For research use only.
CAS No. 125317-39-7
Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Selleck's Vinorelbine Tartrate has been cited by 20 publications
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|Description||Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.|
|Features||A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.|
Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.  Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. 
|In vivo||In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. |
-  Fellous A, et al. Semin Oncol. 1989, 16(2 Suppl 4), 9-14.
-  Photiou A, et al. J Cancer Res Clin Oncol. 1992, 118(4), 249-254.
-  Zhou YT, et al. Asian Pac J Cancer Prev. 2013, 14(8), 4635-4639.
|In vitro||DMSO||100 mg/mL (92.66 mM)|
|Water||100 mg/mL warmed (92.66 mM)|
|Ethanol||100 mg/mL warmed (92.66 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
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Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04299113||Recruiting||Drug: Vinorelbine|Drug: Mocetinostat||Rhabdomyosarcoma||Jonsson Comprehensive Cancer Center|Mirati Therapeutics Inc.|Phase One Foundation||May 14 2020||Phase 1|
|NCT03891173||Recruiting||Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine||Lung Adenocarcinoma||Helix BioPharma Corporation|KCR S.A.||February 19 2019||Phase 2|
|NCT02925000||Recruiting||Drug: TLC178||Cancer||Taiwan Liposome Company||June 19 2017||Phase 1|Phase 2|
|NCT02658084||Terminated||Drug: Vinorelbine|Drug: Trastuzumab Emtansine||Breast Cancer|Metastatic Breast Cancer||University of Miami|Genentech Inc.||April 12 2017||Phase 1|Phase 2|
|NCT02768415||Active not recruiting||Drug: Apatinib|Drug: Oral Vinorelbine||Breast Cancer||Chinese Academy of Medical Sciences||June 2016||Phase 2|
|NCT02619929||Completed||Drug: Vinorelbine oral||Non-Small-Cell Lung Cancer|Breast Cancer||Pierre Fabre Pharma GmbH|Winicker Norimed GmbH||February 2016||--|
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