Daunorubicin (RP 13057) HCl

Catalog No.S3035 Synonyms: Daunomycin HCl, Rubidomycin HCl

For research use only.

Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

Daunorubicin (RP 13057) HCl Chemical Structure

CAS No. 23541-50-6

Selleck's Daunorubicin (RP 13057) HCl has been cited by 53 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
Targets
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
In vitro

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA MB 361(mammary carcinoma cell line) M1P0fGN6fG:2b4jpZ:Kh[XO|YYm= M3;IdHRp\SClb33wc5Vv\CC5YYOgeIV{fGWmIH\vdkBqdnS{YXPlcIx2dGG{IHP5eI91d3irY3n0fUBi\2GrboP0JG1FSSCPQjCzOlEpdWGvbXHyfUBk[XKlaX7vcYEh[2WubDDsbY5mMSCneIDy[ZN{cW6pIFzhZ3ohMGKndHGt[4Ft[WO2b4Pp[IF{\SluIFnDOVA:OTdibl2= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN7NUS5NEc,OTB|OUW0PVA9N2F-
P388 leukemia cell line MXPDfZRwfG:6aXRCpIF{e2G7 M3nEbWNwdXCxdX7kJJdieyCndnHseYF1\WRiZn;yJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFB|OEigcIV2c2WvaXGgZ4VtdCCuaX7lMEBKSzVyPUOgcm0> NWTtc41sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0O|kzQTdpPkGwOFc6Ojl5PD;hQi=>
Dx5 w/PSC cell lines M3rXe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHUbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGR5PSC5L2DTR{Bk\WyuIHzpcoV{KHW|aX7nJG1VXCCjc4PhfUwhUUN3ME2xOEBvVQ>? MnHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB4OUi0OFkoRjFyNkm4OFQ6RC:jPh?=
MES-SA uterine tumor cell lines MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH[0THBVcGViY3;tdI92dmRid3HzJIV3[Wy3YYTl[EBnd3JidHjlJIdzd3e2aDDpcohq[mm2aX;uJI9nKE2HUz3TRUB2fGW{aX7lJJR2dW:{IHPlcIwhdGmwZYOgeZNqdmdiTWTUJIF{e2G7LDDJR|UxRTBwMEKxJO69VQ>? M3jHe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNkm4OFQ6Lz5zME[5PFQ1QTxxYU6=
Dx5 cell lines MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUDaO41CXGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCGeEWgZ4VtdCCuaX7ld{B2e2mwZzDNWHQh[XO|YYmsJIlkPTB;MjFOwG0> NVXqcokzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC2PVg1PDlpPkGwOlk5PDR7PD;hQi=>
human epidermoid carcinoma cell line KB-3-1 NFfUS5REgXSxdH;4bYPDqGG|c3H5 NH3N[FRKdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5iZYDp[IVzdW:rZDDjZZJkcW6xbXGgZ4VtdCCuaX7lJGtDNTNvMTygTWM2OD15IH7N NVzSPJpKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0OFM4PjNpPkGyOFQ{PzZ|PD;hQi=>
human uterine sarcoma cell line MES-SA MmjzR5l1d3SxeHnjxsBie3OjeR?= M{LHd2lvKH[rdILvJIN6fG:2b4jpZ{Bi[3Srdnn0fUB4[XNiZY\hcJVifGWmIIXzbY5oKHSqZTDoeY1idiC3dHXybY5mKHOjcnPvcYEh[2WubDDsbY5mKE2HUz3TRUwhUUN3ME2wMlA4KM7:TR?= NVi2bVgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0OFM4PjNpPkGyOFQ{PzZ|PD;hQi=>
Jurkat T lymphocytes NYXubY1VS3m2b4TvfIlkyqCjc4PhfS=> MkmzR5l1d3SxeHnjbZR6KGGpYXnud5QhUnW{a3H0JHQhdHmvcHjvZ5l1\XNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFgzPiEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN4Nk[wNkc,OTZ|Nk[2NFI9N2F-
human HeLa3 cell line MXXDfZRwfG:6aXRCpIF{e2G7 M{fEU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGF|IHPlcIwhdGmwZTDifUBOXFRiYYPzZZktKEmFNUC9Nk46PiEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl2MkCzO{c,OTZ7NEKwN|c9N2F-
NCI-H69 cell line NGjJVYFRem:uaX\ldoF1cW:wIHHzd4F6 NI\TN4xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdic3Xud4l1cX[nIF7DTU1JPjliY3XscEBtcW6nIHL5JGFt[W2jcjDCcJVmKGG|c3H5MEBKSzVyPUCuNUDPxE1? M1v4XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mki2N|k{Lz5zN{K4OlM6OzxxYU6=
L1210 NIDCcHBHfW6ldHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOgbY4hdW:3c3WgUFEzOTBiY3XscJMtKEWGNUCgQUAxNjNizszNMi=> NYHyfoo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNEKzNVgyLz52MkOxPFE9N2F-
L1210 M2nRNmZ2dmO2aX;uJIF{e2G7 NHjJZXlKdmirYnn0bY9vKG:oIFTORUB{gW62aHXzbZMhcW5ibX;1d4UhVDF{MUCgZ4VtdHNuIFXEOVAhRSBzIN88UU4> NHHydW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi92MkOxPFEoRjR{M{G4NVww[T5?
L1210 NWTQb4h7TnWwY4Tpc44h[XO|YYm= Ml\FTY5pcWKrdHnvckBw\iCUTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYXybYRqdmViaX7jc5Jxd3KjdHnvckwhTUR3MDC9JFAvOyEQvF2u M4D0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzR7MEWzO{c,PDlyNUO3QE9iRg>?
L1210 NUDpXYVoTnWwY4Tpc44h[XO|YYm= MonLTY5pcWKrdHnvckBw\iCGTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vNCCHREWwJF0hOC52IN88UU4> NFLkUG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi92OUC1N|coRjR7MEWzO|ww[T5?
L1210 MUXGeY5kfGmxbjDhd5NigQ>? MoHTTY5pcWKrdHnvckBw\iCdM1jdeZJq\GmwZTDpcoNwenCxcnH0bY9vKGmwdH:gdJJwdGmoZYLheIlv\yCOMUKxNEBk\WyuczygSWQ2OCB;IECuN|Mh|ryPLh?= NHHpZ289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi94N{G2OFAyLz54N{G2OFAyRC:jPh?=
L1210 MWjGeY5kfGmxbjDhd5NigQ>? M2XnVmlvcGmkaYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHnueI8heHKxbHnm[ZJifGmwZzDMNVIyOCClZXzsd{whTUR3MDC9JFAvPjZizszNMi=> MoeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPjdzNkSwNUc,PjdzNkSwNVww[T5?
L1210 Mn;RSpVv[3Srb36gZZN{[Xl? NFezRWpFd3OnIILldZVqemWmIITvJIlvcGmkaYSgeIhmKFKQQTDzfY51cGW|aYOgbY4hdGW3a3XtbYEhVDF{MUCgZ4VtdHNuIFXEOVAhRSByLkOg{txONg>? MnrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzJ3Mkm3Okc,PzJ3Mkm3Olww[T5?
L1210 M33zfmZ2dmO2aX;uJIF{e2G7 MlfVSI9{\SC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBFVkFic4nueIhme2m|IHnuJIxmfWunbXnhJGwyOjFyIHPlcIx{NCCHREWwJF0hOSEQvF2u M1rBT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd{NUK5O|YoRjd{NUK5O|Y9N2F-
MCF7 MULDfZRwfG:6aXPpeJkh[XO|YYm= MVi0PEBpenN? NUDCdpp6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5{MjFOwG0v M1\TcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUmwOFQ4Lz5zN{G5NFQ1PzxxYU6=
MDA-MB-231 NXfHdJh7S3m2b4TvfIlkcXS7IHHzd4F6 MYq0PEBpenN? MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkK1JO69VS5? Mo\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOUC0OFcoRjF5MUmwOFQ4RC:jPh?=
HeLa M{H3NWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFqxbmY1QCCqcoO= NWfndHdES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5|MjFOwG0v NFjMTIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G5NFQ1Pyd-MUexPVA1PDd:L3G+
PC-3 NGj5UFdEgXSxdH;4bYNqfHliYYPzZZk> MlnkOFghcHK| NULhXHFUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWENvMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC52NDFOwG0v NVL3ZXpORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPVA1PDdpPkG3NVkxPDR5PD;hQi=>
Yoshida sarcoma tumor cells MkfCSpVv[3Srb36gZZN{[Xl? MnTDR49v[2WwdILheIlwdiCrbnjpZol1cW6pIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckBqdiC\b4PobYRiKHOjcnPvcYEhfHWvb4KgZ4VtdHNiaX6geol1em9iaX6gdoF1eyxiSVO1NEA:KDBwMEKg{txONg>? NWLaSJBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUOyNlk5Pid-MUOyNlk5PjxxYU6=
HL60 M3\JT2Fxd3C2b4Ppd{Bie3OjeR?= NYTCUZJtUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmS3Y3WgZZBweHSxc3nzJIlvKEiONkCgZ4VtdHNuIFHDOVAhRSByLkC0JO69VS5? MlHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6N{e1PVMoRjF{OEe3OVk{RC:jPh?=
HL60R MWHBdI9xfG:|aYOgZZN{[Xl? NEHUO4dKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJIlv\HWlZTDhdI9xfG:|aYOgbY4hUEx4MGKgZ4VtdHNuIFHDOVAhRSBzMDFOwG0v NYDvU2R{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4O|c2QTNpPkGyPFc4PTl|PD;hQi=>
HL60 NUjLRYtnS3m2b4TvfIlkcXS7IHHzd4F6 MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTD0dplx[W5iYnz1[UBmgGOudYPpc44hdWW2aH;kMEBCSzVyIE2gNE4yKM7:TT6= NWD5bVJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizN|k1PTVpPkG4N|M6PDV3PD;hQi=>
HL60 NILwR3hCeG:ydH;zbZMh[XO|YYm= Ml;sTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDteYx1cWS{dXegdoV{cXO2YX70JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiNEigbJJ{NCCDQ{WwJF0hOzhizszNMi=> M1niTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{O5OFU2Lz5zOEOzPVQ2PTxxYU6=
HTB-81 NEDKSndEgXSxdH;4bYNqfHliYYPzZZk> M{TjO2N6fG:2b4jpZ4l1gSC2aHH0JINifXOnZDDhJFUxLSC{ZXT1Z5Rqd25iaX6gZYJ{d3KkYX7j[UBifCB2OUCgco0hcW5iaIXtZY4heHKxc4TheIUh[2GwY3XyJGhVSi16MTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUCgQUAxNjB3ODFOwG0v NGjOSHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5PSd-MUGwNlAzQDV:L3G+
B16 M1O1SWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGq0SYNEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIFKxOkBud3W|ZTDt[Yxidm:vYTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUCgQUAxNjF4IN88UU4> M4DGRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg2Lz5zMUCyNFI5PTxxYU6=
fibroblast (NHF) cells NUntboVTS3m2b4TvfIlkcXS7IHHzd4F6 Mkf4R5l1d3SxeHnjbZR6KHSqYYSgZ4F2e2WmIHGgOVAmKHKnZIXjeIlwdiCrbjDhZpNwemKjbnPlJIF1KDR7MDDucUBqdiCwb4LtZYwhcHWvYX6g[oljem:kbHHzeEApVkiIKTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUCgQUAxNjJ{IN88UU4> MonYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFUoRjFzMEKwNlg2RC:jPh?=
L1210 MnTXSpVv[3Srb36gZZN{[Xl? MlfvN{BpenN? MlLiTY5pcWKrdHnvckBw\iCGTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOyCqcoOg[o9tdG:5ZXSgZpkhYzOKXT30bJlucWSrbnWgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSC|Y3nueIltdGG2aX;uJJNx\WO2cn;t[ZRzcWNiYX7hcJl{cXNuIFXEOVAhRSByLkOg{txONg>? NFzFS3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[zOVkoRjF5NkO1PVww[T5?
L1210 M3L4WWZ2dmO2aX;uJIF{e2G7 M{KxXVMhcHK| NV7GbYxiUW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KGmwIH3veZNmKExzMkGwJINmdGy|IIDy[Ylv[3WkYYTl[EBnd3JiMzDodpMh\m:ubH;3[YQh[nliW{PIYU12emmmaX7lJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nlic3PpcpRqdGyjdHnvckB{eGWldILvcYV1emmlIHHuZYx6e2m|LDDFSFUxKD1iMD6zJO69VS5? NEPPOlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[zOVkoRjF5NkO1PVww[T5?
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breast carcinoma line cells NWPybXhQTnWwY4Tpc44h[XO|YYm= M33kNYNwdXCxdX7kJJdieyC2ZYP0[YQhcW5idnn0do8h\m:{IHnubIljcXSrb36gZYN1cX[rdImgZYdicW6|dDDkc5hwenWkaXPpckBz\XOrc4ThcpQh[2:3boTldpBienRib3[gbJVu[W5iYoLlZZN1KGOjcnPpco9u[SCuaX7lJINmdGy|LDDJR|UxKD1iMjFOwG0v M2LENVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl{NUizOVEoRjl{NUizOVE9N2F-
MCF-7 NXXPOVRzTnWwY4Tpc44h[XO|YYm= Mme1R49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiaYTzJJRwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuczjNR2YuPyluIFnDOVAhRSByLkC2JO69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PTR6OEKwK|46PTR6OEKwQE9iRg>?
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Rh18 Ml3KdWhVWyCjc4PhfS=> MXrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>? NETOe4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
OHS-50 NYCz[Xo3eUiWUzDhd5NigQ>? NWPJV2w2eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=> M3Xhc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD MV\xTHRUKGG|c3H5 M4DiXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCURDDj[Yxtew>? NF;odYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
MG 63 (6-TG R) MYTxTHRUKGG|c3H5 NGrxTpdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTVegOlMhMDZvVFegVkkh[2WubIO= M{jZTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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P388 MlnyRY51cXS3bX;yJIF{e2G7 M2n6dlAvOjVidH:gNVAhdWdxa3e= NGTTTHBCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBud3W|ZTDQN|g5KGOnbHzzJIFtdG:pcnHmeIVlKGmwIH3veZNmKGG|c3Xzd4VlKGG|IIT1cY9zKGe{b4f0bEBqdmirYnn0bY9vKGG2IECuNlUhfG9iMUCgcYcwc2d? Mm\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ3NU[2NUc,OTJ3NU[2NVww[T5?
Assay
Methods Test Index PMID
Western blot p-Chk1 / Chk1 / p-ATR / ATR 26727128
Immunofluorescence p-Chk1 26727128
Growth inhibition assay Cell viability 30745844

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 563.98
Formula

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04562792 Recruiting Drug: Daunorubicin Relapsed Pediatric ALL|Relapsed Pediatric AML|Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City May 8 2020 Phase 2
NCT03878927 Recruiting Drug: CPX-351|Drug: Gemtuzumab Ozogamicin Acute Myeloid Leukemia Weill Medical College of Cornell University|Jazz Pharmaceuticals|Pfizer August 23 2019 Phase 1
NCT03896269 Recruiting Drug: Liposome-encapsulated Daunorubicin-Cytarabine Blasts 10-19 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|High Risk Chronic Myelomonocytic Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory High Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 14 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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