Daunorubicin HCl

Catalog No.S3035 Synonyms: Daunomycin HCl

Daunorubicin HCl Chemical Structure

Molecular Weight(MW): 563.98

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.

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In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
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Cited by 16 Publications

3 Customer Reviews

  • A) MV411 or B) Kasumi 1 cells were incubated with YM155 (0.25 x IC50) in the presence or absence of i) 0.5 x IC50 or ii) 1 x IC50 of Daunorubicin or iii) 0.5 x IC50 or iv) 1 x IC50 of Cytarabine for 72h. Following 72h treatment, cells were subject to a resazurin reduction assay. Percentages were normalised to DMSO controls. Column, mean of 3 independent experiments; Bars, SEM. *p<0.05, **p<0.01, ***p<0.005. Students t-test. Similar trends were observed with 0.5 x and 1 x IC50 of YM155 in combination with Daunorubicin or Cytarabine (data not shown).

    Leuk Res, 2015, 39(4):435-44.. Daunorubicin HCl purchased from Selleck.

  • IL-17A promotes resistance to daunorubicin. Nalm-6 cells and patient B-ALL cells isolated from 4 B-ALL patients were cultured for 24 h in complete medium with or without IL-17A at 50 ng/ml and subsequently supplemented with daunorubicin at 100, 200, or 400 nM as indicated for 24 h. The cell viability was determined using CCK-8 assay, and apoptosis was determined using Annexin V staining. IL-17A promoted the proliferation and reduced apoptosis of Nalm-6 cells (a, c) and patient B-ALL cells (b, d). Statistical data representing at least 3 independent experiments were shown

    J Transl Med, 2016, 14(1):132. Daunorubicin HCl purchased from Selleck.

  • LKB1 downregulation increased the sensitivity of KG1a cells to chemotherapy using cell viability assays. The viability of LKB1 knockdown cells was decreased more significantly compared with control cells after treatment with daunorubicin. *P<0.01, vs LKB1-KD; **P<0.001, vs LKB1-KD.

    Mol Cell Biochem, 2017, 434(1-2):25-32. Daunorubicin HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.
Targets
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
In vitro

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 leukemia cell line MlvJR5l1d3SxeHnjxsBie3OjeR?= MkDKR49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgZ5l1d3SxeHnjbZR6KGGpYXnud5QhWDN6ODDs[ZVs\W2rYTDj[YxtKGyrbnWsJGlEPTB;MzDuUS=> MU[xNFQ4QTJ7Nx?=
HL60 cells NYHYN3EzTnWwY4Tpc44h[XO|YYm= NVXLb|hvUW5idnn0do8hcW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgdJJwdGmoZYLheIlwdiCxZjDIUFYxKGOnbHzzMEBKSzVyPUCuNFA2KM7:TR?= NWj1RphTOTJ6N{e1PVM>
human epidermoid carcinoma cell line KB-3-1 NXvPVllGS3m2b4TvfIlkyqCjc4PhfS=> NFz1flRKdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5iZYDp[IVzdW:rZDDjZZJkcW6xbXGgZ4VtdCCuaX7lJGtDNTNvMTygTWM2OD15IH7N MU[xNlQ1Ozd4Mx?=
human K562 cells MUDDfZRwfG:6aXRCpIF{e2G7 M3nUZVczKGh? NELwbZJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBZXFRiYYPzZZktKEeLNUC9O{41KG6P NWDOR2xFOjB3OUG2O|g>
Dx5 w/PSC cell lines MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHrlOolVcGViY3;tdI92dmRid3HzJIV3[Wy3YYTl[EBnd3JidHjlJIdzd3e2aDDpcohq[mm2aX;uJI9nKES6NTD3M3BUSyClZXzsJIxqdmW|IIXzbY5oKE2WVDDhd5NigSxiSVO1NF0yPCCwTR?= NEjJdIIyODZ7OES0PS=>
MDA MB 361(mammary carcinoma cell line) MljNR5l1d3SxeHnjxsBie3OjeR?= NFviUpVVcGViY3;tdI92dmRid3HzJJRme3SnZDDmc5IhcW62cnHj[YxtfWyjcjDjfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFiTVKgN|YyMG2jbX3hdpkh[2G{Y3nuc41iKGOnbHygcIlv\SliZYjwdoV{e2mwZzDMZYNbKCikZYThMYdidGGldH;zbYRie2VrLDDJR|UxRTF5IH7N MkO0NVA{QTV2OUC=
human MDA-MB-231 cells NXqx[HRzS3m2b4TvfIlkyqCjc4PhfS=> Mne5O|IhcA>? MmfhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME2wMlAzKM7:TR?= NG[2NncyQTl4OEK1PC=>
MES-SA uterine tumor cell lines M4fpRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoC3WIhmKGOxbYDveY5lKHejczDleoFtfWG2ZXSg[o9zKHSqZTDndo94fGhiaX7obYJqfGmxbjDv[kBOTVNvU1GgeZRmemmwZTD0eY1weiClZXzsJIxqdmW|IIXzbY5oKE2WVDDhd5NigSxiSVO1NF0xNjB{MTFOwG0> NEX0W2oyODZ7OES0PS=>
murine L1210 leukemia cells M2nCbmZ2dmO2aX;uJIF{e2G7 MmfrTY5pcWKrdH;yfUBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYXfhbY5{fCCvdYLpcoUhVDF{MUCgcIV2c2WvaXGgZ4VtdHNuIFnDOVA:OzBibl2= M2LqZlk4OzN2OEO=
HL60 cells NVPPVZdnTnWwY4Tpc44h[XO|YYm= MX\JckB3cXS{bzDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnu[JVk\SCjcH;weI9{cXNiaX6gTGw3OCClZXzsd{whSUN3ME2wMlA1KM7:TR?= MYexNlg4PzV7Mx?=
CCRF-CEM (human lymphoblastic leukemic) cells MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVjWNHBDUW5idnn0do8h\3Kxd4ToJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBES1KILVPFUUApcHWvYX6gcJlueGixYnzhd5Rq[yCuZYXr[Y1q[yliY3XscJMtKEmGNUC9NE4xPCEQvF2= MVG2PVUyODR7
mouse NIH/3T3 cells NHrBe49EgXSxdH;4bYPDqGG|c3H5 MoLLO|IhcA>? NYixS4p4UW62cnnud4lkKGO7dH;0c5hq[2m2eTDh[4FqdnO2IIfpcIQhfHmyZTDtc5V{\SCQSVivN3Q{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wOFQh|ryP NVL6fpBYOTh7NUSwOFA>
human prostate cancer HTB-81 cells M3XSWmN6fG:2b4jpZ:Kh[XO|YYm= MXLDfZRwfG:6aXPpeJkhfGijdDDjZZV{\WRiYTC1NEUhemWmdXP0bY9vKGmwIHHid49z[mGwY3WgZZQhPDlyIH7tJIlvKGi3bXHuJJBzd3O2YYTlJINidmOncjDIWGIuQDFiY3XscJMhfXOrbnegUXRUKGG|c3H5MEBGSzVyPUCuNFU5KM7:TR?= MVOxNVAzODJ6NR?=
human breast carcinoma line cells M4j3SmZ2dmO2aX;uJIF{e2G7 MofHZ49ueG:3bnSge4F{KHSnc4Tl[EBqdiC4aYTyc{Bnd3JiaX7obYJqfGmxbjDhZ5Rqfmm2eTDh[4FqdnO2IHGgd4Vve2m2aY\lJIh2dWGwIHLy[YF{fCClYYLjbY5wdWFibHnu[UBk\WyuczygTWM2OD1yLkC2JO69VQ>? NHHnd4w6OjV6M{Wx
MCF-7 cells NUPt[HdMS3m2b4TvfIlkyqCjc4PhfS=> NEnEb4xEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDpeJMhfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzLG1ETi15KTygTWM2OD1yLkC2JO69VQ>? NFfqVWc6PTR6OEKw
human HT-29 cells MkizR5l1d3SxeHnjxsBie3OjeR?= MUC3NkBp NVOyW21NS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;MD6wO{DPxE1? MkW2NVk6Pjh{NUi=
human uterine sarcoma cell line MES-SA NV3RNGJtS3m2b4TvfIlkyqCjc4PhfS=> NWnCWopvUW5idnn0do8h[3m2b4TvfIlkKGGldHn2bZR6KHejczDleoFtfWG2ZXSgeZNqdmdidHjlJIh2dWGwIIX0[ZJqdmVic3HyZ49u[SClZXzsJIxqdmViTVXTMXNCNCCLQ{WwQVAvODdizszN MnfaNVI1PDN5NkO=
human MRC5 cells MUjQdo9tcW[ncnH0bY9vKGG|c3H5 NXPZO5JCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjB5ODFOwG0> MXGyOVQ3PzJ7MR?=
MDA435/LCC6 cells M2fpb3Bzd2yrZnXyZZRqd25iYYPzZZk> NEntWoVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JG1FSTR|NT;MR2M3KGOnbHzzJIJ6KEWOSWPBMEBKSzVyPUCuNFc6KM7:TR?= NVT5WIxuOTdzNUS1NFU>
human A549 cells Mlv1R5l1d3SxeHnjxsBie3OjeR?= NHHmdY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTBwMEig{txO MX:xPVk3QDJ3OB?=
Jurkat T lymphocytes MmnjR5l1d3SxeHnjxsBie3OjeR?= MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBLfXKtYYSgWEBtgW2yaH;jfZRmeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wPFI3KM7:TR?= NELIeYYyPjN4Nk[wNi=>
human DU145 cells MmPGVJJwdGmoZYLheIlwdiCjc4PhfS=> Mn7lO|IhcA>? M2PSZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1yLkC5JO69VQ>? NICzSXgzOjJ4MEG2Oi=>
human MDA-MB-231 cells NVjqRmU3WHKxbHnm[ZJifGmxbjDhd5NigQ>? M2LxT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDYWHQh[XO|YYmsJGlEPTB;MD6wPVEh|ryP NIj2OmgzPTR4N{K5NS=>
human H1299 cells NYnFSJBKWHKxbHnm[ZJifGmxbjDhd5NigQ>? NXTDUpJLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDINVI6QSClZXzsd{BjgSC[VGSgZZN{[XluIFnDOVA:OC5yOU[g{txO M3TsNlI2PDZ5Mkmx
human HL60 cells MlvXR5l1d3SxeHnjxsBie3OjeR?= MoDvOFghcA>? NICyU5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSC2conwZY4h[my3ZTDzeIFqdmmwZz3iZZNm\CCqZX3vZ5l1d22ndILpZ{BidmGueYPpd{whT0l3ME2wMlEh|ryP NWfmc45wOjV6N{SzN|U>
human LNCAP cells MX\DfZRwfG:6aXRCpIF{e2G7 NG\t[Hk1KGSjeYO= NU[1XHczS3m2b4P0ZZRq[yCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGxPS0GSIHPlcIx{KGGodHXyJFQh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE4yKM7:TR?= NUPsSpdUOjJ2OEC0PVU>
NCI-H69 cell line M{jvbnBzd2yrZnXyZZRqd25iYYPzZZk> NW\tUm1vSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpIIPlcpNqfGm4ZTDOR2kuUDZ7IHPlcIwhdGmwZTDifUBCdGGvYYKgRox2\SCjc4PhfUwhUUN3ME2wMlEh|ryP M3;lSVE4Ojh4M{mz
human A2780 cells NHTYXZBEgXSxdH;4bYPDqGG|c3H5 Ml\jO|IhcA>? M2TWdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4yOTd2OTFOwG0> M3LUOlE4QDlyMEm0
human HT-29 cells MYXQdo9tcW[ncnH0bY9vKGG|c3H5 NXnJb2xXQTZiaB?= MniyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwMUOzJO69VQ>? Mn3JNlc4QDR2OR?=
B16 mouse melanoma cells M3\veWN6fG:2b4jpZ:Kh[XO|YYm= NICwemdEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIFKxOkBud3W|ZTDt[Yxidm:vYTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUC9NE4yPiEQvF2= M4LHfVEyODJyMki1
human SKMES1 cells MXXQdo9tcW[ncnH0bY9vKGG|c3H5 M1zlb|czKGh? M4G0N2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vNSXMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MD6xO{DPxE1? MXKyNlI3ODF4Nh?=
human fibroblast (NHF) cells NWrLZ5NnS3m2b4TvfIlkyqCjc4PhfS=> M3;LUmN6fG:2b4jpZ4l1gSC2aHH0JINifXOnZDDhJFUxLSC{ZXT1Z5Rqd25iaX6gZYJ{d3KkYX7j[UBifCB2OUCgco0hcW5ibn;ycYFtKGi3bXHuJIZq[nKxYnzhd5QhME6KRjmgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwQVAvOjJizszN MVmxNVAzODJ6NR?=
mouse L1210 cells MlLxSpVv[3Srb36gZZN{[Xl? MmXYTY5pcWKrdHnvckBw\iCUTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{NCCHREWwQVAvOjNizszN MV:2PVA6QTl?
human NCI-H460 cells M{XtSWZ2dmO2aX;uJIF{e2G7 NEjLS|FCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNuIFnDOVA:OC5|ODFOwG0> NWjmWWE2OjF3OUmwNFA>
human MCF7 cells MnnQR5l1d3SxeHnjxsBie3OjeR?= M3;Kb|Qh\GG7cx?= MUXDfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNDFOwG0> NYfVcGpJOjJ2OEC0PVU>
human SF268 cells MXjGeY5kfGmxbjDhd5NigQ>? M{ThXmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTSlI3QCClZXzsd{whUUN3ME2wMlYh|ryP NYnVem8{OjF3OUmwNFA>
human KB cells M2i3OGN6fG:2b4jpZ:Kh[XO|YYm= MkfaOFghcA>? NEHuSm5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOlQh|ryP NXrKTlhmOjB|NkOxOFI>
human HepG2 cells NFnnXWFEgXSxdH;4bYPDqGG|c3H5 M1fMPFI1KGh? M1vKbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NE44KM7:TR?= NXuzfohVOjFyOUSwOFk>
mouse L5178Y cells MYjDfZRwfG:6aXRCpIF{e2G7 M{OwblI1KGh? NGLyPY9EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBNPTF5OGmgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjd{IN88US=> NEHw[2gzOzF7OUS3PS=>
human MCF7 cells MkT3R5l1d3SxeHnjxsBie3OjeR?= NWmzV20{PzJiaB?= MnTpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgXHRVKGG|c3H5MEBIUTVyPUCuPFYh|ryP MonoNlA2QTF4N{i=
human MRC5 cells NVXNfnJ{WHKxbHnm[ZJifGmxbjDhd5NigQ>? NXnado9DSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzMEBKSzVyPUCuPFgh|ryP MWiyNVU6QTByMB?=
MDA435/LCC6 cells NHftZ2NRem:uaX\ldoF1cW:wIHHzd4F6 NHntbHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI12dHSrZIL1[{Bz\XOrc4ThcpQhVUSDNEO1M2xESzZiY3XscJMh[nliRVzJV2EtKEmFNUC9NE46PzdizszN MX2xO|E2PDVyNR?=
mouse NIH/3T3 cells NHOwdnREgXSxdH;4bYPDqGG|c3H5 MknHO|IhcA>? NFXVXmJKdnS{aX7zbYMh[3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDveoVz\XiycnXzd4lv\yCPRGKxJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6wNUDPxE1? NUj4ZXVuOTh7NUSwOFA>
human Detroit 551 cells M4D5dmN6fG:2b4jpZ:Kh[XO|YYm= NEfPU4g4OiCq NF3Kd2FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBF\XS{b3n0JFU2OSClZXzsd{Bi\nSncjC3NkBpenNiYomgXHRVKGG|c3H5MEBIUTVyPUGuO|ch|ryP NVHNWWZ1OjB3OUG2O|g>
mouse DA-3 cells MmLQR5l1d3SxeHnjxsBie3OjeR?= NF;CW|QzPCCq MlLHR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgSGEuOyClZXzsd{Bi\nSncjCyOEBpenNiYomgXHRVKGG|c3H5MEBKSzVyPUGuPUDPxE1? M1mxUFI1QTByNk[4
african green monkey Vero cells NHXTXmFEgXSxdH;4bYPDqGG|c3H5 NH7EeVY{KGSjeYO= NFHKfIpEgXSxdH;4bYNqfHliYXfhbY5{fCCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHMh[XO|YYmsJGlEPTB;Mj61JO69VQ>? NYrxVHBNOjFyOUSwOFk>
Dx5 cell lines NFrZTGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULXTZhQXGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCGeEWgZ4VtdCCuaX7ld{B2e2mwZzDNWHQh[XO|YYmsJIlkPTB;MjFOwG0> NVzlXmZiOTB4OUi0OFk>
human HeLa3 cell line MXjDfZRwfG:6aXRCpIF{e2G7 M{TMcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGF|IHPlcIwhdGmwZTDifUBOXFRiYYPzZZktKEmFNUC9Nk46PiEQvF2= Mn63NVY6PDJyM{e=
mouse L5178Y cells MmrER5l1d3SxeHnjxsBie3OjeR?= NITSSGEzPCCq MlLXR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFUyPzi\IHPlcIx{KGW6cILld5NqdmdicD3ndEBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUeuO|Mh|ryP NUPsTnhJOjNzOUm0O|k>
human CRL7761 cells M1HjSmN6fG:2b4jpZ:Kh[XO|YYm= NFvkRlE{KGSjeYO= MmPYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR3JNPzd4MTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSVIHHzd4F6NCCLQ{WwQVExNjVizszN M2fpOFIyODl2MES5
human A2780/ADR cells MUfDfZRwfG:6aXRCpIF{e2G7 NEDUT204OiCq NGfaTnREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjd6MD;BSHIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zOD62NlA6KM7:TR?= MYGxO|g6ODB7NB?=
human SKOV3 cells NUjRNmhkS3m2b4TvfIlkyqCjc4PhfS=> M4rmTFI1KGh? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{Bi\nSncjCyOEBpenNiYomgXHRVKGG|c3H5MEBKSzVyPUKwMlYh|ryP MoHMNlQ6ODB4Nki=
human ES2 cells M{LFU2N6fG:2b4jpZ:Kh[XO|YYm= MYiyOEBp MlixR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSXMzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDYWHQh[XO|YYmsJGlEPTB;MkWuOUDPxE1? NXPj[49ZOjR7MEC2Olg>
CEM cells MnnlR5l1d3SxeHnjxsBie3OjeR?= NW[3ZYVFPzJiaB?= NYfGb3lKS3m2b4TvfIlkcXS7IHHnZYlve3RiQ1XNJINmdGy|IHHmeIVzKDd{IHjydy=> MYGxO|YxQDN7Nh?=
HOS cells MmPkR5l1d3SxeHnjxsBie3OjeR?= NFzzVZM4OiCq Mn;TR5l1d3SxeHnjbZR6KGGpYXnud5QhUE:VIHPlcIx{KGGodHXyJFczKGi{cx?= NWf2fZM1OTd4MEizPVY>
mouse DA-3 cells Mlj5R5l1d3SxeHnjxsBie3OjeR?= MWKyNEDPxE1? M{L1PFYxKG2rboO= NU\jdFFHS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhTEFvMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhOjBidV2gZYZ1\XJiNkCgcYlveyCkeTDYWHQh[XO|YYm= NGTU[JUzPDlyME[2PC=>
human G361 cells NXXyem1yS3m2b4TvfIlkyqCjc4PhfS=> MnyxO|IhcA>? M2LaSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGc{PjFiY3XscJMh[W[2ZYKgO|IhcHK| NVTZVI42OTd4MEizPVY>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (177.31 mM)
Water 100 mg/mL (177.31 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 563.98
Formula

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage powder
in solvent
Synonyms Daunomycin HCl

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03836209 Not yet recruiting Acute Myeloid Leukemia PrECOG LLC.|Astellas Pharma Inc July 2019 Phase 2
NCT03836209 Not yet recruiting Acute Myeloid Leukemia PrECOG LLC.|Astellas Pharma Inc July 2019 Phase 2
NCT03825796 Not yet recruiting Blasts 5 Percent or More of Bone Marrow Nucleated Cells|IDH2 Gene Mutation|Recurrent Acute Myeloid Leukemia Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) March 1 2019 Phase 2
NCT03860844 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia Sanofi March 11 2019 Phase 2
NCT03860844 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia Sanofi March 11 2019 Phase 2
NCT03850535 Recruiting Acute Myeloid Leukemia Hoffmann-La Roche March 16 2019 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID