Vincristine sulfate

Catalog No.S1241 Synonyms: Leurocristine

Molecular Weight(MW): 923.04

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

Cited by 34 Publications

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Elife, 2019, 8

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J Lipid Res, 2019, 60(6):1078-1086

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Biochem Pharmacol, 2019, 170:113642

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Oncotarget, 2019, 10(60):6403-6417

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J Exp Med, 2018, 215(8):2137-2155

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Clin Cancer Res, 2018, 10.1158/1078-0432.CCR-18-1965

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Cell Death Dis, 2017, 8(10):e3062

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J Pharmacol Exp Ther, 2017, 363(1):20-34

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Int J Oncol, 2017, 51(1):257-268

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Drugs R D, 2017, 17(2):287-296

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Cell Death & Disease, 2017, 10.1038/cddis.2017.454

PubMed: ( click the link to review the publication )

Drug Des Devel Ther, 2017, 11:1335-1351

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BMC Pharmacol Toxicol, 2017, 18(1):63

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ACS Cent Sci, 2016, 2(8):545-59

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Lipids Health Dis, 2016, 15:152

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Mol Cancer Res, 2016, 14(10):909-919

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Cell Rep, 2015, 13(11):2353-2361

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J Pharmacol Exp Ther, 2014, 350(3):646-56

PubMed: 24993360 ( click the link to review the publication )

Cancer Res, 2013, 73(20):6310-22

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Int J Mol Sci, 2012, 13(9):10736-49

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Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

Targets

Microtubules ^[1]
(Cell-free assay)

32 μM

In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with K_i of 85 nM. ^[1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. ^[2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. ^[4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. ^[5]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
HepG2.2.15	NV\Sc5VYS2WubDDWbYFjcWyrdImgRZN{[Xl?	M3f5WFAuOC53IN88US=>	MXuyOEBp		M2XEUoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7	NF:3Z4MzPTZ4M{e2PS=>
HepG2-HBV1.1	MVzBdI9xfG:\|aYOgRZN{[Xl?	MXiwMVAvPSEQvF2=	NEHmVpAzPCCq		NUS5enZZcW6mdXPld{BieG:ydH;zbZMh\G:\|ZTDk[ZBmdmSnboTsfS=>	M17kPFI2PjZ\|N{[5
HepG2.2.15	M1LVVmZ2dmO2aX;uJGF{e2G7	M{D5ZlAvOSEQvF2=	NFixSJUzPCCq		NYW2RnBHeHKxbX;0[ZMhcGWyYYTpeIl{KEJidnnyeZMheHKxdHXpckBmgHC{ZYPzbY9v	MmXYNlU3PjN5Nkm=
HepG2-HBV1.1	MVnGeY5kfGmxbjDBd5NigQ>?	NIf2fFgxNjFizszN	Ml\3NlQhcA>?		MV3wdo9ud3SnczDo[ZBifGm2aYOgRkB3cXK3czDwdo91\WmwIHX4dJJme3Orb36=	M3zyTlI2PjZ\|N{[5
HepG2-HBV1.1	MYPGeY5kfGmxbjDBd5NigQ>?	NGrvZXUxNjFizszN	MWS0PEBp		NG[ye\|Zxem:vb4Tld{Bk\WyuIHX4Z5JmfGmxbjDv[kBp\XCjdHn0bZMhSiC4aYL1d{BvfWOuZX;jZZB{cWS\|IHnud5Rm[WRib3[gbIVx[XSrdHnzJGIhfmm{dYOgSIFv\SCyYYL0bYNt\XN?	NX3Xd5VoOjV4NkO3Olk>
HepG2-HBV1.1	MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4fjclAvOSEQvF2=	MYSxMVUh\A>?		M2n2cIlvcGmkaYTzJJRp\SCycn;sbYZmemG2aX;uJJRqdWViZHXw[Y5l\W62bIm=	NVzydIJtOjV4NkO3Olk>
HepG2-HBV1.1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2jwNlAvOSEQvF2=	MVuxMVUh\A>?		NXTMSopwcW6qaXLpeJMhfGinIIDyc4xq\mW{YYTpc44hfGmvZTDk[ZBmdmSnboTsfS=>	NIj1e\|czPTZ4M{e2PS=>
HepG2-HBV1.1	M13ySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUjQPHQzOC5zIN88US=>	M1rJUVEzNTd{IHi=		Ml7ubY5lfWOnczDj[YxtKGO7Y3zlJIFzemW\|dDDheEBUNXCqYYPl	NGPSd5ozPTZ4M{e2PS=>
HepG2-HBV1.1	NFnYeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LCWlAvOSEQvF2=	NWrjdpY1OTJvN{KgbC=>		MnnpbY5lfWOnczDj[YxtKGO7Y3zlJIFzemW\|dDDheEBUNXCqYYPl	M3rkZ\|I2PjZ\|N{[5
Raji	NVnRdWRYTnWwY4Tpc44hSXO\|YYm=	Ml7DNE42yqEQvF2=	MkPaO\|IhcA>?		M4\pToFjd2yrc3jld{BifXSxcHjh[5nDqA>?	MmTBNlU1PDZ\|N{e=
SK-MEL-28	M3HEfWZ2dmO2aX;uJGF{e2G7	M3PwVlMxKG6P	NFrTNVk3KGh?		NF2xZplqdmS3Y3XzJGcz6oDVTTDj[YxtNWO7Y3zlJIFzemW\|dB?=	M3PTblI2OzF\|MEGw
H157	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUOyW\|NkUUN3ME2xMlA{KMLzIECuNFQhdWm3Ml2=	NXHj[2RHOjV{NUe5NVE>
Jurkat	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYSxMVMhdk1?	MlfOOFjDqGh?	NVPJTpV3TE2VTx?=	M2OyToRm[3KnYYPld{B3cWGkbHWgZ4VtdCCwdX3i[ZJ{KGSxc3Wg[IVx\W6mZX70cJk>	MVuyOVE2PjF2Nh?=
CEM	MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TDW\|EuOyCwTR?=	Ml:zOFjDqGh?	MUfEUXNQ	NVm5fGFo\GWlcnXhd4V{KH[rYXLs[UBk\WyuIH71cYJmenNiZH;z[UBl\XCnbnTlcpRtgQ>?	MVuyOVE2PjF2Nh?=
P12	M2D3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLUVIFqOS1\|IH7N	MYm0POKhcA>?	M2\jbmROW09?	NELCS3ll\WO{ZXHz[ZMhfmmjYnzlJINmdGxiboXtZoVzeyCmb4PlJIRmeGWwZHXueIx6	MUWyOVE2PjF2Nh?=
KB	NInQWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4DmPWlEPTB;MD6wNFQ6KMLzIECuNFAxOSEQvF2=	NHK4bVYzPTB3OEWyOi=>
KBv200 (ABCB1)	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MofKTWM2OD1yLkO0OlIhyrFiMD6wNFY3KM7:TR?=	MoPpNlUxPTh3Mk[=
SUDHL6	Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVmx5qCK\|ryP	NVGzTpQ4PDhxN{KgbC=>		M1zUZolvcGmkaYTzJINmdGxidnnhZoltcXS7IIPp[45q\mmlYX70cJk>	MV2yOFk3OTZyNB?=
SUDHL6	MkTySpVv[3Srb36gRZN{[Xl?	NGrEO2Qy6oDLzszN	MlP4O\|IhcA>?		NULFSYdZcW6mdXPld{B{cWewaX\pZ4FvfCCjcH;weI91cWNibX;ydIhwdG:peTDjbIFv\2W\|IHPveJJme3SnZDD3bZRpKEKFTEGxRUB{cVKQQR?=	MX2yOFk3OTZyNB?=
HCT-116	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4rYZ2dKPTB;NTDuUS=>	NULuWJBmOjR7Mke4OVc>
SKNBe2C	NIftUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NE\Nb29KSzVyPUOyMljDuTRwMDDuUS=>	MonXNlQ6OjF7MkC=
IGNR91	NETB[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkXtTWM2OD1{ND6zxtEyNjdibl2=	MVGyOFkzOTl{MB?=
SKNAS	NXH1fXNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXS3VVRGUUN3ME2xMlXDuTBwMjDuUS=>	NVXvOpRqOjR7MkG5NlA>
LAN1	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmX5TWM2OD1{LkRCtVAvOiCwTR?=	NVXTXIFROjR7MkG5NlA>
SHSY5Y	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRThwMtMxNE43KG6P	NFH5UnYzPDl{MUmyNC=>
A549-WT	M13hRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTF7LkSzO{DDuSByLkW5OEAhdk1?	MXeyOFg2QDh{Nx?=
A549-R	MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTF{LkG3PEDDuSByLkOzN{Ahdk1?	M{D2NVI1QDV6OEK3
MCF-7-WT	NHjZ[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPlfFNEUUN3ME2xO{44PTJiwsGgNE4zOThiIH7N	NVXLTmJJOjR6NUi4Nlc>
MCF-7-R	MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVrJR\|UxRTVwNUO5JOKyKDBwMUS0JEBvVQ>?	MX[yOFg2QDh{Nx?=
A549-R	NVjiVmN1S3m2b4TvfIlkcXS7IFHzd4F6				NVX5S5BDUUN3ME2xNk4yPzhiwsGgNE4{OzNibl2=	MX6yOFg2QDh{Nx?=
MCF-7-R	MUjDfZRwfG:6aXPpeJkhSXO\|YYm=				MX;JR\|UxRTVwNUO5JOKyKDBwMUS0JI5O	NHvQfIUzPDh3OEiyOy=>
SW620	MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVi2NFJuUUN3ME23MlgxKMLzIECuNFghdk1?	NUPOR4J3OjR5Mk[3N\|k>
SW620/AD300	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYfJR\|UxRTlyOT62NEDDuSB6LkmxJI5O	MUCyOFczPjd\|OR?=
HEK293/pcDNA3.1	M3Hv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mo\ETWM2OD1zLkS1JOKyKDBwMkCgcm0>	NEXKUHUzPDd{NkezPS=>
HEK293/ABCC1	MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX\JR\|UxRTF7LkK5JOKyKDJwMEigcm0>	MkXBNlQ4OjZ5M{m=
TCC	MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUPFVohEOjRiaB?=		NE\BSZNKSzVyPUewJI5O	M{XXPFI1PzF4OUS0
TCC	MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NXPIdVkzPDhiaB?=		MojFTWM2OD13MDDuUS=>	NGSz[m4zPDdzNkm0OC=>
HepG2/ADM	M2PKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXTJR\|UxRTJwN{i2N:KyOC5{M{exJO69VQ>?	MVeyOFcxPDV3Nh?=
HepG2	NXTaZpoyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn[wTWM2OD1yLkCxNVXDuTBwMECxO{DPxE1?	NULMPHFkOjR5MES1OVY>
MCF-7/ADR	NVLYOHRsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEP6Z4VKSzVyPUSuOFgzPsLzMD6yNFcxKM7:TR?=	MkXUNlQ4ODR3NU[=
MCF-7	NGnzcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mm\STWM2OD1yLkCxOVnDuTBwMEC2NkDPxE1?	NED3W4MzPDdyNEW1Oi=>
A-172	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGLDTncxNjIEoN88US=>	NWO3PIh2OjRxN{KgbC=>		M{HVZolvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk>	MWKyOFU{ODJ\|NR?=
U-251MG	M4fMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXmwMlHDqM7:TR?=	MoTkNlQwPzJiaB?=		M4D2SIlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk>	M2nF[\|I1PTNyMkO1
DLD-1	MXzGeY5kfGmxbjDBd5NigQ>?	MlPyNVAxKG6P	M{fabFQ5KGh?		MWLwdo9ud3SnczDSWW5ZOyCmZX3leIh6dGG2aX;uxsA>	Ml:zNlQ1ODN2NUO=
CCD18Co	NV\pR2J5TnWwY4Tpc44hSXO\|YYm=	M1\acVExOCCwTR?=	M1zLeVQ5KGh?		NXfidnNNeHKxbX;0[ZMhWlWQWEOg[IVu\XSqeXzheIlwdsLi	NFe4eFczPDRyM{S1Ny=>
DLD-1	MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3HWWFAuOTByMDDuUS=>	NV\vOZlxPDhiaB?=		NWPTPGtQcW6qaXLpeJMh[2WubDDndo94fGhiZH;z[UBl\XCnbnTlcpRtgQ>?	M4T5dlI1PDB\|NEWz
CCD18Co	MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnNe5kxNTFyMECgcm0>	MkiyOFghcA>?		MV3pcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5	NHnuZW8zPDRyM{S1Ny=>
HepG2	NWXYfmQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnHvNlQhcA>?		MoOxTWM2OD13Mj615qCK\|ryP	M2rLZVI1OzRzNki4
HEK293/pcDNA3.1	M3TCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYPnTXJrUUN3ME2wMlAxPMLzMD6wNFA{KM7:TR?=	NWDUZ4lOOjR{OES3PFM>
HEK293/MRP1	Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoWyTWM2OD1yLkC1OeKyOC5yMUKwJO69VQ>?	MU[yOFI5PDd6Mx?=
Ramos	NF7MU3FCeG:ydH;zbZMhSXO\|YYm=	MorFNwKBkc7:TR?=	Mm\OOFghcA>?		MUTpcoR2[2W\|IEO0MlYmyrFzLkmyKUBieG:ydH;zbZM>	M13jZ\|I1OjV4NEmx
NCI-H1299/pcDNA3	Ml3JR4VtdCCYaXHibYxqfHliQYPzZZk>	Mmn3NE0zOCCwTR?=	NVLoZlRjQTZiaB?=		M3XO[olvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl?	NGXSN2UzPDF5N{CxNi=>
H1299/ICAM-3	MXHD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NE\mVosxNTJyIH7N	M1SyXlk3KGh?		NHrBXWJqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7	M4K5Z\|I1OTd5MEGy
NCI-H1299/pcDNA3	NG[3W3JHfW6ldHnvckBCe3OjeR?=	NGT6OnMyNzVxMUCvNlDDqG6P	MVO5OkBp		MlvtbY5lfWOnczDjcIVifmGpZTDv[kBk[XOyYYPld{0{NCB6LDC5MEBidmRiUFHSVC=>	MmLNNlQyPzdyMUK=
H1299/ICAM-3	NGDiT3VHfW6ldHnvckBCe3OjeR?=	NF:zO4oyNzVxMUCvNlDDqG6P	Ml3nPVYhcA>?		NXv1cnI5cW6mdXPld{BkdGWjdnHn[UBw\iClYYPwZZNmey1\|LDC4MEA6NCCjbnSgVGFTWA>?	MVqyOFE4PzBzMh?=
W1	Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1LlXWlEPTB;MD6wNFMzKM7:TR?=	M2LYZlI1OTRyMUe2
W1VR	M1nvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUfxT\|BsUUN3ME2wMlA2PiEQvF2=	MnfpNlQyPDBzN{[=
K562	NHv5dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFHyS\|lKSzVyPUCuNFMzKMLzIECuNFAyKCEQvF2=	M4LifFI1OTN3OUO3
K562/ADR	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVWxcVFiUUN3ME2zMlI3OSEEsTCwMlQyOiEQvF2=	NHzTSYIzPDF\|NUmzOy=>
K562	MnjtRZBweHSxc3nzJGF{e2G7	M1XRXVAvOyEQvF2=	MWmyOEBp		NYHmUGZEcW6mdXPld{BieG:ydH;zbZMhe2mpbnnmbYNidnSueR?=	NFzO[HIzPDF\|NUmzOy=>
K562/ADR	Ml7kRZBweHSxc3nzJGF{e2G7	NHrsOZk{KM7:TR?=	MlHHNlQhcA>?		MlHBbY5lfWOnczDhdI9xfG:\|aYO=	NXP4dGhwOjRzM{W5N\|c>
A549	NWLxRmZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFTvcJpKSzVyPUCuNVAhyrFiMD6wN{DPxE1?	MXOyN\|k4OTB5NR?=
K562	NYXHOGpvS2WubDDWbYFjcWyrdImgRZN{[Xl?	MXizMlc26oDVNkFCpI5O	M{jB[\|czyqCqwrC=		NES4UW9qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7	NXnuUHpuOjN6N{eyNlM>
lucena	MkTVR4VtdCCYaXHibYxqfHliQYPzZZk>	MmDTN{44PeLCk{[wxsBvVQ>?	MYi3NuKhcMLi		NFvRe4RvdyCnZn\lZ5Q>	MYqyN\|g4PzJ{Mx?=
FEPS	NVn3NlZHS2WubDDWbYFjcWyrdImgRZN{[Xl?	Moi0N{44PeLCk{[wxsBvVQ>?	NYXHcFRSPzMEoHlCpC=>		NXHDZWM{dm9iZX\m[YN1	MkfJNlM5Pzd{MkO=
A2780	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHzkSpBKSzVyPUOuOUBuVQ>?	NUK0cVFGOjN6MkmyNFM>
ACHN	M3q5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHHURWhKSzVyPECuNUBuVQ>?	NHnPbmUzOzh{OUKwNy=>
U-937	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRDN2IH7N	MoDYNlM5Ojl{MEO=
Jurkat	M3LTR2Fxd3C2b4Ppd{BCe3OjeR?=	Mlj0OeKh\|rypL33sxsA>	M4nFVFI1KGh?		Mnu3bY5lfWOnczDhdI9xfG:\|aYOgd4lodmmoaXPhcpRtgQ>?	NH\SUIszOzhzMESwPS=>
Jurkat	M{HTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7iSVViPcLizsznM41tyqB?	MkG2NlQhcA>?		NXTqSpRs[XK{ZYP0JGp2emujdDDj[YxteyCrbjDHNk9OKHCqYYPl	NF7mbGszOzhzMESwPS=>
Hep-2	MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1nIUWlEPTB;MD6wOOKyOC5yMTFOwG0>	NEPUR4MzOzd6MESyOC=>
Hep-2/v	NFrQNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHLrXWpKSzVyPUGuPOKyOC5{MDFOwG0>	NWjPepllOjN5OEC0NlQ>
SGC-7901	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWOwMVExKM7:Zz;tcC=>	MXKyOE81QC95MjDo		NX24Um9icW6qaXLpeJMh[2WubDDndo94fGhiaX6g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnRibXHucoVz	MXGyN\|c1OzV5Mh?=
SGC-7901/VCR	NGrzOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4K4U\|AuOTBizsznM41t	MWiyOE81QC95MjDo		MlHSbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy	M3j5VFI{PzR\|NUey
SGC-7901	MUXBdI9xfG:\|aYOgRZN{[Xl?				NXXidJZ2cW6mdXPld{BieG:ydH;zbZMhe2mpbnnmbYNidnSueR?=	MoO2NlM4PDN3N{K=
SGC-7901/VCR	MVfBdI9xfG:\|aYOgRZN{[Xl?				NFHCRoFqdmS3Y3XzJIFxd3C2b4Ppd{B{cWewaX\pZ4FvfGy7	MYiyN\|c1OzV5Mh?=
KB-3-1	NYO0[GdKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlPOTWM2OD1zLk[2JOKyKDBwMU[yJO69VQ>?	MWKyN\|Y4OzR2NR?=
KB-C2	M361PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Moe1TWM2OD1{MEKuOVYhyrFiNEKuOFgyKM7:TR?=	NVnU[YxFOjN4N{O0OFU>
KB-3-1	MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIG2cXJKSzVyPUGuNlYhyrFiMD6wNlch\|ryP	M1zF[VI{Pjd\|NES1
KB-V1	NIDWSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4TsUGlEPTB;MkC4Mlg2KMLzIEKwMlQh\|ryP	M2Dkc\|I{Pjd\|NES1
HEK293/pcDNA3.1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Moj1TWM2OD1{ND6xJOKyKDBwMkC0JO69VQ>?	M3i4NlI{Pjd\|NES1
HEK293/ABCB1	MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV7JR\|UxRTN3MUKuPEDDuSB\|N{iuN\|kyKM7:TR?=	MXSyN\|Y4OzR2NR?=
A549/EGFP	M1\Ec2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorLNE4xOS1zMECwJO69VQ>?			M4nnPWlEPTB;OE[uO{DDuSB{OT6xJO69VQ>?	M{mzfFI{PjN2Mkiy
A549/Slug	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWOwMlAyNTFyMECg{txO			M3\3e2lEPTB;OT63JOKyKDNwMTFOwG0>	NXXLSohFOjN4M{SyPFI>
JFCR39	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW[xJOK2VQ>?	NF3L[HIzPCCq	M3XrW2ROW09?	NH\odHlu[XKtZXTsfUBqdmO{ZXHz[ZMhfGinIH71cYJmeiCxZjDHNk9OKHCqYYPlJINmdGy\|	MmjPNlM2QTh{N{[=
A549	MljySpVv[3Srb36gRZN{[Xl?	MoLsNVAxKG6P	NYD0WXljOTZiaB?=	MmTqSG1UVw>?	MlnGcIVi\HNidH:gZUBtd3O\|IH;mJI1q[3KxdIXieYxmew>?	NXH1N5FCOjN3OUiyO\|Y>
SGC7901	M2PIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4DuW2lEPTB;MT6yOwKBkcLz4pEJNE4yOSEQvHevcYw>	NEnBfIMzOzV4NES4Ni=>
SGC7901/LV-NC	M1TDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnXoTWM2OD1zLke35qCKyrIkgJmwMlE3KM7:Zz;tcC=>	MV2yN\|U3PDR6Mh?=
SGC7901/LV-SGO1	M{XvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWezWZlwUUN3ME20MlM36oDLwsJihKkxNjN5IN88[{9udA>?	NX\oOVNzOjN3NkS0PFI>
SGC7901/VCR	M{\GO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUjENYFJUUN3M{2yNE42O+LCidMx5qCKOS57NjFOwIcwdWx?	NU\GVHV7OjN3NkS0PFI>
SGC7901/VCR-NC	M2TuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTF7Lki25qCKyrIkgJmyMlAyKM7:Zz;tcC=>	MkDKNlM2PjR2OEK=
SGC7901/VCR-si-SGO1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkTBTWM2OD14LkG45qCKyrIkgJmxMlA{KM7:Zz;tcC=>	NUTzWGVUOjN3NkS0PFI>
SGC7901/ADR	M3X4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NISwN4lKSzVyPUeuPFXjiIoEsfMAjVAvPjRizsznM41t	NX7CeIVvOjN3NkS0PFI>
SGC7901/ADR-NC	MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYDLephzUUN3ME24Mlk{6oDLwsJihKkxNjZ6IN88[{9udA>?	MV6yN\|U3PDR6Mh?=
SGC7901/ADR-si-SGO1	NHPDd\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYTJR\|UxRTNwNEdihKnDueLCiUCuNlkh\|rypL33s	M4LDR\|I{PTZ2NEiy
SH-SY5Y	M1v1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVjuOGExOC5yMEGtNVAh\|ryP	M3Pl[\|I1KGh?		NEe2OGFKSzVyPUCuNVE{yrFyLkCxNkDPxE1?	MkDLNlMyOjlyNkW=
SH-SY5Y	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjHNE4xODFvMUCg{txO	MlnzOFghcA>?		M2HTV2lEPTB;MD6wO\|jDuTBwMEC5JO69VQ>?	NWLXeo9LOjNzMkmwOlU>
SH-SY5Y	M{XHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXSwMlAxOS1zMDFOwG0>	NE\HPVA4OiCq		MW\JR\|UxRTBwMEWxxtExNjByODFOwG0>	Ml3xNlMyOjlyNkW=
SH-SY5Y	NHXIRYlCeG:ydH;zbZMhSXO\|YYm=	NF;PW2ExNjFizszN	M1fNeFAuOjRiaB?=		NYXseWo1cW6mdXPld{BieG:ydH;zbZMhd2ZiU1itV3k2YSClZXzsd{Bnd2yub4fpcoch[2WubDDjfYNt\SCjcoLld5Qh[XRidHjlJGczN01icHjhd4U>	Moq0NlMyOjlyNkW=
SH-SY5Y	NV\tWJFwSXCxcITvd4l{KEG\|c3H5	M4n0dFAvOSEQvF2=	M1;Rb\|AuOjRiaB?=		NIGw[otqdmS3Y3XzJI1qfG:2aXOgZZJz\XO2wrC=	MV[yN\|EzQTB4NR?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1; PubMed: 26156322 J Hematol Oncol MOLT-4 Cells were treated with vincristine (0.3, 1, and 3 nM) alone or co-treated with SAHA (500 nM) for 24 h. Then, total cell lysates were obtained to evaluate the G2/M phase regulatory protein expression and the tubulin acetylation. Data are expressed as mean values ± SD of at least three separate determinations. S SAHA, V vincristine	26156322
Growth inhibition assay	Cell viability ; PubMed: 26156322 J Hematol Oncol MOLT-4 cells were treated with various concentrations of vincristine for 24 and 48 h, respectively. Cell viability was measured by MTT assay.	26156322

In vivo

Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. ^[6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . ^[7]

Protocol

Cell Research:^[1]	- Collapse Cell lines: B16 melanoma cell Concentrations: 10 nM Incubation Time: 3 days Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 10⁴ cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO₂ and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA. (Only for Reference)
Animal Research:^[6]	- Collapse Animal Models: Human rhabdomyosarcoma xenografts Rh12 Formulation: Water solutioin Dosages: 3 mg/kg Administration: A single i.p. administration (Only for Reference)

Cell Research:^[1]

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Cell lines: B16 melanoma cell
Concentrations: 10 nM
Incubation Time: 3 days
Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 10⁴ cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO₂ and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
(Only for Reference)

Animal Research:^[6]

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Animal Models: Human rhabdomyosarcoma xenografts Rh12
Formulation: Water solutioin
Dosages: 3 mg/kg
Administration: A single i.p. administration
(Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	100 mg/mL (108.33 mM)
	Water	60 mg/mL (65.0 mM)
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): Saline For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Vincristine sulfate SDF

Molecular Weight	923.04
Formula	C₄₆H₅₈N₄O₁₄S
CAS No.	2068-78-2
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	Leurocristine

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03981510	Recruiting	Diagnostic Test: 3D-Transit	Constipation\|Childhood Acute Lymphoblastic Leukemia\|Neurofibromatosis 1\|Chronic Constipation With Overflow	University of Aarhus	June 2019	Not Applicable

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?
Answer:
According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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Vincristine sulfate

Cited by 34 Publications

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References

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Chemical Information Download Vincristine sulfate SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

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Molecular Weight Calculator

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

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Microtubule Associated Signaling Pathway Map

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Vincristine sulfate

Cited by 34 Publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Vincristine sulfate SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-10-14)

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Frequently Asked Questions

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)