Daunorubicin HCl

For research use only.

Catalog No.S3035 Synonyms: Daunomycin HCl

38 publications

Daunorubicin HCl Chemical Structure

CAS No. 23541-50-6

Daunorubicin HCl (Daunomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

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Selleck's Daunorubicin HCl has been cited by 38 publications

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Biological Activity

Description Daunorubicin HCl (Daunomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
Targets
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
In vitro

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 leukemia cell line MXTDfZRwfG:6aXRCpIF{e2G7 MVTDc41xd3WwZDD3ZZMh\X[jbIXheIVlKG[xcjDjfZRwfG:6aXPpeJkh[WejaX7zeEBROzh6IHzleYtmdWmjIHPlcIwhdGmwZTygTWM2OD1|IH7N NE\pZ3YyODR5OUK5Oy=>
HL60 cells NF;WO4FHfW6ldHnvckBie3OjeR?= NGrFeWFKdiC4aYTyc{BqdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDwdo9tcW[ncnH0bY9vKG:oIFjMOlAh[2WubIOsJGlEPTB;MD6wNFUh|ryP MVqxNlg4PzV7Mx?=
human epidermoid carcinoma cell line KB-3-1 NWLXSJFbS3m2b4TvfIlkyqCjc4PhfS=> NFTXOY1KdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5iZYDp[IVzdW:rZDDjZZJkcW6xbXGgZ4VtdCCuaX7lJGtDNTNvMTygTWM2OD15IH7N MVixNlQ1Ozd4Mx?=
human K562 cells M1\MZWN6fG:2b4jpZ:Kh[XO|YYm= Mmf3O|IhcA>? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDYWHQh[XO|YYmsJGdKPTB;Nz60JI5O M3fH[VIxPTlzNke4
Dx5 w/PSC cell lines M2LtT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV;UbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGR5PSC5L2DTR{Bk\WyuIHzpcoV{KHW|aX7nJG1VXCCjc4PhfUwhUUN3ME2xOEBvVQ>? NXTNUnFNOTB4OUi0OFk>
MDA MB 361(mammary carcinoma cell line) NXrnWo1iS3m2b4TvfIlkyqCjc4PhfS=> Mk\LWIhmKGOxbYDveY5lKHejczD0[ZN1\WRiZn;yJIlvfHKjY3XscJVt[XJiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgUWRCKE2EIEO2NUhu[W2vYYL5JINiemOrbn;tZUBk\WyuIHzpcoUqKGW6cILld5NqdmdiTHHjXkAp[mW2YT3nZYxi[3Sxc3nkZZNmMSxiSVO1NF0yPyCwTR?= NHvTSIMyODN7NUS5NC=>
human MDA-MB-231 cells NX3HNnMyS3m2b4TvfIlkyqCjc4PhfS=> M2Oxd|czKGh? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUCuNFIh|ryP Mk\2NVk6Pjh{NUi=
MES-SA uterine tumor cell lines NIPxVpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPUbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJG1GWy2VQTD1eIVzcW6nIIT1cY9zKGOnbHygcIlv\XNidYPpcochVVSWIHHzd4F6NCCLQ{WwQVAvODJzIN88US=> M3G3T|ExPjl6NES5
murine L1210 leukemia cells MUPGeY5kfGmxbjDhd5NigQ>? MVvJcohq[mm2b4L5JIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KG23cnnu[UBNOTJzMDDs[ZVs\W2rYTDj[YxteyxiSVO1NF0{OCCwTR?= M2LF[Fk4OzN2OEO=
HL60 cells NGHhVIpHfW6ldHnvckBie3OjeR?= NV:1TnBXUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmS3Y3WgZZBweHSxc3nzJIlvKEiONkCgZ4VtdHNuIFHDOVA:OC5yNDFOwG0> M4jORVEzQDd5NUmz
CCRF-CEM (human lymphoblastic leukemic) cells NUPwb2hwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkT1TY4hfmm2cn:g[5Jwf3SqIHnubIljcXSxcomgZYN1cX[rdImgZYdicW6|dDDDR3JHNUOHTTCobJVu[W5ibIntdIhw[myjc4TpZ{Bt\XWtZX3pZ{kh[2WubIOsJGlFPTB;MD6wOEDPxE1? MkPUOlk2OTB2OR?=
mouse NIH/3T3 cells MV\DfZRwfG:6aXRCpIF{e2G7 MV:3NkBp MU\JcpRzcW6|aXOgZ5l1d3SxeHnjbZR6KGGpYXnud5Qhf2muZDD0fZBmKG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjB2NDFOwG0> NFjCNmMyQDl3NEC0NC=>
human prostate cancer HTB-81 cells NVfQdGRES3m2b4TvfIlkyqCjc4PhfS=> M{XBZ2N6fG:2b4jpZ4l1gSC2aHH0JINifXOnZDDhJFUxLSC{ZXT1Z5Rqd25iaX6gZYJ{d3KkYX7j[UBifCB2OUCgco0hcW5iaIXtZY4heHKxc4TheIUh[2GwY3XyJGhVSi16MTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUC9NE4xPThizszN NWfw[ldNOTFyMkCyPFU>
human breast carcinoma line cells MmPoSpVv[3Srb36gZZN{[Xl? M{HWcYNwdXCxdX7kJJdieyC2ZYP0[YQhcW5idnn0do8h\m:{IHnubIljcXSrb36gZYN1cX[rdImgZYdicW6|dDDhJJNmdnOrdHn2[UBpfW2jbjDidoVie3RiY3HyZ4lvd22jIHzpcoUh[2WubIOsJGlEPTB;MD6wOkDPxE1? NWHOOVA6QTJ3OEO1NS=>
MCF-7 cells Mo\GR5l1d3SxeHnjxsBie3OjeR?= NHe3VpZEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDpeJMhfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzLG1ETi15KTygTWM2OD1yLkC2JO69VQ>? NXrZenQxQTV2OEiyNC=>
human HT-29 cells NXzlNY1uS3m2b4TvfIlkyqCjc4PhfS=> M3rwOVczKGh? M{jLbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTBwMEeg{txO MUKxPVk3QDJ3OB?=
human uterine sarcoma cell line MES-SA NVzGUmRYS3m2b4TvfIlkyqCjc4PhfS=> M4Lte2lvKH[rdILvJIN6fG:2b4jpZ{Bi[3Srdnn0fUB4[XNiZY\hcJVifGWmIIXzbY5oKHSqZTDoeY1idiC3dHXybY5mKHOjcnPvcYEh[2WubDDsbY5mKE2HUz3TRUwhUUN3ME2wMlA4KM7:TR?= MYCxNlQ1Ozd4Mx?=
human MRC5 cells NF7pRWNRem:uaX\ldoF1cW:wIHHzd4F6 M2LVXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTWLDOUBk\WyuczDifUBZXFRiYYPzZZktKEmFNUC9NE4xPzhizszN M3S4OVI2PDZ5Mkmx
MDA435/LCC6 cells NWrE[Yg1WHKxbHnm[ZJifGmxbjDhd5NigQ>? NG[yelVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JG1FSTR|NT;MR2M3KGOnbHzzJIJ6KEWOSWPBMEBKSzVyPUCuNFc6KM7:TR?= M3vvOlE4OTV2NUC1
human A549 cells MYXDfZRwfG:6aXRCpIF{e2G7 NEjXNFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTBwMEig{txO MV:xPVk3QDJ3OB?=
Jurkat T lymphocytes NICyNmZEgXSxdH;4bYPDqGG|c3H5 NYHyTYwzS3m2b4TvfIlkcXS7IHHnZYlve3RiSoXyb4F1KFRibIntdIhw[3m2ZYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODh{NjFOwG0> NGnhelgyPjN4Nk[wNi=>
human DU145 cells M4\MNHBzd2yrZnXyZZRqd25iYYPzZZk> M{jCZ|czKGh? NVu0dYV{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFkh|ryP MV6yNlI3ODF4Nh?=
human MDA-MB-231 cells NHn5e3pRem:uaX\ldoF1cW:wIHHzd4F6 NVjUe5RCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JHhVXCCjc4PhfUwhUUN3ME2wMlA6OSEQvF2= M3G3SVI2PDZ5Mkmx
human H1299 cells MkDqVJJwdGmoZYLheIlwdiCjc4PhfS=> MliyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKMUK5PUBk\WyuczDifUBZXFRiYYPzZZktKEmFNUC9NE4xQTZizszN M{j6dVI2PDZ5Mkmx
human HL60 cells MUPDfZRwfG:6aXRCpIF{e2G7 MmPVOFghcA>? NXG2WJlnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nlidIL5dIFvKGKudXWgd5RicW6rbnetZoF{\WRiaHXtc4N6fG:vZYTybYMh[W6jbInzbZMtKEeLNUC9NE4yKM7:TR?= M17KWVI2QDd2M{O1
human LNCAP cells MWLDfZRwfG:6aXRCpIF{e2G7 NUDWV4VRPCCmYYnz NUfVSnlES3m2b4P0ZZRq[yCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGxPS0GSIHPlcIx{KGGodHXyJFQh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE4yKM7:TR?= NFztdY4zOjR6MES5OS=>
NCI-H69 cell line MV7Qdo9tcW[ncnH0bY9vKGG|c3H5 NYKwdIZwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpIIPlcpNqfGm4ZTDOR2kuUDZ7IHPlcIwhdGmwZTDifUBCdGGvYYKgRox2\SCjc4PhfUwhUUN3ME2wMlEh|ryP NE[2NIEyPzJ6NkO5Ny=>
human A2780 cells NIPKfIdEgXSxdH;4bYPDqGG|c3H5 M3r0RVczKGh? MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNVE4PDlizszN NWDwbJZoOTd6OUCwPVQ>
human HT-29 cells MnzlVJJwdGmoZYLheIlwdiCjc4PhfS=> NVTEcXNzQTZiaB?= NHH1UHZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6xN|Mh|ryP MX:yO|c5PDR7
B16 mouse melanoma cells MnmwR5l1d3SxeHnjxsBie3OjeR?= NWjTRoxzS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDCNVYhdW:3c3WgcYVt[W6xbXGgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwQVAvOTZizszN NWnRcpZCOTFyMkCyPFU>
human SKMES1 cells NUfVeFFiWHKxbHnm[ZJifGmxbjDhd5NigQ>? NHLGbFc4OiCq Mm\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVS13FV|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1yLkG3JO69VQ>? NHrEbYEzOjJ4MEG2Oi=>
human fibroblast (NHF) cells MYXDfZRwfG:6aXRCpIF{e2G7 NIDxN4FEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIH7vdo1idCCqdX3hckBncWK{b3LsZZN1KCiQSF[pJINmdGy|IIXzbY5oKE2WUzDhd5NigSxiRVO1NF0xNjJ{IN88US=> NETzbIIyOTB{MEK4OS=>
mouse L1210 cells M1rvZmZ2dmO2aX;uJIF{e2G7 M1XxNGlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{BqdiCvb4Xz[UBNOTJzMDDj[YxteyxiRVS1NF0xNjJ|IN88US=> MUi2PVA6QTl?
human NCI-H460 cells MWrGeY5kfGmxbjDhd5NigQ>? MVfBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMtKEmFNUC9NE4{QCEQvF2= M{TSblIyPTl7MECw
human MCF7 cells M{HTfGN6fG:2b4jpZ:Kh[XO|YYm= M4n2bVQh\GG7cx?= MmnJR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1yLkSg{txO NEHVbFkzOjR6MES5OS=>
human SF268 cells MoHNSpVv[3Srb36gZZN{[Xl? MknoRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPGNlY5KGOnbHzzMEBKSzVyPUCuOkDPxE1? MnXHNlE2QTlyMEC=
human KB cells NWHuVo13S3m2b4TvfIlkyqCjc4PhfS=> MnW0OFghcA>? NF3x[IdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOlQh|ryP NV\Kb5ZDOjB|NkOxOFI>
human HepG2 cells M3jYSmN6fG:2b4jpZ:Kh[XO|YYm= NFzrPXkzPCCq NXfwe3dKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0xNjdizszN NELBTnozOTB7NEC0PS=>
mouse L5178Y cells MYLDfZRwfG:6aXRCpIF{e2G7 Mn\QNlQhcA>? MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDMOVE4QFliY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlczKM7:TR?= Mmf5NlMyQTl2N{m=
human MCF7 cells NUfXdmF{S3m2b4TvfIlkyqCjc4PhfS=> NH3sUXk4OiCq MnHMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgXHRVKGG|c3H5MEBIUTVyPUCuPFYh|ryP NEHLRY4zODV7MU[3PC=>
human MRC5 cells MkW0VJJwdGmoZYLheIlwdiCjc4PhfS=> M3T1NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTWLDOUBk\WyuczygTWM2OD1yLki4JO69VQ>? NYKyO41MOjF3OUmwNFA>
MDA435/LCC6 cells NYDONJFyWHKxbHnm[ZJifGmxbjDhd5NigQ>? NYPHNnBLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBufWy2aXTyeYchemW|aYP0ZY51KE2GQUSzOU9NS0N4IHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvQTd5IN88US=> M1PHW|E4OTV2NUC1
mouse NIH/3T3 cells NYTG[YRLS3m2b4TvfIlkyqCjc4PhfS=> MUO3NkBp NWnFe5o{UW62cnnud4lkKGO7dH;0c5hq[2m2eTDh[4FqdnO2IH3veZNmKE6LSD:zWFMh[2WubIOgc5ZmemW6cILld5NqdmdiTVTSNUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGuNFEh|ryP M2XTUlE5QTV2MESw
human Detroit 551 cells M1Ll[WN6fG:2b4jpZ:Kh[XO|YYm= MYq3NkBp M1TsW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRmfHKxaYSgOVUyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDYWHQh[XO|YYmsJGdKPTB;MT63O{DPxE1? M3z1fVIxPTlzNke4
mouse DA-3 cells NHezU|VEgXSxdH;4bYPDqGG|c3H5 MV6yOEBp NHzx[nJEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBFSS1|IHPlcIx{KGGodHXyJFI1KGi{czDifUBZXFRiYYPzZZktKEmFNUC9NU46KM7:TR?= NGO2VWwzPDlyME[2PC=>
african green monkey Vero cells NUXUcYZ5S3m2b4TvfIlkyqCjc4PhfS=> M{XjWVMh\GG7cx?= MlLzR5l1d3SxeHnjbZR6KGGpYXnud5Qh[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTTJIF{e2G7LDDJR|UxRTJwNTFOwG0> MWGyNVA6PDB2OR?=
Dx5 cell lines M4Tyd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWK1VWh5XGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCGeEWgZ4VtdCCuaX7ld{B2e2mwZzDNWHQh[XO|YYmsJIlkPTB;MjFOwG0> MWGxNFY6QDR2OR?=
human HeLa3 cell line M{f5emN6fG:2b4jpZ:Kh[XO|YYm= MnHQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[TNiY3XscEBtcW6nIHL5JG1VXCCjc4PhfUwhUUN3ME2yMlk3KM7:TR?= NXXvd2xvOTZ7NEKwN|c>
mouse L5178Y cells M4D0XGN6fG:2b4jpZ:Kh[XO|YYm= NIDwZ|MzPCCq M{\hd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGw2OTd6WTDj[YxteyCneIDy[ZN{cW6pIICt[5Ah[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME23Mlc{KM7:TR?= NUL3PJJqOjNzOUm0O|k>
human CRL7761 cells NVvjdJV4S3m2b4TvfIlkyqCjc4PhfS=> NXfkfG9HOyCmYYnz MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDVmw4PzZzIHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFNiYYPzZZktKEmFNUC9NVAvPSEQvF2= M3LFWlIyODl2MES5
human A2780/ADR cells NWC3VJp1S3m2b4TvfIlkyqCjc4PhfS=> NFvGWWM4OiCq MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OC:DRGKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yQC54MkC5JO69VQ>? MVOxO|g6ODB7NB?=
human SKOV3 cells MmPpR5l1d3SxeHnjxsBie3OjeR?= MYGyOEBp NVe3OYluS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFiWVDDhd5NigSxiSVO1NF0zOC54IN88US=> NULY[|BiOjR7MEC2Olg>
human ES2 cells M2LsVGN6fG:2b4jpZ:Kh[XO|YYm= NYj6PJNGOjRiaB?= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFV|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGjUWEBie3OjeTygTWM2OD1{NT61JO69VQ>? MoSwNlQ6ODB4Nki=
CEM cells MYLDfZRwfG:6aXRCpIF{e2G7 MWG3NkBp NXXnXHZmS3m2b4TvfIlkcXS7IHHnZYlve3RiQ1XNJINmdGy|IHHmeIVzKDd{IHjydy=> Mn3LNVc3ODh|OU[=
HOS cells MoP3R5l1d3SxeHnjxsBie3OjeR?= NXrPWW9UPzJiaB?= MULDfZRwfG:6aXPpeJkh[WejaX7zeEBJV1NiY3XscJMh[W[2ZYKgO|IhcHK| Ml6zNVc3ODh|OU[=
mouse DA-3 cells NGnkeY9EgXSxdH;4bYPDqGG|c3H5 Mo\QNlAh|ryP MVK2NEBucW6| NEK2cIpEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBFSS1|IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEAzOCC3TTDh[pRmeiB4MDDtbY5{KGK7IGjUWEBie3OjeR?= NFfPUWozPDlyME[2PC=>
human G361 cells NXvORnJKS3m2b4TvfIlkyqCjc4PhfS=> MX:3NkBp MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHN|YyKGOnbHzzJIFnfGW{IEeyJIhzew>? MXqxO|YxQDN7Nh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / p-ATR / ATR ; 

PubMed: 26727128     


After Caco-2 cells were treated with or without 1 μ M daunorubicin, whole cell extracts were collected at 1, 3, 6, 12, 24, and 48 h and immunoblotted for Chk1, p-Chk1, ATR, and p-ATR. β-actin served as the loading control.

26727128
Immunofluorescence
p-Chk1; 

PubMed: 26727128     


Caco-2 cells were treated with or without 1 μ M daunorubicin for 48 h, and then fixed and stained with anti-p-Chk1 antibody and DAPI. Images were collected under a fluorescence microscope. Scale bar = 10 μm. 

26727128
Growth inhibition assay
Cell viability; 

PubMed: 30745844     


(A) Viability of AML cell lines under different concentrations of Dnr according to the CCK-8 assay. (B) IC50 of AML cell lines calculated according to the result of the CCK-8 assay.

30745844

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (177.31 mM)
Water 100 mg/mL (177.31 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 563.98
Formula

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage powder
in solvent
Synonyms Daunomycin HCl
Smiles CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04562792 Recruiting Drug: Daunorubicin Relapsed Pediatric ALL|Relapsed Pediatric AML|Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City May 8 2020 Phase 2
NCT03878927 Recruiting Drug: CPX-351|Drug: Gemtuzumab Ozogamicin Acute Myeloid Leukemia Weill Medical College of Cornell University|Jazz Pharmaceuticals|Pfizer August 23 2019 Phase 1
NCT03896269 Recruiting Drug: Liposome-encapsulated Daunorubicin-Cytarabine Blasts 10-19 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|High Risk Chronic Myelomonocytic Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory High Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 14 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID