Vincristine (NSC-67574) sulfate

For research use only.

Catalog No.S1241 Synonyms: Leurocristine, Oncovin, 22-Oxovincaleukoblastine

83 publications

Vincristine (NSC-67574) sulfate Chemical Structure

CAS No. 2068-78-2

Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.

Selleck's Vincristine (NSC-67574) sulfate has been cited by 83 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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K562 NIHKb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\FSolKSzVyPUCuNFMzKMLzIECuNFAyKCEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|NUmzO{c,OjRzM{W5N|c9N2F-
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K562 M2r2eGFxd3C2b4Ppd{BCe3OjeR?= NU\1OnNCOC5|IN88US=> Mnm4NlQhcA>? M13Neolv\HWlZYOgZZBweHSxc3nzJJNq\26rZnnjZY51dHl? M3H5XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUO1PVM4Lz5{NEGzOVk{PzxxYU6=
K562/ADR M13QOmFxd3C2b4Ppd{BCe3OjeR?= MoPLN{DPxE1? MlHTNlQhcA>? M{fZeYlv\HWlZYOgZZBweHSxc3nz NHLS[3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzOVk{Pyd-MkSxN|U6Ozd:L3G+
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Jurkat NYTNNZR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PmdVXDqM7:Zz;tcOKh MWKyOEBp M4TFdIFzemW|dDDKeZJs[XRiY3XscJMhcW5iR{KvUUBxcGG|ZR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMESwPUc,OjN6MUC0NFk9N2F-
Hep-2 NGnmd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jpXmlEPTB;MD6wOOKyOC5yMTFOwG0> NG\Gb409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4NFQzPCd-MkO3PFA1OjR:L3G+
Hep-2/v M3HUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDwTWM2OD1zLklCtVAvOjBizszN MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OEC0NlQoRjJ|N{iwOFI1RC:jPh?=
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KB-3-1 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XWc2lEPTB;MT6yOkDDuSByLkCyO{DPxE1? NHLpUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[3N|Q1PSd-MkO2O|M1PDV:L3G+
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A549/EGFP  MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX6wMlAyNTFyMECg{txO Mm\0TWM2OD16Nj63JOKyKDJ7LkGg{txO NV:4[llbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2N|QzQDJpPkKzOlM1Ojh{PD;hQi=>
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prostate cancer cells M{O2cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWS0PEBpenN? NHLuXndIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4yOyEQvF2u NWfReZhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
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Melanoma cells Mmm1RY51cXS3bX;yJIF{e2G7 MonDOFghcHK| NUPnSoRDSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUYVt[W6xbXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMUW4OFkh|ryPLh?= MnKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
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Melanoma cells M2\1Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDt[Yxidm:vYTDj[YxteyCjZoTldkA1QCCqcoOsJGdKPTBiPTCwMlE3KM7:TT6= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
Melanoma cells NWq4XGdnS3m2b4TvfIlkcXS7IHHzd4F6 NXzseWlZPDhiaILz NFrCR5pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBu\Wyjbn;tZUBk\WyuczDh[pRmeiB2ODDodpMtKEeLNUCgQUAxNjF4IN88UU4> NWrJWHpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
Melanoma cells NWHxZ4E3S3m2b4TvfIlkcXS7IHHzd4F6 NWHYU4M3PDhiaILz MmHLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcYVt[W6xbXGgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4yPiEQvF2u MmriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
A549 NGn4bXlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NF34d|k1QCCqcoO= M3:4PWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xO|E2KM7:TT6= MkPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
NSCLC NULDVGM5SW62aYT1cY9zKGG|c3H5 M{DlXlQ5KGi{cx?= MoDKRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTmPDUGMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2khRSByLkK1JO69VS5? M1;JU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
NSCLC MnXBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\xXmk1QCCqcoO= MX\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkK1JO69VS5? NUnpV25XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
NSCLC NX\he4p4S3m2b4TvfIlkcXS7IHHzd4F6 NXq5dlRmPDhiaILz M2PZUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygS2k2OCB;IECuNlUh|ryPLh?= NXPlfHNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
NSCLC MoPKR5l1d3SxeHnjbZR6KGG|c3H5 NFzBO3g1QCCqcoO= NHvJVmFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPW0OOQzDj[YxteyCjZoTldkA1QCCqcoOsJGdKPTBiPTCwMlI2KM7:TT6= NWfaeoRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
NSCLC NXHPRY1MSW62aYT1cY9zKGG|c3H5 MV3BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDOV2NNSyClZXzsd{whT0l3MDC9JFAvOjVzMUmg{txONg>? NEC5RW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
NSCLC NWfOVHRYSW62aYT1cY9zKGG|c3H5 M2G4[|Q5KGi{cx?= NUDRboRHSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvOjVzMUmg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Non-small cell lung carcinoma cells MoPHR5l1d3SxeHnjbZR6KGG|c3H5 NWjZWodJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVm:wLYPtZYxtKGOnbHygcJVv\yClYYLjbY5wdWFiY3XscJMtKEeLNUCgQUAxNjJ3MUG5JO69VS5? Moj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
ovarian cancer cells NY\ZXWxvS3m2b4TvfIlkcXS7IHHzd4F6 MmnTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gc5ZiemmjbjDjZY5k\XJiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? MluxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
renal cancer cells MnfER5l1d3SxeHnjbZR6KGG|c3H5 NYHjSm5RS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{NCCJSUWwJF0hOC5|MU[yN{DPxE1w NV3v[Y5kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
breast cancer cells MV\DfZRwfG:6aXPpeJkh[XO|YYm= NV7oUWpJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyxiR1m1NEA:KDBwM{G2NlMh|ryPLh?= M3rCOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
ovarian cancer cells MYrBcpRqfHWvb4KgZZN{[Xl? MVe0PEBpenN? MUDBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCxdnHybYFvKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6zNVYzOyEQvF2u Mo\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
renal cancer cells NH3LV4JCdnSrdIXtc5Ih[XO|YYm= NYHDTYxmPDhiaILz MoLTRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icnXuZYwh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkOxOlI{KM7:TT6= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
breast cancer cells MnXiRY51cXS3bX;yJIF{e2G7 NXzTcmdQPDhiaILz NFvIZotCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCdoVie3RiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlMyPjJ|IN88UU4> NEXTOFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells NV23ZYhxSW62aYT1cY9zKGG|c3H5 M1Oxc2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JJJmdmGuIIT1cY9zKGOnbHzzMEBIUTVyIE2gNE4{OTZ{MzFOwG0v NFXvdoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
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Melanoma cells M374RmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1rqeFQ5KGi{cx?= M13M[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gO{46PCEQvF2u MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
breast cancer cells NELkUXlEgXSxdH;4bYNqfHliYYPzZZk> MXy0PEBpenN? M2fEVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSB5Lkm0JO69VS5? M33rOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFMxLz5{MkK4N|Q{ODxxYU6=
Melanoma cells NVzSUYdtSW62aYT1cY9zKGG|c3H5 MoHVOFghcHK| MYDBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPZXzhco9u[SClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTC3Mlk1OzJ6IN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Melanoma cells MlPGR5l1d3SxeHnjbZR6KGG|c3H5 M2rCcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|LDDUS2khRSB5Lkm0N|I5KM7:TT6= M{PpbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
breast cancer cells M{[yUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGq2W5JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{NCCWR1mgQUA4Njl2M{K4JO69VS5? NU[5c3lZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
breast cancer cells MlLpRY51cXS3bX;yJIF{e2G7 MYq0PEBpenN? M3THW2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLy[YF{fCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygWGdKKD1iNz65OFMzQCEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Melanoma cells NFXEeHBCdnSrdIXtc5Ih[XO|YYm= MXTBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDt[Yxidm:vYTDj[YxteyxiVFfJJF0hPy57NEOyPEDPxE1w MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3OUKwOUc,OTd3NUmyNFU9N2F-
breast tumor cells NFi1cW1CdnSrdIXtc5Ih[XO|YYm= MX;BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDidoVie3RidIXtc5Ih[2WubIOsJHRIUSB;IEeuPVQ{OjhizszNMi=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3OUKwOUc,OTd3NUmyNFU9N2F-
NSCLC Mki1RY51cXS3bX;yJIF{e2G7 M3e2XWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JG5US0yFIHPlcIx{NCCWR1mgQUAyPS56NEi5JO69VS5? NFPOVlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
Leukemia cells M2nyNmFvfGm2dX3vdkBie3OjeR?= M4POVVQ5KGi{cx?= MmnIRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTHX1b4VucWFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhXEeLIE2gNVUvQDR6OTFOwG0v M{H1clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
NSCLC MnziRY51cXS3bX;yJIF{e2G7 M1zPXlQ5KGi{cx?= M2HIcWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7TR2xEKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJHRIUSB;IEG1Mlg1QDlizszNMi=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Non-small cell lung carcinoma cells NVjKW3pXS3m2b4TvfIlkcXS7IHHzd4F6 M4PMPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5wdi2|bXHscEBk\WyuIHz1coch[2G{Y3nuc41iKGOnbHzzMEBVT0liPTCxOU45PDh7IN88UU4> NUTQSWdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
Leukemia cells NVXTdFlFS3m2b4TvfIlkcXS7IHHzd4F6 NX3QSo5FS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOsJHRIUSB;IEG1Mlg1QDlizszNMi=> Mk\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
Leukemia cells NFvT[VZCdnSrdIXtc5Ih[XO|YYm= NUHlPVdySW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdGW3a3XtbYEh[2WubIOsJHRIUSB;IEG1Mlg1QDlizszNMi=> MkfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUmyNFUoRjF5NUW5NlA2RC:jPh?=
NSCLC NHHvclhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVm0PEBpenN? MUHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF3Lki1JO69VS5? MoDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
Leukemia cells NF7UdppIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;iSWQ1QCCqcoO= NF7tRYVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMtKFSJSTC9JFE2Njh3IN88UU4> MmGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
NSCLC M2\6b2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXG0PEBpenN? MnPiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzNT64OUDPxE1w MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
Leukemia cells MnTFR5l1d3SxeHnjbZR6KGG|c3H5 M2DLdFQ5KGi{cx?= MoTjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzMEBVT0liPTCxOU45PSEQvF2u MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
NSCLC NHe2UmpEgXSxdH;4bYNqfHliYYPzZZk> NFvYT3U1QCCqcoO= M1;XcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= M1q5OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
Leukemia cells M3TkXGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkXBOFghcHK| M1;PPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gNVUvQDVizszNMi=> NEL1[WU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q{OCd-MkKyPFM1OzB:L3G+
renal cancer cells NGL0e4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEn4XpQ1QCCqcoO= MkXQS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyxiVFfJJF0hOTlwOUWg{txONg>? M1;rZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
ovarian cancer cells NGfGdlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MY[0PEBpenN? M1zZfWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG93[XKrYX6gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUmuPVUh|ryPLh?= MkfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
renal cancer cells NE\yNY1EgXSxdH;4bYNqfHliYYPzZZk> MX[0PEBpenN? MmCwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyxiVFfJJF0hOTlwOUWg{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
ovarian cancer cells MlPKR5l1d3SxeHnjbZR6KGG|c3H5 MWe0PEBpenN? NF;KU5pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEG5Mlk2KM7:TT6= NFG1W4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0O|c1QSd-MkS3OFc4PDl:L3G+
renal cancer cells NGnzbnZEgXSxdH;4bYNqfHliYYPzZZk> M1uxeVQ5KGi{cx?= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyQS57NTFOwG0v MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
ovarian cancer cells Mn;sR5l1d3SxeHnjbZR6KGG|c3H5 NXLzWohRPDhiaILz Mof0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gc5ZiemmjbjDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzOT65OUDPxE1w MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
ovarian cancer cells Mmn2R5l1d3SxeHnjbZR6KGG|c3H5 MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDveoFzcWGwIHPhcoNmeiClZXzsd{whXEeLIE2gNVkvQTV{NjFOwG0v NH7lVWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
renal cancer cells MlHFR5l1d3SxeHnjbZR6KGG|c3H5 M{PORWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{whXEeLIE2gNVkvQTV{NjFOwG0v NELXeWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
ovarian cancer cells MWrBcpRqfHWvb4KgZZN{[Xl? NIi5eGg1QCCqcoO= Moi1RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5ib4\hdolidiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygWGdKKD1iMUmuPVUzPiEQvF2u NHTiXmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells MlPVRY51cXS3bX;yJIF{e2G7 MVu0PEBpenN? MXLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiC{ZX7hcEBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiVFfJJF0hOTlwOUWyOkDPxE1w NFTGWYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal tumor cells MYTBcpRqfHWvb4KgZZN{[Xl? M{PC[GFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JJJmdmGuIIT1cY9zKGOnbHzzMEBVT0liPTCxPU46PTJ4IN88UU4> M1;KNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
ovarian tumor cells MWrBcpRqfHWvb4KgZZN{[Xl? M1TqOmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI93[XKrYX6geJVud3JiY3XscJMtKFSJSTC9JFE6Njl3Mk[g{txONg>? NYXuPIN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
PC3 Ml3pR5l1d3SxeHnjbZR6KGG|c3H5 NHvQNXo1QCCqcoO= NH[4VmpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkiuNVEh|ryPLh?= M1HjS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUe0PFE3Lz5{OUG3OFgyPjxxYU6=
neural precursor cells M1LUTmZ2dmO2aX;uJIF{e2G7 NV7iNHhWUW6qaXLpeIlwdiCxZjDu[ZVzd3OyaHXy[UBxem:uaX\ldoF1cW:wIH;mJI1wfXOnIH7leZJidCCycnXjeZJ{d3JiY3XscJMh[nliTWTUJIF{e2G7 MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1; 

PubMed: 26156322     


MOLT-4 Cells were treated with vincristine (0.3, 1, and 3 nM) alone or co-treated with SAHA (500 nM) for 24 h. Then, total cell lysates were obtained to evaluate the G2/M phase regulatory protein expression and the tubulin acetylation. Data are expressed as mean values ± SD of at least three separate determinations. S SAHA, V vincristine

26156322
Growth inhibition assay
Cell viability ; 

PubMed: 26156322     


MOLT-4 cells were treated with various concentrations of vincristine for 24 and 48 h, respectively.  Cell viability was measured by MTT assay.

26156322
In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
in solvent
Synonyms Leurocristine, Oncovin, 22-Oxovincaleukoblastine
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448834 Not yet recruiting Drug: Blinatumomab B-cell Acute Lymphoblastic Leukemia David Rizzieri MD|Amgen|Acrotech Biopharma LLC|Duke University April 1 2021 Phase 2
NCT03981510 Recruiting Diagnostic Test: 3D-Transit Constipation|Childhood Acute Lymphoblastic Leukemia|Neurofibromatosis 1|Chronic Constipation With Overflow University of Aarhus June 13 2019 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • Answer:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID