Mitoxantrone 2HCl

Catalog No.S2485 Synonyms: NSC-301739

Mitoxantrone 2HCl Chemical Structure

Molecular Weight(MW): 517.4

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
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Cited by 14 Publications

5 Customer Reviews

  • Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.

    Cell, 2018, 174(5):1200-1215. Mitoxantrone 2HCl purchased from Selleck.

  • Blockade of USP11 by pharmacological inhibitor Mitoxantrone destabilizes XIAP protein in MDA-MB-231 cells. MDA-MB-231 cells were treated with Mitoxantrone at indicated concentration for 24 h.

    EBioMedicine, 2017, 15:48-61. Mitoxantrone 2HCl purchased from Selleck.

  • C18SH: C18NH2 mixed monolayer. Panel A: Cyclic voltammograms of MTX at various scan rates (1) 9 mV/s, (2) 36 mV/s, (3) 64 mV/s, (4) 100 mV/s. Panel B: Bode plots (circles) with fit (solid line) and corresponding electrical equivalent circuit (inset); 1×10-5 M MTX(Mitoxantrone) in aqueous 0.1 M LiClO4, pH = 5.6, E = 0.4 V.

    Electrochimica Acta, 2015, 165:430-442.. Mitoxantrone 2HCl purchased from Selleck.

  • Rate of apoptosis induced by 24-h treatment of 1 µM mitoxantrone normalized to DMSO-treated samples in sporadic gastric cancer SNU-16 and hereditary c.1380delA SB.mhdgc-1 cells. Flow cytometry profiles of FITC-labeled anti-BrdU staining of 3′-hydroxyl (OH) termini of double- and single-stranded DNA, relative BrdU fractions normalized to DMSO-treated control shown on the right.

    J Transl Med, 2017, 15(1):92. Mitoxantrone 2HCl purchased from Selleck.

  • The viability of LKB1 knockdown cells was decreased more significantly compared with control cells after treatment with mitoxantrone. *P<0.01, vs LKB1-KD; **P<0.001, vs LKB1-KD.

    Mol Cell Biochem, 2017, 434(1-2):25-32. Mitoxantrone 2HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
Targets
Topoisomerase II [1]
In vitro

Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. [1] Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. [2] Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 cell NELVcWREgXSxdH;4bYNqfHliYYPzZZk> NY\EUWVjPDhiaB?= NYHzd5ZvS3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCOMUKxNEBk\WyuIHfyc5d1cCCkeTC1NEUh[W[2ZYKgZ4VtdCCmcoXnJINwdnSjY4Sg[o9zKDR6IHjyd{whUUN3ME20[U0xPSEQvF2= M33mOVk{PzF{NEC=
HL60 cells NWHXfFM3S3m2b4TvfIlkcXS7IHHzd4F6 NIPaRpo1QCCq NXPwcJZ[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVAvOzNizszN NWjWdHJ6OTd7NkKwNlg>
MDA435/LCC6 cells MUXQdo9tcW[ncnH0bY9vKGG|c3H5 NXPNU4M2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBOTEF2M{WvUGNEPiClZXzsd{BjgSCHTFnTRUwhUUN3ME2wMlM2KG6P M320NVE4OTV2NUC1
A2780-cell M4\DSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUKxTI1HS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JGEzPzhyLXPlcIwh\3Kxd4ToJIJ6KDVyJTygTWM2OD1yLkW1JI5O MV25O|A{PDdz
G-361 cell NGTzSItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TkfmN6fG:2b4jpZ{Bxd3SnbnP5JJJmeXWrcnXkJJRwKGmwaHnibZQhTy1|NkGgZ4VtdCCpcn;3eIgh[nliNUClMEBKSzVyPUCuOlUhdk1? NYfVVlc4QTN5MUK0NC=>
human HL60 cells M1PTU3Bzd2yrZnXyZZRqd25iYYPzZZk> Ml35O|IhcA>? MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjVibl2= MX2yNlk1PDF{MR?=
human K562 cells NX\q[mFpS3m2b4TvfIlkcXS7IHHzd4F6 MkfKOUBl[Xm| NWPCSVFCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA2KGSjeYOgZpkhYFSWIHHzd4F6NCCLQ{WwQVIvPiCwTR?= NFLqe2EyQDB5NkG0NC=>
CH1 cell M4jUcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXTjXm8xS3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCFSEGgZ4VtdCCpcn;3eIgh[nliNUClMEBKSzVyPUKuOlUhdk1? NFvGRVE6OzdzMkSw
MES-SA cells MVPQdo9tcW[ncnH0bY9vKGG|c3H5 MXS3NkBp MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3FV{1USSClZXzsd{BjgSCPVGSgZZN{[XliYX\0[ZIhPzJiaILzMEBKSzVyPUOgcm0> MoDZNVY5OjR5NUG=
A549 cells NYTDSlJuTnWwY4Tpc44h[XO|YYm= NGDHPI1C[3Srdnn0fUBi\2GrboP0JGE2PDliY3HuZ4VzKGOnbHygcIlv\SxiSVO1NF0{NjFibl2= M3;MUlg6PjB3NUi=
LoVo cells NVnue2JmS3m2b4TvfIlkcXS7IHHzd4F6 M2i4NlE1PCCq MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOjbnPldkBk\WyuIHzpcoUhf2G|IHTleIVzdWmwZXSgZYZ1\XJiMUS0JIhzNCCLQ{WwQVMvOyCwTR?= MWexOVQ2PjJ4OB?=
P388 cells MYjQdo9tcW[ncnH0bY9vKGG|c3H5 MofNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDQN|g5KGOnbHzzJIJ6KEWOSWPBMEBKSzVyPUSuN{BvVQ>? NXHWZm5kOTdzNUS1NFU>
human Daudi cells M3r0SXBzd2yrZnXyZZRqd25iYYPzZZk> M3XDbVczKGh? MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESjdXTpJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PSCwTR?= Mn\UNlU6QTh3MES=
SKOV-3 cell NWfOc|RNS3m2b4TvfIlkcXS7IHHzd4F6 M3LSRmN6fG:2b4jpZ{Bxd3SnbnP5JJJmeXWrcnXkJJRwKGmwaHnibZQhW0uRVj2zJINmdGxiZ4Lve5RpKDVyJTygTWM2OD13LkOgcm0> MnHzPVM4OTJ2MB?=
OVCAR-3 cell NHX3WWJHfW6ldHnvckBie3OjeR?= M1TaVmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIH;2ZZJq[W5iT2\DRXIuOyClZXzsJIxqdmW|LDDJR|UxRTVwODDuUS=> M2HFUVg6PjB3NUi=
human MES-SA cells MW\Qdo9tcW[ncnH0bY9vKGG|c3H5 M3rn[VczKGh? MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2HUz3TRUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTZibl2= MViyOVk6QDVyNB?=
PC3 cancer cell NFnibIlEgXSxdH;4bYNqfHliYYPzZZk> MWWxOFQhcA>? M1PGXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClYX7j[ZIh[2WubDDsbY5mKHejczDk[ZRmem2rbnXkJIFnfGW{IEG0OEBpeixiSVO1NF04KG6P M2PpWlE2PDV4Mk[4
MXF7 breast cell NGPEPFZHfW6ldHnvckBie3OjeR?= MnfoRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5ibXHtcYFzgSClYYLjbY5wdWFic3Xud4l1cX[nIF3YSlch[nKnYYP0JINmdGxibHnu[UwhUUN3ME24Mlchdk1? M3G4[Fg6PjB3NUi=
HT-29 cell NWLJO3JqS3m2b4TvfIlkcXS7IHHzd4F6 NY\ldZJOOTR2IHi= NW\i[5NFS3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCKVD2yPUBk\WyuIHfyc5d1cCCkeTC1NEUh[W[2ZYKgZ4VtdCCmcoXnJINwdnSjY4Sg[o9zKDF2NDDodpMtKEmFNU2wMlAyKM7:TR?= NYjQXY05QTN5MUK0NC=>
HEK293 cells MYPDfZRwfG:6aXPpeJkh[XO|YYm= MXi3NkBp NGHnb2lEgXSxdH;4bYNqfHliYXfhbY5{fCCKRVuyPVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkCxJO69VQ>? MmXUNlQ3OTF6OUO=
MKN45 cells NV;sTnZiS3m2b4TvfIlkcXS7IHHzd4F6 NHfJNo4yPDRiaB?= MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClYX7j[ZIh[2WubDDsbY5mKHejczDk[ZRmem2rbnXkJIFnfGW{IEG0OEBpeixiSVO1NF0xNjBzMjFOwG0> MYmxOVQ2PjJ4OB?=
MES-SA cells MVvDfZRwfG:6aXPpeJkh[XO|YYm= MkGwO|IhcA>? NXLrZZFTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUWVLWPBJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMUKg{txO NX\TO3R5OjF2NESyNFU>
FM3 cells MlHPVJJwdGmoZYLheIlwdiCjc4PhfS=> MX:3NkBp MlGzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCITUOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjBzMzFOwG0> M{jKeVI2QTl6NUC0
MCF-7 cells M1nB[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVPJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5idIXtc5Ih[2WubDDsbY5mKE2FRj23JIJz\WG|dDDh[IVvd2OjcnPpco9u[SxiSVO1NF0xNjB{IN88US=> M{DkN|c5PTN|NEW=
human small-cell lung cancer MmTkR5l1d3SxeHnjbZR6KGG|c3H5 M1PXN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJNu[WyuLXPlcIwhdHWwZzDjZY5k\XJiKGPDUGMqNCCLQ{WwQVAvODJizszN MlnCPFI2QDh|NR?=
human HCT116 cells NVzvZ|lXS3m2b4TvfIlkcXS7IHHzd4F6 NFHyfIg4OiCq MoXRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjJizszN MV[yNVQ1PDJyNR?=
human HCT116 cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 MVO3NkBp M4\HUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wNlUh|ryP MUmyOVk6QDVyNB?=
NCI-H460 cells MlXuR5l1d3SxeHnjbZR6KGG|c3H5 MmrIOFghcA>? NUmyeGRSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IILld4F7fXKrbjDkfYUh[XO|YYmsJGVEPTB;MD6wN{DPxE1? NHTNdYwzOzl6OEO1NS=>
CCRF-CEM cells MV7DfZRwfG:6aXPpeJkh[XO|YYm= NXXEU|R5PDhiaB?= Moe1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2NTTi2FRV2gZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KGOnbHz0bZRmei2kbIXlJIF{e2G7LDDJR|UxRTBwMEO2JO69VQ>? NHH5d4gzOjV6Mkm5NS=>
HeLa cells MnPCVJJwdGmoZYLheIlwdiCjc4PhfS=> NGrxSVc4OiCq NFTJVWVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkC0OEDPxE1? NF;MPVEzPTl7OEWwOC=>
NCI60 cells NYn1b5ZUTnWwY4Tpc44h[XO|YYm= NHSzUWU1QCCq M3PXSGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTVYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTB;NEeuPFYhdk1? MknuNVg4OTV5OE[=
UACC375 cell MkezSpVv[3Srb36gZZN{[Xl? MX\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCvZXzhco9u[SCXQVPDN|c2KGOnbHygcIlv\SxiSVO1NF0xNjB2ODFOwG0> MUS4PVYxPTV6
HT1080 cell NUHIWWpoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV75[oxHUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJJR2dW:{IHPlcIwhdGmwZTDIWFExQDBuIFnDOVA:OC5yNk[g{txO MWG3PFU{OzR3
MES-SA/Dx5 cells NWT2VZNpWHKxbHnm[ZJifGmxbjDhd5NigQ>? NVu0fIdMPzJiaB?= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2HUz3TRU9FgDViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA4OyEQvF2= NFfafoQzPTl7OEWwOC=>
SF268 cells MlGwVJJwdGmoZYLheIlwdiCjc4PhfS=> NX7oWJloPDhiaB?= M4G4WWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1[yOlgh[2WubIOgZYZ1\XJiNEigbJJ{NCCHQ{WwQVAvOzJizszN NEjGVnczOzN7NU[1Oi=>
KB/HeLa cells NHO1cVFRem:uaX\ldoF1cW:wIHHzd4F6 M{TLfVQ5KGh? M3;OPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1KvTIVN[SClZXzsd{Bi\nSncjC0PEBpenNuIFXDOVA:OC5|NjFOwG0> NXzmZ5NSOjN|OUW2OVY>
K562 cells MoHTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mo\5O|IhcA>? NIfEVGNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNibXX0bI9lNCCLQ{WwQVAvPDJizszN MXexPFI2QDR2Mh?=
MDA-MB-231 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 M2nnbVczKGh? NIDvUoVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYomgW3NVNTFibXX0bI9lKGGodHXyJFczKGi{czygTWM2OD1yLkm2JO69VQ>? NF7VS2cyPzN|NUG4PS=>
SF268 cells Mmf3R5l1d3SxeHnjbZR6KGG|c3H5 MV[0PEBp M4HGUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjZ6IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NE46PyEQvF2= MVOxO|k3OjB{OB?=
HCT116 cells M4HKXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NV\OTGI6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME2zMlk3KM7:TR?= NIXybYwzODl3MUW4Ni=>
U937 cells MX3DfZRwfG:6aXPpeJkh[XO|YYm= MoPOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi5{IN88US=> NWn5cWdmOTl4MUW5NFA>
HepG2 cells Mnn5VJJwdGmoZYLheIlwdiCjc4PhfS=> MlXiOFghcA>? M{Lq[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMT6wOUDPxE1? NEn5dJczPDd7NEe0Oy=>

... Click to View More Cell Line Experimental Data

In vivo Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. [4] Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand. [5]

Protocol

Solubility (25°C)

In vitro DMSO 89 mg/mL (172.01 mM)
Water 89 mg/mL (172.01 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 517.4
Formula

C22H29ClN4O6.2HCl

CAS No. 70476-82-3
Storage powder
in solvent
Synonyms NSC-301739

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02131688 Unknown status Drug: Mitoxantrone Hydrochloride Liposome Malignant Lymphoma CSPC ZhongQi Pharmaceutical Technology Co. Ltd. May 2013 Phase 1
NCT01701375 Terminated Drug: PD 0332991 Relapsed Acute Leukemia|Refractory Acute Leukemia|High-Risk Myelodysplasia Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|The Leukemia and Lymphoma Society|Pfizer September 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID