JG98

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

JG98 Chemical Structure

JG98 Chemical Structure

CAS: 1456551-16-8

Selleck's JG98 has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.91%
99.91

JG98 Related Products

Choose Selective HSP (HSP90) Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 Antiproliferative assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay, IC50=0.39μM. 29953808
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay, EC50=0.4μM. 24312699
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, EC50=0.7μM. 24312699
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells by MTT assay, IC50=0.71μM. 29953808
MEF Antiproliferative assay Antiproliferative activity against MEF cells by MTT assay, IC50=4.2μM. 29953808
MDA-MB-231 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MDA-MB-231 cells assessed as increase in p62 oligomerization at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Apoptosis assay 10 uM 48 hrs Induction of apoptosis in human MDA-MB-231 cells assessed as caspase-3 cleavage at 10 uM after 48 hrs 24312699
MCF7 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MCF7 cells assessed as increase in p62 oligomerization at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Apoptosis assay 10 uM 48 hrs Induction of apoptosis in human MDA-MB-231 cells assessed as PARP cleavage at 10 uM after 48 hrs 24312699
MCF7 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MCF7 cells assessed as decrease in p62 monomer level at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MDA-MB-231 cells assessed as decrease in p62 monomer level at 5 to 10 uM after 24 hrs 24312699
Click to View More Cell Line Experimental Data

Biological Activity

Description JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
Targets
Hsp70 [1]

Chemical Information & Solubility

Molecular Weight 534.54 Formula

C24H21Cl2N3OS3

CAS No. 1456551-16-8 SDF --
Smiles CCN1C(=CC2=[N+](C=CS2)CC3=CC=CC=C3)SC(=C4N(C5=C(S4)C=C(C=C5)Cl)C)C1=O.[Cl-]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (18.7 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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