Molecular Weight(MW): 1079.11
Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
Cited by 8 Publications
5 Customer Reviews
Activity of vinorelbine in NSCLC cell lines in cell viability assay. Activity of vinorelbine NCI-H23, NCI-H460, and NCC44 cell lines in a Cell Titer Glo cell viability assay. Cells were treated with increasing drug concentrations from 0-10000 nM. The data are plotted as the mean % of control cells against the corresponding drug concentration.
Cynthia Bernia from McGill University. Vinorelbine Tartrate purchased from Selleck.
JQ1 and chemotherapeutics (vinorelbine, docetaxel, cisplatin and carboplatin) cooperate to induce apoptosis. MDA-MB-231 and HS578T were exposed to drugs alone and in combination with JQ1, at the indicated doses. Apoptosis was examined after 72 hours of treatment by flow cytometry using Annexin V/ PI staining as previously described.
Mol Cancer Ther, 2016, 15(8):1823-33.. Vinorelbine Tartrate purchased from Selleck.
PyMT:Irs-2−/− cells transfected with empty vector (Irs2−/−) or IRS2 (Irs2−/−:IRS2) were treated with DMSO, 1 μm nocodazole, 20 nm vinblastine (Vin), or 20 nm vinorelbine (Vino) for 1 h and then stimulated with IGF-1 (10 ng/ml) for 15 min.
J Biol Chem, 2017, 292(19):7806-7816. Vinorelbine Tartrate purchased from Selleck.
Combination drug treatment increased multinucleated giant cells via spindle microtubule alteration and cell cycle arrest. Immunofluorescent staining of BT-20 cell line after treatment with vinorelbine (NVB) or vinorelbine in combination with 5 μM of either ME0328 (NVB + ME) or olaparib (NVB + Olaparib) for 24 h. Cells were stained with Dapi for DNA (blue). α-tubulin for microtubules (green) and the merge with a 100× objective. Abundant multinucleated giant cells observed in cells treated with NVB + ME and NVB + Olaparib comparing with NVB alone.
Breast Cancer Res Treat, 2018, 172(1):23-32. Vinorelbine Tartrate purchased from Selleck.
Dose-response curves of vinorelbine. Cells and microtissues are treated with increasing doses of the anti-mitotic microtubuli inhibitor vinorelbine for 24 and 48 h. The response of 2D cultivated cells compared to microtissues was determined measuring intra-cellular ATP, LDH release and cell viability (*p < 0.05; n = 3 for ATP assay; n = 3–7 for LDH assay; n = 3–4 for flow cytometry)
J Cancer Res Clin Oncol, 2016, 142(9):1955-66. Vinorelbine Tartrate purchased from Selleck.
Purity & Quality Control
Choose Selective Microtubule Associated Inhibitors
|Description||Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.|
|Features||A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.|
Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.  Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. 
|In vivo||In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. |
-  Fellous A, et al. Semin Oncol. 1989, 16(2 Suppl 4), 9-14.
-  Photiou A, et al. J Cancer Res Clin Oncol. 1992, 118(4), 249-254.
-  Zhou YT, et al. Asian Pac J Cancer Prev. 2013, 14(8), 4635-4639.
|In vitro||DMSO||100 mg/mL (92.66 mM)|
|Water||100 mg/mL warmed (92.66 mM)|
|Ethanol||100 mg/mL warmed (92.66 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03891173||Recruiting||Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine||Lung Adenocarcinoma||Helix BioPharma Corporation|KCR S.A.||February 19 2019||Phase 2|
|NCT02925000||Recruiting||Drug: TLC178||Cancer||Taiwan Liposome Company||June 19 2017||Phase 1|Phase 2|
|NCT02658084||Terminated||Drug: Vinorelbine|Drug: Trastuzumab Emtansine||Breast Cancer|Metastatic Breast Cancer||University of Miami|Genentech Inc.||April 12 2017||Phase 1|Phase 2|
|NCT02768415||Active not recruiting||Drug: Apatinib|Drug: Oral Vinorelbine||Breast Cancer||Chinese Academy of Medical Sciences||June 2016||Phase 2|
|NCT02619929||Completed||Drug: Vinorelbine oral||Non-Small-Cell Lung Cancer|Breast Cancer||Pierre Fabre Pharma GmbH|Winicker Norimed GmbH||February 2016||--|
|NCT02225470||Completed||Drug: E7389 (Eribulin Mesylate)|Drug: Vinorelbine injection||HER2-Negative Breast Cancer|Triple Negative Breast Cancer|Breast Cancer|Cancer of Breast|Breast Tumors||Eisai Co. Ltd.|Eisai Inc.||September 26 2013||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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