BI 2536

For research use only.

Catalog No.S1109

162 publications

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

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Selleck's BI 2536 has been cited by 162 publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rR[2lEPTB;MD6wNFc4PiEQvF2= MkXEV2FPT0WU
ACN M4PDemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDKN4VKSzVyPUCuNFA5PDNizszN MWHTRW5ITVJ?
TE-8 NIq0RoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj1TWM2OD1yLkCwPVQyKM7:TR?= M3PlSXNCVkeHUh?=
LC-2-ad M3nkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jjRWlEPTB;MD6wNVA6OyEQvF2= MnftV2FPT0WU
ALL-PO M3r4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX3c4l6UUN3ME2wMlAyOyEQvF2= NYHZZZg{W0GQR1XS
EW-16 NWjGN45yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEGzN|Yh|ryP MXTTRW5ITVJ?
KM12 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zwcmlEPTB;MD6wNVM1QCEQvF2= MVLTRW5ITVJ?
GI-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrpTWM2OD1yLkCxN|g{KM7:TR?= MUjTRW5ITVJ?
LS-411N NGPJSWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELBOYdKSzVyPUCuNFE1ODdizszN MWfTRW5ITVJ?
ES8 NX\ZZXdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrDT4d2UUN3ME2wMlAyPDl2IN88US=> MUHTRW5ITVJ?
SNU-C2B MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEG1NlYh|ryP NHjaSWFUSU6JRWK=
CESS M1HrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S4OGlEPTB;MD6wNVYxOiEQvF2= MlL3V2FPT0WU
697 NE\YOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\PcGlEPTB;MD6wNVY3QCEQvF2= MU\TRW5ITVJ?
NCI-H1963 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\jepdGUUN3ME2wMlAyPjd|IN88US=> MULTRW5ITVJ?
IA-LM NHrWWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jYZmlEPTB;MD6wNVY5QCEQvF2= MnfpV2FPT0WU
SW954 NEPpZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK3V5ZKSzVyPUCuNFE4ODVizszN NX2wWFhbW0GQR1XS
RL95-2 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rCSWlEPTB;MD6wNVc{QCEQvF2= NFnRNpFUSU6JRWK=
LXF-289 NXHCZZh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm0SYRKSzVyPUCuNFE4PyEQvF2= NVXaXpRWW0GQR1XS
OCUB-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PrOWlEPTB;MD6wNVgzPiEQvF2= NHvreoFUSU6JRWK=
RKO M3ryTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLvTWM2OD1yLkCxPVg4KM7:TR?= NHPEOZNUSU6JRWK=
LOUCY NUjOTHpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fw[GlEPTB;MD6wNlA2KM7:TR?= NFriVnpUSU6JRWK=
NOS-1 M2n5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEKwPVMh|ryP Mn7KV2FPT0WU
A4-Fuk NWPQWHdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3PTWM2OD1yLkCyNlE5KM7:TR?= NH\6VolUSU6JRWK=
A388 Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnubYZKSzVyPUCuNFIzOjdizszN NHzRNHhUSU6JRWK=
TE-9 NIizfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrpN3l{UUN3ME2wMlAzOjZzIN88US=> MmXxV2FPT0WU
KURAMOCHI MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD2UI9SUUN3ME2wMlAzOjh3IN88US=> M4TFZXNCVkeHUh?=
KALS-1 M{f5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzjTWM2OD1yLkCyN|M5KM7:TR?= Mk\nV2FPT0WU
HOP-62 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHGTWM2OD1yLkCyOFIh|ryP NWPpSXh4W0GQR1XS
RPMI-8402 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLlO3lKSzVyPUCuNFI2ODhizszN MlXMV2FPT0WU
TE-1 NWn6e2V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M12yd2lEPTB;MD6wNlUyOiEQvF2= NVnMUI1rW0GQR1XS
CCRF-CEM NIjqO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEK1OFMh|ryP MmfpV2FPT0WU
HUTU-80 NFLHdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izU2lEPTB;MD6wNlYzPCEQvF2= MYfTRW5ITVJ?
NCI-H1648 NH:2XWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ITWM2OD1yLkCyOlQ4KM7:TR?= MVfTRW5ITVJ?
HCE-4 M{nZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SweGlEPTB;MD6wNlY5OiEQvF2= MUXTRW5ITVJ?
ETK-1 NH3aUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln2TWM2OD1yLkCyO|M3KM7:TR?= M1zBTnNCVkeHUh?=
TE-15 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPWTWM2OD1yLkCyO|M5KM7:TR?= MmTFV2FPT0WU
BE-13 Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPx[WVKSzVyPUCuNFI4PCEQvF2= MnnsV2FPT0WU
KE-37 M4T5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P6NGlEPTB;MD6wNlc1OSEQvF2= MXTTRW5ITVJ?
NCI-H1355 NGW1V3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SxfWlEPTB;MD6wNlc5OyEQvF2= M2TLUnNCVkeHUh?=
TE-11 NVnrR5dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCxPYFxUUN3ME2wMlAzQDB7IN88US=> M{DBW3NCVkeHUh?=
BL-70 M4nWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\qXXhEUUN3ME2wMlAzQDV5IN88US=> MYfTRW5ITVJ?
ES6 NXvjXplwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEK4PFEh|ryP MlT0V2FPT0WU
GT3TKB NIHNeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGeyd5lKSzVyPUCuNFI6PTNizszN MYTTRW5ITVJ?
LB647-SCLC NIfHflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEOxPVUh|ryP M{P2SXNCVkeHUh?=
NB13 NV7CXW1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;VR2lEPTB;MD6wN|MyPiEQvF2= NInZeoFUSU6JRWK=
ST486 NYXZUml2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjnTWM2OD1yLkCzN|M4KM7:TR?= NUPYTnpMW0GQR1XS
NCI-H82 M2X6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEOzOFMh|ryP M{HXNXNCVkeHUh?=
NTERA-S-cl-D1 NFTUdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILPTo9KSzVyPUCuNFM{QTlizszN M4PTTXNCVkeHUh?=
ES4 NXTSco1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPaOndKSzVyPUCuNFM1PjNizszN NUfwTnpjW0GQR1XS
SK-NEP-1 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j5UmlEPTB;MD6wN|Q6QSEQvF2= MUjTRW5ITVJ?
Becker NYDsXlBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEO1OVUh|ryP MnjaV2FPT0WU
A101D NELZU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jPN2lEPTB;MD6wN|c1QCEQvF2= M{fuTnNCVkeHUh?=
SK-UT-1 M2LvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn32TWM2OD1yLkCzO|c1KM7:TR?= Ml\tV2FPT0WU
SW982 NXjpdY9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vLVmlEPTB;MD6wN|c6KM7:TR?= NWXSb|dQW0GQR1XS
TE-10 M4rVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7wTWM2OD1yLkC0NFQ3KM7:TR?= NH7w[GtUSU6JRWK=
OVCAR-4 MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXabpVKSzVyPUCuNFQxPTlizszN MV;TRW5ITVJ?
KP-N-YS NWe4bHV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P0RmlEPTB;MD6wOFA5PSEQvF2= NUPTXpdQW0GQR1XS
BL-41 NXnvWFhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fqT2lEPTB;MD6wOFEzPSEQvF2= NVjrSJp2W0GQR1XS
MZ1-PC NEH1R|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIGxcWhKSzVyPUCuNFQyOjdizszN M4XUXHNCVkeHUh?=
PF-382 NHX0SYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HQWmlEPTB;MD6wOFE6QCEQvF2= M3fqW3NCVkeHUh?=
MOLT-13 NHTOPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMESyN|gh|ryP MVTTRW5ITVJ?
HCC1599 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\uTWM2OD1yLkC0NlU5KM7:TR?= NHX1V|VUSU6JRWK=
IST-MEL1 MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;XSolDUUN3ME2wMlA1PDR{IN88US=> NVTBdHNNW0GQR1XS
LU-139 NYTkfWZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH1TWM2OD1yLkC0OFQzKM7:TR?= NVuwUlBoW0GQR1XS
MS-1 M2rMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWwemh4UUN3ME2wMlA1PzBzIN88US=> MkC4V2FPT0WU
MFH-ino NITrcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DjPGlEPTB;MD6wOVAxOyEQvF2= M13TVHNCVkeHUh?=
IMR-5 NVrkOGxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEWwNlEh|ryP NYjqXo5MW0GQR1XS
TE-5 NHrTXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn3VnBKSzVyPUCuNFUxPjNizszN MnXWV2FPT0WU
DJM-1 NISwWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSxT3hTUUN3ME2wMlA2OTR{IN88US=> NYPWUpF4W0GQR1XS
NB17 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfXdnJKSzVyPUCuNFUzODdizszN NYX2bHY6W0GQR1XS
KARPAS-45 NHyxXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHqVnFMUUN3ME2wMlA2OzV6IN88US=> NEjoe5VUSU6JRWK=
TGBC1TKB Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXaTWM2OD1yLkC1OFA2KM7:TR?= NV3W[JA4W0GQR1XS
ML-2 NHu3emlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDWZ2t7UUN3ME2wMlA2PDF2IN88US=> MU\TRW5ITVJ?
no-10 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjZZ5RKSzVyPUCuNFU1PzRizszN MU\TRW5ITVJ?
CTV-1 M2jnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWydHI3UUN3ME2wMlA2PTB{IN88US=> Ml;xV2FPT0WU
SJSA-1 NGOzblVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;COGlEPTB;MD6wOVUzKM7:TR?= NV\LOZBtW0GQR1XS
HC-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHsW4tKSzVyPUCuNFU2QTdizszN NEHxZpFUSU6JRWK=
TE-12 NUnxZ45JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T4dGlEPTB;MD6wOVYyOyEQvF2= M3fyUXNCVkeHUh?=
KY821 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XBN2lEPTB;MD6wOVY{OiEQvF2= M{fXR3NCVkeHUh?=
TALL-1 NHr0bnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS4S|l3UUN3ME2wMlA2PzB6IN88US=> MUnTRW5ITVJ?
DEL NXfHT4RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrXTWM2OD1yLkC1O|A6KM7:TR?= NV3WSFI4W0GQR1XS
TE-6 NYDGfmRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT5TWM2OD1yLkC1O|IzKM7:TR?= MWfTRW5ITVJ?
SK-LMS-1 NHO4PW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEW4NFUh|ryP MXzTRW5ITVJ?
EW-1 M{PJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn65TWM2OD1yLkC1PFM4KM7:TR?= MonmV2FPT0WU
8-MG-BA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HvfmlEPTB;MD6wOVg2OSEQvF2= NUH2SlVMW0GQR1XS
NALM-6 M1;JOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLuTWM2OD1yLkC1PVc{KM7:TR?= NV\uXpc2W0GQR1XS
LB771-HNC NFXSVVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zpeWlEPTB;MD6wOVk4QSEQvF2= NECwVIdUSU6JRWK=
HT-144 MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[xN{DPxE1? NHvIXYRUSU6JRWK=
KM-H2 NX\ubJFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITFdoRKSzVyPUCuNFYzOjFizszN NYHab|JHW0GQR1XS
SF268 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwME[yPFYh|ryP NF3Sb5ZUSU6JRWK=
RS4-11 NFrCeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzIW2lKSzVyPUCuNFY{ODRizszN M3;mNnNCVkeHUh?=
MHH-PREB-1 NWPWelJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXqTWM2OD1yLkC2N|E6KM7:TR?= MVTTRW5ITVJ?
ATN-1 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfITWM2OD1yLkC2N|Q2KM7:TR?= MnuyV2FPT0WU
BB30-HNC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwME[0N|Yh|ryP NXi1R5JGW0GQR1XS
CPC-N M2LJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPJfIRKSzVyPUCuNFY2OjRizszN NXvzelc6W0GQR1XS
NB1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrUTWM2OD1yLkC2OlE{KM7:TR?= M4XwS3NCVkeHUh?=
KS-1 M2j0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nGT2lEPTB;MD6wOlc1QCEQvF2= NGrTSGdUSU6JRWK=
RXF393 M{PXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnTTWM2OD1yLkC2O|Y1KM7:TR?= M{HldnNCVkeHUh?=
IST-SL2 MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEewNFQh|ryP MlT2V2FPT0WU
GI-ME-N NFyxboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEeyPFYh|ryP NVvq[5RiW0GQR1XS
VA-ES-BJ M{DKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEe0O|Uh|ryP MnjyV2FPT0WU
NCI-H1581 NV3OVYNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEe0O|gh|ryP M17BWXNCVkeHUh?=
U-266 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLNd4hQUUN3ME2wMlA4PDl5IN88US=> NGOyW3dUSU6JRWK=
DMS-114 M4\GOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES4NJVKSzVyPUCuNFc2OjhizszN Mk\DV2FPT0WU
NCI-H187 NF3oXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEe3NlYh|ryP NVnaWlZPW0GQR1XS
SW962 NIq3cVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzHTWM2OD1yLkC3PFM6KM7:TR?= NYDWTIF{W0GQR1XS
MONO-MAC-6 M1fQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HyOWlEPTB;MD6wO|k5PiEQvF2= MnnwV2FPT0WU
MOLT-16 MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzuXZpKSzVyPUCuNFgyOjFizszN NHq0fGtUSU6JRWK=
KNS-42 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCyXXg{UUN3ME2wMlA5OTZzIN88US=> NWH5T2RrW0GQR1XS
CMK NHz0PZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojQTWM2OD1yLkC4NlI2KM7:TR?= NFSxbXlUSU6JRWK=
Ramos-2G6-4C10 M4nBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXkWYdLUUN3ME2wMlA5OjJ3IN88US=> M{fmSnNCVkeHUh?=
Daudi MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEiyOVYh|ryP NV;KZ4VwW0GQR1XS
NCI-H510A MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT4TWM2OD1yLkC4N|M3KM7:TR?= MmnoV2FPT0WU
LB831-BLC NIXkZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;5fJdKSzVyPUCuNFg2PjFizszN M2LXU3NCVkeHUh?=
HEL M{fYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULHXo04UUN3ME2wMlA5PjZ6IN88US=> MWTTRW5ITVJ?
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A253 M2PHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqzS4tLUUN3ME2wMlA5QDJ{IN88US=> M2jZbHNCVkeHUh?=
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COR-L279 NHv6eJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjSWXZbUUN3ME2wMlA6PTV4IN88US=> NEDDXopUSU6JRWK=
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DU-4475 NYLrXGFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojMTWM2OD1yLkGwOFA4KM7:TR?= MVPTRW5ITVJ?
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HD-MY-Z Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTFTWM2OD1yLkGwPFU3KM7:TR?= MWnTRW5ITVJ?
K-562 NF\0SohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjCVoxKSzVyPUCuNVA5PThizszN MWXTRW5ITVJ?
JAR MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32yb2lEPTB;MD6xNFkzPSEQvF2= MYjTRW5ITVJ?
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NCI-H524 NETYTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsOVlKSzVyPUCuNVEzPzRizszN MXPTRW5ITVJ?
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HT Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT3OYFGUUN3ME2wMlE{PTd2IN88US=> MUfTRW5ITVJ?
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NCI-H747 NYDifokxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfDZ2dKSzVyPUCuNVM4KM7:TR?= MXjTRW5ITVJ?
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GB-1 NYjWXIFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTVTWM2OD1yLkG0OVI3KM7:TR?= NXrtR3RqW0GQR1XS
COR-L88 M3Hk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrzTWM2OD1yLkG0PFAzKM7:TR?= NXP4fYtsW0GQR1XS
NKM-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH3Z2w2UUN3ME2wMlE1QTB4IN88US=> MWDTRW5ITVJ?
NB5 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMUW0OlIh|ryP NYnsdFU1W0GQR1XS
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SCLC-21H NEnqcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW4RXU1UUN3ME2wMlE2PzB{IN88US=> Mn3SV2FPT0WU
COLO-684 NYjQ[ZJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMUW3NlEh|ryP MofuV2FPT0WU
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NCI-H64 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jCPGlEPTB;MD6xOlM1PyEQvF2= MlToV2FPT0WU
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LOXIMVI MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjxZY5iUUN3ME2wMlE3QTR7IN88US=> M4\VZnNCVkeHUh?=
ARH-77 NVnWNFVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTDTWM2OD1yLkG3N|c6KM7:TR?= MoLUV2FPT0WU
DOHH-2 NYTlfGg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLBTIpNUUN3ME2wMlE4Pjd{IN88US=> NEDYWmVUSU6JRWK=
COLO-320-HSR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnnNWZbUUN3ME2wMlE5OTV2IN88US=> NHnhdGJUSU6JRWK=
NB6 NVnJWWxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfWfplDUUN3ME2wMlE5PTZ4IN88US=> NHvwb4dUSU6JRWK=
L-428 NIixRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMUi4NVMh|ryP NVTlfoZmW0GQR1XS
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NCI-H2141 Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX1TWM2OD1yLkG5NFEyKM7:TR?= NXLYVGNNW0GQR1XS
KARPAS-299 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Lx[2lEPTB;MD6xPVI1OSEQvF2= M4PP[nNCVkeHUh?=
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UACC-257 NWT1O3lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;qbGpKSzVyPUCuNVk6PDdizszN Mn\wV2FPT0WU
EVSA-T NWCzWlcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j5TWlEPTB;MD6yNFMyOiEQvF2= NHHVeZBUSU6JRWK=
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GAK MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETWZZlKSzVyPUCuNlEyQDlizszN MWHTRW5ITVJ?
HH MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXHdYxnUUN3ME2wMlIyPDB3IN88US=> NX[yVFVtW0GQR1XS
NCI-H1436 Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfPPJNKSzVyPUCuNlE1PjRizszN Mn7WV2FPT0WU
GR-ST MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW5PVVDUUN3ME2wMlIyPDh6IN88US=> Ml7FV2FPT0WU
BC-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMkK2NVYh|ryP NHLzOYJUSU6JRWK=
SIG-M5 NIPaempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKz[5ZKSzVyPUCuNlI4OjdizszN NID1cFFUSU6JRWK=
NCI-H345 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[4V3dKSzVyPUCuNlM5ODVizszN NIPYTWdUSU6JRWK=
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LB1047-RCC MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzTTo9KSzVyPUCuNlQ1OSEQvF2= NXrZOZNuW0GQR1XS
CTB-1 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PEOGlEPTB;MD6yOFQ6OyEQvF2= NHzLSVRUSU6JRWK=
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MEG-01 NITNWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMkW2O|Mh|ryP NI\tRlZUSU6JRWK=
NCI-H209 NEjDSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e0dGlEPTB;MD6yOlM4PCEQvF2= M2\5[3NCVkeHUh?=
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QIMR-WIL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v5XGlEPTB;MD6yO|E2PSEQvF2= NILwR3pUSU6JRWK=
NMC-G1 NF;TcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7ZfVZCUUN3ME2wMlI5OjF5IN88US=> MWrTRW5ITVJ?
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SW684 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwM{CwOFch|ryP M{\pSXNCVkeHUh?=
MV-4-11 NUjXcVdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H5c2lEPTB;MD6zNFc5QCEQvF2= MlHpV2FPT0WU
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RH-1 M4XlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HkTmlEPTB;MD6zNVg4OSEQvF2= M1LOOnNCVkeHUh?=
CP66-MEL M3\xeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwM{G4O|gh|ryP MVXTRW5ITVJ?
EC-GI-10 NETqZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ppc2lEPTB;MD6zNlk5PyEQvF2= MVrTRW5ITVJ?
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KMOE-2 NFvFfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnZXW01UUN3ME2wMlM2OTd3IN88US=> NFPxSZdUSU6JRWK=
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HDLM-2 NWfyZWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwM{e4NVQh|ryP Mn\pV2FPT0WU
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NOMO-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\kT3l{UUN3ME2wMlQ{QDZizszN Mn3YV2FPT0WU
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COLO-668 NHTSdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrMTWM2OD1yLkS1OlY5KM7:TR?= MnvDV2FPT0WU
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TE-441-T NHvycXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3FWphmUUN3ME2wMlUxOTJizszN M4PMSXNCVkeHUh?=
MDA-MB-134-VI MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq1TWM2OD1yLkWwPVIyKM7:TR?= MlHWV2FPT0WU
SCC-3 NXHVbmI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nZRWlEPTB;MD61NVg4OyEQvF2= M{\ZbnNCVkeHUh?=
KLE MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojzTWM2OD1yLkWyNVcyKM7:TR?= Ml;YV2FPT0WU
LB2241-RCC Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULnSpNYUUN3ME2wMlUzPTJ3IN88US=> NEjIfZhUSU6JRWK=
NCI-H1417 NH;0OoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;1TWM2OD1yLkWzOFM2KM7:TR?= NEOyO|NUSU6JRWK=
NCI-H2081 M33pdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL0b3E5UUN3ME2wMlU5PjFzIN88US=> MX\TRW5ITVJ?
NCI-H1522 M{PXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrLd4x[UUN3ME2wMlU6Ozh|IN88US=> Mm\hV2FPT0WU
NCI-H889 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJPWlEPTB;MD61PVg1PCEQvF2= M2P4VHNCVkeHUh?=
CGTH-W-1 NEXrfJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDUbVdqUUN3ME2wMlYxPzV3IN88US=> MXHTRW5ITVJ?
EB-3 NHn3UVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNkGxOVMh|ryP MlrCV2FPT0WU
D-336MG NX\4OoIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr1TWM2OD1yLk[xO|kyKM7:TR?= NI\ySY9USU6JRWK=
LC-1F MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvQTVVLUUN3ME2wMlYzPTl{IN88US=> NWq3NI15W0GQR1XS
MHH-NB-11 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHYTWM2OD1yLk[zPFAyKM7:TR?= NFjpRoFUSU6JRWK=
SK-N-FI M2ftSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX0bYVKSzVyPUCuOlM6OSEQvF2= MYrTRW5ITVJ?
NCI-H69 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwNkS4O|kh|ryP M3rMVHNCVkeHUh?=
SCH M3nIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwNk[wNlMh|ryP NHWxWFdUSU6JRWK=
LS-513 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml72TWM2OD1yLk[3NlU6KM7:TR?= MkLKV2FPT0WU
CP67-MEL MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW4XVNtUUN3ME2wMlY4PTl4IN88US=> M3L5RXNCVkeHUh?=
GCIY MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5TWM2OD1yLkewN|Y{KM7:TR?= NEDOSWFUSU6JRWK=
SHP-77 M3;q[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzFSlhLUUN3ME2wMlcxPzN2IN88US=> NWfQT3ZRW0GQR1XS
EHEB NWPObpVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfIV5VKUUN3ME2wMlcyQDV2IN88US=> M4rGbHNCVkeHUh?=
D-247MG NILhc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTHV4lSUUN3ME2wMlc{OjN{IN88US=> M1XST3NCVkeHUh?=
Raji NXfTNZoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTLTWM2OD1yLke0PVg6KM7:TR?= Ml\ZV2FPT0WU
MPP-89 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\aRW1KSzVyPUCuO|U6PzhizszN NXziTHF5W0GQR1XS
EKVX NWjSWZVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwN{mwO|Mh|ryP MXTTRW5ITVJ?
HCC2218 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwN{mxN|Eh|ryP Mn;CV2FPT0WU
KNS-81-FD NHzHSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nhc2lEPTB;MD64NVAyOSEQvF2= MWrTRW5ITVJ?
HCC2157 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwOES5OVEh|ryP MWnTRW5ITVJ?
BT-474 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW0boUyUUN3ME2wMlg5QDV2IN88US=> M1TYTXNCVkeHUh?=
NCI-H748 NFf0U|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml20TWM2OD1yLkmxNkDPxE1? MlKyV2FPT0WU
EW-24 NFWycnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnoeYJqUUN3ME2wMlkzODB{IN88US=> MULTRW5ITVJ?
D-263MG MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi2W4hKSzVyPUCuPVQ2OTJizszN Mmi4V2FPT0WU
OMC-1 NFLEfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEizSnVKSzVyPUCuPVY{PzNizszN M13GSHNCVkeHUh?=
NCI-H2196 NGq2TGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ES2lEPTB;MD65O|c4PyEQvF2= NUO0bIpJW0GQR1XS
HAL-01 MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jxN2lEPTB;MD65PVg4OiEQvF2= NITZW2xUSU6JRWK=
NCI-H2107 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SzUmlEPTB;MT6wNVg2PCEQvF2= M4nIV3NCVkeHUh?=
LB996-RCC NWXtSJlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvTPYZKSzVyPUGuNFgxPTFizszN NVLCb|MyW0GQR1XS
NCI-H1395 NGH3TIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TVd2lEPTB;MT6xNFY4KM7:TR?= MV\TRW5ITVJ?
CHP-126 MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHhNXVKSzVyPUGuNVYyQTlizszN MkfCV2FPT0WU
NB69 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH0TWM2OD1zLkK2NVQ5KM7:TR?= M4m1V3NCVkeHUh?=
CAS-1 NVjxcJFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwM{SyN|Eh|ryP MmnVV2FPT0WU
JVM-3 M1TiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHsTWM2OD1zLkS3PFU2KM7:TR?= NXHiR25bW0GQR1XS
DMS-153 M1LVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3MTWM2OD1zLkW3Olc1KM7:TR?= NHTPb5RUSU6JRWK=
SK-MEL-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrYUFhHUUN3ME2xMlcyPzh7IN88US=> MVvTRW5ITVJ?
NCI-H1155 NHTrWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rEU2lEPTB;MT63N|Y4PiEQvF2= M4ezfXNCVkeHUh?=
NCI-H1092 M2jxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\De2lEPTB;MT63OlE5OiEQvF2= NUCwOnU2W0GQR1XS
LU-165 NYXqPXZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Hyc2lEPTB;MT64OlQ4PiEQvF2= NGnBSINUSU6JRWK=
HL-60 M4XwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHoTHdIUUN3ME2xMlk6QTB6IN88US=> MUDTRW5ITVJ?
REH MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwMEC1PFIh|ryP NULnOVhGW0GQR1XS
JVM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwME[xN|Uh|ryP MW\TRW5ITVJ?
MN-60 M{C4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zpO2lEPTB;Mj6xO|MxQCEQvF2= M4foe3NCVkeHUh?=
SCC-15 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L0NmlEPTB;Mj6yNFI4KM7:TR?= M4rz[3NCVkeHUh?=
SNU-C1 NWjkZ4R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJwMkGzOFMh|ryP NXPQZ3hGW0GQR1XS
SK-MEL-1 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1R3RpUUN3ME2yMlMzODR5IN88US=> M3P4T3NCVkeHUh?=
TGW MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTEVZJKSzVyPUKuN|UxOjdizszN MlzEV2FPT0WU
CA46 MlrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLjPYxKSzVyPUKuO|U6PjdizszN NWLQeFVjW0GQR1XS
NCI-H23 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ftOGlEPTB;Mj64NFc6OSEQvF2= M1TmNnNCVkeHUh?=
MMAC-SF MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\UcHpKSzVyPUKuPFY3OjhizszN NWDj[W4{W0GQR1XS
NCI-H2171 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LpVmlEPTB;Mz6wN|Q1QCEQvF2= NFXsbYVUSU6JRWK=
A704 MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\F[GlEPTB;Mz6xOFE6PCEQvF2= NInsSpNUSU6JRWK=
DB M2S4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwMkW1O|Yh|ryP MVzTRW5ITVJ?
NCI-H719 NWXWZ|BUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjLeYlKSzVyPUOuN|A{QDRizszN MV;TRW5ITVJ?
MC-CAR M1\zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjDZmtKSzVyPUOuOVQ5OTdizszN NInseoNUSU6JRWK=
SIMA M37XeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNwNUi0NVYh|ryP MkK3V2FPT0WU
SW872 NVjzc2Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDxVGpKSzVyPUOuO|gyODFizszN NWfaUFRmW0GQR1XS
HCC1187 M{DQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\COFNKSzVyPUOuO|g{OTVizszN NVLDbXpDW0GQR1XS
EW-13 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTNwOEO0NVch|ryP NH2wbG1USU6JRWK=
NCI-SNU-1 NHmxR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljmTWM2OD12LkKxPVk6KM7:TR?= NEjKW2pUSU6JRWK=
NCI-H226 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu1NpZmUUN3ME20MlM{PjB4IN88US=> M{\FOXNCVkeHUh?=
RPMI-8866 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;GdnhKSzVyPUSuN|YxOjlizszN NUXwdlVRW0GQR1XS
OCI-AML2 M4OxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS1S5dKSzVyPUSuOVUzOyEQvF2= Mon1V2FPT0WU
LU-65 NW\5[W5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRwOUOwN|Mh|ryP Mmm2V2FPT0WU
SK-N-DZ MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLVc2pKSzVyPUWuOlM1PjVizszN NIDidIpUSU6JRWK=
NB14 MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzienpKSzVyPUWuPVcyOzVizszN MWnTRW5ITVJ?
COLO-829 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjGNVFKSzVyPU[uN|M{PTlizszN Ml3lV2FPT0WU
MHH-CALL-2 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWyVYtXUUN3ME22MlUyPTB6IN88US=> MYHTRW5ITVJ?
NCI-H1770 NIfyclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHw[2JKSzVyPU[uOlY6ODRizszN NVe5cYVEW0GQR1XS
ECC4 M3\vXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTZwOEKxO|kh|ryP MXnTRW5ITVJ?
A498 Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfOTWM2OD14Lki3NVkzKM7:TR?= NWXI[3FjW0GQR1XS
DMS-79 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHUSHFbUUN3ME23MlA1PTF{IN88US=> NHvCZolUSU6JRWK=
P30-OHK MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX2bGVWUUN3ME23MlIyQTB4IN88US=> M3i4UXNCVkeHUh?=
D-502MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXVVnkyUUN3ME23Mlk5OzZizszN NEn6RYRUSU6JRWK=
RCC10RGB NIHrfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHBU2gxUUN3ME24MlA3OjhizszN M2O5RXNCVkeHUh?=
U-698-M MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTMTWM2OD16LkK5NlI3KM7:TR?= NFnzUIFUSU6JRWK=
BB49-HNC NF\zVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTFTWM2OD17LkSyNlY2KM7:TR?= NHP0RYlUSU6JRWK=
ES1 NX;Ec2lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nGe2lEPTB;OT62PFk2PiEQvF2= M{T1T3NCVkeHUh?=
MFM-223 NVXPb|lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXNfYtKUUN3ME2xNE46QTJ5IN88US=> NF;FO4RUSU6JRWK=
C2BBe1 NX;ITmJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLaZ3F6UUN3ME2xNU4{PTJ|IN88US=> MlvZV2FPT0WU
EB2 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\WTWM2OD1zMj62PFgyKM7:TR?= M3nIZnNCVkeHUh?=
C8166 NEnaPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF|LkizNFMh|ryP NEPmPZpUSU6JRWK=
ES3 M160WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnXNGxuUUN3ME2xN{46QTd5IN88US=> NVSxR5JYW0GQR1XS
NCI-H1650 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy2cZh[UUN3ME2xOk4{PzZ3IN88US=> M{X5PXNCVkeHUh?=
Mo-T MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLHTWM2OD1zNz60NFI6KM7:TR?= NFvVeGNUSU6JRWK=
NB7 NGO0XnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF5Lke0Olch|ryP MXTTRW5ITVJ?
ES7 M1;3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PM[mlEPTB;MUmuOVUxPyEQvF2= NUPKUFl[W0GQR1XS
ES5 NY\BNnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvYOpRMUUN3ME2yNU44PjdzIN88US=> NH;jSVFUSU6JRWK=
MSTO-211H MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fsNmlEPTB;MkGuPFg2QCEQvF2= NISwSVNUSU6JRWK=
U-87-MG NXHJNpZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYraWJJQUUN3ME2yOU4yQTZ4IN88US=> MYjTRW5ITVJ?
THP-1 NHrsZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HCSmlEPTB;MkmuO|IxOSEQvF2= MoDLV2FPT0WU
NB10 NIjKdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNyLkK2PVQh|ryP MoXoV2FPT0WU
NH-12 NXHnSIdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P3T2lEPTB;M{OuNlAyPyEQvF2= MlLFV2FPT0WU
COLO-824 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfUO4JKSzVyPUO0MlExODZizszN MnTWV2FPT0WU
SKM-1 NInSfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF32bXFKSzVyPUO3Mlg1OjJizszN NV7wNpk2W0GQR1XS
NCI-H1838 M4H0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQTWM2OD1|OD6zO|k4KM7:TR?= NUPpR|NCW0GQR1XS
RL M2LSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHZTWM2OD1|OT6yOFc4KM7:TR?= MnfBV2FPT0WU
COLO-800 M1vkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2myO2lEPTB;NECuNFc4OyEQvF2= Ml7pV2FPT0WU
KG-1 NFu1cllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS4bnJQUUN3ME20NE45QTV3IN88US=> NFv6O5VUSU6JRWK=
TUR M2P5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLmTWM2OD12MT62N|k6KM7:TR?= MmTmV2FPT0WU
LNCaP-Clone-FGC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\zb41KSzVyPUSxMlkxOTdizszN NYX0[W5tW0GQR1XS
NCI-H322M M3Kxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\VTWM2OD12Mj61PVg1KM7:TR?= MknYV2FPT0WU
LNCaP  MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fmc2lEPTB;OUGuN{BvVQ>? NXXBSVBwOjV3MEWxO|Q>
C4-2 M4rFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrqfndKSzVyPUigcm0> MoTYNlU2ODVzN{S=
JURKAT MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LOTVI1KGh? MWjJR|UxRTRzNj62OkBvVQ>? MYqyOFUyQTl7NR?=
MOLT-4 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmyOEBp M3jXWWlEPTB;Mki1N{42KG6P NWnrSY86OjR3MUm5PVU>
REH NFiwfXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:yOEBp Mn;GTWM2OD1{OEeuOlghdk1? MofqNlQ2OTl7OUW=
NALM-6 M1j6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvJ[oF2OjRiaB?= NGLlNmFKSzVyPUO0N|MxKG6P MXuyOFUyQTl7NR?=
RS 4;11 M1PTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\MS2wzPCCq M2PnNmlEPTB;NUG5MlA2KG6P NIP2S|AzPDVzOUm5OS=>
697 NIrxcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Hk[FI1KGh? MkCzTWM2OD1{MUC3MlEhdk1? M4KwRlI1PTF7OUm1
SIL-ALL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmyOEBp MWfJR|UxRTF7OT63O{BvVQ>? NG[5RoYzPDVzOUm5OS=>
CEM MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrjNlQhcA>? MXPJR|UxRTV{LkG4JI5O MXuyOFUyQTl7NR?=
P12 M4TPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\WNGYzPCCq NYm3WlZKUUN3ME2zPU4zPyCwTR?= NXHYSYIyOjR3MUm5PVU>
NALM-16 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPWXpgzPCCq M2m0S2lEPTB;OU[uNlghdk1? MUiyOFUyQTl7NR?=
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SN12C M1LvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXUWpFMPS16MDDuUS=> M2f6c|k3KGh? NX:2[G1TUEOu M2f6UpN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MY[yNVY1OjN5NB?=
HMC-1.1 Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\BNU0yODByIH7N M1;2TFczKGh? NWTsbpk2cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NX3r[lhGOjF{NEKxPFk>
HMC-1.2 NYmzRopZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDkNU0yODByIH7N MVO3NkBp NWXwdmRScW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n M2qwfVIyOjR{MUi5
C2 MoXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HMclEuOTByMDDuUS=> MXG3NkBp M1T0bolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NYK3OIJUOjF{NEKxPFk>
CHP-212 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[xMVEzPSCwTR?= M{PzdVI1NTF{MDDo NX7VcG5xcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MkjLNlEyPjl{NEK=
IMR-32 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HrSFEuOTJ3IH7N MkDONlQuOTJyIHi= NEnHdpdqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NYPMZYh5OjFzNkmyOFI>
Kelly MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\tPJIxOS1zMkWgcm0> NVTvXmR3OjRvMUKwJIg> Ml71bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MnfVNlEyPjl{NEK=
SH-EP M3;nOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjteHgyNTF{NTDuUS=> MmrQNlQuOTJyIHi= M4DmdolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NGXIb3kzOTF4OUK0Ni=>
SH-SY5Y NIXBcpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XuclEuOTJ3IH7N MYSyOE0yOjBiaB?= MXnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MUmyNVE3QTJ2Mh?=
SK-N-AS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\JR|EuOTJ3IH7N NVfoVJdjOjRvMUKwJIg> MW\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MmTENlEyPjl{NEK=
SK-N-BE MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH1NU0yOjVibl2= MmS4NlQuOTJyIHi= MVHpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NY[1fW1qOjFzNkmyOFI>
KG1 NYnweINDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TMTVEwOTBxMUCwJI5O M4DlSFczKGh? MYrEUXNQ NXexS3RucW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NYXwTWo5OTl2NUizOVg>
U937 NF6xW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXUcJoyNzFyL{GwNEBvVQ>? NULtb|ZoPzJiaB?= MkPKSG1UVw>? MVfpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NEL5T4oyQTR3OEO1PC=>
CAL62 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn6UFkxNjFvMUCwJI5O NF\WbHI4OiCq MVXEUXNQ NHLm[FdGSzVyPUGuOEBvVQ>? M1K1dlE6OjJ|NUWz
OCUT-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fBUFAvOS1zMECgcm0> M3G1R|czKGh? M1\o[2ROW09? MmfvSWM2OD1{LkOgcm0> NYDKNnJ[OTl{MkO1OVM>
8505C MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP4cGsxNjFvMUCwJI5O MWC3NkBp MkDmSG1UVw>? M1LlXmVEPTB;Mz6yJI5O M2ToSFE6OjJ|NUWz
ACT-1 NIXlZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfPR3NmOC5zLUGwNEBvVQ>? MnTTO|IhcA>? NEDmbVRFVVOR M2ruWWVEPTB;NT60JI5O M2S1[FE6OjJ|NUWz
SW1736 NVPQbJBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVOFAvOS1zMECgcm0> MYO3NkBp NIPsbJpFVVOR MUXFR|UxRTVwNjDuUS=> NF;VdW4yQTJ{M{W1Ny=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (40.25 mM)
Water Insoluble
Ethanol '100 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A
Smiles CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID