Vincristine (NSC-67574) sulfate

Catalog No.S1241 Synonyms: Leurocristine, Oncovin, 22-Oxovincaleukoblastine

For research use only.

Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.

Vincristine (NSC-67574) sulfate Chemical Structure

CAS No. 2068-78-2

Selleck's Vincristine (NSC-67574) sulfate has been cited by 91 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2.2.15 NX;a[JB[S2WubDDWbYFjcWyrdImgRZN{[Xl? M3jNOlAuOC53IN88US=> M1eyOlI1KGh? M2PDUoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 Mm\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NkO3OlkoRjJ3Nk[zO|Y6RC:jPh?=
HepG2-HBV1.1 M2SyUGFxd3C2b4Ppd{BCe3OjeR?= MmjwNE0xNjVizszN M2TsPFI1KGh? MU\pcoR2[2W|IHHwc5B1d3OrczDkc5NmKGSncHXu[IVvfGy7 MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4M{e2PUc,OjV4NkO3Olk9N2F-
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CNS MlnzR5l1d3SxeHnjbZR6KGG|c3H5 NGHVclQ1QCCqcoO= NW\NVmtTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS06VIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkGzJO69VS5? NXTOUVZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
Melanoma cells M1nRVmFvfGm2dX3vdkBie3OjeR?= MYC0PEBpenN? M3;Q[WFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3lcIFvd22jIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjF3OES5JO69VS5? NV7vb4RkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Melanoma cells NY\ZVlBCS3m2b4TvfIlkcXS7IHHzd4F6 NFW1fm5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBu\Wyjbn;tZUBk\WyuczygS2k2OCB;IECuNVU5PDlizszNMi=> MkDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
Melanoma cells MY\BcpRqfHWvb4KgZZN{[Xl? MV3BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDt[Yxidm:vYTDj[YxteyxiR1m1NEA:KDBwMUW4OFkh|ryPLh?= NVj0W3ppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
Melanoma cells Ml32RY51cXS3bX;yJIF{e2G7 MWS0PEBpenN? NWT2b5J6SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUYVt[W6xbXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1mgQUAxNjF4IN88UU4> Ml3QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
Melanoma cells MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYKwRW1pT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdWWuYX7vcYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zNjFOwG0v M1XYTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
Melanoma cells NFjtUXBEgXSxdH;4bYNqfHliYYPzZZk> NIrnVJU1QCCqcoO= MlH5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcYVt[W6xbXGgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4yPiEQvF2u NV25U3JWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
Melanoma cells NWLsZ5ozS3m2b4TvfIlkcXS7IHHzd4F6 MXG0PEBpenN? M{flXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whT0l3MDC9JFAvOTZizszNMi=> MoK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
A549 NGKzflBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIH6WFY1QCCqcoO= NVztNW9tSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE4OTVizszNMi=> MmftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
NSCLC MlvqRY51cXS3bX;yJIF{e2G7 NIPlV4E1QCCqcoO= M3PPTmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7TR2xEKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKKD1iMD6yOUDPxE1w M4DaWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
NSCLC MkH1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWe0PEBpenN? NVrOVll4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVlOFTFOgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4zPSEQvF2u MoDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
NSCLC M1;PdWN6fG:2b4jpZ4l1gSCjc4PhfS=> MV60PEBpenN? NVjJSHlQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVlOFTFOgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4zPSEQvF2u NVXEWphWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
NSCLC NFjzTo1EgXSxdH;4bYNqfHliYYPzZZk> MWO0PEBpenN? MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkK1JO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
NSCLC M4XxbWFvfGm2dX3vdkBie3OjeR?= NVLwbFdoSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhVlOFTFOgZ4VtdHNuIFfJOVAhRSByLkK1NVE6KM7:TT6= NWLnTXh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
NSCLC Mo\pRY51cXS3bX;yJIF{e2G7 NHPidpM1QCCqcoO= Ml7URY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTmPDUGMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNlUyOTlizszNMi=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Non-small cell lung carcinoma cells NXPuXYVuS3m2b4TvfIlkcXS7IHHzd4F6 MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOc44ue22jbHygZ4VtdCCudX7nJINiemOrbn;tZUBk\WyuczygS2k2OCB;IECuNlUyOTlizszNMi=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
ovarian cancer cells NHnNZpNEgXSxdH;4bYNqfHliYYPzZZk> Ml7HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gc5ZiemmjbjDjZY5k\XJiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? NXjmWHkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
renal cancer cells Mni3R5l1d3SxeHnjbZR6KGG|c3H5 NYexclVNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{NCCJSUWwJF0hOC5|MU[yN{DPxE1w M{Pjd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
breast cancer cells NEfqfJBEgXSxdH;4bYNqfHliYYPzZZk> NX3SdWZOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyxiR1m1NEA:KDBwM{G2NlMh|ryPLh?= NV\wPW9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
ovarian cancer cells MofqRY51cXS3bX;yJIF{e2G7 NHPF[GI1QCCqcoO= Mm[1RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5ib4\hdolidiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuN|E3OjNizszNMi=> M2DweFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
renal cancer cells NXTSNppuSW62aYT1cY9zKGG|c3H5 MYK0PEBpenN? Mn;GRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icnXuZYwh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkOxOlI{KM7:TT6= Mn6xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
breast cancer cells NWjuZ3FOSW62aYT1cY9zKGG|c3H5 MV[0PEBpenN? NIThPZJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCdoVie3RiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlMyPjJ|IN88UU4> NIjRPHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells M2HxeGFvfGm2dX3vdkBie3OjeR?= NHPBfmxCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBz\W6jbDD0eY1weiClZXzsd{whT0l3MDC9JFAvOzF4MkOg{txONg>? M3qxc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
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NSCLC NVrMPI1TSW62aYT1cY9zKGG|c3H5 Mn7pRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgUnNEVENiY3XscJMtKFSJSTC9JFE2Njh2OEmg{txONg>? MoDhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUmyNFUoRjF5NUW5NlA2RC:jPh?=
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Leukemia cells M{S2eWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyxiVFfJJF0hOTVwOES4PUDPxE1w NUHhOmsxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
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NSCLC NG[0PZVEgXSxdH;4bYNqfHliYYPzZZk> Mn\lOFghcHK| MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF3Lki1JO69VS5? M2THcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFMxLz5{MkK4N|Q{ODxxYU6=
Leukemia cells Mk\uR5l1d3SxeHnjbZR6KGG|c3H5 MV60PEBpenN? MnPMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzMEBVT0liPTCxOU45PSEQvF2u MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
NSCLC MXvDfZRwfG:6aXPpeJkh[XO|YYm= MV20PEBpenN? M1;LN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NEe3OFkoRjJ2N{S3O|Q6RC:jPh?=
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renal cancer cells M125c2FvfGm2dX3vdkBie3OjeR?= NUPBdpFYPDhiaILz MXnBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiC{ZX7hcEBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiVFfJJF0hOTlwOUWyOkDPxE1w M2rveFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
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ovarian tumor cells Mmr3RY51cXS3bX;yJIF{e2G7 MnP0RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sgc5ZiemmjbjD0eY1weiClZXzsd{whXEeLIE2gNVkvQTV{NjFOwG0v NVG0fY92RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
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neural precursor cells MoTlSpVv[3Srb36gZZN{[Xl? NGWzXpRKdmirYnn0bY9vKG:oIH7leZJwe3CqZYLlJJBzd2yrZnXyZZRqd25ib3[gcY92e2VibnX1doFtKHC{ZXP1dpNweiClZXzsd{BjgSCPVGSgZZN{[Xl? NHX4U5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxO|Y{OSd-MUe0NVc3OzF:L3G+
Assay
Methods Test Index PMID
Western blot MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1 26156322
Growth inhibition assay Cell viability 26156322
In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol (from reference)

Cell Research:[1]
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
  • (Only for Reference)
Animal Research:[6]
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(108.33 mM)
Water 60 mg/mL
(65.0 mM)
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448834 Suspended Drug: Blinatumomab B-cell Acute Lymphoblastic Leukemia Dorothy Sipkins MD PhD|Amgen|Acrotech Biopharma LLC|Duke University May 24 2021 Phase 2
NCT03981510 Recruiting Diagnostic Test: 3D-Transit Constipation|Childhood Acute Lymphoblastic Leukemia|Neurofibromatosis 1|Chronic Constipation With Overflow University of Aarhus June 13 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

Answer:
According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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