Mitoxantrone 2HCl

For research use only.

Catalog No.S2485 Synonyms: NSC-301739

20 publications

Mitoxantrone 2HCl Chemical Structure

CAS No. 70476-82-3

Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 120 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Mitoxantrone 2HCl has been cited by 20 publications

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.
Targets
Topoisomerase II [1]
In vitro

Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. [1] Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. [2] Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 cell NUHUbGRiS3m2b4TvfIlkcXS7IHHzd4F6 MUm0PEBp NUnER45ES3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCOMUKxNEBk\WyuIHfyc5d1cCCkeTC1NEUh[W[2ZYKgZ4VtdCCmcoXnJINwdnSjY4Sg[o9zKDR6IHjyd{whUUN3ME20[U0xPSEQvF2= MVe5N|cyOjRy
HL60 cells NVjZcW1JS3m2b4TvfIlkcXS7IHHzd4F6 NWDNd3Z[PDhiaB?= NWjxXHl6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVAvOzNizszN MofLNVc6PjJyMki=
MDA435/LCC6 cells MoPkVJJwdGmoZYLheIlwdiCjc4PhfS=> MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3ERVQ{PS:OQ1O2JINmdGy|IHL5JGVNUVODLDDJR|UxRTBwM{Wgcm0> NGnjfnEyPzF3NEWwOS=>
A2780-cell MlTWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrJTW5Ed26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgRVI4QDBvY3XscEBoem:5dHigZpkhPTBnLDDJR|UxRTBwNUWgcm0> NGPCNWg6PzB|NEex
G-361 cell NXrVWlNlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1yzdGN6fG:2b4jpZ{Bxd3SnbnP5JJJmeXWrcnXkJJRwKGmwaHnibZQhTy1|NkGgZ4VtdCCpcn;3eIgh[nliNUClMEBKSzVyPUCuOlUhdk1? M1nEelk{PzF{NEC=
human HL60 cells NIjZ[Y1Rem:uaX\ldoF1cW:wIHHzd4F6 NEXSVmI4OiCq Mn\0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:Oi53IH7N Mn7kNlI6PDRzMkG=
human K562 cells NFTCSo5EgXSxdH;4bYNqfHliYYPzZZk> MVm1JIRigXN? MlrSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC1JIRigXNiYomgXHRVKGG|c3H5MEBKSzVyPUKuOkBvVQ>? NYi1fYp1OThyN{[xOFA>
CH1 cell NIO3WFJEgXSxdH;4bYNqfHliYYPzZZk> NYTUfpRxS3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCFSEGgZ4VtdCCpcn;3eIgh[nliNUClMEBKSzVyPUKuOlUhdk1? NE\MWlQ6OzdzMkSw
MES-SA cells NXO5U5hUWHKxbHnm[ZJifGmxbjDhd5NigQ>? NFTNe404OiCq MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3FV{1USSClZXzsd{BjgSCPVGSgZZN{[XliYX\0[ZIhPzJiaILzMEBKSzVyPUOgcm0> M{nPTVE3QDJ2N{Wx
A549 cells MlvPSpVv[3Srb36gZZN{[Xl? NXuxe4FjSWO2aY\peJkh[WejaX7zeEBCPTR7IHPhcoNmeiClZXzsJIxqdmVuIFnDOVA:Oy5zIH7N NEXTdoQ5QTZyNUW4
LoVo cells NHO3PIdEgXSxdH;4bYNqfHliYYPzZZk> MYKxOFQhcA>? NIC0Z4tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNd1[xIHPhcoNmeiClZXzsJIxqdmVid3HzJIRmfGW{bXnu[YQh[W[2ZYKgNVQ1KGi{LDDJR|UxRTNwMzDuUS=> M1zZNlE2PDV4Mk[4
P388 cells MnLMVJJwdGmoZYLheIlwdiCjc4PhfS=> MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGCzPFgh[2WubIOgZpkhTUyLU1GsJGlEPTB;ND6zJI5O MYqxO|E2PDVyNR?=
human Daudi cells NIPnc21Rem:uaX\ldoF1cW:wIHHzd4F6 NYiwWVV7PzJiaB?= NHnqOFRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTheYRqKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NTDuUS=> MVmyOVk6QDVyNB?=
SKOV-3 cell MmLGR5l1d3SxeHnjbZR6KGG|c3H5 NGDmV2FEgXSxdH;4bYMheG:2ZX7jfUBz\XG3aYLl[EB1dyCrbnjpZol1KFONT2[tN{Bk\WyuIHfyc5d1cCB3MDWsJGlEPTB;NT6zJI5O NEfuTVI6OzdzMkSw
OVCAR-3 cell NIS2bnNHfW6ldHnvckBie3OjeR?= MXLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCxdnHybYFvKE:YQ1HSMVMh[2WubDDsbY5meyxiSVO1NF02Njhibl2= MoDSPFk3ODV3OB?=
human MES-SA cells NE\tbFRRem:uaX\ldoF1cW:wIHHzd4F6 Mkf5O|IhcA>? M4CwfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVXTMXNCKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NjDuUS=> NIL1[lAzPTl7OEWwOC=>
PC3 cancer cell MYLDfZRwfG:6aXPpeJkh[XO|YYm= NXHROJJuOTR2IHi= MnfPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOjbnPldkBk\WyuIHzpcoUhf2G|IHTleIVzdWmwZXSgZYZ1\XJiMUS0JIhzNCCLQ{WwQVchdk1? MUixOVQ2PjJ4OB?=
MXF7 breast cell MYDGeY5kfGmxbjDhd5NigQ>? MUjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCvYX3tZZJ6KGOjcnPpco9u[SC|ZX7zbZRqfmViTWjGO{BjemWjc4SgZ4VtdCCuaX7lMEBKSzVyPUiuO{BvVQ>? NGXTe3E5QTZyNUW4
HT-29 cell M1PFfWN6fG:2b4jpZ4l1gSCjc4PhfS=> NInpWZIyPDRiaB?= NHf3flhEgXSxdH;4bYMheG:2ZX7jfUBz\XG3aYLl[EB1dyCrbnjpZol1KEiWLUK5JINmdGxiZ4Lve5RpKGK7IEWwKUBi\nSncjDj[YxtKGS{dXegZ49vfGGldDDmc5IhOTR2IHjyd{whUUN3PUCuNFEh|ryP MWq5N|cyOjRy
HEK293 cells MUnDfZRwfG:6aXPpeJkh[XO|YYm= MkHaO|IhcA>? NFSyOo1EgXSxdH;4bYNqfHliYXfhbY5{fCCKRVuyPVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkCxJO69VQ>? NYHsZ|JmOjR4MUG4PVM>
MKN45 cells NFviRVlEgXSxdH;4bYNqfHliYYPzZZk> NEXnZVQyPDRiaB?= M13r[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1MVjR3IHPhcoNmeiClZXzsJIxqdmVid3HzJIRmfGW{bXnu[YQh[W[2ZYKgNVQ1KGi{LDDJR|UxRTBwMEGyJO69VQ>? NHrnR2IyPTR3NkK2PC=>
MES-SA cells MV7DfZRwfG:6aXPpeJkh[XO|YYm= MknOO|IhcA>? M2fGcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1GWy2VQTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF{IN88US=> MnP1NlE1PDR{MEW=
FM3 cells NF;5VmhRem:uaX\ldoF1cW:wIHHzd4F6 NX7tUlY3PzJiaB?= MoHYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCITUOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjBzMzFOwG0> NFjKU2ozPTl7OEWwOC=>
MCF-7 cells NWXPNFhuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHycXNNUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJJR2dW:{IHPlcIwhdGmwZTDNR2YuPyCkcnXhd5Qh[WSnbn;jZZJkcW6xbXGsJGlEPTB;MD6wNkDPxE1? M2HTRVc5PTN|NEW=
human small-cell lung cancer M3j4SWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmqyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gd41idGxvY3XscEBtfW6pIHPhcoNmeiBqU1PMR{ktKEmFNUC9NE4xOiEQvF2= MXW4NlU5QDN3
human HCT116 cells MnW5R5l1d3SxeHnjbZR6KGG|c3H5 MWq3NkBp M3S2SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODJ{IN88US=> MnXHNlE1PDR{MEW=
human HCT116 cells NXOyVpVqWHKxbHnm[ZJifGmxbjDhd5NigQ>? MlXaO|IhcA>? M{\veWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wNlUh|ryP MoLHNlU6QTh3MES=
NCI-H460 cells M1K4V2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnvnOFghcA>? NE\CUnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB2ODDodpMh[nlicnXzZZp2emmwIHT5[UBie3OjeTygSWM2OD1yLkCzJO69VQ>? MnPWNlM6QDh|NUG=
CCRF-CEM cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= NXvFe|RDPDhiaB?= M4O4TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNEWkZvQ1XNJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSClZXzseIl1\XJvYnz1[UBie3OjeTygTWM2OD1yLkCzOkDPxE1? MkfUNlI2QDJ7OUG=
HeLa cells NFrufZZRem:uaX\ldoF1cW:wIHHzd4F6 NEOxc444OiCq Ml7yRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yNESg{txO M{n2WVI2QTl6NUC0
NCI60 cells MUPGeY5kfGmxbjDhd5NigQ>? MUO0PEBp M17CbGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTVYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTB;NEeuPFYhdk1? Mm\RNVg4OTV5OE[=
UACC375 cell M2fHNGZ2dmO2aX;uJIF{e2G7 NGfxNFJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDt[Yxidm:vYTDVRWNEOzd3IHPlcIwhdGmwZTygTWM2OD1yLkC0PEDPxE1? MVO4PVYxPTV6
HT1080 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXL3WopOUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJJR2dW:{IHPlcIwhdGmwZTDIWFExQDBuIFnDOVA:OC5yNk[g{txO MYS3PFU{OzR3
MES-SA/Dx5 cells MUHQdo9tcW[ncnH0bY9vKGG|c3H5 NHS0TmI4OiCq MoixRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRWOtV2EwTHh3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xPzNizszN MkHNNlU6QTh3MES=
SF268 cells Mn\VVJJwdGmoZYLheIlwdiCjc4PhfS=> MlraOFghcA>? M33HOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1[yOlgh[2WubIOgZYZ1\XJiNEigbJJ{NCCHQ{WwQVAvOzJizszN M3XMNVI{Ozl3NkW2
KB/HeLa cells MWjQdo9tcW[ncnH0bY9vKGG|c3H5 MYC0PEBp NYnwO5FLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLRk9J\UyjIHPlcIx{KGGodHXyJFQ5KGi{czygSWM2OD1yLkO2JO69VQ>? NYC0eGUzOjN|OUW2OVY>
K562 cells M2HrN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYK3NkBp MnroS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKG2ndHjv[EwhUUN3ME2wMlQzKM7:TR?= NEX0d40yQDJ3OES0Ni=>
MDA-MB-231 cells MYrQdo9tcW[ncnH0bY9vKGG|c3H5 NHvNXo44OiCq NXXr[mROSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JHdUXC1zIH3leIhw\CCjZoTldkA4OiCqcoOsJGlEPTB;MD65OkDPxE1? M4PG[VE4OzN3MUi5
SF268 cells M3z5bmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFTSTmI1QCCq MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTSlI3QCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuPVch|ryP M{DwZlE4QTZ{MEK4
HCT116 cells NG\HO3pEgXSxdH;4bYNqfHliYYPzZZk> MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTNwOU[g{txO Mkj3NlA6PTF3OEK=
U937 cells MnyzR5l1d3SxeHnjbZR6KGG|c3H5 M4fmd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU6OzdiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTZwMjFOwG0> M{C1N|E6PjF3OUCw
HepG2 cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 NY\OfZZ{PDhiaB?= M2G5d2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMT6wOUDPxE1? MVKyOFc6PDd2Nx?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ROS1 / ROS1 / p-STAT3 / STAT3 / p-AKT / AKT / p-ERK / ERK; 

PubMed: 30108778     


Mechanism of action of mitoxantrone in HCC78 cells. Immunoblot analysis of p-ROS1, ROS1, p-STAT3, STAT3, p-AKT, AKT, p-ERK, ERK and GAPDH in HCC78 cells, cells were harvested after treatment with mitoxantrone for 48 h.

30108778
Growth inhibition assay
Cell number; 

PubMed: 24349321     


LNCaP 104-S, 104- R1, 104-R2, PC-3, and DU-145 cells were treated with increasing concentrations of mitoxantrone for 72 hrs. Relative cell number of LNCaP cells was determined by Hoechst dye 33258-based 96-well proliferation assay. Cell numbers were normalized to control (dimethylsulfoxide) of each cell line. Triple asterisks (***) represent statistically significant difference p < 0.001between the treated group and the control group.

24349321
In vivo

Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. [4] Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand. [5]

Protocol

Solubility (25°C)

In vitro DMSO 89 mg/mL (172.01 mM)
Water 89 mg/mL (172.01 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 517.4
Formula

C22H29ClN4O6.2HCl

CAS No. 70476-82-3
Storage powder
in solvent
Synonyms NSC-301739
Smiles C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04330820 Recruiting Drug: Venetoclax Oral Tablet Relapsed Adult AML Technische Universität Dresden|AbbVie April 6 2020 Phase 1|Phase 2
NCT02131688 Unknown status Drug: Mitoxantrone Hydrochloride Liposome Malignant Lymphoma CSPC ZhongQi Pharmaceutical Technology Co. Ltd. May 2013 Phase 1
NCT01701375 Terminated Drug: PD 0332991 Relapsed Acute Leukemia|Refractory Acute Leukemia|High-Risk Myelodysplasia Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|The Leukemia and Lymphoma Society|Pfizer September 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Topoisomerase Signaling Pathway Map

Related Topoisomerase Products

Tags: buy Mitoxantrone 2HCl | Mitoxantrone 2HCl supplier | purchase Mitoxantrone 2HCl | Mitoxantrone 2HCl cost | Mitoxantrone 2HCl manufacturer | order Mitoxantrone 2HCl | Mitoxantrone 2HCl distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID