Vincristine (NSC-67574) sulfate

For research use only.

Catalog No.S1241 Synonyms: Leurocristine, Oncovin, 22-Oxovincaleukoblastine

79 publications

Vincristine (NSC-67574) sulfate Chemical Structure

CAS No. 2068-78-2

Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.

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Selleck's Vincristine (NSC-67574) sulfate has been cited by 79 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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NCI-H1299/pcDNA3 NHuwPG5HfW6ldHnvckBCe3OjeR?= M1rxeFEwPS9zMD:yNOKhdk1? NHvrbHE6PiCq MYLpcoR2[2W|IHPs[YF3[WenIH;mJINie3Cjc3XzMVMtKDhuIEmsJIFv\CCSQWLQ MoXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzN{ewNVIoRjJ2MUe3NFEzRC:jPh?=
H1299/ICAM-3 MoDFSpVv[3Srb36gRZN{[Xl? Mn7hNU82NzFyL{KwxsBvVQ>? NELLNWQ6PiCq Mo\hbY5lfWOnczDjcIVifmGpZTDv[kBk[XOyYYPld{0{NCB6LDC5MEBidmRiUFHSVC=> M{e0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUe3NFEzLz5{NEG3O|AyOjxxYU6=
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K562 NYrkT25vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEOyJOKyKDBwMECxJEDPxE1? NGjuUo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzOVk{Pyd-MkSxN|U6Ozd:L3G+
K562/ADR NGjoRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXoVoJKSzVyPUOuNlYyKMLzIECuOFEzKM7:TR?= NV\SNG85RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|U6OzdpPkK0NVM2QTN5PD;hQi=>
K562 MVXBdI9xfG:|aYOgRZN{[Xl? NGS5cW0xNjNizszN MXuyOEBp Mk\xbY5lfWOnczDhdI9xfG:|aYOgd4lodmmoaXPhcpRtgQ>? NHXsVWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzOVk{Pyd-MkSxN|U6Ozd:L3G+
K562/ADR MW\BdI9xfG:|aYOgRZN{[Xl? NVewSFFqOyEQvF2= M2T3NVI1KGh? Mm\CbY5lfWOnczDhdI9xfG:|aYO= NGXTXIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzOVk{Pyd-MkSxN|U6Ozd:L3G+
A549 NHXafXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnYPIVjUUN3ME2wMlExKMLzIECuNFMh|ryP MoHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7N{GwO|UoRjJ|OUexNFc2RC:jPh?=
K562 NY\MS49pS2WubDDWbYFjcWyrdImgRZN{[Xl? M1mwdVMvPzYkgKO2NOKhdk1? MYG3NuKhcMLi M3vFcIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NUT1S4lnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|czOjNpPkKzPFc4OjJ|PD;hQi=>
lucena MkDxR4VtdCCYaXHibYxqfHliQYPzZZk> MVyzMlc26oDVNkFCpI5O NHXOdYg4OsLiaNMg NFnibnNvdyCnZn\lZ5Q> NWfMS|ZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|czOjNpPkKzPFc4OjJ|PD;hQi=>
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A2780 NFe2WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPLTWM2OD1|LkWgcW0> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh{OUKwN{c,OjN6MkmyNFM9N2F-
ACHN M3W3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\WTWM2ODxyLkGgcW0> M1XLU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEK5NlA{Lz5{M{iyPVIxOzxxYU6=
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Jurkat NHXSWJdCeG:ydH;zbZMhSXO|YYm= NXXSVXdpPcLizsznM41tyqB? NHvXUnAzPCCq NInPblFqdmS3Y3XzJIFxd3C2b4Ppd{B{cWewaX\pZ4FvfGy7 NX7RRmsyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVA1ODlpPkKzPFExPDB7PD;hQi=>
Jurkat M2fhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LRblXDqM7:Zz;tcOKh MkPINlQhcA>? NHWyfXhienKnc4SgTpVzc2G2IHPlcIx{KGmwIFeyM20heGijc3W= MnTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUC0NFkoRjJ|OEGwOFA6RC:jPh?=
Hep-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz1bWVKSzVyPUCuNFTDuTBwMEGg{txO MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6MESyOEc,OjN5OEC0NlQ9N2F-
Hep-2/v NFzzRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\SbFAzUUN3ME2xMljDuTBwMkCg{txO NETGTog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4NFQzPCd-MkO3PFA1OjR:L3G+
SGC-7901 NGnBdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH3eWsxNTFyIN88[{9udA>? MmfZNlQwPDhxN{KgbC=> MkHObY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd2M{W3Nkc,OjN5NEO1O|I9N2F-
SGC-7901/VCR NHv2ZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq3dlYxNTFyIN88[{9udA>? M1fhflI1NzR6L{eyJIg> MYXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd2M{W3Nkc,OjN5NEO1O|I9N2F-
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KB-3-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rBdmlEPTB;MT62OkDDuSByLkG2NkDPxE1? MnH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4N{O0OFUoRjJ|NkezOFQ2RC:jPh?=
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HEK293/pcDNA3.1 M1j0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDoTWM2OD1{ND6xJOKyKDBwMkC0JO69VQ>? NUPpPGw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2O|M1PDVpPkKzOlc{PDR3PD;hQi=>
HEK293/ABCB1 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD3XmpFUUN3ME2zOVEzNjhiwsGgN|c5NjN7MTFOwG0> NXXPfZg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2O|M1PDVpPkKzOlc{PDR3PD;hQi=>
A549/EGFP  MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW3OXkxNjBzLUGwNFAh|ryP NWP0c45QUUN3ME24Ok44KMLzIEK5MlEh|ryP NEPmeW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[zOFI5Oid-MkO2N|QzQDJ:L3G+
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JFCR39  M1L4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjMVIkyKML3TR?= MkXqNlQhcA>? M1jsdmROW09? NFH1dFJu[XKtZXTsfUBqdmO{ZXHz[ZMhfGinIH71cYJmeiCxZjDHNk9OKHCqYYPlJINmdGy| NW\WTZJMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVgzPzZpPkKzOVk5Ojd4PD;hQi=>
A549 NETtWlNHfW6ldHnvckBCe3OjeR?= NYHtcVc5OTByIH7N NHnQUFYyPiCq NYjaS4tWTE2VTx?= MX;s[YFleyC2bzDhJIxwe3Nib3[gcYlkem:2dXL1cIV{ NYXXNpJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVgzPzZpPkKzOVk5Ojd4PD;hQi=>
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SGC7901/LV-NC M2PIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rVUmlEPTB;MT63O-KBkcLz4pEJNE4yPiEQvHevcYw> NWPGSmdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OlQ1QDJpPkKzOVY1PDh{PD;hQi=>
SGC7901/LV-SGO1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\XTWM2OD12LkO25qCKyrIkgJmwMlM4KM7:Zz;tcC=> NVn3b441RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OlQ1QDJpPkKzOVY1PDh{PD;hQi=>
SGC7901/VCR Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXDU4JKSzV|PUKwMlU{6oDLwsJihKkyNjl4IN88[{9udA>? NEfGbmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2OFQ5Oid-MkO1OlQ1QDJ:L3G+
SGC7901/VCR-NC M2rzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSxfmFKSzVyPUG5Mlg36oDLwsJihKkzNjBzIN88[{9udA>? Ml7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NkS0PFIoRjJ|NU[0OFgzRC:jPh?=
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Melanoma cells MoTTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWTsOJBHT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdWWuYX7vcYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zNjFOwG0v NWSwfnlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
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Melanoma cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= MoraOFghcHK| M1jQcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whT0l3MDC9JFAvOTZizszNMi=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
A549 M2HYeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFf6cnE1QCCqcoO= M{m0[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xO|E2KM7:TT6= MlPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
NSCLC MkTmRY51cXS3bX;yJIF{e2G7 NITF[VY1QCCqcoO= MUjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQU1PMR{Bk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTUA:KDBwMkWg{txONg>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
NSCLC MlTKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX:0PEBpenN? M37aTGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygS2k2OCB;IECuNlUh|ryPLh?= Mnv0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
NSCLC M2jwe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmH1OFghcHK| MljaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMD6yOUDPxE1w M{P2TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFMxLz5{MkK4N|Q{ODxxYU6=
NSCLC NGfEXGtEgXSxdH;4bYNqfHliYYPzZZk> MljCOFghcHK| MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkK1JO69VS5? M3fDOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
NSCLC NXroUXJoSW62aYT1cY9zKGG|c3H5 M3WyfGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JG5US0yFIHPlcIx{NCCJSUWwJF0hOC5{NUGxPUDPxE1w NE[1b2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
NSCLC NIPkNXdCdnSrdIXtc5Ih[XO|YYm= M2[zPFQ5KGi{cx?= NEmwVFVCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4zPTFzOTFOwG0v MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
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ovarian cancer cells NYHmZVBDS3m2b4TvfIlkcXS7IHHzd4F6 M1LCTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI93[XKrYX6gZ4Fv[2W{IHPlcIx{NCCJSUWwJF0hOC5|MU[yN{DPxE1w NF30NYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
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renal cancer cells MlPMRY51cXS3bX;yJIF{e2G7 NGHzTpc1QCCqcoO= NV\tfYJ3SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlMyPjJ|IN88UU4> NXXKN3FyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
breast cancer cells M1TwZWFvfGm2dX3vdkBie3OjeR?= NXLyTXJIPDhiaILz NVPLW2NmSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRpJm[XO2IHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4{OTZ{MzFOwG0v MlPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
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Melanoma cells M2TrSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3XNc|Q5KGi{cx?= M2PJXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gO{46PCEQvF2u M3fmVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
Melanoma cells M{XNR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1y0SFQ5KGi{cx?= NHnMbGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBu\Wyjbn;tZUBk\WyuczDh[pRmeiB2ODDodpMtKFSJSTC9JFcvQTRizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
breast cancer cells MVXDfZRwfG:6aXPpeJkh[XO|YYm= NHKwXWM1QCCqcoO= MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyxiVFfJJF0hPy57NDFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
Melanoma cells NWrVeIJ{SW62aYT1cY9zKGG|c3H5 M4LudlQ5KGi{cx?= NIrDVlBCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDN[Yxidm:vYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCWR1mgQUA4Njl2M{K4JO69VS5? NXrIe4IxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Melanoma cells M3S4bmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDt[Yxidm:vYTDj[YxteyxiVFfJJF0hPy57NEOyPEDPxE1w NELWPXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
breast cancer cells NF2y[4xEgXSxdH;4bYNqfHliYYPzZZk> MmHCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZpJm[XO2IHPhcoNmeiClZXzsd{whXEeLIE2gO{46PDN{ODFOwG0v MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
breast cancer cells M3fhTmFvfGm2dX3vdkBie3OjeR?= M{W4dlQ5KGi{cx?= NVfOToQ4SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRpJm[XO2IHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTC3Mlk1OzJ6IN88UU4> NXvHTlVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Melanoma cells NULDS2MzSW62aYT1cY9zKGG|c3H5 NILOXW9CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBu\Wyjbn;tZUBk\WyuczygWGdKKD1iNz65OFMzQCEQvF2u NILmUoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
breast tumor cells MV7BcpRqfHWvb4KgZZN{[Xl? MX\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDidoVie3RidIXtc5Ih[2WubIOsJHRIUSB;IEeuPVQ{OjhizszNMi=> NX7pUlZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
NSCLC NVHaTZlKSW62aYT1cY9zKGG|c3H5 NUn4OFMzSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhVlOFTFOgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= M1riNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
Leukemia cells MX3BcpRqfHWvb4KgZZN{[Xl? MWS0PEBpenN? MWHBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOZYXr[Y1q[SClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTCxOU45PDh7IN88UU4> NGSyNVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
NSCLC MUPBcpRqfHWvb4KgZZN{[Xl? MmW1OFghcHK| NH7ydWJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTCxOU45PDh7IN88UU4> NVrJPXM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Non-small cell lung carcinoma cells Mn\VR5l1d3SxeHnjbZR6KGG|c3H5 MkTrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUo9vNXOvYXzsJINmdGxibIXu[{Bk[XKlaX7vcYEh[2WubIOsJHRIUSB;IEG1Mlg1QDlizszNMi=> NEjoS|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
Leukemia cells M{Pr[GN6fG:2b4jpZ4l1gSCjc4PhfS=> MojWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
Leukemia cells MnG3RY51cXS3bX;yJIF{e2G7 MkWzRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcIV2c2WvaXGgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= NVX1e2V[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
NSCLC M3jLNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIrldWU1QCCqcoO= Mn3WS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzNT64OUDPxE1w MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
Leukemia cells MnXvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nUNlQ5KGi{cx?= MXrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEG1Mlg2KM7:TT6= M170NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
NSCLC NIP3R3JEgXSxdH;4bYNqfHliYYPzZZk> M{i0WFQ5KGi{cx?= M2XDdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= MmTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
Leukemia cells NVKwSmszS3m2b4TvfIlkcXS7IHHzd4F6 Mk\ZOFghcHK| NXL6VIE2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyPS56NTFOwG0v MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
NSCLC NX7JS|VSS3m2b4TvfIlkcXS7IHHzd4F6 NFjoWoQ1QCCqcoO= MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF3Lki1JO69VS5? NVTqWmZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
Leukemia cells NX3mTGVpS3m2b4TvfIlkcXS7IHHzd4F6 NYPIemNZPDhiaILz NF7DRpVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMtKFSJSTC9JFE2Njh3IN88UU4> NX;lNVNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
renal cancer cells M1zuW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmH3OFghcHK| NHjrSYtIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzOT65OUDPxE1w NEPyXGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OFU6QSd-MkC2PFQ2QTl:L3G+
ovarian cancer cells NWrvR3Z6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVGySppRPDhiaILz MVfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDPeoFzcWGwIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF7Lkm1JO69VS5? NXnZT2FuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
renal cancer cells Mn3ZR5l1d3SxeHnjbZR6KGG|c3H5 NVnrXJA4PDhiaILz MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyQS57NTFOwG0v Mkm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NEe3OFkoRjJ2N{S3O|Q6RC:jPh?=
ovarian cancer cells MmK5R5l1d3SxeHnjbZR6KGG|c3H5 MXe0PEBpenN? NVi3O|h{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hd3[jcnnhckBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBVT0liPTCxPU46PSEQvF2u MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
renal cancer cells MY\DfZRwfG:6aXPpeJkh[XO|YYm= NEWybYg1QCCqcoO= NYfueJJSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUmuPVUh|ryPLh?= Ml7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
ovarian cancer cells MknJR5l1d3SxeHnjbZR6KGG|c3H5 MYW0PEBpenN? M4nqe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI93[XKrYX6gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUmuPVUh|ryPLh?= MlHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
ovarian cancer cells NVXVXpRVS3m2b4TvfIlkcXS7IHHzd4F6 NWXVdmZYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hd3[jcnnhckBk[W6lZYKgZ4VtdHNuIGTHTUA:KDF7Lkm1NlYh|ryPLh?= MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
renal cancer cells NHfofHREgXSxdH;4bYNqfHliYYPzZZk> Mkf5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzMEBVT0liPTCxPU46PTJ4IN88UU4> MmDjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUiwNVgoRjF6NUm4NFE5RC:jPh?=
ovarian cancer cells NX\KcHVvSW62aYT1cY9zKGG|c3H5 MWe0PEBpenN? NEi3dYxCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDveoFzcWGwIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTCxPU46PTJ4IN88UU4> NInLOoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal cancer cells M2G3U2FvfGm2dX3vdkBie3OjeR?= NHHMW3c1QCCqcoO= M4fEW2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIILlcoFtKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDUS2khRSBzOT65OVI3KM7:TT6= NIPFZYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
renal tumor cells NWnOUmh5SW62aYT1cY9zKGG|c3H5 MWDBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDy[Y5idCC2dX3vdkBk\WyuczygWGdKKD1iMUmuPVUzPiEQvF2u NWX6bFNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
ovarian tumor cells NHK2fnZCdnSrdIXtc5Ih[XO|YYm= MonHRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sgc5ZiemmjbjD0eY1weiClZXzsd{whXEeLIE2gNVkvQTV{NjFOwG0v NHrBOYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
PC3 MoPPR5l1d3SxeHnjbZR6KGG|c3H5 NEP6Vms1QCCqcoO= M{XwPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{OD6xNUDPxE1w NXzWWXVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxO|Q5OTZpPkK5NVc1QDF4PD;hQi=>
neural precursor cells MX;GeY5kfGmxbjDhd5NigQ>? NYHUc|JSUW6qaXLpeIlwdiCxZjDu[ZVzd3OyaHXy[UBxem:uaX\ldoF1cW:wIH;mJI1wfXOnIH7leZJidCCycnXjeZJ{d3JiY3XscJMh[nliTWTUJIF{e2G7 Mn\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUe2N|EoRjF5NEG3OlMyRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1; 

PubMed: 26156322     


MOLT-4 Cells were treated with vincristine (0.3, 1, and 3 nM) alone or co-treated with SAHA (500 nM) for 24 h. Then, total cell lysates were obtained to evaluate the G2/M phase regulatory protein expression and the tubulin acetylation. Data are expressed as mean values ± SD of at least three separate determinations. S SAHA, V vincristine

26156322
Growth inhibition assay
Cell viability ; 

PubMed: 26156322     


MOLT-4 cells were treated with various concentrations of vincristine for 24 and 48 h, respectively.  Cell viability was measured by MTT assay.

26156322
In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
in solvent
Synonyms Leurocristine, Oncovin, 22-Oxovincaleukoblastine
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448834 Not yet recruiting Drug: Blinatumomab B-cell Acute Lymphoblastic Leukemia David Rizzieri MD|Amgen|Acrotech Biopharma LLC|Duke University April 1 2021 Phase 2
NCT02360930 Unknown status -- Leukemia Acute Lymphoblastic|Leukemia Children''s Hospital Los Angeles September 2014 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • Answer:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID