JG98

Catalog No.S6721

For research use only.

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

JG98 Chemical Structure

CAS No. 1456551-16-8

Purity & Quality Control

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Biological Activity

Description JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
Targets
Hsp70 [1]
()
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 MlLFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTBwM{pOwG0v MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTl3M{iwPEc,Ojl7NUO4NFg9N2F-
MDA-MB-231 NWXHVYtlS3m2b4TvfIlkcXS7IHHzd4F6 MV:3NkBpenN? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;MD60{txONg>? NXnWfIU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVI3QTlpPkK0N|EzPjl7PD;hQi=>
MCF7 NYj3fWlxS3m2b4TvfIlkcXS7IHHzd4F6 MYG3NkBpenN? MnzSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwQVAvP87:TT6= M{\pNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{GyOlk6Lz5{NEOxNlY6QTxxYU6=
MCF7 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NV\j[WFuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjdzzszNMi=> M1O4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUWzPFA5Lz5{OUm1N|gxQDxxYU6=
MEF NUG2e5dkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGD6TGlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JG1GTiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:PC5{zszNMi=> M2rZNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUWzPFA5Lz5{OUm1N|gxQDxxYU6=
MDA-MB-231 NUjOcZE5SXW2b4DoZYdq[yCjc4PhfS=> NGr0SIg2KHSxIEGwJJVO NH;HPIozPCCqcoO= MX\JcoR2[3Srb36gc4Yh[XW2b4DoZYdq[yCobIX4JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icE[yJI9tcWexbXXybZpifGmxbjDheEA2KHSxIEGwJJVOKGGodHXyJFI1KGi{cx?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzMk[5PUc,OjR|MUK2PVk9N2F-
MDA-MB-231 M37a[2Fxd3C2b4Ppd{Bie3OjeR?= MUmxNEB2VQ>? NXvpNYQxPDhiaILz MVrJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNiY3HzdIF{\S1|IHPs[YF3[WenIHH0JFExKHWPIHHmeIVzKDR6IHjydy=> M2n4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{GyOlk6Lz5{NEOxNlY6QTxxYU6=
MCF7 NXjndWQzSXW2b4DoZYdq[yCjc4PhfS=> MnPBOUB1dyBzMDD1US=> M1e2PFI1KGi{cx?= M3S0fWlv\HWldHnvckBw\iCjdYTvdIhi\2mlIH\seZghcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBxPjJib3zp[49u\XKrenH0bY9vKGG2IEWgeI8hOTBidV2gZYZ1\XJiMkSgbJJ{ M{e2TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{GyOlk6Lz5{NEOxNlY6QTxxYU6=
MDA-MB-231 NEjU[2JCeG:ydH;zbZMh[XO|YYm= M2\vWVExKHWP NHPse|U1QCCqcoO= MXXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNiUFHSVEBkdGWjdnHn[UBifCBzMDD1UUBi\nSncjC0PEBpenN? NVjJcnp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVI3QTlpPkK0N|EzPjl7PD;hQi=>
MCF7 M{\OVGF2fG:yaHHnbYMh[XO|YYm= M{LhTlUhfG9iMUCgeW0> MnvxNlQhcHK| NHvPNJFKdmS3Y4Tpc44hd2ZiYYX0c5Bp[WerYzDmcJV5KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heDZ{IH3vco9u\XJibHX2[Ywh[XRiNTD0c{AyOCC3TTDh[pRmeiB{NDDodpM> NW\v[lZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVI3QTlpPkK0N|EzPjl7PD;hQi=>
MDA-MB-231 M1;sTWF2fG:yaHHnbYMh[XO|YYm= M1ThdFUhfG9iMUCgeW0> MmLQNlQhcHK| MljvTY5lfWO2aX;uJI9nKGG3dH;wbIFocWNiZnz1fEBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIIC2NkBud26xbXXyJIxmfmWuIHH0JFUhfG9iMUCgeW0h[W[2ZYKgNlQhcHK| M1vGZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{GyOlk6Lz5{NEOxNlY6QTxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 8 mg/mL
(14.96 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 534.54
Formula

C24H21Cl2N3OS3

CAS No. 1456551-16-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1C(=CC2=[N+](C=CS2)CC3=CC=CC=C3)SC(=C4N(C5=C(S4)C=C(C=C5)Cl)C)C1=O.[Cl-]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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