BI 2536

For research use only.

Catalog No.S1109

200 publications

BI 2536 Chemical Structure

CAS No. 755038-02-9

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

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10mM (1mL in DMSO) RMB 1978.87 In stock
RMB 981.57 In stock
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Selleck's BI 2536 has been cited by 200 publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
c-Myc [3]
()
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
BRD4 [3]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 37 nM(Kd)
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXwbINTUUN3ME2wMlAxPzd4IN88US=> MlX1V2FPT0WU
ACN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rUNGlEPTB;MD6wNFg1OyEQvF2= MX3TRW5ITVJ?
TE-8 NUHDcG55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfzNGZKSzVyPUCuNFA6PDFizszN NF\TVYlUSU6JRWK=
LC-2-ad Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES4bZBKSzVyPUCuNFExQTNizszN Mn\GV2FPT0WU
ALL-PO M2f3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS4VmRZUUN3ME2wMlAyOyEQvF2= MnPqV2FPT0WU
EW-16 M4f1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHpN2FKSzVyPUCuNFE{OzZizszN NXSx[GE4W0GQR1XS
KM12 NHPjTJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLVT|lKUUN3ME2wMlAyOzR6IN88US=> NH;2NWxUSU6JRWK=
GI-1 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPKN4liUUN3ME2wMlAyOzh|IN88US=> NXfFWo91W0GQR1XS
LS-411N M1Tkbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHqVFRKSzVyPUCuNFE1ODdizszN M33mb3NCVkeHUh?=
ES8 NXvPelR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT2eJZyUUN3ME2wMlAyPDl2IN88US=> MnHCV2FPT0WU
SNU-C2B NVfPcGkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rBWWlEPTB;MD6wNVUzPiEQvF2= M4mzeXNCVkeHUh?=
CESS NEHVO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\VTWM2OD1yLkCxOlAzKM7:TR?= NHzqN|dUSU6JRWK=
697 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml24TWM2OD1yLkCxOlY5KM7:TR?= MUjTRW5ITVJ?
NCI-H1963 NVGyR21sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLjTWM2OD1yLkCxOlc{KM7:TR?= MlvDV2FPT0WU
IA-LM MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jJZWlEPTB;MD6wNVY5QCEQvF2= NWjLW3NuW0GQR1XS
SW954 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T3emlEPTB;MD6wNVcxPSEQvF2= NWryNXBoW0GQR1XS
RL95-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTpTWM2OD1yLkCxO|M5KM7:TR?= M2TNeHNCVkeHUh?=
LXF-289 NXPyXFBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEG3O{DPxE1? NVTwSGFJW0GQR1XS
OCUB-M MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEG4NlYh|ryP NGm2U5ZUSU6JRWK=
RKO MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEG5PFch|ryP NYDKb3JPW0GQR1XS
LOUCY NFnTSVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXQTWM2OD1yLkCyNFUh|ryP MXzTRW5ITVJ?
NOS-1 NEjrOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSwTFRTUUN3ME2wMlAzODl|IN88US=> MUfTRW5ITVJ?
A4-Fuk MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTBXo1yUUN3ME2wMlAzOjF6IN88US=> NFvzSZRUSU6JRWK=
A388 M2m4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX2TWM2OD1yLkCyNlI4KM7:TR?= NUTTdphIW0GQR1XS
TE-9 M{XXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf2Z4pKSzVyPUCuNFIzPjFizszN NW\4WphuW0GQR1XS
KURAMOCHI MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPUdZNKSzVyPUCuNFIzQDVizszN MlLZV2FPT0WU
KALS-1 NET2SYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmyTWM2OD1yLkCyN|M5KM7:TR?= NVjROYdnW0GQR1XS
HOP-62 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S0eWlEPTB;MD6wNlQzKM7:TR?= NGmze4pUSU6JRWK=
RPMI-8402 NFP5U5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrLTWM2OD1yLkCyOVA5KM7:TR?= M4fNb3NCVkeHUh?=
TE-1 NYnoVWxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiwPWZKSzVyPUCuNFI2OTJizszN MojYV2FPT0WU
CCRF-CEM NIi2VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEK1OFMh|ryP NX\QTJp2W0GQR1XS
HUTU-80 NVq5VHdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jXeWlEPTB;MD6wNlYzPCEQvF2= M1\uNnNCVkeHUh?=
NCI-H1648 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33jSWlEPTB;MD6wNlY1PyEQvF2= MmLnV2FPT0WU
HCE-4 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEK2PFIh|ryP MnHVV2FPT0WU
ETK-1 NEHnd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jyeGlEPTB;MD6wNlc{PiEQvF2= NYe2ZY14W0GQR1XS
TE-15 NUXOT45DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEK3N|gh|ryP MVrTRW5ITVJ?
BE-13 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEK3OEDPxE1? MoDmV2FPT0WU
KE-37 NHzBXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWxTWM2OD1yLkCyO|QyKM7:TR?= MkTYV2FPT0WU
NCI-H1355 NFLsemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L2SGlEPTB;MD6wNlc5OyEQvF2= NHvpb2JUSU6JRWK=
TE-11 Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;STWM2OD1yLkCyPFA6KM7:TR?= MVfTRW5ITVJ?
BL-70 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEK4OVch|ryP MmfuV2FPT0WU
ES6 M1j6Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHhRodKSzVyPUCuNFI5QDFizszN NYPpfWEyW0GQR1XS
GT3TKB MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTZWHRFUUN3ME2wMlAzQTV|IN88US=> NWXUcnVYW0GQR1XS
LB647-SCLC NVO0ZolKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3ZcWprUUN3ME2wMlA{OTl3IN88US=> MnS5V2FPT0WU
NB13 NVnoVo9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrwfoZKSzVyPUCuNFM{OTZizszN NY\mN5A5W0GQR1XS
ST486 M{fzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;pVZd3UUN3ME2wMlA{OzN5IN88US=> NF[5fVRUSU6JRWK=
NCI-H82 M2nSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTxTWM2OD1yLkCzN|Q{KM7:TR?= NVG2PIdzW0GQR1XS
NTERA-S-cl-D1 NX:ycGNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;ITWM2OD1yLkCzN|k6KM7:TR?= NEfFe41USU6JRWK=
ES4 NYfVd21sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf3TW1KSzVyPUCuNFM1PjNizszN MnzkV2FPT0WU
SK-NEP-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXWTFJRUUN3ME2wMlA{PDl7IN88US=> MkG3V2FPT0WU
Becker MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEO1OVUh|ryP M1GzTnNCVkeHUh?=
A101D NYfFXpV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HRVGlEPTB;MD6wN|c1QCEQvF2= NV3tRmN3W0GQR1XS
SK-UT-1 NYDmR5U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH6TWM2OD1yLkCzO|c1KM7:TR?= NIfQSJFUSU6JRWK=
SW982 NF:yWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPzTWM2OD1yLkCzO|kh|ryP NV\6dWhPW0GQR1XS
TE-10 NULaeW5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi4SZozUUN3ME2wMlA1ODR4IN88US=> MUHTRW5ITVJ?
OVCAR-4 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLXTWM2OD1yLkC0NFU6KM7:TR?= NV7KZ|VTW0GQR1XS
KP-N-YS MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHJZYhKSzVyPUCuNFQxQDVizszN NX7ZTIM{W0GQR1XS
BL-41 NFL3N5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3LNWZ4UUN3ME2wMlA1OTJ3IN88US=> NFe0TGhUSU6JRWK=
MZ1-PC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTKU5NFUUN3ME2wMlA1OTJ5IN88US=> M1nZfHNCVkeHUh?=
PF-382 NYfsXYNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLENpJKSzVyPUCuNFQyQThizszN NVnvUIRLW0GQR1XS
MOLT-13 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMESyN|gh|ryP NFTrUZVUSU6JRWK=
HCC1599 MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PofWlEPTB;MD6wOFI2QCEQvF2= NIjWXmlUSU6JRWK=
IST-MEL1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXyTWM2OD1yLkC0OFQzKM7:TR?= NVruVndiW0GQR1XS
LU-139 M1HsZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr5TWM2OD1yLkC0OFQzKM7:TR?= NV3YcINJW0GQR1XS
MS-1 M{XEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH75W4RKSzVyPUCuNFQ4ODFizszN Ml;MV2FPT0WU
MFH-ino NWnjRlBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljHTWM2OD1yLkC1NFA{KM7:TR?= NEXkNmZUSU6JRWK=
IMR-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf4XY5MUUN3ME2wMlA2ODJzIN88US=> MkPUV2FPT0WU
TE-5 NGfMTXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEWwOlMh|ryP M2nBe3NCVkeHUh?=
DJM-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj1OZFSUUN3ME2wMlA2OTR{IN88US=> NE\4WmdUSU6JRWK=
NB17 NGrNdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEWyNFch|ryP NFv5TWlUSU6JRWK=
KARPAS-45 NFfrfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml72TWM2OD1yLkC1N|U5KM7:TR?= NF7pc|RUSU6JRWK=
TGBC1TKB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES2W5lKSzVyPUCuNFU1ODVizszN Mnf0V2FPT0WU
ML-2 Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r6W2lEPTB;MD6wOVQyPCEQvF2= MVjTRW5ITVJ?
no-10 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf0[|J3UUN3ME2wMlA2PDd2IN88US=> M{DndHNCVkeHUh?=
CTV-1 NWC1UJpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHmNXk5UUN3ME2wMlA2PTB{IN88US=> Mlq2V2FPT0WU
SJSA-1 NWjHS|NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXPXlJKSzVyPUCuNFU2OiEQvF2= Ml\nV2FPT0WU
HC-1 M4nqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OwNmlEPTB;MD6wOVU6PyEQvF2= M2TTc3NCVkeHUh?=
TE-12 NEfwdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHRW3Z6UUN3ME2wMlA2PjF|IN88US=> MnGxV2FPT0WU
KY821 M4rnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS2b41KSzVyPUCuNFU3OzJizszN MnfXV2FPT0WU
TALL-1 M3fWXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzBTWM2OD1yLkC1O|A5KM7:TR?= MVzTRW5ITVJ?
DEL NWLSc21GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7a[YdjUUN3ME2wMlA2PzB7IN88US=> MmHZV2FPT0WU
TE-6 NXPCWXJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG3fpFKSzVyPUCuNFU4OjJizszN NXvVUIlXW0GQR1XS
SK-LMS-1 NFXYVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\pXWlEPTB;MD6wOVgxPSEQvF2= NWW4W45[W0GQR1XS
EW-1 M{fFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfqXllCUUN3ME2wMlA2QDN5IN88US=> Mo\KV2FPT0WU
8-MG-BA MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XDR2lEPTB;MD6wOVg2OSEQvF2= MnTrV2FPT0WU
NALM-6 M1XUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfUTWM2OD1yLkC1PVc{KM7:TR?= M{n0c3NCVkeHUh?=
LB771-HNC NXjscFlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXk[YNsUUN3ME2wMlA2QTd7IN88US=> NIm2UXZUSU6JRWK=
HT-144 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nMWmlEPTB;MD6wOlE{KM7:TR?= NFfj[|BUSU6JRWK=
KM-H2 NIWwcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H0[GlEPTB;MD6wOlIzOSEQvF2= M4PRPHNCVkeHUh?=
SF268 NX;nc2h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv3TWM2OD1yLkC2Nlg3KM7:TR?= NEDOTVdUSU6JRWK=
RS4-11 NGjRRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7vUYdqUUN3ME2wMlA3OzB2IN88US=> NID6eGVUSU6JRWK=
MHH-PREB-1 NGLxdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwME[zNVkh|ryP NE[1[WdUSU6JRWK=
ATN-1 NWTS[5Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTh[2VFUUN3ME2wMlA3OzR3IN88US=> MoThV2FPT0WU
BB30-HNC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwME[0N|Yh|ryP M{XES3NCVkeHUh?=
CPC-N M{nGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvrPWdKSzVyPUCuNFY2OjRizszN MlnVV2FPT0WU
NB1 NILtR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorETWM2OD1yLkC2OlE{KM7:TR?= M3nWRXNCVkeHUh?=
KS-1 NVTGPGk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\hRmRKSzVyPUCuNFY4PDhizszN MYXTRW5ITVJ?
RXF393 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2foOGlEPTB;MD6wOlc3PCEQvF2= MXvTRW5ITVJ?
IST-SL2 NX\zSmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D5eGlEPTB;MD6wO|AxPCEQvF2= NG\iUoJUSU6JRWK=
GI-ME-N MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfjTWM2OD1yLkC3Nlg3KM7:TR?= MUjTRW5ITVJ?
VA-ES-BJ NX;mfHRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPwbZdKSzVyPUCuNFc1PzVizszN MoPFV2FPT0WU
NCI-H1581 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEe0O|gh|ryP MV3TRW5ITVJ?
U-266 NFzPWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LOWGlEPTB;MD6wO|Q6PyEQvF2= M{L3NHNCVkeHUh?=
DMS-114 NHnzN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjJTWM2OD1yLkC3OVI5KM7:TR?= M1HVWHNCVkeHUh?=
NCI-H187 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1va[mlEPTB;MD6wO|czPiEQvF2= MkLaV2FPT0WU
SW962 NIPDTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrrPYJqUUN3ME2wMlA4QDN7IN88US=> NImxWnZUSU6JRWK=
MONO-MAC-6 M4n5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XqU2lEPTB;MD6wO|k5PiEQvF2= MXzTRW5ITVJ?
MOLT-16 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX6TWM2OD1yLkC4NVIyKM7:TR?= MX7TRW5ITVJ?
KNS-42 NYi0cYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvuTWM2OD1yLkC4NVYyKM7:TR?= Mk[3V2FPT0WU
CMK MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEiyNlUh|ryP MXrTRW5ITVJ?
Ramos-2G6-4C10 NXflPZZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\BeWlEPTB;MD6wPFIzPSEQvF2= NUntfWx1W0GQR1XS
Daudi Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X3ZWlEPTB;MD6wPFI2PiEQvF2= NFzDRYhUSU6JRWK=
NCI-H510A NHfLO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfMW49KSzVyPUCuNFg{OzZizszN M2[3eXNCVkeHUh?=
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TE-441-T M2LoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrMTWM2OD1yLkWwNVIh|ryP M3fhfnNCVkeHUh?=
MDA-MB-134-VI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3oVpBKSzVyPUCuOVA6OjFizszN M3PM[XNCVkeHUh?=
SCC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjS[GZKSzVyPUCuOVE5PzNizszN NXHIUow1W0GQR1XS
KLE MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNUKxO|Eh|ryP MVPTRW5ITVJ?
LB2241-RCC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu5eohKSzVyPUCuOVI2OjVizszN M33CRnNCVkeHUh?=
NCI-H1417 NWfNN4dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT1TWM2OD1yLkWzOFM2KM7:TR?= M37ZOHNCVkeHUh?=
NCI-H2081 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWryUIFbUUN3ME2wMlU5PjFzIN88US=> NXnRXGk5W0GQR1XS
NCI-H1522 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNUmzPFMh|ryP MX3TRW5ITVJ?
NCI-H889 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TlOWlEPTB;MD61PVg1PCEQvF2= M2fCW3NCVkeHUh?=
CGTH-W-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PacWlEPTB;MD62NFc2PSEQvF2= MnvaV2FPT0WU
EB-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwNkGxOVMh|ryP MXPTRW5ITVJ?
D-336MG NHTBbotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNkG3PVEh|ryP MX\TRW5ITVJ?
LC-1F NUC0fZdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPOcmNKSzVyPUCuOlI2QTJizszN NWPGT2xEW0GQR1XS
MHH-NB-11 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNkO4NFEh|ryP NYXqfJYxW0GQR1XS
SK-N-FI NWrESIhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HMPWlEPTB;MD62N|kyKM7:TR?= M3f0c3NCVkeHUh?=
NCI-H69 M3nZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwNkS4O|kh|ryP NWTWfI1XW0GQR1XS
SCH NXHTbXpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjFNVVKSzVyPUCuOlYxOjNizszN MUHTRW5ITVJ?
LS-513 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETkXZNKSzVyPUCuOlczPTlizszN MWPTRW5ITVJ?
CP67-MEL Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNke1PVYh|ryP MX7TRW5ITVJ?
GCIY NFHXSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwN{CzOlMh|ryP M3vwTnNCVkeHUh?=
SHP-77 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXES|JKSzVyPUCuO|A4OzRizszN NILMSJFUSU6JRWK=
EHEB NGDnVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwN{G4OVQh|ryP NIXIV3hUSU6JRWK=
D-247MG NW\IfYpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\JR2lEPTB;MD63N|I{OiEQvF2= M{LvfnNCVkeHUh?=
Raji M1XNUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwN{S5PFkh|ryP MnLYV2FPT0WU
MPP-89 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwN{W5O|gh|ryP NVnyUIpVW0GQR1XS
EKVX MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7F[opKSzVyPUCuO|kxPzNizszN M1m2NnNCVkeHUh?=
HCC2218 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjFTWM2OD1yLke5NVMyKM7:TR?= NUXmfY5vW0GQR1XS
KNS-81-FD NXPnVJdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfuVnlKSzVyPUCuPFExOTFizszN MWnTRW5ITVJ?
HCC2157 NE\rUmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\HSHAxUUN3ME2wMlg1QTVzIN88US=> MYLTRW5ITVJ?
BT-474 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLCTWM2OD1yLki4PFU1KM7:TR?= MWXTRW5ITVJ?
NCI-H748 M4TzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwOUGyJO69VQ>? NYW2NJo6W0GQR1XS
EW-24 NFnteYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWflfWhFUUN3ME2wMlkzODB{IN88US=> NV7PXmJkW0GQR1XS
D-263MG MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPsTWM2OD1yLkm0OVEzKM7:TR?= M{j1UXNCVkeHUh?=
OMC-1 NVjTWpFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHo[4lFUUN3ME2wMlk3Ozd|IN88US=> Mlr4V2FPT0WU
NCI-H2196 NF61foVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLaTWM2OD1yLkm3O|c4KM7:TR?= M{HGdXNCVkeHUh?=
HAL-01 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwOUm4O|Ih|ryP MWrTRW5ITVJ?
NCI-H2107 NHTqU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PseWlEPTB;MT6wNVg2PCEQvF2= NELxVnpUSU6JRWK=
LB996-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonVTWM2OD1zLkC4NFUyKM7:TR?= MWHTRW5ITVJ?
NCI-H1395 M3TQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLu[XJEUUN3ME2xMlExPjdizszN MVfTRW5ITVJ?
CHP-126 NFvt[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;xTWM2OD1zLkG2NVk6KM7:TR?= MYTTRW5ITVJ?
NB69 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwMk[xOFgh|ryP NWjObmE{W0GQR1XS
CAS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwM{SyN|Eh|ryP MkD4V2FPT0WU
JVM-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\qTWM2OD1zLkS3PFU2KM7:TR?= MkTFV2FPT0WU
DMS-153 NGfq[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFwNUe2O|Qh|ryP NV3pRWhmW0GQR1XS
SK-MEL-2 M1uxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn2OmlKSzVyPUGuO|E4QDlizszN NYLNNHNHW0GQR1XS
NCI-H1155 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwN{O2O|Yh|ryP M4i1b3NCVkeHUh?=
NCI-H1092 NFu5WGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTOTWM2OD1zLke2NVgzKM7:TR?= M1T1S3NCVkeHUh?=
LU-165 NFTpUJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;uTWM2OD1zLki2OFc3KM7:TR?= MnrhV2FPT0WU
HL-60 NIO0TZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTVZmdKSzVyPUGuPVk6ODhizszN Mn\lV2FPT0WU
REH MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7UR4xKSzVyPUKuNFA2QDJizszN NXvTeFc3W0GQR1XS
JVM-2 M1X5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sW5hOUUN3ME2yMlA3OTN3IN88US=> NHu4WoFUSU6JRWK=
MN-60 NY\pUXRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XoWmlEPTB;Mj6xO|MxQCEQvF2= NGTrWZVUSU6JRWK=
SCC-15 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXaTWM2OD1{LkKwNlch|ryP NYjSTFlUW0GQR1XS
SNU-C1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwMkGzOFMh|ryP MY\TRW5ITVJ?
SK-MEL-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnlTWM2OD1{LkOyNFQ4KM7:TR?= NFG3TGVUSU6JRWK=
TGW M{PVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlWzTWM2OD1{LkO1NFI4KM7:TR?= NGn2No9USU6JRWK=
CA46 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwN{W5Olch|ryP NUL6U3ZbW0GQR1XS
NCI-H23 M3H1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPvTWM2OD1{LkiwO|kyKM7:TR?= NHHVWWtUSU6JRWK=
MMAC-SF M2XWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjQNFJ6UUN3ME2yMlg3PjJ6IN88US=> MnPZV2FPT0WU
NCI-H2171 NWPTeWdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfLcVhKSzVyPUOuNFM1PDhizszN NHrvTnFUSU6JRWK=
A704 MnS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPBdY5KUUN3ME2zMlE1OTl2IN88US=> NXuxe2FXW0GQR1XS
DB NFvnTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrDTZdiUUN3ME2zMlI2PTd4IN88US=> MormV2FPT0WU
NCI-H719 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPPTWM2OD1|LkOwN|g1KM7:TR?= MkfnV2FPT0WU
MC-CAR MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\HXoU1UUN3ME2zMlU1QDF5IN88US=> NH;GZoJUSU6JRWK=
SIMA MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwNUi0NVYh|ryP NF34NWtUSU6JRWK=
SW872 M1Gxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;VfmlEPTB;Mz63PFExOSEQvF2= MnfnV2FPT0WU
HCC1187 NGPHcWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTNwN{izNVUh|ryP NFTzfZBUSU6JRWK=
EW-13 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLnVYd1UUN3ME2zMlg{PDF5IN88US=> M3PKbnNCVkeHUh?=
NCI-SNU-1 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C1bWlEPTB;ND6yNVk6QSEQvF2= NX7SRnM{W0GQR1XS
NCI-H226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HXTmlEPTB;ND6zN|YxPiEQvF2= MUXTRW5ITVJ?
RPMI-8866 NX32e4tbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M164d2lEPTB;ND6zOlAzQSEQvF2= M4jaenNCVkeHUh?=
OCI-AML2 M3GwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3mTWM2OD12LkW1NlMh|ryP M3jiSHNCVkeHUh?=
LU-65 NGfoWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3joXmlEPTB;ND65N|A{OyEQvF2= MlzxV2FPT0WU
SK-N-DZ MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLBTWM2OD13Lk[zOFY2KM7:TR?= NHnVO3ZUSU6JRWK=
NB14 NVfkOoljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnETWM2OD13Lkm3NVM2KM7:TR?= MXLTRW5ITVJ?
COLO-829 NITi[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jUZ2lEPTB;Nj6zN|M2QSEQvF2= NFvmO|BUSU6JRWK=
MHH-CALL-2 NG\6[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTlOZJ[UUN3ME22MlUyPTB6IN88US=> MlX6V2FPT0WU
NCI-H1770 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTZwNk[5NFQh|ryP NFflXIFUSU6JRWK=
ECC4 NWKzPHBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjRU3JKSzVyPU[uPFIyPzlizszN NXToWGVtW0GQR1XS
A498 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L5R2lEPTB;Nj64O|E6OiEQvF2= MYPTRW5ITVJ?
DMS-79 NX\QVpJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy0OGluUUN3ME23MlA1PTF{IN88US=> MUDTRW5ITVJ?
P30-OHK NFO2[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTdwMkG5NFYh|ryP NHraZ3pUSU6JRWK=
D-502MG M3TLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnnTlNzUUN3ME23Mlk5OzZizszN NWDRdphHW0GQR1XS
RCC10RGB M1zVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRThwME[yPEDPxE1? NWX3Z2hUW0GQR1XS
U-698-M NH61bYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRThwMkmyNlYh|ryP MX3TRW5ITVJ?
BB49-HNC MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LwT2lEPTB;OT60NlI3PSEQvF2= NEjtc5dUSU6JRWK=
ES1 NYPwV3hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHDTWM2OD17Lk[4PVU3KM7:TR?= MU\TRW5ITVJ?
MFM-223 NVfle|BRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ToVWlEPTB;MUCuPVkzPyEQvF2= NFT3R5ZUSU6JRWK=
C2BBe1 M1f3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXMfpFKSzVyPUGxMlM2OjNizszN MYjTRW5ITVJ?
EB2 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF{Lk[4PFEh|ryP M{i1dnNCVkeHUh?=
C8166 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTtS5dKSzVyPUGzMlg{ODNizszN MXTTRW5ITVJ?
ES3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TuUWlEPTB;MUOuPVk4PyEQvF2= MWLTRW5ITVJ?
NCI-H1650 M1zFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7VUJozUUN3ME2xOk4{PzZ3IN88US=> NUSzOmROW0GQR1XS
Mo-T Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLQTWM2OD1zNz60NFI6KM7:TR?= MYHTRW5ITVJ?
NB7 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF5Lke0Olch|ryP M3HW[HNCVkeHUh?=
ES7 MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF7LkW1NFch|ryP NVrY[JBvW0GQR1XS
ES5 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LRTmlEPTB;MkGuO|Y4OSEQvF2= M2\menNCVkeHUh?=
MSTO-211H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJzLki4OVgh|ryP MWDTRW5ITVJ?
U-87-MG NH\ORZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ3LkG5OlYh|ryP NH\TdohUSU6JRWK=
THP-1 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ7LkeyNFEh|ryP NX7NVJhiW0GQR1XS
NB10 NYDZO5pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzuZ|BKSzVyPUOwMlI3QTRizszN M120fXNCVkeHUh?=
NH-12 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN|LkKwNVch|ryP NXvlVmN4W0GQR1XS
COLO-824 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PEdmlEPTB;M{SuNVAxPiEQvF2= M{LNc3NCVkeHUh?=
SKM-1 M4DofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjWXZdKSzVyPUO3Mlg1OjJizszN M1mwOHNCVkeHUh?=
NCI-H1838 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\tZ3JWUUN3ME2zPE4{Pzl5IN88US=> Mn;KV2FPT0WU
RL Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN7LkK0O|ch|ryP MoTuV2FPT0WU
COLO-800 M{f4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTRyLkC3O|Mh|ryP MXjTRW5ITVJ?
KG-1 NVLCSot{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHWWWxjUUN3ME20NE45QTV3IN88US=> NVTUNnhWW0GQR1XS
TUR NFLXWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFezXnFKSzVyPUSxMlY{QTlizszN NVP1OG5[W0GQR1XS
LNCaP-Clone-FGC M{HLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTRzLkmwNVch|ryP M37DbXNCVkeHUh?=
NCI-H322M NWPNN|EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LFTGlEPTB;NEKuOVk5PCEQvF2= MUHTRW5ITVJ?
LNCaP  NWewUHN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTW4lKSzVyPUmxMlMhdk1? Mk\vNlU2ODVzN{S=
C4-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn3TWM2OD16IH7N MoLzNlU2ODVzN{S=
JURKAT M3:3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3vfnUzPCCq MUjJR|UxRTRzNj62OkBvVQ>? M4\kdFI1PTF7OUm1
MOLT-4 NFvnWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\pWVI1KGh? Mke3TWM2OD1{OEWzMlUhdk1? MlLLNlQ2OTl7OUW=
REH MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnQbYszPCCq NEjJV5FKSzVyPUK4O{43QCCwTR?= NFH1bnczPDVzOUm5OS=>
NALM-6 NU\NWJQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXSyOEBp NHfvSolKSzVyPUO0N|MxKG6P NWXrem5[OjR3MUm5PVU>
RS 4;11 NWnDUmNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfQWWszPCCq Ml3nTWM2OD13MUmuNFUhdk1? NX7scncxOjR3MUm5PVU>
697 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH22RmczPCCq MXrJR|UxRTJzMEeuNUBvVQ>? MYqyOFUyQTl7NR?=
SIL-ALL Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK5NY11OjRiaB?= M1nQUGlEPTB;MUm5Mlc4KG6P MkfLNlQ2OTl7OUW=
CEM M4TYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NISzboQzPCCq MXHJR|UxRTV{LkG4JI5O NH7rN2czPDVzOUm5OS=>
P12 NGL1U5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXaNlQhcA>? NUWwfIxYUUN3ME2zPU4zPyCwTR?= M{HsNFI1PTF7OUm1
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ACHN NITEfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j3flUuQDBibl2= MkTEPVYhcA>? MoXXTGNt MkLld5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P NEm2[HAzOTZ2MkO3OC=>
Caki-1 NVu0NHhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi1MVgxKG6P MVm5OkBp M1y5b2hEdA>? NF[2Z5h{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= NGn0S3gzOTZ2MkO3OC=>
SN12C NVnKe4FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[2XY42NThyIH7N M1rGR|k3KGh? NGjRSZVJS2x? MV7zeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? Mmf1NlE3PDJ|N{S=
HMC-1.1 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W1NVEuOTByMDDuUS=> NH72bG04OiCq MWnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MkjxNlEzPDJzOEm=
HMC-1.2 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHSb3MyNTFyMECgcm0> NYXTdXFTPzJiaB?= NWHxeFJ2cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NX3VXJpDOjF{NEKxPFk>
C2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGxMVExODBibl2= NI[yd2Q4OiCq MnvHbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m MmTmNlEzPDJzOEm=
CHP-212 NFLvUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLwXYR[OS1zMkWgcm0> MWSyOE0yOjBiaB?= NUnZPYdqcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MU[yNVE3QTJ2Mh?=
IMR-32 M4\zWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\LUVUyNTF{NTDuUS=> NH[2dpkzPC1zMkCgbC=> MoLmbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NGfh[nYzOTF4OUK0Ni=>
Kelly MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfsbIwyNTF{NTDuUS=> M3O1e|I1NTF{MDDo M1jKW4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MUOyNVE3QTJ2Mh?=
SH-EP MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OzSlEuOTJ3IH7N NV3VXHhJOjRvMUKwJIg> NHrlOI9qdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MWSyNVE3QTJ2Mh?=
SH-SY5Y NVLmXWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxMVEzPSCwTR?= M3\P[FI1NTF{MDDo MnrybY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NHr1U2czOTF4OUK0Ni=>
SK-N-AS NYS4SZJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxMVEzPSCwTR?= M1XMR|I1NTF{MDDo M2n2NYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MXqyNVE3QTJ2Mh?=
SK-N-BE NHPTcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVGxMVEzPSCwTR?= MXeyOE0yOjBiaB?= MY\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M1\RfVIyOTZ7MkSy
KG1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\0NU8yOC9zMECgcm0> MWq3NkBp MVzEUXNQ M1jwTolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NEfmepcyQTR3OEO1PC=>
U937 NFL0emNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjxeYtNOS9zMD:xNFAhdk1? M1TJblczKGh? M3HqeWROW09? NGPvVWFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NFq3V3YyQTR3OEO1PC=>
CAL62 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\TPFAvOS1zMECgcm0> M1;LeFczKGh? NHHud2hFVVOR MkXUSWM2OD1zLkSgcm0> NITDRoQyQTJ{M{W1Ny=>
OCUT-1 M3;vWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv3dJhiOC5zLUGwNEBvVQ>? M4TkXVczKGh? NH:zSVVFVVOR MYTFR|UxRTJwMzDuUS=> NXHtTFdCOTl{MkO1OVM>
8505C NHmy[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOwNE4yNTFyMDDuUS=> M{\DelczKGh? MmfMSG1UVw>? MoHhSWM2OD1|LkKgcm0> Ml7lNVkzOjN3NUO=
ACT-1 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7sNE4yNTFyMDDuUS=> MX23NkBp M{OyOGROW09? NUXuVXBJTUN3ME21MlQhdk1? M2fmW|E6OjJ|NUWz
SW1736 NUfCXmdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HMVFAvOS1zMECgcm0> NWjI[3BNPzJiaB?= MX;EUXNQ MX7FR|UxRTVwNjDuUS=> MlS4NVkzOjN3NUO=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo

BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:

[1]

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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:

[1]

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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method:

    Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A
Smiles CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID