Nafamostat mesilate (FUT-175)

Catalog No.S1386

For research use only.

Nafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.

Nafamostat mesilate (FUT-175) Chemical Structure

CAS No. 82956-11-4

Selleck's Nafamostat mesilate (FUT-175) has been cited by 9 Publications

2 Customer Reviews

Purity & Quality Control

Choose Selective Serine Protease Inhibitors

Biological Activity

Description Nafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
Targets
serine protease [1]
In vitro

Nafamostat mesilate significantly inhibits the release of platelet beta-thromboglobulin (beta TG) at 60 and 120 min. Nafamostat mesilate (NM) prevents any significant release of neutrophil elastase; at 120 min, plasma elastase-alpha 1-antitrypsin complex is 0.16 mg/mL in the NM group and 1.24 mg/mL in the control group. Nafamostat mesilate completely inhibits formation of complexes of C1 inhibitor with kallikrein and FXIIa. [1] Nafamostat mesilate inhibits several proteases which may be importantly involved in the pathophysiology of disseminated intravascular coagulation (DIC).Nafamostat mesilate inhibits extrinsic pathway activity (TF-F.VIIa mediated-F.Xa generation) in a concentration dependent manner with IC50 of 0.1 μM. [2] Nafamostat mesilate produces concentration-dependent inhibition of the initial-phase transient component of biphasic ASIC3 currents with an IC50 value of approximately 2.5 mM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NS0 Mo\pSpVv[3Srb36gZZN{[Xl? MXKxOUBucW6| MonvTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDMZRmem2rbnHsJGhqezFyLYTh[4dm\CCqdX3hckBJ\XC|aX6gLHI1PSC2bzDMNVchemW|aXT1[ZMqKERzNkHFM{BTOTZ{SzDkc5VjdGVibYX0ZY51KGW6cILld5Nm\CCrbjDtc5V{\SCQU{CgZ4VtdHNidYPpcochSm:lLWHSVk1CVUNiYYOgd5Vje3S{YYTlJIFnfGW{IEG1JI1qdnNiYomgZZV1d22jdHXkJIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3ME2wMlAxPc7:TT6= M13qVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{CxPVYzLz5{OUewNVk3OjxxYU6=
Sf9 NGfJfVVHfW6ldHnvckBie3OjeR?= M17IdlMxKG2rboO= NH:1S2RKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCKR1\BJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|LXnu[oVkfGWmIGPmPUBk\WyuczD1d4lv\yCEb3OtVWxTNUGPQzDhd{B{fWK|dILheIUhcW6ldXLheIVlKG[xcjCzNEBucW6|IIDybY9zKHSxIIP1ZpN1emG2ZTDh[IRqfGmxbjDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEurPUCuNFI2|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6MkWyNEc,OjV6OEK1NlA9N2F-
Sf9 M3v2SmZ2dmO2aX;uJIF{e2G7 Ml;WN|AhdWmwcx?= MWDJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IF6teIVzdWmwYXygTIl{NXSjZ3fl[EBJT0[DIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{NWmwZnXjeIVlKFOoOTDj[YxteyCrbnP1ZoF1\WRiZn;yJFMxKG2rboOgdJJqd3JidH:gZ5JwdW:pZX7pZ{B{fWK|dILheIUh[WSmaYTpc44h[nlic4DlZ5Rzd3Cqb4TvcYV1enluIFnDOVA:OC5zNd88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6MkWyNEc,OjV6OEK1NlA9N2F-
MDA-MB-231 MVXGeY5kfGmxbjDhd5NigQ>? MVyxOUBucW6| MU\Jcohq[mm2aX;uJI9nKEiJRlGgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHOtUWVVKHCqb4PwbI9zgWyjdHnvckBi\nSncjCxOUBucW6|IHL5JIludXWwb3Lsc5R1cW6pLDDFR|UxRTBwNEpOwG0v MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTRyOEizOEc,OjV2MEi4N|Q9N2F-
In vivo

Nafamostat mesilate (10 mg/kg) inhibits scratching induced by tryptase but not by histamine and serotonin. Nafamostat mesilate (1-10 mg/kg) produces the dose-dependent inhibition of scratching induced by intradermal compound 48/80 (10 mg/site). Nafamostat mesilate (10 mg/kg) suppresses tryptase activity in the mouse skin. [4] Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB activation, enhances apoptosis by gemcitabine and suppresses pancreatic tumor growth. Nafamostat mesilate combined with Gemcitabine improves the body weight loss of mice induced by Gemicitabine. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 539.58
Formula

C19H17N5O2.2CH4O3S

CAS No. 82956-11-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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