BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

Size Price Stock Quantity  
In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 63 Publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NGLFXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fOVWlEPTB;MD6wNFc4PiEQvF2= MlHGV2FPT0WU
ACN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLEW2ZKSzVyPUCuNFA5PDNizszN MYfTRW5ITVJ?
TE-8 NYTsVnd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTqO25KSzVyPUCuNFA6PDFizszN M4O2THNCVkeHUh?=
LC-2-ad MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfxTWM2OD1yLkCxNFk{KM7:TR?= MYfTRW5ITVJ?
ALL-PO M4OxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH6S3IxUUN3ME2wMlAyOyEQvF2= M2LPUHNCVkeHUh?=
EW-16 M4S2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEGzN|Yh|ryP M1nhXHNCVkeHUh?=
KM12 M4DLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEGzOFgh|ryP MYDTRW5ITVJ?
GI-1 NHzoc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\wTWM2OD1yLkCxN|g{KM7:TR?= NGXr[IhUSU6JRWK=
LS-411N NImxSnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT4TWM2OD1yLkCxOFA4KM7:TR?= MYDTRW5ITVJ?
ES8 NWX2TplHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DlfmlEPTB;MD6wNVQ6PCEQvF2= MkPiV2FPT0WU
SNU-C2B MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;RTWM2OD1yLkCxOVI3KM7:TR?= M4HkbHNCVkeHUh?=
CESS M3\ST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjwV2NKSzVyPUCuNFE3ODJizszN NETnVHVUSU6JRWK=
697 NV3lPIdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTSfWQzUUN3ME2wMlAyPjZ6IN88US=> MV\TRW5ITVJ?
NCI-H1963 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfWWpFKSzVyPUCuNFE3PzNizszN Mkf4V2FPT0WU
IA-LM M1my[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEG2PFgh|ryP M3;y[3NCVkeHUh?=
SW954 NVTQdZVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j1SGlEPTB;MD6wNVcxPSEQvF2= NEP3SlFUSU6JRWK=
RL95-2 NVXYVHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTnUFloUUN3ME2wMlAyPzN6IN88US=> NIjKblRUSU6JRWK=
LXF-289 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojqTWM2OD1yLkCxO|ch|ryP Mn:1V2FPT0WU
OCUB-M Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEG4NlYh|ryP M2n0RnNCVkeHUh?=
RKO NF7nPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHmTWM2OD1yLkCxPVg4KM7:TR?= M2X2SHNCVkeHUh?=
LOUCY NFHVRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC4TWM2OD1yLkCyNFUh|ryP NUGwfmxwW0GQR1XS
NOS-1 NV\QN2lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7LbHlHUUN3ME2wMlAzODl|IN88US=> MUnTRW5ITVJ?
A4-Fuk MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfNT4lKSzVyPUCuNFIzOThizszN NU\qXI86W0GQR1XS
A388 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDCWFZKSzVyPUCuNFIzOjdizszN MYnTRW5ITVJ?
TE-9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHSOWdKSzVyPUCuNFIzPjFizszN MV\TRW5ITVJ?
KURAMOCHI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LtfmlEPTB;MD6wNlI5PSEQvF2= NEXGb3NUSU6JRWK=
KALS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITEd3NKSzVyPUCuNFI{OzhizszN MYDTRW5ITVJ?
HOP-62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILVVHBKSzVyPUCuNFI1OiEQvF2= MUTTRW5ITVJ?
RPMI-8402 NX;MPJhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fLdGlEPTB;MD6wNlUxQCEQvF2= NUDkV3JyW0GQR1XS
TE-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnxdI5KSzVyPUCuNFI2OTJizszN NV;1NpM4W0GQR1XS
CCRF-CEM M{XpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LJWmlEPTB;MD6wNlU1OyEQvF2= NGm3XnhUSU6JRWK=
HUTU-80 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13Pc2lEPTB;MD6wNlYzPCEQvF2= MYrTRW5ITVJ?
NCI-H1648 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPVTHd{UUN3ME2wMlAzPjR5IN88US=> M3u5R3NCVkeHUh?=
HCE-4 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fzZWlEPTB;MD6wNlY5OiEQvF2= MX\TRW5ITVJ?
ETK-1 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEK3N|Yh|ryP NVXRNWQ3W0GQR1XS
TE-15 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rCeWlEPTB;MD6wNlc{QCEQvF2= MV;TRW5ITVJ?
BE-13 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrNfpFKSzVyPUCuNFI4PCEQvF2= NILSRYtUSU6JRWK=
KE-37 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X6VmlEPTB;MD6wNlc1OSEQvF2= NXrSUphMW0GQR1XS
NCI-H1355 M4j5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEK3PFMh|ryP M3vsTnNCVkeHUh?=
TE-11 M{j2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEizU3lKSzVyPUCuNFI5ODlizszN MYHTRW5ITVJ?
BL-70 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzYTWM2OD1yLkCyPFU4KM7:TR?= NWi5cpM3W0GQR1XS
ES6 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEK4PFEh|ryP NVnwTHdlW0GQR1XS
GT3TKB MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEK5OVMh|ryP NV:wNlNDW0GQR1XS
LB647-SCLC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3RTWM2OD1yLkCzNVk2KM7:TR?= NEPqW3RUSU6JRWK=
NB13 NFfTc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEOzNVYh|ryP NYfPXVVJW0GQR1XS
ST486 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1iwPGlEPTB;MD6wN|M{PyEQvF2= MWLTRW5ITVJ?
NCI-H82 NFy5c5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy5blZKSzVyPUCuNFM{PDNizszN M2GxUHNCVkeHUh?=
NTERA-S-cl-D1 NILoVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\LOmlEPTB;MD6wN|M6QSEQvF2= NFPweZBUSU6JRWK=
ES4 M3;BbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILsTnBKSzVyPUCuNFM1PjNizszN NIXPZ3pUSU6JRWK=
SK-NEP-1 NIn6SolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLGTWM2OD1yLkCzOFk6KM7:TR?= M3vYSXNCVkeHUh?=
Becker M4PqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG5TWM2OD1yLkCzOVU2KM7:TR?= Mn7HV2FPT0WU
A101D NV3YS|Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v5c2lEPTB;MD6wN|c1QCEQvF2= NXzLZohZW0GQR1XS
SK-UT-1 M3S3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHPT|E6UUN3ME2wMlA{Pzd2IN88US=> M4[0RXNCVkeHUh?=
SW982 NEK2XW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3kOodKSzVyPUCuNFM4QSEQvF2= MXnTRW5ITVJ?
TE-10 M4C4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMESwOFYh|ryP MlLLV2FPT0WU
OVCAR-4 NILUZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofYTWM2OD1yLkC0NFU6KM7:TR?= NETHW3BUSU6JRWK=
KP-N-YS NHzkXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\PPGlEPTB;MD6wOFA5PSEQvF2= NHzyXZRUSU6JRWK=
BL-41 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rXZ2lEPTB;MD6wOFEzPSEQvF2= NWn1endZW0GQR1XS
MZ1-PC NFrndmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMESxNlch|ryP NWnnPVhzW0GQR1XS
PF-382 M1;MbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TObGlEPTB;MD6wOFE6QCEQvF2= Mo\xV2FPT0WU
MOLT-13 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[xb4x2UUN3ME2wMlA1OjN6IN88US=> MkW0V2FPT0WU
HCC1599 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;XTGFDUUN3ME2wMlA1OjV6IN88US=> NUC2RotxW0GQR1XS
IST-MEL1 NUDxfpNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHWSppIUUN3ME2wMlA1PDR{IN88US=> MWXTRW5ITVJ?
LU-139 NUHDUZBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\3TWM2OD1yLkC0OFQzKM7:TR?= MYDTRW5ITVJ?
MS-1 NEPjW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHWTWM2OD1yLkC0O|AyKM7:TR?= M1vUNnNCVkeHUh?=
MFH-ino NXXQSoJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEWwNFMh|ryP MlyzV2FPT0WU
IMR-5 NGfPXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\T[G5KSzVyPUCuNFUxOjFizszN MkWzV2FPT0WU
TE-5 M4\ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml30TWM2OD1yLkC1NFY{KM7:TR?= MoTiV2FPT0WU
DJM-1 NFq3O3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfr[mxKSzVyPUCuNFUyPDJizszN NGmxN3dUSU6JRWK=
NB17 NIrJZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEWyNFch|ryP MljiV2FPT0WU
KARPAS-45 M1i0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYridWdnUUN3ME2wMlA2OzV6IN88US=> NYHEOHZCW0GQR1XS
TGBC1TKB NI\UNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX4cVJKSzVyPUCuNFU1ODVizszN NWfScJliW0GQR1XS
ML-2 NEP5RZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLGTWM2OD1yLkC1OFE1KM7:TR?= MVjTRW5ITVJ?
no-10 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL2dZZlUUN3ME2wMlA2PDd2IN88US=> NV[zfY5tW0GQR1XS
CTV-1 NETD[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknRTWM2OD1yLkC1OVAzKM7:TR?= MWHTRW5ITVJ?
SJSA-1 NEjrWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXT[|BMUUN3ME2wMlA2PTJizszN MojZV2FPT0WU
HC-1 NH3LUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP1TWM2OD1yLkC1OVk4KM7:TR?= M3TtVnNCVkeHUh?=
TE-12 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfBTWM2OD1yLkC1OlE{KM7:TR?= M4nUeXNCVkeHUh?=
KY821 NUftUHJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi4ZnVGUUN3ME2wMlA2PjN{IN88US=> NHXOdJNUSU6JRWK=
TALL-1 M{ezWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfTTWM2OD1yLkC1O|A5KM7:TR?= NVjTV5JjW0GQR1XS
DEL M2L6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETxXWVKSzVyPUCuNFU4ODlizszN MkTZV2FPT0WU
TE-6 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LVUmlEPTB;MD6wOVczOiEQvF2= MmPYV2FPT0WU
SK-LMS-1 NUD4VGVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvSTWM2OD1yLkC1PFA2KM7:TR?= NX3ETlBkW0GQR1XS
EW-1 NX3zfnRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS1To81UUN3ME2wMlA2QDN5IN88US=> MWrTRW5ITVJ?
8-MG-BA MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TrSWlEPTB;MD6wOVg2OSEQvF2= NGjOZWtUSU6JRWK=
NALM-6 NHi3OpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fLS2lEPTB;MD6wOVk4OyEQvF2= MX3TRW5ITVJ?
LB771-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLvRY5KSzVyPUCuNFU6PzlizszN NFz1UoVUSU6JRWK=
HT-144 M4q5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TB[mlEPTB;MD6wOlE{KM7:TR?= MV3TRW5ITVJ?
KM-H2 NGXrSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwME[yNlEh|ryP NIXM[GFUSU6JRWK=
SF268 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH1R5FqUUN3ME2wMlA3Ojh4IN88US=> MkjaV2FPT0WU
RS4-11 M33jW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFraPYRKSzVyPUCuNFY{ODRizszN MX;TRW5ITVJ?
MHH-PREB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLIVodKSzVyPUCuNFY{OTlizszN MYHTRW5ITVJ?
ATN-1 NU[zTVY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHVTWM2OD1yLkC2N|Q2KM7:TR?= MoTvV2FPT0WU
BB30-HNC M120UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rmVGlEPTB;MD6wOlQ{PiEQvF2= Mlu2V2FPT0WU
CPC-N MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr5TWM2OD1yLkC2OVI1KM7:TR?= NE\JdGNUSU6JRWK=
NB1 NYHJWHJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M176NmlEPTB;MD6wOlYyOyEQvF2= MX\TRW5ITVJ?
KS-1 M2Prbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwME[3OFgh|ryP NWftTWtqW0GQR1XS
RXF393 NEH2ZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHWfmJwUUN3ME2wMlA3PzZ2IN88US=> NXfUeW1DW0GQR1XS
IST-SL2 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfaTWM2OD1yLkC3NFA1KM7:TR?= MVzTRW5ITVJ?
GI-ME-N MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPzV2RKUUN3ME2wMlA4Ojh4IN88US=> MmC2V2FPT0WU
VA-ES-BJ MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTsTWM2OD1yLkC3OFc2KM7:TR?= NFjzc3FUSU6JRWK=
NCI-H1581 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LmOmlEPTB;MD6wO|Q4QCEQvF2= NFuzUXlUSU6JRWK=
U-266 NUDTSndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;UPWZKSzVyPUCuNFc1QTdizszN M3HZcHNCVkeHUh?=
DMS-114 M{e1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEe1Nlgh|ryP MkPYV2FPT0WU
NCI-H187 NHXLWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\pflhsUUN3ME2wMlA4PzJ4IN88US=> M3H5cXNCVkeHUh?=
SW962 NE[2OVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEe4N|kh|ryP NFPuXJlUSU6JRWK=
MONO-MAC-6 NX3OcnRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjBUVRKSzVyPUCuNFc6QDZizszN MVzTRW5ITVJ?
MOLT-16 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;CTWM2OD1yLkC4NVIyKM7:TR?= NVf1PGdEW0GQR1XS
KNS-42 NUXIZZl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK5d4ZKSzVyPUCuNFgyPjFizszN MlPOV2FPT0WU
CMK MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnRVJRKSzVyPUCuNFgzOjVizszN NYDLOJVIW0GQR1XS
Ramos-2G6-4C10 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\0Z2lEPTB;MD6wPFIzPSEQvF2= NHzGWmZUSU6JRWK=
Daudi NEXt[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ITWJTUUN3ME2wMlA5OjV4IN88US=> NWTZeIlZW0GQR1XS
NCI-H510A MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEizN|Yh|ryP NHXvd5ZUSU6JRWK=
LB831-BLC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\BTWM2OD1yLkC4OVYyKM7:TR?= NWnLZYhIW0GQR1XS
HEL NVHZbJh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXzVXRjUUN3ME2wMlA5PjZ6IN88US=> MWLTRW5ITVJ?
LU-134-A NHfrUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEi3NFgh|ryP NXX3eYdtW0GQR1XS
NCI-H1694 NFzzbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTkTWM2OD1yLkC4O|Q1KM7:TR?= Mn62V2FPT0WU
KGN MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvxTWM2OD1yLkC4O|U6KM7:TR?= MWDTRW5ITVJ?
A253 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonqTWM2OD1yLkC4PFIzKM7:TR?= M2TnRnNCVkeHUh?=
DG-75 NYSydoMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVyzTIJoUUN3ME2wMlA5QTJ{IN88US=> MnPJV2FPT0WU
MOLT-4 M1\xTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3admdPUUN3ME2wMlA5QTh|IN88US=> NWLpe2dqW0GQR1XS
NCI-SNU-5 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEmyOVgh|ryP MkLQV2FPT0WU
ONS-76 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPpSYpKSzVyPUCuNFkzPzZizszN MoWwV2FPT0WU
NCI-H446 M3rJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LH[2lEPTB;MD6wPVQ3OiEQvF2= NYnR[W9YW0GQR1XS
COR-L279 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\JTWM2OD1yLkC5OVU3KM7:TR?= M1\qd3NCVkeHUh?=
Calu-6 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEm1PVgh|ryP NUDDPGhRW0GQR1XS
BC-3 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPqTWM2OD1yLkC5OlYzKM7:TR?= NEjHdmlUSU6JRWK=
NCI-H2126 NFLGNYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEm3PVEh|ryP M{j5WXNCVkeHUh?=
NCI-H1882 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEm4NFkh|ryP NIX6OIlUSU6JRWK=
BB65-RCC NXjQZY9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3IeXF6UUN3ME2wMlExOjl2IN88US=> MnOzV2FPT0WU
DU-4475 M3PyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUC0NFch|ryP M1P6NHNCVkeHUh?=
NCI-H526 NGKzWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHZTWM2OD1yLkGwOFQh|ryP MWjTRW5ITVJ?
NEC8 NF63WJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTZ[mdKSzVyPUCuNVA2OjVizszN NYT3eYdTW0GQR1XS
NCI-H1304 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMUC1PVQh|ryP M4HqSHNCVkeHUh?=
L-540 NFXlSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMUC3NFgh|ryP MmfhV2FPT0WU
NCI-SNU-16 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZTWM2OD1yLkGwO|QzKM7:TR?= MlfBV2FPT0WU
HD-MY-Z NWrZTJhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMUC4OVYh|ryP MofXV2FPT0WU
K-562 NUK0d2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMUC4OVgh|ryP M3j1W3NCVkeHUh?=
JAR NH72dpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMUC5NlUh|ryP NF3LNpBUSU6JRWK=
MZ2-MEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1njU2lEPTB;MD6xNVA2KM7:TR?= M13p[XNCVkeHUh?=
L-363 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHmTWM2OD1yLkGxNFc6KM7:TR?= NX[0VFZFW0GQR1XS
BV-173 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMUGyOFMh|ryP MmOyV2FPT0WU
NCI-H524 NHqx[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LjTmlEPTB;MD6xNVI4PCEQvF2= MkXvV2FPT0WU
EoL-1-cell Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f0V2lEPTB;MD6xNVY4OiEQvF2= NIexSnFUSU6JRWK=
K052 NF22VmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rqfGlEPTB;MD6xNVcyOiEQvF2= NHfE[XRUSU6JRWK=
TK10 NYO0[GFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMUG3Nlgh|ryP NGfxZ5FUSU6JRWK=
KU812 M2n5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLHS2E4UUN3ME2wMlEzODR2IN88US=> MlLkV2FPT0WU
RPMI-8226 NFTuWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfDOWZKSzVyPUCuNVIxPTJizszN NGLhdmhUSU6JRWK=
MZ7-mel M1nyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMUKyN|ch|ryP NFLjSmVUSU6JRWK=
SK-PN-DW MnuwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrnfndvUUN3ME2wMlEzOjh5IN88US=> NXvYPHJNW0GQR1XS
SR MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzrbIJKSzVyPUCuNVI1PDFizszN MXnTRW5ITVJ?
RPMI-6666 M2jnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G4NmlEPTB;MD6xNlc1OyEQvF2= MY\TRW5ITVJ?
no-11 NWLjSmVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3voZ2lEPTB;MD6xNlg3QSEQvF2= MV7TRW5ITVJ?
EW-3 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1THR2lEPTB;MD6xNlg6OyEQvF2= MYPTRW5ITVJ?
LAMA-84 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrSWmJTUUN3ME2wMlE{OTh5IN88US=> NGDCVY1USU6JRWK=
HT NFe5PZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDmTWM2OD1yLkGzOVc1KM7:TR?= M1z3c3NCVkeHUh?=
KP-N-RT-BM-1 M1TJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHMTWM2OD1yLkGzOlEzKM7:TR?= NVjSdoRkW0GQR1XS
NCI-H747 NFLoPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO1TWM2OD1yLkGzO{DPxE1? M4n2NHNCVkeHUh?=
NCCIT MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGezNXFKSzVyPUCuNVM6OzlizszN M{HFT3NCVkeHUh?=
MLMA NV;se5lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLmSIpKSzVyPUCuNVQyPjdizszN MY\TRW5ITVJ?
LP-1 NXG4W3hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorwTWM2OD1yLkG0NlQh|ryP MVzTRW5ITVJ?
CAL-148 NWXlZ4d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jDZWlEPTB;MD6xOFQ5OyEQvF2= NGPQenBUSU6JRWK=
GB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjyb4lmUUN3ME2wMlE1PTJ4IN88US=> M4nUSHNCVkeHUh?=
COR-L88 NYLOU5BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\ldHFKSzVyPUCuNVQ5ODJizszN NIrvTGJUSU6JRWK=
NKM-1 NXPvRXZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nnXWlEPTB;MD6xOFkxPiEQvF2= NUf6d|RNW0GQR1XS
NB5 M{Xqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzqN|ZKSzVyPUCuNVU1PjJizszN NYq4b4gyW0GQR1XS
SH-4 M{jReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMUW0OlYh|ryP NH60fHNUSU6JRWK=
EM-2 M3OzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfQOFZKUUN3ME2wMlE2PDZ5IN88US=> NWnmOnVOW0GQR1XS
TGBC24TKB M1\tWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLYTWM2OD1yLkG1OlU6KM7:TR?= Ml7LV2FPT0WU
SCLC-21H M{jkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm3N41JUUN3ME2wMlE2PzB{IN88US=> NVfQNXFuW0GQR1XS
COLO-684 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUW3NlEh|ryP MWrTRW5ITVJ?
KINGS-1 M4Hwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITVfIVKSzVyPUCuNVU6OSEQvF2= M2m0eHNCVkeHUh?=
LS-123 M1PsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL6d4FKSzVyPUCuNVU6OTdizszN MXfTRW5ITVJ?
MC116 MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle2TWM2OD1yLkG2NVU5KM7:TR?= NYHRcHJbW0GQR1XS
SU-DHL-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLNNIVvUUN3ME2wMlE3OjB4IN88US=> NUTCbm17W0GQR1XS
NCI-H64 M4S3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HwOmlEPTB;MD6xOlM1PyEQvF2= NW\wboIyW0GQR1XS
HCE-T NY\BWIxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zm[mlEPTB;MD6xOlUxPCEQvF2= MkHIV2FPT0WU
LOXIMVI MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nUdWlEPTB;MD6xOlk1QSEQvF2= M1zVR3NCVkeHUh?=
ARH-77 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTrNnZKSzVyPUCuNVc{PzlizszN M{[1SnNCVkeHUh?=
DOHH-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX2N5RYUUN3ME2wMlE4Pjd{IN88US=> MmHjV2FPT0WU
COLO-320-HSR NID2PW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMUixOVQh|ryP M1HYVXNCVkeHUh?=
NB6 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rnb2lEPTB;MD6xPFU3PiEQvF2= NV\5dI1RW0GQR1XS
L-428 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMUi4NVMh|ryP MYjTRW5ITVJ?
SNB75 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4naPWlEPTB;MD6xPFgzPCEQvF2= NHXCRnVUSU6JRWK=
NCI-H2141 NV71cVEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HJcWlEPTB;MD6xPVAyOSEQvF2= NH3ORnVUSU6JRWK=
KARPAS-299 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGSybG1KSzVyPUCuNVkzPDFizszN MUfTRW5ITVJ?
LC4-1 M{j1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\UOFdKSzVyPUCuNVk2ODJizszN NHTIR5VUSU6JRWK=
UACC-257 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP0e3VqUUN3ME2wMlE6QTR5IN88US=> NGrWXldUSU6JRWK=
EVSA-T MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfDbHY5UUN3ME2wMlIxOzF{IN88US=> NWjPOG5KW0GQR1XS
JiyoyeP-2003 NV7YS5lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMkC0O|ch|ryP NX7wNXVNW0GQR1XS
NCI-H720 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjVe2tKSzVyPUCuNlA2OjVizszN Mn\rV2FPT0WU
GAK NUXvXGtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMkGxPFkh|ryP MXTTRW5ITVJ?
HH NGrM[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j3PGlEPTB;MD6yNVQxPSEQvF2= NGPpPINUSU6JRWK=
NCI-H1436 NEPmPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHscWVPUUN3ME2wMlIyPDZ2IN88US=> NWfk[XA3W0GQR1XS
GR-ST NEnjWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrVelBKSzVyPUCuNlE1QDhizszN M3LjTnNCVkeHUh?=
BC-1 NGD1NmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMkK2NVYh|ryP MmnrV2FPT0WU
SIG-M5 NF;nfHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn60TWM2OD1yLkKyO|I4KM7:TR?= Mkf0V2FPT0WU
NCI-H345 M2SyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjGPXZuUUN3ME2wMlI{QDB3IN88US=> MYTTRW5ITVJ?
OPM-2 NEfs[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;3TpNGUUN3ME2wMlI{QDh{IN88US=> NUDhU|dxW0GQR1XS
LB1047-RCC M2TJPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nSO2lEPTB;MD6yOFQyKM7:TR?= M4PCT3NCVkeHUh?=
CTB-1 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonUTWM2OD1yLkK0OFk{KM7:TR?= MUTTRW5ITVJ?
A3-KAW MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LNbGlEPTB;MD6yOVM1OSEQvF2= MUfTRW5ITVJ?
SF126 M{T1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojjTWM2OD1yLkK1N|g{KM7:TR?= NHzBZZdUSU6JRWK=
KARPAS-422 NGOzbW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvGbIU5UUN3ME2wMlI2PDN3IN88US=> Ml\PV2FPT0WU
MEG-01 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK2bGNKSzVyPUCuNlU3PzNizszN NIXnPZhUSU6JRWK=
NCI-H209 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XkXGlEPTB;MD6yOlM4PCEQvF2= M3f1[3NCVkeHUh?=
SBC-1 NWnYSY9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TrZ2lEPTB;MD6yOlUh|ryP M4nIb3NCVkeHUh?=
K5 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S5ZWlEPTB;MD6yOlk5PCEQvF2= MojnV2FPT0WU
QIMR-WIL MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkexOVUh|ryP NX;I[5Q1W0GQR1XS
NMC-G1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrzRYx[UUN3ME2wMlI5OjF5IN88US=> M2fJPHNCVkeHUh?=
IST-MES1 NVu4[YtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzsZmJLUUN3ME2wMlI6OjN6IN88US=> NEDrVG1USU6JRWK=
SW684 NGDUeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r5TWlEPTB;MD6zNFA1PyEQvF2= NIDkN5FUSU6JRWK=
MV-4-11 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DxbGlEPTB;MD6zNFc5QCEQvF2= NHvMUYVUSU6JRWK=
LAN-6 NU\HT49oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvsUlM3UUN3ME2wMlMyPTd{IN88US=> NYLz[oJ3W0GQR1XS
RH-1 NHjKbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3aT4ZSUUN3ME2wMlMyQDdzIN88US=> Mn7yV2FPT0WU
CP66-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvVNpcyUUN3ME2wMlMyQDd6IN88US=> MWTTRW5ITVJ?
EC-GI-10 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XZNWlEPTB;MD6zNlk5PyEQvF2= NE\tb2xUSU6JRWK=
GDM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwM{OwOVkh|ryP NUP1RW9QW0GQR1XS
IST-SL1 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLyTWM2OD1yLkO0PVE1KM7:TR?= M2P5VXNCVkeHUh?=
KMOE-2 NGf0PYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULVSYRJUUN3ME2wMlM2OTd3IN88US=> NWfhcGw5W0GQR1XS
OS-RC-2 NFHrdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHRTWM2OD1yLkO1OVQ1KM7:TR?= M1vRZ3NCVkeHUh?=
HDLM-2 NUGxcoEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K4OGlEPTB;MD6zO|gyPCEQvF2= M4ny[HNCVkeHUh?=
DSH1 NX7UVJZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwM{i2N|Eh|ryP MVzTRW5ITVJ?
LS-1034 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojjTWM2OD1yLkO4PVU1KM7:TR?= NHXOVXdUSU6JRWK=
LB373-MEL-D MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwM{mxPVch|ryP MXTTRW5ITVJ?
GOTO NU\aPFBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILwdm1KSzVyPUCuOFIyOThizszN NYrwSFdbW0GQR1XS
MRK-nu-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwNEKyNFUh|ryP M2e4OnNCVkeHUh?=
SK-MM-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwNEO0OFIh|ryP Ml\NV2FPT0WU
BOKU MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwNEO3PVIh|ryP M3jYNnNCVkeHUh?=
NOMO-1 M2LSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm1Wox4UUN3ME2wMlQ{QDZizszN MUjTRW5ITVJ?
J-RT3-T3-5 M4O0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzaVIlvUUN3ME2wMlQ1QDd6IN88US=> M{fJfXNCVkeHUh?=
COLO-668 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnKTWM2OD1yLkS1OlY5KM7:TR?= NEDKOWZUSU6JRWK=
SF539 NHTpV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNEi2PFQh|ryP MV\TRW5ITVJ?
LB2518-MEL NU\qNpRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNEm3NFMh|ryP M1viR3NCVkeHUh?=
TE-441-T MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fmNmlEPTB;MD61NFEzKM7:TR?= MYDTRW5ITVJ?
MDA-MB-134-VI NXHDZ|Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XQ[2lEPTB;MD61NFkzOSEQvF2= Mkf6V2FPT0WU
SCC-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwNUG4O|Mh|ryP MYXTRW5ITVJ?
KLE MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwNUKxO|Eh|ryP NGPvNJVUSU6JRWK=
LB2241-RCC NYO4XI83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTpWXNFUUN3ME2wMlUzPTJ3IN88US=> MXTTRW5ITVJ?
NCI-H1417 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3oSnZKSzVyPUCuOVM1OzVizszN NF[0blhUSU6JRWK=
NCI-H2081 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwNUi2NVEh|ryP MUnTRW5ITVJ?
NCI-H1522 NWfzZWhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNUmzPFMh|ryP M2SydXNCVkeHUh?=
NCI-H889 NVXt[nVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zLdWlEPTB;MD61PVg1PCEQvF2= NF7LcYJUSU6JRWK=
CGTH-W-1 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jMWGlEPTB;MD62NFc2PSEQvF2= MlnjV2FPT0WU
EB-3 NFq1SJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHp[lVJUUN3ME2wMlYyOTV|IN88US=> M{\3UHNCVkeHUh?=
D-336MG M1\OXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwNkG3PVEh|ryP MYHTRW5ITVJ?
LC-1F MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvLTWM2OD1yLk[yOVkzKM7:TR?= MULTRW5ITVJ?
MHH-NB-11 M{nWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMOWlEPTB;MD62N|gxOSEQvF2= Mn;DV2FPT0WU
SK-N-FI NH;LcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHHTWM2OD1yLk[zPVEh|ryP NGX3S3lUSU6JRWK=
NCI-H69 MkPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNkS4O|kh|ryP MWDTRW5ITVJ?
SCH M4PnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNk[wNlMh|ryP M{XSTHNCVkeHUh?=
LS-513 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDTWmgxUUN3ME2wMlY4OjV7IN88US=> NV;G[VdrW0GQR1XS
CP67-MEL M3XXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfCcZBSUUN3ME2wMlY4PTl4IN88US=> MkTWV2FPT0WU
GCIY NXXmN5NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwN{CzOlMh|ryP MVrTRW5ITVJ?
SHP-77 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LVWmlEPTB;MD63NFc{PCEQvF2= NFPtXWpUSU6JRWK=
EHEB NH;oeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fEb2lEPTB;MD63NVg2PCEQvF2= NF3D[4dUSU6JRWK=
D-247MG NFnxO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i3[GlEPTB;MD63N|I{OiEQvF2= M1vvNnNCVkeHUh?=
Raji MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwN{S5PFkh|ryP MXnTRW5ITVJ?
MPP-89 NVPuPGlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPtb5JKSzVyPUCuO|U6PzhizszN M33hRXNCVkeHUh?=
EKVX M1Lacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLyb5dKSzVyPUCuO|kxPzNizszN NX3ZeYFnW0GQR1XS
HCC2218 NF:1cXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXITWM2OD1yLke5NVMyKM7:TR?= NYi1XmF5W0GQR1XS
KNS-81-FD MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jKWGlEPTB;MD64NVAyOSEQvF2= MXLTRW5ITVJ?
HCC2157 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[3T2VKSzVyPUCuPFQ6PTFizszN M12ycXNCVkeHUh?=
BT-474 NF;qc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwOEi4OVQh|ryP M4Pve3NCVkeHUh?=
NCI-H748 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwOUGyJO69VQ>? Mnm4V2FPT0WU
EW-24 NFHHcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwOUKwNFIh|ryP MmXMV2FPT0WU
D-263MG MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwOUS1NVIh|ryP MkDmV2FPT0WU
OMC-1 M3\TR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrvOVJkUUN3ME2wMlk3Ozd|IN88US=> NYj3S25LW0GQR1XS
NCI-H2196 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT4c4dCUUN3ME2wMlk4Pzd5IN88US=> NW\vVYRtW0GQR1XS
HAL-01 NEfQXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O0ZmlEPTB;MD65PVg4OiEQvF2= MoPXV2FPT0WU
NCI-H2107 M{PQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPWZ|FZUUN3ME2xMlAyQDV2IN88US=> NUK5SlFuW0GQR1XS
LB996-RCC NVv5R3JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fxTWlEPTB;MT6wPFA2OSEQvF2= MVHTRW5ITVJ?
NCI-H1395 NIDvcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTxTWM2OD1zLkGwOlch|ryP MlTlV2FPT0WU
CHP-126 NX;1d5pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPs[IxLUUN3ME2xMlE3OTl7IN88US=> M4LOe3NCVkeHUh?=
NB69 NWLTNmRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwMk[xOFgh|ryP Ml2yV2FPT0WU
CAS-1 M1Phemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHtRYxPUUN3ME2xMlM1OjNzIN88US=> MX3TRW5ITVJ?
JVM-3 NFS4[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G1PWlEPTB;MT60O|g2PSEQvF2= NFSzdllUSU6JRWK=
DMS-153 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTlWHI5UUN3ME2xMlU4Pjd2IN88US=> MmDaV2FPT0WU
SK-MEL-2 NYHLS|d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHXTWM2OD1zLkexO|g6KM7:TR?= M2fBT3NCVkeHUh?=
NCI-H1155 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\yXoJOUUN3ME2xMlc{Pjd4IN88US=> M1T4NHNCVkeHUh?=
NCI-H1092 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PkfWlEPTB;MT63OlE5OiEQvF2= NFvTTnZUSU6JRWK=
LU-165 NHLtTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjjTWM2OD1zLki2OFc3KM7:TR?= M1HZenNCVkeHUh?=
HL-60 NH3PbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX3[JRiUUN3ME2xMlk6QTB6IN88US=> MUDTRW5ITVJ?
REH MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3SmlEPTB;Mj6wNFU5OiEQvF2= NFLuOVhUSU6JRWK=
JVM-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zobmlEPTB;Mj6wOlE{PSEQvF2= NVzPR4VzW0GQR1XS
MN-60 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HaUGlEPTB;Mj6xO|MxQCEQvF2= M324c3NCVkeHUh?=
SCC-15 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v0ZmlEPTB;Mj6yNFI4KM7:TR?= NFT0UWhUSU6JRWK=
SNU-C1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjxZW9IUUN3ME2yMlIyOzR|IN88US=> MnjiV2FPT0WU
SK-MEL-1 NFjnVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEOxSJhKSzVyPUKuN|IxPDdizszN M37BNHNCVkeHUh?=
TGW MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLX[XRKSzVyPUKuN|UxOjdizszN NYnXc4V5W0GQR1XS
CA46 NGWyXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2wTWM2OD1{Lke1PVY4KM7:TR?= MmjhV2FPT0WU
NCI-H23 NXjR[HNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqy[4lrUUN3ME2yMlgxPzlzIN88US=> NHnhWHlUSU6JRWK=
MMAC-SF NH\Xeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;DXlNbUUN3ME2yMlg3PjJ6IN88US=> M1;nXnNCVkeHUh?=
NCI-H2171 NXznXnRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfwTWM2OD1|LkCzOFQ5KM7:TR?= M{HYZnNCVkeHUh?=
A704 NFe4bo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XLeWlEPTB;Mz6xOFE6PCEQvF2= NH3Xd|JUSU6JRWK=
DB M3vEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\JcGlEPTB;Mz6yOVU4PiEQvF2= NEfnXWxUSU6JRWK=
NCI-H719 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TQVWlEPTB;Mz6zNFM5PCEQvF2= MUnTRW5ITVJ?
MC-CAR NVrzN5plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[1NWlEPTB;Mz61OFgyPyEQvF2= MkXyV2FPT0WU
SIMA NHv3cotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKPXlDUUN3ME2zMlU5PDF4IN88US=> NI\rVVVUSU6JRWK=
SW872 M1\jOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;2UG8{UUN3ME2zMlc5OTBzIN88US=> MUHTRW5ITVJ?
HCC1187 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XW[mlEPTB;Mz63PFMyPSEQvF2= M4DibXNCVkeHUh?=
EW-13 M1HNVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfnTWM2OD1|LkizOFE4KM7:TR?= NVS0bnRFW0GQR1XS
NCI-SNU-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTRwMkG5PVkh|ryP NG\UeJdUSU6JRWK=
NCI-H226 NEjrN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GxOWlEPTB;ND6zN|YxPiEQvF2= MlLEV2FPT0WU
RPMI-8866 M2PIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO3TWM2OD12LkO2NFI6KM7:TR?= M1PZdHNCVkeHUh?=
OCI-AML2 NHjON|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LjPWlEPTB;ND61OVI{KM7:TR?= NYGybnA{W0GQR1XS
LU-65 M1nKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLkS|RVUUN3ME20Mlk{ODN|IN88US=> M2mzUXNCVkeHUh?=
SK-N-DZ NYTkWphOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTVwNkO0OlUh|ryP NFfZdJRUSU6JRWK=
NB14 M2mwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF71UJNKSzVyPUWuPVcyOzVizszN M4H3TXNCVkeHUh?=
COLO-829 NH\mN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXPSZNHUUN3ME22MlM{OzV7IN88US=> M2[wR3NCVkeHUh?=
MHH-CALL-2 NIHk[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrKOmFKSzVyPU[uOVE2ODhizszN NWnoU5FzW0GQR1XS
NCI-H1770 M{HRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrrU4FKSzVyPU[uOlY6ODRizszN NEjIfnBUSU6JRWK=
ECC4 M1TVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTIZ3g1UUN3ME22MlgzOTd7IN88US=> NV7xV2NKW0GQR1XS
A498 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLZO456UUN3ME22Mlg4OTl{IN88US=> NYfkb21ZW0GQR1XS
DMS-79 NIHGNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;oNmlzUUN3ME23MlA1PTF{IN88US=> MX3TRW5ITVJ?
P30-OHK NXLufWNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqxTWM2OD15LkKxPVA3KM7:TR?= NF\5NWVUSU6JRWK=
D-502MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DNcGlEPTB;Nz65PFM3KM7:TR?= MkTvV2FPT0WU
RCC10RGB Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRThwME[yPEDPxE1? Mo[4V2FPT0WU
U-698-M NH3hd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHNTWM2OD16LkK5NlI3KM7:TR?= M2raOHNCVkeHUh?=
BB49-HNC NYfLTpBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu1TWM2OD17LkSyNlY2KM7:TR?= NGjDO5hUSU6JRWK=
ES1 M4nMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjjW3dCUUN3ME25MlY5QTV4IN88US=> MWLTRW5ITVJ?
MFM-223 NYfZTm1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTFyLkm5Nlch|ryP M{LYfXNCVkeHUh?=
C2BBe1 NYLYVZBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jsNmlEPTB;MUGuN|UzOyEQvF2= MoCwV2FPT0WU
EB2 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qwWWlEPTB;MUKuOlg5OSEQvF2= M1u3WXNCVkeHUh?=
C8166 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXnTWM2OD1zMz64N|A{KM7:TR?= NXXLSnl[W0GQR1XS
ES3 MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofCTWM2OD1zMz65PVc4KM7:TR?= NUizeWd[W0GQR1XS
NCI-H1650 NHrse29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrnXndkUUN3ME2xOk4{PzZ3IN88US=> Ml\KV2FPT0WU
Mo-T MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXvS3BDUUN3ME2xO{41ODJ7IN88US=> NYfGfGQzW0GQR1XS
NB7 M1nT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLNTWM2OD1zNz63OFY4KM7:TR?= NVXYbJJMW0GQR1XS
ES7 M3e2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF7LkW1NFch|ryP M3GzRXNCVkeHUh?=
ES5 NGPnSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX6TWM2OD1{MT63OlcyKM7:TR?= MWPTRW5ITVJ?
MSTO-211H MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHKc4dKSzVyPUKxMlg5PThizszN M1HXdXNCVkeHUh?=
U-87-MG NXjsVnJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13RdGlEPTB;MkWuNVk3PiEQvF2= MX\TRW5ITVJ?
THP-1 NFvHbYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ7LkeyNFEh|ryP M3m2bnNCVkeHUh?=
NB10 NIOyRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNyLkK2PVQh|ryP M1jj[HNCVkeHUh?=
NH-12 Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSzTVdKSzVyPUOzMlIxOTdizszN MmPCV2FPT0WU
COLO-824 NGCwXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKxWnNWUUN3ME2zOE4yODB4IN88US=> NETXd2pUSU6JRWK=
SKM-1 NFfySVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvjTWM2OD1|Nz64OFIzKM7:TR?= NHLm[VhUSU6JRWK=
NCI-H1838 NX[4SXZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTN6LkO3PVch|ryP MWnTRW5ITVJ?
RL MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5e2lEPTB;M{muNlQ4PyEQvF2= MnjaV2FPT0WU
COLO-800 NHHWZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTRyLkC3O|Mh|ryP MYnTRW5ITVJ?
KG-1 M4T3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DsXGlEPTB;NECuPFk2PSEQvF2= NXX6VGkxW0GQR1XS
TUR M1\XfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTRzLk[zPVkh|ryP M13PSXNCVkeHUh?=
LNCaP-Clone-FGC NWXZWVd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TnVGlEPTB;NEGuPVAyPyEQvF2= MoDiV2FPT0WU
NCI-H322M M2rvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTR{LkW5PFQh|ryP MlrTV2FPT0WU
LNCaP  MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTlzLkOgcm0> NF\hOVIzPTVyNUG3OC=>
C4-2 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3vTWM2OD16IH7N NX;LZ2QyOjV3MEWxO|Q>
JURKAT NELqfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPZWnd1OjRiaB?= NXrMe2c6UUN3ME20NVYvPjZibl2= M13ES|I1PTF7OUm1
MOLT-4 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LPR|I1KGh? NG\uZlZKSzVyPUK4OVMvPSCwTR?= NUTqfHRMOjR3MUm5PVU>
REH MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4CybVI1KGh? MlWzTWM2OD1{OEeuOlghdk1? NHXmeG8zPDVzOUm5OS=>
NALM-6 M4DwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj4Xo9pOjRiaB?= NVXqOlJOUUN3ME2zOFM{OCCwTR?= MlTuNlQ2OTl7OUW=
RS 4;11 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfYVWpkOjRiaB?= NXi4enZEUUN3ME21NVkvODVibl2= MYCyOFUyQTl7NR?=
697 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYiyOEBp M{HzN2lEPTB;MkGwO{4yKG6P MViyOFUyQTl7NR?=
SIL-ALL NVXORYhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGyOEBp MYHJR|UxRTF7OT63O{BvVQ>? M33aNFI1PTF7OUm1
CEM M2rwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly4NlQhcA>? MWHJR|UxRTV{LkG4JI5O NWHofHBzOjR3MUm5PVU>
P12 NWPNfWpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KyXlI1KGh? M1WyW2lEPTB;M{muNlchdk1? MYKyOFUyQTl7NR?=
NALM-16 NHTMe|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXiyOEBp MYHJR|UxRTl4LkK4JI5O M3KyXVI1PTF7OUm1
JURKAT NVvTZnpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\YRlQ5KGh? M3HkbmlEPTB;MUSuPFQhdk1? MXSyOFUyQTl7NR?=
MOLT-4 NIjTV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13pdlQ5KGh? NF[0ZW1KSzVyPUK2MlYhdk1? M1:2OFI1PTF7OUm1
REH NE\BbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWm0PEBp MoTSTWM2OD12ND63NUBvVQ>? NXPYR4xoOjR3MUm5PVU>
NALM-6 MmO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLmcWd5PDhiaB?= MoCwTWM2OD1{Mz6yOkBvVQ>? NHHLe5YzPDVzOUm5OS=>
RS 4;11 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLGOFghcA>? MWnJR|UxRTF4ND6yPEBvVQ>? MonrNlQ2OTl7OUW=
697 MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS4OFghcA>? M4T2N2lEPTB;M{C1MlMhdk1? M3S4XlI1PTF7OUm1
SIL-ALL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\1Ro41QCCq MoX4TWM2OD15ND62NkBvVQ>? NYe4fodxOjR3MUm5PVU>
CEM NXjDXG9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrWTVg1QCCq Ml2yTWM2OD1{ND61OUBvVQ>? MV6yOFUyQTl7NR?=
P12 M3LOPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDUb5h{PDhiaB?= M{X0[2lEPTB;MUiuOFYhdk1? M{fWTlI1PTF7OUm1
NALM-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSzflM1QCCq NFT3eVRKSzVyPU[zMlI1KG6P NVLkU21uOjR3MUm5PVU>
JURKAT NU\JNIlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVq3NkBp M3WyS2lEPTB;Mz62OUBvVQ>? MYSyOFUyQTl7NR?=
MOLT-4 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD6V2l5PzJiaB?= M1j2ZmlEPTB;Nz6zPUBvVQ>? M3npZ|I1PTF7OUm1
REH MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\jO|IhcA>? MofJTWM2OD1zNj6wNUBvVQ>? M334OVI1PTF7OUm1
NALM-6 M4LWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm5V|V5PzJiaB?= M1S3fmlEPTB;MT63PEBvVQ>? NHPXWXYzPDVzOUm5OS=>
RS 4;11 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXu3NkBp M1\rS2lEPTB;ND6zPEBvVQ>? M4G2W|I1PTF7OUm1
697 NVf1NnFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[3NkBp M1jvPWlEPTB;N{SuNlghdk1? NHvwRoozPDVzOUm5OS=>
SIL-ALL M37vcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:3NkBp MoD1TWM2OD15LkKgcm0> M1q4U|I1PTF7OUm1
CEM MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWq3NkBp MYXJR|UxRTVwNEKgcm0> NWTmNlFIOjR3MUm5PVU>
P12 NHSwfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;z[II4OiCq M3fQ[mlEPTB;Nj6zO{BvVQ>? MmTZNlQ2OTl7OUW=
NALM-16 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfmbJNXPzJiaB?= NGjpXGpKSzVyPUe3Mlc{KG6P NUPV[IZPOjR3MUm5PVU>
Y79 MYTBdI9xfG:|aYOgRZN{[Xl? MYmxMVUxKG6P MkLwNVIwOjRiaB?= NF\oVG9FVVOR NVHYVIlrcW6mdXPl[EBieG:ydH;zbZMhf2irY3igZ4FvKGKnIHXubIFv[2WmIHL5JGhV M37GWFI1OzZ4Nk[1
WER-Rb-1 M3zEfWFxd3C2b4Ppd{BCe3OjeR?= NU\Pe5BNOS13MDDuUS=> M2XDPFEzNzJ2IHi= NG\H[HlFVVOR M3jrd4lv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=> Mk\zNlQ{PjZ4NkW=
G7 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjQV25KSzVyPUOuN{BvVQ>? M2HaTlI1OjB2N{Oz
G166 M{\NXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfMdphKSzVyPUeuNEBvVQ>? NXuwbG11OjR{MES3N|M>
CB660 NHPne3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XkcWlEPTB;Nj60JI5O MUKyOFIxPDd|Mx?=
CB1117 NV3xT5NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn1TIxKSzVyPUG1MlYhdk1? M3nrclI1OjB2N{Oz
KB-3-1 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfQd|lTUUN3ME2xMlQ5KMLzIECuOVMhdk1? M1fJZVI{QTZ{NES1
KB-8-5-11 NV3adGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDue4J5UUN3ME21MlAyKMLzIEKuNFEhdk1? MorBNlM6PjJ2NEW=
KB-C-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TZdWlEPTB;MU[uO|YhyrFiND61NUBvVQ>? NWjafG5NOjN7NkK0OFU>
KB-V-1 MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NYC3SoU3OjN7NkK0OFU>
OVCAR-8 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jmOWlEPTB;Nz6xPUDDuSB|Lk[wJI5O NVfDdVF1OjN7NkK0OFU>
NCI-ADR-RES M{HXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF{N{OuN|AhyrFiMUmxMlIxKG6P M4D1N|I{QTZ{NES1
MCF7 NXLWVW5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly3TWM2OD13LkGxJOKyKDFwNEegcm0> M17tTFI{QTZ{NES1
MCF7-FLV1000 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>? NIWxTpAzOzl4MkS0OS=>
S1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJ2LkOwJOKyKDRwN{Wgcm0> NIrTfmgzOzl4MkS0OS=>
S1-M1-80 NIDv[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnrVZI2UUN3ME2yOlEvODZiwsGgOFgvOjVibl2= M{\Pb|I{QTZ{NES1
CORL-23/P M1Xyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvQbGl3UUN3ME20MlM5KMLzIEGuNlUhdk1? NXHMUlZLOjN7NkK0OFU>
CORL-23/R M{fGPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDBe4JKSzVyPUWuNVYhyrFiMT64N{BvVQ>? MVeyN|k3OjR2NR?=
NIH3T3 NGrvO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjnRpVKSzVyPUSwMlYxKMLzIESuPVchdk1? NVvOdXlkOjN7NkK0OFU>
NIH3T3-G185 M2jrfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfTZ|J5UUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> NF:xN2MzOzl4MkS0OS=>
pcDNA-HEK293 M4D5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LENGlEPTB;Mj63OUDDuSByLk[3JI5O NH\mSnUzOzl4MkS0OS=>
MDR19-HEK293 M1v4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L2dGlEPTB;OEWuOVAhyrFiMUOuOlchdk1? NEDsO2kzOzl4MkS0OS=>
R482-HEK293 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXkTWM2OD1{NT65O{DDuSB2Lkm1JI5O MXmyN|k3OjR2NR?=
MRP1-HEK293 NIHKRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jYOWlEPTB;Mj65PUDDuSBzLkS5JI5O NHP3XIMzOzl4MkS0OS=>
SF188 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ex[|ExNTFyMDDuUS=> MYKyOE06PiCq MlTISG1UVw>? MX\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? NX\LdWZsOjN6OEe2OFU>
T98G MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TkPVExNTFyMDDuUS=> NEXJO4YzPC17NjDo NVXvSnQ1TE2VTx?= MV3pcohq[mm2czDj[YxtKGe{b4f0bEBqdiClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK= NFT3XG4zOzh6N{[0OS=>
DU145 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfEUXNQ M37BRmlEPTEkiMy2NEBvVQ>? NGXaSnkzOzh6NESyPC=>
LNCaP  MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y2RmROW09? M3r4RmlEPTEkiMy3OUBvVQ>? MWKyN|g5PDR{OB?=
PC3 MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K5b2ROW09? MXHJR|Ux6oj:MUe1JI5O NGWy[I8zOzh6NESyPC=>
RT4 NEfrS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ5LkKxJI5O M3O0UVI{Pzl{NkO5
5637 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe2bIYyUUN3ME20OU41PyCwTR?= NEj5V20zOzd7Mk[zPS=>
T24 M4m1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmniTWM2OD15OT6xNkBvVQ>? NWjtS3B{OjN5OUK2N|k>
MCF7  MV3GeY5kfGmxbjDBd5NigQ>? MYGxNFAhdk1? M2L2b|EhcA>? MoPMSG1UVw>? MorvdoVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>? Mlj0NlM4PzB{NES=
KB-V1  MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XLTGlEPTB;Mz65NkDPxE1? M2\yPVI{PTl|MUm2
Hec50co MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1faU2lEPTB;NTDuUS=> MkXVNlMyPDZ4OEe=
MDA-MB-468 NYXUcHAxSXCxcITvd4l{KEG|c3H5 MUmxM|UwOTBibl2= M3jVXFI1NzR6L{eyJIg> NGH4WZBFVVOR MmLzbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M4f6NVI{OTR2Mkm0
MCF10A NEPMfpFCeG:ydH;zbZMhSXO|YYm= MUWxM|UwOTBibl2= MmqzNlQwPDhxN{KgbC=> NFLTZWdFVVOR M1;WNolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M3m3cVI{OTR2Mkm0
Huh-7 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxM|ExNzFyMD:xNFAxKG6P MUS0PEBp Momw[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5 M3\BS|IzPzR3NUi3
Daoy  Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxMlg4PS1{NECgcm0> Mk\pO|IhcA>? MlfjSG1UVw>? NVjJdo1qUUN3ME21JI5O NGr0blAzOjN7MEK3PS=>
ONS-76 M1WxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf5UmV7OS56N{WtNlQxKG6P Ml;FO|IhcA>? NVvMVWpRTE2VTx?= MVnJR|UxRTdwNTDuUS=> MUCyNlM6ODJ5OR?=
SUM 149 NWfZT5F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSwMVExOCCwTR?= MUG3NkBp MVTpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= M4P4XVIzOzB7OUO5
MDA-MB-231 NYC0PYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\iNE0yODBibl2= Ml30O|IhcA>? MUPpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= M3y0UlIzOzB7OUO5
HR5 NVfZcJdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHUW5d3OC1zMECgcm0> NVvVWI5HPzJiaB?= Mm\ObY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MlTXNlI{ODl7M{m=
BT-474-M1 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrrOZZEOC1zMECgcm0> M2e3NFczKGh? M3;GOYlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> NXKzNFlyOjJ|MEm5N|k>
AU565 NFjDSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LY[|AuOTByIH7N NVTwVXBqPzJiaB?= M2LIUYlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MorSNlI{ODl7M{m=
T47D M4HtbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHlZpA3OC1zMECgcm0> NGq1PYs4OiCq NUThOoM1cW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MkTJNlI{ODl7M{m=
MCF7 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\ONE0yODBibl2= MVW3NkBp NIjGNm9qdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> MknPNlI{ODl7M{m=
HCT116p53(+/+) MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnMNVAuOTByMDDuUS=> MW[yOE81QCCq NVzyRZRUcW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGOxbYDs[ZRmdHliYYSgNlUhdk1? NELEZm4zOjJ4MkG3NS=>
HCT116p53(-/-) NF76ZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC5PGkyOC1zMECwJI5O NXq1foNVOjRxNEigbC=> NUT5VGlmcW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGOxbYDs[ZRmdHliYYSgNlUhdk1? MYGyNlI3OjF5MR?=
HeLa  NHrYW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH2dW4yOC1zMECgcm0> MVe0PEBp MXvEUXNQ NYrhSm9EUUN3ME21Nk46KG6P MoLpNlIxQDB{M{W=
HeLa  NHz2cI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;KNVAuOTByIH7N NITH[IE4OiCq M1\icGROW09? MluyTWM2OD13MD61JI5O M3vl[VIzODhyMkO1
GBC MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV23NkBp M3jVPGlEPTB;MUSuO|ghdk1? M1zTd|IyQTZ3N{O5
GB-CL-1 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXy3NkBp NFzwclZKSzVyPUWuNlIhdk1? NXHiUmVZOjF7NkW3N|k>
Mz-ChA-2 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXywWIZiPzJiaB?= M2K2ZmlEPTB;Mz6zNUBvVQ>? MojzNlE6PjV5M{m=
TGBC1-TKB NWW3eVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVOxOFQhcA>? NYrodopOUUN3ME22MlczKG6P NFjFZnczOTl4NUezPS=>
Wittier NWn4R5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfGZ4U2PzJiaB?= NG\LXFNKSzVyPUOuNlYhdk1? M{LZW|IyQTZ3N{O5
H-1 M3i1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHyPY84OiCq MnG3TWM2OD17LkW0JI5O NGfIRmMzOTl4NUezPS=>
HuH-28 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSxNIU4OiCq MnLZTWM2OD1zMT6xPUBvVQ>? MmPFNlE6PjV5M{m=
NEC NGXFPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLLN2tOPzJiaB?= MlHnTWM2OD17Lkm4JI5O MnXVNlE6PjV5M{m=
REB M1jFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rvbVczKGh? M4DMWWlEPTB;MUOuOVEhdk1? MVSyNVk3PTd|OR?=
CC-LP-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3mXnk4OiCq NIHnR4ZKSzVyPUWuPFQhdk1? M{fZU|IyQTZ3N{O5
CC-SW-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmntO|IhcA>? NV6yNJY3UUN3ME25MlU2KG6P M1n3ZVIyQTZ3N{O5
EGI-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXCTFhvPzJiaB?= NH\t[5dKSzVyPUGwMlczKG6P NFHG[mgzOTl4NUezPS=>
Sk-ChA-1 NWTFdGY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq5cGpCPzJiaB?= NXHmblJEUUN3ME2xO{4zKG6P MmLmNlE6PjV5M{m=
TFK-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD6WIQ4OiCq MVzJR|UxRTF|LkS1JI5O MV[yNVk3PTd|OR?=
786-O NUfJOnZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW4NVM2NThyIH7N M{TCdlk3KGh? MmHDTGNt MkHXd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P MoXFNlE3PDJ|N{S=
A498 NWrkXGp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH5TGxWPS16MDDuUS=> Mlm3PVYhcA>? M{XjfmhEdA>? Ml7sd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P M2HWdVIyPjR{M{e0
ACHN MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDTe4w2NThyIH7N NHzYdpQ6PiCq NWjHZXluUEOu NY\HTYZSe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NWnzcYM6OjF4NEKzO|Q>
Caki-1 M{fDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnwOXhVPS16MDDuUS=> NE\FeZI6PiCq NUnNcVljUEOu NYTicpd[e3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N MkXiNlE3PDJ|N{S=
SN12C NVWzNYtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXm1MVgxKG6P NEfGb2M6PiCq NHv1PGJJS2x? MkThd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P MWKyNVY1OjN5NB?=
HMC-1.1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUSxMVExODBibl2= MoPVO|IhcA>? NGHTeJVqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? M4Lx[FIyOjR{MUi5
HMC-1.2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTLfWoyNTFyMECgcm0> NUTYVWlXPzJiaB?= NF\KR2lqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? MkPDNlEzPDJzOEm=
C2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljVNU0yODByIH7N NWW0eFNtPzJiaB?= Mn3MbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m M{S2NlIyOjR{MUi5
CHP-212 M{X5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTDNU0yOjVibl2= M3XUSFI1NTF{MDDo MoLibY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NUW1ZYhrOjFzNkmyOFI>
IMR-32 MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0VFEuOTJ3IH7N MlnoNlQuOTJyIHi= MWPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NIjBS3EzOTF4OUK0Ni=>
Kelly NHnTTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[3NU0yOjVibl2= NITMT|IzPC1zMkCgbC=> NVnWc5dvcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NGfhUZkzOTF4OUK0Ni=>
SH-EP Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD1O2EyNTF{NTDuUS=> NXO1XZZ7OjRvMUKwJIg> MoDUbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= M4LDW|IyOTZ7MkSy
SH-SY5Y NIfHfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxMVEzPSCwTR?= NIrOUGwzPC1zMkCgbC=> MkjybY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MlfaNlEyPjl{NEK=
SK-N-AS MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPScJEyNTF{NTDuUS=> Mn3RNlQuOTJyIHi= NEew[W9qdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NWnM[nQ3OjFzNkmyOFI>
SK-N-BE NXqyRlVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3LNU0yOjVibl2= NH;nT2IzPC1zMkCgbC=> NFLscGpqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MYCyNVE3QTJ2Mh?=
KG1 NWfKWlNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPROJMyNzFyL{GwNEBvVQ>? NH20[Gc4OiCq MWXEUXNQ MXrpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M2D5cFE6PDV6M{W4
U937 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrGXHp3OS9zMD:xNFAhdk1? MluxO|IhcA>? M4rQfmROW09? M4TBRYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MXSxPVQ2QDN3OB?=
CAL62 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTDNE4yNTFyMDDuUS=> M3TCWlczKGh? NFLuV|NFVVOR M1jad2VEPTB;MT60JI5O NHHaNFkyQTJ{M{W1Ny=>
OCUT-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWWwMlEuOTByIH7N NYLvUJZYPzJiaB?= MWnEUXNQ MnXFSWM2OD1{LkOgcm0> NYDze4J5OTl{MkO1OVM>
8505C NXrSVoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TTOFAvOS1zMECgcm0> M2T6VlczKGh? NULaSnNiTE2VTx?= MX7FR|UxRTNwMjDuUS=> M2nadVE6OjJ|NUWz
ACT-1 NHrBb2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[3SnRLOC5zLUGwNEBvVQ>? NVGxdmtrPzJiaB?= MkTaSG1UVw>? NYfvNJdGTUN3ME21MlQhdk1? MmL5NVkzOjN3NUO=
SW1736 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\XTJoxNjFvMUCwJI5O MkTKO|IhcA>? NVfMWXhRTE2VTx?= MlXGSWM2OD13Lk[gcm0> NFrEfHAyQTJ{M{W1Ny=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

Related PLK Products4

Tags: buy BI 2536 | BI 2536 supplier | purchase BI 2536 | BI 2536 cost | BI 2536 manufacturer | order BI 2536 | BI 2536 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID