BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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Cited by 134 Publications

Purity & Quality Control

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Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NXXLSXhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEC3O|Yh|ryP MkS1V2FPT0WU
ACN M1;se2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTjVHdKSzVyPUCuNFA5PDNizszN Mn7TV2FPT0WU
TE-8 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i4[GlEPTB;MD6wNFk1OSEQvF2= MUXTRW5ITVJ?
LC-2-ad MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjITWM2OD1yLkCxNFk{KM7:TR?= Mo\0V2FPT0WU
ALL-PO M2HLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEGzJO69VQ>? NFjONItUSU6JRWK=
EW-16 NU\SSoZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fNTmlEPTB;MD6wNVM{PiEQvF2= NEP5[|dUSU6JRWK=
KM12 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\zSWlEPTB;MD6wNVM1QCEQvF2= NFrkTY1USU6JRWK=
GI-1 NYT5PGRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly3TWM2OD1yLkCxN|g{KM7:TR?= NEjLVG9USU6JRWK=
LS-411N M4HXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliwTWM2OD1yLkCxOFA4KM7:TR?= MWLTRW5ITVJ?
ES8 NGX2eJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DyfWlEPTB;MD6wNVQ6PCEQvF2= NIDKb5BUSU6JRWK=
SNU-C2B MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor6TWM2OD1yLkCxOVI3KM7:TR?= MlviV2FPT0WU
CESS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ZVmlEPTB;MD6wNVYxOiEQvF2= M4TiWnNCVkeHUh?=
697 M2HJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jFfWlEPTB;MD6wNVY3QCEQvF2= MofhV2FPT0WU
NCI-H1963 M2\pXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrBT4NKSzVyPUCuNFE3PzNizszN MmHVV2FPT0WU
IA-LM MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzEVVN[UUN3ME2wMlAyPjh6IN88US=> MkT0V2FPT0WU
SW954 M1K1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rUSmlEPTB;MD6wNVcxPSEQvF2= Ml;MV2FPT0WU
RL95-2 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHRO|FpUUN3ME2wMlAyPzN6IN88US=> NImwNWJUSU6JRWK=
LXF-289 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXlTWM2OD1yLkCxO|ch|ryP NUHvc2RRW0GQR1XS
OCUB-M MkL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq1TWM2OD1yLkCxPFI3KM7:TR?= NHHRUZlUSU6JRWK=
RKO M3LCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEG5PFch|ryP NVLnUlN4W0GQR1XS
LOUCY NVrFe5pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz2eY5lUUN3ME2wMlAzODVizszN M2X6fnNCVkeHUh?=
NOS-1 NXTVWFRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LYO2lEPTB;MD6wNlA6OyEQvF2= MXXTRW5ITVJ?
A4-Fuk M3ji[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEKyNVgh|ryP MoPmV2FPT0WU
A388 MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDPeZhKSzVyPUCuNFIzOjdizszN NEXMd3VUSU6JRWK=
TE-9 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLWTlJxUUN3ME2wMlAzOjZzIN88US=> NUHIRotHW0GQR1XS
KURAMOCHI NYOy[JNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W2b2lEPTB;MD6wNlI5PSEQvF2= NGTWZpZUSU6JRWK=
KALS-1 MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyzNoZmUUN3ME2wMlAzOzN6IN88US=> NUj0[lhjW0GQR1XS
HOP-62 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEK0NkDPxE1? M362OnNCVkeHUh?=
RPMI-8402 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEK1NFgh|ryP MV;TRW5ITVJ?
TE-1 NYHXfGdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrNenVKSzVyPUCuNFI2OTJizszN NXnNWZp5W0GQR1XS
CCRF-CEM NFOwRW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIixfFFKSzVyPUCuNFI2PDNizszN MXPTRW5ITVJ?
HUTU-80 M3[2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:xWHFKSzVyPUCuNFI3OjRizszN NIHxTGtUSU6JRWK=
NCI-H1648 NUHqWo1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfFepBKSzVyPUCuNFI3PDdizszN MVTTRW5ITVJ?
HCE-4 NEHmbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPINJZKSzVyPUCuNFI3QDJizszN MVfTRW5ITVJ?
ETK-1 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEK3N|Yh|ryP NF3xXHFUSU6JRWK=
TE-15 NYnLV4prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEK3N|gh|ryP MkHOV2FPT0WU
BE-13 NG[yN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLzNnpKSzVyPUCuNFI4PCEQvF2= Mk\KV2FPT0WU
KE-37 NV\HUWN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSwdJlKSzVyPUCuNFI4PDFizszN MVjTRW5ITVJ?
NCI-H1355 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TodGlEPTB;MD6wNlc5OyEQvF2= Mo\oV2FPT0WU
TE-11 M{PvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm5XHBKSzVyPUCuNFI5ODlizszN NV;MbFlHW0GQR1XS
BL-70 NVrCZW5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz3SXZKSzVyPUCuNFI5PTdizszN NXj6V|FyW0GQR1XS
ES6 NUCxXpZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjIS49KSzVyPUCuNFI5QDFizszN NILUUWFUSU6JRWK=
GT3TKB NF3Pbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvDTWM2OD1yLkCyPVU{KM7:TR?= MV7TRW5ITVJ?
LB647-SCLC M4THcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3LTWM2OD1yLkCzNVk2KM7:TR?= NVq2ZXpVW0GQR1XS
NB13 NFy4cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEOzNVYh|ryP NYPieo93W0GQR1XS
ST486 NYS5UYxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEOzN|ch|ryP NEnwZ5FUSU6JRWK=
NCI-H82 NUHte4M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq0RlZIUUN3ME2wMlA{OzR|IN88US=> Ml22V2FPT0WU
NTERA-S-cl-D1 NHzWS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjWOHp6UUN3ME2wMlA{Ozl7IN88US=> MmPRV2FPT0WU
ES4 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITifGdKSzVyPUCuNFM1PjNizszN NHS4c4xUSU6JRWK=
SK-NEP-1 NEfEb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\5eGlEPTB;MD6wN|Q6QSEQvF2= MVnTRW5ITVJ?
Becker NVG3b2lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fiVmlEPTB;MD6wN|U2PSEQvF2= NWDjd2lQW0GQR1XS
A101D NXTjOnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEO3OFgh|ryP M{jIVXNCVkeHUh?=
SK-UT-1 NXrxbFhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\oTWM2OD1yLkCzO|c1KM7:TR?= Mn;OV2FPT0WU
SW982 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fNfWlEPTB;MD6wN|c6KM7:TR?= Ml7PV2FPT0WU
TE-10 NGHOSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2iyR2lEPTB;MD6wOFA1PiEQvF2= M1PSOXNCVkeHUh?=
OVCAR-4 NXzvNlgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LzTmlEPTB;MD6wOFA2QSEQvF2= NWTiTWprW0GQR1XS
KP-N-YS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMESwPFUh|ryP M3\mcnNCVkeHUh?=
BL-41 NY\YZmk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TGUGlEPTB;MD6wOFEzPSEQvF2= M3nxNXNCVkeHUh?=
MZ1-PC M{\4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOyTWM2OD1yLkC0NVI4KM7:TR?= MVfTRW5ITVJ?
PF-382 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV21[|RTUUN3ME2wMlA1OTl6IN88US=> NHvLcGFUSU6JRWK=
MOLT-13 MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1O2lEPTB;MD6wOFI{QCEQvF2= NY\yWldXW0GQR1XS
HCC1599 M{P1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DET2lEPTB;MD6wOFI2QCEQvF2= NVLrV2dSW0GQR1XS
IST-MEL1 NXHqOmxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMES0OFIh|ryP Mm\qV2FPT0WU
LU-139 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMES0OFIh|ryP MXfTRW5ITVJ?
MS-1 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoflTWM2OD1yLkC0O|AyKM7:TR?= NVT1UG5vW0GQR1XS
MFH-ino NX3KO|Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DsTWlEPTB;MD6wOVAxOyEQvF2= MmPyV2FPT0WU
IMR-5 NIjkTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEWwNlEh|ryP NFrYXWZUSU6JRWK=
TE-5 NEH6Z|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrPTWM2OD1yLkC1NFY{KM7:TR?= NVLQSmlFW0GQR1XS
DJM-1 NIfBbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L0W2lEPTB;MD6wOVE1OiEQvF2= NIHpTldUSU6JRWK=
NB17 NWfXcYtbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPDUnBKSzVyPUCuNFUzODdizszN MXzTRW5ITVJ?
KARPAS-45 M2H0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDVNm9KSzVyPUCuNFU{PThizszN NELweXVUSU6JRWK=
TGBC1TKB M3XoSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jye2lEPTB;MD6wOVQxPSEQvF2= Mkn0V2FPT0WU
ML-2 M4\zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KwR2lEPTB;MD6wOVQyPCEQvF2= NX3vV3VYW0GQR1XS
no-10 NXn0Vm1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\mVGlEPTB;MD6wOVQ4PCEQvF2= M2ntWHNCVkeHUh?=
CTV-1 M4\sO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\1TWM2OD1yLkC1OVAzKM7:TR?= NYewV5FqW0GQR1XS
SJSA-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPUbodKSzVyPUCuNFU2OiEQvF2= NVKzXFBTW0GQR1XS
HC-1 NYLNcZgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjudWRGUUN3ME2wMlA2PTl5IN88US=> NV7hNmd1W0GQR1XS
TE-12 M4TTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEW2NVMh|ryP MY\TRW5ITVJ?
KY821 M13Gd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITvWXZKSzVyPUCuNFU3OzJizszN NUPBZ|VzW0GQR1XS
TALL-1 NUnO[mRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXPZWNQUUN3ME2wMlA2PzB6IN88US=> M3m5bHNCVkeHUh?=
DEL NFnxfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT2U5dSUUN3ME2wMlA2PzB7IN88US=> M3Sw[3NCVkeHUh?=
TE-6 NWHDVlJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D4[2lEPTB;MD6wOVczOiEQvF2= MVHTRW5ITVJ?
SK-LMS-1 NWmyWIExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu1WI04UUN3ME2wMlA2QDB3IN88US=> NHjWSnJUSU6JRWK=
EW-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP2S|hKSzVyPUCuNFU5OzdizszN NVXBVYJDW0GQR1XS
8-MG-BA MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEW4OVEh|ryP M2fFd3NCVkeHUh?=
NALM-6 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TmNWlEPTB;MD6wOVk4OyEQvF2= NHO0RWdUSU6JRWK=
LB771-HNC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrGTWM2OD1yLkC1PVc6KM7:TR?= M{P0SXNCVkeHUh?=
HT-144 NH7DWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwME[xN{DPxE1? MXrTRW5ITVJ?
KM-H2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon4TWM2OD1yLkC2NlIyKM7:TR?= Moq0V2FPT0WU
SF268 M{L3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Ph[2lEPTB;MD6wOlI5PiEQvF2= M1;Re3NCVkeHUh?=
RS4-11 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGixRpFKSzVyPUCuNFY{ODRizszN M2i1enNCVkeHUh?=
MHH-PREB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS5d|YyUUN3ME2wMlA3OzF7IN88US=> M2PmTHNCVkeHUh?=
ATN-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLWTWM2OD1yLkC2N|Q2KM7:TR?= NHr0O2NUSU6JRWK=
BB30-HNC NUTzTVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TQO2lEPTB;MD6wOlQ{PiEQvF2= NGnaPItUSU6JRWK=
CPC-N M{TEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHYSIxKSzVyPUCuNFY2OjRizszN MYfTRW5ITVJ?
NB1 M{W5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3WwV2lEPTB;MD6wOlYyOyEQvF2= NYS1b5FuW0GQR1XS
KS-1 MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXTTWM2OD1yLkC2O|Q5KM7:TR?= NVLP[Zl7W0GQR1XS
RXF393 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3kcIVKSzVyPUCuNFY4PjRizszN MlH1V2FPT0WU
IST-SL2 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSxb|dtUUN3ME2wMlA4ODB2IN88US=> Mnr4V2FPT0WU
GI-ME-N MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DMRmlEPTB;MD6wO|I5PiEQvF2= M3ThNnNCVkeHUh?=
VA-ES-BJ M1TRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LpdGlEPTB;MD6wO|Q4PSEQvF2= MkG1V2FPT0WU
NCI-H1581 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG5V5lKSzVyPUCuNFc1PzhizszN MnvuV2FPT0WU
U-266 MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WxVGlEPTB;MD6wO|Q6PyEQvF2= NFjKboVUSU6JRWK=
DMS-114 M3XyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHveWZKSzVyPUCuNFc2OjhizszN NWnPUotmW0GQR1XS
NCI-H187 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEe3NlYh|ryP MlPrV2FPT0WU
SW962 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HreWlEPTB;MD6wO|g{QSEQvF2= M3nzeXNCVkeHUh?=
MONO-MAC-6 NYP2RYp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDETWM2OD1yLkC3PVg3KM7:TR?= MmfKV2FPT0WU
MOLT-16 NIHteGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEixNlEh|ryP NIjlS4pUSU6JRWK=
KNS-42 M3f6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHnTWM2OD1yLkC4NVYyKM7:TR?= M1XqWnNCVkeHUh?=
CMK NXzweZVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPlTWM2OD1yLkC4NlI2KM7:TR?= M1nXSXNCVkeHUh?=
Ramos-2G6-4C10 NEWzVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfvb5FKSzVyPUCuNFgzOjVizszN NHvtdmxUSU6JRWK=
Daudi MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnUdHdKSzVyPUCuNFgzPTZizszN MmXLV2FPT0WU
NCI-H510A NHXQbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS0OphKSzVyPUCuNFg{OzZizszN NX22e3kyW0GQR1XS
LB831-BLC NF;2VVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H3OmlEPTB;MD6wPFU3OSEQvF2= NG[4[4FUSU6JRWK=
HEL M3HWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G2dWlEPTB;MD6wPFY3QCEQvF2= MUTTRW5ITVJ?
LU-134-A MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjSTWM2OD1yLkC4O|A5KM7:TR?= NV7ENnU3W0GQR1XS
NCI-H1694 M2\nc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEi3OFQh|ryP M{LkfHNCVkeHUh?=
KGN NFHjWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEi3OVkh|ryP NFy1NndUSU6JRWK=
A253 NG\UO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\zPWlEPTB;MD6wPFgzOiEQvF2= M4iwbXNCVkeHUh?=
DG-75 NInZ[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEi5NlIh|ryP M2LCbXNCVkeHUh?=
MOLT-4 NHPpZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTneI5UUUN3ME2wMlA5QTh|IN88US=> MYPTRW5ITVJ?
NCI-SNU-5 NU\XfoNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEmyOVgh|ryP NXP3WY5pW0GQR1XS
ONS-76 M3Wwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG2cnVIUUN3ME2wMlA6Ojd4IN88US=> NUTMUWdVW0GQR1XS
NCI-H446 M3Lv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPVZZZKSzVyPUCuNFk1PjJizszN MmfjV2FPT0WU
COR-L279 NYDNS4V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrteGdKSzVyPUCuNFk2PTZizszN MYjTRW5ITVJ?
Calu-6 M1zPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\kcnk6UUN3ME2wMlA6PTl6IN88US=> M2TnOHNCVkeHUh?=
BC-3 M{fWO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;3NpBKSzVyPUCuNFk3PjJizszN NIjUNY5USU6JRWK=
NCI-H2126 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1znb2lEPTB;MD6wPVc6OSEQvF2= NHzwdmdUSU6JRWK=
NCI-H1882 MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEm4NFkh|ryP MljBV2FPT0WU
BB65-RCC M17YOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG4coxyUUN3ME2wMlExOjl2IN88US=> NH3HZllUSU6JRWK=
DU-4475 NFrwU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33RbGlEPTB;MD6xNFQxPyEQvF2= NV;sdpRYW0GQR1XS
NCI-H526 M3\RUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O3OmlEPTB;MD6xNFQ1KM7:TR?= MkjoV2FPT0WU
NEC8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMUC1NlUh|ryP MlfUV2FPT0WU
NCI-H1304 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMUC1PVQh|ryP M4nPWHNCVkeHUh?=
L-540 M3rEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2wWFJJUUN3ME2wMlExPzB6IN88US=> NIri[YhUSU6JRWK=
NCI-SNU-16 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nHe2lEPTB;MD6xNFc1OiEQvF2= M4HTd3NCVkeHUh?=
HD-MY-Z MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H4VGlEPTB;MD6xNFg2PiEQvF2= NGDEWXVUSU6JRWK=
K-562 NXvjWmdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vsdGlEPTB;MD6xNFg2QCEQvF2= MnHQV2FPT0WU
JAR M2W0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUC5NlUh|ryP NWDBXIpVW0GQR1XS
MZ2-MEL M{TVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTwfHNKSzVyPUCuNVExPSEQvF2= M{LHbHNCVkeHUh?=
L-363 NYHVRolWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\ITWM2OD1yLkGxNFc6KM7:TR?= NFW4OoZUSU6JRWK=
BV-173 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XKVWlEPTB;MD6xNVI1OyEQvF2= M4fGZXNCVkeHUh?=
NCI-H524 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfKN4pKSzVyPUCuNVEzPzRizszN MXHTRW5ITVJ?
EoL-1-cell NH;Y[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOzVYpKSzVyPUCuNVE3PzJizszN Mlu5V2FPT0WU
K052 NVXlZnVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfjTWM2OD1yLkGxO|EzKM7:TR?= NGq4[GVUSU6JRWK=
TK10 NVrvdnUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XuUGlEPTB;MD6xNVczQCEQvF2= MoWxV2FPT0WU
KU812 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rSXGlEPTB;MD6xNlA1PCEQvF2= NVvEbXAxW0GQR1XS
RPMI-8226 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHXemRwUUN3ME2wMlEzODV{IN88US=> MnTLV2FPT0WU
MZ7-mel MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XwNWlEPTB;MD6xNlI{PyEQvF2= NXnRO|hlW0GQR1XS
SK-PN-DW MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITjeoxKSzVyPUCuNVIzQDdizszN NULs[WdDW0GQR1XS
SR NYPUN3VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITifZNKSzVyPUCuNVI1PDFizszN Mo\jV2FPT0WU
RPMI-6666 NVPMbVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMUK3OFMh|ryP MkfXV2FPT0WU
no-11 NIHSR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLkTWM2OD1yLkGyPFY6KM7:TR?= NWfXXGlPW0GQR1XS
EW-3 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn33TWM2OD1yLkGyPFk{KM7:TR?= NVHQWldPW0GQR1XS
LAMA-84 M2LibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorOTWM2OD1yLkGzNVg4KM7:TR?= NFLvWIJUSU6JRWK=
HT NF7GToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T1bGlEPTB;MD6xN|U4PCEQvF2= NH;aSY1USU6JRWK=
KP-N-RT-BM-1 NULMWVVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofoTWM2OD1yLkGzOlEzKM7:TR?= NVr3b2FUW0GQR1XS
NCI-H747 NUWzSVk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuzVZRoUUN3ME2wMlE{PyEQvF2= NF\FSVJUSU6JRWK=
NCCIT NXraU2w4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXNTWM2OD1yLkGzPVM6KM7:TR?= MWTTRW5ITVJ?
MLMA MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\uSoVKSzVyPUCuNVQyPjdizszN MWfTRW5ITVJ?
LP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHWTWM2OD1yLkG0NlQh|ryP NELsZ3RUSU6JRWK=
CAL-148 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMUS0PFMh|ryP NYXRUYZwW0GQR1XS
GB-1 NG\KOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfqXWRpUUN3ME2wMlE1PTJ4IN88US=> NUDXepVZW0GQR1XS
COR-L88 NXn0U453T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO0TWM2OD1yLkG0PFAzKM7:TR?= NX7QXJd3W0GQR1XS
NKM-1 NX\KdFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXBTWM2OD1yLkG0PVA3KM7:TR?= NXLnNXI{W0GQR1XS
NB5 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jiWmlEPTB;MD6xOVQ3OiEQvF2= NFzneVBUSU6JRWK=
SH-4 NHm3T3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnHdHhCUUN3ME2wMlE2PDZ4IN88US=> MV7TRW5ITVJ?
EM-2 NHXvbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLURmVUUUN3ME2wMlE2PDZ5IN88US=> MVXTRW5ITVJ?
TGBC24TKB NUXOZWRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rlfWlEPTB;MD6xOVY2QSEQvF2= NFPjRoFUSU6JRWK=
SCLC-21H M4m2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf3VotzUUN3ME2wMlE2PzB{IN88US=> MlTwV2FPT0WU
COLO-684 NGXVdXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPOe2JCUUN3ME2wMlE2PzJzIN88US=> M4LuRnNCVkeHUh?=
KINGS-1 NIDOVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMUW5NUDPxE1? MVXTRW5ITVJ?
LS-123 NHLHXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3Db2sxUUN3ME2wMlE2QTF5IN88US=> MYHTRW5ITVJ?
MC116 M2XIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HtN2lEPTB;MD6xOlE2QCEQvF2= NWDxT5FpW0GQR1XS
SU-DHL-1 NFrPbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fNdmlEPTB;MD6xOlIxPiEQvF2= M3;ufnNCVkeHUh?=
NCI-H64 NXXJd|VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID4SHZKSzVyPUCuNVY{PDdizszN MV7TRW5ITVJ?
HCE-T Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfqblVKSzVyPUCuNVY2ODRizszN MlvBV2FPT0WU
LOXIMVI MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17aRmlEPTB;MD6xOlk1QSEQvF2= MWPTRW5ITVJ?
ARH-77 NGjqRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjoTWM2OD1yLkG3N|c6KM7:TR?= NEnLN3VUSU6JRWK=
DOHH-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjFVnNKSzVyPUCuNVc3PzJizszN NIrZToNUSU6JRWK=
COLO-320-HSR NUjvOo5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTmTWM2OD1yLkG4NVU1KM7:TR?= MnrUV2FPT0WU
NB6 M4PnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\IeI1KSzVyPUCuNVg2PjZizszN NHntc|RUSU6JRWK=
L-428 M17aR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUi4NVMh|ryP MX7TRW5ITVJ?
SNB75 NYPZc2t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XNTGlEPTB;MD6xPFgzPCEQvF2= MVTTRW5ITVJ?
NCI-H2141 NUPNS5VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW3TWM2OD1yLkG5NFEyKM7:TR?= MXnTRW5ITVJ?
KARPAS-299 M1\ybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMUmyOFEh|ryP M{LWbnNCVkeHUh?=
LC4-1 NELld5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHITWM2OD1yLkG5OVAzKM7:TR?= M4HDW3NCVkeHUh?=
UACC-257 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HCSmlEPTB;MD6xPVk1PyEQvF2= MluyV2FPT0WU
EVSA-T NEDyfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;wTWM2OD1yLkKwN|EzKM7:TR?= NEOwfWVUSU6JRWK=
JiyoyeP-2003 M33wWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqxTHNRUUN3ME2wMlIxPDd5IN88US=> MWHTRW5ITVJ?
NCI-H720 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn60TWM2OD1yLkKwOVI2KM7:TR?= NIG5PFdUSU6JRWK=
GAK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMkGxPFkh|ryP NEPWXVRUSU6JRWK=
HH MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnhRVNTUUN3ME2wMlIyPDB3IN88US=> MUPTRW5ITVJ?
NCI-H1436 NV24RZEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfTPWRQUUN3ME2wMlIyPDZ2IN88US=> M3y2U3NCVkeHUh?=
GR-ST Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrITWM2OD1yLkKxOFg5KM7:TR?= NYi2TI1oW0GQR1XS
BC-1 M1LVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm4TWM2OD1yLkKyOlE3KM7:TR?= NIe4[mZUSU6JRWK=
SIG-M5 M37pfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG4eJF[UUN3ME2wMlIzPzJ5IN88US=> MmXTV2FPT0WU
NCI-H345 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqz[4hTUUN3ME2wMlI{QDB3IN88US=> NXTCT5o{W0GQR1XS
OPM-2 M2nu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD3TWM2OD1yLkKzPFgzKM7:TR?= NH3rW4RUSU6JRWK=
LB1047-RCC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDu[pdEUUN3ME2wMlI1PDFizszN NUXmSGNYW0GQR1XS
CTB-1 M1zDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrodpVKSzVyPUCuNlQ1QTNizszN NXTafFVTW0GQR1XS
A3-KAW MnfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMkWzOFEh|ryP NUm5PJU3W0GQR1XS
SF126 M1r1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MortTWM2OD1yLkK1N|g{KM7:TR?= MW\TRW5ITVJ?
KARPAS-422 NX33V4Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXyN5hIUUN3ME2wMlI2PDN3IN88US=> M365dXNCVkeHUh?=
MEG-01 NIjXOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW4VJZKSzVyPUCuNlU3PzNizszN M3nufnNCVkeHUh?=
NCI-H209 NHXvWFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS2TZBIUUN3ME2wMlI3Ozd2IN88US=> MX7TRW5ITVJ?
SBC-1 NG[3OIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLFTWM2OD1yLkK2OUDPxE1? Ml7zV2FPT0WU
K5 M1frdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\XV2lEPTB;MD6yOlk5PCEQvF2= M1nWUnNCVkeHUh?=
QIMR-WIL MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SyeWlEPTB;MD6yO|E2PSEQvF2= NEfTNJVUSU6JRWK=
NMC-G1 NFi2NXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PqNmlEPTB;MD6yPFIyPyEQvF2= MnO0V2FPT0WU
IST-MES1 MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHjbXVKSzVyPUCuNlkzOzhizszN M4j1fXNCVkeHUh?=
SW684 M1rPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnQTWM2OD1yLkOwNFQ4KM7:TR?= M1\YNHNCVkeHUh?=
MV-4-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjmTWM2OD1yLkOwO|g5KM7:TR?= MXzTRW5ITVJ?
LAN-6 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rJbWlEPTB;MD6zNVU4OiEQvF2= Mmr1V2FPT0WU
RH-1 NFPWfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVztSoQ3UUN3ME2wMlMyQDdzIN88US=> NV\yVFdqW0GQR1XS
CP66-MEL M3fuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfpTWM2OD1yLkOxPFc5KM7:TR?= NX23UZV5W0GQR1XS
EC-GI-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fCc2lEPTB;MD6zNlk5PyEQvF2= NEfGTIpUSU6JRWK=
GDM-1 NFjkbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLKTWM2OD1yLkOzNFU6KM7:TR?= MUfTRW5ITVJ?
IST-SL1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwM{S5NVQh|ryP M2[0OnNCVkeHUh?=
KMOE-2 M2jKb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwM{WxO|Uh|ryP M1naXnNCVkeHUh?=
OS-RC-2 Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rQeGlEPTB;MD6zOVU1PCEQvF2= MknqV2FPT0WU
HDLM-2 M2\ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwM{e4NVQh|ryP NF;j[ZNUSU6JRWK=
DSH1 NVuxR3JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXyT3dKSzVyPUCuN|g3OzFizszN NI\wcoJUSU6JRWK=
LS-1034 M1\XSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnwfYlSUUN3ME2wMlM5QTV2IN88US=> NVnMSWJDW0GQR1XS
LB373-MEL-D NGjjeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVflV5JwUUN3ME2wMlM6OTl5IN88US=> MmXYV2FPT0WU
GOTO M3XNWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\K[3N5UUN3ME2wMlQzOTF6IN88US=> M1H0fXNCVkeHUh?=
MRK-nu-1 NXPOV|EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfSTWM2OD1yLkSyNlA2KM7:TR?= NFO4NWlUSU6JRWK=
SK-MM-2 Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXzXWduUUN3ME2wMlQ{PDR{IN88US=> Mn[1V2FPT0WU
BOKU NGTjWnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G2PGlEPTB;MD60N|c6OiEQvF2= MXHTRW5ITVJ?
NOMO-1 NIroVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjDbXVuUUN3ME2wMlQ{QDZizszN M33RTnNCVkeHUh?=
J-RT3-T3-5 NXP0RWlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;td2lEPTB;MD60OFg4QCEQvF2= M2P1SnNCVkeHUh?=
COLO-668 NVPCRmtzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPOTWM2OD1yLkS1OlY5KM7:TR?= MYXTRW5ITVJ?
SF539 NEPpfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNEi2PFQh|ryP NX3RVJdnW0GQR1XS
LB2518-MEL M1rWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn72TWM2OD1yLkS5O|A{KM7:TR?= NYXYNItkW0GQR1XS
TE-441-T NX7oTo12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwNUCxNkDPxE1? M2XiU3NCVkeHUh?=
MDA-MB-134-VI MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:yVIpKUUN3ME2wMlUxQTJzIN88US=> NXXzUIxFW0GQR1XS
SCC-3 NVHrV3VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC0eoVKSzVyPUCuOVE5PzNizszN MkL2V2FPT0WU
KLE NY[5bHFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XJW2lEPTB;MD61NlE4OSEQvF2= NGH1Om9USU6JRWK=
LB2241-RCC MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPuW3lKSzVyPUCuOVI2OjVizszN MWXTRW5ITVJ?
NCI-H1417 NI\5eI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37DR2lEPTB;MD61N|Q{PSEQvF2= M12xd3NCVkeHUh?=
NCI-H2081 MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDteHpKSzVyPUCuOVg3OTFizszN MVTTRW5ITVJ?
NCI-H1522 NWPGRZA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjKcW52UUN3ME2wMlU6Ozh|IN88US=> M4XsOnNCVkeHUh?=
NCI-H889 NFyzcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfnW|ZKSzVyPUCuOVk5PDRizszN MoLqV2FPT0WU
CGTH-W-1 M4TJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDzPJNKSzVyPUCuOlA4PTVizszN NUfiVYJRW0GQR1XS
EB-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLmTWM2OD1yLk[xNVU{KM7:TR?= NF31U|VUSU6JRWK=
D-336MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwNkG3PVEh|ryP MV3TRW5ITVJ?
LC-1F NIjySllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvRVI9sUUN3ME2wMlYzPTl{IN88US=> M2jq[3NCVkeHUh?=
MHH-NB-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\PbWlEPTB;MD62N|gxOSEQvF2= MkPVV2FPT0WU
SK-N-FI NXzDSnVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3TTWM2OD1yLk[zPVEh|ryP MV3TRW5ITVJ?
NCI-H69 NXXOe41sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHobHF{UUN3ME2wMlY1QDd7IN88US=> NXnPRZp1W0GQR1XS
SCH M1LFR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTXeJdxUUN3ME2wMlY3ODJ|IN88US=> M{XOSXNCVkeHUh?=
LS-513 M3LpTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHI[2QxUUN3ME2wMlY4OjV7IN88US=> MYDTRW5ITVJ?
CP67-MEL NI\hXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNke1PVYh|ryP NILJTI5USU6JRWK=
GCIY NGDWbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnme456UUN3ME2wMlcxOzZ|IN88US=> NYXGXYFCW0GQR1XS
SHP-77 M2HOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XP[GlEPTB;MD63NFc{PCEQvF2= NFfETHZUSU6JRWK=
EHEB MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHxTWM2OD1yLkexPFU1KM7:TR?= NYW1cXF[W0GQR1XS
D-247MG NGPvOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP1UXFKUUN3ME2wMlc{OjN{IN88US=> M4DnTXNCVkeHUh?=
Raji MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;OWHpCUUN3ME2wMlc1QTh7IN88US=> NHz3XnJUSU6JRWK=
MPP-89 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu4V41KSzVyPUCuO|U6PzhizszN M4S5RXNCVkeHUh?=
EKVX NFfjVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwN{mwO|Mh|ryP MUDTRW5ITVJ?
HCC2218 NGT1dXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTBTWM2OD1yLke5NVMyKM7:TR?= NYCzflhSW0GQR1XS
KNS-81-FD MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwOEGwNVEh|ryP NU\4Z2ZiW0GQR1XS
HCC2157 NV7qPGlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTQTWM2OD1yLki0PVUyKM7:TR?= NGfn[VhUSU6JRWK=
BT-474 NUTJfodlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vVZ2lEPTB;MD64PFg2PCEQvF2= Mo\yV2FPT0WU
NCI-H748 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvPGlEPTB;MD65NVIh|ryP NHP5ZZlUSU6JRWK=
EW-24 NF;xOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTKTWM2OD1yLkmyNFAzKM7:TR?= NHeyS2dUSU6JRWK=
D-263MG NGTBelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H1T2lEPTB;MD65OFUyOiEQvF2= MX\TRW5ITVJ?
OMC-1 NWDkdIVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjqbnhKSzVyPUCuPVY{PzNizszN NFfNNZZUSU6JRWK=
NCI-H2196 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Cem1KSzVyPUCuPVc4PzdizszN NWXYWZozW0GQR1XS
HAL-01 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPxW2o1UUN3ME2wMlk6QDd{IN88US=> Mnv6V2FPT0WU
NCI-H2107 NVLmSphiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPwbGV3UUN3ME2xMlAyQDV2IN88US=> M3u3cnNCVkeHUh?=
LB996-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjQZYdqUUN3ME2xMlA5ODVzIN88US=> NGXnRYdUSU6JRWK=
NCI-H1395 NGHwSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnhTotqUUN3ME2xMlExPjdizszN NGHvUWdUSU6JRWK=
CHP-126 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET6endKSzVyPUGuNVYyQTlizszN NYO2fmVqW0GQR1XS
NB69 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XrVGlEPTB;MT6yOlE1QCEQvF2= MXvTRW5ITVJ?
CAS-1 MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLMUVJRUUN3ME2xMlM1OjNzIN88US=> NF;jO5dUSU6JRWK=
JVM-3 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTMXVJjUUN3ME2xMlQ4QDV3IN88US=> NWPOeYNmW0GQR1XS
DMS-153 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[5[o9FUUN3ME2xMlU4Pjd2IN88US=> Mnz0V2FPT0WU
SK-MEL-2 MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;J[2lEPTB;MT63NVc5QSEQvF2= M3jWVnNCVkeHUh?=
NCI-H1155 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7OSJNKSzVyPUGuO|M3PzZizszN M{DGVXNCVkeHUh?=
NCI-H1092 NWnFN|I1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwN{[xPFIh|ryP MlHMV2FPT0WU
LU-165 NEPJS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXaTnpVUUN3ME2xMlg3PDd4IN88US=> MoDvV2FPT0WU
HL-60 M334fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDSWWJMUUN3ME2xMlk6QTB6IN88US=> NEHDTXFUSU6JRWK=
REH M1rXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPa[W9KSzVyPUKuNFA2QDJizszN NWnpfWVLW0GQR1XS
JVM-2 MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\GTWM2OD1{LkC2NVM2KM7:TR?= MlrwV2FPT0WU
MN-60 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTTUnN1UUN3ME2yMlE4OzB6IN88US=> NGj5OXlUSU6JRWK=
SCC-15 M3;scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfXS5RqUUN3ME2yMlIxOjdizszN Mle3V2FPT0WU
SNU-C1 NYnFd|NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHicmFKSzVyPUKuNlE{PDNizszN NV;xRXplW0GQR1XS
SK-MEL-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[5V25KSzVyPUKuN|IxPDdizszN MX3TRW5ITVJ?
TGW NG\X[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfhe4tlUUN3ME2yMlM2ODJ5IN88US=> M3XEVnNCVkeHUh?=
CA46 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TGU2lEPTB;Mj63OVk3PyEQvF2= Ml7HV2FPT0WU
NCI-H23 NWm1TIVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWzXVJKSzVyPUKuPFA4QTFizszN MorTV2FPT0WU
MMAC-SF NYXZU2JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTiZXhMUUN3ME2yMlg3PjJ6IN88US=> M3vRfHNCVkeHUh?=
NCI-H2171 NXvZb|ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzyfY11UUN3ME2zMlA{PDR6IN88US=> NIrXOFRUSU6JRWK=
A704 MlPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[xb2lEPTB;Mz6xOFE6PCEQvF2= MVzTRW5ITVJ?
DB M{fuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L3W2lEPTB;Mz6yOVU4PiEQvF2= MWTTRW5ITVJ?
NCI-H719 M4XQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwM{CzPFQh|ryP NHfWTnJUSU6JRWK=
MC-CAR MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;ZcI5KSzVyPUOuOVQ5OTdizszN MoXEV2FPT0WU
SIMA NGrvTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfJTWM2OD1|LkW4OFE3KM7:TR?= Mn;KV2FPT0WU
SW872 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojxTWM2OD1|Lke4NVAyKM7:TR?= NH7SNGpUSU6JRWK=
HCC1187 NYXmfW1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXGTWM2OD1|Lke4N|E2KM7:TR?= NYfCSoxXW0GQR1XS
EW-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrUTWM2OD1|LkizOFE4KM7:TR?= NFmwZYlUSU6JRWK=
NCI-SNU-1 M4Wybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnFXHY{UUN3ME20MlIyQTl7IN88US=> MXXTRW5ITVJ?
NCI-H226 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTvZZpKSzVyPUSuN|M3ODZizszN M320S3NCVkeHUh?=
RPMI-8866 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojSTWM2OD12LkO2NFI6KM7:TR?= NFrKOYlUSU6JRWK=
OCI-AML2 M{fDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTRwNUWyN{DPxE1? MmPqV2FPT0WU
LU-65 NIXDe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHKTWM2OD12LkmzNFM{KM7:TR?= NW\XcGkyW0GQR1XS
SK-N-DZ MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWyRpNKSzVyPUWuOlM1PjVizszN NVzYTlBMW0GQR1XS
NB14 NUXNTXVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILGNGhKSzVyPUWuPVcyOzVizszN NE\jPZpUSU6JRWK=
COLO-829 NFjKVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTZwM{OzOVkh|ryP NFjxPXFUSU6JRWK=
MHH-CALL-2 NYDKOYNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPXXIpKSzVyPU[uOVE2ODhizszN MkLNV2FPT0WU
NCI-H1770 NI\Qc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPGTWM2OD14Lk[2PVA1KM7:TR?= M37CTnNCVkeHUh?=
ECC4 NUW3Z2FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTZwOEKxO|kh|ryP Ml\OV2FPT0WU
A498 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vtSGlEPTB;Nj64O|E6OiEQvF2= MoTtV2FPT0WU
DMS-79 NHPXUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfUTWM2OD15LkC0OVEzKM7:TR?= NIn0VWJUSU6JRWK=
P30-OHK NUO1fZV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzRd3BKSzVyPUeuNlE6ODZizszN NYfwN3Q2W0GQR1XS
D-502MG MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS5TWM2OD15Lkm4N|Yh|ryP NHjvZ3FUSU6JRWK=
RCC10RGB Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\DNJlKSzVyPUiuNFYzQCEQvF2= Mln5V2FPT0WU
U-698-M Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnToTWM2OD16LkK5NlI3KM7:TR?= NWDkXlJrW0GQR1XS
BB49-HNC M4fHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rJS2lEPTB;OT60NlI3PSEQvF2= MmfkV2FPT0WU
ES1 NHnTR3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTlwNki5OVYh|ryP MU\TRW5ITVJ?
MFM-223 NWDPTZNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFyLkm5Nlch|ryP MnHZV2FPT0WU
C2BBe1 M2Djc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;GTWM2OD1zMT6zOVI{KM7:TR?= MV;TRW5ITVJ?
EB2 MljiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\uZoxKSzVyPUGyMlY5QDFizszN MYLTRW5ITVJ?
C8166 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nK[GlEPTB;MUOuPFMxOyEQvF2= MWnTRW5ITVJ?
ES3 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPDPFNKSzVyPUGzMlk6PzdizszN M{\E[HNCVkeHUh?=
NCI-H1650 M3y2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPHU2RzUUN3ME2xOk4{PzZ3IN88US=> NGPxe4NUSU6JRWK=
Mo-T NHjJS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLhfYd4UUN3ME2xO{41ODJ7IN88US=> M{Gx[HNCVkeHUh?=
NB7 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLyTWM2OD1zNz63OFY4KM7:TR?= NHHWbYtUSU6JRWK=
ES7 MkLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrJXoZvUUN3ME2xPU42PTB5IN88US=> MkjlV2FPT0WU
ES5 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX35NHliUUN3ME2yNU44PjdzIN88US=> NFPXSG5USU6JRWK=
MSTO-211H MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHCVpBKSzVyPUKxMlg5PThizszN M3rWe3NCVkeHUh?=
U-87-MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLiTWM2OD1{NT6xPVY3KM7:TR?= MYLTRW5ITVJ?
THP-1 M3j6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfmXpNKSzVyPUK5MlczODFizszN M{PleXNCVkeHUh?=
NB10 M3rzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTNyLkK2PVQh|ryP MkLXV2FPT0WU
NH-12 NELyXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7PTWM2OD1|Mz6yNFE4KM7:TR?= NGP1VHNUSU6JRWK=
COLO-824 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWxTWM2OD1|ND6xNFA3KM7:TR?= M1v6WXNCVkeHUh?=
SKM-1 NWf4SXJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrPTlZKSzVyPUO3Mlg1OjJizszN NX31XW05W0GQR1XS
NCI-H1838 NEDPWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\DTWM2OD1|OD6zO|k4KM7:TR?= NXTIOY1iW0GQR1XS
RL M2Hmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv3eppKSzVyPUO5MlI1PzdizszN NEDXXVFUSU6JRWK=
COLO-800 NHmybZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnaTWM2OD12MD6wO|c{KM7:TR?= MXzTRW5ITVJ?
KG-1 M1PaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRyLki5OVUh|ryP NUDUT3ZsW0GQR1XS
TUR MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTRzLk[zPVkh|ryP NVHqUVBxW0GQR1XS
LNCaP-Clone-FGC MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTRzLkmwNVch|ryP M{jEUHNCVkeHUh?=
NCI-H322M MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR{LkW5PFQh|ryP MUfTRW5ITVJ?
LNCaP  NYnNS4JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\uTWM2OD17MT6zJI5O M2HzeFI2PTB3MUe0
C4-2 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjwVYVKSzVyPUigcm0> NYTJeoQ2OjV3MEWxO|Q>
JURKAT NXHDVFI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzzNlQhcA>? NYDyUHEyUUN3ME20NVYvPjZibl2= NH3HR|gzPDVzOUm5OS=>
MOLT-4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLqNlQhcA>? MVfJR|UxRTJ6NUOuOUBvVQ>? M3nYdVI1PTF7OUm1
REH MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHqNlQhcA>? MYjJR|UxRTJ6Nz62PEBvVQ>? MVeyOFUyQTl7NR?=
NALM-6 M1u2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnNVpQ{OjRiaB?= MWHJR|UxRTN2M{OwJI5O MUCyOFUyQTl7NR?=
RS 4;11 NWDlT5gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqyOEBp NYjBXJVZUUN3ME21NVkvODVibl2= M1XFW|I1PTF7OUm1
697 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXUNlQhcA>? Mn7KTWM2OD1{MUC3MlEhdk1? MX2yOFUyQTl7NR?=
SIL-ALL NGXwWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknmNlQhcA>? Mof2TWM2OD1zOUmuO|chdk1? NF\N[XEzPDVzOUm5OS=>
CEM NWGxbplKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPreFhDOjRiaB?= NI\xfYxKSzVyPUWyMlE5KG6P NYr0bGJXOjR3MUm5PVU>
P12 NUHR[5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPZNlQhcA>? MnnQTWM2OD1|OT6yO{BvVQ>? MmXZNlQ2OTl7OUW=
NALM-16 NUnXVm15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXmNXRrOjRiaB?= M1jxS2lEPTB;OU[uNlghdk1? NWPKZoc{OjR3MUm5PVU>
JURKAT M3nMdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnO1OFghcA>? Mn7OTWM2OD1zND64OEBvVQ>? NFLhfGMzPDVzOUm5OS=>
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WER-Rb-1 M2HvSWFxd3C2b4Ppd{BCe3OjeR?= NV:3dI9tOS13MDDuUS=> MXmxNk8zPCCq M{OzVmROW09? MU\pcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= NFfBOoUzPDN4Nk[2OS=>
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CB660 NHLMXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTZwNDDuUS=> MVGyOFIxPDd|Mx?=
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KB-3-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;rOHVKSzVyPUGuOFghyrFiMD61N{BvVQ>? M4\Q[|I{QTZ{NES1
KB-8-5-11 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X5NmlEPTB;NT6wNUDDuSB{LkCxJI5O NV;3[mg1OjN7NkK0OFU>
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OVCAR-8 NGC3UXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTdwMUmgxtEhOy54MDDuUS=> NELhZ3gzOzl4MkS0OS=>
NCI-ADR-RES MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF{N{OuN|AhyrFiMUmxMlIxKG6P NEHoRoczOzl4MkS0OS=>
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CORL-23/R NUfBOlNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3VTWM2OD13LkG2JOKyKDFwOEOgcm0> NHvSdWEzOzl4MkS0OS=>
NIH3T3 NYPrfpJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTRyLk[wJOKyKDRwOUegcm0> NGjXbpMzOzl4MkS0OS=>
NIH3T3-G185 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn1fldnUUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> Ml[wNlM6PjJ2NEW=
pcDNA-HEK293 NEPNbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwN{WgxtEhOC54NzDuUS=> M1PifVI{QTZ{NES1
MDR19-HEK293 NH7WWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jRRmlEPTB;OEWuOVAhyrFiMUOuOlchdk1? MYOyN|k3OjR2NR?=
R482-HEK293 NIGzT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmwRlJKSzVyPUK1Mlk4KMLzIESuPVUhdk1? NFfJZY0zOzl4MkS0OS=>
MRP1-HEK293 NGD6c2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJwOUmgxtEhOS52OTDuUS=> MVyyN|k3OjR2NR?=
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LNCaP  MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vjd2ROW09? M1;MTGlEPTEkiMy3OUBvVQ>? NYT3fmR5OjN6OES0Nlg>
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T24 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TXcGlEPTB;N{muNVIhdk1? MUWyN|c6OjZ|OR?=
MCF7  Mm[xSpVv[3Srb36gRZN{[Xl? NYr1N2FmOTByIH7N MoG0NUBp MXjEUXNQ M37a[JJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZtMgS5Jm[jFuwrDT[4syNMLiUIOyMOKhW2W{cHnuZVMtKGGwZNMgW4l{eDJ? MljGNlM4PzB{NES=
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Caki-1 M2rQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorrOU05OCCwTR?= M1r3S|k3KGh? M3fs[WhEdA>? NUO5dXEze3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N M{fBXFIyPjR{M{e0
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HMC-1.1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nVZlEuOTByMDDuUS=> MlqzO|IhcA>? MlfLbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m NGTWN40zOTJ2MkG4PS=>
HMC-1.2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxMVExODBibl2= NHO2bnA4OiCq NH3S[GNqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? Mn[yNlEzPDJzOEm=
C2 NHfR[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH64coUyNTFyMECgcm0> NETLV|M4OiCq MnTIbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m MlfXNlEzPDJzOEm=
CHP-212 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETVfFQyNTF{NTDuUS=> MkDuNlQuOTJyIHi= M1;DXIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NXTGcpRkOjFzNkmyOFI>
IMR-32 M33KUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxMVEzPSCwTR?= MkexNlQuOTJyIHi= NFzq[mlqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MU[yNVE3QTJ2Mh?=
Kelly NYHOR4FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexMVEzPSCwTR?= MYmyOE0yOjBiaB?= Mn7zbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NEjQemgzOTF4OUK0Ni=>
SH-EP MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz2NU0yOjVibl2= Mnj1NlQuOTJyIHi= NITReIRqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M2TOO|IyOTZ7MkSy
SH-SY5Y NUfUbohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3DUo4yNTF{NTDuUS=> MkPTNlQuOTJyIHi= MYLpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MUGyNVE3QTJ2Mh?=
SK-N-AS MoflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;mNU0yOjVibl2= NYXSb4U{OjRvMUKwJIg> MnvSbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MY[yNVE3QTJ2Mh?=
SK-N-BE NWHq[FBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XwTVEuOTJ3IH7N NETZZlkzPC1zMkCgbC=> M1i2WIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NFPvbVgzOTF4OUK0Ni=>
KG1 NVPW[mVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XmOlEwOTBxMUCwJI5O M3LOT|czKGh? NGDMNFVFVVOR MYLpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MoHENVk1PTh|NUi=
U937 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfUNU8yOC9zMECgcm0> MoPaO|IhcA>? NV\xbo17TE2VTx?= NEPmdItqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NXHsc4ZXOTl2NUizOVg>
CAL62 M3K0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;WNE4yNTFyMDDuUS=> Mnn1O|IhcA>? MnT2SG1UVw>? NX7kN3hTTUN3ME2xMlQhdk1? MVuxPVIzOzV3Mx?=
OCUT-1 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqwMlEuOTByIH7N NFLmfVE4OiCq MmrlSG1UVw>? M1\NUmVEPTB;Mj6zJI5O NHvKTVcyQTJ{M{W1Ny=>
8505C MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILUc4kxNjFvMUCwJI5O NFLpXlI4OiCq M1nBRWROW09? Mn63SWM2OD1|LkKgcm0> NH3wOIQyQTJ{M{W1Ny=>
ACT-1 NXvDb4M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jIPVAvOS1zMECgcm0> Mk\IO|IhcA>? MWnEUXNQ MoT0SWM2OD13LkSgcm0> M3XKW|E6OjJ|NUWz
SW1736 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSwMlEuOTByIH7N MlPGO|IhcA>? NVPUVmZOTE2VTx?= Mo\4SWM2OD13Lk[gcm0> MoTVNVkzOjN3NUO=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID