BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 131 Publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 M1rLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TSfWlEPTB;MD6wNFc4PiEQvF2= NGftSYtUSU6JRWK=
ACN NGHQXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fQSmlEPTB;MD6wNFg1OyEQvF2= NVjkZm97W0GQR1XS
TE-8 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPE[4U5UUN3ME2wMlAxQTRzIN88US=> MnjDV2FPT0WU
LC-2-ad MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\sRXpKSzVyPUCuNFExQTNizszN Mm\0V2FPT0WU
ALL-PO M3zHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEGzJO69VQ>? NUPvPJc{W0GQR1XS
EW-16 NV3ib3RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfQO25KSzVyPUCuNFE{OzZizszN M3r1dHNCVkeHUh?=
KM12 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHv[nNKSzVyPUCuNFE{PDhizszN MoHIV2FPT0WU
GI-1 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHITWM2OD1yLkCxN|g{KM7:TR?= MWfTRW5ITVJ?
LS-411N MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f5NmlEPTB;MD6wNVQxPyEQvF2= NXTOcXFFW0GQR1XS
ES8 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\1TWM2OD1yLkCxOFk1KM7:TR?= NI\hRVlUSU6JRWK=
SNU-C2B NXHkelRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzYTWM2OD1yLkCxOVI3KM7:TR?= NGPuT4tUSU6JRWK=
CESS NHSzNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTJTWM2OD1yLkCxOlAzKM7:TR?= M{D2V3NCVkeHUh?=
697 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEG2Olgh|ryP M4HNTHNCVkeHUh?=
NCI-H1963 M{Xwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEG2O|Mh|ryP MknlV2FPT0WU
IA-LM NUPydpJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrT[W5nUUN3ME2wMlAyPjh6IN88US=> NYqzeFBZW0GQR1XS
SW954 NID2TG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzVTWM2OD1yLkCxO|A2KM7:TR?= M4jPUHNCVkeHUh?=
RL95-2 NYnsc3hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ReWtuUUN3ME2wMlAyPzN6IN88US=> MV;TRW5ITVJ?
LXF-289 M4LneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fMXmlEPTB;MD6wNVc4KM7:TR?= NGTQO|RUSU6JRWK=
OCUB-M M3faSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PlRWlEPTB;MD6wNVgzPiEQvF2= NGLzfZFUSU6JRWK=
RKO NIDBe5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXO[nhUUUN3ME2wMlAyQTh5IN88US=> M3XIXnNCVkeHUh?=
LOUCY MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LOdWlEPTB;MD6wNlA2KM7:TR?= MVvTRW5ITVJ?
NOS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\jTWM2OD1yLkCyNFk{KM7:TR?= M1q1UnNCVkeHUh?=
A4-Fuk M4XsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3foOmlEPTB;MD6wNlIyQCEQvF2= M3;1[nNCVkeHUh?=
A388 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnXOXBKSzVyPUCuNFIzOjdizszN NF7BUWRUSU6JRWK=
TE-9 M{PVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK2UGxKSzVyPUCuNFIzPjFizszN MXnTRW5ITVJ?
KURAMOCHI M1HIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\PUGJHUUN3ME2wMlAzOjh3IN88US=> MkLGV2FPT0WU
KALS-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjkTWM2OD1yLkCyN|M5KM7:TR?= Moq0V2FPT0WU
HOP-62 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnSd3lKSzVyPUCuNFI1OiEQvF2= M3i1c3NCVkeHUh?=
RPMI-8402 NGXRfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34fJBKSzVyPUCuNFI2ODhizszN NIDMOmRUSU6JRWK=
TE-1 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEK1NVIh|ryP NHHJ[2pUSU6JRWK=
CCRF-CEM NVGzdGtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEK1OFMh|ryP MofYV2FPT0WU
HUTU-80 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{niPGlEPTB;MD6wNlYzPCEQvF2= NGfJXYtUSU6JRWK=
NCI-H1648 NIOxc4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXQeJlnUUN3ME2wMlAzPjR5IN88US=> M2j2VHNCVkeHUh?=
HCE-4 M2TpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DXfGlEPTB;MD6wNlY5OiEQvF2= NFe5UZJUSU6JRWK=
ETK-1 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\V[2lEPTB;MD6wNlc{PiEQvF2= NUjJ[WVIW0GQR1XS
TE-15 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Tsc2lEPTB;MD6wNlc{QCEQvF2= M{WydnNCVkeHUh?=
BE-13 M1TtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEK3OEDPxE1? M2\SfnNCVkeHUh?=
KE-37 M1Tpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHjTWM2OD1yLkCyO|QyKM7:TR?= MWfTRW5ITVJ?
NCI-H1355 NE\LWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD1yLkCyO|g{KM7:TR?= MmnUV2FPT0WU
TE-11 NIHQd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH5ZWpxUUN3ME2wMlAzQDB7IN88US=> NUPDW5RXW0GQR1XS
BL-70 M2rKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOzNYxOUUN3ME2wMlAzQDV5IN88US=> MlHsV2FPT0WU
ES6 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL2VoZ2UUN3ME2wMlAzQDhzIN88US=> NVfRdVJSW0GQR1XS
GT3TKB NGTqVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEK5OVMh|ryP MV\TRW5ITVJ?
LB647-SCLC NWLlTY1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESxUoFKSzVyPUCuNFMyQTVizszN MVLTRW5ITVJ?
NB13 MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEOzNVYh|ryP MneyV2FPT0WU
ST486 M1PucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknZTWM2OD1yLkCzN|M4KM7:TR?= M1;Ne3NCVkeHUh?=
NCI-H82 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEOzOFMh|ryP MXjTRW5ITVJ?
NTERA-S-cl-D1 M{HT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XOWGlEPTB;MD6wN|M6QSEQvF2= M4jObHNCVkeHUh?=
ES4 NVz2UodIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m0RWlEPTB;MD6wN|Q3OyEQvF2= NH\VeIJUSU6JRWK=
SK-NEP-1 NFXK[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD1VpFuUUN3ME2wMlA{PDl7IN88US=> M2HuTHNCVkeHUh?=
Becker NXXic3VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDETWM2OD1yLkCzOVU2KM7:TR?= NHriVJNUSU6JRWK=
A101D M3KxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEO3OFgh|ryP MVPTRW5ITVJ?
SK-UT-1 NFHVZlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEO3O|Qh|ryP MmrzV2FPT0WU
SW982 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEO3PUDPxE1? MoHmV2FPT0WU
TE-10 NWHoR246T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HF[WlEPTB;MD6wOFA1PiEQvF2= NXW5WYszW0GQR1XS
OVCAR-4 NI\3cY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi1cJdSUUN3ME2wMlA1ODV7IN88US=> NXHFVVVmW0GQR1XS
KP-N-YS NWXBNHoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLhUpBDUUN3ME2wMlA1ODh3IN88US=> M3;s[nNCVkeHUh?=
BL-41 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6zTWM2OD1yLkC0NVI2KM7:TR?= NYLwNo9DW0GQR1XS
MZ1-PC NVTsXFJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu3TWM2OD1yLkC0NVI4KM7:TR?= NHewOYtUSU6JRWK=
PF-382 NWT6SItOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom5TWM2OD1yLkC0NVk5KM7:TR?= M1jBfXNCVkeHUh?=
MOLT-13 NX;SUnlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGwVY5HUUN3ME2wMlA1OjN6IN88US=> NH2xd4pUSU6JRWK=
HCC1599 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMESyOVgh|ryP MlTXV2FPT0WU
IST-MEL1 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H3bGlEPTB;MD6wOFQ1OiEQvF2= MlX3V2FPT0WU
LU-139 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljLTWM2OD1yLkC0OFQzKM7:TR?= NFvTZYhUSU6JRWK=
MS-1 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILTO|FKSzVyPUCuNFQ4ODFizszN MmXLV2FPT0WU
MFH-ino M2XNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmxXHh[UUN3ME2wMlA2ODB|IN88US=> NIq0PVlUSU6JRWK=
IMR-5 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HCXWlEPTB;MD6wOVAzOSEQvF2= NIjqXYJUSU6JRWK=
TE-5 NV;3fIVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfabXdKSzVyPUCuNFUxPjNizszN M1L5XnNCVkeHUh?=
DJM-1 NYrWZmtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWwOXJKSzVyPUCuNFUyPDJizszN M1rtSnNCVkeHUh?=
NB17 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEWyNFch|ryP NHLsVZZUSU6JRWK=
KARPAS-45 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvLNHAxUUN3ME2wMlA2OzV6IN88US=> NFzZNGxUSU6JRWK=
TGBC1TKB M37Y[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm3bZFpUUN3ME2wMlA2PDB3IN88US=> M3TvdHNCVkeHUh?=
ML-2 M{naW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\hXlVKSzVyPUCuNFU1OTRizszN M2rlcnNCVkeHUh?=
no-10 NHzabGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPVTWM2OD1yLkC1OFc1KM7:TR?= MkLXV2FPT0WU
CTV-1 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\QVohKSzVyPUCuNFU2ODJizszN NVnjd49DW0GQR1XS
SJSA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fwV2lEPTB;MD6wOVUzKM7:TR?= M4Tx[HNCVkeHUh?=
HC-1 NWS2[Y9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEW1PVch|ryP NH;vN2hUSU6JRWK=
TE-12 M2POeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTxTWM2OD1yLkC1OlE{KM7:TR?= MmXMV2FPT0WU
KY821 NXK5bIZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfMV3d5UUN3ME2wMlA2PjN{IN88US=> NHHCenJUSU6JRWK=
TALL-1 NITBRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf1WGlRUUN3ME2wMlA2PzB6IN88US=> M1[yU3NCVkeHUh?=
DEL NHHFW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLQTWM2OD1yLkC1O|A6KM7:TR?= NEj6XlhUSU6JRWK=
TE-6 M2j2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\qc5JKSzVyPUCuNFU4OjJizszN NVfOemZSW0GQR1XS
SK-LMS-1 NYW1S4V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1yLkC1PFA2KM7:TR?= M2GxNnNCVkeHUh?=
EW-1 M3zScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPlT4ZuUUN3ME2wMlA2QDN5IN88US=> M3zSTXNCVkeHUh?=
8-MG-BA MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjle2RqUUN3ME2wMlA2QDVzIN88US=> NEDWdYtUSU6JRWK=
NALM-6 NFizT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjxVI5KSzVyPUCuNFU6PzNizszN M4[3b3NCVkeHUh?=
LB771-HNC NF65SmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjU[GVDUUN3ME2wMlA2QTd7IN88US=> NWT2WmROW0GQR1XS
HT-144 NGHkWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\JNmlEPTB;MD6wOlE{KM7:TR?= M1vJPXNCVkeHUh?=
KM-H2 M3jhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\YS2VjUUN3ME2wMlA3OjJzIN88US=> NGHGS2xUSU6JRWK=
SF268 NW\VVopRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMVGFPUUN3ME2wMlA3Ojh4IN88US=> MkXqV2FPT0WU
RS4-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVi3foNUUUN3ME2wMlA3OzB2IN88US=> MljwV2FPT0WU
MHH-PREB-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH2UZR4UUN3ME2wMlA3OzF7IN88US=> MmLLV2FPT0WU
ATN-1 M2jnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrUfVdKSzVyPUCuNFY{PDVizszN M4PNRXNCVkeHUh?=
BB30-HNC MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzGTWM2OD1yLkC2OFM3KM7:TR?= MlrHV2FPT0WU
CPC-N MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;IR2lEPTB;MD6wOlUzPCEQvF2= NFnOToZUSU6JRWK=
NB1 MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDRWld5UUN3ME2wMlA3PjF|IN88US=> MUnTRW5ITVJ?
KS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwME[3OFgh|ryP NFuxOYRUSU6JRWK=
RXF393 NWjMVHJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX74cHVUUUN3ME2wMlA3PzZ2IN88US=> NVTGWHh7W0GQR1XS
IST-SL2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEewNFQh|ryP NEnC[FNUSU6JRWK=
GI-ME-N MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjISm5KSzVyPUCuNFczQDZizszN MVTTRW5ITVJ?
VA-ES-BJ NYe2UXhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXnTWM2OD1yLkC3OFc2KM7:TR?= NFu1c5JUSU6JRWK=
NCI-H1581 M{LIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvUeIVKSzVyPUCuNFc1PzhizszN MVXTRW5ITVJ?
U-266 NIDqRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvMTWM2OD1yLkC3OFk4KM7:TR?= MYTTRW5ITVJ?
DMS-114 NGjEcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEe1Nlgh|ryP M1e0ZnNCVkeHUh?=
NCI-H187 NF\tOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H6V2lEPTB;MD6wO|czPiEQvF2= M37COHNCVkeHUh?=
SW962 NVzib2RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2qxVGlEPTB;MD6wO|g{QSEQvF2= MkW2V2FPT0WU
MONO-MAC-6 M3P1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\XUIZKSzVyPUCuNFc6QDZizszN NGG5enRUSU6JRWK=
MOLT-16 M2eyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5UJdKSzVyPUCuNFgyOjFizszN MXnTRW5ITVJ?
KNS-42 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r5O2lEPTB;MD6wPFE3OSEQvF2= MlTjV2FPT0WU
CMK M2rEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPtTWM2OD1yLkC4NlI2KM7:TR?= NXHnWWtZW0GQR1XS
Ramos-2G6-4C10 M1Hmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTHSoNKSzVyPUCuNFgzOjVizszN NEfTXpJUSU6JRWK=
Daudi M3rMemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PtW2lEPTB;MD6wPFI2PiEQvF2= M{nKZ3NCVkeHUh?=
NCI-H510A M4W1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rnXGlEPTB;MD6wPFM{PiEQvF2= MXXTRW5ITVJ?
LB831-BLC NHGwc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEi1OlEh|ryP M4q5NXNCVkeHUh?=
HEL MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG5T2VKSzVyPUCuNFg3PjhizszN MmGyV2FPT0WU
LU-134-A M3zxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEi3NFgh|ryP MnX4V2FPT0WU
NCI-H1694 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEi3OFQh|ryP MWXTRW5ITVJ?
KGN M1:1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPsbo43UUN3ME2wMlA5PzV7IN88US=> NHrGbYdUSU6JRWK=
A253 NHTDS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEi4NlIh|ryP MlO3V2FPT0WU
DG-75 M3HST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLZ3RGUUN3ME2wMlA5QTJ{IN88US=> M4rCV3NCVkeHUh?=
MOLT-4 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEi5PFMh|ryP MYnTRW5ITVJ?
NCI-SNU-5 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTvTWM2OD1yLkC5NlU5KM7:TR?= M{C0NXNCVkeHUh?=
ONS-76 Mm[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;nUHRnUUN3ME2wMlA6Ojd4IN88US=> NFLOUXpUSU6JRWK=
NCI-H446 M1q1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEm0OlIh|ryP NVHWTWplW0GQR1XS
COR-L279 NX\jd5ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX4bW1mUUN3ME2wMlA6PTV4IN88US=> MWDTRW5ITVJ?
Calu-6 M1rsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEm1PVgh|ryP M{LFWnNCVkeHUh?=
BC-3 M4HlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHmTWM2OD1yLkC5OlYzKM7:TR?= MmXxV2FPT0WU
NCI-H2126 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH5TWM2OD1yLkC5O|kyKM7:TR?= NFrOPYFUSU6JRWK=
NCI-H1882 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPKXYFkUUN3ME2wMlA6QDB7IN88US=> M1jwT3NCVkeHUh?=
BB65-RCC M3Lifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjpTWM2OD1yLkGwNlk1KM7:TR?= NGHQPYlUSU6JRWK=
DU-4475 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zqcGlEPTB;MD6xNFQxPyEQvF2= MnfCV2FPT0WU
NCI-H526 MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLlTWM2OD1yLkGwOFQh|ryP M{HnSnNCVkeHUh?=
NEC8 Mmr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUC1NlUh|ryP NGPWPWRUSU6JRWK=
NCI-H1304 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOxOGFKSzVyPUCuNVA2QTRizszN MoTHV2FPT0WU
L-540 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW2UIhKSzVyPUCuNVA4ODhizszN MUXTRW5ITVJ?
NCI-SNU-16 NIPZWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfYVZRGUUN3ME2wMlExPzR{IN88US=> MlvOV2FPT0WU
HD-MY-Z MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnafYdVUUN3ME2wMlExQDV4IN88US=> M1;wOHNCVkeHUh?=
K-562 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\tfHBvUUN3ME2wMlExQDV6IN88US=> NVzOdJM6W0GQR1XS
JAR MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUC5NlUh|ryP M3;1OHNCVkeHUh?=
MZ2-MEL NXHNc2IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMUGwOUDPxE1? NF;UWlFUSU6JRWK=
L-363 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3YTWM2OD1yLkGxNFc6KM7:TR?= NX\1SYdDW0GQR1XS
BV-173 NYCwb5l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LYOGlEPTB;MD6xNVI1OyEQvF2= NVLhR4djW0GQR1XS
NCI-H524 NIXhUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD1yLkGxNlc1KM7:TR?= NHi0VXBUSU6JRWK=
EoL-1-cell NYryfIRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\K[VRrUUN3ME2wMlEyPjd{IN88US=> NHTuWoNUSU6JRWK=
K052 NHr0XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnz[WVGUUN3ME2wMlEyPzF{IN88US=> NWjxe|hrW0GQR1XS
TK10 NVrke|VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XCUWlEPTB;MD6xNVczQCEQvF2= MUDTRW5ITVJ?
KU812 NF\4VoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PKUGlEPTB;MD6xNlA1PCEQvF2= NHu3cmJUSU6JRWK=
RPMI-8226 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\UTFRnUUN3ME2wMlEzODV{IN88US=> Mli0V2FPT0WU
MZ7-mel MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vqe2lEPTB;MD6xNlI{PyEQvF2= MWTTRW5ITVJ?
SK-PN-DW NIm0TmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LyO2lEPTB;MD6xNlI5PyEQvF2= NXW5cpFCW0GQR1XS
SR NVH5OpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r3fWlEPTB;MD6xNlQ1OSEQvF2= M4jZb3NCVkeHUh?=
RPMI-6666 M3LIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojFTWM2OD1yLkGyO|Q{KM7:TR?= MlLUV2FPT0WU
no-11 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;lXFJKSzVyPUCuNVI5PjlizszN NXr2cmdTW0GQR1XS
EW-3 M4CySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;tTWM2OD1yLkGyPFk{KM7:TR?= MX3TRW5ITVJ?
LAMA-84 NGPpPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMUOxPFch|ryP NXntcJllW0GQR1XS
HT NX3CdY9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK1NVJKSzVyPUCuNVM2PzRizszN M{XzUXNCVkeHUh?=
KP-N-RT-BM-1 NILI[VZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13UVmlEPTB;MD6xN|YyOiEQvF2= NVXBd5NLW0GQR1XS
NCI-H747 M{f2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMUO3JO69VQ>? M{\wSnNCVkeHUh?=
NCCIT Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUO5N|kh|ryP NXT3Z4FiW0GQR1XS
MLMA M{G5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMUSxOlch|ryP NGDUVlFUSU6JRWK=
LP-1 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XKcWlEPTB;MD6xOFI1KM7:TR?= M1nVTXNCVkeHUh?=
CAL-148 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\VS|FnUUN3ME2wMlE1PDh|IN88US=> NYWzfFAyW0GQR1XS
GB-1 NXjIVpFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDofJZKSzVyPUCuNVQ2OjZizszN M2\XcXNCVkeHUh?=
COR-L88 NWTue4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\DTWM2OD1yLkG0PFAzKM7:TR?= NXy3[FhoW0GQR1XS
NKM-1 NG\SOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTDTWM2OD1yLkG0PVA3KM7:TR?= M13xWnNCVkeHUh?=
NB5 M1Tk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[ydWlEPTB;MD6xOVQ3OiEQvF2= NIH0TmZUSU6JRWK=
SH-4 M4TMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMUW0OlYh|ryP NUSz[no6W0GQR1XS
EM-2 MkP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH4UnNKSzVyPUCuNVU1PjdizszN NXrYXoVLW0GQR1XS
TGBC24TKB NH32PZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjvVFgyUUN3ME2wMlE2PjV7IN88US=> NIHvflVUSU6JRWK=
SCLC-21H NWfmN4JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPOUmdKSzVyPUCuNVU4ODJizszN NXS2NlJTW0GQR1XS
COLO-684 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXvVod5UUN3ME2wMlE2PzJzIN88US=> NI[weZZUSU6JRWK=
KINGS-1 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe0dIRrUUN3ME2wMlE2QTFizszN NGKxTo9USU6JRWK=
LS-123 NXPBcmJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Lub2lEPTB;MD6xOVkyPyEQvF2= NGP1O4ZUSU6JRWK=
MC116 M4P6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XVeGlEPTB;MD6xOlE2QCEQvF2= MUDTRW5ITVJ?
SU-DHL-1 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;QTWM2OD1yLkG2NlA3KM7:TR?= M{[1XXNCVkeHUh?=
NCI-H64 NH7zc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMU[zOFch|ryP MXjTRW5ITVJ?
HCE-T MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrQTWM2OD1yLkG2OVA1KM7:TR?= MUjTRW5ITVJ?
LOXIMVI M2Dwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQVIRqUUN3ME2wMlE3QTR7IN88US=> M2TCS3NCVkeHUh?=
ARH-77 NGjuNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DNSmlEPTB;MD6xO|M4QSEQvF2= NVHpTmRuW0GQR1XS
DOHH-2 NI\HWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnj[lF5UUN3ME2wMlE4Pjd{IN88US=> MWLTRW5ITVJ?
COLO-320-HSR M1vEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXITWM2OD1yLkG4NVU1KM7:TR?= MWXTRW5ITVJ?
NB6 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjrT2VKSzVyPUCuNVg2PjZizszN NUXZPVB[W0GQR1XS
L-428 NF3ZZVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDHOZViUUN3ME2wMlE5QDF|IN88US=> M{nZenNCVkeHUh?=
SNB75 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\OS2lEPTB;MD6xPFgzPCEQvF2= NGfQeXpUSU6JRWK=
NCI-H2141 NWPZNFJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMUmwNVEh|ryP M3;JSHNCVkeHUh?=
KARPAS-299 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMUmyOFEh|ryP NXTIUoV{W0GQR1XS
LC4-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjqVoRMUUN3ME2wMlE6PTB{IN88US=> M{\GPXNCVkeHUh?=
UACC-257 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXtOYVkUUN3ME2wMlE6QTR5IN88US=> MXzTRW5ITVJ?
EVSA-T NF;4fVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnqeHVKSzVyPUCuNlA{OTJizszN NHKxVFVUSU6JRWK=
JiyoyeP-2003 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMkC0O|ch|ryP M2rhSXNCVkeHUh?=
NCI-H720 MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMkC1NlUh|ryP Mlz6V2FPT0WU
GAK M1zrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITxSWZKSzVyPUCuNlEyQDlizszN NEm2TXpUSU6JRWK=
HH MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDQZWpyUUN3ME2wMlIyPDB3IN88US=> MmPkV2FPT0WU
NCI-H1436 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMkG0OlQh|ryP Ml3ZV2FPT0WU
GR-ST Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPqWo5KSzVyPUCuNlE1QDhizszN MkLDV2FPT0WU
BC-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP6XJF1UUN3ME2wMlIzPjF4IN88US=> NIPHZ5FUSU6JRWK=
SIG-M5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS5TWM2OD1yLkKyO|I4KM7:TR?= MX\TRW5ITVJ?
NCI-H345 M{H5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3RZ|d2UUN3ME2wMlI{QDB3IN88US=> NUTmbVhoW0GQR1XS
OPM-2 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfwPFJIUUN3ME2wMlI{QDh{IN88US=> MoHqV2FPT0WU
LB1047-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMkS0NUDPxE1? MlHxV2FPT0WU
CTB-1 NHHBc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMkS0PVMh|ryP NX21VoxnW0GQR1XS
A3-KAW NH7Zb2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLNeXl{UUN3ME2wMlI2OzRzIN88US=> M{Dye3NCVkeHUh?=
SF126 M1nWNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnXflRKSzVyPUCuNlU{QDNizszN NGL0cXZUSU6JRWK=
KARPAS-422 M32xXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nNb2lEPTB;MD6yOVQ{PSEQvF2= NH:2O3FUSU6JRWK=
MEG-01 M3PWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTrfWlTUUN3ME2wMlI2Pjd|IN88US=> NWToNHJ1W0GQR1XS
NCI-H209 NYmwW4VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMk[zO|Qh|ryP MVfTRW5ITVJ?
SBC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzGZoplUUN3ME2wMlI3PSEQvF2= MlLlV2FPT0WU
K5 NYHkUWhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m3bWlEPTB;MD6yOlk5PCEQvF2= NXLzSI5ZW0GQR1XS
QIMR-WIL M4\6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rjeWlEPTB;MD6yO|E2PSEQvF2= NXf4O|dSW0GQR1XS
NMC-G1 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMkiyNVch|ryP NFzvdoZUSU6JRWK=
IST-MES1 M{DFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH5TWM2OD1yLkK5NlM5KM7:TR?= NGW5Nm5USU6JRWK=
SW684 NYTJR3h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37xcGlEPTB;MD6zNFA1PyEQvF2= M4izOXNCVkeHUh?=
MV-4-11 NYfhVZRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwM{C3PFgh|ryP MVzTRW5ITVJ?
LAN-6 M4fDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwM{G1O|Ih|ryP MYrTRW5ITVJ?
RH-1 NGDScIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\1VWlEPTB;MD6zNVg4OSEQvF2= MV3TRW5ITVJ?
CP66-MEL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwM{G4O|gh|ryP MlqyV2FPT0WU
EC-GI-10 M1q3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrEfXVbUUN3ME2wMlMzQTh5IN88US=> MnzGV2FPT0WU
GDM-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr1TWM2OD1yLkOzNFU6KM7:TR?= NEfWVHNUSU6JRWK=
IST-SL1 NY\heJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwM{S5NVQh|ryP MmDRV2FPT0WU
KMOE-2 NYHXcVI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm2fGR6UUN3ME2wMlM2OTd3IN88US=> Mm\PV2FPT0WU
OS-RC-2 NHXuWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;kZoNKSzVyPUCuN|U2PDRizszN MWXTRW5ITVJ?
HDLM-2 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHLTWM2OD1yLkO3PFE1KM7:TR?= M{e3Z3NCVkeHUh?=
DSH1 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIGxSlFKSzVyPUCuN|g3OzFizszN NG[wOGlUSU6JRWK=
LS-1034 M2HCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rlSGlEPTB;MD6zPFk2PCEQvF2= NYDT[o1sW0GQR1XS
LB373-MEL-D NUfsT2xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi5T4RKSzVyPUCuN|kyQTdizszN M2HjcHNCVkeHUh?=
GOTO M{PUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHLXItHUUN3ME2wMlQzOTF6IN88US=> M1HqUXNCVkeHUh?=
MRK-nu-1 NYXLUIlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULqSlZqUUN3ME2wMlQzOjB3IN88US=> NX3XXWJrW0GQR1XS
SK-MM-2 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;RTWM2OD1yLkSzOFQzKM7:TR?= NHPkXVJUSU6JRWK=
BOKU M{HVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQ[FlKSzVyPUCuOFM4QTJizszN NUO4UXdzW0GQR1XS
NOMO-1 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7hV2ZPUUN3ME2wMlQ{QDZizszN NYDhbWRMW0GQR1XS
J-RT3-T3-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7DTWM2OD1yLkS0PFc5KM7:TR?= MXPTRW5ITVJ?
COLO-668 NGXCOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\vTGlEPTB;MD60OVY3QCEQvF2= NX\2ZmNmW0GQR1XS
SF539 NFfVc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\IfWlEPTB;MD60PFY5PCEQvF2= NFryVmxUSU6JRWK=
LB2518-MEL M2DxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BXFBKSzVyPUCuOFk4ODNizszN Mn;FV2FPT0WU
TE-441-T NVvWUWR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwNUCxNkDPxE1? NYXuZoF5W0GQR1XS
MDA-MB-134-VI NX30[HRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPxPFFKSzVyPUCuOVA6OjFizszN MULTRW5ITVJ?
SCC-3 NYXTe4pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwNUG4O|Mh|ryP NYiweFNzW0GQR1XS
KLE MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNUKxO|Eh|ryP MXLTRW5ITVJ?
LB2241-RCC NF;TXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm1R2ZKSzVyPUCuOVI2OjVizszN MnnkV2FPT0WU
NCI-H1417 M{e1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwNUO0N|Uh|ryP NFPFUpJUSU6JRWK=
NCI-H2081 M2fvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwNUi2NVEh|ryP M4SyXXNCVkeHUh?=
NCI-H1522 MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELIOnpKSzVyPUCuOVk{QDNizszN NW\nTWRSW0GQR1XS
NCI-H889 M1nDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX2bG46UUN3ME2wMlU6QDR2IN88US=> M13veXNCVkeHUh?=
CGTH-W-1 NV20WVc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTjTWM2OD1yLk[wO|U2KM7:TR?= Mln1V2FPT0WU
EB-3 M4TJdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;XeG1KSzVyPUCuOlEyPTNizszN MWDTRW5ITVJ?
D-336MG NF\EfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnoXppKSzVyPUCuOlE4QTFizszN MXHTRW5ITVJ?
LC-1F NWL5XlJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvdZRKSzVyPUCuOlI2QTJizszN NEPzOlhUSU6JRWK=
MHH-NB-11 NEHsPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\JU2lEPTB;MD62N|gxOSEQvF2= NYn4RZFsW0GQR1XS
SK-N-FI NX3wWIVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrSTWM2OD1yLk[zPVEh|ryP M{K5VnNCVkeHUh?=
NCI-H69 NY\RfJE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fjc2lEPTB;MD62OFg4QSEQvF2= NE\QTI5USU6JRWK=
SCH MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNk[wNlMh|ryP Mn\HV2FPT0WU
LS-513 NIrkenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwNkeyOVkh|ryP MnzTV2FPT0WU
CP67-MEL NILJW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNke1PVYh|ryP MUjTRW5ITVJ?
GCIY MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjnRmE1UUN3ME2wMlcxOzZ|IN88US=> NGLO[3hUSU6JRWK=
SHP-77 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwN{C3N|Qh|ryP NVjHXoJWW0GQR1XS
EHEB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f0R2lEPTB;MD63NVg2PCEQvF2= NUXLOHdNW0GQR1XS
D-247MG M3ruRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\ofoFKSzVyPUCuO|MzOzJizszN NYHUZ3NEW0GQR1XS
Raji M1j1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwN{S5PFkh|ryP M3H3fnNCVkeHUh?=
MPP-89 M1fub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLuTWM2OD1yLke1PVc5KM7:TR?= MYHTRW5ITVJ?
EKVX M4jGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwN{mwO|Mh|ryP M4fCenNCVkeHUh?=
HCC2218 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj6coxxUUN3ME2wMlc6OTNzIN88US=> MkPSV2FPT0WU
KNS-81-FD NV:z[ms5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwOEGwNVEh|ryP M1vnRnNCVkeHUh?=
HCC2157 MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonlTWM2OD1yLki0PVUyKM7:TR?= NV30cHoxW0GQR1XS
BT-474 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL3TWM2OD1yLki4PFU1KM7:TR?= M4fx[HNCVkeHUh?=
NCI-H748 NWLlZVc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nITGlEPTB;MD65NVIh|ryP NXnTe2dFW0GQR1XS
EW-24 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7zfIdKSzVyPUCuPVIxODJizszN MXnTRW5ITVJ?
D-263MG Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\XS4pYUUN3ME2wMlk1PTF{IN88US=> MXfTRW5ITVJ?
OMC-1 M2D4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwOU[zO|Mh|ryP M1znZnNCVkeHUh?=
NCI-H2196 NWfTR4l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH1TWM2OD1yLkm3O|c4KM7:TR?= MUTTRW5ITVJ?
HAL-01 NUPYd|VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn6yTWM2OD1yLkm5PFczKM7:TR?= MoriV2FPT0WU
NCI-H2107 M3XwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m3S2lEPTB;MT6wNVg2PCEQvF2= M4PJZ3NCVkeHUh?=
LB996-RCC NVnIXlloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr4[pBKSzVyPUGuNFgxPTFizszN NVLKZWlyW0GQR1XS
NCI-H1395 MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnDTWM2OD1zLkGwOlch|ryP NHT6cXRUSU6JRWK=
CHP-126 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwMU[xPVkh|ryP MoHKV2FPT0WU
NB69 M1\3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml72TWM2OD1zLkK2NVQ5KM7:TR?= NVjiWZZsW0GQR1XS
CAS-1 NIPudGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHtOG17UUN3ME2xMlM1OjNzIN88US=> MUfTRW5ITVJ?
JVM-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jhNmlEPTB;MT60O|g2PSEQvF2= NXjUNoNnW0GQR1XS
DMS-153 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES3ZlFKSzVyPUGuOVc3PzRizszN MlHTV2FPT0WU
SK-MEL-2 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwN{G3PFkh|ryP NYrKO5FpW0GQR1XS
NCI-H1155 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwN{O2O|Yh|ryP MX\TRW5ITVJ?
NCI-H1092 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPXZ2VKSzVyPUGuO|YyQDJizszN MoHvV2FPT0WU
LU-165 NWjlNWpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwOE[0O|Yh|ryP NH:0O41USU6JRWK=
HL-60 NGDtU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr3c4xKSzVyPUGuPVk6ODhizszN NF;rboVUSU6JRWK=
REH NIm2b2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Thd2lEPTB;Mj6wNFU5OiEQvF2= NX:zU4ZCW0GQR1XS
JVM-2 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG4WVRKSzVyPUKuNFYyOzVizszN M{TXXnNCVkeHUh?=
MN-60 NEfYepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfQSmNKSzVyPUKuNVc{ODhizszN MYjTRW5ITVJ?
SCC-15 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLrTWM2OD1{LkKwNlch|ryP NYHMV|dJW0GQR1XS
SNU-C1 M{\4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle4TWM2OD1{LkKxN|Q{KM7:TR?= NITpTnpUSU6JRWK=
SK-MEL-1 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn6Z5B[UUN3ME2yMlMzODR5IN88US=> NEPOcXNUSU6JRWK=
TGW NHvWW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LFfGlEPTB;Mj6zOVAzPyEQvF2= MkDzV2FPT0WU
CA46 NHjrV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwN{W5Olch|ryP M3rOXHNCVkeHUh?=
NCI-H23 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnteZBmUUN3ME2yMlgxPzlzIN88US=> MWTTRW5ITVJ?
MMAC-SF NUPVZpgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPVNI9KSzVyPUKuPFY3OjhizszN MoHuV2FPT0WU
NCI-H2171 NIHUZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrZTWM2OD1|LkCzOFQ5KM7:TR?= NIHxXIhUSU6JRWK=
A704 Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDlTWM2OD1|LkG0NVk1KM7:TR?= NIeye4VUSU6JRWK=
DB M4ewWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\PTWM2OD1|LkK1OVc3KM7:TR?= MV3TRW5ITVJ?
NCI-H719 M1n1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwM{CzPFQh|ryP M1XuR3NCVkeHUh?=
MC-CAR NWXXeVF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\vTWM2OD1|LkW0PFE4KM7:TR?= M4rXTHNCVkeHUh?=
SIMA MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnVTWM2OD1|LkW4OFE3KM7:TR?= MVPTRW5ITVJ?
SW872 NVLl[FVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn5TWM2OD1|Lke4NVAyKM7:TR?= MYnTRW5ITVJ?
HCC1187 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHQTWM2OD1|Lke4N|E2KM7:TR?= MU\TRW5ITVJ?
EW-13 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqwPZRvUUN3ME2zMlg{PDF5IN88US=> M3jOVXNCVkeHUh?=
NCI-SNU-1 NUHESlFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTRwMkG5PVkh|ryP NHLiO3BUSU6JRWK=
NCI-H226 M2TqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonCTWM2OD12LkOzOlA3KM7:TR?= MlvzV2FPT0WU
RPMI-8866 M4jYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfNRWRKSzVyPUSuN|YxOjlizszN NVnCN|V1W0GQR1XS
OCI-AML2 MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLaTWM2OD12LkW1NlMh|ryP M3\ZVXNCVkeHUh?=
LU-65 M1u2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDI[ZpKUUN3ME20Mlk{ODN|IN88US=> MXHTRW5ITVJ?
SK-N-DZ MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTVwNkO0OlUh|ryP NH[4N|dUSU6JRWK=
NB14 NVX1co1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLTZ2U2UUN3ME21Mlk4OTN3IN88US=> M3iwVXNCVkeHUh?=
COLO-829 NGLFTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[2XFNKSzVyPU[uN|M{PTlizszN NY\YcmRbW0GQR1XS
MHH-CALL-2 M3zVTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTZwNUG1NFgh|ryP MlPTV2FPT0WU
NCI-H1770 NUnaN5RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH1TWM2OD14Lk[2PVA1KM7:TR?= M1LBUHNCVkeHUh?=
ECC4 NF7D[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrYTWM2OD14LkiyNVc6KM7:TR?= MXHTRW5ITVJ?
A498 NVizeVc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTZwOEexPVIh|ryP Mnq0V2FPT0WU
DMS-79 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSwTolKSzVyPUeuNFQ2OTJizszN MWDTRW5ITVJ?
P30-OHK NWKxXJRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n3UGlEPTB;Nz6yNVkxPiEQvF2= NUHOVGhPW0GQR1XS
D-502MG M4DJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTdwOUizOkDPxE1? MonKV2FPT0WU
RCC10RGB MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRThwME[yPEDPxE1? MXTTRW5ITVJ?
U-698-M MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXaXJVKSzVyPUiuNlkzOjZizszN NVnVZnZrW0GQR1XS
BB49-HNC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P0XmlEPTB;OT60NlI3PSEQvF2= NXPOfHpqW0GQR1XS
ES1 NXnKOpdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXtTFl1UUN3ME25MlY5QTV4IN88US=> NWK0[pF7W0GQR1XS
MFM-223 NEHIZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\VTWM2OD1zMD65PVI4KM7:TR?= NH7NWXVUSU6JRWK=
C2BBe1 NY\2WllVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfxTWM2OD1zMT6zOVI{KM7:TR?= NFnmdGFUSU6JRWK=
EB2 M1SycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\J[WlEPTB;MUKuOlg5OSEQvF2= NUXieZg2W0GQR1XS
C8166 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzsTWM2OD1zMz64N|A{KM7:TR?= NXrz[21tW0GQR1XS
ES3 NV;YdHV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33xc2lEPTB;MUOuPVk4PyEQvF2= M1;hTHNCVkeHUh?=
NCI-H1650 NETlTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDqVmNkUUN3ME2xOk4{PzZ3IN88US=> MUXTRW5ITVJ?
Mo-T NF3mWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ad2lEPTB;MUeuOFAzQSEQvF2= MkLPV2FPT0WU
NB7 NGTQUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT5OHRLUUN3ME2xO{44PDZ5IN88US=> NIXyNWVUSU6JRWK=
ES7 NX\OUXZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fLcWlEPTB;MUmuOVUxPyEQvF2= Mn3aV2FPT0WU
ES5 NHzVc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJzLke2O|Eh|ryP Ml;rV2FPT0WU
MSTO-211H NWTX[W5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37JPGlEPTB;MkGuPFg2QCEQvF2= NVPyRpd6W0GQR1XS
U-87-MG NHTpb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPqPIx5UUN3ME2yOU4yQTZ4IN88US=> M4K5UnNCVkeHUh?=
THP-1 M33XUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLsOFVKUUN3ME2yPU44OjBzIN88US=> NFP3THBUSU6JRWK=
NB10 NVrwNmZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jUS2lEPTB;M{CuNlY6PCEQvF2= NE\mbWVUSU6JRWK=
NH-12 MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN|LkKwNVch|ryP M4rpcXNCVkeHUh?=
COLO-824 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfTTWM2OD1|ND6xNFA3KM7:TR?= MnnpV2FPT0WU
SKM-1 NEDRWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPyUFVKSzVyPUO3Mlg1OjJizszN Mn7PV2FPT0WU
NCI-H1838 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz2UpJMUUN3ME2zPE4{Pzl5IN88US=> M4HnenNCVkeHUh?=
RL M3HTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjBTWM2OD1|OT6yOFc4KM7:TR?= M2nsOnNCVkeHUh?=
COLO-800 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ITWM2OD12MD6wO|c{KM7:TR?= NGnvVWhUSU6JRWK=
KG-1 MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:2d2lEPTB;NECuPFk2PSEQvF2= NH20UZBUSU6JRWK=
TUR NGTlO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTRzLk[zPVkh|ryP MoO1V2FPT0WU
LNCaP-Clone-FGC M3fLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDOdpdKSzVyPUSxMlkxOTdizszN MWTTRW5ITVJ?
NCI-H322M NVXS[o5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrUVYhJUUN3ME20Nk42QTh2IN88US=> MoPLV2FPT0WU
LNCaP  MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLyfldnUUN3ME25NU4{KG6P NWTiXYozOjV3MEWxO|Q>
C4-2 NWXxNXNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRThibl2= NHXWZXozPTVyNUG3OC=>
JURKAT NU\HfZF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUGyOEBp MmnmTWM2OD12MU[uOlYhdk1? M135d|I1PTF7OUm1
MOLT-4 NE\NRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDBNlQhcA>? MoCzTWM2OD1{OEWzMlUhdk1? NXP2SIxkOjR3MUm5PVU>
REH NWHUOYIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCyOEBp MVHJR|UxRTJ6Nz62PEBvVQ>? Mo\sNlQ2OTl7OUW=
NALM-6 NYfscYdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmyOEBp NUHpe|I2UUN3ME2zOFM{OCCwTR?= M1LqSlI1PTF7OUm1
RS 4;11 NFSxOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm0NlQhcA>? MUnJR|UxRTVzOT6wOUBvVQ>? NGr0NJQzPDVzOUm5OS=>
697 NUHRcYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q1VlI1KGh? MYjJR|UxRTJzMEeuNUBvVQ>? MXiyOFUyQTl7NR?=
SIL-ALL NF7wNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ThTVI1KGh? MWXJR|UxRTF7OT63O{BvVQ>? Mn7zNlQ2OTl7OUW=
CEM Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO0b|IzPCCq MX\JR|UxRTV{LkG4JI5O NFflfJozPDVzOUm5OS=>
P12 M2jFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Dn[FI1KGh? MYDJR|UxRTN7LkK3JI5O MWWyOFUyQTl7NR?=
NALM-16 M1z2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2raeFI1KGh? MmHrTWM2OD17Nj6yPEBvVQ>? Mlm0NlQ2OTl7OUW=
JURKAT M2rnWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWG0PEBp MlXiTWM2OD1zND64OEBvVQ>? NVX4fpVmOjR3MUm5PVU>
MOLT-4 NYDkOFJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnROFghcA>? M321N2lEPTB;Mk[uOkBvVQ>? NXG2[2NVOjR3MUm5PVU>
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SIL-ALL NGXITGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GwPVQ5KGh? MmrwTWM2OD15ND62NkBvVQ>? M1fDVFI1PTF7OUm1
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CORL-23/R MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfrdYhPUUN3ME21MlE3KMLzIEGuPFMhdk1? M{nyTFI{QTZ{NES1
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pcDNA-HEK293 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwN{WgxtEhOC54NzDuUS=> Mn;oNlM6PjJ2NEW=
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MRP1-HEK293 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnNOmF6UUN3ME2yMlk6KMLzIEGuOFkhdk1? MXiyN|k3OjR2NR?=
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KB-V1  MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNwOUKg{txO MlzLNlM2QTNzOU[=
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Wittier M3\CUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXpO|IhcA>? MXPJR|UxRTNwMk[gcm0> Mm\BNlE6PjV5M{m=
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Caki-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL6T3Y3PS16MDDuUS=> NFHqeFc6PiCq MWPIR4w> MnHxd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P MYmyNVY1OjN5NB?=
SN12C MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWi1MVgxKG6P M{Tpblk3KGh? MVPIR4w> MnnId5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P M4fleVIyPjR{M{e0
HMC-1.1 M1ryVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDuVWgyNTFyMECgcm0> NEXMUnQ4OiCq M3PYeolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? MmqzNlEzPDJzOEm=
HMC-1.2 M1PqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKzNU0yODByIH7N Ml3NO|IhcA>? NU[ybHd6cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MWqyNVI1OjF6OR?=
C2 M13HNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jVfFEuOTByMDDuUS=> Mk\hO|IhcA>? M2DsdIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NU\xR5ptOjF{NEKxPFk>
CHP-212 NEXDRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rVNFEuOTJ3IH7N MW[yOE0yOjBiaB?= MoHxbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MWOyNVE3QTJ2Mh?=
IMR-32 NFzIRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\PNU0yOjVibl2= NUDYZXVTOjRvMUKwJIg> NYXmVHRwcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MYqyNVE3QTJ2Mh?=
Kelly NEXzcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXMS40yNTF{NTDuUS=> MWSyOE0yOjBiaB?= NHThXVNqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M3nB[lIyOTZ7MkSy
SH-EP MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO0NU0yOjVibl2= MlTMNlQuOTJyIHi= MXjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M4OyXVIyOTZ7MkSy
SH-SY5Y NHLVXVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLJPI5QOS1zMkWgcm0> MUWyOE0yOjBiaB?= M3;uZYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NEDZV2czOTF4OUK0Ni=>
SK-N-AS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPWTIUyNTF{NTDuUS=> NHzoe4kzPC1zMkCgbC=> MX7pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MY[yNVE3QTJ2Mh?=
SK-N-BE M4nWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSxMVEzPSCwTR?= M{Xob|I1NTF{MDDo MXzpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NIr2[XEzOTF4OUK0Ni=>
KG1 NVzqSINQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfhNpcyNzFyL{GwNEBvVQ>? M134[|czKGh? NVfPWI9PTE2VTx?= MknUbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NWrZS21lOTl2NUizOVg>
U937 NYjFdZRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj0UJFoOS9zMD:xNFAhdk1? MofFO|IhcA>? M2HDb2ROW09? NHe0VFNqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NXPMXHVnOTl2NUizOVg>
CAL62 M3Hwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\PdXpuOC5zLUGwNEBvVQ>? NWOz[4FFPzJiaB?= M{\BZmROW09? NHLOeJlGSzVyPUGuOEBvVQ>? M1zWZ|E6OjJ|NUWz
OCUT-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6wMlEuOTByIH7N Mm\3O|IhcA>? MWDEUXNQ M4DSTWVEPTB;Mj6zJI5O NXfGbmhROTl{MkO1OVM>
8505C M3PKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKwMlEuOTByIH7N NXrQeIFvPzJiaB?= M1H3RmROW09? M4PSTWVEPTB;Mz6yJI5O Mn\JNVkzOjN3NUO=
ACT-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjMNnlpOC5zLUGwNEBvVQ>? MXO3NkBp M1\JfWROW09? M3z4R2VEPTB;NT60JI5O NVPVRnRYOTl{MkO1OVM>
SW1736 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUSwMlEuOTByIH7N NEjZWmc4OiCq Ml;lSG1UVw>? NHziTGpGSzVyPUWuOkBvVQ>? MlPMNVkzOjN3NUO=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID