Vinorelbine ditartrate (KW-2307)

Catalog No.S4269 Synonyms: Nor-5'-anhydrovinblastine ditartrate

For research use only.

Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.

Vinorelbine ditartrate (KW-2307) Chemical Structure

CAS No. 125317-39-7

Selleck's Vinorelbine ditartrate (KW-2307) has been cited by 25 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Other Microtubule Associated Products

Biological Activity

Description Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
Targets
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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EBC-1 NGHHVGdHfW6ldHnvckBie3OjeR?= NWHncoJYTUKFLUGgZ4VtdHNiZHnzdIxigWWmIHGgcYFzc2WmbImgbIlocGW{IILheIUhd2ZiY3XscEBl\WG2aDD1dI9vKGOjcH3heIlvcWJidILlZZRu\W62LDDhcIJmcXRibn;0JJJm[WOqaX7nJFExOCVuIIfo[ZJm[XNidHjlJIVn\mWldDDpckBPS0lvSEG5PVMhf2G|IHzhdodmdHlicnXzeJJq[3SnZDD0c{BqdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44> NG\nRZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|ME[3OFUxOid-M{C2O|Q2ODJ:L3G+
NCI-H1993 M{TiUWZ2dmO2aX;uJIF{e2G7 MkCzeIhmKHKjdHWgc4Yh[2WubDDk[YF1cCC3cH;uJINieG2jdHnubYIhfHKnYYTt[Y51KHejczDsZZJo\Wy7IILld5RzcWO2ZXSgeI8hcW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9v M4ntbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNke0OVAzLz5|ME[3OFUxOjxxYU6=
SCC114 M17TZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkPpO|IhcHK| MkTURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDlfJBwdmWwdHnhcIx6KGe{b4fpcoch[WSqZYLlcpQhcHWvYX6gV2NEOTF2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBtfW2rbnXzZ4Vv[2ViZHX0[YN1cW:wIHLhd4VlKEGWUHzpeIUh[XO|YYmsJGlEPTBiPTCwMlAxODB5IN88UU4> MmPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{K5PFQoRjJ3OEeyPVg1RC:jPh?=
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NCI-H1693 NIL1RodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGHN[FRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY6OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNz64PVU4OSEQvF2u M2fJPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2OzB{NT:nQnNCVkeHUkyvZV4>
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UACC-812 M2DFUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHVCS0NvOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA5NjlzM{W1JO69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMxOjVxJ{7TRW5ITVJ:L3G+
CW-2 M1;1e2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37udGlvcGmkaYTpc44hd2ZiaIXtZY4hS1dvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gPU4{OjR7NDFOwG0v NWf2TJJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|MEK1M{c,W0GQR1XSQE9iRg>?
NCI-H1155 NH20em1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fn[2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB7Lk[zNFg2KM7:TT6= NFWyRmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNyMkWvK|5USU6JRWK8M4E,
NCI-H720 NVj4Z|NvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyOC57NUSyJO69VS5? M2jwc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2OzB{NT:nQnNCVkeHUkyvZV4>
P31-FUJ NEfzZoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1K4N2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNzLV\VTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTFwM{i1PEDPxE1w Mm\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{ODJ3Lze+V2FPT0WUPD;hQi=>
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NCI-H1838 MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NITD[|VKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVg{QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUKuNlM1QCEQvF2u NXXXSIp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|MEK1M{c,W0GQR1XSQE9iRg>?
Assay
Methods Test Index PMID
Western blot Cyclin A / Cyclin B1 / p-Histone H3 / CDK1 / PCNA 19017359
Immunofluorescence RPS6 / G3BP1 / TIAR ; G3BP1 / eIF3b / eIF4G 27083003
Growth inhibition assay Cell number 19017359
In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]

Protocol (from reference)

Animal Research:[5]
  • Animal Models: Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
  • Dosages: ~10 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 1079.11
Formula

C45H54N4O8.2C4H6O6

CAS No. 125317-39-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04896320 Not yet recruiting Drug: Tucatinib Breast Cancer Stage IV Providence Health & Services|Seagen Inc. July 2021 Phase 1|Phase 2
NCT04299113 Recruiting Drug: Vinorelbine|Drug: Mocetinostat Rhabdomyosarcoma Jonsson Comprehensive Cancer Center|Mirati Therapeutics Inc.|Phase One Foundation May 14 2020 Phase 1
NCT03891173 Terminated Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine Lung Adenocarcinoma Helix BioPharma Corporation|KCR S.A. February 19 2019 Phase 2
NCT02925000 Completed Drug: TLC178 Cancer Taiwan Liposome Company June 19 2017 Phase 1|Phase 2
NCT02658084 Terminated Drug: Vinorelbine|Drug: Trastuzumab Emtansine Breast Cancer|Metastatic Breast Cancer University of Miami|Genentech Inc. April 12 2017 Phase 1|Phase 2
NCT02768415 Unknown status Drug: Apatinib|Drug: Oral Vinorelbine Breast Cancer Chinese Academy of Medical Sciences June 2016 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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