BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 102 Publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NVvnVYNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEC3O|Yh|ryP MmjUV2FPT0WU
ACN M4\MOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[4UnZKSzVyPUCuNFA5PDNizszN M1;iW3NCVkeHUh?=
TE-8 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLw[pVKSzVyPUCuNFA6PDFizszN MnH2V2FPT0WU
LC-2-ad MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEGwPVMh|ryP M2DFVnNCVkeHUh?=
ALL-PO MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEGzJO69VQ>? M1rYcXNCVkeHUh?=
EW-16 Ml\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3LUnhsUUN3ME2wMlAyOzN4IN88US=> M2HkfnNCVkeHUh?=
KM12 NFjRZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEGzOFgh|ryP MVHTRW5ITVJ?
GI-1 NEG0[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TPO2lEPTB;MD6wNVM5OyEQvF2= NWfTc2pEW0GQR1XS
LS-411N NHrlOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEG0NFch|ryP MUDTRW5ITVJ?
ES8 NXjlWmZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEG0PVQh|ryP MnHBV2FPT0WU
SNU-C2B MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrITWM2OD1yLkCxOVI3KM7:TR?= MnnhV2FPT0WU
CESS NIDscZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XjNWlEPTB;MD6wNVYxOiEQvF2= NWr0XVZ4W0GQR1XS
697 Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG5XnBKSzVyPUCuNFE3PjhizszN NXjnZXN3W0GQR1XS
NCI-H1963 NIDmTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f5UWlEPTB;MD6wNVY4OyEQvF2= NGWxSlhUSU6JRWK=
IA-LM NFntNWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6yXY9DUUN3ME2wMlAyPjh6IN88US=> MoexV2FPT0WU
SW954 NEHINFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvLTWM2OD1yLkCxO|A2KM7:TR?= MV3TRW5ITVJ?
RL95-2 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLLdFc3UUN3ME2wMlAyPzN6IN88US=> M2q0NXNCVkeHUh?=
LXF-289 NUjiTZA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLqSY5QUUN3ME2wMlAyPzdizszN MYXTRW5ITVJ?
OCUB-M NHT6fIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEG4NlYh|ryP NU\h[lNNW0GQR1XS
RKO Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fBbWlEPTB;MD6wNVk5PyEQvF2= MnT4V2FPT0WU
LOUCY NUXMc2ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv0TWM2OD1yLkCyNFUh|ryP NG\mNohUSU6JRWK=
NOS-1 NGK0d4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzueYFbUUN3ME2wMlAzODl|IN88US=> Ml7yV2FPT0WU
A4-Fuk MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEKyNVgh|ryP MVzTRW5ITVJ?
A388 NGm3ZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEKyNlch|ryP M3;1O3NCVkeHUh?=
TE-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHJN|ljUUN3ME2wMlAzOjZzIN88US=> NFLTXHZUSU6JRWK=
KURAMOCHI M37EVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmiyTWM2OD1yLkCyNlg2KM7:TR?= Mn3JV2FPT0WU
KALS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D4XGlEPTB;MD6wNlM{QCEQvF2= NFTtbmZUSU6JRWK=
HOP-62 NYrqNGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvP[HZKSzVyPUCuNFI1OiEQvF2= MVXTRW5ITVJ?
RPMI-8402 NHjZNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXUXodKSzVyPUCuNFI2ODhizszN M4PqeXNCVkeHUh?=
TE-1 NUn2cHZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37OZWlEPTB;MD6wNlUyOiEQvF2= NF\LW5dUSU6JRWK=
CCRF-CEM M1XWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEK1OFMh|ryP MXfTRW5ITVJ?
HUTU-80 NIjifIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf0TWM2OD1yLkCyOlI1KM7:TR?= MWTTRW5ITVJ?
NCI-H1648 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrUWFhuUUN3ME2wMlAzPjR5IN88US=> MmLKV2FPT0WU
HCE-4 NUnXZ5h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O5TGlEPTB;MD6wNlY5OiEQvF2= M1jtOXNCVkeHUh?=
ETK-1 NETqd|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TVT2lEPTB;MD6wNlc{PiEQvF2= MYPTRW5ITVJ?
TE-15 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mxWmlEPTB;MD6wNlc{QCEQvF2= MlzRV2FPT0WU
BE-13 M4rrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLaVWtvUUN3ME2wMlAzPzRizszN NGPIOWpUSU6JRWK=
KE-37 NUOwNIZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nEZWlEPTB;MD6wNlc1OSEQvF2= MmPiV2FPT0WU
NCI-H1355 M4f5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfNTWM2OD1yLkCyO|g{KM7:TR?= NFnIe2dUSU6JRWK=
TE-11 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXoTWM2OD1yLkCyPFA6KM7:TR?= Moj0V2FPT0WU
BL-70 MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorxTWM2OD1yLkCyPFU4KM7:TR?= NFTlW25USU6JRWK=
ES6 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[4TWM2OD1yLkCyPFgyKM7:TR?= NGjCbWlUSU6JRWK=
GT3TKB NHjMbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO4VXNKSzVyPUCuNFI6PTNizszN NHztWY5USU6JRWK=
LB647-SCLC NFfmW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLDToFKUUN3ME2wMlA{OTl3IN88US=> NFzMepJUSU6JRWK=
NB13 NXXxd3ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\FTWM2OD1yLkCzN|E3KM7:TR?= NYm2Ro1lW0GQR1XS
ST486 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofSTWM2OD1yLkCzN|M4KM7:TR?= NV;SSJdqW0GQR1XS
NCI-H82 M4PLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEOzOFMh|ryP MWnTRW5ITVJ?
NTERA-S-cl-D1 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFKw[I9KSzVyPUCuNFM{QTlizszN NFO3NVZUSU6JRWK=
ES4 NVTUTGpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHQU2xuUUN3ME2wMlA{PDZ|IN88US=> NXTMT29zW0GQR1XS
SK-NEP-1 NVPBOHRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG2W3dKSzVyPUCuNFM1QTlizszN MYjTRW5ITVJ?
Becker NHrFTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe1SI9SUUN3ME2wMlA{PTV3IN88US=> NVjyT5U4W0GQR1XS
A101D NVvTPZZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnQUGRKSzVyPUCuNFM4PDhizszN MXfTRW5ITVJ?
SK-UT-1 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\5cWlEPTB;MD6wN|c4PCEQvF2= NGLKR5dUSU6JRWK=
SW982 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nhW2lEPTB;MD6wN|c6KM7:TR?= MXzTRW5ITVJ?
TE-10 NIfifHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17q[GlEPTB;MD6wOFA1PiEQvF2= M37VNnNCVkeHUh?=
OVCAR-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3UfFBjUUN3ME2wMlA1ODV7IN88US=> M{[5U3NCVkeHUh?=
KP-N-YS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfFTWM2OD1yLkC0NFg2KM7:TR?= NHPEOIFUSU6JRWK=
BL-41 M4HsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMESxNlUh|ryP MnjFV2FPT0WU
MZ1-PC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3jRWJKSzVyPUCuNFQyOjdizszN MlG3V2FPT0WU
PF-382 NEHhfm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HkdWlEPTB;MD6wOFE6QCEQvF2= NHfq[JBUSU6JRWK=
MOLT-13 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz6NFgzUUN3ME2wMlA1OjN6IN88US=> NFnqRnlUSU6JRWK=
HCC1599 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Oy[WlEPTB;MD6wOFI2QCEQvF2= NVjJUIlTW0GQR1XS
IST-MEL1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMES0OFIh|ryP NVPrNoIxW0GQR1XS
LU-139 M3PkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMES0OFIh|ryP NH[wfY9USU6JRWK=
MS-1 NXzHPVlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIToPJRKSzVyPUCuNFQ4ODFizszN M1zHXHNCVkeHUh?=
MFH-ino NYjsNpVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj4eHRSUUN3ME2wMlA2ODB|IN88US=> M1y2[XNCVkeHUh?=
IMR-5 NWf1eHdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrQUW86UUN3ME2wMlA2ODJzIN88US=> MkHZV2FPT0WU
TE-5 MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjWTWM2OD1yLkC1NFY{KM7:TR?= MljtV2FPT0WU
DJM-1 NUjSNm91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XhbmlEPTB;MD6wOVE1OiEQvF2= M1\vfnNCVkeHUh?=
NB17 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljKTWM2OD1yLkC1NlA4KM7:TR?= MXfTRW5ITVJ?
KARPAS-45 NWXqb3o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEWzOVgh|ryP NYrmdnhjW0GQR1XS
TGBC1TKB MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWThbW0yUUN3ME2wMlA2PDB3IN88US=> M1ztXnNCVkeHUh?=
ML-2 NIexZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjjeXdKSzVyPUCuNFU1OTRizszN NYLXfZhvW0GQR1XS
no-10 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfWTWM2OD1yLkC1OFc1KM7:TR?= Mn7vV2FPT0WU
CTV-1 NHG5TpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;xTWM2OD1yLkC1OVAzKM7:TR?= M4jmfHNCVkeHUh?=
SJSA-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHxWpBKSzVyPUCuNFU2OiEQvF2= Mmq1V2FPT0WU
HC-1 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEW1PVch|ryP M3LiUHNCVkeHUh?=
TE-12 M4HlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX5TWM2OD1yLkC1OlE{KM7:TR?= NXnYeIxoW0GQR1XS
KY821 M3jP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;JfZZFUUN3ME2wMlA2PjN{IN88US=> NYH1[5duW0GQR1XS
TALL-1 NYrMcFNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO3R4ZKSzVyPUCuNFU4ODhizszN NXHnN4NwW0GQR1XS
DEL NGjBTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGKyXXVKSzVyPUCuNFU4ODlizszN NIDv[WhUSU6JRWK=
TE-6 NH;NV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEW3NlIh|ryP NHz3U4FUSU6JRWK=
SK-LMS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP3OmhTUUN3ME2wMlA2QDB3IN88US=> M3XRUXNCVkeHUh?=
EW-1 NVX5UoFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\qTWM2OD1yLkC1PFM4KM7:TR?= NUfWU5dsW0GQR1XS
8-MG-BA NF7a[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lpe2lEPTB;MD6wOVg2OSEQvF2= MWHTRW5ITVJ?
NALM-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPoTWM2OD1yLkC1PVc{KM7:TR?= MkjTV2FPT0WU
LB771-HNC M125O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HJfmlEPTB;MD6wOVk4QSEQvF2= MoroV2FPT0WU
HT-144 NF[xd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWwO5dOUUN3ME2wMlA3OTNizszN Mn;OV2FPT0WU
KM-H2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHPTWM2OD1yLkC2NlIyKM7:TR?= NEX4OFdUSU6JRWK=
SF268 NVO1WotJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnRfVRKSzVyPUCuNFYzQDZizszN M13MVHNCVkeHUh?=
RS4-11 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj1ZpFKSzVyPUCuNFY{ODRizszN Mmm3V2FPT0WU
MHH-PREB-1 NX3kfldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknGTWM2OD1yLkC2N|E6KM7:TR?= NWTGU5htW0GQR1XS
ATN-1 M1T1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTuTWM2OD1yLkC2N|Q2KM7:TR?= NEXZfGFUSU6JRWK=
BB30-HNC MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[0N|Yh|ryP NIL4bIdUSU6JRWK=
CPC-N MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTpTFBKSzVyPUCuNFY2OjRizszN M{S0UXNCVkeHUh?=
NB1 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrCN5pKSzVyPUCuNFY3OTNizszN NFfDbXNUSU6JRWK=
KS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwME[3OFgh|ryP NGm0NnpUSU6JRWK=
RXF393 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTMTWM2OD1yLkC2O|Y1KM7:TR?= M1P1SXNCVkeHUh?=
IST-SL2 NY\pNFB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;ZTWM2OD1yLkC3NFA1KM7:TR?= MWjTRW5ITVJ?
GI-ME-N M{XXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jvVGlEPTB;MD6wO|I5PiEQvF2= MYfTRW5ITVJ?
VA-ES-BJ NWixd3ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;STWlEPTB;MD6wO|Q4PSEQvF2= NWLJ[YJRW0GQR1XS
NCI-H1581 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLJTWM2OD1yLkC3OFc5KM7:TR?= Mm\SV2FPT0WU
U-266 NGfpco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLPTWM2OD1yLkC3OFk4KM7:TR?= MYLTRW5ITVJ?
DMS-114 NWPESJpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\WeWlEPTB;MD6wO|UzQCEQvF2= NXXTXFUyW0GQR1XS
NCI-H187 NG\zSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;3TWM2OD1yLkC3O|I3KM7:TR?= NYGyeWFzW0GQR1XS
SW962 NYK4cZp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjGR2JKSzVyPUCuNFc5OzlizszN NVPyUHNTW0GQR1XS
MONO-MAC-6 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEe5PFYh|ryP M3fHOHNCVkeHUh?=
MOLT-16 NX\FNGhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\FTWM2OD1yLkC4NVIyKM7:TR?= M{nmS3NCVkeHUh?=
KNS-42 NWjiV41tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fqbGlEPTB;MD6wPFE3OSEQvF2= NUHMTI9lW0GQR1XS
CMK NHTiNmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XRTmlEPTB;MD6wPFIzPSEQvF2= MX7TRW5ITVJ?
Ramos-2G6-4C10 NUftdldCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEiyNlUh|ryP NIXXV|JUSU6JRWK=
Daudi NWP3Tmx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljJTWM2OD1yLkC4NlU3KM7:TR?= MnnDV2FPT0WU
NCI-H510A M3PocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEizN|Yh|ryP NGjBXVBUSU6JRWK=
LB831-BLC M3LRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XkVWlEPTB;MD6wPFU3OSEQvF2= NGXQcHlUSU6JRWK=
HEL MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr6fJZKSzVyPUCuNFg3PjhizszN NVroRo42W0GQR1XS
LU-134-A M32zfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO5enlKSzVyPUCuNFg4ODhizszN MlXFV2FPT0WU
NCI-H1694 NHLB[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEi3OFQh|ryP MUPTRW5ITVJ?
KGN M3ryV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DXOGlEPTB;MD6wPFc2QSEQvF2= NIDCU3hUSU6JRWK=
A253 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fvbmlEPTB;MD6wPFgzOiEQvF2= M{jib3NCVkeHUh?=
DG-75 NVnIXoNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzuVHBxUUN3ME2wMlA5QTJ{IN88US=> NGnPNW1USU6JRWK=
MOLT-4 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLxTWM2OD1yLkC4PVg{KM7:TR?= NXLmV48yW0GQR1XS
NCI-SNU-5 M2jrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEmyOVgh|ryP NWT4cpZ{W0GQR1XS
ONS-76 M{O2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:0dGlEPTB;MD6wPVI4PiEQvF2= M1rpfHNCVkeHUh?=
NCI-H446 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX6SVJKSzVyPUCuNFk1PjJizszN MUjTRW5ITVJ?
COR-L279 M33wcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILlRmZKSzVyPUCuNFk2PTZizszN MVjTRW5ITVJ?
Calu-6 NH\0OXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXUUI9mUUN3ME2wMlA6PTl6IN88US=> NXPxeHBUW0GQR1XS
BC-3 M17FNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEm2OlIh|ryP MmnHV2FPT0WU
NCI-H2126 M13QNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEm3PVEh|ryP MWTTRW5ITVJ?
NCI-H1882 M3P4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\oTWM2OD1yLkC5PFA6KM7:TR?= Mnv6V2FPT0WU
BB65-RCC M4fhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7uVnlpUUN3ME2wMlExOjl2IN88US=> NYG1ZllQW0GQR1XS
DU-4475 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMUC0NFch|ryP MXPTRW5ITVJ?
NCI-H526 NXrNfodoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7XdGVKSzVyPUCuNVA1PCEQvF2= Mn\NV2FPT0WU
NEC8 M{Ho[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILaPIFKSzVyPUCuNVA2OjVizszN NXnZWZNyW0GQR1XS
NCI-H1304 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3TNmFKSzVyPUCuNVA2QTRizszN MUHTRW5ITVJ?
L-540 M1jZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ETWM2OD1yLkGwO|A5KM7:TR?= MYDTRW5ITVJ?
NCI-SNU-16 NYr3fGx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[2cI1KSzVyPUCuNVA4PDJizszN NYrFc216W0GQR1XS
HD-MY-Z NVy4NoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMUC4OVYh|ryP NVvVWnE2W0GQR1XS
K-562 NEnseXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrMfVNKSzVyPUCuNVA5PThizszN Mkm0V2FPT0WU
JAR NW\5SHpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HEN2lEPTB;MD6xNFkzPSEQvF2= NXXqdnFOW0GQR1XS
MZ2-MEL NFTwT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUGwOUDPxE1? NYnmT4VUW0GQR1XS
L-363 NGP2OoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2eyN2lEPTB;MD6xNVA4QSEQvF2= M{HZOnNCVkeHUh?=
BV-173 NWTUfJBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnUTGFKSzVyPUCuNVEzPDNizszN NXXuTVFkW0GQR1XS
NCI-H524 NWnSWINkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOyPW5KSzVyPUCuNVEzPzRizszN NILNRohUSU6JRWK=
EoL-1-cell MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rHOWlEPTB;MD6xNVY4OiEQvF2= MWrTRW5ITVJ?
K052 NILJRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\zNGlEPTB;MD6xNVcyOiEQvF2= M1;wZXNCVkeHUh?=
TK10 NVzTW4FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe1NY1XUUN3ME2wMlEyPzJ6IN88US=> M37ud3NCVkeHUh?=
KU812 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqyU5NKSzVyPUCuNVIxPDRizszN M1T2cnNCVkeHUh?=
RPMI-8226 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofGTWM2OD1yLkGyNFUzKM7:TR?= NF3tRWFUSU6JRWK=
MZ7-mel NGraXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLTWM2OD1yLkGyNlM4KM7:TR?= NYq5VGlWW0GQR1XS
SK-PN-DW M{\pR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom5TWM2OD1yLkGyNlg4KM7:TR?= NXLjS4dHW0GQR1XS
SR NXHDb5FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHZR5VKSzVyPUCuNVI1PDFizszN M37zN3NCVkeHUh?=
RPMI-6666 NYLENoFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6SGlEPTB;MD6xNlc1OyEQvF2= NV3z[JFDW0GQR1XS
no-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMUK4Olkh|ryP NX3jVodHW0GQR1XS
EW-3 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDQNHRKSzVyPUCuNVI5QTNizszN MWDTRW5ITVJ?
LAMA-84 NGXle2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fMZ2lEPTB;MD6xN|E5PyEQvF2= M1vRWnNCVkeHUh?=
HT MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMUO1O|Qh|ryP NEjDdFZUSU6JRWK=
KP-N-RT-BM-1 NHnHV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvVTWM2OD1yLkGzOlEzKM7:TR?= MkfzV2FPT0WU
NCI-H747 M{DheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHPTWM2OD1yLkGzO{DPxE1? M1rRfXNCVkeHUh?=
NCCIT MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISxdpdKSzVyPUCuNVM6OzlizszN NUP5NlVFW0GQR1XS
MLMA MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jHOmlEPTB;MD6xOFE3PyEQvF2= Mo\iV2FPT0WU
LP-1 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonETWM2OD1yLkG0NlQh|ryP NEHKVmNUSU6JRWK=
CAL-148 NIP5SFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rZ[GlEPTB;MD6xOFQ5OyEQvF2= MmO5V2FPT0WU
GB-1 NIjKcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf4PFJKSzVyPUCuNVQ2OjZizszN MV3TRW5ITVJ?
COR-L88 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3GTWM2OD1yLkG0PFAzKM7:TR?= NYHMbnI{W0GQR1XS
NKM-1 M4fUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\LR5pKSzVyPUCuNVQ6ODZizszN MVrTRW5ITVJ?
NB5 NInDN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmToTWM2OD1yLkG1OFYzKM7:TR?= M3rP[3NCVkeHUh?=
SH-4 M3r5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjUcHFNUUN3ME2wMlE2PDZ4IN88US=> NYrtWZpyW0GQR1XS
EM-2 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXZUo5KSzVyPUCuNVU1PjdizszN Mnr6V2FPT0WU
TGBC24TKB NFrzN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnrRVJKSzVyPUCuNVU3PTlizszN NHXmPJNUSU6JRWK=
SCLC-21H MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMUW3NFIh|ryP NVLRW41ZW0GQR1XS
COLO-684 NXH4XYdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPVTWM2OD1yLkG1O|IyKM7:TR?= M33SWnNCVkeHUh?=
KINGS-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTiTWM2OD1yLkG1PVEh|ryP M2jjRnNCVkeHUh?=
LS-123 NHmwTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XVRmlEPTB;MD6xOVkyPyEQvF2= NFO2bFZUSU6JRWK=
MC116 NU\vTGNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHO0UZVKSzVyPUCuNVYyPThizszN NHz2OIZUSU6JRWK=
SU-DHL-1 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPrOYl6UUN3ME2wMlE3OjB4IN88US=> NXzRUlJ1W0GQR1XS
NCI-H64 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMU[zOFch|ryP M4TGfnNCVkeHUh?=
HCE-T NIrVcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMU[1NFQh|ryP NFXocG5USU6JRWK=
LOXIMVI NHXLbIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HEXmlEPTB;MD6xOlk1QSEQvF2= Ml30V2FPT0WU
ARH-77 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInaO|JKSzVyPUCuNVc{PzlizszN MorzV2FPT0WU
DOHH-2 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLBd5FrUUN3ME2wMlE4Pjd{IN88US=> M{LBNXNCVkeHUh?=
COLO-320-HSR NYfnRo53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUixOVQh|ryP M{TDfXNCVkeHUh?=
NB6 NVfzNFVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[zTWM2OD1yLkG4OVY3KM7:TR?= M4rWVXNCVkeHUh?=
L-428 M3\C[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPNVVhtUUN3ME2wMlE5QDF|IN88US=> Mo\1V2FPT0WU
SNB75 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUi4NlQh|ryP M{DUb3NCVkeHUh?=
NCI-H2141 NYWzdpcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknFTWM2OD1yLkG5NFEyKM7:TR?= NYnEN3hEW0GQR1XS
KARPAS-299 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL4cFlKSzVyPUCuNVkzPDFizszN M3XibHNCVkeHUh?=
LC4-1 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HucGlEPTB;MD6xPVUxOiEQvF2= MnrEV2FPT0WU
UACC-257 NF7RNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMUm5OFch|ryP MlvTV2FPT0WU
EVSA-T M2PPd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrwTWM2OD1yLkKwN|EzKM7:TR?= MmPIV2FPT0WU
JiyoyeP-2003 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7PTWM2OD1yLkKwOFc4KM7:TR?= MoDjV2FPT0WU
NCI-H720 M4\4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn30TWM2OD1yLkKwOVI2KM7:TR?= MlGwV2FPT0WU
GAK M1jDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnixTWM2OD1yLkKxNVg6KM7:TR?= MkDzV2FPT0WU
HH MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i4W2lEPTB;MD6yNVQxPSEQvF2= NGfZUJlUSU6JRWK=
NCI-H1436 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\4VWlEPTB;MD6yNVQ3PCEQvF2= NX;XeHlsW0GQR1XS
GR-ST M4nJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMkG0PFgh|ryP M{T4RnNCVkeHUh?=
BC-1 NWHtW4xJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33ZfGlEPTB;MD6yNlYyPiEQvF2= NXrLOldjW0GQR1XS
SIG-M5 NGLXNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfXTWM2OD1yLkKyO|I4KM7:TR?= Mo\uV2FPT0WU
NCI-H345 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqxSGFKSzVyPUCuNlM5ODVizszN NWeyPYVzW0GQR1XS
OPM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHOwcI1KSzVyPUCuNlM5QDJizszN NWLkbHV2W0GQR1XS
LB1047-RCC M3nQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHNVpNKSzVyPUCuNlQ1OSEQvF2= MV\TRW5ITVJ?
CTB-1 M2nCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMkS0PVMh|ryP MVrTRW5ITVJ?
A3-KAW MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjuR2lKSzVyPUCuNlU{PDFizszN MYHTRW5ITVJ?
SF126 NEf2ZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMkWzPFMh|ryP MX;TRW5ITVJ?
KARPAS-422 NF31WYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMkW0N|Uh|ryP MkPoV2FPT0WU
MEG-01 NGnkWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7mTmZQUUN3ME2wMlI2Pjd|IN88US=> Mn3pV2FPT0WU
NCI-H209 M1LueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTBU48yUUN3ME2wMlI3Ozd2IN88US=> NH;vOGFUSU6JRWK=
SBC-1 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXuT|dXUUN3ME2wMlI3PSEQvF2= NWHEe29rW0GQR1XS
K5 NHPOWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELLZmJKSzVyPUCuNlY6QDRizszN NVPjdodVW0GQR1XS
QIMR-WIL NVnqO5FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HsRWlEPTB;MD6yO|E2PSEQvF2= NILKfZhUSU6JRWK=
NMC-G1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TFW2lEPTB;MD6yPFIyPyEQvF2= M2DYeHNCVkeHUh?=
IST-MES1 NEe3PZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL4TWM2OD1yLkK5NlM5KM7:TR?= NXfifFNNW0GQR1XS
SW684 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH0fVhKSzVyPUCuN|AxPDdizszN NWfzT2RkW0GQR1XS
MV-4-11 NF;JNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwM{C3PFgh|ryP MUHTRW5ITVJ?
LAN-6 NVLLV|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwM{G1O|Ih|ryP MkK5V2FPT0WU
RH-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jv[GlEPTB;MD6zNVg4OSEQvF2= NWTH[WR1W0GQR1XS
CP66-MEL NHS2bGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XPO2lEPTB;MD6zNVg4QCEQvF2= MVzTRW5ITVJ?
EC-GI-10 NWDrSoRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwM{K5PFch|ryP NVTpNYduW0GQR1XS
GDM-1 Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwM{OwOVkh|ryP MWfTRW5ITVJ?
IST-SL1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLaTWM2OD1yLkO0PVE1KM7:TR?= M2\GT3NCVkeHUh?=
KMOE-2 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq4N2ZbUUN3ME2wMlM2OTd3IN88US=> NFT0S4FUSU6JRWK=
OS-RC-2 NFLL[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHToW3hKSzVyPUCuN|U2PDRizszN NF3EXXNUSU6JRWK=
HDLM-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2xeHJKSzVyPUCuN|c5OTRizszN MYHTRW5ITVJ?
DSH1 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDadGFKSzVyPUCuN|g3OzFizszN NYn6SpdVW0GQR1XS
LS-1034 Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HCfmlEPTB;MD6zPFk2PCEQvF2= MUTTRW5ITVJ?
LB373-MEL-D MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\uTGlEPTB;MD6zPVE6PyEQvF2= MYXTRW5ITVJ?
GOTO NETPc4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPFTWM2OD1yLkSyNVE5KM7:TR?= NWX5OIZPW0GQR1XS
MRK-nu-1 M2HVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C2c2lEPTB;MD60NlIxPSEQvF2= NGrseG1USU6JRWK=
SK-MM-2 M124XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7Dd4RYUUN3ME2wMlQ{PDR{IN88US=> MUfTRW5ITVJ?
BOKU NYPtT4FYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfa[G9KSzVyPUCuOFM4QTJizszN NHrr[|BUSU6JRWK=
NOMO-1 Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HCc2lEPTB;MD60N|g3KM7:TR?= MlK2V2FPT0WU
J-RT3-T3-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwNES4O|gh|ryP MnvEV2FPT0WU
COLO-668 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwNEW2Olgh|ryP MX;TRW5ITVJ?
SF539 M{LtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNEi2PFQh|ryP NIi5TXFUSU6JRWK=
LB2518-MEL M4XzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjVS4dKSzVyPUCuOFk4ODNizszN M37F[3NCVkeHUh?=
TE-441-T MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNUCxNkDPxE1? MonKV2FPT0WU
MDA-MB-134-VI MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq3TWM2OD1yLkWwPVIyKM7:TR?= MkH2V2FPT0WU
SCC-3 M2jIPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFXWlEPTB;MD61NVg4OyEQvF2= MVjTRW5ITVJ?
KLE NG\mbZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTFNmNKSzVyPUCuOVIyPzFizszN NUHPPZFYW0GQR1XS
LB2241-RCC NIHRV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG0d|l5UUN3ME2wMlUzPTJ3IN88US=> MVfTRW5ITVJ?
NCI-H1417 NIPZTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwNUO0N|Uh|ryP M4jJV3NCVkeHUh?=
NCI-H2081 NFHyfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwNUi2NVEh|ryP M2DVZXNCVkeHUh?=
NCI-H1522 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwNUmzPFMh|ryP NXrKbnREW0GQR1XS
NCI-H889 NGLHfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHjTWM2OD1yLkW5PFQ1KM7:TR?= NXziSolUW0GQR1XS
CGTH-W-1 M4TXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULoU5dCUUN3ME2wMlYxPzV3IN88US=> NILrepdUSU6JRWK=
EB-3 NI\YXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNkGxOVMh|ryP NW\xN|c3W0GQR1XS
D-336MG M2m2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmezTWM2OD1yLk[xO|kyKM7:TR?= M4eySHNCVkeHUh?=
LC-1F Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNkK1PVIh|ryP Mn3QV2FPT0WU
MHH-NB-11 NIOweHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWezXWFLUUN3ME2wMlY{QDBzIN88US=> MYPTRW5ITVJ?
SK-N-FI NWTsV2p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwNkO5NUDPxE1? MULTRW5ITVJ?
NCI-H69 NYfjXJZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS3fmU4UUN3ME2wMlY1QDd7IN88US=> NETKS4VUSU6JRWK=
SCH NF2xNpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVroXIFrUUN3ME2wMlY3ODJ|IN88US=> M{TifnNCVkeHUh?=
LS-513 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XGbmlEPTB;MD62O|I2QSEQvF2= NV\vO|dKW0GQR1XS
CP67-MEL NEPNcFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rSd2lEPTB;MD62O|U6PiEQvF2= M4C0V3NCVkeHUh?=
GCIY MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwN{CzOlMh|ryP NH3ad|BUSU6JRWK=
SHP-77 M3SyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPmNGRKSzVyPUCuO|A4OzRizszN NXf6Olc6W0GQR1XS
EHEB NIjmSoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnVRXRuUUN3ME2wMlcyQDV2IN88US=> MkfyV2FPT0WU
D-247MG NGnWR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\tTmlEPTB;MD63N|I{OiEQvF2= M3zWOHNCVkeHUh?=
Raji NX3KcY1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK5XYVqUUN3ME2wMlc1QTh7IN88US=> MWDTRW5ITVJ?
MPP-89 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjXdY9KSzVyPUCuO|U6PzhizszN MUfTRW5ITVJ?
EKVX NWPDUIhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\0V4hKSzVyPUCuO|kxPzNizszN NY\udoxGW0GQR1XS
HCC2218 NXzyU3F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn4fopKSzVyPUCuO|kyOzFizszN M4riUnNCVkeHUh?=
KNS-81-FD MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXlTWM2OD1yLkixNFEyKM7:TR?= NXn6ZmVJW0GQR1XS
HCC2157 NH\MV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XxeGlEPTB;MD64OFk2OSEQvF2= M13ScHNCVkeHUh?=
BT-474 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTo[od1UUN3ME2wMlg5QDV2IN88US=> MornV2FPT0WU
NCI-H748 M2rFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXUbWlKSzVyPUCuPVEzKM7:TR?= MUXTRW5ITVJ?
EW-24 M37BNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPiXI53UUN3ME2wMlkzODB{IN88US=> NWPJW3dJW0GQR1XS
D-263MG MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH21RZpKSzVyPUCuPVQ2OTJizszN NFO4O|hUSU6JRWK=
OMC-1 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXXTWM2OD1yLkm2N|c{KM7:TR?= NGrQNZZUSU6JRWK=
NCI-H2196 NInaNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jpU2lEPTB;MD65O|c4PyEQvF2= NWDOe3BRW0GQR1XS
HAL-01 M2XYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwOUm4O|Ih|ryP NETJSXNUSU6JRWK=
NCI-H2107 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PwV2lEPTB;MT6wNVg2PCEQvF2= NV3ndYpRW0GQR1XS
LB996-RCC MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPwZ3hKSzVyPUGuNFgxPTFizszN MWPTRW5ITVJ?
NCI-H1395 M1\ucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPCTWM2OD1zLkGwOlch|ryP MoT0V2FPT0WU
CHP-126 NEP2emhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonpTWM2OD1zLkG2NVk6KM7:TR?= NY\1Z|U6W0GQR1XS
NB69 NYG1Top4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnYR|RKSzVyPUGuNlYyPDhizszN M2DDc3NCVkeHUh?=
CAS-1 NFnFb|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDETWM2OD1zLkO0NlMyKM7:TR?= MUTTRW5ITVJ?
JVM-3 NGrXb41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XsSmlEPTB;MT60O|g2PSEQvF2= NFS5OIxUSU6JRWK=
DMS-153 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr4TWM2OD1zLkW3Olc1KM7:TR?= NWnuXGxJW0GQR1XS
SK-MEL-2 NYq5VWh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPrToNKSzVyPUGuO|E4QDlizszN NXOxU484W0GQR1XS
NCI-H1155 NVq1W3pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwN{O2O|Yh|ryP NWrwWoUyW0GQR1XS
NCI-H1092 NYfEUJFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDpfINKSzVyPUGuO|YyQDJizszN MVfTRW5ITVJ?
LU-165 NIi5WHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK5dWZKSzVyPUGuPFY1PzZizszN Mo\DV2FPT0WU
HL-60 NV2yUpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPMTWM2OD1zLkm5PVA5KM7:TR?= NYDZW|FxW0GQR1XS
REH M37mN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3EcG9KSzVyPUKuNFA2QDJizszN M4HNSnNCVkeHUh?=
JVM-2 NXHWUY1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7IXFdKSzVyPUKuNFYyOzVizszN MlL2V2FPT0WU
MN-60 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPQTWM2OD1{LkG3N|A5KM7:TR?= NF;HTVlUSU6JRWK=
SCC-15 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkKzTWM2OD1{LkKwNlch|ryP M{TGXXNCVkeHUh?=
SNU-C1 NGrnc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jx[GlEPTB;Mj6yNVM1OyEQvF2= MlTDV2FPT0WU
SK-MEL-1 NVriV5E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ruOGlEPTB;Mj6zNlA1PyEQvF2= MlzOV2FPT0WU
TGW MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwM{WwNlch|ryP M2XZWnNCVkeHUh?=
CA46 NFvDWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwN{W5Olch|ryP MljjV2FPT0WU
NCI-H23 NVi0eGdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJwOEC3PVEh|ryP MoDIV2FPT0WU
MMAC-SF NHnISpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwOE[2Nlgh|ryP MUDTRW5ITVJ?
NCI-H2171 M1i5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\nTWM2OD1|LkCzOFQ5KM7:TR?= NGDaWFRUSU6JRWK=
A704 NGr3bYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPvNmpKSzVyPUOuNVQyQTRizszN MoHWV2FPT0WU
DB NV3SbGtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNwMkW1O|Yh|ryP MXLTRW5ITVJ?
NCI-H719 NYLOZWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;WPFdJUUN3ME2zMlMxOzh2IN88US=> NVPZNIJ1W0GQR1XS
MC-CAR MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zGN2lEPTB;Mz61OFgyPyEQvF2= NUDhNoQ6W0GQR1XS
SIMA NFrsTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqyRW8yUUN3ME2zMlU5PDF4IN88US=> NH;aW|NUSU6JRWK=
SW872 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTNwN{ixNFEh|ryP NWLNd3g1W0GQR1XS
HCC1187 M3XhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwN{izNVUh|ryP M1uwZ3NCVkeHUh?=
EW-13 MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXvbVFKSzVyPUOuPFM1OTdizszN M3njS3NCVkeHUh?=
NCI-SNU-1 M1u2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XZXWlEPTB;ND6yNVk6QSEQvF2= MX7TRW5ITVJ?
NCI-H226 NXj1dIpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGweYpVUUN3ME20MlM{PjB4IN88US=> MkXmV2FPT0WU
RPMI-8866 M1zZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTRwM{[wNlkh|ryP NVzuWG1JW0GQR1XS
OCI-AML2 NX3R[5BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;CUGdJUUN3ME20MlU2OjNizszN NY\3Zos3W0GQR1XS
LU-65 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf2T402UUN3ME20Mlk{ODN|IN88US=> M1L0OXNCVkeHUh?=
SK-N-DZ M{Hvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW2c2RbUUN3ME21MlY{PDZ3IN88US=> MoDYV2FPT0WU
NB14 MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjuSFdKSzVyPUWuPVcyOzVizszN M{TQZXNCVkeHUh?=
COLO-829 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL0TWM2OD14LkOzN|U6KM7:TR?= NGHCdWhUSU6JRWK=
MHH-CALL-2 M2PNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTZwNUG1NFgh|ryP MmrjV2FPT0WU
NCI-H1770 NFPv[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZwNk[5NFQh|ryP NITYSppUSU6JRWK=
ECC4 NVO1ZphRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DadWlEPTB;Nj64NlE4QSEQvF2= MVjTRW5ITVJ?
A498 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e2fmlEPTB;Nj64O|E6OiEQvF2= MYnTRW5ITVJ?
DMS-79 NV\BXpdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTdwMES1NVIh|ryP NIKyZWVUSU6JRWK=
P30-OHK NXy2Z5A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfvZ4pKSzVyPUeuNlE6ODZizszN NVvnUYhRW0GQR1XS
D-502MG M1;3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnDV5hKSzVyPUeuPVg{PiEQvF2= NX;weJl5W0GQR1XS
RCC10RGB NFHNcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfPUlRRUUN3ME24MlA3OjhizszN MlXwV2FPT0WU
U-698-M M3;oUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTLW2x2UUN3ME24MlI6OjJ4IN88US=> NYW4VHdMW0GQR1XS
BB49-HNC NITFbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTlwNEKyOlUh|ryP M37PSnNCVkeHUh?=
ES1 NEPNOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTlwNki5OVYh|ryP MojqV2FPT0WU
MFM-223 NIDVTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFyLkm5Nlch|ryP NETBO29USU6JRWK=
C2BBe1 M3Pybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XncmlEPTB;MUGuN|UzOyEQvF2= NGTTPVdUSU6JRWK=
EB2 NFf6T2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTF{Lk[4PFEh|ryP NYf4UnNVW0GQR1XS
C8166 M{K2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnZNG1UUUN3ME2xN{45OzB|IN88US=> NG\6OoNUSU6JRWK=
ES3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLGTWM2OD1zMz65PVc4KM7:TR?= NWLGb5RmW0GQR1XS
NCI-H1650 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jDRmlEPTB;MU[uN|c3PSEQvF2= M2nxenNCVkeHUh?=
Mo-T NEnleGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\JTWM2OD1zNz60NFI6KM7:TR?= NV3pSZNxW0GQR1XS
NB7 M1PncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrKPZllUUN3ME2xO{44PDZ5IN88US=> Mmj3V2FPT0WU
ES7 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljsTWM2OD1zOT61OVA4KM7:TR?= M33aNHNCVkeHUh?=
ES5 NFHkT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljyTWM2OD1{MT63OlcyKM7:TR?= M4DJbXNCVkeHUh?=
MSTO-211H MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\GSHdKSzVyPUKxMlg5PThizszN M3e4RnNCVkeHUh?=
U-87-MG NXy3d4NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi3T|ZKSzVyPUK1MlE6PjZizszN MUXTRW5ITVJ?
THP-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[yZlVwUUN3ME2yPU44OjBzIN88US=> MkTUV2FPT0WU
NB10 M1Xqc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTNyLkK2PVQh|ryP MoDRV2FPT0WU
NH-12 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfENYZKSzVyPUOzMlIxOTdizszN MYPTRW5ITVJ?
COLO-824 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELDXHJKSzVyPUO0MlExODZizszN MYDTRW5ITVJ?
SKM-1 NXzSc|loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn2eY5KSzVyPUO3Mlg1OjJizszN MlXxV2FPT0WU
NCI-H1838 NHvBWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjnZ2pKSzVyPUO4MlM4QTdizszN MWPTRW5ITVJ?
RL NWf0OZQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzXV5g5UUN3ME2zPU4zPDd5IN88US=> MlnkV2FPT0WU
COLO-800 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3QR41SUUN3ME20NE4xPzd|IN88US=> NVXCN|I5W0GQR1XS
KG-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zRSGlEPTB;NECuPFk2PSEQvF2= MV;TRW5ITVJ?
TUR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj5TWM2OD12MT62N|k6KM7:TR?= NULBPWRQW0GQR1XS
LNCaP-Clone-FGC NVvod2ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3rTWM2OD12MT65NFE4KM7:TR?= NXy4NFBjW0GQR1XS
NCI-H322M NUHwb|JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17wdGlEPTB;NEKuOVk5PCEQvF2= MX;TRW5ITVJ?
LNCaP  NWLMSmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvrW2NKSzVyPUmxMlMhdk1? MYGyOVUxPTF5NB?=
C4-2 NIS3XXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRThibl2= MUOyOVUxPTF5NB?=
JURKAT MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLs[4YzPCCq MV\JR|UxRTRzNj62OkBvVQ>? MlvWNlQ2OTl7OUW=
MOLT-4 M3ezb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm1NlQhcA>? NHzONllKSzVyPUK4OVMvPSCwTR?= MmC4NlQ2OTl7OUW=
REH MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TKWVI1KGh? NV;BSWFwUUN3ME2yPFcvPjhibl2= Mlj0NlQ2OTl7OUW=
NALM-6 NVe2cFVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K2eVI1KGh? NGXu[HVKSzVyPUO0N|MxKG6P NXTtS4M5OjR3MUm5PVU>
RS 4;11 NV\1NVhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjxeVIzPCCq MXLJR|UxRTVzOT6wOUBvVQ>? NXPkbodOOjR3MUm5PVU>
697 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjIcGYzPCCq MXrJR|UxRTJzMEeuNUBvVQ>? MVSyOFUyQTl7NR?=
SIL-ALL NHzBS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH75N5EzPCCq NHnXfWlKSzVyPUG5PU44PyCwTR?= MnjVNlQ2OTl7OUW=
CEM NVS5c3lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXWyOEBp M4DkSGlEPTB;NUKuNVghdk1? MXOyOFUyQTl7NR?=
P12 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jmNVI1KGh? M3v5WGlEPTB;M{muNlchdk1? MXeyOFUyQTl7NR?=
NALM-16 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHLTYh5OjRiaB?= M{DtfmlEPTB;OU[uNlghdk1? MkLLNlQ2OTl7OUW=
JURKAT NHLudXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLWS5FqPDhiaB?= Mn;GTWM2OD1zND64OEBvVQ>? M2\PbVI1PTF7OUm1
MOLT-4 NV;ONoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX60PEBp NUe5VYR3UUN3ME2yOk43KG6P NYD0XG12OjR3MUm5PVU>
REH MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HpcFQ5KGh? M3riTGlEPTB;NESuO|Ehdk1? NIizZ4YzPDVzOUm5OS=>
NALM-6 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPVc2tyPDhiaB?= NEm2bmlKSzVyPUKzMlI3KG6P MomyNlQ2OTl7OUW=
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HMC-1.2 M{OxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYGxMVExODBibl2= NV\oSohGPzJiaB?= MXnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NFTaXmMzOTJ2MkG4PS=>
C2 M3npbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX74TmRyOS1zMECwJI5O M3XmbFczKGh? NGrjU5lqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? NHnmWHozOTJ2MkG4PS=>
CHP-212 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPjZYF4OS1zMkWgcm0> NWjpeGpSOjRvMUKwJIg> MkfjbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NIrYSpkzOTF4OUK0Ni=>
IMR-32 NX\EfIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILa[pQyNTF{NTDuUS=> MlT3NlQuOTJyIHi= MWnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M1fkcFIyOTZ7MkSy
Kelly M17CNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\WSHMyNTF{NTDuUS=> MUKyOE0yOjBiaB?= MlzmbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= M1TxSVIyOTZ7MkSy
SH-EP NVvaelJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrnW4gyNTF{NTDuUS=> MnjHNlQuOTJyIHi= NUfkXZJHcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NWX2dFRkOjFzNkmyOFI>
SH-SY5Y MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrONU0yOjVibl2= MmXmNlQuOTJyIHi= NHrUWWdqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NF7GTZIzOTF4OUK0Ni=>
SK-N-AS MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXKxMVEzPSCwTR?= NVLNbHJ{OjRvMUKwJIg> NIewfnFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M4DE[VIyOTZ7MkSy
SK-N-BE NVzxOYZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[2fI5iOS1zMkWgcm0> M16yOlI1NTF{MDDo NUfWNHNjcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M1zv[|IyOTZ7MkSy
KG1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnVXHJSOS9zMD:xNFAhdk1? NFq3Z4k4OiCq NYnuRZgzTE2VTx?= MW\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MlrRNVk1PTh|NUi=
U937 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n1VFEwOTBxMUCwJI5O MUe3NkBp MWTEUXNQ NWXF[JJkcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M12zcFE6PDV6M{W4
CAL62 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjaZYNJOC5zLUGwNEBvVQ>? M4XoO|czKGh? NIq0PVBFVVOR NHLzNZFGSzVyPUGuOEBvVQ>? Mk\KNVkzOjN3NUO=
OCUT-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPkNE4yNTFyMDDuUS=> NYPGTHR5PzJiaB?= MV\EUXNQ NGTQVlZGSzVyPUKuN{BvVQ>? MmL4NVkzOjN3NUO=
8505C MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXOVJlZOC5zLUGwNEBvVQ>? MlvMO|IhcA>? NWfKdWM2TE2VTx?= NIr4O|dGSzVyPUOuNkBvVQ>? MmTVNVkzOjN3NUO=
ACT-1 NEDOUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DGTlAvOS1zMECgcm0> MkG5O|IhcA>? NV;Mb2l2TE2VTx?= Mo\lSWM2OD13LkSgcm0> MUCxPVIzOzV3Mx?=
SW1736 NEPTdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj1NE4yNTFyMDDuUS=> MnfVO|IhcA>? NIDa[HFFVVOR Mn6zSWM2OD13Lk[gcm0> M1jTZ|E6OjJ|NUWz

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID