BI 2536

Name: BI 2536
Brand: Selleck Chemicals
SKU: S1109
Rating: 5 (235 reviews)

For research use only.

Catalog No.S1109

235 publications

CAS No. 755038-02-9

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

Selleck's BI 2536 has been cited by 235 publications

Cancer Cell, 2020, 37(3):340-353

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Science, 2019, 364(6447)

PubMed: 31249032 ( click the link to review the publication )

Cancer Cell, 2019, 36(2):179-193

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Cell, 2019, 36(2):179-193

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Nature, 2017, 548(7668):466-470

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Science, 2015, 13;347(6227):aaa2630.

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Cancer Discov, 2014, 4(11):1281-9

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Cell, 2011, 11;147(4):853-67.

PubMed: 22078882 ( click the link to review the publication )

Cancer Cell, 2010, 18(6):641-54

PubMed: 21156286 ( click the link to review the publication )

Cancer Res, 2021, canres.2276.2020

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Cell Rep, 2021, 34(9):108805

PubMed: 33657383 ( click the link to review the publication )

Cancers (Basel), 2021, 13(6)1205

PubMed: 33801977 ( click the link to review the publication )

J Cell Sci, 2021, 134(1)jcs251025

PubMed: 33288550 ( click the link to review the publication )

Breast Cancer, 2021, 10.1007/s12282-021-01242-z

PubMed: 33813687 ( click the link to review the publication )

Elife, 2021, 10e62640

PubMed: 33491649 ( click the link to review the publication )

Commun Biol, 2021, 4(1):358

PubMed: 33742057 ( click the link to review the publication )

STAR Protoc, 2021, 2(1):100293

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EMBO Rep, 2021, e51030

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Mol Cell, 2020, S1097-2765(20)30774-7

PubMed: 33248027 ( click the link to review the publication )

Mol Cell, 2020, 10.1016/j.molcel.2020.01.023

PubMed: 32035037 ( click the link to review the publication )

Nat Commun, 2020, 29;11(1):2086

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Nat Commun, 2020, 14;11(1):1819

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Autophagy, 2020, 1-17

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J Cell Biol, 2020, 219(11)e201910148

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J Cell Biol, 2020, 1;219(6):e201910019

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Cell Rep, 2020, 32(9):108080

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Cell Rep, 2020, 17;30(11):3605-3615.e5

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Cell Death Differ, 2020, 19

PubMed: 32203171 ( click the link to review the publication )

Oncogene, 2020, 39(15):3145-3162

PubMed: 32060423 ( click the link to review the publication )

Cancers (Basel), 2020, 12(9)E2498

PubMed: 32899210 ( click the link to review the publication )

Cells, 2020, 9(9)E2126

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Cell Chem Biol, 2020, 27(3):350-362

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Curr Biol, 2020, 30(22):4519-4527.e3

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ACS Chem Biol, 2020, 20;15(3):669-674

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J Cell Sci, 2020, 2;jcs.244442

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Biochem Biophys Res Commun, 2020, 521(4):833-839

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DNA Cell Biol, 2020, 10.1089/dna.2019.5002

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Antivir Ther, 2020, 25(3):151-162

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Front Vet Sci, 2020, 7:611270

PubMed: 33409299 ( click the link to review the publication )

Cell Death Differ, 2020, 10.1038

PubMed: 32015503 ( click the link to review the publication )

Sci Rep, 2020, 10(1):12327

PubMed: 32704044 ( click the link to review the publication )

Cells, 2020, 9(1)

PubMed: 31947732 ( click the link to review the publication )

J Cancer, 2020, 11(11):3274-3287

PubMed: 32231733 ( click the link to review the publication )

Neuroreport, 2020, 31(11):787-797

PubMed: 32568772 ( click the link to review the publication )

Cancers (Basel), 2020, 12(7):1824

PubMed: 32645997 ( click the link to review the publication )

Cell Res, 2019, 29(7):562-578

PubMed: 31201382 ( click the link to review the publication )

Mol Cell, 2019, 73(5):915-929

PubMed: 30849395 ( click the link to review the publication )

Nat Commun, 2019, 10(1):3779

PubMed: 31439829 ( click the link to review the publication )
Nat Commun, 2019, 10(1):1473

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Nat Commun, 2019, 10(1):993

PubMed: 30824690 ( click the link to review the publication )

Sci Adv, 2019, 5(8):eaav0318

PubMed: 31803841 ( click the link to review the publication )

Cell Syst, 2019, 8(2):163-167

PubMed: 30797774 ( click the link to review the publication )

Cell Syst, 2019, 9(1):74-92.e8

PubMed: 31302152 ( click the link to review the publication )

J Cell Biol, 2019, 218(4):1250-1264

PubMed: 30728176 ( click the link to review the publication )

EBioMedicine, 2019, 41:244-255

PubMed: 30876762 ( click the link to review the publication )

Cell Death Dis, 2019, 10(6):385

PubMed: 31097686 ( click the link to review the publication )

Ther Adv Med Oncol, 2019, 11:1758835919846375

PubMed: 31156720 ( click the link to review the publication )

J Mol Cell Biol, 2019, 10.1093/jmcb/mjz051

PubMed: 31174204 ( click the link to review the publication )

Curr Biol, 2019, 29(7):1232-1242.e5

PubMed: 30905608 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(9):1615-1627

PubMed: 31227645 ( click the link to review the publication )

FEBS J, 2019, 286(5):963-974

PubMed: 30600590 ( click the link to review the publication )

Mol Cancer Res, 2019, doi: 10

PubMed: 31604847 ( click the link to review the publication )

Mol Biol Cell, 2019, 30(13):1598-1609

PubMed: 31042116 ( click the link to review the publication )

Lab Invest, 2019, 99(9):1275-1286

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Sci Rep, 2019,

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Cell Div, 2019, 14:4

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J Biol Chem, 2019, 294(22):8760-8772

PubMed: 31010829 ( click the link to review the publication )

Front Genet, 2019, 10:411

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Open Biol, 2019, 9(8):190136

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Mol Reprod Dev, 2019, 86(8):972-983

PubMed: 31136049 ( click the link to review the publication )

Planta Med, 2019, 85(3):217-224

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Elife, 2019, 8e47097

PubMed: 31393265 ( click the link to review the publication )
Mol Cell, 2018, 71(1):117-128

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EMBO Mol Med, 2018, 10(9)

PubMed: 30108112 ( click the link to review the publication )

Theranostics, 2018, 8(10):2884-2895

PubMed: 29774081 ( click the link to review the publication )

Cancer Res, 2018, 78(2):572-583

PubMed: 29180474 ( click the link to review the publication )

Elife, 2018, 7:e36739

PubMed: 29897330 ( click the link to review the publication )

Sci Signal, 2018, 11(549)

PubMed: 30254057 ( click the link to review the publication )

Sci Signal, 2018, 11(530)

PubMed: 29764992 ( click the link to review the publication )

Pigment Cell Melanoma Res, 2018, 31(2):253-266

PubMed: 28972303 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2551-2563

PubMed: 30217967 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(7):1554-1565

PubMed: 29716963 ( click the link to review the publication )

Mol Cell Proteomics, 2018, 17(12):2434-2447

PubMed: 30217950 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(11):5300-5310

PubMed: 30133120 ( click the link to review the publication )

Hum Gene Ther, 2018, 29(8):886-901

PubMed: 29641320 ( click the link to review the publication )

Sci Rep, 2018, 8(1):3521

PubMed: 29476067 ( click the link to review the publication )

Cell Signal, 2018, 52:137-146

PubMed: 30223016 ( click the link to review the publication )

Cancer Med, 2018, 7(11):5589-5603

PubMed: 30221846 ( click the link to review the publication )

Transl Oncol, 2018, 11(4):852-863

PubMed: 29753186 ( click the link to review the publication )

PLoS One, 2018, 13(5):e0197165

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Onco Targets Ther, 2018, 11:5703-5713

PubMed: 30254463 ( click the link to review the publication )

J Oncol, 2018, 2018:3979527

PubMed: 30631355 ( click the link to review the publication )

Nucleic Acids Res, 2018, 46(20):10724-10739

PubMed: 30202980 ( click the link to review the publication )

Br J Cancer, 2018, 118(6):e13

PubMed: 29438360 ( click the link to review the publication )

Life Sci Alliance, 2018, 1(6):e201800223

PubMed: 30456393 ( click the link to review the publication )

Cell Res, 2017, 27(2):274-293

PubMed: 27958289 ( click the link to review the publication )
Mol Cell, 2017, 67(4):579-593

PubMed: 28781233 ( click the link to review the publication )

Mol Cell, 2017, 68(1):210-223e6

PubMed: 28985505 ( click the link to review the publication )

Nat Commun, 2017, 8(1):1506

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Nat Commun, 2017, 8:15289

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Dev Cell, 2017, 43(2):141-156.e7

PubMed: 29065306 ( click the link to review the publication )

Cancer Res, 2017, 77(5):1142-1154

PubMed: 27899378 ( click the link to review the publication )

Aging Cell, 2017, 16(3):575-584

PubMed: 28345297 ( click the link to review the publication )

Elife, 2017, 6e22513

PubMed: 28072388 ( click the link to review the publication )

Elife, 2017, 6

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Elife, 2017, 6e30523

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FASEB J, 2017, 32(2):625-638

PubMed: 28970258 ( click the link to review the publication )

Cell Chem Biol, 2017, 24(8):1017-1028

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Cell Physiol Biochem, 2017, 43(2):431-444

PubMed: 28922657 ( click the link to review the publication )

Curr Biol, 2017, 27(10):1477-1484

PubMed: 28479321 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(1):3-15

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FEBS J, 2017, 284(23):4035-4050

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J Cell Physiol, 2017, 232(10):2818-2828

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Sci Rep, 2017,

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Sci Rep, 2017, 7(1):8629

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J Biol Chem, 2017, 292(36):15028-15038

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Cell Signal, 2017, 39:74-83

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Am J Physiol Cell Physiol, 2017, 313(5):C501-C515

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Cell Biosci, 2017, 7:15

PubMed: 28344766 ( click the link to review the publication )

PLoS One, 2017, 12(1):e0170650

PubMed: 28125646 ( click the link to review the publication )
Biochem Biophys Res Commun, 2017, 484(4):864-870

PubMed: 28188792 ( click the link to review the publication )

Oncotarget, 2017, 9(13):10920-10933

PubMed: 29541386 ( click the link to review the publication )

Oncotarget, 2017, 8(23):37633-37645

PubMed: 28430578 ( click the link to review the publication )

Nat Chem Biol, 2016, 10.1038/nchembio.2017

PubMed: 26829474 ( click the link to review the publication )

Nat Commun, 2016, 7:11363

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Nat Commun, 2016, 7:10818

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Nat Chem Biol, 2016, 12(6):411-8

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Dev Cell, 2016, 37(2):174-189

PubMed: 27093086 ( click the link to review the publication )

J Cell Biol, 2016, 212(7):829-43

PubMed: 27002166 ( click the link to review the publication )

Cell Rep, 2016, 15(3):510-518

PubMed: 27068477 ( click the link to review the publication )

Elife, 2016, 5:e11402

PubMed: 26878753 ( click the link to review the publication )

PLoS Pathog, 2016, 12(8):e1005860

PubMed: 27579920 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(1):48-59

PubMed: 26586723 ( click the link to review the publication )

J Virol, 2016, 90(6):2794-805

PubMed: 26719254 ( click the link to review the publication )

Sci Rep, 2016, 6:19567

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J Biol Chem, 2016, 10.1074/jbc.M116.722751

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J Biol Chem, 2016, 10.1074/jbc.M115.712745

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J Biol Chem, 2016, 291(20):10904-15

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Cell Cycle, 2016, 15(15):2009-18

PubMed: 27249336 ( click the link to review the publication )

Cell Cycle, 2016, 15(16):2216-2225

PubMed: 27248858 ( click the link to review the publication )

Cell Cycle, 2016, 15(20):2753-65

PubMed: 27579997 ( click the link to review the publication )

PLoS One, 2016, 11(4):e0153818

PubMed: 27097159 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26580-92

PubMed: 27058891 ( click the link to review the publication )

Oncotarget, 2016, 7(12):15215-29

PubMed: 26934655 ( click the link to review the publication )
Head Neck, 2016, 10.1002/hed.24349

PubMed: 26713885 ( click the link to review the publication )

Oncotarget, 2016, 7(31):50215-50228

PubMed: 27384476 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(1):31-43

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Nat Cell Biol, 2015, 17(8):1024-35

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Nat Commun, 2015, 6:8388

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Nat Commun, 2015, 10.1038/ncomms8217

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Nat Commun, 2015, 6:6891

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Nat Commun, 2015, 6:8077

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Nat Commun, 2015, 6:6946

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Nat Commun, 2015, 6:10076

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Nat Commun, 2015, 6:10072

PubMed: 26656453 ( click the link to review the publication )

Genes Dev, 2015, 29(18):1969-79

PubMed: 26385965 ( click the link to review the publication )

Cancer Res, 2015, 75(2):405-14

PubMed: 25480943 ( click the link to review the publication )

J Cell Biol, 2015, 210(1):45-62

PubMed: 26124292 ( click the link to review the publication )

J Control Release, 2015, 204:20-9

PubMed: 25681050 ( click the link to review the publication )

J Control Release, 2015, 204:20-29

PubMed: ( click the link to review the publication )

Cancer Lett, 2015, 357(2):591-601

PubMed: 25524551 ( click the link to review the publication )

Mol Oncol, 2015, 9(2):527-43

PubMed: 25454348 ( click the link to review the publication )

Mol Cell Proteomics, 2015, 14(4):946-60

PubMed: 25659891 ( click the link to review the publication )

J Neurochem, 2015, 10.1111/jnc.13085

PubMed: 25727910 ( click the link to review the publication )

Mol Biol Cell, 2015, 26(3):440-52

PubMed: 25501367 ( click the link to review the publication )

J Biol Chem, 2015, 290(5):3033-44

PubMed: 25505268 ( click the link to review the publication )
J Biol Chem, 2015, 290(49):29617-28

PubMed: 26468278 ( click the link to review the publication )

Mol Biol Cell, 2015, 26(3):440-52

PubMed: ( click the link to review the publication )

Cell Cycle, 2015, 14(2):219-31

PubMed: 25607646 ( click the link to review the publication )

Cell Cycle, 2015, 14(7):1070-81

PubMed: 25602147 ( click the link to review the publication )

Oncotarget, 2015, 6(4):2315-30

PubMed: 25537513 ( click the link to review the publication )

Oncotarget, 2015, 6(7):5275-91

PubMed: 25779659 ( click the link to review the publication )

Oncotarget, 2015, 6(11):9327-40

PubMed: 25871386 ( click the link to review the publication )

Oncotarget, 2015, 6(33):34475-93

PubMed: 26439686 ( click the link to review the publication )

Oncotarget, 2015, 6(4):2315-30

PubMed: 25537513 ( click the link to review the publication )

Nat Cell Biol, 2014, 16(6):538-49

PubMed: 24776885 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(12):3211-21

PubMed: 24771642 ( click the link to review the publication )

Cancer Res, 2014, 74(20):5878-90

PubMed: 25125659 ( click the link to review the publication )

ACS Chem Biol, 2014, 9(5):1160-71

PubMed: 24568369 ( click the link to review the publication )

Antimicrob Agents Chemother, 2014, 13(5):1054-66

PubMed: 24748653 ( click the link to review the publication )

J Biol Chem, 2014, 289(38):26344-56

PubMed: 25100726 ( click the link to review the publication )

J Biol Chem, 2014, 289(18):12313-29

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J Biol Chem, 2014, 289,14066-14074

PubMed: ( click the link to review the publication )

J Biol Chem, 2014, 289(20):14066-74

PubMed: 24706748 ( click the link to review the publication )

Cell Cycle, 2014, 13(23):3685-97

PubMed: 25483079 ( click the link to review the publication )

Cell Cycle, 2014, 13(2):303-14

PubMed: 24247149 ( click the link to review the publication )

Cell Cycle, 2014, 13(24):3867-77

PubMed: 25558830 ( click the link to review the publication )

Cell Cycle, 2014, 13(14):2248-61

PubMed: 24875404 ( click the link to review the publication )

Biosci Rep, 2014, 34(3)

PubMed: 24844881 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )
PLoS One, 2014, 9(12):e115228

PubMed: 25542032 ( click the link to review the publication )

PLoS One, 2014, 8(10):e77053

PubMed: 24204733 ( click the link to review the publication )

Oncotarget, 2014, 5(12):4370-83

PubMed: 24970797 ( click the link to review the publication )

Oncotarget, 2014, 5(3):667-78

PubMed: 24525428 ( click the link to review the publication )

Oncotarget, 2014, 5(18):8379-92

PubMed: 25268741 ( click the link to review the publication )

The University of Queensland, 2014, Fawzi Faisal A. Bokhari

PubMed: ( click the link to review the publication )

Assay Drug Dev Technol, 2014, 12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Dev Cell, 2013, 25(6):555-71

PubMed: 23769972 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2013, 110(32):13026-31

PubMed: 23878225 ( click the link to review the publication )

Genes Dev, 2013, 27(20):2259-73

PubMed: 24142876 ( click the link to review the publication )

Cancer Res, 2013, 73(22):6722-33

PubMed: 24101154 ( click the link to review the publication )

Cancer Res, 2013, 73(2):813-23

PubMed: 23144294 ( click the link to review the publication )

Cancer Res, 2013, 73(20):6310-22

PubMed: 24067506 ( click the link to review the publication )

Cell Rep, 2013, 4(4):803-16

PubMed: 23972993 ( click the link to review the publication )

Oncogene, 2013, 10.1038/onc.2013.518

PubMed: 24317508 ( click the link to review the publication )

Br J Cancer, 2013, 110(2):510-9

PubMed: 24327015 ( click the link to review the publication )

Gynecol Oncol, 2013, 128(3):461-9

PubMed: 23146687 ( click the link to review the publication )

J Cell Sci, 2013, 126(Pt 16):3627-37

PubMed: 23750008 ( click the link to review the publication )

Mol Biol Cell, 2013, 24(24):3819-31

PubMed: 24152729 ( click the link to review the publication )

J Biol Chem, 2013, 288(33):23765-75

PubMed: 23814058 ( click the link to review the publication )

J Biol Chem, 2013, 288(20):14158-69

PubMed: 23504319 ( click the link to review the publication )

Invest Ophthalmol Vis Sci, 2013, 54(13):8353-63

PubMed: 24366665 ( click the link to review the publication )

Cancer Biol Ther, 2013, 14(5):436-49

PubMed: 23377828 ( click the link to review the publication )

Cell Cycle, 2013, 12(14):2255-65

PubMed: 24067368 ( click the link to review the publication )
PLoS One, 2013, 8(10):e77390

PubMed: 24155950 ( click the link to review the publication )

J Biomol Screen, 2013, 18(1):54-66

PubMed: 22923784 ( click the link to review the publication )

Biol Open, 2013, 2(5):479-86

PubMed: 23789096 ( click the link to review the publication )

Biol Open, 2013, 2(10):1022-31

PubMed: 24167712 ( click the link to review the publication )

Cancer Res, 2013, 73(22):6667-78

PubMed: 23983103 ( click the link to review the publication )

Cell Cycle, 2013, 12(9):1340-51

PubMed: 23574746 ( click the link to review the publication )

J Biol Chem, 2012, 287(6):4376-85

PubMed: 22184120 ( click the link to review the publication )

J Biol Chem, 2012, 287(21):17088-99

PubMed: 22467873 ( click the link to review the publication )

Cell Cycle, 2012, 11(3):543-53

PubMed: 22262171 ( click the link to review the publication )

PLoS One, 2012, 7(10):e46546

PubMed: 23056340 ( click the link to review the publication )

PLoS One, 2012, 7(6):e38838

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Biotechniques, 2012, 10.2144/000113866

PubMed: ( click the link to review the publication )

Biotechniques, 2012, 53(1)

PubMed: 26307252 ( click the link to review the publication )

Nat Cell Biol, 2011, 13(10):1265-71

PubMed: 21874008 ( click the link to review the publication )

Cancer Res, 2011, 71(4):1385-95

PubMed: 21303981 ( click the link to review the publication )

Cancer Res, 2011, 71(17):5659-69

PubMed: 21693658 ( click the link to review the publication )

J Cell Biol, 2011, 193(6):1083-99

PubMed: 21646404 ( click the link to review the publication )

Oncogene, 2011, 30(46):4666-77

PubMed: 21602893 ( click the link to review the publication )

J Invest Dermatol, 2011, 131(9):1886-95

PubMed: 21654832 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description

Features

The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

Targets

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. ^[1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{noWWlEPTB;MD6wNFc4PiEQvF2=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ACN	M1TpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFvPfpRKSzVyPUCuNFA5PDNizszN	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-8	NFzTUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTBwMEC5OFEh\|ryP	NWiz[W1KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LC-2-ad	NFG1RWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF\sXVZKSzVyPUCuNFExQTNizszN	Mnn6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ALL-PO	M4\Oc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWCxUYl7UUN3ME2wMlAyOyEQvF2=	NWO2PHBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-16	M3u1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{ftTWlEPTB;MD6wNVM{PiEQvF2=	NV\ifVRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KM12	M1\vXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1zycGlEPTB;MD6wNVM1QCEQvF2=	NIi2WFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GI-1	M1jtOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{TXSmlEPTB;MD6wNVM5OyEQvF2=	NG\mN449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-411N	NF3TRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGLKXmVKSzVyPUCuNFE1ODdizszN	NIPrcm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES8	Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXS5UmM6UUN3ME2wMlAyPDl2IN88US=>	NFjaRpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C2B	NH\HVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEO1UXpKSzVyPUCuNFE2OjZizszN	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CESS	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEXs[FZKSzVyPUCuNFE3ODJizszN	MkXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
697	NFjoc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFvtW2pKSzVyPUCuNFE3PjhizszN	NUjtemUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1963	NHjS[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHnPPGtKSzVyPUCuNFE3PzNizszN	NVy4PVN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
IA-LM	Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX3Jc2JuUUN3ME2wMlAyPjh6IN88US=>	NVTZWIZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SW954	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWnJR\|UxRTBwMEG3NFUh\|ryP	NF3iNmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RL95-2	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTBwMEG3N\|gh\|ryP	NIPvfFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LXF-289	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGjwXI9KSzVyPUCuNFE4PyEQvF2=	M{D2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OCUB-M	MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zUUGlEPTB;MD6wNVgzPiEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RKO	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIOwbpZKSzVyPUCuNFE6QDdizszN	Mn;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LOUCY	M4DPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXvqc4s5UUN3ME2wMlAzODVizszN	NWDn[3pPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NOS-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYXF[JFLUUN3ME2wMlAzODl\|IN88US=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A4-Fuk	NWX1bHdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFXNUWhKSzVyPUCuNFIzOThizszN	NHvvTpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
A388	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4P5fmlEPTB;MD6wNlIzPyEQvF2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-9	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFzkWGVKSzVyPUCuNFIzPjFizszN	M3[2elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KURAMOCHI	NGO0SWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{HUbGlEPTB;MD6wNlI5PSEQvF2=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KALS-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHHnNHhKSzVyPUCuNFI{OzhizszN	Mo\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HOP-62	NULsR2ZET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHjt[YZKSzVyPUCuNFI1OiEQvF2=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RPMI-8402	NVjTS\|RwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUPT[nY5UUN3ME2wMlAzPTB6IN88US=>	M1:0T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmPZTWM2OD1yLkCyOVEzKM7:TR?=	NHzNRZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CCRF-CEM	MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF7XXXhKSzVyPUCuNFI2PDNizszN	M4DBdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HUTU-80	M2rMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH7oVYxKSzVyPUCuNFI3OjRizszN	NWnQOnh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1648	Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYPlWoxCUUN3ME2wMlAzPjR5IN88US=>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HCE-4	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4DBTmlEPTB;MD6wNlY5OiEQvF2=	NEjMepY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ETK-1	Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4jiVGlEPTB;MD6wNlc{PiEQvF2=	NWPibXhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-15	M3\o[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2DrR2lEPTB;MD6wNlc{QCEQvF2=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BE-13	M1LUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGOz[4ZKSzVyPUCuNFI4PCEQvF2=	NUXYU\|VLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KE-37	Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHnPdXBKSzVyPUCuNFI4PDFizszN	NUH1ZXgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1355	NFrtVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlvaTWM2OD1yLkCyO\|g{KM7:TR?=	NXrrfpFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-11	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2DDd2lEPTB;MD6wNlgxQSEQvF2=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BL-70	M4fT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYe5d4djUUN3ME2wMlAzQDV5IN88US=>	M1LNZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ES6	NUX0SlRXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mm\PTWM2OD1yLkCyPFgyKM7:TR?=	NEfkUZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GT3TKB	MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH[xZZFKSzVyPUCuNFI6PTNizszN	NYHwWYtGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB647-SCLC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPsOGVKSzVyPUCuNFMyQTVizszN	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB13	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoDDTWM2OD1yLkCzN\|E3KM7:TR?=	NVz1fZduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ST486	M1PzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWXucZJyUUN3ME2wMlA{OzN5IN88US=>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H82	Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3;wZmlEPTB;MD6wN\|M1OyEQvF2=	NXzpUXhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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Calu-6	NEDkTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml:5TWM2OD1yLkC5OVk5KM7:TR?=	NIfGcFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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BB65-RCC	M2nUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;kTWM2OD1yLkGwNlk1KM7:TR?=	NF7CXlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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MDA-MB-134-VI	NFnMWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkftTWM2OD1yLkWwPVIyKM7:TR?=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SCC-3	MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlzkTWM2OD1yLkWxPFc{KM7:TR?=	M4C5R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KLE	NHLNfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTBwNUKxO\|Eh\|ryP	M2HobVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LB2241-RCC	MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFuyPXFKSzVyPUCuOVI2OjVizszN	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1417	NGHBO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGr0VoNKSzVyPUCuOVM1OzVizszN	NUHpRWxMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H2081	NGLwc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVyzZpp6UUN3ME2wMlU5PjFzIN88US=>	MnjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1522	NYrCfYhLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUPvSFNlUUN3ME2wMlU6Ozh\|IN88US=>	MnHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H889	M{\zbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVriTpBtUUN3ME2wMlU6QDR2IN88US=>	NEL5TZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CGTH-W-1	MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLVSpA3UUN3ME2wMlYxPzV3IN88US=>	NInpWZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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MHH-NB-11	NIjQVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX;DdHNTUUN3ME2wMlY{QDBzIN88US=>	NIGzeVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NCI-H69	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF3hb4pKSzVyPUCuOlQ5PzlizszN	NEHSTo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SCH	Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkPPTWM2OD1yLk[2NFI{KM7:TR?=	M4fCUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LS-513	MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlfLTWM2OD1yLk[3NlU6KM7:TR?=	M37zWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CP67-MEL	MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3\tU2lEPTB;MD62O\|U6PiEQvF2=	NWHteGtKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
GCIY	NX:0RWdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnXLTWM2OD1yLkewN\|Y{KM7:TR?=	NHO5[Gw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SHP-77	NHrYcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoXjTWM2OD1yLkewO\|M1KM7:TR?=	M2Czd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EHEB	NEjnTYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{TtOWlEPTB;MD63NVg2PCEQvF2=	MmWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
D-247MG	M3vzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnjwTWM2OD1yLkezNlMzKM7:TR?=	NVfZVZlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
Raji	MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1;GTWlEPTB;MD63OFk5QSEQvF2=	M3TTeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MPP-89	M17PNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGDSPHhKSzVyPUCuO\|U6PzhizszN	M{jPc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EKVX	MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoqxTWM2OD1yLke5NFc{KM7:TR?=	Mn;vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HCC2218	M4\FS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2jybGlEPTB;MD63PVE{OSEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KNS-81-FD	NGTTTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlvBTWM2OD1yLkixNFEyKM7:TR?=	NGX6RlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HCC2157	NIf5XHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M16wR2lEPTB;MD64OFk2OSEQvF2=	MlPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
BT-474	MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1XCeWlEPTB;MD64PFg2PCEQvF2=	NVfDPGZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H748	NFLvXpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWnmU5RIUUN3ME2wMlkyOiEQvF2=	NFrKWpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NCI-H2196	M2nUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{HEPWlEPTB;MD65O\|c4PyEQvF2=	NFvXR\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HAL-01	NELBcIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFLabHpKSzVyPUCuPVk5PzJizszN	NUSwNoRKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H2107	NXfyfGh5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1X0Z2lEPTB;MT6wNVg2PCEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB996-RCC	Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXm4PFhiUUN3ME2xMlA5ODVzIN88US=>	MoryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1395	NGj0RXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFP0U25KSzVyPUGuNVA3PyEQvF2=	NXHtVnNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CHP-126	M4qwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2fafGlEPTB;MT6xOlE6QSEQvF2=	NFvNbXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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CAS-1	M4GzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUfJR\|UxRTFwM{SyN\|Eh\|ryP	M{Huc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
JVM-3	Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3UdGpKSzVyPUGuOFc5PTVizszN	NYfWWoxHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
DMS-153	M2O3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rxV2lEPTB;MT61O\|Y4PCEQvF2=	NIS1OoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SK-MEL-2	MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkjrTWM2OD1zLkexO\|g6KM7:TR?=	NFXOZVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NCI-H1092	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWLsc5VyUUN3ME2xMlc3OTh{IN88US=>	MnqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LU-165	NXT3RYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1eyZ2lEPTB;MT64OlQ4PiEQvF2=	MkLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HL-60	NV3ldo9mT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2XadmlEPTB;MT65PVkxQCEQvF2=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
REH	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;PS2VQUUN3ME2yMlAxPTh{IN88US=>	NHHLboo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
JVM-2	MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYPaXFdpUUN3ME2yMlA3OTN3IN88US=>	NWq0RZFIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MN-60	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWrJR\|UxRTJwMUezNFgh\|ryP	Ml3EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SCC-15	M1eye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2S0c2lEPTB;Mj6yNFI4KM7:TR?=	NFrnUIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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TGW	NFfYTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVL6O2ZZUUN3ME2yMlM2ODJ5IN88US=>	NFXlUJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NCI-H23	NFK5O\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{DBUWlEPTB;Mj64NFc6OSEQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MMAC-SF	NVnGV3BPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{LEPGlEPTB;Mj64OlYzQCEQvF2=	NFXpWIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2171	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2Xzd2lEPTB;Mz6wN\|Q1QCEQvF2=	NFHCZYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
A704	NHnN[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEnkXJlKSzVyPUOuNVQyQTRizszN	MkDjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
DB	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEPtSGhKSzVyPUOuNlU2PzZizszN	M1rmdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H719	MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\oW2lEPTB;Mz6zNFM5PCEQvF2=	M1fOelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MC-CAR	M3\ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXHJR\|UxRTNwNUS4NVch\|ryP	NE\KNXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SIMA	NYn3V3dqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1rw[GlEPTB;Mz61PFQyPiEQvF2=	NHrWOm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SW872	MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWPJR\|UxRTNwN{ixNFEh\|ryP	M3:wOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC1187	M2nXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1izT2lEPTB;Mz63PFMyPSEQvF2=	NUDLTlE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-13	Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M37MXmlEPTB;Mz64N\|QyPyEQvF2=	NFnkPFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-SNU-1	MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXnoWWhCUUN3ME20MlIyQTl7IN88US=>	NV3tcHdVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H226	M3voeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXfNeYM3UUN3ME20MlM{PjB4IN88US=>	NH;SS2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RPMI-8866	MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml3HTWM2OD12LkO2NFI6KM7:TR?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
OCI-AML2	NWPp[YpsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWHJR\|UxRTRwNUWyN{DPxE1?	Mne2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LU-65	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVnxVVNCUUN3ME20Mlk{ODN\|IN88US=>	M2ToNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SK-N-DZ	NHf1NXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX7JR\|UxRTVwNkO0OlUh\|ryP	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB14	M{TLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmPnTWM2OD13Lkm3NVM2KM7:TR?=	Ml;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
COLO-829	NXm2UFlpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoS3TWM2OD14LkOzN\|U6KM7:TR?=	NGnpWXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MHH-CALL-2	NEnmfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NETBRWVKSzVyPU[uOVE2ODhizszN	NFHUN4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1770	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mlf4TWM2OD14Lk[2PVA1KM7:TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ECC4	M4jtb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml7HTWM2OD14LkiyNVc6KM7:TR?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A498	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWTmb3JlUUN3ME22Mlg4OTl{IN88US=>	NXLjepg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
DMS-79	M{\HZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXm3e2pnUUN3ME23MlA1PTF{IN88US=>	NEnEVGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
P30-OHK	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVjJR\|UxRTdwMkG5NFYh\|ryP	MmTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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RCC10RGB	NGS0ZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGq0VnFKSzVyPUiuNFYzQCEQvF2=	M4D0dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
U-698-M	Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{LlO2lEPTB;OD6yPVIzPiEQvF2=	M2e2[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BB49-HNC	M1vMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTlwNEKyOlUh\|ryP	MkG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES1	M3vjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXjJR\|UxRTlwNki5OVYh\|ryP	NUeyfHN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MFM-223	Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIn4OpJKSzVyPUGwMlk6OjdizszN	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
C2BBe1	NFe0WXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlHvTWM2OD1zMT6zOVI{KM7:TR?=	NF\n[4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EB2	Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3[5NGlEPTB;MUKuOlg5OSEQvF2=	M{DWVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
C8166	NELMcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTF\|LkizNFMh\|ryP	NV7hV4ViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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NCI-H1650	NFPE[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3rYWmlEPTB;MU[uN\|c3PSEQvF2=	MkPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
Mo-T	NVTjeo5TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWHBNHd6UUN3ME2xO{41ODJ7IN88US=>	M1vsUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NB7	MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mk\TTWM2OD1zNz63OFY4KM7:TR?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES7	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWLSWlRzUUN3ME2xPU42PTB5IN88US=>	NIDHOmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES5	NXLuRXBKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjZT2tKSzVyPUKxMlc3PzFizszN	Mn\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MSTO-211H	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV\Z[ZNEUUN3ME2yNU45QDV6IN88US=>	NWj6XIZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
U-87-MG	NVy2WGppT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mmi4TWM2OD1{NT6xPVY3KM7:TR?=	Mn;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
THP-1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn;jTWM2OD1{OT63NlAyKM7:TR?=	MlLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB10	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlLXTWM2OD1\|MD6yOlk1KM7:TR?=	NEj4NJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NH-12	NWThVYw2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUC5OJB3UUN3ME2zN{4zODF5IN88US=>	MoHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
COLO-824	NXfIPI9FT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4nZfWlEPTB;M{SuNVAxPiEQvF2=	M1LPOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SKM-1	NViw[Gd5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXHWSYgzUUN3ME2zO{45PDJ{IN88US=>	NWXWOllzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1838	NWLKdHBsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NInORYZKSzVyPUO4MlM4QTdizszN	MonCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RL	NIrtZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXrlZ2NMUUN3ME2zPU4zPDd5IN88US=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-800	M{XZRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkG4TWM2OD12MD6wO\|c{KM7:TR?=	M{LkZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KG-1	NGr5PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIK2THBKSzVyPUSwMlg6PTVizszN	M1rkWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TUR	MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1GzTmlEPTB;NEGuOlM6QSEQvF2=	M2TpTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LNCaP-Clone-FGC	M1fjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jHW2lEPTB;NEGuPVAyPyEQvF2=	M{LxU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H322M	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXvOdVNIUUN3ME20Nk42QTh2IN88US=>	NIDSNpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LNCaP	NGrDPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnqwTWM2OD17MT6zJI5O	MljKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MEWxO\|QoRjJ3NUC1NVc1RC:jPh?=
C4-2	M2rpRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkDUTWM2OD16IH7N	NVzlZolxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NFUyPzRpPkK1OVA2OTd2PD;hQi=>
JURKAT	MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NG\QeJgzPCCq		NHXIOJNKSzVyPUSxOk43PiCwTR?=	Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NETVcm8zPCCq		NXrkeXA{UUN3ME2yPFU{NjVibl2=	MmnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
REH	Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4nPe\|I1KGh?		M4HsRmlEPTB;Mki3MlY5KG6P	NVT3NHp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-6	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVuyOEBp		MoTMTWM2OD1\|NEOzNEBvVQ>?	M4LvUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	M4PGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1myRlI1KGh?		NWXyXIgyUUN3ME21NVkvODVibl2=	M{TLZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	NYHRSJY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NV\zRldZOjRiaB?=		NXPJOpZTUUN3ME2yNVA4NjFibl2=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	NYjVfY1xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M{ixSlI1KGh?		MXTJR\|UxRTF7OT63O{BvVQ>?	NHTxZWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
CEM	NVvFfVZFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmGyNlQhcA>?		MWjJR\|UxRTV{LkG4JI5O	NX\SXGIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
P12	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M4LtT\|I1KGh?		NGTHfWdKSzVyPUO5MlI4KG6P	NW\zOXVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-16	Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MoHCNlQhcA>?		MnLXTWM2OD17Nj6yPEBvVQ>?	NWe3TpBkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
JURKAT	M1S4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NW\hR3BDPDhiaB?=		M4P6OGlEPTB;MUSuPFQhdk1?	NV:5fnNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
MOLT-4	NWruT\|ZST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYXpZpRRPDhiaB?=		MUTJR\|UxRTJ4Lk[gcm0>	NXTISWl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
REH	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NV;scZluPDhiaB?=		NXu2NYJDUUN3ME20OE44OSCwTR?=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-6	NEnQTWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MUm0PEBp		M2DJW2lEPTB;MkOuNlYhdk1?	NVizelhFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
RS 4;11	NFPvXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NH3tTok1QCCq		MWTJR\|UxRTF4ND6yPEBvVQ>?	M335eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MWK0PEBp		M1LIbGlEPTB;M{C1MlMhdk1?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	NGfRVYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnnCOFghcA>?		MmqyTWM2OD15ND62NkBvVQ>?	MorQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
CEM	NVXveIx4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnW4OFghcA>?		NYLDUG9SUUN3ME2yOE42PSCwTR?=	M{TDWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	M2\jRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{LGdVQ5KGh?		MWXJR\|UxRTF6LkS2JI5O	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NFTrR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXzYZpZkPDhiaB?=		M1rPbWlEPTB;NkOuNlQhdk1?	NXvYfpR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
JURKAT	MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M{DkTVczKGh?		M1LmS2lEPTB;Mz62OUBvVQ>?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
MOLT-4	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkXKO\|IhcA>?		MnfLTWM2OD15LkO5JI5O	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
REH	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHjiOXo4OiCq		NUPHb2NpUUN3ME2xOk4xOSCwTR?=	NIDvdYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-6	NUL4[ZFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M{PqdVczKGh?		M1;CZmlEPTB;MT63PEBvVQ>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
RS 4;11	M3fPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVLzXlZ4PzJiaB?=		MlvMTWM2OD12LkO4JI5O	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
697	NXztPFB1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NI\Lb2g4OiCq		MVnJR\|UxRTd2LkK4JI5O	NECwO4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
SIL-ALL	NFTN[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1faOlczKGh?		M{TRdWlEPTB;Nz6yJI5O	NImxW289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
CEM	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MYS3NkBp		NXXHN5ZNUUN3ME21MlQzKG6P	NITzZ5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
P12	M{HScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NXzUV5B[PzJiaB?=		MYnJR\|UxRTZwM{egcm0>	NHzlTm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-16	MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3\ielczKGh?		MnfZTWM2OD15Nz63N{BvVQ>?	Mlz2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
Y79	M3[0VGFxd3C2b4Ppd{BCe3OjeR?=	NHjEcWsyNTVyIH7N	NYf6cYJlOTJxMkSgbC=>	M3HxRmROW09?	MmLObY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	NYLJdWE5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlY3PjVpPkK0N\|Y3PjZ3PD;hQi=>
WER-Rb-1	NF7Qb3lCeG:ydH;zbZMhSXO\|YYm=	NF3FSJEyNTVyIH7N	NYPrZ5RlOTJxMkSgbC=>	MofxSG1UVw>?	M1TGRYlv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=>	M2XiUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[2OlY2Lz5{NEO2OlY3PTxxYU6=
G7	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{no[WlEPTB;Mz6zJI5O	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEezN{c,OjR{MES3N\|M9N2F-
G166	MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEjxXWFKSzVyPUeuNEBvVQ>?	NEfhU2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB660	NH3O[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRTZwNDDuUS=>	NFTrd3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB1117	NWLWfWllT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHn1PI9KSzVyPUG1MlYhdk1?	MnPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
KB-3-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWflR3JZUUN3ME2xMlQ5KMLzIECuOVMhdk1?	M{HrTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
KB-8-5-11	Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlfnTWM2OD13LkCxJOKyKDJwMEGgcm0>	M2naOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
KB-C-1	NFq5c41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEH0XoZKSzVyPUG2Mlc3KMLzIESuOVEhdk1?	NVi2W3FGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
KB-V-1	NEDub2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVjJW5Y1UUN3ME2yPFEvOjRiwsGgN\|EvPTdibl2=	NIPyco09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
OVCAR-8	NV7IUJFqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{D2OmlEPTB;Nz6xPUDDuSB\|Lk[wJI5O	NH6zeXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
NCI-ADR-RES	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn76TWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?=	M1e2OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
MCF7	Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MormTWM2OD13LkGxJOKyKDFwNEegcm0>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MCF7-FLV1000	NY\xfYVVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1L6WGlEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P	MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
S1	MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTJ2LkOwJOKyKDRwN{Wgcm0>	M{DzNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
S1-M1-80	M3PT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnTUTWM2OD1{NkGuNFYhyrFiNEiuNlUhdk1?	NYT6RllrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
CORL-23/P	M{nNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTRwM{igxtEhOS5{NTDuUS=>	M164cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
CORL-23/R	NVTBZWlnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYnJR\|UxRTVwMU[gxtEhOS56MzDuUS=>	Ml7vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
NIH3T3	M3frc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlnETWM2OD12MD62NEDDuSB2Lkm3JI5O	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
NIH3T3-G185	NUDSbppsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmL1TWM2OD1{NEGzMlQxKMLzIESyN{43PiCwTR?=	NW[2e291RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
pcDNA-HEK293	NVXI[\|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH73bZdKSzVyPUKuO\|UhyrFiMD62O{BvVQ>?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MDR19-HEK293	M4PN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV\JR\|UxRTh3LkWwJOKyKDF\|Lk[3JI5O	NInoXVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
R482-HEK293	NGrzfYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2H4eWlEPTB;MkWuPVchyrFiND65OUBvVQ>?	MmrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MRP1-HEK293	Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXLJR\|UxRTJwOUmgxtEhOS52OTDuUS=>	MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
SF188	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn75NVAuOTByIH7N	Ml7JNlQuQTZiaB?=	MoX4SG1UVw>?	NUK5VXlZcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy	MmDkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OEe2OFUoRjJ\|OEi3OlQ2RC:jPh?=
T98G	NWDSdZozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlvyNVAuOTByIH7N	NHnie5EzPC17NjDo	NHT0ZlhFVVOR	NYnhSmNZcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZ49v[2WwdILheIlwdi1iZHXw[YRmdnRibXHucoVz	Ml7NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OEe2OFUoRjJ\|OEi3OlQ2RC:jPh?=
DU145	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXLEUXNQ	M{\HdWlEPTEkiMy2NEBvVQ>?	M4GzXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEi0OFI5Lz5{M{i4OFQzQDxxYU6=
LNCaP	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NGS4[JdFVVOR	MlfmTWM2OOLKvEe1JI5O	NYPlTIhpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFQ1OjhpPkKzPFg1PDJ6PD;hQi=>
PC3	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFKycGFFVVOR	MoDiTWM2OOLKvEG3OUBvVQ>?	NXLKeldPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFQ1OjhpPkKzPFg1PDJ6PD;hQi=>
RT4	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRTJ5LkKxJI5O	M3LxU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{myOlM6Lz5{M{e5NlY{QTxxYU6=
5637	M1\6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3[zWGlEPTB;NEWuOFchdk1?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
T24	NFXIUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXV[WlKSzVyPUe5MlEzKG6P	M4LjeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{myOlM6Lz5{M{e5NlY{QTxxYU6=
MCF7	NGfmbYFHfW6ldHnvckBCe3OjeR?=	NH7EOYUyODBibl2=	MmDCNUBp	MX\EUXNQ	NVHxWnBQemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT\|CpHNoczFuwrDQd\|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?=	M2T1XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{ewNlQ1Lz5{M{e3NFI1PDxxYU6=
KB-V1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MljDTWM2OD1\|LkmyJO69VQ>?	NV\3UXJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVMyQTZpPkKzOVk{OTl4PD;hQi=>
Hec50co	MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmPqTWM2OD13IH7N	M17wZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUS2Olg4Lz5{M{G0OlY5PzxxYU6=
MDA-MB-468	MVvBdI9xfG:\|aYOgRZN{[Xl?	Mo\MNU82NzFyIH7N	M1m1VVI1NzR6L{eyJIg>	MVXEUXNQ	MmrIbY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NGrHT\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0OFI6PCd-MkOxOFQzQTR:L3G+
MCF10A	M4XaRWFxd3C2b4Ppd{BCe3OjeR?=	MWmxM\|UwOTBibl2=	M3zF[FI1NzR6L{eyJIg>	MXfEUXNQ	MUPpcoR2[2W\|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	MnXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
Huh-7	NVn2N5h6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLQcINkOS9zMD:xNFAwOTByMDDuUS=>	M2P5TVQ5KGh?		MlTh[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5	NVi3fXNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFU2QDdpPkKyO\|Q2PTh5PD;hQi=>
Daoy	NET3ZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmX0NU45PzVvMkSwJI5O	NH3aV2s4OiCq	MU\EUXNQ	NXLuWYprUUN3ME21JI5O	NFmzUYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO5NFI4QSd-MkKzPVAzPzl:L3G+
ONS-76	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmnUNU45PzVvMkSwJI5O	MljJO\|IhcA>?	NHLpenRFVVOR	MkHjTWM2OD15LkWgcm0>	NVfvVlVvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzPVAzPzlpPkKyN\|kxOjd7PD;hQi=>
SUM 149	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHMUIsxNTFyMDDuUS=>	M{X3OFczKGh?		MWfpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	M{PPSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
MDA-MB-231	M2HUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1rxPFAuOTByIH7N	NH7OXWE4OiCq		MYjpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	M{PRR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
HR5	MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M17QXFAuOTByIH7N	M3PZeVczKGh?		NIe5U4xqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI>	NH;4c2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOwPVk{QSd-MkKzNFk6Ozl:L3G+
BT-474-M1	M1OzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fSU\|AuOTByIH7N	MVe3NkBp		MWfpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	M3m1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
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LAN-5	MojKdWhVWyCjc4PhfS=>				NX65S\|l2eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN?	MoTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Fibroblast cells	MnPtdWhVWyCjc4PhfS=>				NHfWVVRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiY3;ueJJwdCCKaDD3bYxlKHS7cHWg[oljem:kbHHzeEBk\Wyucx?=	NIT3S4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	MkXwdWhVWyCjc4PhfS=>				NGP6fIlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSi2HQnOxJINmdGy\|	MoDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	M1LVdZFJXFNiYYPzZZk>				MXvxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNVOKIHPlcIx{	MnzaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
A673	NEX6UIRyUFSVIHHzd4F6				MkDGdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRVY4OyClZXzsd{k>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-37	MWLxTHRUKGG\|c3H5				NEnsd\|VyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1\|NzDj[Yxtew>?	M{f3[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63(6-TG R)	MnHpdWhVWyCjc4PhfS=>				NVLkeW1reUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	NHTmSnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Fibroblast cells	NYrNW4ZSeUiWUzDhd5NigQ>?				M2fadZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJINwdnS{b3ygTIghf2muZDD0fZBmKG[rYoLvZoxie3RiY3XscJM>	NILHNI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
OHS-50	Ml;6dWhVWyCjc4PhfS=>				M3vGeZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>?	MonFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	NV\UOJh2eUiWUzDhd5NigQ>?				MkjmdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVmQh[2WubIO=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SJ-GBM2	NFm0dIxyUFSVIHHzd4F6				MkLKdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO=	MoXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC	NX64cJFTeUiWUzDhd5NigQ>?				MUjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB-EBc1	M1q0UJFJXFNiYYPzZZk>				NWrwR4lKeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CMWVD[zFiY3XscJM>	M33sdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5	NI\LNnNyUFSVIHHzd4F6				NX:ybVk3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz	NID0Sow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh18	MkmzdWhVWyCjc4PhfS=>				NVz5bVNpeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB1643	MmHtdWhVWyCjc4PhfS=>				MknNdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR\|IHPlcIx{	M1G1eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	MlTqdWhVWyCjc4PhfS=>				Mn3pdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2PQzDj[Yxtew>?	NVTOZoRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SJ-GBM2	NEnoSHVyUFSVIHHzd4F6				MVrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTTk1ISk1{IHPlcIx{	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
TC32	NXW4N48xeUiWUzDhd5NigQ>?				M3f3N5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHREOzJiY3XscJM>	M4XqeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	NV3xfplpeUiWUzDhd5NigQ>?				MlPBdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Saos-2	MVfxTHRUKGG\|c3H5				MXLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTZY9{NTJiY3XscJM>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
DU145	NGroRmNCeG:ydH;zbZMh[XO\|YYm=	MnPVNVAxKG6P	NUKwdYQxOjRiaILz		M{\vRmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iUFHSVEBkdGWjdnHn[UBifCBzMECgcm0h[W[2ZYKgNlQhcHK\|IHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	M1Lt[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
HeLa	MXrGeY5kfGmxbjDhd5NigQ>?	M33SdVExOCCwTR?=			MWfJcohq[mm2aX;uJI9nKFCOS{GgWIhzOjFyIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCKZVzhJINmdGy\|IHH0JFExOCCwTTDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	NInSdXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
DU145	NEm0XmJHfW6ldHnvckBie3OjeR?=	NVnCcJFlOTByIH7N			NH3qTIdKdmirYnn0bY9vKG:oIGDMT\|EheHKxdHXpckBi[2O3bYXsZZRqd25iaX6gbJVu[W5iRGWxOFUh[2WubIOgZZQhOTByIH7NJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	M{fRdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
HeLa	NYWzWnVsTnWwY4Tpc44h[XO\|YYm=	M4LJeVExOCCwTR?=			NVrYWVRpUW6qaXLpeIlwdiCxZjDQUGsyKHC{b4TlbY4h[WOldX31cIF1cW:wIHnuJIh2dWGwIFjlUIEh[2WubIOgZZQhOTByIH7NJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	NX7NfVlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	M172WWZ2dmO2aX;uJIF{e2G7	NX;jR2ZsOTByIH7N	NGrtVIUyQCCqcoO=		MXPJcoR2[3Srb36gc4YhdW:wb4DvcIFzKG2rdH;0bYMhe3CrbnTs[ZMhcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	NGfPRXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
HeLa	MoCzRZBweHSxc3nzJIF{e2G7	NYTISmp6OTByIH7N	NVzlRm5kOjRiaILz		NInYTJBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iUFHSVEBkdGWjdnHn[UBifCBzMECgcm0h[W[2ZYKgNlQhcHK\|IHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	M3TVUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
PC3	NHLYPG5HfW6ldHnvckBie3OjeR?=	MYexNFAhdk1?	NWPFcZV4OThiaILz		MYfJcoR2[3Srb36gc4YhdW:wb4DvcIFzKG2rdH;0bYMhe3CrbnTs[ZMhcW5iaIXtZY4hWEN\|IHPlcIx{KGG2IEGwNEBvVSCrbnP1ZoF1\WRiZn;yJFE5KGi{czDifUBqdmSrcnXjeEBqdW23bn;mcJVwemW\|Y3XuZ4UhdWmlcn;zZ49xgQ>?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
DU145	M1\VcGZ2dmO2aX;uJIF{e2G7	MnXrNVAxKG6P			Mn;hTY5pcWKrdHnvckBw\iCSTFuxJHRpejJzMDDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iRGWxOFUh[2WubIOgZZQhOTByIH7NJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-

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Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

In vivo

BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. ^[1]

Protocol

Kinase Assay: ^[1]	- Collapse Plk1 in vitro kinase assay: Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research: ^[1]	- Collapse Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc. Concentrations: Dissolved in DMSO, final concentrations ~1 μM Incubation Time: 24 and 72 hours Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: Female BomTac:NMRI-Foxn1^nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells Dosages: ~50 mg/kg Administration: Injection i.v. once or twice per week (Only for Reference)

References

Solubility (25°C)

In vitro	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	12.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI 2536 SDF

Molecular Weight	521.66
Formula	C₂₈H₃₉N₇O₃
CAS No.	755038-02-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
Answer:
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

Selective Plk Inhibitors

GSK461364 : Plk1-selective, K_i=2.2 nM.
Plk Inhibitor in Clinical Trial

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
Newest Plk Inhibitor

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
Calssic Plk Inhibitor

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

Related PLK Products

SBE 13 HCl ^New

SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.
Ro-3306 ^New

RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K_i of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.
CCG-1423 ^New

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.
HMN-214

HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
GSK461364

GSK461364 (GSK461364A) inhibits purified Plk1 with K_i of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3. Phase 1.

Features:Demonstrates >390-fold selectivity for Plk1 relative to Plk2 and Plk3.
Volasertib (BI 6727)

Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.

Features:A high volume of distribution, indicating good tissue penetration, and a long terminal half-life.
MLN0905

MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.
Ro3280

RO3280 (Ro5203280) is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Features:A selective PLK1 inhibitor. Demonstrates greater potency than BI2536. Potential use in nasopharyngeal carcinomas.
Onvansertib (NMS-P937)

Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.

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BI 2536