Vinorelbine Tartrate
For research use only.
Catalog No.S4269
20 publications

CAS No. 125317-39-7
Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Purity & Quality Control
Choose Selective Microtubule Associated Inhibitors
Biological Activity
Description | Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation. | |||||||||||||||||||||||||||||||||||||
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Features | A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug. | |||||||||||||||||||||||||||||||||||||
Targets |
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In vitro |
Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4] |
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Cell Data |
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Assay |
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In vivo | In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5] |
Protocol
Animal Research:[5] |
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Solubility (25°C)
In vitro | DMSO | 100 mg/mL (92.66 mM) |
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Water | 100 mg/mL warmed (92.66 mM) | |
Ethanol | 100 mg/mL warmed (92.66 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 1079.11 |
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Formula | C45H54N4O8.2C4H6O6 |
CAS No. | 125317-39-7 |
Storage |
powder in solvent |
Synonyms | N/A |
Smiles | CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O |
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) | ||||||||||
Dosage | mg/kg | Average weight of animals | g | Dosing volume per animal | ul | Number of animals | ||||
Step 2: Enter the in vivo formulation () | ||||||||||
% DMSO % % Tween 80 % ddH2O | ||||||||||
CalculateReset |
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: : mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL,)
Method for preparing in vivo formulation:Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80,mix and clarify, next add μL ddH2O,mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
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NCT04299113 | Recruiting | Drug: Vinorelbine|Drug: Mocetinostat | Rhabdomyosarcoma | Jonsson Comprehensive Cancer Center|Mirati Therapeutics Inc.|Phase One Foundation | May 14 2020 | Phase 1 |
NCT03891173 | Recruiting | Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine | Lung Adenocarcinoma | Helix BioPharma Corporation|KCR S.A. | February 19 2019 | Phase 2 |
NCT02925000 | Recruiting | Drug: TLC178 | Cancer | Taiwan Liposome Company | June 19 2017 | Phase 1|Phase 2 |
NCT02658084 | Terminated | Drug: Vinorelbine|Drug: Trastuzumab Emtansine | Breast Cancer|Metastatic Breast Cancer | University of Miami|Genentech Inc. | April 12 2017 | Phase 1|Phase 2 |
NCT02768415 | Active not recruiting | Drug: Apatinib|Drug: Oral Vinorelbine | Breast Cancer | Chinese Academy of Medical Sciences | June 2016 | Phase 2 |
NCT02619929 | Completed | Drug: Vinorelbine oral | Non-Small-Cell Lung Cancer|Breast Cancer | Pierre Fabre Pharma GmbH|Winicker Norimed GmbH | February 2016 | -- |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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