Vinorelbine ditartrate (KW-2307)

Catalog No.S4269 Synonyms: Nor-5'-anhydrovinblastine ditartrate,KW-2307

For research use only.

Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.

Vinorelbine ditartrate (KW-2307) Chemical Structure

CAS No. 125317-39-7

Selleck's Vinorelbine ditartrate (KW-2307) has been cited by 25 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Other Microtubule Associated Products

Biological Activity

Description Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
Targets
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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EBC-1 NIi0T5FHfW6ldHnvckBie3OjeR?= MnrtSWJENTFiY3XscJMh\Gm|cHzhfYVlKGFibXHyb4VldHliaHnnbIVzKHKjdHWgc4Yh[2WubDDk[YF1cCC3cH;uJINieG2jdHnubYIhfHKnYYTt[Y51NCCjbHLlbZQhdm:2IILlZYNpcW6pIEGwNEUtKHeqZYLlZZMhfGinIHXm[oVkfCCrbjDOR2kuUDF7OUOge4F{KGyjcnflcJkhemW|dILpZ5Rm\CC2bzDpcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36= NVLzN3NVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C2O|Q2ODJpPkOwOlc1PTB{PD;hQi=>
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T-24 NVrDT|h6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnvKTY5pcWKrdHnvckBw\iCqdX3hckBVNTJ2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlI5PDJ3IN88UU4> MkjEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
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LP-1 NIHTNZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrJO4o1UW6qaXLpeIlwdiCxZjDoeY1idiCOUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjNzMUOyJO69VS5? MkO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
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DK-MG MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DqSmlvcGmkaYTpc44hd2ZiaIXtZY4hTEtvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFYvPDR3MU[g{txONg>? MnPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
NCI-H1693 M1nVZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{TOPGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlk{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB5Lki5OVcyKM7:TT6= MoXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
JVM-2 MnHDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\PZWRtUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hQC5|OUe3PUDPxE1w NHjK[nA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNyMkWvK|5USU6JRWK8M4E,
MSTO-211H MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVnSZYQ4UW6qaXLpeIlwdiCxZjDoeY1idiCPU2TPMVIyOUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEiuPFAxPDJizszNMi=> Mof4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
UACC-812 MoLGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW[zXFFIUW6qaXLpeIlwdiCxZjDoeY1idiCXQVPDMVgyOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iOD65NVM2PSEQvF2u MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMxOjVxJ{7TRW5ITVJ:L3G+
CW-2 M2Xtc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHjTY5pcWKrdHnvckBw\iCqdX3hckBEXy1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC5MlMzPDl2IN88UU4> NIC5Rlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNyMkWvK|5USU6JRWK8M4E,
NCI-H1155 NVTOWXRCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3PpeWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB7Lk[zNFg2KM7:TT6= M{jQSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2OzB{NT:nQnNCVkeHUkyvZV4>
NCI-H720 NVfGZoU1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\kNGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFyLkm1OFIh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMxOjVxJ{7TRW5ITVJ:L3G+
P31-FUJ MkP5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mnm4TY5pcWKrdHnvckBw\iCqdX3hckBROzFvRmXKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyOS5|OEW4JO69VS5? NHe0Omc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNyMkWvK|5USU6JRWK8M4E,
TALL-1 NVeyZZIyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmjCTY5pcWKrdHnvckBw\iCqdX3hckBVSUyOLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFEyNjh5MUSg{txONg>? NWLPWFFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|MEK1M{c,W0GQR1XSQE9iRg>?
NCI-H1838 MmHaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnvETY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG4N|gh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF{LkKzOFgh|ryPLh?= NXrHT5JmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|MEK1M{c,W0GQR1XSQE9iRg>?
Assay
Methods Test Index PMID
Western blot Cyclin A / Cyclin B1 / p-Histone H3 / CDK1 / PCNA 19017359
Immunofluorescence RPS6 / G3BP1 / TIAR ; G3BP1 / eIF3b / eIF4G 27083003
Growth inhibition assay Cell number 19017359
In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]

Protocol (from reference)

Animal Research:[5]
  • Animal Models: Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
  • Dosages: ~10 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 1079.11
Formula

C45H54N4O8.2C4H6O6

CAS No. 125317-39-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04896320 Recruiting Drug: Tucatinib Breast Cancer Stage IV Providence Health & Services|Seagen Inc. December 15 2021 Phase 1|Phase 2
NCT04299113 Recruiting Drug: Vinorelbine|Drug: Mocetinostat Rhabdomyosarcoma Jonsson Comprehensive Cancer Center|Mirati Therapeutics Inc.|Phase One Foundation May 14 2020 Phase 1
NCT03891173 Terminated Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine Lung Adenocarcinoma Helix BioPharma Corporation|KCR S.A. February 19 2019 Phase 2
NCT02925000 Completed Drug: TLC178 Cancer Taiwan Liposome Company June 19 2017 Phase 1|Phase 2
NCT02658084 Terminated Drug: Vinorelbine|Drug: Trastuzumab Emtansine Breast Cancer|Metastatic Breast Cancer University of Miami|Genentech Inc. April 12 2017 Phase 1|Phase 2
NCT02768415 Unknown status Drug: Apatinib|Drug: Oral Vinorelbine Breast Cancer Cancer Institute and Hospital Chinese Academy of Medical Sciences June 2016 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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