Mitoxantrone 2HCl

Catalog No.S2485 Synonyms: NSC-301739

Mitoxantrone 2HCl Chemical Structure

Molecular Weight(MW): 517.4

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
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Cited by 17 Publications

5 Customer Reviews

  • Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.

    Cell, 2018, 174(5):1200-1215. Mitoxantrone 2HCl purchased from Selleck.

  • Blockade of USP11 by pharmacological inhibitor Mitoxantrone destabilizes XIAP protein in MDA-MB-231 cells. MDA-MB-231 cells were treated with Mitoxantrone at indicated concentration for 24 h.

    EBioMedicine, 2017, 15:48-61. Mitoxantrone 2HCl purchased from Selleck.

  • C18SH: C18NH2 mixed monolayer. Panel A: Cyclic voltammograms of MTX at various scan rates (1) 9 mV/s, (2) 36 mV/s, (3) 64 mV/s, (4) 100 mV/s. Panel B: Bode plots (circles) with fit (solid line) and corresponding electrical equivalent circuit (inset); 1×10-5 M MTX(Mitoxantrone) in aqueous 0.1 M LiClO4, pH = 5.6, E = 0.4 V.

    Electrochimica Acta, 2015, 165:430-442.. Mitoxantrone 2HCl purchased from Selleck.

  • Rate of apoptosis induced by 24-h treatment of 1 µM mitoxantrone normalized to DMSO-treated samples in sporadic gastric cancer SNU-16 and hereditary c.1380delA SB.mhdgc-1 cells. Flow cytometry profiles of FITC-labeled anti-BrdU staining of 3′-hydroxyl (OH) termini of double- and single-stranded DNA, relative BrdU fractions normalized to DMSO-treated control shown on the right.

    J Transl Med, 2017, 15(1):92. Mitoxantrone 2HCl purchased from Selleck.

  • The viability of LKB1 knockdown cells was decreased more significantly compared with control cells after treatment with mitoxantrone. *P<0.01, vs LKB1-KD; **P<0.001, vs LKB1-KD.

    Mol Cell Biochem, 2017, 434(1-2):25-32. Mitoxantrone 2HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
Targets
Topoisomerase II [1]
In vitro

Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. [1] Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. [2] Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 cell Mk[1R5l1d3SxeHnjbZR6KGG|c3H5 M4e1PFQ5KGh? NEXseFdEgXSxdH;4bYMheG:2ZX7jfUBz\XG3aYLl[EB1dyCrbnjpZol1KExzMkGwJINmdGxiZ4Lve5RpKGK7IEWwKUBi\nSncjDj[YxtKGS{dXegZ49vfGGldDDmc5IhPDhiaILzMEBKSzVyPUTlMVA2KM7:TR?= Mo\TPVM4OTJ2MB?=
HL60 cells MV;DfZRwfG:6aXPpeJkh[XO|YYm= MnnVOFghcA>? M17R[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhT0l3ME2wMlM{KM7:TR?= MXyxO|k3OjB{OB?=
MDA435/LCC6 cells MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3ERVQ{PS:OQ1O2JINmdGy|IHL5JGVNUVODLDDJR|UxRTBwM{Wgcm0> M3j3OlE4OTV2NUC1
A2780-cell M2Dvcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnG4R49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IFGyO|gxNWOnbHyg[5Jwf3SqIHL5JFUxLSxiSVO1NF0xNjV3IH7N NVjOSHNzQTdyM{S3NS=>
G-361 cell NF3qTWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXUTZdEgXSxdH;4bYMheG:2ZX7jfUBz\XG3aYLl[EB1dyCrbnjpZol1KEdvM{[xJINmdGxiZ4Lve5RpKGK7IEWwKUwhUUN3ME2wMlY2KG6P NX3TTI83QTN5MUK0NC=>
human HL60 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 NYTHV4Y5PzJiaB?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjVibl2= NWGy[2xUOjJ7NESxNlE>
human K562 cells MYHDfZRwfG:6aXPpeJkh[XO|YYm= NWfKNWpvPSCmYYnz M2X0cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOUBl[Xm|IHL5JHhVXCCjc4PhfUwhUUN3ME2yMlYhdk1? MX:xPFA4PjF2MB?=
CH1 cell Ml3rR5l1d3SxeHnjbZR6KGG|c3H5 NVz2SJV7S3m2b4TvfIlkKHCxdHXuZ5khemWzdXny[YQhfG9iaX7obYJqfCCFSEGgZ4VtdCCpcn;3eIgh[nliNUClMEBKSzVyPUKuOlUhdk1? MXG5N|cyOjRy
MES-SA cells M{fHXXBzd2yrZnXyZZRqd25iYYPzZZk> M4G4SlczKGh? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3FV{1USSClZXzsd{BjgSCPVGSgZZN{[XliYX\0[ZIhPzJiaILzMEBKSzVyPUOgcm0> M1SzelE3QDJ2N{Wx
A549 cells Mkm4SpVv[3Srb36gZZN{[Xl? MWnBZ5Rqfmm2eTDh[4FqdnO2IFG1OFkh[2GwY3XyJINmdGxibHnu[UwhUUN3ME2zMlEhdk1? M33HdVg6PjB3NUi=
LoVo cells M2HVZWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4rmd|E1PCCq M{C4PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxwXm9iY3HuZ4VzKGOnbHygcIlv\SC5YYOg[IV1\XKvaX7l[EBi\nSncjCxOFQhcHJuIFnDOVA:Oy5|IH7N NWPzZYloOTV2NU[yOlg>
P388 cells Mmr3VJJwdGmoZYLheIlwdiCjc4PhfS=> NEfYRldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JHA{QDhiY3XscJMh[nliRVzJV2EtKEmFNUC9OE4{KG6P Mn3ENVcyPTR3MEW=
human Daudi cells M2TI[HBzd2yrZnXyZZRqd25iYYPzZZk> MnOxO|IhcA>? NH3JfoVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTheYRqKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NTDuUS=> MWiyOVk6QDVyNB?=
SKOV-3 cell NUDaZVVXS3m2b4TvfIlkcXS7IHHzd4F6 M1rsZmN6fG:2b4jpZ{Bxd3SnbnP5JJJmeXWrcnXkJJRwKGmwaHnibZQhW0uRVj2zJINmdGxiZ4Lve5RpKDVyJTygTWM2OD13LkOgcm0> MXu5N|cyOjRy
OVCAR-3 cell NUC5WoZCTnWwY4Tpc44h[XO|YYm= M2\UTmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIH;2ZZJq[W5iT2\DRXIuOyClZXzsJIxqdmW|LDDJR|UxRTVwODDuUS=> MWG4PVYxPTV6
human MES-SA cells M3TYTHBzd2yrZnXyZZRqd25iYYPzZZk> NVrjXXpNPzJiaB?= M2DhNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVXTMXNCKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NjDuUS=> MV2yOVk6QDVyNB?=
PC3 cancer cell MV;DfZRwfG:6aXPpeJkh[XO|YYm= NYTFU3JSOTR2IHi= MmToR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOjbnPldkBk\WyuIHzpcoUhf2G|IHTleIVzdWmwZXSgZYZ1\XJiMUS0JIhzNCCLQ{WwQVchdk1? MorBNVU1PTZ{Nki=
MXF7 breast cell NHzidodHfW6ldHnvckBie3OjeR?= MV7BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCvYX3tZZJ6KGOjcnPpco9u[SC|ZX7zbZRqfmViTWjGO{BjemWjc4SgZ4VtdCCuaX7lMEBKSzVyPUiuO{BvVQ>? MWS4PVYxPTV6
HT-29 cell MXrDfZRwfG:6aXPpeJkh[XO|YYm= MYCxOFQhcA>? NFrTPXBEgXSxdH;4bYMheG:2ZX7jfUBz\XG3aYLl[EB1dyCrbnjpZol1KEiWLUK5JINmdGxiZ4Lve5RpKGK7IEWwKUBi\nSncjDj[YxtKGS{dXegZ49vfGGldDDmc5IhOTR2IHjyd{whUUN3PUCuNFEh|ryP MkHSPVM4OTJ2MB?=
HEK293 cells MmLnR5l1d3SxeHnjbZR6KGG|c3H5 MWC3NkBp M4DDTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwMEGg{txO M1;F[lI1PjFzOEmz
MKN45 cells MnzOR5l1d3SxeHnjbZR6KGG|c3H5 Mn[xNVQ1KGh? M4DpTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1MVjR3IHPhcoNmeiClZXzsJIxqdmVid3HzJIRmfGW{bXnu[YQh[W[2ZYKgNVQ1KGi{LDDJR|UxRTBwMEGyJO69VQ>? Mle3NVU1PTZ{Nki=
MES-SA cells NXnEOlRKS3m2b4TvfIlkcXS7IHHzd4F6 M4LTbFczKGh? Ml7IR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWVUNVODIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOTJizszN MYWyNVQ1PDJyNR?=
FM3 cells NUm3PHQ6WHKxbHnm[ZJifGmxbjDhd5NigQ>? NUfXVINSPzJiaB?= NV\WT3JtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDGUVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkCxN{DPxE1? MofPNlU6QTh3MES=
MCF-7 cells NFvZVmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGHMcXhKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6geJVud3JiY3XscEBtcW6nIF3DSk04KGK{ZXHzeEBi\GWwb3PhdoNqdm:vYTygTWM2OD1yLkCyJO69VQ>? Mo[4O|g2OzN2NR?=
human small-cell lung cancer NH63RWpEgXSxdH;4bYNqfHliYYPzZZk> MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDzcYFtdC2lZXzsJIx2dmdiY3HuZ4VzKCiVQ1zDLUwhUUN3ME2wMlAzKM7:TR?= NWrtTmJNQDJ3OEizOS=>
human HCT116 cells M3jjN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVG3NkBp MmrYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjJizszN M3XxUFIyPDR2MkC1
human HCT116 cells NHHJUGlRem:uaX\ldoF1cW:wIHHzd4F6 M2e4UVczKGh? NIf0U|NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFI2KM7:TR?= NWnlOIZYOjV7OUi1NFQ>
NCI-H460 cells NW\EOo15S3m2b4TvfIlkcXS7IHHzd4F6 M2DLR|Q5KGh? M3LrT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJIF{e2G7LDDFR|UxRTBwMEOg{txO MXuyN|k5QDN3MR?=
CCRF-CEM cells M1rkOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVHIN2ltPDhiaB?= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDR3JHNUOHTTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[2WubITpeIVzNWKudXWgZZN{[XluIFnDOVA:OC5yM{[g{txO M{\mdFIzPTh{OUmx
HeLa cells MkLmVJJwdGmoZYLheIlwdiCjc4PhfS=> MXO3NkBp MlW2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yNESg{txO Mn7uNlU6QTh3MES=
NCI60 cells M2XRZ2Z2dmO2aX;uJIF{e2G7 MYK0PEBp MojYRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJOlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OD12Nz64OkBvVQ>? M2fhVFE5PzF3N{i2
UACC375 cell NXO1R3AzTnWwY4Tpc44h[XO|YYm= MXfBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCvZXzhco9u[SCXQVPDN|c2KGOnbHygcIlv\SxiSVO1NF0xNjB2ODFOwG0> NUnyWGQ1QDl4MEW1PC=>
HT1080 cell Mo\US5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXTTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIT1cY9zKGOnbHygcIlv\SCKVEGwPFAtKEmFNUC9NE4xPjZizszN NVm0XYg3Pzh3M{O0OS=>
MES-SA/Dx5 cells MlWxVJJwdGmoZYLheIlwdiCjc4PhfS=> NVXIXlA5PzJiaB?= M4nOfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVXTMXNCN0S6NTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODd|IN88US=> NY\zcXJ6OjV7OUi1NFQ>
SF268 cells M4exUHBzd2yrZnXyZZRqd25iYYPzZZk> MVy0PEBp MmfpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVRkK2PEBk\WyuczDh[pRmeiB2ODDodpMtKEWFNUC9NE4{OiEQvF2= M4TySVI{Ozl3NkW2
KB/HeLa cells NUfwUHhRWHKxbHnm[ZJifGmxbjDhd5NigQ>? NF\B[|c1QCCq M2PBSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1KvTIVN[SClZXzsd{Bi\nSncjC0PEBpenNuIFXDOVA:OC5|NjFOwG0> NGnBW20zOzN7NU[1Oi=>
K562 cells MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHzxRWE4OiCq NHfFS|lIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNibXX0bI9lNCCLQ{WwQVAvPDJizszN NHzBWXkyQDJ3OES0Ni=>
MDA-MB-231 cells NFzGPXBRem:uaX\ldoF1cW:wIHHzd4F6 NELVOFk4OiCq M{Ppe2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDXV3QuOSCvZYToc4Qh[W[2ZYKgO|IhcHK|LDDJR|UxRTBwOU[g{txO MXWxO|M{PTF6OR?=
SF268 cells M4PmfmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXO0PEBp MkfVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzPjhiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlk4KM7:TR?= MYixO|k3OjB{OB?=
HCT116 cells MlHXR5l1d3SxeHnjbZR6KGG|c3H5 M4HlS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;Mz65OkDPxE1? NYDMSI5jOjB7NUG1PFI>
U937 cells MlXRR5l1d3SxeHnjbZR6KGG|c3H5 NYPKUXBDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTl|NzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;Nj6yJO69VQ>? MWCxPVYyPTlyMB?=
HepG2 cells MXTQdo9tcW[ncnH0bY9vKGG|c3H5 MXe0PEBp NIPL[ItCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUGuNFUh|ryP M4HteFI1Pzl2N{S3

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ROS1 / ROS1 / p-STAT3 / STAT3 / p-AKT / AKT / p-ERK / ERK; 

PubMed: 30108778     


Mechanism of action of mitoxantrone in HCC78 cells. Immunoblot analysis of p-ROS1, ROS1, p-STAT3, STAT3, p-AKT, AKT, p-ERK, ERK and GAPDH in HCC78 cells, cells were harvested after treatment with mitoxantrone for 48 h.

30108778
Growth inhibition assay
Cell number; 

PubMed: 24349321     


LNCaP 104-S, 104- R1, 104-R2, PC-3, and DU-145 cells were treated with increasing concentrations of mitoxantrone for 72 hrs. Relative cell number of LNCaP cells was determined by Hoechst dye 33258-based 96-well proliferation assay. Cell numbers were normalized to control (dimethylsulfoxide) of each cell line. Triple asterisks (***) represent statistically significant difference p < 0.001between the treated group and the control group.

24349321
In vivo Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. [4] Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand. [5]

Protocol

Solubility (25°C)

In vitro DMSO 89 mg/mL (172.01 mM)
Water 89 mg/mL (172.01 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 517.4
Formula

C22H29ClN4O6.2HCl

CAS No. 70476-82-3
Storage powder
in solvent
Synonyms NSC-301739

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02131688 Unknown status Drug: Mitoxantrone Hydrochloride Liposome Malignant Lymphoma CSPC ZhongQi Pharmaceutical Technology Co. Ltd. May 2013 Phase 1
NCT01701375 Terminated Drug: PD 0332991 Relapsed Acute Leukemia|Refractory Acute Leukemia|High-Risk Myelodysplasia Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|The Leukemia and Lymphoma Society|Pfizer September 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID