Vinorelbine Tartrate

Catalog No.S4269

Vinorelbine Tartrate Chemical Structure

Molecular Weight(MW): 1079.11

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

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Cited by 8 Publications

5 Customer Reviews

  • Activity of vinorelbine in NSCLC cell lines in cell viability assay. Activity of vinorelbine NCI-H23, NCI-H460, and NCC44 cell lines in a Cell Titer Glo cell viability assay. Cells were treated with increasing drug concentrations from 0-10000 nM. The data are plotted as the mean % of control cells against the corresponding drug concentration.

     

    Cynthia Bernia from McGill University. Vinorelbine Tartrate purchased from Selleck.

    JQ1 and chemotherapeutics (vinorelbine, docetaxel, cisplatin and carboplatin) cooperate to induce apoptosis. MDA-MB-231 and HS578T were exposed to drugs alone and in combination with JQ1, at the indicated doses. Apoptosis was examined after 72 hours of treatment by flow cytometry using Annexin V/ PI staining as previously described.

    Mol Cancer Ther, 2016, 15(8):1823-33.. Vinorelbine Tartrate purchased from Selleck.

  • PyMT:Irs-2−/− cells transfected with empty vector (Irs2−/−) or IRS2 (Irs2−/−:IRS2) were treated with DMSO, 1 μm nocodazole, 20 nm vinblastine (Vin), or 20 nm vinorelbine (Vino) for 1 h and then stimulated with IGF-1 (10 ng/ml) for 15 min.

    J Biol Chem, 2017, 292(19):7806-7816. Vinorelbine Tartrate purchased from Selleck.

    Combination drug treatment increased multinucleated giant cells via spindle microtubule alteration and cell cycle arrest. Immunofluorescent staining of BT-20 cell line after treatment with vinorelbine (NVB) or vinorelbine in combination with 5 μM of either ME0328 (NVB + ME) or olaparib (NVB + Olaparib) for 24 h. Cells were stained with Dapi for DNA (blue). α-tubulin for microtubules (green) and the merge with a 100× objective. Abundant multinucleated giant cells observed in cells treated with NVB + ME and NVB + Olaparib comparing with NVB alone.

    Breast Cancer Res Treat, 2018, 172(1):23-32. Vinorelbine Tartrate purchased from Selleck.

  • Dose-response curves of vinorelbine. Cells and microtissues are treated with increasing doses of the anti-mitotic microtubuli inhibitor vinorelbine for 24 and 48 h. The response of 2D cultivated cells compared to microtissues was determined measuring intra-cellular ATP, LDH release and cell viability (*p < 0.05; n = 3 for ATP assay; n = 3–7 for LDH assay; n = 3–4 for flow cytometry)

    J Cancer Res Clin Oncol, 2016, 142(9):1955-66. Vinorelbine Tartrate purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
Targets
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
JEG3 NFfRc21E\WyuII\pZYJqdGm2eTDhd5NigQ>? NFTYd4IxNjBzLUGwNOKh|ryP M1G4cFQ5KGh? NUjqVo5bfmmwb4LlcIJqdmVic3nncolncWOjboTsfUBz\WS3Y3XkJGpGTzNiY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZItKGSxd36geI8h[SClb37j[Y51emG2aX;uJI9nKDBwMTFOwG0v NIrpSFgzQTR{OUi5NS=>
HTR-8/SVneo NX;2VpF2S2WubDD2bYFjcWyrdImgZZN{[Xl? NYr5[Gh7OC5yMT2xNFDDqM7:TR?= M4rPXlQ5KGh? Momxeolvd3KnbHLpcoUhe2mpbnnmbYNidnSueTDy[YR2[2WmIFjUVk05N3O4bnXvJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{LDDkc5dvKHSxIHGgZ49v[2WwdILheIlwdiCxZjCxJO69VS5? MXiyPVQzQTh7MR?=
EBC-1 NIXE[ZFHfW6ldHnvckBie3OjeR?= NV[4XYlGTUKFLUGgZ4VtdHNiZHnzdIxigWWmIHGgcYFzc2WmbImgbIlocGW{IILheIUhd2ZiY3XscEBl\WG2aDD1dI9vKGOjcH3heIlvcWJidILlZZRu\W62LDDhcIJmcXRibn;0JJJm[WOqaX7nJFExOCVuIIfo[ZJm[XNidHjlJIVn\mWldDDpckBPS0lvSEG5PVMhf2G|IHzhdodmdHlicnXzeJJq[3SnZDD0c{BqdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44> MorMN|A3PzR3MEK=
NCI-H1993 NYDxXmx1TnWwY4Tpc44h[XO|YYm= NYG4eVJjfGinIILheIUhd2ZiY3XscEBl\WG2aDD1dI9vKGOjcH3heIlvcWJidILlZZRu\W62IIfhd{Bt[XKpZXz5JJJme3S{aXP0[YQhfG9iaX7obYJqfGmxbjDv[kBxem:uaX\ldoF1cW:w NIm5cXo{ODZ5NEWwNi=>

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
Cyclin A / Cyclin B1 / p-Histone H3 / CDK1 / PCNA ; 

PubMed: 19017359     


When A498 and 786-O cells were treated with vinorelbine for 72 hrs and 48 hrs, respectively, increased Cyclin B1, phospho-histone H3, and Cdk1 were detected with doses of 100 nM and 10 nM of vinorelbine in A498 and 786-O tumours cells, respectively. In both cell lines, Cyclin A was decreased with a 1 μM dose. PCNA expression did not change with any treatments. In each case, β-Actin was used as a loading control.

19017359
Immunofluorescence
G3BP1 / eIF3b / eIF4G ; 

PubMed: 27083003     


U2OS cells were stressed with sodium arsenite (SA, 100 μM), vinorelbine (VRB, 150 μM), vinblastine (VBL, 300 μM), vincristine (VCR, 750 μM) and paclitaxel (PCX, 400 μM) for 1 hour. Unstressed U2OS cells (no drug) were used as control. After treatment, cells were stained for SG markers G3BP1 (green), eIF4G (blue, shown as gray), eIF3b (red) and scored. Boxed region is shown enlarged with colors separated below each image; merged signals shown as gray. Size bar represents 10 μm.

RPS6 / G3BP1 / TIAR ; 

PubMed: 27083003     


VRB-induced SGs contain mRNAs and 40S ribosomal subunits. U2OS WT cells stably expressing ribosomal protein S6 (RPS6) fused to GFP (GFP-RPS6) were stressed with vinorelbine (VRB, 150 μM) or left untreated (no drug) for 1 hour. Upper panel: Cells were visualized for GFP-RPS6 (green) or SG markers G3BP1 (red) and TIAR (blue, shown as gray). Lower panel: Cells were stained with SG markers G3BP1 (green) and TIAR (blue, shown as gray). In situ hybridization with oligo-dT40 probe against polyadenylated mRNAs (red) was done as described. Boxed region is shown enlarged with colors separated below each image. Size bar represents 10 μm.

27083003
Growth inhibition assay
Cell number ; 

PubMed: 19017359     


Effect of vinorelbine on A498 and 786-O invasion in vitro. The effect of vinorelbine on A498 and 786-O cells invasion was assayed after 24 hrs of treatment. A 10 nM dose of vinorelbine was sufficient to inhibit both A498 and 786-O cells invasion after 6 hrs (P < 0.01 compared to untreated cells). The values represent an average of three separate experiments. **, P < 0.01 (treated group versus control group).

19017359
In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]

Protocol

Animal Research:[5]
+ Expand
  • Animal Models: Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: ~10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (92.66 mM)
Water 100 mg/mL warmed (92.66 mM)
Ethanol 100 mg/mL warmed (92.66 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1079.11
Formula

C45H54N4O8.2C4H6O6
CAS No. 125317-39-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03891173 Recruiting Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine Lung Adenocarcinoma Helix BioPharma Corporation|KCR S.A. February 19 2019 Phase 2
NCT02925000 Recruiting Drug: TLC178 Cancer Taiwan Liposome Company June 19 2017 Phase 1|Phase 2
NCT02658084 Terminated Drug: Vinorelbine|Drug: Trastuzumab Emtansine Breast Cancer|Metastatic Breast Cancer University of Miami|Genentech Inc. April 12 2017 Phase 1|Phase 2
NCT02768415 Active not recruiting Drug: Apatinib|Drug: Oral Vinorelbine Breast Cancer Chinese Academy of Medical Sciences June 2016 Phase 2
NCT02619929 Completed Drug: Vinorelbine oral Non-Small-Cell Lung Cancer|Breast Cancer Pierre Fabre Pharma GmbH|Winicker Norimed GmbH February 2016 --
NCT02225470 Completed Drug: E7389 (Eribulin Mesylate)|Drug: Vinorelbine injection HER2-Negative Breast Cancer|Triple Negative Breast Cancer|Breast Cancer|Cancer of Breast|Breast Tumors Eisai Co. Ltd.|Eisai Inc. September 26 2013 Phase 3

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID