BI 2536

For research use only.

Catalog No.S1109

156 publications

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's BI 2536 has been cited by 156 publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q3Z2lEPTB;MD6wNFc4PiEQvF2= M1O2Z3NCVkeHUh?=
ACN NH:0[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:4VppZUUN3ME2wMlAxQDR|IN88US=> NFTtZ5FUSU6JRWK=
TE-8 NVj5[oxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37yPWlEPTB;MD6wNFk1OSEQvF2= NXjaNFRvW0GQR1XS
LC-2-ad NWjYS|dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\hTWM2OD1yLkCxNFk{KM7:TR?= M2foXnNCVkeHUh?=
ALL-PO MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEGzJO69VQ>? MVrTRW5ITVJ?
EW-16 NHS2SHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOwTFF2UUN3ME2wMlAyOzN4IN88US=> NIjrUnBUSU6JRWK=
KM12 M1LtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfRXXkyUUN3ME2wMlAyOzR6IN88US=> M3XQdXNCVkeHUh?=
GI-1 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP6RWtkUUN3ME2wMlAyOzh|IN88US=> M4roV3NCVkeHUh?=
LS-411N M{faVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvZe25UUUN3ME2wMlAyPDB5IN88US=> MUnTRW5ITVJ?
ES8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DTU2lEPTB;MD6wNVQ6PCEQvF2= M{LiVHNCVkeHUh?=
SNU-C2B NY\EW|FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEG1NlYh|ryP MoDnV2FPT0WU
CESS NIq1bmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzRW9KSzVyPUCuNFE3ODJizszN M4DwV3NCVkeHUh?=
697 NFzo[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrdllKSzVyPUCuNFE3PjhizszN M3P5fXNCVkeHUh?=
NCI-H1963 M3jzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\iPWlEPTB;MD6wNVY4OyEQvF2= MUTTRW5ITVJ?
IA-LM M3fxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LpUmlEPTB;MD6wNVY5QCEQvF2= NEjqSWNUSU6JRWK=
SW954 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEG3NFUh|ryP NVX6ZZJWW0GQR1XS
RL95-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n3XGlEPTB;MD6wNVc{QCEQvF2= NXT1TXlwW0GQR1XS
LXF-289 M1;kS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\2XokzUUN3ME2wMlAyPzdizszN MnHVV2FPT0WU
OCUB-M NIXYRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\RTWM2OD1yLkCxPFI3KM7:TR?= NYHSSIVpW0GQR1XS
RKO M4fEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj4ZpM1UUN3ME2wMlAyQTh5IN88US=> NX3ldWRmW0GQR1XS
LOUCY NH3DNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\nfmlEPTB;MD6wNlA2KM7:TR?= NEnmcFJUSU6JRWK=
NOS-1 NI[2bYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\NVm5KSzVyPUCuNFIxQTNizszN MmS5V2FPT0WU
A4-Fuk MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLsNHRNUUN3ME2wMlAzOjF6IN88US=> Mom0V2FPT0WU
A388 NUDsNJV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2faXWlEPTB;MD6wNlIzPyEQvF2= MWnTRW5ITVJ?
TE-9 MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy2b3VKSzVyPUCuNFIzPjFizszN NXHMUnJNW0GQR1XS
KURAMOCHI NUH2O5E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXDTWM2OD1yLkCyNlg2KM7:TR?= NGm5SJdUSU6JRWK=
KALS-1 NGPLbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHWTWM2OD1yLkCyN|M5KM7:TR?= M1\veHNCVkeHUh?=
HOP-62 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEK0NkDPxE1? NFj2U5pUSU6JRWK=
RPMI-8402 NGfRNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PobmlEPTB;MD6wNlUxQCEQvF2= MY\TRW5ITVJ?
TE-1 M4i5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPCPYRKSzVyPUCuNFI2OTJizszN M3O3VXNCVkeHUh?=
CCRF-CEM MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPWTWM2OD1yLkCyOVQ{KM7:TR?= M{e2bnNCVkeHUh?=
HUTU-80 M3H5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\LNWlEPTB;MD6wNlYzPCEQvF2= M33WcHNCVkeHUh?=
NCI-H1648 NH\UeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fnbGlEPTB;MD6wNlY1PyEQvF2= MV;TRW5ITVJ?
HCE-4 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;GT25KSzVyPUCuNFI3QDJizszN NH3QTFJUSU6JRWK=
ETK-1 M1:2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEK3N|Yh|ryP NWX1S4JxW0GQR1XS
TE-15 NYXFZ5dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7wOXFKSzVyPUCuNFI4OzhizszN M4rRcXNCVkeHUh?=
BE-13 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEK3OEDPxE1? MUfTRW5ITVJ?
KE-37 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\5TWFXUUN3ME2wMlAzPzRzIN88US=> NF3ld4hUSU6JRWK=
NCI-H1355 NYLZb4YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjxR|dKSzVyPUCuNFI4QDNizszN MV\TRW5ITVJ?
TE-11 M4Kze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7rZnFRUUN3ME2wMlAzQDB7IN88US=> M4nLOnNCVkeHUh?=
BL-70 NFXXOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEK4OVch|ryP M2W0O3NCVkeHUh?=
ES6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrNO4hvUUN3ME2wMlAzQDhzIN88US=> MYTTRW5ITVJ?
GT3TKB NHqwVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEK5OVMh|ryP M1TDW3NCVkeHUh?=
LB647-SCLC NWG0SYpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEOxPVUh|ryP NHnDO25USU6JRWK=
NB13 M3fuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLwVIlKSzVyPUCuNFM{OTZizszN MWnTRW5ITVJ?
ST486 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP2cHBbUUN3ME2wMlA{OzN5IN88US=> NWrsV21oW0GQR1XS
NCI-H82 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfiZpdKSzVyPUCuNFM{PDNizszN NX\Hcm9RW0GQR1XS
NTERA-S-cl-D1 M3PBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEOzPVkh|ryP MUDTRW5ITVJ?
ES4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEO0OlMh|ryP NEPneHBUSU6JRWK=
SK-NEP-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DrZ2lEPTB;MD6wN|Q6QSEQvF2= NELB[plUSU6JRWK=
Becker MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTKcnRKSzVyPUCuNFM2PTVizszN NFexdmZUSU6JRWK=
A101D NWLX[lFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rMSmlEPTB;MD6wN|c1QCEQvF2= NUXqVIpIW0GQR1XS
SK-UT-1 NX;iN41{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDPcVJKSzVyPUCuNFM4PzRizszN NWTOemUxW0GQR1XS
SW982 MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv5TWM2OD1yLkCzO|kh|ryP NInFR4JUSU6JRWK=
TE-10 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWntOpZQUUN3ME2wMlA1ODR4IN88US=> NVzBOYI2W0GQR1XS
OVCAR-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMESwOVkh|ryP NV7FcmlJW0GQR1XS
KP-N-YS M4\CWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjBcY1TUUN3ME2wMlA1ODh3IN88US=> MYfTRW5ITVJ?
BL-41 NVP0dGU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHDTWM2OD1yLkC0NVI2KM7:TR?= MXvTRW5ITVJ?
MZ1-PC NUe4UGxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMESxNlch|ryP NFPkUZZUSU6JRWK=
PF-382 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfXW2RKSzVyPUCuNFQyQThizszN Mn;rV2FPT0WU
MOLT-13 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMESyN|gh|ryP MXvTRW5ITVJ?
HCC1599 NXTrNYFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;hbGlEPTB;MD6wOFI2QCEQvF2= MojUV2FPT0WU
IST-MEL1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XS[mlEPTB;MD6wOFQ1OiEQvF2= NUPYdmhsW0GQR1XS
LU-139 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPydVFsUUN3ME2wMlA1PDR{IN88US=> NX;Lcmh2W0GQR1XS
MS-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OzcGlEPTB;MD6wOFcxOSEQvF2= MlTMV2FPT0WU
MFH-ino NFLjUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4eFlTUUN3ME2wMlA2ODB|IN88US=> NU\RUmZZW0GQR1XS
IMR-5 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvETWM2OD1yLkC1NFIyKM7:TR?= NW\hdlJRW0GQR1XS
TE-5 NYDte3VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD1yLkC1NFY{KM7:TR?= NVHnTWVnW0GQR1XS
DJM-1 NX\JT3V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTMTWM2OD1yLkC1NVQzKM7:TR?= NYLpSZp4W0GQR1XS
NB17 NWHTdpJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEWyNFch|ryP MXfTRW5ITVJ?
KARPAS-45 NUTWdGlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu3TWM2OD1yLkC1N|U5KM7:TR?= NWXLboRNW0GQR1XS
TGBC1TKB MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[wdWlEPTB;MD6wOVQxPSEQvF2= NHfNZoVUSU6JRWK=
ML-2 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEW0NVQh|ryP Ml;CV2FPT0WU
no-10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEW0O|Qh|ryP NXjneVZVW0GQR1XS
CTV-1 NYXrdpRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Pk[2lEPTB;MD6wOVUxOiEQvF2= MXHTRW5ITVJ?
SJSA-1 NYTOTZRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4SzdGlEPTB;MD6wOVUzKM7:TR?= NWXYcJNwW0GQR1XS
HC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBWVJKSzVyPUCuNFU2QTdizszN NXvCenVwW0GQR1XS
TE-12 NVvGPGs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X4eWlEPTB;MD6wOVYyOyEQvF2= NWL6NGhHW0GQR1XS
KY821 NYnPcHdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;w[GlEPTB;MD6wOVY{OiEQvF2= M3LSdHNCVkeHUh?=
TALL-1 M4DreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHVTWM2OD1yLkC1O|A5KM7:TR?= NWC0Ro93W0GQR1XS
DEL M4Dqc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PuUGlEPTB;MD6wOVcxQSEQvF2= NGnCcnlUSU6JRWK=
TE-6 NGLIfG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTn[W1KUUN3ME2wMlA2PzJ{IN88US=> M1vCW3NCVkeHUh?=
SK-LMS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWNGlEPTB;MD6wOVgxPSEQvF2= NVLvXWRoW0GQR1XS
EW-1 NVLmb5RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\hS|VKSzVyPUCuNFU5OzdizszN M1fPUXNCVkeHUh?=
8-MG-BA M1n0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvrU5RKSzVyPUCuNFU5PTFizszN MXjTRW5ITVJ?
NALM-6 NFflbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:wU4p6UUN3ME2wMlA2QTd|IN88US=> MkHHV2FPT0WU
LB771-HNC M1HvcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWxdmZKSzVyPUCuNFU6PzlizszN NEPUOVBUSU6JRWK=
HT-144 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwME[xN{DPxE1? MmDRV2FPT0WU
KM-H2 M4LHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmzTWM2OD1yLkC2NlIyKM7:TR?= NFT4fpFUSU6JRWK=
SF268 NGnQTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwME[yPFYh|ryP NGnPT4xUSU6JRWK=
RS4-11 NVnmXpk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoexTWM2OD1yLkC2N|A1KM7:TR?= NEPFdIxUSU6JRWK=
MHH-PREB-1 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV65Z5RHUUN3ME2wMlA3OzF7IN88US=> NFi5dIxUSU6JRWK=
ATN-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jpcGlEPTB;MD6wOlM1PSEQvF2= MlLoV2FPT0WU
BB30-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Wyc2lEPTB;MD6wOlQ{PiEQvF2= NHLMV4dUSU6JRWK=
CPC-N M2\qWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwME[1NlQh|ryP MkjrV2FPT0WU
NB1 NX[4bGVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwME[2NVMh|ryP NYTEOGhbW0GQR1XS
KS-1 NFPMfWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwME[3OFgh|ryP NYfFdoNtW0GQR1XS
RXF393 NXX4TmZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXsZmtKSzVyPUCuNFY4PjRizszN NXjRTHdwW0GQR1XS
IST-SL2 NHLLfGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEewNFQh|ryP Ml\nV2FPT0WU
GI-ME-N NInBRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnvcJRKSzVyPUCuNFczQDZizszN NEf1cnpUSU6JRWK=
VA-ES-BJ NEHSWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEe0O|Uh|ryP MUjTRW5ITVJ?
NCI-H1581 M1fHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH2TWM2OD1yLkC3OFc5KM7:TR?= MWfTRW5ITVJ?
U-266 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHi[plKSzVyPUCuNFc1QTdizszN NYD2Zoh{W0GQR1XS
DMS-114 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHPTWM2OD1yLkC3OVI5KM7:TR?= NFjkb|VUSU6JRWK=
NCI-H187 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;hTWM2OD1yLkC3O|I3KM7:TR?= NVXONWQ{W0GQR1XS
SW962 NXXOfpJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PwUmlEPTB;MD6wO|g{QSEQvF2= MnPCV2FPT0WU
MONO-MAC-6 M2rxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEe5PFYh|ryP MWfTRW5ITVJ?
MOLT-16 NYToSohjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEixNlEh|ryP NYrtU4E6W0GQR1XS
KNS-42 NULPWGZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEixOlEh|ryP Mne2V2FPT0WU
CMK NGexcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvJT4JKSzVyPUCuNFgzOjVizszN NF3CUIJUSU6JRWK=
Ramos-2G6-4C10 NFHmdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ndpdKSzVyPUCuNFgzOjVizszN MUnTRW5ITVJ?
Daudi M3m3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjNTWM2OD1yLkC4NlU3KM7:TR?= M17IfHNCVkeHUh?=
NCI-H510A M4H3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULyZ49VUUN3ME2wMlA5OzN4IN88US=> NEXudnhUSU6JRWK=
LB831-BLC NXHwcmJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT0b2RKSzVyPUCuNFg2PjFizszN Mo\VV2FPT0WU
HEL NHPiOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXmTWM2OD1yLkC4OlY5KM7:TR?= MnHNV2FPT0WU
LU-134-A NXnaepdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3aeWUxUUN3ME2wMlA5PzB6IN88US=> NXTiNHBZW0GQR1XS
NCI-H1694 NHO0bodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLrTWM2OD1yLkC4O|Q1KM7:TR?= M1TIU3NCVkeHUh?=
KGN NY\RdG1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEi3OVkh|ryP MVfTRW5ITVJ?
A253 Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYexcmJQUUN3ME2wMlA5QDJ{IN88US=> NGe1eGtUSU6JRWK=
DG-75 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3yzT2lEPTB;MD6wPFkzOiEQvF2= NW\VPZZMW0GQR1XS
MOLT-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPPfIdKSzVyPUCuNFg6QDNizszN MXrTRW5ITVJ?
NCI-SNU-5 NYnSTphDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEmyOVgh|ryP NWnxSnF5W0GQR1XS
ONS-76 NETENIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3ueoFKSzVyPUCuNFkzPzZizszN MX;TRW5ITVJ?
NCI-H446 NFzhNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH2Xo1KSzVyPUCuNFk1PjJizszN NUfLZ2E5W0GQR1XS
COR-L279 NH7DVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDRTWM2OD1yLkC5OVU3KM7:TR?= M3LkfXNCVkeHUh?=
Calu-6 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEm1PVgh|ryP NVnOe2R7W0GQR1XS
BC-3 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rqT2lEPTB;MD6wPVY3OiEQvF2= NFPFbnBUSU6JRWK=
NCI-H2126 M{LQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjtTnNHUUN3ME2wMlA6PzlzIN88US=> NFPUNIlUSU6JRWK=
NCI-H1882 NEnkSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XyfmlEPTB;MD6wPVgxQSEQvF2= NH\nVo9USU6JRWK=
BB65-RCC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjjR4lQUUN3ME2wMlExOjl2IN88US=> NUDrUmxMW0GQR1XS
DU-4475 NHzybXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXQdXhKSzVyPUCuNVA1ODdizszN NV\BRml6W0GQR1XS
NCI-H526 NUO1NpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG5e5RKSzVyPUCuNVA1PCEQvF2= NXz3epREW0GQR1XS
NEC8 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfsOI5iUUN3ME2wMlExPTJ3IN88US=> NEfjWJZUSU6JRWK=
NCI-H1304 NEG1SYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nyUGlEPTB;MD6xNFU6PCEQvF2= MkXsV2FPT0WU
L-540 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvrPWNWUUN3ME2wMlExPzB6IN88US=> NVzRVpJbW0GQR1XS
NCI-SNU-16 NIfUWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\nRXZKSzVyPUCuNVA4PDJizszN MVfTRW5ITVJ?
HD-MY-Z M1m5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7jTWM2OD1yLkGwPFU3KM7:TR?= NXnDPHpvW0GQR1XS
K-562 M3q2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3tfXJKSzVyPUCuNVA5PThizszN MUTTRW5ITVJ?
JAR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHlNnFKSzVyPUCuNVA6OjVizszN MonNV2FPT0WU
MZ2-MEL MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDYUYRlUUN3ME2wMlEyODVizszN NYDHfplbW0GQR1XS
L-363 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXDTWM2OD1yLkGxNFc6KM7:TR?= MX\TRW5ITVJ?
BV-173 NY\lO4ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPzVpdTUUN3ME2wMlEyOjR|IN88US=> MlvnV2FPT0WU
NCI-H524 NFzDb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jQRmlEPTB;MD6xNVI4PCEQvF2= MoXIV2FPT0WU
EoL-1-cell MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMUG2O|Ih|ryP Mom1V2FPT0WU
K052 NELWfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMUG3NVIh|ryP NIjCWYxUSU6JRWK=
TK10 M4LkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ixdmlEPTB;MD6xNVczQCEQvF2= NFzz[5FUSU6JRWK=
KU812 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjLdINKSzVyPUCuNVIxPDRizszN MkK5V2FPT0WU
RPMI-8226 MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMUKwOVIh|ryP M2rQd3NCVkeHUh?=
MZ7-mel NF\DOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETHRWJKSzVyPUCuNVIzOzdizszN MUjTRW5ITVJ?
SK-PN-DW NV7lXlB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j4XWlEPTB;MD6xNlI5PyEQvF2= NGO3NnVUSU6JRWK=
SR M2DrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2joR2lEPTB;MD6xNlQ1OSEQvF2= M4HL[HNCVkeHUh?=
RPMI-6666 M3HHc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnoZ|FQUUN3ME2wMlEzPzR|IN88US=> MlXkV2FPT0WU
no-11 MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUK4Olkh|ryP NX\5cnVuW0GQR1XS
EW-3 NX7CSIlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD2THVQUUN3ME2wMlEzQDl|IN88US=> NWnS[4s{W0GQR1XS
LAMA-84 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T6e2lEPTB;MD6xN|E5PyEQvF2= Ml;FV2FPT0WU
HT MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnGTWM2OD1yLkGzOVc1KM7:TR?= MWrTRW5ITVJ?
KP-N-RT-BM-1 NY\qeFlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXroOYQ2UUN3ME2wMlE{PjF{IN88US=> NGW3bpNUSU6JRWK=
NCI-H747 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLzXpVxUUN3ME2wMlE{PyEQvF2= NXi2[2lLW0GQR1XS
NCCIT M3jsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMUO5N|kh|ryP NF3scXdUSU6JRWK=
MLMA NV7MN|NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXobY5KSzVyPUCuNVQyPjdizszN NYT6OmIzW0GQR1XS
LP-1 NVfnT|NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\lUWlEPTB;MD6xOFI1KM7:TR?= NYKw[VgyW0GQR1XS
CAL-148 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDxTWM2OD1yLkG0OFg{KM7:TR?= M172W3NCVkeHUh?=
GB-1 M1TXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PaW2lEPTB;MD6xOFUzPiEQvF2= M1;NW3NCVkeHUh?=
COR-L88 NX\YZ2xUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTvTWM2OD1yLkG0PFAzKM7:TR?= NXXKUGtxW0GQR1XS
NKM-1 M2TkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPL[GEzUUN3ME2wMlE1QTB4IN88US=> NFPOZ2FUSU6JRWK=
NB5 NUDWTIl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMUW0OlIh|ryP NXz5dHJZW0GQR1XS
SH-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi2WGRHUUN3ME2wMlE2PDZ4IN88US=> NI\GSHVUSU6JRWK=
EM-2 M3LLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojaTWM2OD1yLkG1OFY4KM7:TR?= NVSxV3NTW0GQR1XS
TGBC24TKB NHj3TXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXzZolKSzVyPUCuNVU3PTlizszN MUTTRW5ITVJ?
SCLC-21H MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ZemFHUUN3ME2wMlE2PzB{IN88US=> NWHv[41PW0GQR1XS
COLO-684 M1zQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMUW3NlEh|ryP NEP0PHZUSU6JRWK=
KINGS-1 NGGzUXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzHOpZ4UUN3ME2wMlE2QTFizszN M4P5WnNCVkeHUh?=
LS-123 NVy3NJg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\LTWM2OD1yLkG1PVE4KM7:TR?= MojmV2FPT0WU
MC116 NF[0emVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfUZYFKSzVyPUCuNVYyPThizszN NYDJNlNUW0GQR1XS
SU-DHL-1 NXXXd3I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnrTWM2OD1yLkG2NlA3KM7:TR?= NETGTJdUSU6JRWK=
NCI-H64 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;RbplTUUN3ME2wMlE3OzR5IN88US=> NXLpS4QzW0GQR1XS
HCE-T M3LhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHyNlRKSzVyPUCuNVY2ODRizszN MnvEV2FPT0WU
LOXIMVI NXvhVWlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnwR4hYUUN3ME2wMlE3QTR7IN88US=> MUnTRW5ITVJ?
ARH-77 NXHybWNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfZU2lKSzVyPUCuNVc{PzlizszN MV;TRW5ITVJ?
DOHH-2 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HSWmlEPTB;MD6xO|Y4OiEQvF2= M{i5b3NCVkeHUh?=
COLO-320-HSR M3X4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTGTWM2OD1yLkG4NVU1KM7:TR?= NVzqUHJoW0GQR1XS
NB6 M1jpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi3VGNEUUN3ME2wMlE5PTZ4IN88US=> NEXYNpVUSU6JRWK=
L-428 NEHrNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS1WnZuUUN3ME2wMlE5QDF|IN88US=> NUjWOVBNW0GQR1XS
SNB75 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;meZRKSzVyPUCuNVg5OjRizszN NI\jWZBUSU6JRWK=
NCI-H2141 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nlcWlEPTB;MD6xPVAyOSEQvF2= NGXnTZdUSU6JRWK=
KARPAS-299 NVHk[m57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTPW2ZjUUN3ME2wMlE6OjRzIN88US=> NVWySnlEW0GQR1XS
LC4-1 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DLbWlEPTB;MD6xPVUxOiEQvF2= Mnf4V2FPT0WU
UACC-257 NITqNVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq1TWM2OD1yLkG5PVQ4KM7:TR?= NELpOnhUSU6JRWK=
EVSA-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnYTWM2OD1yLkKwN|EzKM7:TR?= NUG5Vo1ZW0GQR1XS
JiyoyeP-2003 NWexeFJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TzUWlEPTB;MD6yNFQ4PyEQvF2= M3PBb3NCVkeHUh?=
NCI-H720 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnaN2NKSzVyPUCuNlA2OjVizszN NHvVSo5USU6JRWK=
GAK M2OzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHXU|lKSzVyPUCuNlEyQDlizszN NX3LPZVmW0GQR1XS
HH MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvnTWM2OD1yLkKxOFA2KM7:TR?= NGXZeYVUSU6JRWK=
NCI-H1436 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojkTWM2OD1yLkKxOFY1KM7:TR?= NULaV4JiW0GQR1XS
GR-ST MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnxTWM2OD1yLkKxOFg5KM7:TR?= M{jYTHNCVkeHUh?=
BC-1 NIjGXolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGwTWM2OD1yLkKyOlE3KM7:TR?= NWfadGs3W0GQR1XS
SIG-M5 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMkK3Nlch|ryP MljrV2FPT0WU
NCI-H345 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHxTWM2OD1yLkKzPFA2KM7:TR?= NYTwfohiW0GQR1XS
OPM-2 NEnDWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7IR4pKSzVyPUCuNlM5QDJizszN NVrWcYR1W0GQR1XS
LB1047-RCC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMkS0NUDPxE1? M1X6XnNCVkeHUh?=
CTB-1 NXThc3NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPqTWM2OD1yLkK0OFk{KM7:TR?= MW\TRW5ITVJ?
A3-KAW MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny3TWM2OD1yLkK1N|QyKM7:TR?= NXrrW3pFW0GQR1XS
SF126 NFLaWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[5RYNKSzVyPUCuNlU{QDNizszN Mlz5V2FPT0WU
KARPAS-422 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzlPINyUUN3ME2wMlI2PDN3IN88US=> MYfTRW5ITVJ?
MEG-01 M1niTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjFVpNKSzVyPUCuNlU3PzNizszN MoC3V2FPT0WU
NCI-H209 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLxW4lKSzVyPUCuNlY{PzRizszN M3TDbXNCVkeHUh?=
SBC-1 M3TOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO2c4RKSzVyPUCuNlY2KM7:TR?= NX:yXodmW0GQR1XS
K5 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnXTWM2OD1yLkK2PVg1KM7:TR?= NX;5Z4pMW0GQR1XS
QIMR-WIL NXrtZYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTaTWM2OD1yLkK3NVU2KM7:TR?= NHHM[nVUSU6JRWK=
NMC-G1 NEW4[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDzTWM2OD1yLkK4NlE4KM7:TR?= NGDmS3RUSU6JRWK=
IST-MES1 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO1VFJKSzVyPUCuNlkzOzhizszN MlX4V2FPT0WU
SW684 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TmZWlEPTB;MD6zNFA1PyEQvF2= MnnyV2FPT0WU
MV-4-11 M4n3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXiUWhKSzVyPUCuN|A4QDhizszN MVHTRW5ITVJ?
LAN-6 NHfLUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwM{G1O|Ih|ryP M3jPOHNCVkeHUh?=
RH-1 NGfSd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEiwS|lKSzVyPUCuN|E5PzFizszN MnHJV2FPT0WU
CP66-MEL M4W0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwM{G4O|gh|ryP MnHQV2FPT0WU
EC-GI-10 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED3XpVKSzVyPUCuN|I6QDdizszN MXPTRW5ITVJ?
GDM-1 M1PxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLnTWM2OD1yLkOzNFU6KM7:TR?= MWHTRW5ITVJ?
IST-SL1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknkTWM2OD1yLkO0PVE1KM7:TR?= NFT3ZWhUSU6JRWK=
KMOE-2 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXBRnBuUUN3ME2wMlM2OTd3IN88US=> NGTFbnNUSU6JRWK=
OS-RC-2 NF;jTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjiOYNKSzVyPUCuN|U2PDRizszN M1jTUnNCVkeHUh?=
HDLM-2 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLZT4o5UUN3ME2wMlM4QDF2IN88US=> NVjYcphKW0GQR1XS
DSH1 M3fqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jFSWlEPTB;MD6zPFY{OSEQvF2= MULTRW5ITVJ?
LS-1034 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1roNGlEPTB;MD6zPFk2PCEQvF2= NWHEU40yW0GQR1XS
LB373-MEL-D NIWwbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\Ue|RpUUN3ME2wMlM6OTl5IN88US=> NFK3d3FUSU6JRWK=
GOTO MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwNEKxNVgh|ryP NYTxSnhtW0GQR1XS
MRK-nu-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfObXhKSzVyPUCuOFIzODVizszN NGHTOWdUSU6JRWK=
SK-MM-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNEO0OFIh|ryP M4DTPHNCVkeHUh?=
BOKU Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r2cWlEPTB;MD60N|c6OiEQvF2= NVvBWmxmW0GQR1XS
NOMO-1 Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNEO4OkDPxE1? NVjmOVRGW0GQR1XS
J-RT3-T3-5 NXj3[|lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\y[GlEPTB;MD60OFg4QCEQvF2= M4PQRnNCVkeHUh?=
COLO-668 MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHiTWM2OD1yLkS1OlY5KM7:TR?= M1rPS3NCVkeHUh?=
SF539 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3TNmRtUUN3ME2wMlQ5Pjh2IN88US=> MojtV2FPT0WU
LB2518-MEL NIjRdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNEm3NFMh|ryP MkD3V2FPT0WU
TE-441-T M{DUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jscmlEPTB;MD61NFEzKM7:TR?= NVTzTWxnW0GQR1XS
MDA-MB-134-VI M2DOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;UWGlEPTB;MD61NFkzOSEQvF2= NHXqN|RUSU6JRWK=
SCC-3 NHLPVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHEWY9KSzVyPUCuOVE5PzNizszN MorZV2FPT0WU
KLE MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTPOG14UUN3ME2wMlUzOTdzIN88US=> NYTCeoZJW0GQR1XS
LB2241-RCC NGfmdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PjfWlEPTB;MD61NlUzPSEQvF2= MXLTRW5ITVJ?
NCI-H1417 Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjUUphKSzVyPUCuOVM1OzVizszN NV:1V2V4W0GQR1XS
NCI-H2081 NWjHfoJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT3e4hKSzVyPUCuOVg3OTFizszN NEfMcGRUSU6JRWK=
NCI-H1522 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj2eVdKUUN3ME2wMlU6Ozh|IN88US=> M4LzRXNCVkeHUh?=
NCI-H889 NYroOppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrXTWM2OD1yLkW5PFQ1KM7:TR?= M3HZNnNCVkeHUh?=
CGTH-W-1 MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M165bWlEPTB;MD62NFc2PSEQvF2= NFr0fHpUSU6JRWK=
EB-3 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mOGZvUUN3ME2wMlYyOTV|IN88US=> M3L1enNCVkeHUh?=
D-336MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNkG3PVEh|ryP M{PsUnNCVkeHUh?=
LC-1F NUDydHBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:yNWxyUUN3ME2wMlYzPTl{IN88US=> NHHEeG1USU6JRWK=
MHH-NB-11 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;ic2pKSzVyPUCuOlM5ODFizszN MV3TRW5ITVJ?
SK-N-FI MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OyTmlEPTB;MD62N|kyKM7:TR?= M4rKbnNCVkeHUh?=
NCI-H69 NUfWcG84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHy[4VoUUN3ME2wMlY1QDd7IN88US=> NHXVRY5USU6JRWK=
SCH NV7UT|VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXQTJZWUUN3ME2wMlY3ODJ|IN88US=> MVLTRW5ITVJ?
LS-513 NFnHeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL3TWM2OD1yLk[3NlU6KM7:TR?= NF\zbXhUSU6JRWK=
CP67-MEL NGjk[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3HTWM2OD1yLk[3OVk3KM7:TR?= MlHpV2FPT0WU
GCIY NXu0SnZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwN{CzOlMh|ryP NHjC[FlUSU6JRWK=
SHP-77 NU\qeYVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WxfGlEPTB;MD63NFc{PCEQvF2= NYXjVZZ7W0GQR1XS
EHEB Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq1TWM2OD1yLkexPFU1KM7:TR?= MUTTRW5ITVJ?
D-247MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPnTWM2OD1yLkezNlMzKM7:TR?= MV3TRW5ITVJ?
Raji NHm5UnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33RdWlEPTB;MD63OFk5QSEQvF2= M4fXe3NCVkeHUh?=
MPP-89 MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPEfmlKSzVyPUCuO|U6PzhizszN M{TTTnNCVkeHUh?=
EKVX M1nMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULUdHRqUUN3ME2wMlc6ODd|IN88US=> M1TpR3NCVkeHUh?=
HCC2218 NEPsbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DSemlEPTB;MD63PVE{OSEQvF2= MVXTRW5ITVJ?
KNS-81-FD MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwOEGwNVEh|ryP NGT2ZWJUSU6JRWK=
HCC2157 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwOES5OVEh|ryP Mk\EV2FPT0WU
BT-474 NE\FW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfGfoNKSzVyPUCuPFg5PTRizszN NHfoZ4hUSU6JRWK=
NCI-H748 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K5NWlEPTB;MD65NVIh|ryP NYPTbnp3W0GQR1XS
EW-24 NEO5NFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwOUKwNFIh|ryP MV;TRW5ITVJ?
D-263MG NHOzWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PYSWlEPTB;MD65OFUyOiEQvF2= NGqwb2lUSU6JRWK=
OMC-1 NIP5clVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwOU[zO|Mh|ryP NVvrdFc6W0GQR1XS
NCI-H2196 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrxTWM2OD1yLkm3O|c4KM7:TR?= NUnkZ496W0GQR1XS
HAL-01 M3TtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfZbI1XUUN3ME2wMlk6QDd{IN88US=> MYDTRW5ITVJ?
NCI-H2107 NUDiemZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjRTWM2OD1zLkCxPFU1KM7:TR?= MWDTRW5ITVJ?
LB996-RCC NH\nfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vNTmlEPTB;MT6wPFA2OSEQvF2= MVPTRW5ITVJ?
NCI-H1395 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf0RmpFUUN3ME2xMlExPjdizszN NGKydpJUSU6JRWK=
CHP-126 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwMU[xPVkh|ryP M37mV3NCVkeHUh?=
NB69 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwMk[xOFgh|ryP NGjydY9USU6JRWK=
CAS-1 NWLPdWpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HpXmlEPTB;MT6zOFI{OSEQvF2= NYLxfW1kW0GQR1XS
JVM-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rzb2lEPTB;MT60O|g2PSEQvF2= M3HBOXNCVkeHUh?=
DMS-153 NXm4UoFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XKdGlEPTB;MT61O|Y4PCEQvF2= M4[5fHNCVkeHUh?=
SK-MEL-2 NVS4VoF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xj[mlEPTB;MT63NVc5QSEQvF2= MnvhV2FPT0WU
NCI-H1155 M3Kzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwN{O2O|Yh|ryP M3HxT3NCVkeHUh?=
NCI-H1092 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HzSmlEPTB;MT63OlE5OiEQvF2= M3\KOHNCVkeHUh?=
LU-165 NHraS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDsTWM2OD1zLki2OFc3KM7:TR?= NH2yT5RUSU6JRWK=
HL-60 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf2XW83UUN3ME2xMlk6QTB6IN88US=> NYPMdXlHW0GQR1XS
REH NFPoUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i1UWlEPTB;Mj6wNFU5OiEQvF2= MXzTRW5ITVJ?
JVM-2 NX\UPGlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\QS2RKSzVyPUKuNFYyOzVizszN NXfnVHFEW0GQR1XS
MN-60 NHi0fZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjXcXpKSzVyPUKuNVc{ODhizszN NYXjeFV5W0GQR1XS
SCC-15 NUjQW4JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJwMkCyO{DPxE1? NXGxcldOW0GQR1XS
SNU-C1 NXG5eJRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PpeGlEPTB;Mj6yNVM1OyEQvF2= NFHuOGFUSU6JRWK=
SK-MEL-1 NXTLeG5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Gc2pEUUN3ME2yMlMzODR5IN88US=> NEfN[plUSU6JRWK=
TGW M17ufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwM{WwNlch|ryP M4XsZ3NCVkeHUh?=
CA46 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjjeJdIUUN3ME2yMlc2QTZ5IN88US=> Mk[4V2FPT0WU
NCI-H23 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfN[XVKSzVyPUKuPFA4QTFizszN NGHZdoFUSU6JRWK=
MMAC-SF M3PWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXNU4dKSzVyPUKuPFY3OjhizszN M2DSXXNCVkeHUh?=
NCI-H2171 NGG2e3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;QbnVKSzVyPUOuNFM1PDhizszN M2jsTHNCVkeHUh?=
A704 M1e5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNwMUSxPVQh|ryP NHqybodUSU6JRWK=
DB M1SwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\RXmlEPTB;Mz6yOVU4PiEQvF2= Moq5V2FPT0WU
NCI-H719 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PORmlEPTB;Mz6zNFM5PCEQvF2= M3vhS3NCVkeHUh?=
MC-CAR MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPONYNKSzVyPUOuOVQ5OTdizszN M4jrenNCVkeHUh?=
SIMA NITFcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[4eGlEPTB;Mz61PFQyPiEQvF2= MnLwV2FPT0WU
SW872 NGLwNVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LUS2lEPTB;Mz63PFExOSEQvF2= MX;TRW5ITVJ?
HCC1187 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwN{izNVUh|ryP NWDwe2M{W0GQR1XS
EW-13 M4rQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHuUoFFUUN3ME2zMlg{PDF5IN88US=> MoK2V2FPT0WU
NCI-SNU-1 NUS4eoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\aSmlEPTB;ND6yNVk6QSEQvF2= NGXOWZhUSU6JRWK=
NCI-H226 M1e2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTRwM{O2NFYh|ryP M{X6TXNCVkeHUh?=
RPMI-8866 NULic21UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTRwM{[wNlkh|ryP M1;rNnNCVkeHUh?=
OCI-AML2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTRwNUWyN{DPxE1? M2jUSXNCVkeHUh?=
LU-65 NX25R2pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH35dolKSzVyPUSuPVMxOzNizszN NXzETVVIW0GQR1XS
SK-N-DZ MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTVwNkO0OlUh|ryP NUH4b4pDW0GQR1XS
NB14 NF7OcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhNXRKSzVyPUWuPVcyOzVizszN M4rGV3NCVkeHUh?=
COLO-829 NWT1NXI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n5eWlEPTB;Nj6zN|M2QSEQvF2= M3;ES3NCVkeHUh?=
MHH-CALL-2 M3\tcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O1dmlEPTB;Nj61NVUxQCEQvF2= NYPOUphKW0GQR1XS
NCI-H1770 NVXIRY9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLqTWM2OD14Lk[2PVA1KM7:TR?= MVTTRW5ITVJ?
ECC4 NYPocXk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17ONGlEPTB;Nj64NlE4QSEQvF2= M{XkUnNCVkeHUh?=
A498 NVnIeWo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTmTWM2OD14Lki3NVkzKM7:TR?= MnXtV2FPT0WU
DMS-79 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[zTWM2OD15LkC0OVEzKM7:TR?= MmHwV2FPT0WU
P30-OHK NEXnPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\BSGlEPTB;Nz6yNVkxPiEQvF2= MXnTRW5ITVJ?
D-502MG M1OyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTLRWtOUUN3ME23Mlk5OzZizszN NVf3d29pW0GQR1XS
RCC10RGB NUfrPWx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDwUI9KSzVyPUiuNFYzQCEQvF2= M3PvPXNCVkeHUh?=
U-698-M MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRThwMkmyNlYh|ryP M2POT3NCVkeHUh?=
BB49-HNC NX\SZotrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfYTWM2OD17LkSyNlY2KM7:TR?= M3exNnNCVkeHUh?=
ES1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n6SmlEPTB;OT62PFk2PiEQvF2= MlTTV2FPT0WU
MFM-223 NEnuWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljuTWM2OD1zMD65PVI4KM7:TR?= NHHBSphUSU6JRWK=
C2BBe1 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDKTWM2OD1zMT6zOVI{KM7:TR?= MlLCV2FPT0WU
EB2 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF{Lk[4PFEh|ryP M1HwTHNCVkeHUh?=
C8166 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDFZZZsUUN3ME2xN{45OzB|IN88US=> Mof2V2FPT0WU
ES3 NEj6[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrKe25lUUN3ME2xN{46QTd5IN88US=> M37aUXNCVkeHUh?=
NCI-H1650 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;6U|FKSzVyPUG2MlM4PjVizszN MV\TRW5ITVJ?
Mo-T NYTpd4RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLtbXJKSzVyPUG3MlQxOjlizszN NHv2dnNUSU6JRWK=
NB7 NUCxcpdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7DfJo6UUN3ME2xO{44PDZ5IN88US=> Mmr0V2FPT0WU
ES7 NWXxVYpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfRN4xKSzVyPUG5MlU2ODdizszN MlfGV2FPT0WU
ES5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJzLke2O|Eh|ryP NIn6N5lUSU6JRWK=
MSTO-211H NF7zOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\lTWM2OD1{MT64PFU5KM7:TR?= MVTTRW5ITVJ?
U-87-MG M2jYUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXBPXBKSzVyPUK1MlE6PjZizszN MW\TRW5ITVJ?
THP-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ7LkeyNFEh|ryP M{PK[nNCVkeHUh?=
NB10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjHNlM2UUN3ME2zNE4zPjl2IN88US=> MmDLV2FPT0WU
NH-12 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC1N3BUUUN3ME2zN{4zODF5IN88US=> M1nIXnNCVkeHUh?=
COLO-824 NUjYbZg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXzTWM2OD1|ND6xNFA3KM7:TR?= NF32Xm1USU6JRWK=
SKM-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PHWmlEPTB;M{euPFQzOiEQvF2= MlX1V2FPT0WU
NCI-H1838 Mn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjiUVdKSzVyPUO4MlM4QTdizszN M4HFO3NCVkeHUh?=
RL NVfoVW9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X3W2lEPTB;M{muNlQ4PyEQvF2= MYfTRW5ITVJ?
COLO-800 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7STWM2OD12MD6wO|c{KM7:TR?= NVqwWWhiW0GQR1XS
KG-1 NXmzWHpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX0TWM2OD12MD64PVU2KM7:TR?= MmHJV2FPT0WU
TUR M2jX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRzLk[zPVkh|ryP MkHKV2FPT0WU
LNCaP-Clone-FGC NX3ZfVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\VTFRKSzVyPUSxMlkxOTdizszN MonGV2FPT0WU
NCI-H322M NX35NWo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPDRZdVUUN3ME20Nk42QTh2IN88US=> NFzQbndUSU6JRWK=
LNCaP  MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTlzLkOgcm0> MkfBNlU2ODVzN{S=
C4-2 NFfjSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRThibl2= MVmyOVUxPTF5NB?=
JURKAT MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLUlI1KGh? MmrxTWM2OD12MU[uOlYhdk1? NVHjO2xPOjR3MUm5PVU>
MOLT-4 NV3JbY1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13UblI1KGh? M2nNVGlEPTB;Mki1N{42KG6P M1Ps[VI1PTF7OUm1
REH MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWyOEBp M3zUUGlEPTB;Mki3MlY5KG6P NEDaWHMzPDVzOUm5OS=>
NALM-6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnieHQ6OjRiaB?= NYno[|l1UUN3ME2zOFM{OCCwTR?= MUeyOFUyQTl7NR?=
RS 4;11 NGHvRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorjNlQhcA>? NYqydnhpUUN3ME21NVkvODVibl2= NE\KS2QzPDVzOUm5OS=>
697 M2PoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\UbIYzPCCq Mo\FTWM2OD1{MUC3MlEhdk1? MmPvNlQ2OTl7OUW=
SIL-ALL M3\ufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXrNlQhcA>? M3XxPWlEPTB;MUm5Mlc4KG6P MmL5NlQ2OTl7OUW=
CEM MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITacI8zPCCq M1qwWmlEPTB;NUKuNVghdk1? NEnOV5AzPDVzOUm5OS=>
P12 NEfsOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq5clczPCCq MY\JR|UxRTN7LkK3JI5O M1TjWFI1PTF7OUm1
NALM-16 M{TLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Cd4pYOjRiaB?= MXvJR|UxRTl4LkK4JI5O MVSyOFUyQTl7NR?=
JURKAT M4fJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXGdmtMPDhiaB?= MXXJR|UxRTF2Lki0JI5O NGnLfHczPDVzOUm5OS=>
MOLT-4 NXXmU5NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUe0PEBp MlTiTWM2OD1{Nj62JI5O NVjLRYhJOjR3MUm5PVU>
REH MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLmWIo1QCCq NU\0cXozUUN3ME20OE44OSCwTR?= M3\QfFI1PTF7OUm1
NALM-6 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:0PEBp MlmyTWM2OD1{Mz6yOkBvVQ>? MnewNlQ2OTl7OUW=
RS 4;11 M1\lWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUG0PEBp NFTNSmxKSzVyPUG2OE4zQCCwTR?= NVnrbYtnOjR3MUm5PVU>
697 M3PJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTCV4s1QCCq M2\Ze2lEPTB;M{C1MlMhdk1? NWr3[WppOjR3MUm5PVU>
SIL-ALL NIHnWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fLRVQ5KGh? M{nrS2lEPTB;N{SuOlIhdk1? MXiyOFUyQTl7NR?=
CEM NYnCeoRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVu0PEBp Mn\UTWM2OD1{ND61OUBvVQ>? Mo\QNlQ2OTl7OUW=
P12 NXu1T4RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrYXVdsPDhiaB?= MlXhTWM2OD1zOD60OkBvVQ>? M4TvWFI1PTF7OUm1
NALM-16 NEP4eW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1WxfVQ5KGh? Mn7pTWM2OD14Mz6yOEBvVQ>? NYr5cnZEOjR3MUm5PVU>
JURKAT MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLDXW94PzJiaB?= MVvJR|UxRTNwNkWgcm0> MWqyOFUyQTl7NR?=
MOLT-4 NHfp[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnMeZM4OiCq MYLJR|UxRTdwM{mgcm0> MojONlQ2OTl7OUW=
REH Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv5XpM4OiCq M1HCb2lEPTB;MU[uNFEhdk1? M2rwSlI1PTF7OUm1
NALM-6 M1L5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjMUWk4OiCq MlnNTWM2OD1zLke4JI5O MW[yOFUyQTl7NR?=
RS 4;11 M4DXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPkRmJ1PzJiaB?= NGfkfItKSzVyPUSuN|ghdk1? NFLZe5AzPDVzOUm5OS=>
697 M2nHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnFcGIyPzJiaB?= MVLJR|UxRTd2LkK4JI5O NHP5dmwzPDVzOUm5OS=>
SIL-ALL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfG[oQ4OiCq Ml\XTWM2OD15LkKgcm0> MmfjNlQ2OTl7OUW=
CEM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWC3NkBp MkjBTWM2OD13LkSyJI5O MoLpNlQ2OTl7OUW=
P12 NH3L[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7xSpQ4OiCq Ml3UTWM2OD14LkO3JI5O MYKyOFUyQTl7NR?=
NALM-16 M3\1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXu3NkBp M2jJOGlEPTB;N{euO|Mhdk1? MXiyOFUyQTl7NR?=
Y79 MkP4RZBweHSxc3nzJGF{e2G7 NUDWdpFFOS13MDDuUS=> MV6xNk8zPCCq NH\O[YtFVVOR MVTpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= M1GwfFI1OzZ4Nk[1
WER-Rb-1 NHXI[YdCeG:ydH;zbZMhSXO|YYm= NXnXNJhWOS13MDDuUS=> M3\DTVEzNzJ2IHi= M{nzc2ROW09? MXvpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= MmHhNlQ{PjZ4NkW=
G7 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTNwMzDuUS=> M3zIRVI1OjB2N{Oz
G166 NIfVVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwMDDuUS=> M2e5RlI1OjB2N{Oz
CB660 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj2TWM2OD14LkSgcm0> NEjMOmIzPDJyNEezNy=>
CB1117 NUPxZWFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLuZ|ZKSzVyPUG1MlYhdk1? NHy1e2MzPDJyNEezNy=>
KB-3-1 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPZTGNKSzVyPUGuOFghyrFiMD61N{BvVQ>? M1u1eVI{QTZ{NES1
KB-8-5-11 M3izSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvuPGt1UUN3ME21MlAyKMLzIEKuNFEhdk1? MkT6NlM6PjJ2NEW=
KB-C-1 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y1[WlEPTB;MU[uO|YhyrFiND61NUBvVQ>? MoDONlM6PjJ2NEW=
KB-V-1 M4nxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT6b4FvUUN3ME2yPFEvOjRiwsGgN|EvPTdibl2= NH7QOZAzOzl4MkS0OS=>
OVCAR-8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLPemg2UUN3ME23MlE6KMLzIEOuOlAhdk1? MkjsNlM6PjJ2NEW=
NCI-ADR-RES NWfl[2VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z5fmlEPTB;MUK3N{4{OCEEsTCxPVEvOjBibl2= Mm[yNlM6PjJ2NEW=
MCF7 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13rO2lEPTB;NT6xNUDDuSBzLkS3JI5O NGnnWYYzOzl4MkS0OS=>
MCF7-FLV1000 M33KbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>? MnfLNlM6PjJ2NEW=
S1 NHjKUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HyO2lEPTB;MkSuN|AhyrFiND63OUBvVQ>? NXL5R2FwOjN7NkK0OFU>
S1-M1-80 NGXHNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULBXHZTUUN3ME2yOlEvODZiwsGgOFgvOjVibl2= M1y2fVI{QTZ{NES1
CORL-23/P NV;TblBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi0PHlVUUN3ME20MlM5KMLzIEGuNlUhdk1? M3;hflI{QTZ{NES1
CORL-23/R Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTVwMU[gxtEhOS56MzDuUS=> NGLSPZYzOzl4MkS0OS=>
NIH3T3 NVWwZ2F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\0TWM2OD12MD62NEDDuSB2Lkm3JI5O M3OzdFI{QTZ{NES1
NIH3T3-G185 NWDpfWxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P NYrXcY9POjN7NkK0OFU>
pcDNA-HEK293 NXHJXYRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PMTGlEPTB;Mj63OUDDuSByLk[3JI5O MmDMNlM6PjJ2NEW=
MDR19-HEK293 M17Idmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTh3LkWwJOKyKDF|Lk[3JI5O NVXMTFZsOjN7NkK0OFU>
R482-HEK293 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUKyUnRoUUN3ME2yOU46PyEEsTC0Mlk2KG6P Mo\zNlM6PjJ2NEW=
MRP1-HEK293 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfWeGJCUUN3ME2yMlk6KMLzIEGuOFkhdk1? MUmyN|k3OjR2NR?=
SF188 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PH[VExNTFyMDDuUS=> MonxNlQuQTZiaB?= NYjaXFFJTE2VTx?= NETsRoxqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK= M2D2elI{QDh5NkS1
T98G MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzRVoFFOTBvMUCwJI5O NYrQfWZMOjRvOU[gbC=> NEDzdY1FVVOR MnzYbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy NXfkXJBrOjN6OEe2OFU>
DU145 NIO5RXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq5SG1UVw>? NVXlNWZtUUN3MPMIwFYxKG6P NU\JeWd{OjN6OES0Nlg>
LNCaP  NUjOfVZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPNSG1UVw>? MnH4TWM2OOLKvEe1JI5O MW[yN|g5PDR{OB?=
PC3 NIH1XIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjRSG1UVw>? NXfNVZJ{UUN3MPMIwFE4PSCwTR?= M2XlZ|I{QDh2NEK4
RT4 NXWzSpRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1{Nz6yNUBvVQ>? NIPBNIMzOzd7Mk[zPS=>
5637 NVzpRoZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKxTWM2OD12NT60O{BvVQ>? NUS2WWdDOjN5OUK2N|k>
T24 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljTTWM2OD15OT6xNkBvVQ>? MknUNlM4QTJ4M{m=
MCF7  MnviSpVv[3Srb36gRZN{[Xl? NID1XVkyODBibl2= M3HNSFEhcA>? NWDm[Ig6TE2VTx?= NWjtRlM4emWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT|CpHNoczFuwrDQd|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?= MoTRNlM4PzB{NES=
KB-V1  MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjGUXRKSzVyPUOuPVIh|ryP MYeyN|U6OzF7Nh?=
Hec50co MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXQTWM2OD13IH7N MoG3NlMyPDZ4OEe=
MDA-MB-468 MlXIRZBweHSxc3nzJGF{e2G7 NIHrWXIyNzVxMUCgcm0> Ml\DNlQwPDhxN{KgbC=> Mom3SG1UVw>? Mn23bY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NFH3WHQzOzF2NEK5OC=>
MCF10A MVjBdI9xfG:|aYOgRZN{[Xl? M3HablEwPS9zMDDuUS=> NF7IZZYzPC92OD:3NkBp M3rCbGROW09? MX7pcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= MnW1NlMyPDR{OUS=
Huh-7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnyWZkyNzFyL{GwNE8yODByIH7N NVX2ZZdCPDhiaB?= Ml;3[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5 NI\hSoEzOjd2NUW4Oy=>
Daoy  MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK1R2cyNjh5NT2yOFAhdk1? NIToeVU4OiCq NYPHN3pSTE2VTx?= NHWxd3FKSzVyPUWgcm0> NGHU[4IzOjN7MEK3PS=>
ONS-76 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDaNU45PzVvMkSwJI5O MnXkO|IhcA>? MV3EUXNQ MmHaTWM2OD15LkWgcm0> MoP5NlI{QTB{N{m=
SUM 149 NVPBWFdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTTUG1MOC1zMECgcm0> M2rMWlczKGh? MnTzbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MlTpNlI{ODl7M{m=
MDA-MB-231 M{TSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3WwPFAuOTByIH7N NFzTdFQ4OiCq MnfwbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NWT4OY1QOjJ|MEm5N|k>
HR5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjaNE0yODBibl2= NEXncVg4OiCq NEXKPGJqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> Ml7sNlI{ODl7M{m=
BT-474-M1 NGnTPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHlc4QxNTFyMDDuUS=> MVW3NkBp MYXpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= MkHXNlI{ODl7M{m=
AU565 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLNPYQ2OC1zMECgcm0> M1zBXVczKGh? NXftWXRGcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NWDmTVZCOjJ|MEm5N|k>
T47D M13qUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnOV4RyOC1zMECgcm0> M37TWVczKGh? Ml\UbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MV[yNlMxQTl|OR?=
MCF7 NHXM[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6wMVExOCCwTR?= M1OzTlczKGh? NVPjXnlkcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz M2[3cFIzOzB7OUO5
HCT116p53(+/+) M1jkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XXe|ExNTFyMECgcm0> MkX4NlQwPDhiaB?= MkPibY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> NFnYO3QzOjJ4MkG3NS=>
HCT116p53(-/-) NVzHfoExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrLWHhpOTBvMUCwNEBvVQ>? NVX6NHJWOjRxNEigbC=> M3TCXYlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBkd22ybHX0[Yx6KGG2IEK1JI5O M4\MOVIzOjZ{MUex
HeLa  M{i2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXBNVAuOTByIH7N M4W0S|Q5KGh? MWjEUXNQ MkTOTWM2OD13Mj65JI5O M17rWFIzODhyMkO1
HeLa  NYPwdFVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLhNVAuOTByIH7N NV3ZN4RsPzJiaB?= M1:yPWROW09? M1Lic2lEPTB;NUCuOUBvVQ>? MmCxNlIxQDB{M{W=
GBC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTvN4dxPzJiaB?= Ml3UTWM2OD1zND63PEBvVQ>? NHnaPZozOTl4NUezPS=>
GB-CL-1 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nJO|czKGh? Ml3oTWM2OD13LkKyJI5O MkjENlE6PjV5M{m=
Mz-ChA-2 M3:1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\y[FczKGh? MUDJR|UxRTNwM{Ggcm0> MVuyNVk3PTd|OR?=
TGBC1-TKB M4jofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXUcZoyPDRiaB?= MUjJR|UxRTZwN{Kgcm0> M2PONVIyQTZ3N{O5
Wittier NGnhVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYO3NkBp MX\JR|UxRTNwMk[gcm0> MmDrNlE6PjV5M{m=
H-1 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK3NkBp MkTFTWM2OD17LkW0JI5O MmHtNlE6PjV5M{m=
HuH-28 NEjY[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF23T284OiCq NEHhRVFKSzVyPUGxMlE6KG6P NEPyeVEzOTl4NUezPS=>
NEC NVexRoJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrUbnl5PzJiaB?= NXnyeI02UUN3ME25Mlk5KG6P M3e2NFIyQTZ3N{O5
REB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\jS5k4OiCq NIOyfmZKSzVyPUGzMlUyKG6P NX7LdYlXOjF7NkW3N|k>
CC-LP-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHKN|liPzJiaB?= M{fQUWlEPTB;NT64OEBvVQ>? NXzvU4lnOjF7NkW3N|k>
CC-SW-1 NFu5T3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX6[pU4OiCq NH\5WGVKSzVyPUmuOVUhdk1? MViyNVk3PTd|OR?=
EGI-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y2R|czKGh? MV\JR|UxRTFyLkeyJI5O NHXrNFczOTl4NUezPS=>
Sk-ChA-1 M1\sUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDlO|IhcA>? MoP5TWM2OD1zNz6yJI5O NGfGSm8zOTl4NUezPS=>
TFK-1 NV7xbWZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm3NkBp MYHJR|UxRTF|LkS1JI5O MoTiNlE6PjV5M{m=
786-O M4r1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfGV2k2NThyIH7N NWXKPFU{QTZiaB?= MVvIR4w> NVnjeYVUe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N M1GzUFIyPjR{M{e0
A498 NUP6d|JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PQWlUuQDBibl2= MYi5OkBp MmWwTGNt MXPzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? MYSyNVY1OjN5NB?=
ACHN NUjQV5Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPqV2xuPS16MDDuUS=> Mn7yPVYhcA>? MYfIR4w> M2TOTZN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MljHNlE3PDJ|N{S=
Caki-1 NI\MO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLaOU05OCCwTR?= MWe5OkBp NFPibVFJS2x? NFqzR|R{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= NXO2UGlGOjF4NEKzO|Q>
SN12C MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7XOU05OCCwTR?= NYXlNmwxQTZiaB?= NETHSlhJS2x? MWPzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? M3jpW|IyPjR{M{e0
HMC-1.1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzlNU0yODByIH7N MXm3NkBp NVGyTW9qcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NYLWSoRkOjF{NEKxPFk>
HMC-1.2 NXTmTmF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqxMVExODBibl2= NVG0bm43PzJiaB?= M{HNcolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? MojONlEzPDJzOEm=
C2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2raNFEuOTByMDDuUS=> NXHJWmQ3PzJiaB?= MU\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MXyyNVI1OjF6OR?=
CHP-212 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xMVEzPSCwTR?= NIrN[3QzPC1zMkCgbC=> M4naVYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= Ml;GNlEyPjl{NEK=
IMR-32 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PjN|EuOTJ3IH7N NF\iN|IzPC1zMkCgbC=> NEDF[|lqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NWjMNVR3OjFzNkmyOFI>
Kelly MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v3elEuOTJ3IH7N NFqz[FAzPC1zMkCgbC=> NX\0Z45[cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MmnRNlEyPjl{NEK=
SH-EP MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYGxMVEzPSCwTR?= NEXub4czPC1zMkCgbC=> NYfKOIhtcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MWWyNVE3QTJ2Mh?=
SH-SY5Y MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxMVEzPSCwTR?= M1fI[VI1NTF{MDDo M4fFbIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NIrxcGkzOTF4OUK0Ni=>
SK-N-AS M3;1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXexMVEzPSCwTR?= M3jm[lI1NTF{MDDo NG\RW5dqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NYPjWHRXOjFzNkmyOFI>
SK-N-BE MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfINU0yOjVibl2= M4\1PVI1NTF{MDDo M1TPN4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= M{GxU|IyOTZ7MkSy
KG1 NGXte29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIflS4kyNzFyL{GwNEBvVQ>? MV63NkBp NFnvdW9FVVOR MVjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n Mkn2NVk1PTh|NUi=
U937 M{fj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLpNU8yOC9zMECgcm0> MYe3NkBp MmTUSG1UVw>? MX3pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n Ml3SNVk1PTh|NUi=
CAL62 NXTETlJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULKSGlpOC5zLUGwNEBvVQ>? MonqO|IhcA>? NFnYR5hFVVOR MlvZSWM2OD1zLkSgcm0> Mm\JNVkzOjN3NUO=
OCUT-1 NYLQfYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7wZ|RIOC5zLUGwNEBvVQ>? M{HRflczKGh? MYnEUXNQ M{XBSmVEPTB;Mj6zJI5O M1\ydlE6OjJ|NUWz
8505C M1TW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Cd497OC5zLUGwNEBvVQ>? NYnLS4VxPzJiaB?= NVy0bHZITE2VTx?= MnHUSWM2OD1|LkKgcm0> MXyxPVIzOzV3Mx?=
ACT-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELY[IUxNjFvMUCwJI5O MXe3NkBp MWnEUXNQ NHPaRWxGSzVyPUWuOEBvVQ>? MoW0NVkzOjN3NUO=
SW1736 NE\BeVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn4VHkxNjFvMUCwJI5O NF:3XnU4OiCq M4HYSGROW09? NVW4PVVQTUN3ME21MlYhdk1? MYGxPVIzOzV3Mx?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
- Collapse

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
- Collapse
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A
Smiles CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

Related PLK Products

Tags: buy BI 2536|BI 2536 ic50|BI 2536 price|BI 2536 cost|BI 2536 solubility dmso|BI 2536 purchase|BI 2536 manufacturer|BI 2536 research buy|BI 2536 order|BI 2536 mouse|BI 2536 chemical structure|BI 2536 mw|BI 2536 molecular weight|BI 2536 datasheet|BI 2536 supplier|BI 2536 in vitro|BI 2536 cell line|BI 2536 concentration|BI 2536 nmr|BI 2536 in vivo|BI 2536 clinical trial|BI 2536 inhibitor|BI 2536 Cell Cycle inhibitor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID