GW441756

Catalog No.S2891

For research use only.

GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.

GW441756 Chemical Structure

CAS No. 504433-23-2

Selleck's GW441756 has been cited by 12 Publications

3 Customer Reviews

Purity & Quality Control

Choose Selective Trk receptor Inhibitors

Biological Activity

Description GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.
Targets
TrkA [1]
(Cell-free assay)
2 nM
In vitro

GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production[2] and apoptosis in TrkA-overexpressing cells. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 25 mg/mL
(90.81 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 275.3
Formula

C17H13N3O

CAS No. 504433-23-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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