Daunorubicin (RP 13057) HCl

Catalog No.S3035 Synonyms: Daunomycin HCl, Rubidomycin HCl

For research use only.

Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

Daunorubicin (RP 13057) HCl Chemical Structure

CAS No. 23541-50-6

Selleck's Daunorubicin (RP 13057) HCl has been cited by 48 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
Targets
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
In vitro

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA MB 361(mammary carcinoma cell line) NYntcJRQS3m2b4TvfIlkyqCjc4PhfS=> M2GwVXRp\SClb33wc5Vv\CC5YYOgeIV{fGWmIH\vdkBqdnS{YXPlcIx2dGG{IHP5eI91d3irY3n0fUBi\2GrboP0JG1FSSCPQjCzOlEpdWGvbXHyfUBk[XKlaX7vcYEh[2WubDDsbY5mMSCneIDy[ZN{cW6pIFzhZ3ohMGKndHGt[4Ft[WO2b4Pp[IF{\SluIFnDOVA:OTdibl2= NGKydZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEO5OVQ6OCd-MUCzPVU1QTB:L3G+
P388 leukemia cell line NIH5ZYpEgXSxdH;4bYPDqGG|c3H5 NH[3RlNEd22yb4Xu[EB4[XNiZY\hcJVifGWmIH\vdkBkgXSxdH;4bYNqfHliYXfhbY5{fCCSM{i4JIxmfWunbXnhJINmdGxibHnu[UwhUUN3ME2zJI5O Mln2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2N{myPVcoRjFyNEe5Nlk4RC:jPh?=
Dx5 w/PSC cell lines NVv5NJVMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfUbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGR5PSC5L2DTR{Bk\WyuIHzpcoV{KHW|aX7nJG1VXCCjc4PhfUwhUUN3ME2xOEBvVQ>? NYrhe29iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC2PVg1PDlpPkGwOlk5PDR7PD;hQi=>
MES-SA uterine tumor cell lines MojMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2izU3Rp\SClb33wc5Vv\CC5YYOg[ZZidHWjdHXkJIZweiC2aHWg[5Jwf3SqIHnubIljcXSrb36gc4YhVUWVLWPBJJV1\XKrbnWgeJVud3JiY3XscEBtcW6nczD1d4lv\yCPVGSgZZN{[XluIFnDOVA:OC5yMkGg{txO MoSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB4OUi0OFkoRjFyNkm4OFQ6RC:jPh?=
Dx5 cell lines NHTJd2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvObYU4XGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCGeEWgZ4VtdCCuaX7ld{B2e2mwZzDNWHQh[XO|YYmsJIlkPTB;MjFOwG0> M3rzelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNkm4OFQ6Lz5zME[5PFQ1QTxxYU6=
human epidermoid carcinoma cell line KB-3-1 MXLDfZRwfG:6aXRCpIF{e2G7 MWrJckB3cXS{bzDjfZRwfG:6aXOgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CC3c3nu[{B1cGViaIXtZY4h\XCrZHXycY9q\CClYYLjbY5wdWFiY3XscEBtcW6nIFvCMVMuOSxiSVO1NF04KG6P MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR2M{e2N{c,OTJ2NEO3OlM9N2F-
human uterine sarcoma cell line MES-SA NX7BUHdoS3m2b4TvfIlkyqCjc4PhfS=> MkPxTY4hfmm2cn:gZ5l1d3SxeHnjJIFkfGm4aYT5JJdieyCndnHseYF1\WRidYPpcochfGinIHj1cYFvKHW2ZYLpcoUhe2G{Y3;tZUBk\WyuIHzpcoUhVUWVLWPBMEBKSzVyPUCuNFch|ryP NFLj[3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS0N|c3Oyd-MUK0OFM4PjN:L3G+
Jurkat T lymphocytes MVHDfZRwfG:6aXRCpIF{e2G7 MkfjR5l1d3SxeHnjbZR6KGGpYXnud5QhUnW{a3H0JHQhdHmvcHjvZ5l1\XNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFgzPiEQvF2= NV[5ZldqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zOlY3ODJpPkG2N|Y3PjB{PD;hQi=>
human HeLa3 cell line M3HDPWN6fG:2b4jpZ:Kh[XO|YYm= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiOyClZXzsJIxqdmViYomgUXRVKGG|c3H5MEBKSzVyPUKuPVYh|ryP M4LWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUSyNFM4Lz5zNkm0NlA{PzxxYU6=
NCI-H69 cell line NUHTV4wyWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1jQSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC|ZX7zbZRqfmViTlPJMWg3QSClZXzsJIxqdmViYomgRYxidWG{IFLseYUh[XO|YYmsJGlEPTB;MD6xJO69VQ>? NILBUG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K4OlM6Oyd-MUeyPFY{QTN:L3G+
L1210 MXHGeY5kfGmxbjDhd5NigQ>? NVT4T4VOUW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KGmwIH3veZNmKExzMkGwJINmdGy|LDDFSFUxKD1iMD6zJO69VS5? M4flNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzR{M{G4NUc,PDJ|MUixQE9iRg>?
L1210 M3raSGZ2dmO2aX;uJIF{e2G7 M4\MNGlvcGmkaYTpc44hd2ZiRF7BJJN6dnSqZYPpd{BqdiCvb4Xz[UBNOTJzMDDj[YxteyxiRVS1NEA:KDFizszNMi=> MmOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPDJ|MUixK|41OjNzOEG8M4E,
L1210 MX;GeY5kfGmxbjDhd5NigQ>? NHv6[5pKdmirYnn0bY9vKG:oIGLORUB{gW62aHXzbZMhcW5ibX;1d4UhVDF{MUCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdeZJq\GmwZTDpcoNwenCxcnH0bY9vNCCHREWwJF0hOC5|IN88UU4> NUHPUHlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNEmwOVM4Lz52OUC1N|c9N2F-
L1210 MnzHSpVv[3Srb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKESQQTDzfY51cGW|aYOgbY4hdW:3c3WgUFEzOTBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBcO0ifdHj5cYllcW6nIHnuZ49zeG:{YYTpc44tKEWGNUCgQUAxNjRizszNMi=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek81QTB3M{enQlQ6ODV|N{yvZV4>
L1210 NXTxeGZrTnWwY4Tpc44h[XO|YYm= M1y1emlvcGmkaYTpc44hd2ZiW{PIYZVzcWSrbnWgbY5kd3Kyb4LheIlwdiCrboTvJJBzd2yrZnXyZZRqdmdiTEGyNVAh[2WubIOsJGVFPTBiPTCwMlM{KM7:TT6= NGq2b3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi94N{G2OFAyLz54N{G2OFAyRC:jPh?=
L1210 MoT2SpVv[3Srb36gZZN{[Xl? NH;jUVRKdmirYnn0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDpcpRwKHC{b3zp[oVz[XSrbnegUFEzOTBiY3XscJMtKEWGNUCgQUAxNjZ4IN88UU4> NXfDVpJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNkexOlQxOSd-NkexOlQxOTxxYU6=
L1210 NVW3N2JmTnWwY4Tpc44h[XO|YYm= MVnEc5NmKHKncYXpdoVlKHSxIHnubIljcXRidHjlJHJPSSC|eX70bIV{cXNiaX6gcIV2c2WvaXGgUFEzOTBiY3XscJMtKEWGNUCgQUAxNjNizszNMi=> NFrVUoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MkWyPVc3Lz55MkWyPVc3RC:jPh?=
L1210 MX\GeY5kfGmxbjDhd5NigQ>? NGnnRpdFd3OnIILldZVqemWmIITvJIlvcGmkaYSgeIhmKESQQTDzfY51cGW|aYOgbY4hdGW3a3XtbYEhVDF{MUCgZ4VtdHNuIFXEOVAhRSBzIN88UU4> NIG3WHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MkWyPVc3Lz55MkWyPVc3RC:jPh?=
MCF7 Mk[3R5l1d3SxeHnjbZR6KGG|c3H5 MVO0PEBpenN? M1m5NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjJizszNMi=> M1T2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUmwOFQ4Lz5zN{G5NFQ1PzxxYU6=
MDA-MB-231 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NIDSbXM1QCCqcoO= M1jlS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNlUh|ryPLh?= M2HHelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUmwOFQ4Lz5zN{G5NFQ1PzxxYU6=
HeLa NVfIc|A1S3m2b4TvfIlkcXS7IHHzd4F6 MUm0PEBpenN? NF6zU4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN{IN88UU4> MoixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOUC0OFcoRjF5MUmwOFQ4RC:jPh?=
PC-3 MmO0R5l1d3SxeHnjbZR6KGG|c3H5 NF3DUpU1QCCqcoO= MnXuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGMuOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE41PCEQvF2u MnOxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOUC0OFcoRjF5MUmwOFQ4RC:jPh?=
Yoshida sarcoma tumor cells MknGSpVv[3Srb36gZZN{[Xl? Mo\qR49v[2WwdILheIlwdiCrbnjpZol1cW6pIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckBqdiC\b4PobYRiKHOjcnPvcYEhfHWvb4KgZ4VtdHNiaX6geol1em9iaX6gdoF1eyxiSVO1NEA:KDBwMEKg{txONg>? NIDYXJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{KyPVg3Lz5zM{KyPVg3RC:jPh?=
HL60 NHTH[lJCeG:ydH;zbZMh[XO|YYm= MUjJckB3cXS{bzDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnu[JVk\SCjcH;weI9{cXNiaX6gTGw3OCClZXzsd{whSUN3MDC9JFAvODRizszNMi=> NXzVNoxIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4O|c2QTNpPkGyPFc4PTl|PD;hQi=>
HL60R NI\uWYZCeG:ydH;zbZMh[XO|YYm= MX;JckB3cXS{bzDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnu[JVk\SCjcH;weI9{cXNiaX6gTGw3OFJiY3XscJMtKEGFNUCgQUAyOCEQvF2u NYfNR|RVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4O|c2QTNpPkGyPFc4PTl|PD;hQi=>
HL60 M{j4XGN6fG:2b4jpZ4l1gSCjc4PhfS=> NE\r[4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFQ5KGi{czDifUB1enmyYX6gZox2\SCneHPseZNqd25ibXX0bI9lNCCDQ{WwJF0hOC5zIN88UU4> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN|OUS1OUc,OTh|M{m0OVU9N2F-
HL60 MV3BdI9xfG:|aYOgZZN{[Xl? M3j4TGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gcZVtfGmmcoXnJJJme2m|dHHueEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IES4JIhzeyxiQVO1NEA:KDN6IN88UU4> MoLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|M{m0OVUoRjF6M{O5OFU2RC:jPh?=
HTB-81 NH3ncHBEgXSxdH;4bYNqfHliYYPzZZk> NYKzNZJwS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDoeY1idiCycn;zeIF1\SClYX7j[ZIhUFSELUixJINmdGy|IIXzbY5oKE2WUzDhd5NigSxiRVO1NEA:KDBwMEW4JO69VS5? M1fXV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg2Lz5zMUCyNFI5PTxxYU6=
B16 NEe3W4hEgXSxdH;4bYNqfHliYYPzZZk> NUXhPYhzS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDCNVYhdW:3c3WgcYVt[W6xbXGgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwJF0hOC5zNjFOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4OUc,OTFyMkCyPFU9N2F-
fibroblast (NHF) cells M1;2ZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEfp[YZEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIH7vdo1idCCqdX3hckBncWK{b3LsZZN1KCiQSF[pJINmdGy|IIXzbY5oKE2WUzDhd5NigSxiRVO1NEA:KDBwMkKg{txONg>? Mnr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFUoRjFzMEKwNlg2RC:jPh?=
L1210 NEPjZVhHfW6ldHnvckBie3OjeR?= NHj3SpA{KGi{cx?= MlPpTY5pcWKrdHnvckBw\iCGTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOyCqcoOg[o9tdG:5ZXSgZpkhYzOKXT30bJlucWSrbnWgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSC|Y3nueIltdGG2aX;uJJNx\WO2cn;t[ZRzcWNiYX7hcJl{cXNuIFXEOVAhRSByLkOg{txONg>? NHvuU2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[zOVkoRjF5NkO1PVww[T5?
L1210 M4HUN2Z2dmO2aX;uJIF{e2G7 NFXNN|U{KGi{cx?= NYe0dXU1UW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KGmwIH3veZNmKExzMkGwJINmdGy|IIDy[Ylv[3WkYYTl[EBnd3JiMzDodpMh\m:ubH;3[YQh[nliW{PIYU12emmmaX7lJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nlic3PpcpRqdGyjdHnvckB{eGWldILvcYV1emmlIHHuZYx6e2m|LDDFSFUxKD1iMD6zJO69VS5? Mon5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4M{W5K|4yPzZ|NUm8M4E,
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SK-N-MC NIm4bIpyUFSVIHHzd4F6 NIDubFZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> M3jZOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37 MnPSdWhVWyCjc4PhfS=> MU\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? M2fhOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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BT-12 MlrEdWhVWyCjc4PhfS=> MXnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvMUKgZ4VtdHN? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh18 NHfSVJpyUFSVIHHzd4F6 NXz0co9EeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO= M3fENlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50 MlHKdWhVWyCjc4PhfS=> M3:2bZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCRSGOtOVAh[2WubIO= NX3YTHpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
RD MWrxTHRUKGG|c3H5 MmXVdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{ M2TT[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R) MmjsdWhVWyCjc4PhfS=> MlXrdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy| MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
fibroblast cells MnmydWhVWyCjc4PhfS=> M4rQUJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiClb370do9tKEiqIIfpcIQhfHmyZTDmbYJzd2KuYYP0JINmdGy| NEHVWVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Rh41 M2PrNJFJXFNiYYPzZZk> M4L0S5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaESxJINmdGy| MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
P388 M2CxWmFvfGm2dX3vdkBie3OjeR?= MlPkNE4zPSC2bzCxNEBu\y:tZx?= MYnBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCSM{i4JINmdGy|IHHscI9oemGodHXkJIlvKG2xdYPlJIF{e2W|c3XkJIF{KHS3bX;yJIdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMkWgeI8hOTBibXevb4c> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjV3Nk[xK|4yOjV3Nk[xQE9iRg>?
Assay
Methods Test Index PMID
Western blot p-Chk1 / Chk1 / p-ATR / ATR 26727128
Immunofluorescence p-Chk1 26727128
Growth inhibition assay Cell viability 30745844

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(177.31 mM)
Water 100 mg/mL
(177.31 mM)
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 563.98
Formula

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04562792 Recruiting Drug: Daunorubicin Relapsed Pediatric ALL|Relapsed Pediatric AML|Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City May 8 2020 Phase 2
NCT03878927 Recruiting Drug: CPX-351|Drug: Gemtuzumab Ozogamicin Acute Myeloid Leukemia Weill Medical College of Cornell University|Jazz Pharmaceuticals|Pfizer August 23 2019 Phase 1
NCT03896269 Unknown status Drug: Liposome-encapsulated Daunorubicin-Cytarabine Blasts 10-19 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|High Risk Chronic Myelomonocytic Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory High Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 14 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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