BI 2536

Name: BI 2536
Brand: Selleck Chemicals
SKU: S1109
Rating: 5 (249 reviews)

For research use only.

Catalog No.S1109

249 publications

CAS No. 755038-02-9

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

Selleck's BI 2536 has been cited by 249 publications

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2010, 18(6):641-54

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Nat Commun, 2021, 12(1):5356

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Cancer Res, 2021, canres.2276.2020

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Cell Rep, 2021, 36(2):109343

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J Cell Sci, 2021, 134(1)jcs251025

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Open Biol, 2021, 11(9):210161

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Int J Med Sci, 2021, 18(15):3516-3525

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Breast Cancer, 2021, 10.1007/s12282-021-01242-z

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Elife, 2021, 10e62640

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Commun Biol, 2021, 4(1):358

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STAR Protoc, 2021, 2(1):100293

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EMBO Rep, 2021, e51030

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Biomedicines, 2021, 9(5)579

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Mol Cell, 2020, S1097-2765(20)30774-7

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Cancers (Basel), 2020, 12(9)E2498

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Cells, 2020, 9(9)E2126

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ACS Chem Biol, 2020, 20;15(3):669-674

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J Cell Sci, 2020, 2;jcs.244442

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Biochem Biophys Res Commun, 2020, 521(4):833-839

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DNA Cell Biol, 2020, 10.1089/dna.2019.5002

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Front Vet Sci, 2020, 7:611270

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Sci Rep, 2020, 10(1):12327

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Cells, 2020, 9(1)

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J Cancer, 2020, 11(11):3274-3287

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Neuroreport, 2020, 31(11):787-797

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Cancers (Basel), 2020, 12(7):1824

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Cell Res, 2019, 29(7):562-578

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Mol Cell, 2019, 73(5):915-929

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Nat Commun, 2019, 10(1):3779

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Nat Commun, 2019, 10(1):993

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Sci Adv, 2019, 5(8):eaav0318

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Cell Syst, 2019, 8(2):163-167

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J Cell Biol, 2019, 218(4):1250-1264

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EBioMedicine, 2019, 41:244-255

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Cell Death Dis, 2019, 10(6):385

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Ther Adv Med Oncol, 2019, 11:1758835919846375

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J Mol Cell Biol, 2019, 10.1093/jmcb/mjz051

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Mol Cancer Ther, 2019, 18(9):1615-1627

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Mol Cancer Res, 2019, doi: 10

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Lab Invest, 2019, 99(9):1275-1286

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Sci Rep, 2019,

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Cell Div, 2019, 14:4

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J Biol Chem, 2019, 294(22):8760-8772

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Front Genet, 2019, 10:411

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Open Biol, 2019, 9(8):190136

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Mol Reprod Dev, 2019, 86(8):972-983

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Planta Med, 2019, 85(3):217-224

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Elife, 2019, 8e47097

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Mol Cell, 2018, 71(1):117-128

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EMBO Mol Med, 2018, 10(9)

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Theranostics, 2018, 8(10):2884-2895

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Cancer Res, 2018, 78(2):572-583

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Cell Rep, 2018, 25(13):3618-3630.e6

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Elife, 2018, 7:e36739

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Sci Signal, 2018, 11(549)

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Pigment Cell Melanoma Res, 2018, 31(2):253-266

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Mol Cell Proteomics, 2018, 17(12):2434-2447

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J Cell Mol Med, 2018, 22(11):5300-5310

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Hum Gene Ther, 2018, 29(8):886-901

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Cell Signal, 2018, 52:137-146

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Cancer Med, 2018, 7(11):5589-5603

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Transl Oncol, 2018, 11(4):852-863

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PLoS One, 2018, 13(5):e0197165

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Nucleic Acids Res, 2018, 46(20):10724-10739

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Cell Res, 2017, 27(2):274-293

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Nat Commun, 2017, 8(1):1506

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Aging Cell, 2017, 16(3):575-584

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Elife, 2017, 6

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Elife, 2017, 6e30523

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FASEB J, 2017, 32(2):625-638

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Cell Physiol Biochem, 2017, 43(2):431-444

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Sci Rep, 2017,

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Biochem Biophys Res Commun, 2017, 484(4):864-870

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Oncotarget, 2017, 9(13):10920-10933

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Nat Chem Biol, 2016, 10.1038/nchembio.2017

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Cell Cycle, 2016, 15(15):2009-18

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PLoS One, 2016, 11(4):e0153818

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Oncotarget, 2016, 7(18):26580-92

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Head Neck, 2016, 10.1002/hed.24349

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Oncotarget, 2016, 7(31):50215-50228

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Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(1):31-43

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Cell Cycle, 2015, 14(7):1070-81

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Oncotarget, 2015, 6(4):2315-30

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Oncotarget, 2015, 6(4):2315-30

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Nat Cell Biol, 2014, 16(6):538-49

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Clin Cancer Res, 2014, 20(12):3211-21

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Cancer Res, 2014, 74(20):5878-90

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J Biol Chem, 2014, 289(20):14066-74

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Biosci Rep, 2014, 34(3)

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PLoS One, 2014, 9(10):e111146

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The University of Queensland, 2014, Fawzi Faisal A. Bokhari

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Dev Cell, 2013, 25(6):555-71

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Proc Natl Acad Sci USA, 2013, 110(32):13026-31

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Cancer Res, 2013, 73(22):6722-33

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Cell Rep, 2013, 4(4):803-16

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Oncogene, 2013, 10.1038/onc.2013.518

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Br J Cancer, 2013, 110(2):510-9

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Gynecol Oncol, 2013, 128(3):461-9

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Invest Ophthalmol Vis Sci, 2013, 54(13):8353-63

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Cancer Biol Ther, 2013, 14(5):436-49

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Cell Cycle, 2013, 12(14):2255-65

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PLoS One, 2013, 8(10):e77390

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J Biomol Screen, 2013, 18(1):54-66

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Biol Open, 2013, 2(5):479-86

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Cancer Res, 2013, 73(22):6667-78

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J Cell Sci, 2012, 125(Pt 21):5061-72

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J Biol Chem, 2012, 287(6):4376-85

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J Biol Chem, 2012, 287(21):17088-99

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Cell Cycle, 2012, 11(3):543-53

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PLoS One, 2012, 7(10):e46546

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Nat Cell Biol, 2011, 13(10):1265-71

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Cancer Res, 2011, 71(4):1385-95

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Cancer Res, 2011, 71(17):5659-69

PubMed: 21693658 ( click the link to review the publication )

J Cell Biol, 2011, 193(6):1083-99

PubMed: 21646404 ( click the link to review the publication )

Oncogene, 2011, 30(46):4666-77

PubMed: 21602893 ( click the link to review the publication )

J Invest Dermatol, 2011, 131(9):1886-95

PubMed: 21654832 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description

Features

The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

Targets

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. ^[1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	M1HMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MofqTWM2OD1yLkCwO\|c3KM7:TR?=	NW\VbpBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ACN	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkTtTWM2OD1yLkCwPFQ{KM7:TR?=	NVvkTmc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-8	M2r4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NU\3TWZTUUN3ME2wMlAxQTRzIN88US=>	NY[zV4lNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LC-2-ad	NXOzPIZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NU\lNmx1UUN3ME2wMlAyODl\|IN88US=>	NH3xSpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ALL-PO	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{f5UmlEPTB;MD6wNVMh\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EW-16	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnfoTWM2OD1yLkCxN\|M3KM7:TR?=	NGrPWos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KM12	M2jtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXrYd203UUN3ME2wMlAyOzR6IN88US=>	NHnaSFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GI-1	M3;mWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1\ydmlEPTB;MD6wNVM5OyEQvF2=	NInydZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-411N	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRTBwMEG0NFch\|ryP	M3zldlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ES8	Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3\FRWlEPTB;MD6wNVQ6PCEQvF2=	NEHtUGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C2B	NYnKd4k6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIHtOGVKSzVyPUCuNFE2OjZizszN	MoqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CESS	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXzJR\|UxRTBwMEG2NFIh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
697	NGrrWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2i5WGlEPTB;MD6wNVY3QCEQvF2=	NFO3W3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1963	MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXS2eGlXUUN3ME2wMlAyPjd\|IN88US=>	NH3nOpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
IA-LM	M4foeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFPsd\|RKSzVyPUCuNFE3QDhizszN	M1vNelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SW954	NU\NNnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEHoN45KSzVyPUCuNFE4ODVizszN	NFzte\|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RL95-2	M4XYXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXTJR\|UxRTBwMEG3N\|gh\|ryP	MkDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LXF-289	NV;zTGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXzBVoNWUUN3ME2wMlAyPzdizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
OCUB-M	NGX2dZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2nBdmlEPTB;MD6wNVgzPiEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RKO	M3nPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3fpPGlEPTB;MD6wNVk5PyEQvF2=	NFr3[IY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LOUCY	NH\jdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1PtOWlEPTB;MD6wNlA2KM7:TR?=	M1TxXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NOS-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mk\CTWM2OD1yLkCyNFk{KM7:TR?=	Mmm4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
A4-Fuk	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTBwMEKyNVgh\|ryP	NUW4[oV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
A388	MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkjxTWM2OD1yLkCyNlI4KM7:TR?=	NVe1RW1pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-9	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlvnTWM2OD1yLkCyNlYyKM7:TR?=	M{XSVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KURAMOCHI	M1zwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2n2XmlEPTB;MD6wNlI5PSEQvF2=	NFjBOpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KALS-1	NGLJfHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTBwMEKzN\|gh\|ryP	NXrGTZYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HOP-62	NHSzOG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2TIZmlEPTB;MD6wNlQzKM7:TR?=	MkGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RPMI-8402	M1fSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2nRb2lEPTB;MD6wNlUxQCEQvF2=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHPqSnZKSzVyPUCuNFI2OTJizszN	NY\nd\|BvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CCRF-CEM	MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnv1TWM2OD1yLkCyOVQ{KM7:TR?=	NHy3cVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HUTU-80	NFziUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVLWS2xiUUN3ME2wMlAzPjJ2IN88US=>	NF\5SmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1648	NGrmUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{PZOmlEPTB;MD6wNlY1PyEQvF2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HCE-4	M4PGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHnEU3dKSzVyPUCuNFI3QDJizszN	NVLkboNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ETK-1	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVnxXXNGUUN3ME2wMlAzPzN4IN88US=>	NWDjRZFORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-15	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmDaTWM2OD1yLkCyO\|M5KM7:TR?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BE-13	NUnwOHlQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHrqfXZKSzVyPUCuNFI4PCEQvF2=	NF3Y[mo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KE-37	NUHPXWxzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGXQbm5KSzVyPUCuNFI4PDFizszN	MlKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1355	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVHSPXhxUUN3ME2wMlAzPzh\|IN88US=>	M3Pt[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-11	NFjlXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml\VTWM2OD1yLkCyPFA6KM7:TR?=	NILZXlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
BL-70	NWmxZmdLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4\NfWlEPTB;MD6wNlg2PyEQvF2=	NI\jVZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES6	NXv1[G1WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXnJR\|UxRTBwMEK4PFEh\|ryP	NUnONnlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
GT3TKB	NVu5NYhLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1nwSGlEPTB;MD6wNlk2OyEQvF2=	NHTSToo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LB647-SCLC	MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVXJR\|UxRTBwMEOxPVUh\|ryP	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB13	NHTp[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmflTWM2OD1yLkCzN\|E3KM7:TR?=	M1TEclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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NCI-H1882	M2rvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rkPGlEPTB;MD6wPVgxQSEQvF2=	NWrlRlZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
BB65-RCC	M1PWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NULEbGhSUUN3ME2wMlExOjl2IN88US=>	NHPyVGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
DU-4475	Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYTzeoNXUUN3ME2wMlExPDB5IN88US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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NEC8	Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mki4TWM2OD1yLkGwOVI2KM7:TR?=	M2PuOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H1304	MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWXTUFlyUUN3ME2wMlExPTl2IN88US=>	NX3lbYtORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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SF539	M2XOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4ftNmlEPTB;MD60PFY5PCEQvF2=	M13qclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LB2518-MEL	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV7rTGJoUUN3ME2wMlQ6PzB\|IN88US=>	NYDwellnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-441-T	MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVfNdFJlUUN3ME2wMlUxOTJizszN	M36wWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MDA-MB-134-VI	M2i2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEWyVFJKSzVyPUCuOVA6OjFizszN	M{TjOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SCC-3	M1\EfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFXBfotKSzVyPUCuOVE5PzNizszN	NYnSV3VXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KLE	MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTBwNUKxO\|Eh\|ryP	MmHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	NIDEWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTBwNUK1NlUh\|ryP	MmLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1417	M3;1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTBwNUO0N\|Uh\|ryP	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2081	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUTWOYZnUUN3ME2wMlU5PjFzIN88US=>	NHPob4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1522	NFfzb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYHMSnFlUUN3ME2wMlU6Ozh\|IN88US=>	M3fXRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H889	MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHzpTnpKSzVyPUCuOVk5PDRizszN	Mm\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CGTH-W-1	MkLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXfWZ\|dEUUN3ME2wMlYxPzV3IN88US=>	M3TSdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EB-3	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWX1WWtZUUN3ME2wMlYyOTV\|IN88US=>	MonsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
D-336MG	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX\lfo1FUUN3ME2wMlYyPzlzIN88US=>	M4fve\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LC-1F	NVfLc\|B5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTBwNkK1PVIh\|ryP	NELqb2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MHH-NB-11	MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH\JZZlKSzVyPUCuOlM5ODFizszN	NYTwcZhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SK-N-FI	M{Xrb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4rMemlEPTB;MD62N\|kyKM7:TR?=	M{D5U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H69	M4\HN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1TPZWlEPTB;MD62OFg4QSEQvF2=	NFPGdJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SCH	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFTIZnJKSzVyPUCuOlYxOjNizszN	NVXwT2dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LS-513	NITqNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mnz4TWM2OD1yLk[3NlU6KM7:TR?=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CP67-MEL	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M37idWlEPTB;MD62O\|U6PiEQvF2=	NH:2Z2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GCIY	NITrT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2rofGlEPTB;MD63NFM3OyEQvF2=	M3y1flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SHP-77	NYLKc41wT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjzNXdKSzVyPUCuO\|A4OzRizszN	MkXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EHEB	MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml65TWM2OD1yLkexPFU1KM7:TR?=	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
D-247MG	MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmjLTWM2OD1yLkezNlMzKM7:TR?=	NUfLNIhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
Raji	Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLre4lKSzVyPUCuO\|Q6QDlizszN	M3vOWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MPP-89	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnfXTWM2OD1yLke1PVc5KM7:TR?=	M3zJRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EKVX	NYLSSVZXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWLJR\|UxRTBwN{mwO\|Mh\|ryP	M4fvelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC2218	M3TieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYmzN\|VnUUN3ME2wMlc6OTNzIN88US=>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KNS-81-FD	NX7EeFhtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUnJR\|UxRTBwOEGwNVEh\|ryP	MofPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HCC2157	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfaSpRKSzVyPUCuPFQ6PTFizszN	NHfTSnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
BT-474	MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYPnO5V6UUN3ME2wMlg5QDV2IN88US=>	M1HzdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H748	NUHCTYFJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoTOTWM2OD1yLkmxNkDPxE1?	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EW-24	MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGHIR45KSzVyPUCuPVIxODJizszN	NXTESI5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-263MG	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGe0ZXlKSzVyPUCuPVQ2OTJizszN	MlrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
OMC-1	MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWHoUnVwUUN3ME2wMlk3Ozd\|IN88US=>	MmXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2196	MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mny2TWM2OD1yLkm3O\|c4KM7:TR?=	M{n2RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HAL-01	NGfKSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHLLUHpKSzVyPUCuPVk5PzJizszN	M33rblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H2107	NVfxXG1kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1f6R2lEPTB;MT6wNVg2PCEQvF2=	MnLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LB996-RCC	NVridmxxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV;leYo5UUN3ME2xMlA5ODVzIN88US=>	NGL5N3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1395	NFHn[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfYd5Z[UUN3ME2xMlExPjdizszN	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CHP-126	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV\EVHFuUUN3ME2xMlE3OTl7IN88US=>	MlfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB69	MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnJR\|UxRTFwMk[xOFgh\|ryP	M2DD[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CAS-1	NF7GZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFPifZRKSzVyPUGuN\|QzOzFizszN	M3zrd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
JVM-3	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkjJTWM2OD1zLkS3PFU2KM7:TR?=	NWLPVJVERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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NCI-H1650	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXXzNFU2UUN3ME2xOk4{PzZ3IN88US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
Mo-T	NHrnbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHMeoVnUUN3ME2xO{41ODJ7IN88US=>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB7	MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnfjTWM2OD1zNz63OFY4KM7:TR?=	NHntOY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES7	M4jtV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1P5[2lEPTB;MUmuOVUxPyEQvF2=	Mn\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES5	NWnrTI9NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGjTSGVKSzVyPUKxMlc3PzFizszN	MnXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MSTO-211H	MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUPnVlI4UUN3ME2yNU45QDV6IN88US=>	MnjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
U-87-MG	MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVe4emd7UUN3ME2yOU4yQTZ4IN88US=>	MnjEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
THP-1	M3rj[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2PZS2lEPTB;MkmuO\|IxOSEQvF2=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB10	M1vzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHyzepFKSzVyPUOwMlI3QTRizszN	MkHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NH-12	NUflV49tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3XQemlEPTB;M{OuNlAyPyEQvF2=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-824	MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Moj5TWM2OD1\|ND6xNFA3KM7:TR?=	MoiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SKM-1	MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYXJR\|UxRTN5Lki0NlIh\|ryP	M2m1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H1838	NVjyOWF[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXHJR\|UxRTN6LkO3PVch\|ryP	NWHneotkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RL	NWLTXmFCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHq3eIxKSzVyPUO5MlI1PzdizszN	NXLxZlk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
COLO-800	NHHVelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTRyLkC3O\|Mh\|ryP	NX;vRnRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KG-1	Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF7OToNKSzVyPUSwMlg6PTVizszN	NY\FdoNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TUR	MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoDTTWM2OD12MT62N\|k6KM7:TR?=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC	NI\RfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF7uN5ZKSzVyPUSxMlkxOTdizszN	M4i0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H322M	NWLDNJZTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUXRWmhDUUN3ME20Nk42QTh2IN88US=>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP	NFnzWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHPyNoRKSzVyPUmxMlMhdk1?	MmHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MEWxO\|QoRjJ3NUC1NVc1RC:jPh?=
C4-2	NXTSUZdpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDHTWM2OD16IH7N	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyNUG3OEc,OjV3MEWxO\|Q9N2F-
JURKAT	M2KyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MUCyOEBp		NVnxVJpCUUN3ME20NVYvPjZibl2=	M3HFPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
MOLT-4	NVXRVFMzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHnafVczPCCq		NYDIbJJsUUN3ME2yPFU{NjVibl2=	NEXE[mg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
REH	MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MViyOEBp		MlvvTWM2OD1{OEeuOlghdk1?	NEDQUFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-6	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3ToOlI1KGh?		NXLP[lhFUUN3ME2zOFM{OCCwTR?=	NUC2TY5LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
RS 4;11	NFnPN\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NF[3bJIzPCCq		NHjaT4NKSzVyPUWxPU4xPSCwTR?=	M4nkO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	NX6yelA{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1LFNVI1KGh?		MkXGTWM2OD1{MUC3MlEhdk1?	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	NFXuWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnPzNlQhcA>?		MoLJTWM2OD1zOUmuO\|chdk1?	M{O4d\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MUKyOEBp		MUHJR\|UxRTV{LkG4JI5O	M{\jXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	M2exNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NWnTTXA5OjRiaB?=		MmHXTWM2OD1\|OT6yO{BvVQ>?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	M2DCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1PZeVI1KGh?		NWXSWGZ2UUN3ME25Ok4zQCCwTR?=	NILKNXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
JURKAT	MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NITMZWI1QCCq		NYrzeFY{UUN3ME2xOE45PCCwTR?=	MkXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	M2jKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NILPV5c1QCCq		MljLTWM2OD1{Nj62JI5O	M1jYXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
REH	NWrGTFE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3KwU\|Q5KGh?		NUKyRlV2UUN3ME20OE44OSCwTR?=	NGH0c5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-6	MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mlv5OFghcA>?		NG\ZUHZKSzVyPUKzMlI3KG6P	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
RS 4;11	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXG0PEBp		MX\JR\|UxRTF4ND6yPEBvVQ>?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
697	NVLC[5RrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NIX5SZc1QCCq		MV3JR\|UxRTNyNT6zJI5O	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4K5elQ5KGh?		NVLHN4F7UUN3ME23OE43OiCwTR?=	NX\4WnFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
CEM	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXXX[mw{PDhiaB?=		M2ThRmlEPTB;MkSuOVUhdk1?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
P12	NEDwWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnmyOFghcA>?		NYTBcY9OUUN3ME2xPE41PiCwTR?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M4\I[FQ5KGh?		MVPJR\|UxRTZ\|LkK0JI5O	MmrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
JURKAT	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1fneFczKGh?		NUfiVVFPUUN3ME2zMlY2KG6P	NHPXTWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
MOLT-4	M13PfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUP3[Gg6PzJiaB?=		M4HPOGlEPTB;Nz6zPUBvVQ>?	MkiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
REH	NUjHW286T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NX7pe2p5PzJiaB?=		MYnJR\|UxRTF4LkCxJI5O	NYPOOZdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-6	MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3zOcFczKGh?		NESyfZpKSzVyPUGuO\|ghdk1?	NXnUfIZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
RS 4;11	NYjxNW1RT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHTkU2g4OiCq		NVOyblBRUUN3ME20MlM5KG6P	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
697	MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYrzcZVOPzJiaB?=		NFrXbYxKSzVyPUe0MlI5KG6P	NHH5TII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
SIL-ALL	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUT3OJdwPzJiaB?=		NFzPSZBKSzVyPUeuNkBvVQ>?	NV3WcFRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
CEM	M2Th[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MWW3NkBp		M2jsXWlEPTB;NT60NkBvVQ>?	NXu1PHhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
P12	M4nyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NFHiSHU4OiCq		MlPWTWM2OD14LkO3JI5O	M4fDSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
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WER-Rb-1	MYjBdI9xfG:\|aYOgRZN{[Xl?	NWHJRnN5OS13MDDuUS=>	NID1ZpYyOi9{NDDo	NWDheIdKTE2VTx?=	MkDubY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	Mln5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nk[2OlUoRjJ2M{[2OlY2RC:jPh?=
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CB660	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWXidFN{UUN3ME22MlQhdk1?	NILjVHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB1117	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRTF3Lk[gcm0>	MoK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
KB-3-1	MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2PSZ2lEPTB;MT60PEDDuSByLkWzJI5O	MoHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-8-5-11	NX21eFdNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXzJR\|UxRTVwMEGgxtEhOi5yMTDuUS=>	Ml7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-C-1	NVrybIhkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnTETWM2OD1zNj63OkDDuSB2LkWxJI5O	NIrNcow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
KB-V-1	Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3ROpFKSzVyPUK4NU4zPCEEsTCzNU42PyCwTR?=	M1X3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
OVCAR-8	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NITwNHFKSzVyPUeuNVkhyrFiMz62NEBvVQ>?	NIDOdXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
NCI-ADR-RES	NX71WZc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHnae4lKSzVyPUGyO\|MvOzBiwsGgNVkyNjJyIH7N	NVvmdGo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MCF7	NYDIcIZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX7Bd21TUUN3ME21MlEyKMLzIEGuOFchdk1?	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MCF7-FLV1000	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnvITWM2OD1\|OUOuNVghyrFiN{SuPFMhdk1?	NVPMV2VsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
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CORL-23/P	M{HrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{e3cmlEPTB;ND6zPEDDuSBzLkK1JI5O	MonYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
CORL-23/R	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnL3TWM2OD13LkG2JOKyKDFwOEOgcm0>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
NIH3T3	NWK3SXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVvHN5NTUUN3ME20NE43OCEEsTC0Mlk4KG6P	NVOzZ\|JTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
NIH3T3-G185	M36xN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NY\4To91UUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=>	M4fDR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
pcDNA-HEK293	M4\1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXHJR\|UxRTJwN{WgxtEhOC54NzDuUS=>	MnfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MDR19-HEK293	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml;BTWM2OD16NT61NEDDuSBzMz62O{BvVQ>?	M4jU[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
R482-HEK293	NWPHNZZqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjIUVdKSzVyPUK1Mlk4KMLzIESuPVUhdk1?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MRP1-HEK293	MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MljtTWM2OD1{Lkm5JOKyKDFwNEmgcm0>	M2\BXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
SF188	NUHlcJVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIHvN\|UyOC1zMECgcm0>	M2DEWVI1NTl4IHi=	MljySG1UVw>?	M2S3NYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGOxbnPlcpRz[XSrb36tJIRmeGWmZX70JI1idm6nch?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6N{[0OUc,OjN6OEe2OFU9N2F-
T98G	M2XGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4DPR\|ExNTFyMDDuUS=>	MnPvNlQuQTZiaB?=	MYLEUXNQ	NFv4N4tqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDjc45k\W62cnH0bY9vNSCmZYDl[IVvfCCvYX7u[ZI>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6N{[0OUc,OjN6OEe2OFU9N2F-
DU145	Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGHkS\|ZFVVOR	NXrEfJBrUUN3MPMIwFYxKG6P	M{nUSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEi0OFI5Lz5{M{i4OFQzQDxxYU6=
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RT4	MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzFSFJxUUN3ME2yO{4zOSCwTR?=	NY\EXG5IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVI3OzlpPkKzO\|kzPjN7PD;hQi=>
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MCF7	MlzvSpVv[3Srb36gRZN{[Xl?	MV6xNFAhdk1?	NXvtNZlEOSCq	MWTEUXNQ	MmnMdoVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb\|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>?	NUXGUlF[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O\|AzPDRpPkKzO\|cxOjR2PD;hQi=>
KB-V1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTNwOUKg{txO	NYXCUVVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVMyQTZpPkKzOVk{OTl4PD;hQi=>
Hec50co	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGnSVY9KSzVyPUWgcm0>	NFnSUo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0OlY5Pyd-MkOxOFY3QDd:L3G+
MDA-MB-468	NF3heWZCeG:ydH;zbZMhSXO\|YYm=	MX2xM\|UwOTBibl2=	NGHCRZIzPC92OD:3NkBp	M4C2R2ROW09?	MnKxbY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2NEK5OEc,OjNzNESyPVQ9N2F-
MCF10A	M{m1ZmFxd3C2b4Ppd{BCe3OjeR?=	MnLCNU82NzFyIH7N	M2DxXVI1NzR6L{eyJIg>	NUTGOllqTE2VTx?=	NUf1Rm9McW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	Mnz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
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Daoy	NG\HXVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYXkfpVuOS56N{WtNlQxKG6P	M4LTTlczKGh?	NXzEbllVTE2VTx?=	MmPBTWM2OD13IH7N	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN7MEK3PUc,OjJ\|OUCyO\|k9N2F-
ONS-76	NYXUV5NYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\wOllZOS56N{WtNlQxKG6P	Mln1O\|IhcA>?	NEPRPXpFVVOR	NGHteFlKSzVyPUeuOUBvVQ>?	NHTOV5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO5NFI4QSd-MkKzPVAzPzl:L3G+
SUM 149	MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWSwMVExOCCwTR?=	Mlz4O\|IhcA>?		MXHpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	MoLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|MEm5N\|koRjJ{M{C5PVM6RC:jPh?=
MDA-MB-231	M4fMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NILYRpUxNTFyMDDuUS=>	MlfnO\|IhcA>?		NGX3[XhqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI>	MkPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|MEm5N\|koRjJ{M{C5PVM6RC:jPh?=
HR5	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3[xNVAuOTByIH7N	M4TzZlczKGh?		MXzpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
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BT-12	NYTacGdveUiWUzDhd5NigQ>?				MYHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDCWE0yOiClZXzsdy=>	M{T6PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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Fibroblast cells	MkXUdWhVWyCjc4PhfS=>				MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG\|dDDj[Yxtew>?	MlfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
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A673	MmLYdWhVWyCjc4PhfS=>				NUTVS4RkeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSTZ5MzDj[Yxteyl?	M3zENVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37	NFLHdVByUFSVIHHzd4F6				NFi0NHZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1\|NzDj[Yxtew>?	MlzVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
MG 63(6-TG R)	MlLodWhVWyCjc4PhfS=>				NFTMNHRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBOTyB4MzCoOk1VTyCUKTDj[Yxtew>?	NVnGTWhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Fibroblast cells	MmLvdWhVWyCjc4PhfS=>				MnS2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgZ49vfHKxbDDIbEB4cWymIIT5dIUh\mmkcn;icIF{fCClZXzsdy=>	M4PJfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50	Mk\1dWhVWyCjc4PhfS=>				M1rHbZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>?	M2r1dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD	NYfEV5BJeUiWUzDhd5NigQ>?				M3H3O5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJFKGOnbHzz	NInlRXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SJ-GBM2	MnnOdWhVWyCjc4PhfS=>				M3fObpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSj3HRm0zKGOnbHzz	MkD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC	MYDxTHRUKGG\|c3H5				NED4OolyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	M2DIW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	MnPKdWhVWyCjc4PhfS=>				NInrOHhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=>	NHTmcXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
LAN-5	MkCzdWhVWyCjc4PhfS=>				M4HhZpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	M{HwV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	NYXKPI04eUiWUzDhd5NigQ>?				NG[wTY9yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB1643	NX3TdXhUeUiWUzDhd5NigQ>?				NUnDcJVqeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy\|	M{fGPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	MlK0dWhVWyCjc4PhfS=>				NFi0NHdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLV3DJINmdGy\|	M13mSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	MWPxTHRUKGG\|c3H5				NXTrcJJ1eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
TC32	MWTxTHRUKGG\|c3H5				NVvkPIhZeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN\|MjDj[Yxtew>?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	NWT6[Jh4eUiWUzDhd5NigQ>?				MnHldWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=>	M1jaZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Saos-2	MmDZdWhVWyCjc4PhfS=>				NV;JTHp4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy\|	M3LEe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DU145	MojrRZBweHSxc3nzJIF{e2G7	MUGxNFAhdk1?	NWHtcW5vOjRiaILz		M2DIdmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iUFHSVEBkdGWjdnHn[UBifCBzMECgcm0h[W[2ZYKgNlQhcHK\|IHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	M1zEbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
HeLa	NWrMbGdpTnWwY4Tpc44h[XO\|YYm=	MYGxNFAhdk1?			Ml7JTY5pcWKrdHnvckBw\iCSTFuxJHRpejJzMDDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iSHXMZUBk\WyuczDheEAyODBibl2gZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	M2LmO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
DU145	NIj3OGpHfW6ldHnvckBie3OjeR?=	NFLuT5cyODBibl2=			M3zqTGlvcGmkaYTpc44hd2ZiUFzLNUBxem:2ZXnuJIFk[3WvdXzheIlwdiCrbjDoeY1idiCGVUG0OUBk\WyuczDheEAyODBibl2gZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	Mn;4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
HeLa	MV;GeY5kfGmxbjDhd5NigQ>?	NVv3WJZUOTByIH7N			MX7Jcohq[mm2aX;uJI9nKFCOS{GgdJJwfGWrbjDhZ4N2dXWuYYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	M2q2VmZ2dmO2aX;uJIF{e2G7	NUH5[HpUOTByIH7N	M374OlE5KGi{cx?=		MWXJcoR2[3Srb36gc4YhdW:wb4DvcIFzKG2rdH;0bYMhe3CrbnTs[ZMhcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	NUXVS4dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	MYjBdI9xfG:\|aYOgZZN{[Xl?	MmXzNVAxKG6P	M4\YclI1KGi{cx?=		NEDFbG1KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iUFHSVEBkdGWjdnHn[UBifCBzMECgcm0h[W[2ZYKgNlQhcHK\|IHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	M4HMZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
PC3	NHf6VGdHfW6ldHnvckBie3OjeR?=	NWjMS3Z1OTByIH7N	MoTrNVghcHK\|		Mo\rTY5lfWO2aX;uJI9nKG2xbn;wc4xieiCvaYTveIlkKHOyaX7kcIV{KGmwIHj1cYFvKFCFMzDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	NVLKflc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
DU145	NF7PO41HfW6ldHnvckBie3OjeR?=	NGrLO3cyODBibl2=			MXTJcohq[mm2aX;uJI9nKFCOS{GgWIhzOjFyIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCGVUG0OUBk\WyuczDheEAyODBibl2gZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	NWq1d2s4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

In vivo

BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. ^[1]

Protocol

Kinase Assay: ^[1]	- Collapse Plk1 in vitro kinase assay: Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research: ^[1]	- Collapse Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc. Concentrations: Dissolved in DMSO, final concentrations ~1 μM Incubation Time: 24 and 72 hours Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: Female BomTac:NMRI-Foxn1^nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells Dosages: ~50 mg/kg Administration: Injection i.v. once or twice per week (Only for Reference)

References

Solubility (25°C)

In vitro	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	12.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI 2536 SDF

Molecular Weight	521.66
Formula	C₂₈H₃₉N₇O₃
CAS No.	755038-02-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
Answer:
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

Selective Plk Inhibitors

GSK461364 : Plk1-selective, K_i=2.2 nM.
Plk Inhibitor in Clinical Trial

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
Newest Plk Inhibitor

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
Calssic Plk Inhibitor

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

Related PLK Products

Ro-3306 ^New

RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K_i of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.
ML141 ^New

ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.
HMN-214

HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
GSK461364

GSK461364 (GSK461364A) inhibits purified Plk1 with K_i of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3. Phase 1.

Features:Demonstrates >390-fold selectivity for Plk1 relative to Plk2 and Plk3.
Volasertib (BI 6727)

Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.

Features:A high volume of distribution, indicating good tissue penetration, and a long terminal half-life.
Ro3280

RO3280 (Ro5203280) is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Features:A selective PLK1 inhibitor. Demonstrates greater potency than BI2536. Potential use in nasopharyngeal carcinomas.
Onvansertib (NMS-P937)

Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.

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BI 2536