Vincristine sulfate

For research use only.

Catalog No.S1241 Synonyms: Leurocristine

73 publications

Vincristine sulfate Chemical Structure

CAS No. 2068-78-2

Vincristine sulfate (Leurocristine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.

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Selleck's Vincristine sulfate has been cited by 73 publications

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Biological Activity

Description Vincristine sulfate (Leurocristine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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CNS NETxOHVCdnSrdIXtc5Ih[XO|YYm= MX:0PEBpenN? NUHvdpBkSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR25UKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6xNlU5QSEQvF2u NVHLc25{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
prostate cancer cells M1T4cmFvfGm2dX3vdkBie3OjeR?= NF3iNZQ1QCCqcoO= M3O5cWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIDyc5N1[XSnIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4yOjV6OTFOwG0v NH7s[4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
CNS MWnBcpRqfHWvb4KgZZN{[Xl? NEPxZ4xCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBEVlNidIXtc5Ih[2WubIOsJGdKPTBiPTCwMlEzPTh7IN88UU4> NXftUmVVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
prostate cancer cells MnnORY51cXS3bX;yJIF{e2G7 NYH6dZFjSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QheHKxc4TheIUhfHWvb4KgZ4VtdHNuIFfJOVAhRSByLkGyOVg6KM7:TT6= NWLETpZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
CNS M1;uPWFvfGm2dX3vdkBie3OjeR?= MX20PEBpenN? MkTNRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ17TJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSTC9JFAvOTNizszNMi=> M1zX[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
prostate cancer cells NIrwO|BCdnSrdIXtc5Ih[XO|YYm= M1jNclQ5KGi{cx?= NHvTXZhCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0liPTCwMlE{KM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
prostate cancer cells NFuz[5lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVTiZokzPDhiaILz NWj3eIpnT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4heHKxc4TheIUh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{whT0l3MDC9JFAvOTNizszNMi=> NGXHN|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OFU6QSd-MkC2PFQ2QTl:L3G+
CNS MmKzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFP6cZM1QCCqcoO= NXvBVWNIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS06VIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkGzJO69VS5? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
CNS MnzlR5l1d3SxeHnjbZR6KGG|c3H5 NVnDe29IPDhiaILz M{j6WmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPWyClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zMzFOwG0v M2\CbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
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prostate cancer cells NHT1U2JEgXSxdH;4bYNqfHliYYPzZZk> NHXD[GU1QCCqcoO= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMD6xN{DPxE1w M1nqfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFMxLz5{MkK4N|Q{ODxxYU6=
CNS NWrC[mpPS3m2b4TvfIlkcXS7IHHzd4F6 MkixOFghcHK| M37CPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPWyClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zMzFOwG0v NXfOfY5uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
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Melanoma cells MUHDfZRwfG:6aXPpeJkh[XO|YYm= M3Tre2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|LDDHTVUxKD1iMD6xOVg1QSEQvF2u MnzqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
Melanoma cells MU\BcpRqfHWvb4KgZZN{[Xl? MorXRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcYVt[W6xbXGgZ4VtdHNuIFfJOVAhRSByLkG1PFQ6KM7:TT6= NWTZN|NtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
Melanoma cells M1OydWFvfGm2dX3vdkBie3OjeR?= NGPZeXY1QCCqcoO= NFvLfoFCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDN[Yxidm:vYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSTC9JFAvOTZizszNMi=> Mom4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
Melanoma cells M4XH[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVHJXYppT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdWWuYX7vcYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zNjFOwG0v NGPDS2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OFU6QSd-MkC2PFQ2QTl:L3G+
Melanoma cells MmjWR5l1d3SxeHnjbZR6KGG|c3H5 MVW0PEBpenN? M1\kZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whT0l3MDC9JFAvOTZizszNMi=> MojLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NEe3OFkoRjJ2N{S3O|Q6RC:jPh?=
Melanoma cells MorTR5l1d3SxeHnjbZR6KGG|c3H5 NUjSO4JVPDhiaILz NXP4O292S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdWWuYX7vcYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zNjFOwG0v NUPkT2Q2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
A549 NV;LfW1MSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{P2elQ5KGi{cx?= NYfYXY0{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE4OTVizszNMi=> NFHobXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzOyd-MkiwN|g{OjN:L3G+
NSCLC NXj2R5h7SW62aYT1cY9zKGG|c3H5 M1rZdVQ5KGi{cx?= MXjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQU1PMR{Bk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTUA:KDBwMkWg{txONg>? NGn0d4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
NSCLC NEn2RpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\2b45rPDhiaILz MofoS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMD6yOUDPxE1w NFjLeJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OFU6QSd-MkC2PFQ2QTl:L3G+
NSCLC NXTFcHptS3m2b4TvfIlkcXS7IHHzd4F6 M{fDeFQ5KGi{cx?= M4HXemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygS2k2OCB;IECuNlUh|ryPLh?= NGXjc4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q{OCd-MkKyPFM1OzB:L3G+
NSCLC NH[0XppEgXSxdH;4bYNqfHliYYPzZZk> MnHsOFghcHK| M2PpcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygS2k2OCB;IECuNlUh|ryPLh?= M2fpfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
NSCLC MnnkRY51cXS3bX;yJIF{e2G7 MmLmRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgUnNEVENiY3XscJMtKEeLNUCgQUAxNjJ3MUG5JO69VS5? M{HmWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
NSCLC MY\BcpRqfHWvb4KgZZN{[Xl? MkHwOFghcHK| NUTHfJhuSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvOjVzMUmg{txONg>? Mo\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
Non-small cell lung carcinoma cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOc44ue22jbHygZ4VtdCCudX7nJINiemOrbn;tZUBk\WyuczygS2k2OCB;IECuNlUyOTlizszNMi=> M{C3cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
ovarian cancer cells MUTDfZRwfG:6aXPpeJkh[XO|YYm= M1T0PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI93[XKrYX6gZ4Fv[2W{IHPlcIx{NCCJSUWwJF0hOC5|MU[yN{DPxE1w NXzQOnFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
renal cancer cells NV3nSYdES3m2b4TvfIlkcXS7IHHzd4F6 MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOsJGdKPTBiPTCwMlMyPjJ|IN88UU4> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
breast cancer cells M1T2WWN6fG:2b4jpZ4l1gSCjc4PhfS=> MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzMEBIUTVyIE2gNE4{OTZ{MzFOwG0v M{TUWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
ovarian cancer cells MoS4RY51cXS3bX;yJIF{e2G7 NVXRbnBmPDhiaILz MXXBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCxdnHybYFvKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6zNVYzOyEQvF2u NFnuXIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells MlXURY51cXS3bX;yJIF{e2G7 NWPxOHE1PDhiaILz M13jO2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIILlcoFtKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6zNVYzOyEQvF2u M1nBd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
breast cancer cells NGrkVY1CdnSrdIXtc5Ih[XO|YYm= MnvsOFghcHK| M3j0fWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLy[YF{fCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuN|E3OjNizszNMi=> NGXDOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells NFvjeYJCdnSrdIXtc5Ih[XO|YYm= NVzTfVI1SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhemWwYXygeJVud3JiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? NWC5NWdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
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Melanoma cells M3;KWmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVO0PEBpenN? MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDt[Yxidm:vYTDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEeuPVQh|ryPLh?= NHnGdoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q{OCd-MkKyPFM1OzB:L3G+
breast cancer cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= Mn\FOFghcHK| NYLNNI1US3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEeuPVQh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
Melanoma cells NIPYc5ZCdnSrdIXtc5Ih[XO|YYm= MoDCOFghcHK| M2HHbGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3lcIFvd22jIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKFSJSTC9JFcvQTR|Mkig{txONg>? M4PhNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
Melanoma cells NFHkeHFEgXSxdH;4bYNqfHliYYPzZZk> NEDPcWxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBu\Wyjbn;tZUBk\WyuczygWGdKKD1iNz65OFMzQCEQvF2u NXHTXIx1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
breast cancer cells M1fQfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkDUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZpJm[XO2IHPhcoNmeiClZXzsd{whXEeLIE2gO{46PDN{ODFOwG0v M2\tRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
breast cancer cells MlT5RY51cXS3bX;yJIF{e2G7 M{fSS|Q5KGi{cx?= NYDUN|AxSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRpJm[XO2IHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTC3Mlk1OzJ6IN88UU4> NHXyXmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
Melanoma cells NVr6VnBxSW62aYT1cY9zKGG|c3H5 M4DD[2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1mdGGwb33hJINmdGy|LDDUS2khRSB5Lkm0N|I5KM7:TT6= M{Dn[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
breast tumor cells MoG2RY51cXS3bX;yJIF{e2G7 MX;BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDidoVie3RidIXtc5Ih[2WubIOsJHRIUSB;IEeuPVQ{OjhizszNMi=> NIHGXpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
NSCLC MoD1RY51cXS3bX;yJIF{e2G7 NUjLO2NvSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhVlOFTFOgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= NXziS2Y6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
Leukemia cells NVTld2JsSW62aYT1cY9zKGG|c3H5 MnnOOFghcHK| MljJRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTHX1b4VucWFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhXEeLIE2gNVUvQDR6OTFOwG0v NFvYU2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
NSCLC M2nQOmFvfGm2dX3vdkBie3OjeR?= MUO0PEBpenN? NG\JZZJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTCxOU45PDh7IN88UU4> M1vDVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
Non-small cell lung carcinoma cells MkezR5l1d3SxeHnjbZR6KGG|c3H5 M{HDfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5wdi2|bXHscEBk\WyuIHz1coch[2G{Y3nuc41iKGOnbHzzMEBVT0liPTCxOU45PDh7IN88UU4> NGP4OZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
Leukemia cells MXrDfZRwfG:6aXPpeJkh[XO|YYm= M1j3fGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|LDDUS2khRSBzNT64OFg6KM7:TT6= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
Leukemia cells MV\BcpRqfHWvb4KgZZN{[Xl? MWXBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDs[ZVs\W2rYTDj[YxteyxiVFfJJF0hOTVwOES4PUDPxE1w MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3OUKwOUc,OTd3NUmyNFU9N2F-
NSCLC M4PjOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7TOFghcHK| M1;3TGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= M1\iNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
Leukemia cells MmT3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFf5WVg1QCCqcoO= NX\xTm9uT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyPS56NTFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
NSCLC NUTtdZNRS3m2b4TvfIlkcXS7IHHzd4F6 MVO0PEBpenN? NImzXXpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPW0OOQzDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEG1Mlg2KM7:TT6= NXTYTIF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
Leukemia cells MoTYR5l1d3SxeHnjbZR6KGG|c3H5 NWTDO2NEPDhiaILz NYG1N|BpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyPS56NTFOwG0v M1PxSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
NSCLC NHz1ZZREgXSxdH;4bYNqfHliYYPzZZk> NF31bJU1QCCqcoO= MkXpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzNT64OUDPxE1w NUXLSlVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
Leukemia cells MV3DfZRwfG:6aXPpeJkh[XO|YYm= M1\0N|Q5KGi{cx?= M3y2WGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gNVUvQDVizszNMi=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
renal cancer cells Ml3hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrQWZo1QCCqcoO= MUjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyQS57NTFOwG0v MmnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
ovarian cancer cells M{PSOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDBOFghcHK| NY\CdIozT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hV3[jcnnhckBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBVT0liPTCxPU46PSEQvF2u M1;yVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
renal cancer cells NFL2dnJEgXSxdH;4bYNqfHliYYPzZZk> MUC0PEBpenN? M1PDU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF7Lkm1JO69VS5? Mlu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NEe3OFkoRjJ2N{S3O|Q6RC:jPh?=
ovarian cancer cells MmHOR5l1d3SxeHnjbZR6KGG|c3H5 MnOwOFghcHK| M3n2[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI93[XKrYX6gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUmuPVUh|ryPLh?= M3K3fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
renal cancer cells M4G5cGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYm0PEBpenN? M4TtVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF7Lkm1JO69VS5? NYHTTIJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
ovarian cancer cells NE\kV29EgXSxdH;4bYNqfHliYYPzZZk> MXG0PEBpenN? NWfxTpZCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hd3[jcnnhckBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBVT0liPTCxPU46PSEQvF2u NGDOVXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q{OCd-MkKyPFM1OzB:L3G+
ovarian cancer cells Mkn5R5l1d3SxeHnjbZR6KGG|c3H5 NEDJcHREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyxiVFfJJF0hOTlwOUWyOkDPxE1w M2DVW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
renal cancer cells NFLmWZZEgXSxdH;4bYNqfHliYYPzZZk> M{XlUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{whXEeLIE2gNVkvQTV{NjFOwG0v NX3lPHpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
ovarian cancer cells NYHzOpVySW62aYT1cY9zKGG|c3H5 M1rJSVQ5KGi{cx?= NHvwTGNCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDveoFzcWGwIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTCxPU46PTJ4IN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
renal cancer cells NU\ZbJJNSW62aYT1cY9zKGG|c3H5 NFO3fWI1QCCqcoO= Mn62RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icnXuZYwh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIGTHTUA:KDF7Lkm1NlYh|ryPLh?= NXnXZ2pSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
renal tumor cells NXnGOYxKSW62aYT1cY9zKGG|c3H5 NV\lfmtwSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhemWwYXygeJVud3JiY3XscJMtKFSJSTC9JFE6Njl3Mk[g{txONg>? MmThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUmyNFUoRjF5NUW5NlA2RC:jPh?=
ovarian tumor cells NF:yZVlCdnSrdIXtc5Ih[XO|YYm= M1n5cWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI93[XKrYX6geJVud3JiY3XscJMtKFSJSTC9JFE6Njl3Mk[g{txONg>? MmrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUmyNFUoRjF5NUW5NlA2RC:jPh?=
PC3 NHvxO|FEgXSxdH;4bYNqfHliYYPzZZk> NWTnUWdzPDhiaILz NYDwXVhGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK4MlEyKM7:TT6= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF5NEixOkc,OjlzN{S4NVY9N2F-
neural precursor cells NI\md5VHfW6ldHnvckBie3OjeR?= NXjoO3dbUW6qaXLpeIlwdiCxZjDu[ZVzd3OyaHXy[UBxem:uaX\ldoF1cW:wIH;mJI1wfXOnIH7leZJidCCycnXjeZJ{d3JiY3XscJMh[nliTWTUJIF{e2G7 MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1; 

PubMed: 26156322     


MOLT-4 Cells were treated with vincristine (0.3, 1, and 3 nM) alone or co-treated with SAHA (500 nM) for 24 h. Then, total cell lysates were obtained to evaluate the G2/M phase regulatory protein expression and the tubulin acetylation. Data are expressed as mean values ± SD of at least three separate determinations. S SAHA, V vincristine

26156322
Growth inhibition assay
Cell viability ; 

PubMed: 26156322     


MOLT-4 cells were treated with various concentrations of vincristine for 24 and 48 h, respectively.  Cell viability was measured by MTT assay.

26156322
In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
in solvent
Synonyms Leurocristine
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448834 Not yet recruiting Drug: Blinatumomab B-cell Acute Lymphoblastic Leukemia David Rizzieri MD|Amgen|Acrotech Biopharma LLC|Duke University December 15 2020 Phase 2
NCT03981510 Recruiting Diagnostic Test: 3D-Transit Constipation|Childhood Acute Lymphoblastic Leukemia|Neurofibromatosis 1|Chronic Constipation With Overflow University of Aarhus June 13 2019 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • Answer:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID