Vinorelbine Tartrate

Catalog No.S4269

Vinorelbine Tartrate Chemical Structure

Molecular Weight(MW): 1079.11

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

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2 Customer Reviews

  • JQ1 and chemotherapeutics (vinorelbine, docetaxel, cisplatin and carboplatin) cooperate to induce apoptosis. MDA-MB-231 and HS578T were exposed to drugs alone and in combination with JQ1, at the indicated doses. Apoptosis was examined after 72 hours of treatment by flow cytometry using Annexin V/ PI staining as previously described.

    Mol Cancer Ther, 2016, 15(8):1823-33.. Vinorelbine Tartrate purchased from Selleck.

    Activity of vinorelbine in NSCLC cell lines in cell viability assay. Activity of vinorelbine NCI-H23, NCI-H460, and NCC44 cell lines in a Cell Titer Glo cell viability assay. Cells were treated with increasing drug concentrations from 0-10000 nM. The data are plotted as the mean % of control cells against the corresponding drug concentration.


    Cynthia Bernia from McGill University. Vinorelbine Tartrate purchased from Selleck.

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Biological Activity

Description Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]

In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]


Animal Research:[5]
+ Expand
  • Animal Models: Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: ~10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (92.66 mM)
Water 100 mg/mL warmed (92.66 mM)
Ethanol 100 mg/mL warmed (92.66 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1079.11


CAS No. 125317-39-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03703427 Not yet recruiting Pathologic Residual Cancer Cells Zhiyong Yu|Shandong Cancer Hospital and Institute November 2018 Phase 2
NCT03442673 Recruiting Multiple Myeloma University Hospital Inselspital Berne September 17 2018 Phase 2
NCT03656393 Recruiting NSCLC|EGFR Shenzhen People''s Hospital August 31 2018 Phase 3
NCT03652857 Recruiting Advanced Non Squamous Non Small Cell Lung Cancer Yongchang Zhang MD|Hunan Province Tumor Hospital August 1 2018 Phase 1
NCT03456076 Recruiting Carcinoma Non-Small-Cell Lung Hoffmann-La Roche August 16 2018 Phase 3
NCT03618550 Recruiting Hodgkin Lymphoma|Relapsed or Refractory Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Merck Sharp & Dohme Corp. August 1 2018 Phase 2

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID