dDDpcoR2[2WmIHTpd5Nw[2mjdHnvckBie3OjeTygT4QhRSByLkWg{txONg>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3NUc,OTh4OECyO|E9N2F-
BL21 (DE3) MmrsSpVv[3Srb36gZZN{[Xl? MUDCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JG1ldTJiRkW1W{BufXSjboSg[ZhxemW|c3XkJIlvKEW|Y3jldolkcGmjIHPvcIkhSkx{MTCoSGU{MSClZXzsd{BjgSCQTWKgcIlo[W6mLYDyc5RmcW5iYnnuZZJ6KHSrdILheIlwdixiS3SgQUAxNjVizszNMi=> MofxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|EoRjF6NkiwNlcyRC:jPh?=
SJSA1 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVTZZ3JGOyCmYYnz NHr3UXVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPKV2EyKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDF[HUhcW6lb4Lwc5JifGmxbjDhd5NigSCrbjDwdoV{\W6lZTDv[kAyOCViaIXtZY4he2W{dX2sJGlEPTBiPTCwMlch|ryPLh?= NUfz[WY5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NlQ2OjdpPkKyOVI1PTJ5PD;hQi=>
HCT116 MYXGeY5kfGmxbjDhd5NigQ>? M4mzZ|I1KGi{cx?= M2jWWmlv\HWldHnvckBw\iCyNUOtV4VzOTVicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB{NDDodpMtKEmFNUCgQUAyKM7:TT6= M1fRUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEW2PVIxLz5zOUi1OlkzODxxYU6=
BL21 (DE3) M2Ptc2Z2dmO2aX;uJIF{e2G7 NU\jVFlHSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBz\WOxbXLpcoFvfCCPZH2yJHQyODGZIH31eIFvfCCneIDy[ZN{\WRiaX6gSZNkcGW{aXPobYEh[2:uaTDCUFIyKCiGRUOpJINmdGy|IHL5JG5OWiCuaXfhcoQueHKxdHXpckBjcW6jcomgeIl1emG2aX;uMEBM\CB;IEGg{txONg>? MmCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|EoRjF6NkiwNlcyRC:jPh?=
BL21 (DE3) MmTJSpVv[3Srb36gZZN{[Xl? MmHQRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IFu5PHchdXW2YX70JIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliTl3SJIxq\2GwZD3wdo91\WmwIHLpcoFzgSC2aYTyZZRqd25uIFvkJF0hOSEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3NUc,OTh4OECyO|E9N2F-
SJSA1 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{whUUN3MDC9JFEh|ryPLh?= NFLQPIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5OlMzOCd-MkWzPVY{OjB:L3G+
RKO MXPDfZRwfG:6aXPpeJkh[XO|YYm= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDST28h[2WubIOsJGlEPTBiPTCxJO69VS5? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN7NkOyNEc,OjV|OU[zNlA9N2F-
HCT116 M3XvUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUL1WINVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|LDDJR|UxKD1iMTFOwG0v M2rKRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{m2N|IxLz5{NUO5OlMzODxxYU6=
SJSA1 MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2PJWmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNLW0FzIHPlcIx{KGW6cILld5NqdmdiTVTNNkBjgSCVUlKgZZN{[XluIFfJOVAhRSBzLkOg{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUiwNUc,OjF6N{W4NFE9N2F-
HCT116 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NIfjZ|c4OiCqcoO= NV20W2d3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGVicEWzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEGuN{DPxE1w NX\qXWJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNlE6OzVpPkOwNlIyQTN3PD;hQi=>
HCT116 NEfPNm9HfW6ldHnvckBie3OjeR?= NXHaNZNIQCCqcoO= M3nLVGlv\HWldHnvckBw\iCyNUOgbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGOxZYjwdoV{e2mwZzDwdFU{XEFvbIXjJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEigbJJ{KGK7IH\pdoVndHlxcnXubYxt[SCudXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCLQ{WwJF0hOS5|OTFOwG0v NY\rcGFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4OVY6OjBpPkG5PFU3QTJyPD;hQi=>
HGF M2jsNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYKyOEBpenN? MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIS2Yh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuOEDPxE1w MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-
SJSA1 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYK3NkBpenN? NF;T[VlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPKV2EyKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSBzLkS0JO69VS5? M{PWUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkKxPVM2Lz5|MEKyNVk{PTxxYU6=
SJSA1 Ml\PR5l1d3SxeHnjbZR6KGG|c3H5 M4TBV|Uh\GG7cx?= NFvPSYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUlODMTDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDwOVMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPSEQvF2u MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyME[5OEc,OjR7MEC2PVQ9N2F-
RKO M1;2VmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWK1JIRigXN? MkXCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT61JO69VS5? MmixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC2PVQoRjJ2OUCwOlk1RC:jPh?=
HCT116 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NUTXWI9JPSCmYYnz MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGVicEWzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlUh|ryPLh?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyME[5OEc,OjR7MEC2PVQ9N2F-
A2780 MnvIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mo\VS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRVI4QDBiY3XscJMh\XiycnXzd4lv\yCPRF2yJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDFwNjFOwG0v MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUiwNUc,OjF6N{W4NFE9N2F-
HCT116 MWHDfZRwfG:6aXPpeJkh[XO|YYm= M{O0c|czKGi{cx?= Moi2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9ibIXjbYZmemG|ZT3iZZNm\CCjc4PhfUwhUUN3MDC9JFEvPiEQvF2u NVz5emFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|k5PDVpPkK0NVM6QDR3PD;hQi=>
SJSA1 NIDqN2VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYrUcnFvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{whUUN3MDC9JFEvQSEQvF2u NXjZWoxSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY3PjFpPkK0OlU3PjZzPD;hQi=>
SJSA1 NIO4XmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHvYZ444OiCqcoO= MnfERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSmPBNUBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRz\S2JbH:gZZN{[XluIFnDOVAhRSBzLkmg{txONg>? NGXJNXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzOyd-Mk[5PFU{OjN:L3G+
HCT116 MoDuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjPV5g4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHX4dJJme3OrbnegUWROOiCkeTDTVmIh[XO|YYmsJGdKPTBiPTCyMlEh|ryPLh?= NW\RVIFnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U5ODFpPkKxPFc2QDBzPD;hQi=>
NGP NV7BUWlCS3m2b4TvfIlkcXS7IHHzd4F6 M3qxe|czKGi{cx?= M{\tS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5IWCClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJwMTFOwG0v MlrlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
LS M1;zWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV[3NkBpenN? NGrEU5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNWyClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJwMzFOwG0v NXfKPFRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVQyOjhpPkKxN|E1OTJ6PD;hQi=>
SJSA1 M33sTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHva[XI4OiCqcoO= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJwNjFOwG0v NYDKVXR4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVQyOjhpPkKxN|E1OTJ6PD;hQi=>
MCF7 NHPRdFVEgXSxdH;4bYNqfHliYYPzZZk> NXLLflBiOjRiaILz NYHCPHFpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOi57IN88UU4> M1z2RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
HCT116 NHXvd2lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVG3NkBpenN? NWryNJFbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhcW5icEWzJEgsNytrIHj1cYFvKEiFVEGxOkBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB2IN88UU4> NGPhc4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm4O|YxQCd-Mki5PFc3ODh:L3G+
A549 M3;qeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV23NkBpenN? MnnrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvPjJizszNMi=> M1TXdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCxPFE6Lz5{M{[wNVgyQTxxYU6=
A549 NFSyUZJEgXSxdH;4bYNqfHliYYPzZZk> MmDXO|IhcHK| NEXVdYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIIC1N{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE43OiEQvF2u M2nVbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cxLz5{M{[xNVc4ODxxYU6=
MCF7 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MY[3NkBpenN? MoTIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlAyKM7:TT6= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyMUi5N{c,OjdzMEG4PVM9N2F-
HepG2 NEHUPWpEgXSxdH;4bYNqfHliYYPzZZk> MnGyOFghcHK| MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU4yKM7:TT6= MoryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2N{m3O|AoRjJ3NEe5O|cxRC:jPh?=
HCT116 MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlvKO|IhcHK| MnfFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlIyKM7:TT6= MoXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEG4PVMoRjJ5MUCxPFk{RC:jPh?=
UKF-NB-3 NGDrc4ZEgXSxdH;4bYNqfHliYYPzZZk> NVHFbIFCQTZiaILz MluzR5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IHj1cYFvKFWNRj3ORk0{KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlU3KM7:TT6= MorqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7NEe2NVcoRjJyOUS3OlE4RC:jPh?=
SJSA1 NHfWcnZHfW6ldHnvckBie3OjeR?= NX;WSXp3PyCqcoO= MX3BZ5Rqfmm2eTDheEBxPTNiaX6gbJVu[W5iU1rTRVEh[2WubIOgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIICyNUBuWk6DIHX4dJJme3Orb36gZYZ1\XJiNzDodpMh[nlicWLUMXBEWiCjbnHsfZNqeyCrbjDwdoV{\W6lZTDv[kAyOCViaIXtZY4he2W{dX2sJGlEPTBiPTC3MlEh|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV{NEWyO{c,OjJ3MkS1Nlc9N2F-
HCT116 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWm0PEBpenN? NG\OcHpIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiaHHyZo9zcW6pIIC1N{swMyCjZoTldkA1QCCqcoOgZpkhUG:nY3jzeEA{OzJ3ODDzeIFqdmmwZzDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFfJOVAhRSB6IN88UU4> MkHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyN|AoRjJ7MEi5NlMxRC:jPh?=
MCF7 M2O0b2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWTtXFI6PzJiaILz MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSB6LkWg{txONg>? NYP4PIh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOFU3OjFpPkOwNFQ2PjJzPD;hQi=>
HCT116 NX7rXHllSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWPseohKOjRiaILz MkXWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYheDV|Kz:rJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEK0JIhzeyCkeTDF[HUwUG:nY3jzeEA{OzN2MjDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZY5idHm|aYOsJGdKPTBiPTC5JO69VS5? M{HQbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkmxNVU3Lz5{OU[5NVE2PjxxYU6=
HCT116 MkixRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MX[3NkBpenN? NF\XNWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFkvODdizszNMi=> NHvUXnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC0OVYzOSd-M{CwOFU3OjF:L3G+
A549 MmjJRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWi3NkBpenN? NWPMO5ZwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gPU42QCEQvF2u NYToTJlwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOFU3OjFpPkOwNFQ2PjJzPD;hQi=>
HepG2 NInmcZlEgXSxdH;4bYNqfHliYYPzZZk> NXLaOYp3OjRiaILz NHzNWlhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwMjFOwG0v M1Lu[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
NCI-H1299 M1rocWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1XoPVczKGi{cx?= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIC1N{AuNy1iaIXtZY4hVkOLLVixNlk6KGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEGwMlQh|ryPLh?= NITH[|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKyNVk{PSd-M{CyNlE6OzV:L3G+
MCF7 MV3DfZRwfG:6aXPpeJkh[XO|YYm= MXu0PEBpenN? NWTXZoFLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwNjFOwG0v NX\k[Jg5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NVg2QTVpPkK1OlE5PTl3PD;hQi=>
Saos2 MkLNRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NH;p[mk4OiCqcoO= NHrpVWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIC1N{1l\W[rY3nlcpQhW2Gxc{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{LkGg{txONg>? MorjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7NEC3NFQoRjJ{OUSwO|A1RC:jPh?=
HCT116 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NEXCblk4OiCqcoO= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwOVMh\XiycnXzd4lv\yCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUAyOyEQvF2u NGrwTIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOFEzQCd-MkGzNVQyOjh:L3G+
U2OS MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmLqO|IhcHK| NInYcnNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGWyU3Mh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND6zNUDPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB2NkK0PEc,OjNyNE[yOFg9N2F-
H1299 MWPDfZRwfG:6aXPpeJkh[XO|YYm= MWm3NkBpenN? NVjueJFLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDF{OUmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDseYNq\mW{YYPlMYJie2WmIHHzd4F6NCCLQ{WwJF0hOTRwNzFOwG0v NUjjT|loRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|k5PDVpPkK0NVM6QDR3PD;hQi=>
A549 NYnJSmU5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUPVWYdzPzJiaILz NFnDRmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNTFOwG0v NHjNOlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm0NFcxPCd-MkK5OFA4ODR:L3G+
A549 NXTUcJdzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NF34T4g4OiCqcoO= NHnwV4tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6xNkDPxE1w NGO5fIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C0OlI1QCd-MkOwOFYzPDh:L3G+
U937 MnXlR5l1d3SxeHnjbZR6KGG|c3H5 M3\EfVI1KGi{cx?= NWTZWWVqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTl|NzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTVwNjFOwG0v NXv5TlRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
Saos2 NFzEPYxEgXSxdH;4bYNqfHliYYPzZZk> NGrDNXg4OiCqcoO= NVfnRVRjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCxPEDPxE1w NXT5VlYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVQyOjhpPkKxN|E1OTJ6PD;hQi=>
U2OS NVz6dZhGSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4n3S|czKGi{cx?= NWXqW41SSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNm9UKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUmuOkDPxE1w M3;KZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUSwO|A1Lz5{Mkm0NFcxPDxxYU6=
NCI-H1299 NEO3d2tCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkfSO|IhcHK| NGnzOVVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTJ7OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDF7Lke2JO69VS5? NETWN249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC0OVYzOSd-M{CwOFU3OjF:L3G+
PC3 NHzsNWdEgXSxdH;4bYNqfHliYYPzZZk> MYi3NkBpenN? M37hPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJA2Oy2wdXzsJHBEOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOjBwMESg{txONg>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMUixPUc,OjN4MEG4NVk9N2F-
PC3 Ml\CR5l1d3SxeHnjbZR6KGG|c3H5 M{DnO|czKGi{cx?= NH7oWXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxPTNiZHXmbYNq\W62IGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMkCuNFQh|ryPLh?= NITQeoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OCd-MkO2NVE4PzB:L3G+
A2780/CP70 NUTHZoxQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTFWlhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MD;DVFcxKGOnbHzzJIV5eHKnc4PpcochcXOxZ3XubYNidGy7IIDhbZJm\CCyNUOgcZV1[W62IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFIxNjRizszNMi=> M2O3TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe1PFAyLz5{MUi3OVgxOTxxYU6=
NCI-H1299 NU[5TXgzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmW3O|IhcHK| NITvVppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIC1N{1l\W[rY3nlcpQhVkOLLVixNlk6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE41KM7:TT6= NIOybYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm0NFcxPCd-MkK5OFA4ODR:L3G+
NCI-H1299 MlnERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1O3dlczKGi{cx?= MmPURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDwOVMh\GWoaXPp[Y51KGi3bXHuJG5EUS2KMUK5PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCuOFgh|ryPLh?= NVn1T|dZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOFYzPDhpPkKzNFQ3OjR6PD;hQi=>
HCT116 NYq5c297SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVvJTIQ3PzJiaILz MmfJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyNUOtcpVtdCCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIyNjVizszNMi=> M{DrRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUCxPFk{Lz5{N{GwNVg6OzxxYU6=
SJSA1 M4n1bWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX;3ToZQOjRiaILz MnGzR5l1d3SxeHnjbZR6KGmwIHj1cYFvKFOMU1GxJINmdGy|IH;2[ZIh\XiycnXzd4lv\yCqdX3hckBFVTJiYX\0[ZIhOjRiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFXDOVAhRSB{Mj64JO69VS5? NHrJdIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG1NFA4Pyd-MkmxOVAxPzd:L3G+
C643 M33E[WN6fG:2b4jpZ4l1gSCjc4PhfS=> MXyyOEBpenN? MlnkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR|Y1OyClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMh|ryPLh?= NFfO[Wc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MDA-MB-231 NID3eGFEgXSxdH;4bYNqfHliYYPzZZk> NV;vc4J1PDhiaILz MknCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuOUDPxE1w MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MUi1PVUoRjJ3NkG4OVk2RC:jPh?=
U2OS Mk\TRY51cXS3bX;yJIF{e2G7 NVHNbW5pPzJiaILz NEnNfZJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNm9UKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOlEh|ryPLh?= NUDOPHdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PVY1PjVpPkKxPVk3PDZ3PD;hQi=>
HCT116 NYfQc2dRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVfSXVFKT3Kxd4ToJIlvcGmkaYTpc44hd2ZicEWzJIRm\mmlaXXueEBpfW2jbjDIR3QyOTZiY3XscJMh\XiycnXzd4lv\yCPRF2yJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDJ3Lk[g{txONg>? MmfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W4NFEoRjJzOEe1PFAyRC:jPh?=
HCT116 M1uwRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVvFOY5JPDhiaILz NUHmdJhmT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4heDV|IHvuc4Ns\G:5bjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JGhw\WOqc4SgN|MzPThic4ThbY5qdmdiYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCJSUWwJF0hOjdizszNMi=> MmHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyN|AoRjJ7MEi5NlMxRC:jPh?=
Calu Ml3iR5l1d3SxeHnjbZR6KGG|c3H5 Mnn3NlQhcHK| M4npbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNidHViY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4NjJizszNMi=> NIPYeGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
HCT116 Mnn1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NInwdpkzPCCqcoO= Mmf3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYheDV|LT:tJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEK0JIhzeyCkeTDF[HUwUG:nY3jzeEA{OzN2MjDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZY5idHm|aYOsJGdKPTBiPTCyPUDPxE1w NH32S|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[5NVE2Pid-Mkm2PVEyPTZ:L3G+
MDA-MB-435S M2[zN2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWC0T3cyPzJiaILz M{HVbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTR|NWOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlYh|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzFyMUi5N{c,OjdzMEG4PVM9N2F-
PC3 NUHvNVc2S3m2b4TvfIlkcXS7IHHzd4F6 NYTodWdROjRiaILz NUD5dFY4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OC5|IN88UU4> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-
Saos2 MonTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYX3blJXPzJiaILz MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIC1N{Bl\W[rY3nlcpQhcHWvYX6gV4FwezJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMyNjZ{IN88UU4> M4W5PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MES2NlQ5Lz5{M{C0OlI1QDxxYU6=
HCT116 MnvLRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYO0PEBpenN? NELzSI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IEOyMlEyKM7:TT6= NIizW4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1NlI4PSd-MkS4OVIzPzV:L3G+
HCT116 NU[4O2pUS3m2b4TvfIlkcXS7IHHzd4F6 MV[3NkBpenN? NUnzPWhmS3m2b4TvfIlkcXS7IHHnZYlve3RicEWzJIRm\mmlaXXueEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSB|NDFOwG0v MoPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
HCT116 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{PYZ|I1KGi{cx?= MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDlfJBz\XO|aX7nJJA2OyCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOzlwNkWg{txONg>? MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{Nki3PVUoRjJ2Mk[4O|k2RC:jPh?=
A549 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmfaOFghcHK| Ml7kRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVAhRSB2Nz61PUDPxE1w M{\ESlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEWyNlc2Lz5{NEi1NlI4PTxxYU6=
HCT116 M4naOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoL0O|IhcHK| M17Xb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIlvKHB3MzCoMU8uMSCqdX3hckBJS1RzMU[gZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hPDdwODFOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl6N{[wPEc,Ojh7OEe2NFg9N2F-
MCF7 MnXjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnfWOFghcHK| NEn3W3dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IES4Mlc1KM7:TT6= MnvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NUKyO|UoRjJ2OEWyNlc2RC:jPh?=
SJSA1 MVnGeY5kfGmxbjDhd5NigQ>? M1jQOFExKHWP MlTqTY5pcWKrdHnvckBw\iCPRF2yMZA2OyCrboTldoFkfGmxbjDpckBpfW2jbjDTTnNCOSClZXzsd{Bie3Onc4Pl[EBieyCyNUOgZYN1cX[jdHnvckBifCBzMDD1UUBjgSCZZYP0[ZJvKGKub4S= M4G4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUK4PVIzLz5zOUmyPFkzOjxxYU6=
MCF7 MVPD[YxtKGO7Y3zlJIF{e2G7 MUK0JJVO Mo\kNVQh\GG7cx?= MXHJcoR2[3Srb36gc4Yh[2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUOINzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHB3Mz30ZZJo\XSrbnegbXJPSS2kYYPl[EB{cFKQQTDheEA1KHWPIHHmeIVzKDF2IHThfZMh[nliQoLkWUBqdmOxcoDvdoF1cW:wIHHzd4F6 NGXhUlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS3OFM5OSd-MU[0O|Q{QDF:L3G+
MCF7 MlLkR4VtdCCleXPs[UBie3OjeR?= NEnaRVk1KHWP MYqxOEBl[Xm| M3;afGlv\HWldHnvckBw\iClZXzsJIN6[2ynIHHydoV{fCCrbjDoeY1idiCPQ1[3JINmdGy|IITyZY5{\mWldHXkJIhvWk6SSz30ZZJo\XSrbnegbXJPSS2kYYPl[EB{cFKQQTDheEA1KHWPIHHmeIVzKDF2IHThfZMh[nliQoLkWUBqdmOxcoDvdoF1cW:wIHHzd4F6 M2LXNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEe0N|gyLz5zNkS3OFM5OTxxYU6=
MCF7 NFrZblJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIfQNFc1KHWP MV2xOEBl[Xm| NF71NHhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZQhPCC3TTDh[pRmeiBzNDDkZZl{KGK7IHPvc41ie3OrZTDzeIFqdmmwZx?= MnPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2N{SzPFEoRjF4NEe0N|gyRC:jPh?=
MCF7 NHm4Z4VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHLoTHI1KHWP NXfL[ZVMOTRiZHH5dy=> NXfUT3Y3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGGycHXhdoFv[2Vib3[g[oxifHSnbnXkJJBp\W6xdInw[UBifCB2IIXNJIFnfGW{IEG0JIRigXNiYomgZ49wdWG|c3nlJJN1[WmwaX7n NF3kTnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS3OFM5OSd-MU[0O|Q{QDF:L3G+
MCF7 NVTvVpBlTnWwY4Tpc44h[XO|YYm= MnLXTY5lfWO2aX;uJI9nKHB3MzDlfJBz\XO|aX;uJIlvKGi3bXHuJG1ETjdiY3XscJMhfHKjboPm[YN1\WRid3n0bEA2O0KSMT30ZZJo\XSrbnegbXJPSS2kYYPl[EB{cFKQQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? Mm\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2N{SzPFEoRjF4NEe0N|gyRC:jPh?=
MCF7 NIXvVnRHfW6ldHnvckBie3OjeR?= NH7yR2xKdmS3Y4Tpc44hd2ZicEWzJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUOINzDj[YxteyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> M4rUVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEe0N|gyLz5zNkS3OFM5OTxxYU6=
MCF7 NGHBZVhHfW6ldHnvckBie3OjeR?= NIO2VoEyQCCqcoO= NGLFR|VKdmS3Y4Tpc44hd2ZicEWzJIFk[3WvdXzheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDF6IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYOgbY4heHKnc3XuZ4Uhd2ZiMj61JI1OKGOjZn\lbY5m NIDxNlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS3OFM5OSd-MU[0O|Q{QDF:L3G+
BJ M1;hOGZ2dmO2aX;uJIF{e2G7 M1zJdFMhfU1? M1HCTmlv\HWldHnvckBw\iCyMkHDTXAyKGW6cILld5Nqd25iaX6gbZJz[WSrYYTl[EBpfW2jbjDCTkBk\WyuczDheEA{KHWPIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M2XIT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEe0N|gyLz5zNkS3OFM5OTxxYU6=
MCF7 NEDnUm9E\WyuIHP5Z4xmKGG|c3H5 M4[5eVQhfU1? MlHKNVQh\GG7cx?= NUDOZplHUW6mdXP0bY9vKG:oIHPlcIwh[3mlbHWgZZJz\XO2IHnuJIh2dWGwIF3DSlch[2WubIOgeJJidnOoZXP0[YQhf2m2aDC1N2JROS22YYLn[ZRqdmdiaWLORU1j[XOnZDDzbHJPSSCjdDC0JJVOKGGodHXyJFE1KGSjeYOgZpkhSnKmVTDpcoNwenCxcnH0bY9vKGG|c3H5 NXXiN2dORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0O|Q{QDFpPkG2OFc1OzhzPD;hQi=>
BJ NEPzPGFHfW6ldHnvckBie3OjeR?= NFLCfIg{KHWP MXHJcoR2[3Srb36gc4YheDJzIHX4dJJme3Orb36gbY4hcXK{YXTpZZRm\CCqdX3hckBDUiClZXzsd{BifCB|IIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NFnpO5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS3OFM5OSd-MU[0O|Q{QDF:L3G+
SNJSA1 NI\wdHJHfW6ldHnvckBie3OjeR?= MWKxJJRwKDFyIIXN MV62JIhzew>? NW\6fXZvUW6qaXLpeIlwdiCxZjDN[I0zKC2yNUOgdJJwfGWrbjDpcpRmemGldHnvckBqdiCqdX3hckBUVkqVQUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKHB{MTDwdo91\WmwIHH0JFEhfG9iMUCgeW0h[W[2ZYKgOkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MorRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
SNJSA1 NU\5elBkTnWwY4Tpc44h[XO|YYm= MYSxJJRwKDFyIIXN MkSxOkBpenN? MYrJcohq[mm2aX;uJI9nKE2mbUKgMZA2OyCycn;0[YlvKGmwdHXyZYN1cW:wIHnuJIh2dWGwIGPOTnNCOSClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gdFU{KHC{b4TlbY4h[XRiMTD0c{AyOCC3TTDh[pRmeiB4IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NHvvXG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOFEzQCd-MkGzNVQyOjh:L3G+
SNJSA1 NHHGOGJHfW6ldHnvckBie3OjeR?= MVGxJJRwKDFyIIXN NYXtRYp2PiCqcoO= MVzJcohq[mm2aX;uJI9nKE2mbUKgMZA2OyCycn;0[YlvKGmwdHXyZYN1cW:wIHnuJIh2dWGwIGPOTnNCOSClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gUWROOiCycn;0[YlvKGG2IEGgeI8hOTBidV2gZYZ1\XJiNjDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NGXtWFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOFEzQCd-MkGzNVQyOjh:L3G+
MCF7 NV[yRVNWTnWwY4Tpc44h[XO|YYm= Mlj5NlQhcHK| MV;VdJJm\3WuYYTpc44hd2ZicEWzJIlvKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NF7PNVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNFUxOid-MkewNVA2ODJ:L3G+
MCF7 Mn\ISpVv[3Srb36gZZN{[Xl? M{j2blI1KGi{cx?= Mo\ZWZBz\We3bHH0bY9vKG:oIF3kcVIhcW5iaIXtZY4hVUOINzDj[YxteyCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMEWwNkc,OjdyMUC1NFI9N2F-
MCF7 MYHGeY5kfGmxbjDhd5NigQ>? MnzUNlQhcHK| MkL5TY5kemWjc3WgbY4heDV|IHX4dJJme3Orb36gbY4hcHWvYX6gUWNHPyClZXzsd{BvfWOuZXmgZYZ1\XJiMkSgbJJ{KGK7IFTBVGkhe3SjaX7pcoch[mG|ZXSgbY1ufW6xZnz1c5Jme2OnbnPlJI1q[3Kxc3PvdJk> NWfjNlU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVA2ODJpPkK3NFExPTB{PD;hQi=>
MCF7 NVfTV5d3TnWwY4Tpc44h[XO|YYm= M3jHWVI1KGi{cx?= M37sNnVxemWpdXzheIlwdiCxZjDwNlEhcW5iaIXtZY4hVUOINzDj[YxteyCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MljEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUC1NFIoRjJ5MEGwOVAzRC:jPh?=
HCT116 M3\HV2Z2dmO2aX;uJIF{e2G7 MofxOVAhfU1? M4fPZVI1KGi{cx?= MmnWTY5pcWKrdHnvckBw\iCyNUOtUWROOiBqdX7rco94diCxcnnnbY4qKGmwdHXyZYN1cW:wIHX4dJJme3OnZDDpckBxPTNvZHXmbYNq\W62IHj1cYFvKEiFVEGxOkBk\WyuczDheEA2OCC3TTDh[pRmeiB{NDDodpMh[nliQnnGR{1j[XOnZDDGRWNUKG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=> M4f6PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mk[4O|k2Lz5{NEK2PFc6PTxxYU6=
U2OS M2rKVmZ2dmO2aX;uJIF{e2G7 M{PrdlIvPSC3TR?= MoXkNVIhcHK| NX63cpk4W3SjYnnsbZpifGmxbjDv[kBxPTNiaX6gbJVu[W5iVULPV{Bk\WyuczDhd5Nme3OnZDDhd{BqdnS{YXPlcIx2dGG{IIC1N{Bt\X[nbDDheEAzNjVidV2gZYZ1\XJiMUKgbJJ{KGK7IGfld5Rmem5iYnzveJRqdmd? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ6OE[4OEc,OjZ{OEi2PFQ9N2F-
HCT116 MYnGeY5kfGmxbjDhd5NigQ>? MlfTNVAhfU1? NHHlSYczOCCqcoO= Mn\OTY5pcWKrdHnvckBw\iCYMT3wOVMwVUSPMj3WNkApfW6tbn;3ckBwemmpaX6pJIlvfGW{YXP0bY9vKGW6cILld5Nm\CCrbjDoeY1idiCKQ2SxNVYheDV|LT:tJINmdGy|IHH0JFExKHWPIHHmeIVzKDJyIHjyd{BjgSCkaX;tc4xm[3WuYYKg[ox2d3Knc3PlcoNmKGOxbYDs[Y1mdnSjdHnvck1j[XOnZDDmcI94KGO7dH;t[ZRzcWNiYX7hcJl{cXN? NYrZTHp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4NFA1PTVpPkK4PFAxPDV3PD;hQi=>
IMR32 MlK4SpVv[3Srb36gZZN{[Xl? M2S0S|I1KGi{cx?= NIm2c3dKdmO{ZXHz[UBqdiCyNUOg[ZhxemW|c3nvckBqdiCqdX3hckBKVVJ|MjDj[YxteyCwdXPs[Ykh[W[2ZYKgNlQhcHK|IHL5JGRCWElic4ThbY5qdmdiYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl? M4\4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGwOVAzLz5{N{CxNFUxOjxxYU6=
MCF7 NEDDWpVHfW6ldHnvckBie3OjeR?= MkPHNVAhfU1? MmH3NVYhcHK| NV;U[5ZWUW6qaXLpeIlwdiCxZjDNSG0zNXB3MzDpcpRmemGldHnvckBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILleoVze2GuIH;mJG1FVTJvZHXw[Y5l\W62IHnubIljcXSrb36gc4YheDV|LXnu[JVk\WRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGG2IEGwJJVOKGGodHXyJFE3KGi{czDifUBlfWGuLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> MmDUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NEC5N|QoRjJ|NUSwPVM1RC:jPh?=
MCF7 NWLDOZlGSXCxcITvd4l{KGG|c3H5 MX2zJJVO NFniRYczPCC2bzC3NkBpenN? NX2xOHg5UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDCZ4wugExiZYjwdoV{e2mxbjDs[ZZmdCCjdDCzJJVOKGGodHXyJFI1KHSxIEeyJIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6pIHHuZYx6e2m| M1rxWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 NWCxeoVZSXCxcITvd4l{KGG|c3H5 NHfZXnE{KHWP Mm\INlQhfG9iN{KgbJJ{ Mnf5TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIViemy7IHHwc5B1d3SrYzDj[YxteyCjdDCzJJVOKGGodHXyJFI1KHSxIEeyJIhzeyCkeTDhco5mgGmwIG[tSmlVSy:ycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oKGKjc3XkJGZCS1NiZnzve{BkgXSxbXX0dpkhMFK4YjC9JFQhLSl? NULKdW1qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
MCF7 MkPKRZBweHSxc3nzJIF{e2G7 NWnY[Ic{OyC3TR?= Mn7MNlQhfG9iN{KgbJJ{ NIDkXW5KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icEKxJIV5eHKnc4Ppc44hdGW4ZXygZZQhOyC3TTDh[pRmeiB{NDD0c{A4OiCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> M3rR[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 NHrrNHpCeG:ydH;zbZMh[XO|YYm= MlizN{B2VQ>? MWKyOEB1dyB5MjDodpM> M2PZXGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCEY3ytfHMh\XiycnXzd4lwdiCuZY\lcEBifCB|IIXNJIFnfGW{IEK0JJRwKDd{IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ NF75cXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 NHzHcJNCeG:ydH;zbZMh[XO|YYm= MXG1NEBvVQ>? NWTDOXVpOjRidH:gO|IhcHK| MXvJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKG:oIHPhd5Bie2VvMzDjcIVifmGpZTDwdo9lfWO2IHH0JFUxKG6PIHHmeIVzKDJ2IITvJFczKGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz NH7sNIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 NHPDNG5E\WyuIHP5Z4xmKGG|c3H5 NWrFNlBrOyC3TR?= M3ixSlI1KHSxIEeyJIhzew>? MYXD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOC:JMTDwbIF{\SCjdDCzJJVOKGGodHXyJFI1KHSxIEeyJIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKE[DQ2OgZY5idHm|aYO= MkHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MEK3NVYoRjJ|OECyO|E3RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / MDM2 / p21 / Bax / Bak / Noxa / cleaved caspase / pro-caspase; 

PubMed: 16014563     


Expression of apoptosis- and cell-cycle–associated proteins in OCI-AML-3 cells, which were treated with 5 μM Nutlin-3a for the indicated times. Nutlin-3a induced increased protein expression of p53, MDM2, and p21 in OCI-AML-3 cells in a time-dependent fashion. Nutlin-3a induced Noxa, a BH3-only member of the Bcl-2 family, followed by caspase activation. β-actin was used to confirm equal loading of proteins. Arrowheads indicate cleared caspases.

BMI-1; 

PubMed: 26887044     


Western blot analysis of BMI-1 and actin was performed in BV-173, SUP-B15, NALM-6, NALM-19 and REH cell lines after 24 hours treatment with increasing concentrations of Nutlin-3a (1 μM, 2 μM, 5 μM) and with DMSO control. 

p53-Ser15 / p53-Ser37 / p53-Lys382 / MDM2 / CDC2 / PLK1 / HSC70; 

PubMed: 23666059     


Expression of the indicated proteins in whole-cell lysates of cells treated for 96 h with 50 μM resveratrol (R), 5 μM nutlin-3a (N), or co-treated with both substances (RN).

16014563 26887044 23666059
Immunofluorescence
p-p21 / β-actin; 

PubMed: 31083332     


Cells were treated with fluoride (5 mM) with/without Nutlin-3a for 24 h. p-p21 (green), nucleus (DAPI; blue) and β-actin (red) expression were detected by immunocytochemistry. Nutlin-3a addition augmented p-p21 expression compared to NaF treatment alone.

P53; 

PubMed: 21394100     


At 12 h following treatment with nutlin-3a, DoHH2 and MCA cells had increased levels of p53 visualized by immunofluorescence. p53 localization was predominantly nuclear. The 4',6-diamidino-2-phenylindole was used as counterstain of the nuclei.

Ac-p300; 

PubMed: 30240745     


HepG2 cells were treated with 5 μM Nutlin-3a for 24 hr, and the levels of Ac-p300 and p53 were assessed by co-immunofluorescence. Fluorescence intensity of Ac-p300 in control cells versus Nutlin-3a-treated cells have been quantified (represented as mean ± SD, unpaired two-tailed Student's t test, n = 50 of three independent experiments). Scale bar, 10 μm.

31083332 21394100 30240745
Growth inhibition assay
Cell viability; 

PubMed: 26248031     


All 15 cell lines were plated in 96-well plates. After 24h, media was exchanged and cells were treated with incremental concentrations of Nutlin-3a (1 μM, 5 μM, 10 μM, 25 μM, 50 μM, and 70 μM). After 72h of Nutlin-3a treatment, cell viability was measured by WST assay and compared to untreated control.

26248031
In vivo Nutlin-3a suppresses xenograft growth in a dose-dependent fashion with the highest dose (200 mg/kg) showing a substantial tumor shrinkage [1]. Nutlin-3 is a selective activator of the p53 pathway in vivo and highly efficacious against SJSA-1 osteosarcoma tumors[1]. Tumors with wild-type p53 and mdm2 gene amplification will respond best to therapy with Nutlin-3a.

Protocol

Kinase Assay:[3]
- Collapse

Biacore studies:

Competition assays are performed on a Biacore S51. A Series S Sensor chip CM5 is derivatized for immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~ 200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Test compounds are dissolved in DMSO at 10 mM and further diluted to make a concentration series of inhibitor in each MDM2 test sample. The assays are run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of inhibitor is calculated as a percentage of binding in the absence of inhibitor and IC50 is calculated using Microsoft Excel
Cell Research:[2]
- Collapse
  • Cell lines: OSA, T778, RMS13, U2OS, SaOS-2
  • Concentrations: ~5 μM
  • Incubation Time: 120 h
  • Method: SRB
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: SJSA-1 xenograft
  • Dosages: 50, 100, 200 mg/kg twice daily
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (171.97 mM)
Water Insoluble
Ethanol '100 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 581.49
Formula

C30H30Cl2N4O4

CAS No. 675576-98-4
Storage powder
in solvent
Synonyms (-)-Nutlin-3
Smiles CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is the difference between S1061 (Nutlin-3) and S8059 (Nutlin-3a)?

  • Answer:

    S1061 is a racemic mixture of Nutlin3a and Nutlin3b. s8059 is the active enantiomer of Nutlin3.

Mdm2 Signaling Pathway Map

Related Mdm2 Products

Tags: buy Nutlin-3a | Nutlin-3a supplier | purchase Nutlin-3a | Nutlin-3a cost | Nutlin-3a manufacturer | order Nutlin-3a | Nutlin-3a distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID