Catalog No.S7215 Synonyms: GW856553, GSK-AHAB
Molecular Weight(MW): 383.46
Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.
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Choose Selective p38 MAPK Inhibitors
|Description||Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.|
|In vivo||In spontaneously hypertensive stroke-prone rats (SHR-SP), Losmapimod significantly improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and subsequently attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1beta (IL-1beta). |
|In vitro||DMSO||76 mg/mL (198.19 mM)|
|Ethanol||41 mg/mL warmed (106.92 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
C22 H26 F N3 O2
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04004000||Recruiting||Drug: Losmapimod||Facioscapulohumeral Muscular Dystrophy 1||Fulcrum Therapeutics||August 23 2019||Phase 2|
|NCT04003974||Recruiting||Drug: Losmapimod|Drug: Placebo oral tablet||Facioscapulohumeral Muscular Dystrophy (FSHD)||Fulcrum Therapeutics||August 9 2019||Phase 2|
|NCT02000440||Completed||Drug: Losmapimod||Glomerulosclerosis Focal Segmental||GlaxoSmithKline||July 1 2014||Phase 2|
|NCT00976560||Completed||Drug: GW856553|Other: Placebo||Depressive Disorder Major||GlaxoSmithKline||September 25 2009||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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