Daunorubicin HCl

Catalog No.S3035 Synonyms: Daunomycin HCl

Daunorubicin HCl Chemical Structure

Molecular Weight(MW): 563.98

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.

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In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
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Cited by 16 Publications

3 Customer Reviews

  • A) MV411 or B) Kasumi 1 cells were incubated with YM155 (0.25 x IC50) in the presence or absence of i) 0.5 x IC50 or ii) 1 x IC50 of Daunorubicin or iii) 0.5 x IC50 or iv) 1 x IC50 of Cytarabine for 72h. Following 72h treatment, cells were subject to a resazurin reduction assay. Percentages were normalised to DMSO controls. Column, mean of 3 independent experiments; Bars, SEM. *p<0.05, **p<0.01, ***p<0.005. Students t-test. Similar trends were observed with 0.5 x and 1 x IC50 of YM155 in combination with Daunorubicin or Cytarabine (data not shown).

    Leuk Res, 2015, 39(4):435-44.. Daunorubicin HCl purchased from Selleck.

  • IL-17A promotes resistance to daunorubicin. Nalm-6 cells and patient B-ALL cells isolated from 4 B-ALL patients were cultured for 24 h in complete medium with or without IL-17A at 50 ng/ml and subsequently supplemented with daunorubicin at 100, 200, or 400 nM as indicated for 24 h. The cell viability was determined using CCK-8 assay, and apoptosis was determined using Annexin V staining. IL-17A promoted the proliferation and reduced apoptosis of Nalm-6 cells (a, c) and patient B-ALL cells (b, d). Statistical data representing at least 3 independent experiments were shown

    J Transl Med, 2016, 14(1):132. Daunorubicin HCl purchased from Selleck.

  • LKB1 downregulation increased the sensitivity of KG1a cells to chemotherapy using cell viability assays. The viability of LKB1 knockdown cells was decreased more significantly compared with control cells after treatment with daunorubicin. *P<0.01, vs LKB1-KD; **P<0.001, vs LKB1-KD.

    Mol Cell Biochem, 2017, 434(1-2):25-32. Daunorubicin HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.
Targets
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
In vitro

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 leukemia cell line NGHwfXpEgXSxdH;4bYPDqGG|c3H5 Mnm2R49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgZ5l1d3SxeHnjbZR6KGGpYXnud5QhWDN6ODDs[ZVs\W2rYTDj[YxtKGyrbnWsJGlEPTB;MzDuUS=> M1zCd|ExPDd7Mkm3
HL60 cells MWfGeY5kfGmxbjDhd5NigQ>? MorITY4hfmm2cn:gbY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RicILvcIln\XKjdHnvckBw\iCKTE[wJINmdGy|LDDJR|UxRTBwMEC1JO69VQ>? MYqxNlg4PzV7Mx?=
human epidermoid carcinoma cell line KB-3-1 MWLDfZRwfG:6aXRCpIF{e2G7 Mn;ZTY4hfmm2cn:gZ5l1d3SxeHnjJIFkfGm4aYT5JJdieyCndnHseYF1\WRidYPpcochfGinIHj1cYFvKGWyaXTldo1wcWRiY3HyZ4lvd22jIHPlcIwhdGmwZTDLRk0{NTFuIFnDOVA:PyCwTR?= NHezbHcyOjR2M{e2Ny=>
human K562 cells MkmxR5l1d3SxeHnjxsBie3OjeR?= M4f6WVczKGh? M3i0bGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHhVXCCjc4PhfUwhT0l3ME23MlQhdk1? NFflXGYzODV7MU[3PC=>
Dx5 w/PSC cell lines NVfm[mxuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjUbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGR5PSC5L2DTR{Bk\WyuIHzpcoV{KHW|aX7nJG1VXCCjc4PhfUwhUUN3ME2xOEBvVQ>? NXLrbG5DOTB4OUi0OFk>
MDA MB 361(mammary carcinoma cell line) M3\1SGN6fG:2b4jpZ:Kh[XO|YYm= MljVWIhmKGOxbYDveY5lKHejczD0[ZN1\WRiZn;yJIlvfHKjY3XscJVt[XJiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgUWRCKE2EIEO2NUhu[W2vYYL5JINiemOrbn;tZUBk\WyuIHzpcoUqKGW6cILld5NqdmdiTHHjXkAp[mW2YT3nZYxi[3Sxc3nkZZNmMSxiSVO1NF0yPyCwTR?= MXixNFM6PTR7MB?=
human MDA-MB-231 cells NWrpN3ZFS3m2b4TvfIlkyqCjc4PhfS=> NUfCZpk{PzJiaB?= NInqRZpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVAvODJizszN NH3WdXAyQTl4OEK1PC=>
MES-SA uterine tumor cell lines NH3N[mRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvFR2JZXGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCPRWOtV2EhfXSncnnu[UB1fW2xcjDj[YxtKGyrbnXzJJV{cW6pIF3UWEBie3OjeTygTWM2OD1yLkCyNUDPxE1? NVXFRVU5OTB4OUi0OFk>
murine L1210 leukemia cells NVnGZ2FnTnWwY4Tpc44h[XO|YYm= NHnzUItKdmirYnn0c5J6KGGldHn2bZR6KHejczDt[YF{fXKnZDDh[4FqdnO2IH31dolv\SCOMUKxNEBt\XWtZX3pZUBk\WyuczygTWM2OD1|MDDuUS=> NXvHR4xEQTd|M{S4Ny=>
HL60 cells MUTGeY5kfGmxbjDhd5NigQ>? MnjNTY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcoR2[2ViYYDvdJRwe2m|IHnuJGhNPjBiY3XscJMtKEGFNUC9NE4xPCEQvF2= MoCzNVI5Pzd3OUO=
CCRF-CEM (human lymphoblastic leukemic) cells Ml[yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MofSTY4hfmm2cn:g[5Jwf3SqIHnubIljcXSxcomgZYN1cX[rdImgZYdicW6|dDDDR3JHNUOHTTCobJVu[W5ibIntdIhw[myjc4TpZ{Bt\XWtZX3pZ{kh[2WubIOsJGlFPTB;MD6wOEDPxE1? MUW2PVUyODR7
mouse NIH/3T3 cells Mm\4R5l1d3SxeHnjxsBie3OjeR?= NXjVRXg1PzJiaB?= MnH0TY51emmwc3njJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHerbHSgeJlx\SCvb4Xz[UBPUUhxM2SzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yNESg{txO MlO3NVg6PTRyNEC=
human prostate cancer HTB-81 cells M4X3[WN6fG:2b4jpZ:Kh[XO|YYm= NWf0SpJtS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDoeY1idiCycn;zeIF1\SClYX7j[ZIhUFSELUixJINmdGy|IIXzbY5oKE2WUzDhd5NigSxiRVO1NF0xNjB3ODFOwG0> M4HmPFEyODJyMki1
human breast carcinoma line cells MoXUSpVv[3Srb36gZZN{[Xl? MnLPZ49ueG:3bnSge4F{KHSnc4Tl[EBqdiC4aYTyc{Bnd3JiaX7obYJqfGmxbjDhZ5Rqfmm2eTDh[4FqdnO2IHGgd4Vve2m2aY\lJIh2dWGwIHLy[YF{fCClYYLjbY5wdWFibHnu[UBk\WyuczygTWM2OD1yLkC2JO69VQ>? MkHKPVI2QDN3MR?=
MCF-7 cells Mo\JR5l1d3SxeHnjxsBie3OjeR?= MYHDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCrdIOgeI95cWOrdImgZYdicW6|dDDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGy|KF3DSk04MSxiSVO1NF0xNjB4IN88US=> M1vYW|k2PDh6MkC=
human HT-29 cells NEnZeZNEgXSxdH;4bYPDqGG|c3H5 MlXPO|IhcA>? NXv6NpA1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;MD6wO{DPxE1? MXKxPVk3QDJ3OB?=
human uterine sarcoma cell line MES-SA NInYW|lEgXSxdH;4bYPDqGG|c3H5 NHjqTJZKdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5idYTldolv\SC|YYLjc41iKGOnbHygcIlv\SCPRWOtV2EtKEmFNUC9NE4xPyEQvF2= MWSxNlQ1Ozd4Mx?=
human MRC5 cells M2D3dXBzd2yrZnXyZZRqd25iYYPzZZk> MorrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPUlO1JINmdGy|IHL5JHhVXCCjc4PhfUwhUUN3ME2wMlA4QCEQvF2= NXLF[|NPOjV2NkeyPVE>
MDA435/LCC6 cells M{Xa[HBzd2yrZnXyZZRqd25iYYPzZZk> MnfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDNSGE1OzVxTFPDOkBk\WyuczDifUBGVEmVQTygTWM2OD1yLkC3PUDPxE1? MmLHNVcyPTR3MEW=
human A549 cells NEjZToNEgXSxdH;4bYPDqGG|c3H5 NVTuRZcxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OD1yLkC4JO69VQ>? MXixPVk3QDJ3OB?=
Jurkat T lymphocytes M3flVWN6fG:2b4jpZ:Kh[XO|YYm= MoXJR5l1d3SxeHnjbZR6KGGpYXnud5QhUnW{a3H0JHQhdHmvcHjvZ5l1\XNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFgzPiEQvF2= MWSxOlM3PjZyMh?=
human DU145 cells MU\Qdo9tcW[ncnH0bY9vKGG|c3H5 NF:3fYk4OiCq MorTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTBwMEmg{txO M2nWWVIzOjZyMU[2
human MDA-MB-231 cells NX7VTZQ3WHKxbHnm[ZJifGmxbjDhd5NigQ>? Mk[1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IGjUWEBie3OjeTygTWM2OD1yLkC5NUDPxE1? MXWyOVQ3PzJ7MR?=
human H1299 cells NXPyVY13WHKxbHnm[ZJifGmxbjDhd5NigQ>? NFXzeXJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFixNlk6KGOnbHzzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjB7NjFOwG0> MmToNlU1Pjd{OUG=
human HL60 cells MY\DfZRwfG:6aXRCpIF{e2G7 NEPVVWc1QCCq MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUB1enmyYX6gZox2\SC|dHHpcolv\y2kYYPl[EBp\W2xY4n0c41mfHKrYzDhcoFtgXOrczygS2k2OD1yLkGg{txO NYPNWWN[OjV6N{SzN|U>
human LNCAP cells Ml\XR5l1d3SxeHnjxsBie3OjeR?= NFe3cZg1KGSjeYO= Ml7DR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6xJO69VQ>? NGPUe20zOjR6MES5OS=>
NCI-H69 cell line Mor6VJJwdGmoZYLheIlwdiCjc4PhfS=> NWPnPYpqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpIIPlcpNqfGm4ZTDOR2kuUDZ7IHPlcIwhdGmwZTDifUBCdGGvYYKgRox2\SCjc4PhfUwhUUN3ME2wMlEh|ryP MlfLNVczQDZ|OUO=
human A2780 cells NXP4TVZmS3m2b4TvfIlkyqCjc4PhfS=> MUe3NkBp MnjIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlEyPzR7IN88US=> MVSxO|g6ODB7NB?=
human HT-29 cells NULFdJlLWHKxbHnm[ZJifGmxbjDhd5NigQ>? NELaeVA6PiCq NVHwN4MxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNVM{KM7:TR?= NEXYXnYzPzd6NES5
B16 mouse melanoma cells MmL4R5l1d3SxeHnjxsBie3OjeR?= NELpWodEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIFKxOkBud3W|ZTDt[Yxidm:vYTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUC9NE4yPiEQvF2= MnO1NVExOjB{OEW=
human SKMES1 cells NXjDc3VpWHKxbHnm[ZJifGmxbjDhd5NigQ>? NVTpbIN4PzJiaB?= M2n5[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vNSXMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MD6xO{DPxE1? NHLHcFQzOjJ4MEG2Oi=>
human fibroblast (NHF) cells MWnDfZRwfG:6aXRCpIF{e2G7 MUXDfZRwfG:6aXPpeJkhfGijdDDjZZV{\WRiYTC1NEUhemWmdXP0bY9vKGmwIHHid49z[mGwY3WgZZQhPDlyIH7tJIlvKG6xcn3hcEBpfW2jbjDmbYJzd2KuYYP0JEhPUEZrIHPlcIx{KHW|aX7nJG1VWyCjc4PhfUwhTUN3ME2wMlIzKM7:TR?= MWqxNVAzODJ6NR?=
mouse L1210 cells MmXESpVv[3Srb36gZZN{[Xl? MmXRTY5pcWKrdHnvckBw\iCUTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{NCCHREWwQVAvOjNizszN M1f4XlY6ODl7OR?=
human NCI-H460 cells MYXGeY5kfGmxbjDhd5NigQ>? M33lPGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyxiSVO1NF0xNjN6IN88US=> NELzTJMzOTV7OUCwNC=>
human MCF7 cells MlvYR5l1d3SxeHnjxsBie3OjeR?= MWS0JIRigXN? MmixR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1yLkSg{txO NFS4Z5IzOjR6MES5OS=>
human SF268 cells MkfVSpVv[3Srb36gZZN{[Xl? NEPCeZJCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2YzPjhiY3XscJMtKEmFNUC9NE43KM7:TR?= MVyyNVU6QTByMB?=
human KB cells MlvBR5l1d3SxeHnjxsBie3OjeR?= NVzMS|N6PDhiaB?= Mn3RR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[0JO69VQ>? NGG0U4QzODN4M{G0Ni=>
human HepG2 cells M1j0S2N6fG:2b4jpZ:Kh[XO|YYm= NUfid5BJOjRiaB?= MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUCuO{DPxE1? NGfMSWQzOTB7NEC0PS=>
mouse L5178Y cells M3zNPGN6fG:2b4jpZ:Kh[XO|YYm= NV3LUINIOjRiaB?= NHHrOmJEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBNPTF5OGmgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjd{IN88US=> NWOy[WhSOjNzOUm0O|k>
human MCF7 cells MXnDfZRwfG:6aXRCpIF{e2G7 MoTtO|IhcA>? NWnzTpN7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhYFSWIHHzd4F6NCCJSUWwQVAvQDZizszN NXvucVhsOjB3OUG2O|g>
human MRC5 cells NF7lOWNRem:uaX\ldoF1cW:wIHHzd4F6 NVHjV3prSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzMEBKSzVyPUCuPFgh|ryP MnPwNlE2QTlyMEC=
MDA435/LCC6 cells M{TKRnBzd2yrZnXyZZRqd25iYYPzZZk> MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH31cJRq\HK3ZzDy[ZNqe3SjboSgUWRCPDN3L1zDR|Yh[2WubIOgZpkhTUyLU1GsJGlEPTB;MD65O|ch|ryP NUjNZmxkOTdzNUS1NFU>
mouse NIH/3T3 cells NWnDRmhVS3m2b4TvfIlkyqCjc4PhfS=> NF61fG44OiCq NFjidHBKdnS{aX7zbYMh[3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDveoVz\XiycnXzd4lv\yCPRGKxJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6wNUDPxE1? NF\2dlkyQDl3NEC0NC=>
human Detroit 551 cells NVTLR3NWS3m2b4TvfIlkyqCjc4PhfS=> MoTOO|IhcA>? MlnQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSIV1em:rdDC1OVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGjUWEBie3OjeTygS2k2OD1zLke3JO69VQ>? NILQenIzODV7MU[3PC=>
mouse DA-3 cells Mn3LR5l1d3SxeHnjxsBie3OjeR?= NF7xVnAzPCCq M4THVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGRCNTNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHhVXCCjc4PhfUwhUUN3ME2xMlkh|ryP NFP5SlUzPDlyME[2PC=>
african green monkey Vero cells Mon0R5l1d3SxeHnjxsBie3OjeR?= NFLBcWc{KGSjeYO= NE\hZ4ZEgXSxdH;4bYNqfHliYXfhbY5{fCCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHMh[XO|YYmsJGlEPTB;Mj61JO69VQ>? NYjkVIFsOjFyOUSwOFk>
Dx5 cell lines NYXQcJNtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\DWIhmKGOxbYDveY5lKHejczDleoFtfWG2ZXSg[o9zKHSqZTDndo94fGhiaX7obYJqfGmxbjDv[kBFgDViY3XscEBtcW6nczD1d4lv\yCPVGSgZZN{[XluIHnjOVA:OiEQvF2= M3zaUFExPjl6NES5
human HeLa3 cell line Mn;SR5l1d3SxeHnjxsBie3OjeR?= M2PHTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGF|IHPlcIwhdGmwZTDifUBOXFRiYYPzZZktKEmFNUC9Nk46PiEQvF2= NVSzcFd7OTZ7NEKwN|c>
mouse L5178Y cells NFXOdohEgXSxdH;4bYPDqGG|c3H5 M1fBSVI1KGh? M{POXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGw2OTd6WTDj[YxteyCneIDy[ZN{cW6pIICt[5Ah[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME23Mlc{KM7:TR?= MXiyN|E6QTR5OR?=
human CRL7761 cells MWPDfZRwfG:6aXRCpIF{e2G7 NWewVYhGOyCmYYnz MnHjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR3JNPzd4MTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSVIHHzd4F6NCCLQ{WwQVExNjVizszN MljDNlExQTRyNEm=
human A2780/ADR cells NIHoUVJEgXSxdH;4bYPDqGG|c3H5 M2r5O|czKGh? MoTCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBxQVTSJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OThwNkKwPUDPxE1? NUPLU4dkOTd6OUCwPVQ>
human SKOV3 cells MUjDfZRwfG:6aXRCpIF{e2G7 NHHqfJozPCCq NHvGNHJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwQVIxNjZizszN M1TzUlI1QTByNk[4
human ES2 cells MYXDfZRwfG:6aXRCpIF{e2G7 NVnzb25HOjRiaB?= NXezU|RvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTVN{IHPlcIx{KGGodHXyJFI1KGi{czDifUBZXFRiYYPzZZktKEmFNUC9NlUvPSEQvF2= MYCyOFkxODZ4OB?=
CEM cells M2W5UmN6fG:2b4jpZ:Kh[XO|YYm= MXq3NkBp MonhR5l1d3SxeHnjbZR6KGGpYXnud5QhS0WPIHPlcIx{KGGodHXyJFczKGi{cx?= M3zqUVE4PjB6M{m2
HOS cells M3\4emN6fG:2b4jpZ:Kh[XO|YYm= NVnOUnRTPzJiaB?= NFHT[GNEgXSxdH;4bYNqfHliYXfhbY5{fCCKT2OgZ4VtdHNiYX\0[ZIhPzJiaILz M4DkPVE4PjB6M{m2
mouse DA-3 cells MXrDfZRwfG:6aXRCpIF{e2G7 NHfido8zOCEQvF2= NESzem43OCCvaX7z MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDERU0{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDCyNEB2VSCjZoTldkA3OCCvaX7zJIJ6KFiWVDDhd5NigQ>? M3XOSFI1QTByNk[4
human G361 cells NHXweI1EgXSxdH;4bYPDqGG|c3H5 MWW3NkBp M4Dxb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGc{PjFiY3XscJMh[W[2ZYKgO|IhcHK| MYGxO|YxQDN7Nh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (177.31 mM)
Water 100 mg/mL (177.31 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 563.98
Formula

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage powder
in solvent
Synonyms Daunomycin HCl

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03836209 Not yet recruiting Acute Myeloid Leukemia PrECOG LLC.|Astellas Pharma Inc July 2019 Phase 2
NCT03836209 Not yet recruiting Acute Myeloid Leukemia PrECOG LLC.|Astellas Pharma Inc July 2019 Phase 2
NCT03825796 Not yet recruiting Blasts 5 Percent or More of Bone Marrow Nucleated Cells|IDH2 Gene Mutation|Recurrent Acute Myeloid Leukemia Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) March 1 2019 Phase 2
NCT03860844 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia Sanofi March 11 2019 Phase 2
NCT03860844 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia Sanofi March 11 2019 Phase 2
NCT03850535 Recruiting Acute Myeloid Leukemia Hoffmann-La Roche March 16 2019 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID