BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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Cited by 91 Publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnPZ3d{UUN3ME2wMlAxPzd4IN88US=> MoLJV2FPT0WU
ACN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7kUGNKSzVyPUCuNFA5PDNizszN MWXTRW5ITVJ?
TE-8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEC5OFEh|ryP M1jJ[XNCVkeHUh?=
LC-2-ad NF\YV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV61T2V2UUN3ME2wMlAyODl|IN88US=> NUfFTZBrW0GQR1XS
ALL-PO M2rxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVyzUXYzUUN3ME2wMlAyOyEQvF2= MYLTRW5ITVJ?
EW-16 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq1TWM2OD1yLkCxN|M3KM7:TR?= MUfTRW5ITVJ?
KM12 M1vGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT1fpJQUUN3ME2wMlAyOzR6IN88US=> MWPTRW5ITVJ?
GI-1 NHKzcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPQTWM2OD1yLkCxN|g{KM7:TR?= MkfjV2FPT0WU
LS-411N MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;GO2lEPTB;MD6wNVQxPyEQvF2= MWfTRW5ITVJ?
ES8 NUC4U25ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTITWM2OD1yLkCxOFk1KM7:TR?= NIXr[ZZUSU6JRWK=
SNU-C2B NHP2VJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHkNZlKSzVyPUCuNFE2OjZizszN MWjTRW5ITVJ?
CESS NXTwZnhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEG2NFIh|ryP NVrWOpRGW0GQR1XS
697 NWTQUmZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jDV2lEPTB;MD6wNVY3QCEQvF2= NUe3enVWW0GQR1XS
NCI-H1963 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj5TWM2OD1yLkCxOlc{KM7:TR?= M2\0OXNCVkeHUh?=
IA-LM M1LoOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rwemlEPTB;MD6wNVY5QCEQvF2= NV70WJZEW0GQR1XS
SW954 NHjv[VhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\BTWM2OD1yLkCxO|A2KM7:TR?= NIjRTohUSU6JRWK=
RL95-2 NXjGTo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHTZplKSzVyPUCuNFE4OzhizszN NFHn[INUSU6JRWK=
LXF-289 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X1VGlEPTB;MD6wNVc4KM7:TR?= MYXTRW5ITVJ?
OCUB-M MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\5TWM2OD1yLkCxPFI3KM7:TR?= M2DD[3NCVkeHUh?=
RKO M4HYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHkTWM2OD1yLkCxPVg4KM7:TR?= NEXoeVlUSU6JRWK=
LOUCY NGr1VHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HM[2lEPTB;MD6wNlA2KM7:TR?= MVHTRW5ITVJ?
NOS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqyTWM2OD1yLkCyNFk{KM7:TR?= NIrJdJZUSU6JRWK=
A4-Fuk MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHUTWM2OD1yLkCyNlE5KM7:TR?= Moq5V2FPT0WU
A388 NXHGOW5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHybZJKSzVyPUCuNFIzOjdizszN NXr2PZBuW0GQR1XS
TE-9 NHvseWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rEVGlEPTB;MD6wNlI3OSEQvF2= MY\TRW5ITVJ?
KURAMOCHI MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;sO2lEPTB;MD6wNlI5PSEQvF2= MXHTRW5ITVJ?
KALS-1 NVrlZ5VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmxTlViUUN3ME2wMlAzOzN6IN88US=> NHLIOlRUSU6JRWK=
HOP-62 NXq0XFdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf6TWM2OD1yLkCyOFIh|ryP NV:4U|ZWW0GQR1XS
RPMI-8402 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEK1NFgh|ryP NHzZ[pZUSU6JRWK=
TE-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHVTWM2OD1yLkCyOVEzKM7:TR?= MYTTRW5ITVJ?
CCRF-CEM NGLOSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SwWGlEPTB;MD6wNlU1OyEQvF2= NYXFflJ5W0GQR1XS
HUTU-80 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\k[lhKSzVyPUCuNFI3OjRizszN M3TQdXNCVkeHUh?=
NCI-H1648 M4nWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPqWHpKSzVyPUCuNFI3PDdizszN MWPTRW5ITVJ?
HCE-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEK2PFIh|ryP M1zneHNCVkeHUh?=
ETK-1 NGnOcm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX5e29GUUN3ME2wMlAzPzN4IN88US=> NFrkO41USU6JRWK=
TE-15 M2XKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEK3N|gh|ryP MYjTRW5ITVJ?
BE-13 M1LWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f0VWlEPTB;MD6wNlc1KM7:TR?= NWXIcJR6W0GQR1XS
KE-37 NVP4TIlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEK3OFEh|ryP MXrTRW5ITVJ?
NCI-H1355 NF\XO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEK3PFMh|ryP NEnQcHBUSU6JRWK=
TE-11 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TUWlEPTB;MD6wNlgxQSEQvF2= M1HueHNCVkeHUh?=
BL-70 NGrubIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHMbnpIUUN3ME2wMlAzQDV5IN88US=> Mnj0V2FPT0WU
ES6 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnLeII3UUN3ME2wMlAzQDhzIN88US=> MYjTRW5ITVJ?
GT3TKB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnXbZhKSzVyPUCuNFI6PTNizszN MoDQV2FPT0WU
LB647-SCLC NWDGSGZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEOxPVUh|ryP NUDsXJRUW0GQR1XS
NB13 M3jaSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfPTWM2OD1yLkCzN|E3KM7:TR?= M4TxW3NCVkeHUh?=
ST486 M{L4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv6dnZKSzVyPUCuNFM{OzdizszN MoLNV2FPT0WU
NCI-H82 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPzTWM2OD1yLkCzN|Q{KM7:TR?= NWK5V45RW0GQR1XS
NTERA-S-cl-D1 NEOzeIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon2TWM2OD1yLkCzN|k6KM7:TR?= MoTKV2FPT0WU
ES4 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX0S4xuUUN3ME2wMlA{PDZ|IN88US=> Mn7OV2FPT0WU
SK-NEP-1 NV:5fodoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv2TWJRUUN3ME2wMlA{PDl7IN88US=> MUnTRW5ITVJ?
Becker NWHvXplsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\GbmlEPTB;MD6wN|U2PSEQvF2= MmPyV2FPT0WU
A101D M161O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEO3OFgh|ryP M2P4[3NCVkeHUh?=
SK-UT-1 NHPC[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HlWmlEPTB;MD6wN|c4PCEQvF2= M4P2bXNCVkeHUh?=
SW982 NIHLRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEO3PUDPxE1? M1;VW3NCVkeHUh?=
TE-10 NH7CRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrqTWM2OD1yLkC0NFQ3KM7:TR?= NG\peWtUSU6JRWK=
OVCAR-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjYTWM2OD1yLkC0NFU6KM7:TR?= MVrTRW5ITVJ?
KP-N-YS M1G4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nST2lEPTB;MD6wOFA5PSEQvF2= M2XwRXNCVkeHUh?=
BL-41 NH35RYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SwZWlEPTB;MD6wOFEzPSEQvF2= NXnm[nJ6W0GQR1XS
MZ1-PC NYTOU4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT1WYZRUUN3ME2wMlA1OTJ5IN88US=> NEDuUFVUSU6JRWK=
PF-382 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMESxPVgh|ryP M3T6e3NCVkeHUh?=
MOLT-13 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTCN|NKSzVyPUCuNFQzOzhizszN NVfSW297W0GQR1XS
HCC1599 NFXsTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13nW2lEPTB;MD6wOFI2QCEQvF2= M3X6e3NCVkeHUh?=
IST-MEL1 M1zJWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jrUGlEPTB;MD6wOFQ1OiEQvF2= MYTTRW5ITVJ?
LU-139 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPxRZZIUUN3ME2wMlA1PDR{IN88US=> M37NOHNCVkeHUh?=
MS-1 M2T1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3TbIxiUUN3ME2wMlA1PzBzIN88US=> M370fHNCVkeHUh?=
MFH-ino NXS3RWczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHwXWVUUUN3ME2wMlA2ODB|IN88US=> M2XKZ3NCVkeHUh?=
IMR-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTiVIxvUUN3ME2wMlA2ODJzIN88US=> NUX1VYM1W0GQR1XS
TE-5 M1TGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;BPZFKSzVyPUCuNFUxPjNizszN NUnLPYp7W0GQR1XS
DJM-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPNTWM2OD1yLkC1NVQzKM7:TR?= MV;TRW5ITVJ?
NB17 M17BbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLZRVd4UUN3ME2wMlA2OjB5IN88US=> NXnKPGYzW0GQR1XS
KARPAS-45 M3XZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEWzOVgh|ryP M4PadXNCVkeHUh?=
TGBC1TKB NWXLWnoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLPV|FKSzVyPUCuNFU1ODVizszN MmnCV2FPT0WU
ML-2 M3nX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOxdpZKSzVyPUCuNFU1OTRizszN MV;TRW5ITVJ?
no-10 NX;iOotDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;O[2lEPTB;MD6wOVQ4PCEQvF2= MXzTRW5ITVJ?
CTV-1 M3fjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEW1NFIh|ryP NIrVdJNUSU6JRWK=
SJSA-1 NEi5NJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{naO2lEPTB;MD6wOVUzKM7:TR?= MUjTRW5ITVJ?
HC-1 M3\wdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\TRWJ4UUN3ME2wMlA2PTl5IN88US=> M4LienNCVkeHUh?=
TE-12 NYjOOo9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\2WVFrUUN3ME2wMlA2PjF|IN88US=> MmXCV2FPT0WU
KY821 NYHE[YlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\idHRUUUN3ME2wMlA2PjN{IN88US=> NI\LWHpUSU6JRWK=
TALL-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrROIVKSzVyPUCuNFU4ODhizszN MX7TRW5ITVJ?
DEL MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH5TWM2OD1yLkC1O|A6KM7:TR?= M4HuVnNCVkeHUh?=
TE-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfMbZVKSzVyPUCuNFU4OjJizszN M2X6b3NCVkeHUh?=
SK-LMS-1 NIS1OoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXw[|hMUUN3ME2wMlA2QDB3IN88US=> Mnr4V2FPT0WU
EW-1 M3HqNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;6b5VKSzVyPUCuNFU5OzdizszN Mn:0V2FPT0WU
8-MG-BA MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;leI9KSzVyPUCuNFU5PTFizszN Ml7mV2FPT0WU
NALM-6 M3y1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEW5O|Mh|ryP MWrTRW5ITVJ?
LB771-HNC M4SxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEW5O|kh|ryP NYDycoVxW0GQR1XS
HT-144 M17M[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;PTWM2OD1yLkC2NVMh|ryP MVnTRW5ITVJ?
KM-H2 M2Trcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\3cWlEPTB;MD6wOlIzOSEQvF2= MkS1V2FPT0WU
SF268 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TJTWlEPTB;MD6wOlI5PiEQvF2= MmXQV2FPT0WU
RS4-11 NHXHSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3flZ2lEPTB;MD6wOlMxPCEQvF2= MkO1V2FPT0WU
MHH-PREB-1 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrRS|hKSzVyPUCuNFY{OTlizszN M4i0XXNCVkeHUh?=
ATN-1 NVXaWGtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[xTWM2OD1yLkC2N|Q2KM7:TR?= NYTIPXlHW0GQR1XS
BB30-HNC Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P0XGlEPTB;MD6wOlQ{PiEQvF2= NFzLV2NUSU6JRWK=
CPC-N Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[1NlQh|ryP MV\TRW5ITVJ?
NB1 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[2NVMh|ryP NH3zVmRUSU6JRWK=
KS-1 NXTu[mJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\nTWM2OD1yLkC2O|Q5KM7:TR?= MljsV2FPT0WU
RXF393 NHzs[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHJZWppUUN3ME2wMlA3PzZ2IN88US=> MmHBV2FPT0WU
IST-SL2 NHi2fINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDlTWM2OD1yLkC3NFA1KM7:TR?= MmGwV2FPT0WU
GI-ME-N MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrRTWM2OD1yLkC3Nlg3KM7:TR?= NFjhfXhUSU6JRWK=
VA-ES-BJ M1nVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEe0O|Uh|ryP MVnTRW5ITVJ?
NCI-H1581 NUG4VlJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXlTWM2OD1yLkC3OFc5KM7:TR?= MkD4V2FPT0WU
U-266 M{XsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPGXG9KSzVyPUCuNFc1QTdizszN M2DQfnNCVkeHUh?=
DMS-114 NX\hbXBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL1OGdoUUN3ME2wMlA4PTJ6IN88US=> MlHpV2FPT0WU
NCI-H187 NU\HS49HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj6TWM2OD1yLkC3O|I3KM7:TR?= M3;2NnNCVkeHUh?=
SW962 M4f6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HnVGlEPTB;MD6wO|g{QSEQvF2= NVznOZFMW0GQR1XS
MONO-MAC-6 NHy4fohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XPSGlEPTB;MD6wO|k5PiEQvF2= NX;HSXNIW0GQR1XS
MOLT-16 NULFV5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLTNYNKSzVyPUCuNFgyOjFizszN NFPJN3FUSU6JRWK=
KNS-42 NH;WT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u0[2lEPTB;MD6wPFE3OSEQvF2= MmrxV2FPT0WU
CMK MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTZ4FEUUN3ME2wMlA5OjJ3IN88US=> MnjXV2FPT0WU
Ramos-2G6-4C10 NETtSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEiyNlUh|ryP M4riZ3NCVkeHUh?=
Daudi NGrmOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1yLkC4NlU3KM7:TR?= NHTmNpdUSU6JRWK=
NCI-H510A MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO3[mxCUUN3ME2wMlA5OzN4IN88US=> MX;TRW5ITVJ?
LB831-BLC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK5d2YyUUN3ME2wMlA5PTZzIN88US=> NUmwUWlXW0GQR1XS
HEL NIOzZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEi2Olgh|ryP NInse2ZUSU6JRWK=
LU-134-A NWPkZpM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXnZng6UUN3ME2wMlA5PzB6IN88US=> MXjTRW5ITVJ?
NCI-H1694 M4XiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXuNGljUUN3ME2wMlA5PzR2IN88US=> M3zrbXNCVkeHUh?=
KGN Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DKW2lEPTB;MD6wPFc2QSEQvF2= MlrOV2FPT0WU
A253 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfROHd2UUN3ME2wMlA5QDJ{IN88US=> MojqV2FPT0WU
DG-75 NF3wVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\WTWM2OD1yLkC4PVIzKM7:TR?= M{jGd3NCVkeHUh?=
MOLT-4 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfjU|U2UUN3ME2wMlA5QTh|IN88US=> NIXr[5ZUSU6JRWK=
NCI-SNU-5 Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\0dlllUUN3ME2wMlA6OjV6IN88US=> MW\TRW5ITVJ?
ONS-76 NHLkfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLNclR1UUN3ME2wMlA6Ojd4IN88US=> NV7hSIV7W0GQR1XS
NCI-H446 NITZR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MontTWM2OD1yLkC5OFYzKM7:TR?= M37xWHNCVkeHUh?=
COR-L279 M1L3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEm1OVYh|ryP M36wW3NCVkeHUh?=
Calu-6 NIDMdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEm1PVgh|ryP MlHtV2FPT0WU
BC-3 M2\2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jz[WlEPTB;MD6wPVY3OiEQvF2= MVzTRW5ITVJ?
NCI-H2126 MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KzfGlEPTB;MD6wPVc6OSEQvF2= M1nUenNCVkeHUh?=
NCI-H1882 NUHJdHZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv6N|BuUUN3ME2wMlA6QDB7IN88US=> NF[0XI1USU6JRWK=
BB65-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHuTWM2OD1yLkGwNlk1KM7:TR?= NWnrOGM2W0GQR1XS
DU-4475 NFvLOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSxTWM2OD1yLkGwOFA4KM7:TR?= Mn7nV2FPT0WU
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NCI-H1304 M37s[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrPSVFKSzVyPUCuNVA2QTRizszN MXrTRW5ITVJ?
L-540 NU\vSnhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfvSI1KSzVyPUCuNVA4ODhizszN NGj5bYNUSU6JRWK=
NCI-SNU-16 NGPC[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHCTWM2OD1yLkGwO|QzKM7:TR?= MnP0V2FPT0WU
HD-MY-Z MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHxTWM2OD1yLkGwPFU3KM7:TR?= M36xOnNCVkeHUh?=
K-562 M4PsfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3jdlZKSzVyPUCuNVA5PThizszN M3LLW3NCVkeHUh?=
JAR M3rJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMUC5NlUh|ryP NVHuRVdPW0GQR1XS
MZ2-MEL NEXRVFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXKXINKSzVyPUCuNVExPSEQvF2= M3jsSXNCVkeHUh?=
L-363 MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfTe4VKSzVyPUCuNVExPzlizszN MmPpV2FPT0WU
BV-173 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPNTWM2OD1yLkGxNlQ{KM7:TR?= MnTOV2FPT0WU
NCI-H524 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjUXnoxUUN3ME2wMlEyOjd2IN88US=> MofnV2FPT0WU
EoL-1-cell MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXjUo1KSzVyPUCuNVE3PzJizszN NIn2WIhUSU6JRWK=
K052 NH3VbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWwe5JxUUN3ME2wMlEyPzF{IN88US=> M4ixZnNCVkeHUh?=
TK10 NYO3ZWJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfNTWM2OD1yLkGxO|I5KM7:TR?= NVrB[5JqW0GQR1XS
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RPMI-8226 NVHRPG44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXxT3FtUUN3ME2wMlEzODV{IN88US=> MoC2V2FPT0WU
MZ7-mel NVnmUHdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvOTWM2OD1yLkGyNlM4KM7:TR?= M2fsVXNCVkeHUh?=
SK-PN-DW MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPzXYxKSzVyPUCuNVIzQDdizszN MnTmV2FPT0WU
SR NED1NYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPoflRFUUN3ME2wMlEzPDRzIN88US=> M3HDVHNCVkeHUh?=
RPMI-6666 NV30bokyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMUK3OFMh|ryP M1LNSnNCVkeHUh?=
no-11 NG\PV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK0SGNKSzVyPUCuNVI5PjlizszN NEPhU4tUSU6JRWK=
EW-3 M3v0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK2TWM2OD1yLkGyPFk{KM7:TR?= MlLXV2FPT0WU
LAMA-84 NWnvRlEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLPTWM2OD1yLkGzNVg4KM7:TR?= MX3TRW5ITVJ?
HT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKyTWM2OD1yLkGzOVc1KM7:TR?= MWnTRW5ITVJ?
KP-N-RT-BM-1 M{PJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMUO2NVIh|ryP MlLhV2FPT0WU
NCI-H747 NHnNN3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV35b3ozUUN3ME2wMlE{PyEQvF2= M33vcnNCVkeHUh?=
NCCIT MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMUO5N|kh|ryP MlGxV2FPT0WU
MLMA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XQ[GlEPTB;MD6xOFE3PyEQvF2= Ml\kV2FPT0WU
LP-1 NELWSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMUSyOEDPxE1? NHnGU3RUSU6JRWK=
CAL-148 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHIfXVwUUN3ME2wMlE1PDh|IN88US=> MX\TRW5ITVJ?
GB-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHwcW5KSzVyPUCuNVQ2OjZizszN MlrvV2FPT0WU
COR-L88 M4LrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMUS4NFIh|ryP NUe0eWR3W0GQR1XS
NKM-1 NFfkO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfZTWM2OD1yLkG0PVA3KM7:TR?= MYLTRW5ITVJ?
NB5 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SwcmlEPTB;MD6xOVQ3OiEQvF2= NED6TmpUSU6JRWK=
SH-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ixeWlEPTB;MD6xOVQ3PiEQvF2= NXnQ[JJtW0GQR1XS
EM-2 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDjV|Q3UUN3ME2wMlE2PDZ5IN88US=> M4PSOnNCVkeHUh?=
TGBC24TKB NYnhbZRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XTZ2lEPTB;MD6xOVY2QSEQvF2= NWDuUJR6W0GQR1XS
SCLC-21H NES4Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfrUnhyUUN3ME2wMlE2PzB{IN88US=> NHLXUmFUSU6JRWK=
COLO-684 M1TqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HxT2lEPTB;MD6xOVczOSEQvF2= NVLxR49YW0GQR1XS
KINGS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUW5NUDPxE1? NEe1ZnRUSU6JRWK=
LS-123 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTvTWM2OD1yLkG1PVE4KM7:TR?= NYnHc|RGW0GQR1XS
MC116 MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULZflFoUUN3ME2wMlE3OTV6IN88US=> NW\pcZgxW0GQR1XS
SU-DHL-1 NH3NZlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMU[yNFYh|ryP M33YSXNCVkeHUh?=
NCI-H64 MmHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMU[zOFch|ryP M4\QWnNCVkeHUh?=
HCE-T M1;sfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XsOmlEPTB;MD6xOlUxPCEQvF2= NVTsS2pUW0GQR1XS
LOXIMVI M33oOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeyTYg6UUN3ME2wMlE3QTR7IN88US=> NUL2[5k6W0GQR1XS
ARH-77 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnITWM2OD1yLkG3N|c6KM7:TR?= M3PqfHNCVkeHUh?=
DOHH-2 NEe4emZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D1e2lEPTB;MD6xO|Y4OiEQvF2= M1\xWHNCVkeHUh?=
COLO-320-HSR NXPtRlFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DqPGlEPTB;MD6xPFE2PCEQvF2= M1nrS3NCVkeHUh?=
NB6 NUfrV29{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TtNWlEPTB;MD6xPFU3PiEQvF2= M1PlRXNCVkeHUh?=
L-428 Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOyTWM2OD1yLkG4PFE{KM7:TR?= NIPNSJRUSU6JRWK=
SNB75 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMUi4NlQh|ryP NFznNGVUSU6JRWK=
NCI-H2141 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXyXFRKSzVyPUCuNVkxOTFizszN NWjOO5ZxW0GQR1XS
KARPAS-299 NUPVTVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK2SVVKSzVyPUCuNVkzPDFizszN MoXWV2FPT0WU
LC4-1 NXTETFFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMUm1NFIh|ryP M3X1fnNCVkeHUh?=
UACC-257 M4WybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7p[HBKSzVyPUCuNVk6PDdizszN MlzaV2FPT0WU
EVSA-T M{TKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnFNnRvUUN3ME2wMlIxOzF{IN88US=> MonsV2FPT0WU
JiyoyeP-2003 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTFUFRXUUN3ME2wMlIxPDd5IN88US=> NXPCUGdqW0GQR1XS
NCI-H720 NXriUFQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LuW2lEPTB;MD6yNFUzPSEQvF2= NEPNfGxUSU6JRWK=
GAK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMkGxPFkh|ryP NEXQOYhUSU6JRWK=
HH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT2W5VKSzVyPUCuNlE1ODVizszN MorZV2FPT0WU
NCI-H1436 NVi5UoZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLGPWdHUUN3ME2wMlIyPDZ2IN88US=> Mki3V2FPT0WU
GR-ST NUPIPW5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHixN2hKSzVyPUCuNlE1QDhizszN NH7JbYJUSU6JRWK=
BC-1 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjXcGlKSzVyPUCuNlI3OTZizszN NGjsTppUSU6JRWK=
SIG-M5 NWDOUVV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\VTWM2OD1yLkKyO|I4KM7:TR?= NFPPOZZUSU6JRWK=
NCI-H345 M2ftbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjDV3NKSzVyPUCuNlM5ODVizszN NUT6dVEyW0GQR1XS
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LB1047-RCC NHPadHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfyeIRKSzVyPUCuNlQ1OSEQvF2= NYfvTZhoW0GQR1XS
CTB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW2V29KSzVyPUCuNlQ1QTNizszN MYfTRW5ITVJ?
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SF126 MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMkWzPFMh|ryP NWfOcIYxW0GQR1XS
KARPAS-422 NHLjUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDOTWM2OD1yLkK1OFM2KM7:TR?= NGnESFhUSU6JRWK=
MEG-01 NGfm[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknvTWM2OD1yLkK1Olc{KM7:TR?= MYrTRW5ITVJ?
NCI-H209 NH;oXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX5fXFZUUN3ME2wMlI3Ozd2IN88US=> NHLBTG1USU6JRWK=
SBC-1 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXETWM2OD1yLkK2OUDPxE1? MX;TRW5ITVJ?
K5 M33JeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjHNJFOUUN3ME2wMlI3QTh2IN88US=> NWW0bJBZW0GQR1XS
QIMR-WIL NV6wOndYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMkexOVUh|ryP M1[1ZXNCVkeHUh?=
NMC-G1 NGjkcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X0UmlEPTB;MD6yPFIyPyEQvF2= Mn;uV2FPT0WU
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SW684 M4\sZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33YNGlEPTB;MD6zNFA1PyEQvF2= NUnxXJd2W0GQR1XS
MV-4-11 NW\zUI0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[ze5FLUUN3ME2wMlMxPzh6IN88US=> NInIXo9USU6JRWK=
LAN-6 NYjzbGxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITqbIxKSzVyPUCuN|E2PzJizszN NITUVYxUSU6JRWK=
RH-1 NVXp[2V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwM{G4O|Eh|ryP MXjTRW5ITVJ?
CP66-MEL NHTOZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXrTWM2OD1yLkOxPFc5KM7:TR?= NXXaZ|NFW0GQR1XS
EC-GI-10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwM{K5PFch|ryP MkD4V2FPT0WU
GDM-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn72TWM2OD1yLkOzNFU6KM7:TR?= MYDTRW5ITVJ?
IST-SL1 NEjvRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[zWJNKSzVyPUCuN|Q6OTRizszN NIHWTJJUSU6JRWK=
KMOE-2 MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwM{WxO|Uh|ryP NGnLZmdUSU6JRWK=
OS-RC-2 M2DRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\wVWpKSzVyPUCuN|U2PDRizszN MWLTRW5ITVJ?
HDLM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwM{e4NVQh|ryP NUf4OpZ5W0GQR1XS
DSH1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXsRVh[UUN3ME2wMlM5PjNzIN88US=> NUXEUIZOW0GQR1XS
LS-1034 M33Fb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwM{i5OVQh|ryP NHXpTFdUSU6JRWK=
LB373-MEL-D MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDpTWM2OD1yLkO5NVk4KM7:TR?= NWHp[Vd4W0GQR1XS
GOTO MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PzV2lEPTB;MD60NlEyQCEQvF2= NXHF[2dbW0GQR1XS
MRK-nu-1 M1nqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfPTodKSzVyPUCuOFIzODVizszN MUjTRW5ITVJ?
SK-MM-2 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC5TWM2OD1yLkSzOFQzKM7:TR?= MV3TRW5ITVJ?
BOKU MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zETGlEPTB;MD60N|c6OiEQvF2= M4DR[nNCVkeHUh?=
NOMO-1 NUD3VHdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwNEO4OkDPxE1? NUn2RlB2W0GQR1XS
J-RT3-T3-5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmyeJVxUUN3ME2wMlQ1QDd6IN88US=> M3joR3NCVkeHUh?=
COLO-668 M1;BTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonwTWM2OD1yLkS1OlY5KM7:TR?= NUjVXpNoW0GQR1XS
SF539 M2rNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3UTWM2OD1yLkS4Olg1KM7:TR?= MnnoV2FPT0WU
LB2518-MEL MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf5TWM2OD1yLkS5O|A{KM7:TR?= NWf4NIp2W0GQR1XS
TE-441-T NIPKTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHObGo2UUN3ME2wMlUxOTJizszN MUDTRW5ITVJ?
MDA-MB-134-VI Mlf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rmOWlEPTB;MD61NFkzOSEQvF2= MXzTRW5ITVJ?
SCC-3 M16weWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnETWM2OD1yLkWxPFc{KM7:TR?= NEnoTmFUSU6JRWK=
KLE Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTH[XI2UUN3ME2wMlUzOTdzIN88US=> MVrTRW5ITVJ?
LB2241-RCC NEH5SW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu2NnNKSzVyPUCuOVI2OjVizszN M4i0OHNCVkeHUh?=
NCI-H1417 M3SwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe5TWM2OD1yLkWzOFM2KM7:TR?= MX7TRW5ITVJ?
NCI-H2081 MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y1T2lEPTB;MD61PFYyOSEQvF2= NGHGTpdUSU6JRWK=
NCI-H1522 NV74dWxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzqTWM2OD1yLkW5N|g{KM7:TR?= NYTs[FZqW0GQR1XS
NCI-H889 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTEVm1KSzVyPUCuOVk5PDRizszN MW\TRW5ITVJ?
CGTH-W-1 NIi4PW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[yUmlEPTB;MD62NFc2PSEQvF2= NEKxWVFUSU6JRWK=
EB-3 MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwNkGxOVMh|ryP NUfLXYlmW0GQR1XS
D-336MG NIfIZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PLPWlEPTB;MD62NVc6OSEQvF2= MlvSV2FPT0WU
LC-1F Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDveoVKSzVyPUCuOlI2QTJizszN NWPp[YdqW0GQR1XS
MHH-NB-11 NGXTfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDLdYxKSzVyPUCuOlM5ODFizszN Ml2zV2FPT0WU
SK-N-FI M3X3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwNkO5NUDPxE1? MWPTRW5ITVJ?
NCI-H69 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjnVYZKSzVyPUCuOlQ5PzlizszN MWTTRW5ITVJ?
SCH Mk\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M162WWlEPTB;MD62OlAzOyEQvF2= NFzRUHZUSU6JRWK=
LS-513 NEXrTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTFOm9sUUN3ME2wMlY4OjV7IN88US=> M2[3[3NCVkeHUh?=
CP67-MEL NHWwUZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj3TWM2OD1yLk[3OVk3KM7:TR?= Mo[2V2FPT0WU
GCIY NHjye3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnzR3ZPUUN3ME2wMlcxOzZ|IN88US=> M4mxTHNCVkeHUh?=
SHP-77 MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwN{C3N|Qh|ryP NW\2WGF{W0GQR1XS
EHEB M1rCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PURmlEPTB;MD63NVg2PCEQvF2= MVTTRW5ITVJ?
D-247MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofyTWM2OD1yLkezNlMzKM7:TR?= M3LINXNCVkeHUh?=
Raji NWjBU45{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTUcnZKSzVyPUCuO|Q6QDlizszN NYrE[Fh4W0GQR1XS
MPP-89 NIf4ephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jFU2lEPTB;MD63OVk4QCEQvF2= MX;TRW5ITVJ?
EKVX MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHDTWM2OD1yLke5NFc{KM7:TR?= MW\TRW5ITVJ?
HCC2218 M37wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwN{mxN|Eh|ryP NF;RSG5USU6JRWK=
KNS-81-FD NV7tZngzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwOEGwNVEh|ryP NYPzV|ViW0GQR1XS
HCC2157 NFnnN4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPteIRKSzVyPUCuPFQ6PTFizszN M4L3OXNCVkeHUh?=
BT-474 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHTTWM2OD1yLki4PFU1KM7:TR?= Mk[xV2FPT0WU
NCI-H748 NV6zc4VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TL[mlEPTB;MD65NVIh|ryP M2PWWHNCVkeHUh?=
EW-24 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WxTmlEPTB;MD65NlAxOiEQvF2= MUjTRW5ITVJ?
D-263MG NXPId|hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\uTWM2OD1yLkm0OVEzKM7:TR?= M3G0bHNCVkeHUh?=
OMC-1 NXjDTnJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\FOoJKSzVyPUCuPVY{PzNizszN NVf1VphZW0GQR1XS
NCI-H2196 M2DwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITVXGNKSzVyPUCuPVc4PzdizszN MXnTRW5ITVJ?
HAL-01 NGfobnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfVXpAyUUN3ME2wMlk6QDd{IN88US=> NYKxTIdHW0GQR1XS
NCI-H2107 NH7XeXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHUUWNIUUN3ME2xMlAyQDV2IN88US=> M{DmenNCVkeHUh?=
LB996-RCC NU[5W4dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEiyd5NKSzVyPUGuNFgxPTFizszN NYPtS2VHW0GQR1XS
NCI-H1395 NGTTOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3WTWM2OD1zLkGwOlch|ryP MXHTRW5ITVJ?
CHP-126 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFwMU[xPVkh|ryP MVXTRW5ITVJ?
NB69 NUTqRYpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwMk[xOFgh|ryP NUnFVYx3W0GQR1XS
CAS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjyWG1KSzVyPUGuN|QzOzFizszN NWPVT49tW0GQR1XS
JVM-3 MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnRSYxKSzVyPUGuOFc5PTVizszN NXr0TVFsW0GQR1XS
DMS-153 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjrTJVtUUN3ME2xMlU4Pjd2IN88US=> NXnLbGVyW0GQR1XS
SK-MEL-2 NGfxXHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXZSXZ4UUN3ME2xMlcyPzh7IN88US=> MX7TRW5ITVJ?
NCI-H1155 M3LBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLZOXVKSzVyPUGuO|M3PzZizszN MkfNV2FPT0WU
NCI-H1092 NGLjOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nmN2lEPTB;MT63OlE5OiEQvF2= MXTTRW5ITVJ?
LU-165 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwOE[0O|Yh|ryP NYLjUHVrW0GQR1XS
HL-60 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwOUm5NFgh|ryP Mlv4V2FPT0WU
REH NXrHeGF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLkTWM2OD1{LkCwOVgzKM7:TR?= Mln6V2FPT0WU
JVM-2 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnWb3d7UUN3ME2yMlA3OTN3IN88US=> MnfiV2FPT0WU
MN-60 NEHN[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj2eI9KSzVyPUKuNVc{ODhizszN Mmf0V2FPT0WU
SCC-15 M2nhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwMkCyO{DPxE1? M33vUHNCVkeHUh?=
SNU-C1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXBb4VKSzVyPUKuNlE{PDNizszN NXPLTWVnW0GQR1XS
SK-MEL-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfWRmdKSzVyPUKuN|IxPDdizszN MUHTRW5ITVJ?
TGW MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJwM{WwNlch|ryP MlrOV2FPT0WU
CA46 M4fubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\VTWM2OD1{Lke1PVY4KM7:TR?= MU\TRW5ITVJ?
NCI-H23 M{XvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;INGlEPTB;Mj64NFc6OSEQvF2= NGj4cW9USU6JRWK=
MMAC-SF MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwOE[2Nlgh|ryP MWHTRW5ITVJ?
NCI-H2171 M165T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwMEO0OFgh|ryP MYHTRW5ITVJ?
A704 NE\rOZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX62Zpl4UUN3ME2zMlE1OTl2IN88US=> MkftV2FPT0WU
DB NI\uUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfZTWM2OD1|LkK1OVc3KM7:TR?= NHTNWFZUSU6JRWK=
NCI-H719 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPGTWM2OD1|LkOwN|g1KM7:TR?= NEjGOphUSU6JRWK=
MC-CAR MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwNUS4NVch|ryP MVvTRW5ITVJ?
SIMA MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTCbG96UUN3ME2zMlU5PDF4IN88US=> MVrTRW5ITVJ?
SW872 M1PQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XjTWlEPTB;Mz63PFExOSEQvF2= MWrTRW5ITVJ?
HCC1187 M3[3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwN{izNVUh|ryP M4nGSXNCVkeHUh?=
EW-13 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnHUWtKSzVyPUOuPFM1OTdizszN MmDYV2FPT0WU
NCI-SNU-1 NGHYToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGZo9mUUN3ME20MlIyQTl7IN88US=> MUDTRW5ITVJ?
NCI-H226 M3TQWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkiwTWM2OD12LkOzOlA3KM7:TR?= NIC5WG9USU6JRWK=
RPMI-8866 NFG1cnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm2TWM2OD12LkO2NFI6KM7:TR?= NVXodVBsW0GQR1XS
OCI-AML2 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\XTWM2OD12LkW1NlMh|ryP Ml3VV2FPT0WU
LU-65 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu2TWM2OD12LkmzNFM{KM7:TR?= MofhV2FPT0WU
SK-N-DZ NXrKfYM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPMSpNVUUN3ME21MlY{PDZ3IN88US=> MYDTRW5ITVJ?
NB14 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3lRW9lUUN3ME21Mlk4OTN3IN88US=> M4fFSXNCVkeHUh?=
COLO-829 M3XjbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XVZWlEPTB;Nj6zN|M2QSEQvF2= MnW3V2FPT0WU
MHH-CALL-2 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq1fpZKSzVyPU[uOVE2ODhizszN NHvHVVBUSU6JRWK=
NCI-H1770 M2frWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG3dmVKSzVyPU[uOlY6ODRizszN MXHTRW5ITVJ?
ECC4 M4LHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnCTWM2OD14LkiyNVc6KM7:TR?= M2LFTHNCVkeHUh?=
A498 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LSbmlEPTB;Nj64O|E6OiEQvF2= MmqwV2FPT0WU
DMS-79 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzW4tqUUN3ME23MlA1PTF{IN88US=> MmLoV2FPT0WU
P30-OHK NE\Fe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorOTWM2OD15LkKxPVA3KM7:TR?= M1rJSHNCVkeHUh?=
D-502MG MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmyS4tKSzVyPUeuPVg{PiEQvF2= MWHTRW5ITVJ?
RCC10RGB NVPBcWxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRThwME[yPEDPxE1? NF76Z5NUSU6JRWK=
U-698-M NWnnOZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfqfXJKSzVyPUiuNlkzOjZizszN NH;CfXFUSU6JRWK=
BB49-HNC NFHNS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTTcWVxUUN3ME25MlQzOjZ3IN88US=> NXi5ZmtrW0GQR1XS
ES1 NUTqT3ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTZTWM2OD17Lk[4PVU3KM7:TR?= NX7mNlA5W0GQR1XS
MFM-223 NY\4WpJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjPfWdKSzVyPUGwMlk6OjdizszN NXfleoVsW0GQR1XS
C2BBe1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HGSmlEPTB;MUGuN|UzOyEQvF2= M{\Fb3NCVkeHUh?=
EB2 MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF{Lk[4PFEh|ryP MmLZV2FPT0WU
C8166 M2Lkbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF|LkizNFMh|ryP NHuzdIZUSU6JRWK=
ES3 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF|Lkm5O|ch|ryP NITHbZZUSU6JRWK=
NCI-H1650 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\5cWlEPTB;MU[uN|c3PSEQvF2= Ml3tV2FPT0WU
Mo-T NGPqcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHSTWM2OD1zNz60NFI6KM7:TR?= M3G3cnNCVkeHUh?=
NB7 M3LTcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ReGp3UUN3ME2xO{44PDZ5IN88US=> NXvqcG5zW0GQR1XS
ES7 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS5TWM2OD1zOT61OVA4KM7:TR?= MnHWV2FPT0WU
ES5 NVricJZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nvOGlEPTB;MkGuO|Y4OSEQvF2= MVPTRW5ITVJ?
MSTO-211H MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\2TGlEPTB;MkGuPFg2QCEQvF2= M4\LU3NCVkeHUh?=
U-87-MG MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ3LkG5OlYh|ryP NGLINHZUSU6JRWK=
THP-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfFTWM2OD1{OT63NlAyKM7:TR?= NHLNWFZUSU6JRWK=
NB10 NUH3U3JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorFTWM2OD1|MD6yOlk1KM7:TR?= NV71R5l1W0GQR1XS
NH-12 M3XKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXriRoFjUUN3ME2zN{4zODF5IN88US=> MVTTRW5ITVJ?
COLO-824 M{LPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPYcINKSzVyPUO0MlExODZizszN MnznV2FPT0WU
SKM-1 M1zBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjpfW1KSzVyPUO3Mlg1OjJizszN NHn5RlBUSU6JRWK=
NCI-H1838 NFrwUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\LTWM2OD1|OD6zO|k4KM7:TR?= NVHSUWNMW0GQR1XS
RL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\qTWM2OD1|OT6yOFc4KM7:TR?= M3zxOHNCVkeHUh?=
COLO-800 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3VTWM2OD12MD6wO|c{KM7:TR?= NFjn[XVUSU6JRWK=
KG-1 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\6dJVbUUN3ME20NE45QTV3IN88US=> MUfTRW5ITVJ?
TUR NXX2ToJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTRzLk[zPVkh|ryP M1y5SHNCVkeHUh?=
LNCaP-Clone-FGC NIrmeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRzLkmwNVch|ryP MkWyV2FPT0WU
NCI-H322M M3nPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR{LkW5PFQh|ryP MX3TRW5ITVJ?
LNCaP  MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr1epJKSzVyPUmxMlMhdk1? MnOwNlU2ODVzN{S=
C4-2 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDTTWM2OD16IH7N M2rWOlI2PTB3MUe0
JURKAT NUTFUZpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmmyNlQhcA>? Ml7ETWM2OD12MU[uOlYhdk1? NF\QO4czPDVzOUm5OS=>
MOLT-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfENlQhcA>? MnrVTWM2OD1{OEWzMlUhdk1? MVKyOFUyQTl7NR?=
REH NIXIXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z2V|I1KGh? NX;WNZdJUUN3ME2yPFcvPjhibl2= NVvzNZpGOjR3MUm5PVU>
NALM-6 NV[ySGplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV[yOEBp MUHJR|UxRTN2M{OwJI5O M4TkUlI1PTF7OUm1
RS 4;11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LzUFI1KGh? NVfyPJBSUUN3ME21NVkvODVibl2= M2TiNVI1PTF7OUm1
697 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTvNlQhcA>? NV;GbnllUUN3ME2yNVA4NjFibl2= MWGyOFUyQTl7NR?=
SIL-ALL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf3NlQhcA>? MY\JR|UxRTF7OT63O{BvVQ>? NV\zOoZ7OjR3MUm5PVU>
CEM NHy3cItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqyOEBp NG\z[IpKSzVyPUWyMlE5KG6P NGjPZpUzPDVzOUm5OS=>
P12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLUOWpSOjRiaB?= MlzQTWM2OD1|OT6yO{BvVQ>? MoLPNlQ2OTl7OUW=
NALM-16 M2mz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DvZ|I1KGh? NF3FfZFKSzVyPUm2MlI5KG6P MV2yOFUyQTl7NR?=
JURKAT M3zT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvvOFghcA>? MXvJR|UxRTF2Lki0JI5O NF:wcmMzPDVzOUm5OS=>
MOLT-4 NWKzXZcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPGO5RyPDhiaB?= M33nbWlEPTB;Mk[uOkBvVQ>? MYGyOFUyQTl7NR?=
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HMC-1.1 M2PIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDLZ5V6OS1zMECwJI5O NVjoOYFOPzJiaB?= NX3XR|NRcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MX2yNVI1OjF6OR?=
HMC-1.2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPPfYhIOS1zMECwJI5O M1;2T|czKGh? MY\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> M4\OXVIyOjR{MUi5
C2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXoPIYyNTFyMECgcm0> MnzZO|IhcA>? NWf0bGZEcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MWmyNVI1OjF6OR?=
CHP-212 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxMVEzPSCwTR?= MkTZNlQuOTJyIHi= MU\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M1zUVFIyOTZ7MkSy
IMR-32 Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTHNU0yOjVibl2= MXuyOE0yOjBiaB?= NFTZR5FqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MX2yNVE3QTJ2Mh?=
Kelly M1\KWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PmWFEuOTJ3IH7N Mm\3NlQuOTJyIHi= MYfpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NVnq[5hNOjFzNkmyOFI>
SH-EP MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTOWmJjOS1zMkWgcm0> NIj0Z3kzPC1zMkCgbC=> MWTpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NFHwW3YzOTF4OUK0Ni=>
SH-SY5Y M{nlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q5ZVEuOTJ3IH7N MV:yOE0yOjBiaB?= MVTpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M{HWeVIyOTZ7MkSy
SK-N-AS MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixMVEzPSCwTR?= M3TOS|I1NTF{MDDo MXjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n Mmq1NlEyPjl{NEK=
SK-N-BE NIewcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUixMVEzPSCwTR?= M2rHSlI1NTF{MDDo M{X4eYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= M33IRlIyOTZ7MkSy
KG1 M3zaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESyWmYyNzFyL{GwNEBvVQ>? Moj0O|IhcA>? NHPydHFFVVOR NXr6SlBPcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> Mon2NVk1PTh|NUi=
U937 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrBNU8yOC9zMECgcm0> NVv4RWFEPzJiaB?= MmDrSG1UVw>? MYjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M2n3WlE6PDV6M{W4
CAL62 NWjHPWVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rHblAvOS1zMECgcm0> NHX0XJo4OiCq MYLEUXNQ MVTFR|UxRTFwNDDuUS=> MnLlNVkzOjN3NUO=
OCUT-1 M{C4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOwMlEuOTByIH7N M2PG[|czKGh? NG\WZplFVVOR M4\qWGVEPTB;Mj6zJI5O MWOxPVIzOzV3Mx?=
8505C NHSyZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jCNFAvOS1zMECgcm0> MXu3NkBp MYLEUXNQ NXXPOoNkTUN3ME2zMlIhdk1? NGS3e5cyQTJ{M{W1Ny=>
ACT-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvWNE4yNTFyMDDuUS=> MoTRO|IhcA>? MlWySG1UVw>? NY\FW5RHTUN3ME21MlQhdk1? NYjURnNHOTl{MkO1OVM>
SW1736 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO3SpUxNjFvMUCwJI5O NWjmN3VEPzJiaB?= M1:ySmROW09? NFTRXm5GSzVyPUWuOkBvVQ>? NFfTSI4yQTJ{M{W1Ny=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID