BI 2536

Name: BI 2536
Brand: Selleck Chemicals
SKU: S1109
Rating: 5 (239 reviews)

For research use only.

Catalog No.S1109

239 publications

CAS No. 755038-02-9

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

Selleck's BI 2536 has been cited by 239 publications

Cancer Cell, 2020, 37(3):340-353

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Science, 2019, 364(6447)

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Cancer Cell, 2019, 36(2):179-193

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Cell, 2019, 36(2):179-193

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Nature, 2017, 548(7668):466-470

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Science, 2015, 13;347(6227):aaa2630.

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Cancer Discov, 2014, 4(11):1281-9

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Cell, 2011, 11;147(4):853-67.

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Cancer Cell, 2010, 18(6):641-54

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Cancer Res, 2021, canres.2276.2020

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Cell Rep, 2021, 34(9):108805

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Cancers (Basel), 2021, 13(6)1205

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J Cell Sci, 2021, 134(1)jcs251025

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Breast Cancer, 2021, 10.1007/s12282-021-01242-z

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Elife, 2021, 10e62640

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Commun Biol, 2021, 4(1):358

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STAR Protoc, 2021, 2(1):100293

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EMBO Rep, 2021, e51030

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Biomedicines, 2021, 9(5)579

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Mol Cell, 2020, S1097-2765(20)30774-7

PubMed: 33248027 ( click the link to review the publication )

Mol Cell, 2020, 10.1016/j.molcel.2020.01.023

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Nat Commun, 2020, 29;11(1):2086

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Nat Commun, 2020, 14;11(1):1819

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Autophagy, 2020, 1-17

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J Cell Biol, 2020, 219(11)e201910148

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J Cell Biol, 2020, 1;219(6):e201910019

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Cell Rep, 2020, 32(9):108080

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Cell Rep, 2020, 17;30(11):3605-3615.e5

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Cell Death Differ, 2020, 19

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Oncogene, 2020, 39(15):3145-3162

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Cancers (Basel), 2020, 12(9)E2498

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Cells, 2020, 9(9)E2126

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Cell Chem Biol, 2020, 27(3):350-362

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Curr Biol, 2020, 30(22):4519-4527.e3

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ACS Chem Biol, 2020, 20;15(3):669-674

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J Cell Sci, 2020, 2;jcs.244442

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Biochem Biophys Res Commun, 2020, 521(4):833-839

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DNA Cell Biol, 2020, 10.1089/dna.2019.5002

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Antivir Ther, 2020, 25(3):151-162

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Front Vet Sci, 2020, 7:611270

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Cell Death Differ, 2020, 10.1038

PubMed: 32015503 ( click the link to review the publication )

Sci Rep, 2020, 10(1):12327

PubMed: 32704044 ( click the link to review the publication )

Cells, 2020, 9(1)

PubMed: 31947732 ( click the link to review the publication )

J Cancer, 2020, 11(11):3274-3287

PubMed: 32231733 ( click the link to review the publication )

Neuroreport, 2020, 31(11):787-797

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Cancers (Basel), 2020, 12(7):1824

PubMed: 32645997 ( click the link to review the publication )

Cell Res, 2019, 29(7):562-578

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Mol Cell, 2019, 73(5):915-929

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Nat Commun, 2019, 10(1):3779

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Nat Commun, 2019, 10(1):1473

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Nat Commun, 2019, 10(1):993

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Sci Adv, 2019, 5(8):eaav0318

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Cell Syst, 2019, 8(2):163-167

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Cell Syst, 2019, 9(1):74-92.e8

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J Cell Biol, 2019, 218(4):1250-1264

PubMed: 30728176 ( click the link to review the publication )

EBioMedicine, 2019, 41:244-255

PubMed: 30876762 ( click the link to review the publication )

Cell Death Dis, 2019, 10(6):385

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Ther Adv Med Oncol, 2019, 11:1758835919846375

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J Mol Cell Biol, 2019, 10.1093/jmcb/mjz051

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Curr Biol, 2019, 29(7):1232-1242.e5

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Mol Cancer Ther, 2019, 18(9):1615-1627

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FEBS J, 2019, 286(5):963-974

PubMed: 30600590 ( click the link to review the publication )

Mol Cancer Res, 2019, doi: 10

PubMed: 31604847 ( click the link to review the publication )

Mol Biol Cell, 2019, 30(13):1598-1609

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Lab Invest, 2019, 99(9):1275-1286

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Sci Rep, 2019,

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Cell Div, 2019, 14:4

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J Biol Chem, 2019, 294(22):8760-8772

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Front Genet, 2019, 10:411

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Open Biol, 2019, 9(8):190136

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Mol Reprod Dev, 2019, 86(8):972-983

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Planta Med, 2019, 85(3):217-224

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Elife, 2019, 8e47097

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Mol Cell, 2018, 71(1):117-128

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EMBO Mol Med, 2018, 10(9)

PubMed: 30108112 ( click the link to review the publication )

Theranostics, 2018, 8(10):2884-2895

PubMed: 29774081 ( click the link to review the publication )

Cancer Res, 2018, 78(2):572-583

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Cell Rep, 2018, 25(13):3618-3630.e6

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Elife, 2018, 7:e36739

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Sci Signal, 2018, 11(549)

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Sci Signal, 2018, 11(530)

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Pigment Cell Melanoma Res, 2018, 31(2):253-266

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Mol Cancer Ther, 2018, 17(12):2551-2563

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Mol Cancer Ther, 2018, 17(7):1554-1565

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Mol Cell Proteomics, 2018, 17(12):2434-2447

PubMed: 30217950 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(11):5300-5310

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Hum Gene Ther, 2018, 29(8):886-901

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Sci Rep, 2018, 8(1):3521

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Cell Signal, 2018, 52:137-146

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Cancer Med, 2018, 7(11):5589-5603

PubMed: 30221846 ( click the link to review the publication )

Transl Oncol, 2018, 11(4):852-863

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PLoS One, 2018, 13(5):e0197165

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Onco Targets Ther, 2018, 11:5703-5713

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J Oncol, 2018, 2018:3979527

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Nucleic Acids Res, 2018, 46(20):10724-10739

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Br J Cancer, 2018, 118(6):e13

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Life Sci Alliance, 2018, 1(6):e201800223

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Cell Res, 2017, 27(2):274-293

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Mol Cell, 2017, 67(4):579-593

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Mol Cell, 2017, 68(1):210-223e6

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Nat Commun, 2017, 8(1):1506

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Nat Commun, 2017, 8:15289

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Dev Cell, 2017, 43(2):141-156.e7

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J Cell Biol, 2017, 216(11):3571-3590

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Cancer Res, 2017, 77(5):1142-1154

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Aging Cell, 2017, 16(3):575-584

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Elife, 2017, 6e22513

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Elife, 2017, 6

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Elife, 2017, 6e30523

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FASEB J, 2017, 32(2):625-638

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Cell Chem Biol, 2017, 24(8):1017-1028

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Cell Physiol Biochem, 2017, 43(2):431-444

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Curr Biol, 2017, 27(10):1477-1484

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Mol Cancer Ther, 2017, 16(1):3-15

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FEBS J, 2017, 284(23):4035-4050

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J Cell Physiol, 2017, 232(10):2818-2828

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Sci Rep, 2017,

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Sci Rep, 2017, 7(1):8629

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J Biol Chem, 2017, 292(36):15028-15038

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Cell Signal, 2017, 39:74-83

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Am J Physiol Cell Physiol, 2017, 313(5):C501-C515

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Cell Biosci, 2017, 7:15

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PLoS One, 2017, 12(1):e0170650

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Biochem Biophys Res Commun, 2017, 484(4):864-870

PubMed: 28188792 ( click the link to review the publication )

Oncotarget, 2017, 9(13):10920-10933

PubMed: 29541386 ( click the link to review the publication )

Oncotarget, 2017, 8(23):37633-37645

PubMed: 28430578 ( click the link to review the publication )

Nat Chem Biol, 2016, 10.1038/nchembio.2017

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Nat Commun, 2016, 7:11363

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Nat Commun, 2016, 7:10818

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Nat Chem Biol, 2016, 12(6):411-8

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Dev Cell, 2016, 37(2):174-189

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J Cell Biol, 2016, 212(7):829-43

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Cell Rep, 2016, 15(3):510-518

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Elife, 2016, 5:e11402

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Elife, 2016, 5e10734

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PLoS Pathog, 2016, 12(8):e1005860

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Mol Cancer Ther, 2016, 15(1):48-59

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J Virol, 2016, 90(6):2794-805

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Sci Rep, 2016, 6:19567

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J Biol Chem, 2016, 10.1074/jbc.M116.722751

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J Biol Chem, 2016, 10.1074/jbc.M115.712745

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J Biol Chem, 2016, 291(20):10904-15

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Cell Cycle, 2016, 15(15):2009-18

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Cell Cycle, 2016, 15(16):2216-2225

PubMed: 27248858 ( click the link to review the publication )
Cell Cycle, 2016, 15(20):2753-65

PubMed: 27579997 ( click the link to review the publication )

PLoS One, 2016, 11(4):e0153818

PubMed: 27097159 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26580-92

PubMed: 27058891 ( click the link to review the publication )

Oncotarget, 2016, 7(12):15215-29

PubMed: 26934655 ( click the link to review the publication )

Head Neck, 2016, 10.1002/hed.24349

PubMed: 26713885 ( click the link to review the publication )

Oncotarget, 2016, 7(31):50215-50228

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Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(2):113-22

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Nat Cell Biol, 2015, 17(1):31-43

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Nat Cell Biol, 2015, 17(8):1024-35

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Nat Commun, 2015, 6:8388

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Nat Commun, 2015, 10.1038/ncomms8217

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Nat Commun, 2015, 6:6891

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Nat Commun, 2015, 6:8077

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Nat Commun, 2015, 6:6946

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Nat Commun, 2015, 6:10076

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Nat Commun, 2015, 6:10072

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Genes Dev, 2015, 29(18):1969-79

PubMed: 26385965 ( click the link to review the publication )

Cancer Res, 2015, 75(2):405-14

PubMed: 25480943 ( click the link to review the publication )

J Cell Biol, 2015, 210(1):45-62

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J Control Release, 2015, 204:20-9

PubMed: 25681050 ( click the link to review the publication )

J Control Release, 2015, 204:20-29

PubMed: ( click the link to review the publication )

Cancer Lett, 2015, 357(2):591-601

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Mol Oncol, 2015, 9(2):527-43

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Mol Cell Proteomics, 2015, 14(4):946-60

PubMed: 25659891 ( click the link to review the publication )

J Neurochem, 2015, 10.1111/jnc.13085

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Mol Biol Cell, 2015, 26(3):440-52

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J Biol Chem, 2015, 290(5):3033-44

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J Biol Chem, 2015, 290(49):29617-28

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Mol Biol Cell, 2015, 26(3):440-52

PubMed: ( click the link to review the publication )

Cell Cycle, 2015, 14(2):219-31

PubMed: 25607646 ( click the link to review the publication )

Cell Cycle, 2015, 14(7):1070-81

PubMed: 25602147 ( click the link to review the publication )

Oncotarget, 2015, 6(4):2315-30

PubMed: 25537513 ( click the link to review the publication )

Oncotarget, 2015, 6(7):5275-91

PubMed: 25779659 ( click the link to review the publication )

Oncotarget, 2015, 6(11):9327-40

PubMed: 25871386 ( click the link to review the publication )

Oncotarget, 2015, 6(33):34475-93

PubMed: 26439686 ( click the link to review the publication )

Oncotarget, 2015, 6(4):2315-30

PubMed: 25537513 ( click the link to review the publication )

Nat Cell Biol, 2014, 16(6):538-49

PubMed: 24776885 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(12):3211-21

PubMed: 24771642 ( click the link to review the publication )

Cancer Res, 2014, 74(20):5878-90

PubMed: 25125659 ( click the link to review the publication )

ACS Chem Biol, 2014, 9(5):1160-71

PubMed: 24568369 ( click the link to review the publication )

Antimicrob Agents Chemother, 2014, 13(5):1054-66

PubMed: 24748653 ( click the link to review the publication )

J Biol Chem, 2014, 289(38):26344-56

PubMed: 25100726 ( click the link to review the publication )

J Biol Chem, 2014, 289(18):12313-29

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J Biol Chem, 2014, 289,14066-14074

PubMed: ( click the link to review the publication )

J Biol Chem, 2014, 289(20):14066-74

PubMed: 24706748 ( click the link to review the publication )

Cell Cycle, 2014, 13(23):3685-97

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Cell Cycle, 2014, 13(2):303-14

PubMed: 24247149 ( click the link to review the publication )
Cell Cycle, 2014, 13(24):3867-77

PubMed: 25558830 ( click the link to review the publication )

Cell Cycle, 2014, 13(14):2248-61

PubMed: 24875404 ( click the link to review the publication )

Biosci Rep, 2014, 34(3)

PubMed: 24844881 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )

PLoS One, 2014, 9(12):e115228

PubMed: 25542032 ( click the link to review the publication )

PLoS One, 2014, 8(10):e77053

PubMed: 24204733 ( click the link to review the publication )

Oncotarget, 2014, 5(12):4370-83

PubMed: 24970797 ( click the link to review the publication )

Oncotarget, 2014, 5(3):667-78

PubMed: 24525428 ( click the link to review the publication )

Oncotarget, 2014, 5(18):8379-92

PubMed: 25268741 ( click the link to review the publication )

The University of Queensland, 2014, Fawzi Faisal A. Bokhari

PubMed: ( click the link to review the publication )

Assay Drug Dev Technol, 2014, 12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Dev Cell, 2013, 25(6):555-71

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Proc Natl Acad Sci USA, 2013, 110(32):13026-31

PubMed: 23878225 ( click the link to review the publication )

Genes Dev, 2013, 27(20):2259-73

PubMed: 24142876 ( click the link to review the publication )

Cancer Res, 2013, 73(22):6722-33

PubMed: 24101154 ( click the link to review the publication )

Cancer Res, 2013, 73(2):813-23

PubMed: 23144294 ( click the link to review the publication )

Cancer Res, 2013, 73(20):6310-22

PubMed: 24067506 ( click the link to review the publication )

Cell Rep, 2013, 4(4):803-16

PubMed: 23972993 ( click the link to review the publication )

Oncogene, 2013, 10.1038/onc.2013.518

PubMed: 24317508 ( click the link to review the publication )

Br J Cancer, 2013, 110(2):510-9

PubMed: 24327015 ( click the link to review the publication )

Gynecol Oncol, 2013, 128(3):461-9

PubMed: 23146687 ( click the link to review the publication )

J Cell Sci, 2013, 126(Pt 16):3627-37

PubMed: 23750008 ( click the link to review the publication )

Mol Biol Cell, 2013, 24(24):3819-31

PubMed: 24152729 ( click the link to review the publication )

J Biol Chem, 2013, 288(33):23765-75

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J Biol Chem, 2013, 288(20):14158-69

PubMed: 23504319 ( click the link to review the publication )

Invest Ophthalmol Vis Sci, 2013, 54(13):8353-63

PubMed: 24366665 ( click the link to review the publication )

Cancer Biol Ther, 2013, 14(5):436-49

PubMed: 23377828 ( click the link to review the publication )

Cell Cycle, 2013, 12(14):2255-65

PubMed: 24067368 ( click the link to review the publication )

PLoS One, 2013, 8(10):e77390

PubMed: 24155950 ( click the link to review the publication )

J Biomol Screen, 2013, 18(1):54-66

PubMed: 22923784 ( click the link to review the publication )

Biol Open, 2013, 2(5):479-86

PubMed: 23789096 ( click the link to review the publication )

Biol Open, 2013, 2(10):1022-31

PubMed: 24167712 ( click the link to review the publication )

Cancer Res, 2013, 73(22):6667-78

PubMed: 23983103 ( click the link to review the publication )

Cell Cycle, 2013, 12(9):1340-51

PubMed: 23574746 ( click the link to review the publication )

J Biol Chem, 2012, 287(6):4376-85

PubMed: 22184120 ( click the link to review the publication )

J Biol Chem, 2012, 287(21):17088-99

PubMed: 22467873 ( click the link to review the publication )

Cell Cycle, 2012, 11(3):543-53

PubMed: 22262171 ( click the link to review the publication )

PLoS One, 2012, 7(10):e46546

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PLoS One, 2012, 7(6):e38838

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Biotechniques, 2012, 10.2144/000113866

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Biotechniques, 2012, 53(1)

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Nat Cell Biol, 2011, 13(10):1265-71

PubMed: 21874008 ( click the link to review the publication )

Cancer Res, 2011, 71(4):1385-95

PubMed: 21303981 ( click the link to review the publication )

Cancer Res, 2011, 71(17):5659-69

PubMed: 21693658 ( click the link to review the publication )

J Cell Biol, 2011, 193(6):1083-99

PubMed: 21646404 ( click the link to review the publication )

Oncogene, 2011, 30(46):4666-77

PubMed: 21602893 ( click the link to review the publication )

J Invest Dermatol, 2011, 131(9):1886-95

PubMed: 21654832 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description

Features

The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

Targets

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. ^[1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2jHNmlEPTB;MD6wNFc4PiEQvF2=	MmHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ACN	NGPiXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1rndGlEPTB;MD6wNFg1OyEQvF2=	NFHT[2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-8	NXrEOFdlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX;6d4dJUUN3ME2wMlAxQTRzIN88US=>	NIX6fHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LC-2-ad	NIjQTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml\xTWM2OD1yLkCxNFk{KM7:TR?=	NGLzVHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ALL-PO	MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnzsTWM2OD1yLkCxN{DPxE1?	NFPUdZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EW-16	MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XE[mlEPTB;MD6wNVM{PiEQvF2=	NYTlZY1TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KM12	M2rGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NV\WVZEzUUN3ME2wMlAyOzR6IN88US=>	NV;K[3NzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
GI-1	MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXnJR\|UxRTBwMEGzPFMh\|ryP	NEG3UlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-411N	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3[0OWlEPTB;MD6wNVQxPyEQvF2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES8	NYK0Z25HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYPJR\|UxRTBwMEG0PVQh\|ryP	M{e0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SNU-C2B	NELYd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlW5TWM2OD1yLkCxOVI3KM7:TR?=	MlyzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CESS	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLOTWM2OD1yLkCxOlAzKM7:TR?=	NUjCeoh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
697	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVHxNnlGUUN3ME2wMlAyPjZ6IN88US=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1963	NUXaWoJzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{exPGlEPTB;MD6wNVY4OyEQvF2=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
IA-LM	MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MY\JR\|UxRTBwMEG2PFgh\|ryP	M4PPWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SW954	NV7MbXBFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mlq3TWM2OD1yLkCxO\|A2KM7:TR?=	Mn\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RL95-2	M1H1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPwe\|BQUUN3ME2wMlAyPzN6IN88US=>	NIjENm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LXF-289	NGi4[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFfQV4pKSzVyPUCuNFE4PyEQvF2=	Mn:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
OCUB-M	NF[we29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1nl[GlEPTB;MD6wNVgzPiEQvF2=	NEn0coc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RKO	NGXVbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXj0V\|dOUUN3ME2wMlAyQTh5IN88US=>	NWrP[Wg2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LOUCY	NWroV49FT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlfMTWM2OD1yLkCyNFUh\|ryP	NHT1Z3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NOS-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoHzTWM2OD1yLkCyNFk{KM7:TR?=	M4X1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A4-Fuk	NV3vSpRIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1\kd2lEPTB;MD6wNlIyQCEQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A388	M2\1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH7wd3VKSzVyPUCuNFIzOjdizszN	MkezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
TE-9	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmG0TWM2OD1yLkCyNlYyKM7:TR?=	NEXCPIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KURAMOCHI	M2nre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX3JR\|UxRTBwMEKyPFUh\|ryP	M1HEUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KALS-1	NVzvXGZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmPKTWM2OD1yLkCyN\|M5KM7:TR?=	MoTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HOP-62	M33iWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTBwMEK0NkDPxE1?	MlPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RPMI-8402	NYTsT3RQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{\WVWlEPTB;MD6wNlUxQCEQvF2=	NEfERWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-1	M4fNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M33uXWlEPTB;MD6wNlUyOiEQvF2=	NHTaU4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CCRF-CEM	Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4HYfWlEPTB;MD6wNlU1OyEQvF2=	NVvLO2J5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HUTU-80	M{XCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1HCbGlEPTB;MD6wNlYzPCEQvF2=	NXHUWHZORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1648	M32zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{XocWlEPTB;MD6wNlY1PyEQvF2=	NWfpeoRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCE-4	M{GyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEnEfpJKSzVyPUCuNFI3QDJizszN	MnO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ETK-1	M13Hcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYW2SWpmUUN3ME2wMlAzPzN4IN88US=>	NUDDb3B4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-15	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mo\3TWM2OD1yLkCyO\|M5KM7:TR?=	M3Xm[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BE-13	NYDy[nliT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjacXNKSzVyPUCuNFI4PCEQvF2=	MmS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
KE-37	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEjCVWZKSzVyPUCuNFI4PDFizszN	NVTXNmlYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1355	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUXkO5d7UUN3ME2wMlAzPzh\|IN88US=>	NVXDOGZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-11	M4W1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXTJR\|UxRTBwMEK4NFkh\|ryP	NULRS\|d4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
BL-70	MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWHKb\|NGUUN3ME2wMlAzQDV5IN88US=>	NYnyVWpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ES6	MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1ixUWlEPTB;MD6wNlg5OSEQvF2=	M1r5VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
GT3TKB	NXPVOnBMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH[4UWlKSzVyPUCuNFI6PTNizszN	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB647-SCLC	MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUPJR\|UxRTBwMEOxPVUh\|ryP	NFXR[\|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB13	NGfYO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3HMcWlEPTB;MD6wN\|MyPiEQvF2=	NIewSmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ST486	NEW0bFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3n5eGlEPTB;MD6wN\|M{PyEQvF2=	NVnSNWZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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COLO-668	MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTBwNEW2Olgh\|ryP	M1fjdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SF539	NFXCXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4m5R2lEPTB;MD60PFY5PCEQvF2=	NWr6VpBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB2518-MEL	NHv1NHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M17qeWlEPTB;MD60PVcxOyEQvF2=	M4HqNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-441-T	Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWLJR\|UxRTBwNUCxNkDPxE1?	NF;qSpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MDA-MB-134-VI	NFLsR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVLJR\|UxRTBwNUC5NlEh\|ryP	NV7pdYZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SCC-3	Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUjJR\|UxRTBwNUG4O\|Mh\|ryP	M4rYZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KLE	M13CbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEKyXppKSzVyPUCuOVIyPzFizszN	MoGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	M2jlfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTBwNUK1NlUh\|ryP	NEK4RZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1417	Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4XlXmlEPTB;MD61N\|Q{PSEQvF2=	Mmm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2081	NEHXbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGPwR2ZKSzVyPUCuOVg3OTFizszN	NXr1e3NtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1522	NYXFTWk2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mmn0TWM2OD1yLkW5N\|g{KM7:TR?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H889	M4DrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVzuZlF7UUN3ME2wMlU6QDR2IN88US=>	NIHkclE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CGTH-W-1	NEH2SWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4r1UGlEPTB;MD62NFc2PSEQvF2=	NEXJcYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EB-3	MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTBwNkGxOVMh\|ryP	M3\GVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
D-336MG	MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlnlTWM2OD1yLk[xO\|kyKM7:TR?=	M1vIb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LC-1F	NFPqUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXnJR\|UxRTBwNkK1PVIh\|ryP	MmjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MHH-NB-11	MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF\nNlRKSzVyPUCuOlM5ODFizszN	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SK-N-FI	NY\5WWwzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlHaTWM2OD1yLk[zPVEh\|ryP	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H69	Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlzQTWM2OD1yLk[0PFc6KM7:TR?=	NHfr[2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SCH	NWLL[mszT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{\m[mlEPTB;MD62OlAzOyEQvF2=	NInHc449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-513	NF7NVHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnfjTWM2OD1yLk[3NlU6KM7:TR?=	NVPWTG42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CP67-MEL	MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NY[wXW9jUUN3ME2wMlY4PTl4IN88US=>	NXP0bld2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
GCIY	NGXsZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTBwN{CzOlMh\|ryP	M2nyblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SHP-77	NGjJWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWOwVVQ5UUN3ME2wMlcxPzN2IN88US=>	NHn1W5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EHEB	NFrzPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1LyXmlEPTB;MD63NVg2PCEQvF2=	Mn;ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
D-247MG	NV\DW485T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlvtTWM2OD1yLkezNlMzKM7:TR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
Raji	NH3jZ5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUnS[3pHUUN3ME2wMlc1QTh7IN88US=>	NVnYN3RpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MPP-89	M1vFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoPDTWM2OD1yLke1PVc5KM7:TR?=	MnvrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EKVX	M1jp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MorXTWM2OD1yLke5NFc{KM7:TR?=	NWSxTWk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCC2218	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXTJR\|UxRTBwN{mxN\|Eh\|ryP	NVXnWVBXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KNS-81-FD	NWW2XIh2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYXkPFd{UUN3ME2wMlgyODFzIN88US=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HCC2157	Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnLDTWM2OD1yLki0PVUyKM7:TR?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BT-474	M1LJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXizXW5rUUN3ME2wMlg5QDV2IN88US=>	NY[wdIJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H748	MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXzJR\|UxRTBwOUGyJO69VQ>?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EW-24	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHOwd25KSzVyPUCuPVIxODJizszN	NV3sOY84RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-263MG	NIjQRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWXnVo1IUUN3ME2wMlk1PTF{IN88US=>	NIjkNIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
OMC-1	NEi0TZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUXJ[3A6UUN3ME2wMlk3Ozd\|IN88US=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2196	NWTDfmdjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYnQSoxmUUN3ME2wMlk4Pzd5IN88US=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HAL-01	NXToc3hNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUXJR\|UxRTBwOUm4O\|Ih\|ryP	NEDhSG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2107	NH;aeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3fUNmlEPTB;MT6wNVg2PCEQvF2=	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB996-RCC	M374fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEexNI5KSzVyPUGuNFgxPTFizszN	NVvzfZBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1395	NWLrT5JVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGL6WIpKSzVyPUGuNVA3PyEQvF2=	M334U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CHP-126	Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{\nV2lEPTB;MT6xOlE6QSEQvF2=	MnH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB69	NW\qVmh{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWjJR\|UxRTFwMk[xOFgh\|ryP	NGPDO5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CAS-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUPJR\|UxRTFwM{SyN\|Eh\|ryP	NI\2NYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
JVM-3	NHrTbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnzRTWM2OD1zLkS3PFU2KM7:TR?=	NGPlW3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
DMS-153	NITHR\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXnWUYtSUUN3ME2xMlU4Pjd2IN88US=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SK-MEL-2	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWXJR\|UxRTFwN{G3PFkh\|ryP	MmLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1155	Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1zzSGlEPTB;MT63N\|Y4PiEQvF2=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1092	MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUXJR\|UxRTFwN{[xPFIh\|ryP	MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LU-165	NHnkepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTFwOE[0O\|Yh\|ryP	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HL-60	NEjyZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX\vN5FKUUN3ME2xMlk6QTB6IN88US=>	M3;qeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
REH	NYTVSlV6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlTITWM2OD1{LkCwOVgzKM7:TR?=	NVyxPWpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
JVM-2	NIrPTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWfhT3FRUUN3ME2yMlA3OTN3IN88US=>	MojHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MN-60	NX\aR5VST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUHWSHZDUUN3ME2yMlE4OzB6IN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SCC-15	NXW1WlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXvzSnpUUUN3ME2yMlIxOjdizszN	NHXITVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C1	NF:wTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vpS2lEPTB;Mj6yNVM1OyEQvF2=	M1\XS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SK-MEL-1	MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVTJR\|UxRTJwM{KwOFch\|ryP	NWjEdZNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TGW	NGHFUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3K2TGlEPTB;Mj6zOVAzPyEQvF2=	NXv3WnJRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CA46	NHXySpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTJwN{W5Olch\|ryP	NFzqVFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H23	MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXTxNpV{UUN3ME2yMlgxPzlzIN88US=>	NGX3Tms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MMAC-SF	NIPYOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWHJR\|UxRTJwOE[2Nlgh\|ryP	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2171	MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXnJR\|UxRTNwMEO0OFgh\|ryP	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A704	Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHOTWM2OD1\|LkG0NVk1KM7:TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
DB	Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIf3TnNKSzVyPUOuNlU2PzZizszN	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H719	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmHMTWM2OD1\|LkOwN\|g1KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MC-CAR	M4\zN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{i2dGlEPTB;Mz61OFgyPyEQvF2=	M2XxRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SIMA	NG\EZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUHJR\|UxRTNwNUi0NVYh\|ryP	NW\pPXBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SW872	MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXXUSJFZUUN3ME2zMlc5OTBzIN88US=>	M1\KRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC1187	NIPQTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml6zTWM2OD1\|Lke4N\|E2KM7:TR?=	MonaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EW-13	MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH20N\|VKSzVyPUOuPFM1OTdizszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-SNU-1	NF31fnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIr1cY9KSzVyPUSuNlE6QTlizszN	NX\TVVV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H226	MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVjLbWpLUUN3ME20MlM{PjB4IN88US=>	M4HCblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
RPMI-8866	M4XlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX3lfXBsUUN3ME20MlM3ODJ7IN88US=>	M4[zbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OCI-AML2	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3q4[GlEPTB;ND61OVI{KM7:TR?=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LU-65	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF3EcnFKSzVyPUSuPVMxOzNizszN	NV\P[mhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SK-N-DZ	NETqcWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDqTI1jUUN3ME21MlY{PDZ3IN88US=>	Mn[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB14	NX3jSmhJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWTIblJ5UUN3ME21Mlk4OTN3IN88US=>	M3jqd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
COLO-829	NHXBU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXy4dVJyUUN3ME22MlM{OzV7IN88US=>	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MHH-CALL-2	NHjuO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXPDTWlNUUN3ME22MlUyPTB6IN88US=>	M1nKdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H1770	NF[xd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmHITWM2OD14Lk[2PVA1KM7:TR?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ECC4	NEPC[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{W2SmlEPTB;Nj64NlE4QSEQvF2=	NETIWJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
A498	MljiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEL5ZZJKSzVyPU[uPFcyQTJizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
DMS-79	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFrjdI1KSzVyPUeuNFQ2OTJizszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
P30-OHK	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH3GcVZKSzVyPUeuNlE6ODZizszN	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
D-502MG	MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnvNTWM2OD15Lkm4N\|Yh\|ryP	MlfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RCC10RGB	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF;TdpFKSzVyPUiuNFYzQCEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
U-698-M	NIftbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFzKZmJKSzVyPUiuNlkzOjZizszN	M1LnUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BB49-HNC	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHPPU3hKSzVyPUmuOFIzPjVizszN	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES1	NFHtcJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{LUdWlEPTB;OT62PFk2PiEQvF2=	NILqcGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MFM-223	M1LhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV7JR\|UxRTFyLkm5Nlch\|ryP	M{LmSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
C2BBe1	NXXvcW9rT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MljRTWM2OD1zMT6zOVI{KM7:TR?=	M{HBclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EB2	M{O5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWXjb\|hKUUN3ME2xNk43QDhzIN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
C8166	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3TGUWlEPTB;MUOuPFMxOyEQvF2=	NH3sT\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES3	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{\PTmlEPTB;MUOuPVk4PyEQvF2=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1650	Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MknXTWM2OD1zNj6zO\|Y2KM7:TR?=	NG\QPGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
Mo-T	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmDxTWM2OD1zNz60NFI6KM7:TR?=	NVzYPYM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NB7	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEf2VmlKSzVyPUG3Mlc1PjdizszN	M3nvTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ES7	Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4\ON2lEPTB;MUmuOVUxPyEQvF2=	NHnZWpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES5	MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUTydIl{UUN3ME2yNU44PjdzIN88US=>	NFrHcow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MSTO-211H	NYfUdGNuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXzROol{UUN3ME2yNU45QDV6IN88US=>	NUDaWo5CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
U-87-MG	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4fsNWlEPTB;MkWuNVk3PiEQvF2=	NY\0XG5IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
THP-1	NFLuWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXnJR\|UxRTJ7LkeyNFEh\|ryP	NF\4XY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB10	NGizN\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4jSfGlEPTB;M{CuNlY6PCEQvF2=	NUf2fXNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NH-12	M4nm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2m2VmlEPTB;M{OuNlAyPyEQvF2=	M4X4Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
COLO-824	NUf1UIVDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4XWWmlEPTB;M{SuNVAxPiEQvF2=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SKM-1	MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEi1O2ZKSzVyPUO3Mlg1OjJizszN	Mmn4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1838	NGfwd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV;ZT3pvUUN3ME2zPE4{Pzl5IN88US=>	NX[zeHNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RL	M1rST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVL4OY5DUUN3ME2zPU4zPDd5IN88US=>	MknPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
COLO-800	NETBU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTRyLkC3O\|Mh\|ryP	M{D0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KG-1	M3z3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYPJR\|UxRTRyLki5OVUh\|ryP	M{H0[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TUR	MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFTuWJlKSzVyPUSxMlY{QTlizszN	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYHJR\|UxRTRzLkmwNVch\|ryP	Mne4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H322M	MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX3JR\|UxRTR{LkW5PFQh\|ryP	NV;KcW1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LNCaP	Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3jZZ2lEPTB;OUGuN{BvVQ>?	NUPheYh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NFUyPzRpPkK1OVA2OTd2PD;hQi=>
C4-2	NYOwVohlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{naN2lEPTB;ODDuUS=>	M3ny[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUC1NVc1Lz5{NUWwOVE4PDxxYU6=
JURKAT	MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NIPTZlgzPCCq		Mn;BTWM2OD12MU[uOlYhdk1?	M4LyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
MOLT-4	NX\DPW1tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NIO5WJQzPCCq		Mn6zTWM2OD1{OEWzMlUhdk1?	MnHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
REH	M3jW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NHvVb2UzPCCq		MXTJR\|UxRTJ6Nz62PEBvVQ>?	M3PnSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
NALM-6	NF:yRW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NW\zTWEzOjRiaB?=		MYPJR\|UxRTN2M{OwJI5O	NGrORYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
RS 4;11	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHTVflMzPCCq		NULhN2lMUUN3ME21NVkvODVibl2=	M2HpZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	NHryS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnrQNlQhcA>?		MW\JR\|UxRTJzMEeuNUBvVQ>?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NYe4dJFIOjRiaB?=		NIrHdZZKSzVyPUG5PU44PyCwTR?=	MmjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
CEM	M1zHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGnMZYgzPCCq		NIjmU2dKSzVyPUWyMlE5KG6P	Mn7NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
P12	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NE\s[oczPCCq		NV\HSZk3UUN3ME2zPU4zPyCwTR?=	NVfoSpF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-16	NWLsNpA3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnLGNlQhcA>?		MWnJR\|UxRTl4LkK4JI5O	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
JURKAT	NYXHNJhkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1u4VFQ5KGh?		NU\iU4ZyUUN3ME2xOE45PCCwTR?=	NWDhTG5iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
MOLT-4	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MX[0PEBp		NUjLV4l5UUN3ME2yOk43KG6P	M3voVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
REH	NF3sTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MWC0PEBp		MXLJR\|UxRTR2LkexJI5O	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-6	NVroeHkzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NFfpc441QCCq		NUPHT\|d5UUN3ME2yN{4zPiCwTR?=	M{X5SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MYq0PEBp		NF65c2pKSzVyPUG2OE4zQCCwTR?=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
697	NV;LbnlIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NF;TcYk1QCCq		MY\JR\|UxRTNyNT6zJI5O	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	NG\3WYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M4X6dlQ5KGh?		MY\JR\|UxRTd2Lk[yJI5O	NGPvXYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
CEM	M1rjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MW[0PEBp		NX;xSIxQUUN3ME2yOE42PSCwTR?=	Mo\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
P12	NWfaeGdCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYO0PEBp		M1f4bGlEPTB;MUiuOFYhdk1?	NYK2Z2p[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-16	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVm0PEBp		M1;ncmlEPTB;NkOuNlQhdk1?	NIjIfJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
JURKAT	NWnKe2hXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Mn;5O\|IhcA>?		NXjJOZgyUUN3ME2zMlY2KG6P	NGK0fXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
MOLT-4	NV7TfoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoPFO\|IhcA>?		NV\aWVJ7UUN3ME23MlM6KG6P	NV\1d\|Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
REH	NX\0W4NtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1XldlczKGh?		MoPqTWM2OD1zNj6wNUBvVQ>?	MnXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	NH36S5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3X1eVczKGh?		MXrJR\|UxRTFwN{igcm0>	NIjFNIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
RS 4;11	M17NW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVPvPHF2PzJiaB?=		MXPJR\|UxRTRwM{igcm0>	M4HqWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MnvWO\|IhcA>?		M4j0NWlEPTB;N{SuNlghdk1?	M1O2U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
SIL-ALL	NH25PWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1;2[FczKGh?		MX\JR\|UxRTdwMjDuUS=>	M1LHdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NEPIO5g4OiCq		NG\HdolKSzVyPUWuOFIhdk1?	MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
P12	M1vDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEjQVHk4OiCq		NVfjS5JzUUN3ME22MlM4KG6P	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NY\ueoxJPzJiaB?=		MUDJR\|UxRTd5LkezJI5O	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
Y79	MlmxRZBweHSxc3nzJGF{e2G7	NVK2elc3OS13MDDuUS=>	NXzIPIVVOTJxMkSgbC=>	MX3EUXNQ	M{fvR4lv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=>	MkPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nk[2OlUoRjJ2M{[2OlY2RC:jPh?=
WER-Rb-1	NWn6V\|BTSXCxcITvd4l{KEG\|c3H5	MYWxMVUxKG6P	MlTCNVIwOjRiaB?=	NILQenBFVVOR	NHTyRnJqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ>	NFj4RVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2OlY3PSd-MkSzOlY3PjV:L3G+
G7	NYHxXoRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnO3TWM2OD1\|LkOgcm0>	Mli2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
G166	NXnXd\|RVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGK3U4xKSzVyPUeuNEBvVQ>?	Mkn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
CB660	NGTpe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVnWOFFOUUN3ME22MlQhdk1?	NUD1[XRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNFQ4OzNpPkK0NlA1PzN\|PD;hQi=>
CB1117	M2n5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEXhSZhKSzVyPUG1MlYhdk1?	M3zWR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkC0O\|M{Lz5{NEKwOFc{OzxxYU6=
KB-3-1	MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4\6bGlEPTB;MT60PEDDuSByLkWzJI5O	M3zTNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
KB-8-5-11	M4nXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWDJR\|UxRTVwMEGgxtEhOi5yMTDuUS=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
KB-C-1	NHPUfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{eybWlEPTB;MU[uO\|YhyrFiND61NUBvVQ>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
KB-V-1	MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmnyTWM2OD1{OEGuNlQhyrFiM{GuOVchdk1?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
OVCAR-8	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3\idmlEPTB;Nz6xPUDDuSB\|Lk[wJI5O	MlHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
NCI-ADR-RES	MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlLVTWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?=	MnnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MCF7	NUW2NGN1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUnJR\|UxRTVwMUGgxtEhOS52NzDuUS=>	MnTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MCF7-FLV1000	NInMZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkP4TWM2OD1\|OUOuNVghyrFiN{SuPFMhdk1?	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
S1	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrHTWM2OD1{ND6zNEDDuSB2Lke1JI5O	M3fQdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
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CORL-23/P	NX\S[WtOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTRwM{igxtEhOS5{NTDuUS=>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
CORL-23/R	MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4[3N2lEPTB;NT6xOkDDuSBzLkizJI5O	NWe0[IRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
NIH3T3	MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Moj6TWM2OD12MD62NEDDuSB2Lkm3JI5O	NYf2[nNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
NIH3T3-G185	NHzIdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2nv[2lEPTB;MkSxN{41OCEEsTC0NlMvPjZibl2=	MkHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
pcDNA-HEK293	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUXhWWlqUUN3ME2yMlc2KMLzIECuOlchdk1?	M2\UNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
MDR19-HEK293	M3PQVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{jNOWlEPTB;OEWuOVAhyrFiMUOuOlchdk1?	MnS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
R482-HEK293	NXO3U45QT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4qxUGlEPTB;MkWuPVchyrFiND65OUBvVQ>?	NYe4co5LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MRP1-HEK293	MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfJeoc4UUN3ME2yMlk6KMLzIEGuOFkhdk1?	NGrzXIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
SF188	Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn3ENVAuOTByIH7N	M4rwZVI1NTl4IHi=	MYrEUXNQ	NHfTNWhqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK=	MlrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OEe2OFUoRjJ\|OEi3OlQ2RC:jPh?=
T98G	NIrQeJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIHmUYUyOC1zMECgcm0>	NIjYfnkzPC17NjDo	MlnsSG1UVw>?	MmDNbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6N{[0OUc,OjN6OEe2OFU9N2F-
DU145	NYrNNVBFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M{LvfWROW09?	MoDjTWM2OOLKvE[wJI5O	MmTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OES0NlgoRjJ\|OEi0OFI5RC:jPh?=
LNCaP	MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1XVbGROW09?	NGjPNI5KSzVy4pk8O\|Uhdk1?	M3zZclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEi0OFI5Lz5{M{i4OFQzQDxxYU6=
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RT4	NYTHNVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoLSTWM2OD1{Nz6yNUBvVQ>?	NULpZ4FXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVI3OzlpPkKzO\|kzPjN7PD;hQi=>
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MCF7	NH2zc4FHfW6ldHnvckBCe3OjeR?=	MlnNNVAxKG6P	Mm\pNUBp	M2\m[2ROW09?	MVjy[YR2[2W\|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC\|Mj\|CpHNmenCrbnGzMEBidmUEoGfpd5Az	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5MEK0OEc,OjN5N{CyOFQ9N2F-
KB-V1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX3JR\|UxRTNwOUKg{txO	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV7M{G5Okc,OjN3OUOxPVY9N2F-
Hec50co	NEnVNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEDJNpBKSzVyPUWgcm0>	MkToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNE[2PFcoRjJ\|MUS2Olg4RC:jPh?=
MDA-MB-468	NVnMSFM2SXCxcITvd4l{KEG\|c3H5	NVm4NZdvOS93L{GwJI5O	NFywZpkzPC92OD:3NkBp	NY\ZWlZZTE2VTx?=	NHXvVodqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	M3XJd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUS0Nlk1Lz5{M{G0OFI6PDxxYU6=
MCF10A	NE\yXpZCeG:ydH;zbZMhSXO\|YYm=	Ml74NU82NzFyIH7N	NV3ZeHlvOjRxNEivO\|IhcA>?	MXfEUXNQ	MXXpcoR2[2W\|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	Ml;CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
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MDA-MB-231	M4Ps[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;lZ4tYOC1zMECgcm0>	MVW3NkBp		NYfkVW5KcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	M1LNZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
HR5	NEHZVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIrweY0xNTFyMDDuUS=>	NULkRY9{PzJiaB?=		NUfNcmkxcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	MljYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|MEm5N\|koRjJ{M{C5PVM6RC:jPh?=
BT-474-M1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXOwMVExOCCwTR?=	NXHXeJMzPzJiaB?=		NF3yPJhqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI>	NXnYT5RbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNFk6OzlpPkKyN\|A6QTN7PD;hQi=>
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NB-EBc1	MXHxTHRUKGG\|c3H5				NIm3fIdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSi2HQnOxJINmdGy\|	Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
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A673	MnvJdWhVWyCjc4PhfS=>				MXrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDBOlc{KGOnbHzzLS=>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-37	NGTGXoJyUFSVIHHzd4F6				NInTN\|NyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1\|NzDj[Yxtew>?	NUDablkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
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Fibroblast cells	MVvxTHRUKGG\|c3H5				NWX3PZV3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG\|dDDj[Yxtew>?	M{nwRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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LAN-5	MUDxTHRUKGG\|c3H5				MkHjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEyDTj21JINmdGy\|	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	NGDKNIpyUFSVIHHzd4F6				MULxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>?	MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	NInuVolyUFSVIHHzd4F6				MnvwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR\|IHPlcIx{	NXH1TmlHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	NFXjN5VyUFSVIHHzd4F6				NGL0SGJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLV3DJINmdGy\|	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SJ-GBM2	NV\ufoNVeUiWUzDhd5NigQ>?				MorwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2ouT0KPMjDj[Yxtew>?	M{C0R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
TC32	NUTBO2xCeUiWUzDhd5NigQ>?				MXrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDUR\|MzKGOnbHzz	MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	MlnmdWhVWyCjc4PhfS=>				MWPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSbFE5KGOnbHzz	NY\PVFlURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2	MoPqdWhVWyCjc4PhfS=>				MnjjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV4Fwey1{IHPlcIx{	M{HSXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DU145	NW[5O3JtSXCxcITvd4l{KGG\|c3H5	MkfvNVAxKG6P	M{LONFI1KGi{cx?=		NEHXRWtKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIGDBVnAh[2ynYY\h[4Uh[XRiMUCwJI5OKGGodHXyJFI1KGi{czDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	NIDlSVBHfW6ldHnvckBie3OjeR?=	NIjKPWcyODBibl2=			NHz1PJNKdmirYnn0bY9vKG:oIGDMT\|EhXGi{MkGwJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDI[WxiKGOnbHzzJIF1KDFyMDDuUUBjgSCrbX31co9jdG:2dHnu[{Bu\XSqb3S=	M17mb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
DU145	NYqw[4NKTnWwY4Tpc44h[XO\|YYm=	NUjCOZZjOTByIH7N			NVH2So5KUW6qaXLpeIlwdiCxZjDQUGsyKHC{b4TlbY4h[WOldX31cIF1cW:wIHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF1KDFyMDDuUUBjgSCrbX31co9jdG:2dHnu[{Bu\XSqb3S=	MonvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
HeLa	MVnGeY5kfGmxbjDhd5NigQ>?	NVTxPFBGOTByIH7N			MYDJcohq[mm2aX;uJI9nKFCOS{GgdJJwfGWrbjDhZ4N2dXWuYYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	NXzOVnJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	NX\DNWlHTnWwY4Tpc44h[XO\|YYm=	MWqxNFAhdk1?	NXfNOWQzOThiaILz		NUSyZZpRUW6mdXP0bY9vKG:oIH3vco9xd2yjcjDtbZRwfGmlIIPwbY5ldGW\|IHnuJIh2dWGwIFjlUIEh[2WubIOgZZQhOTByIH7NJIlv[3WkYYTl[EBnd3JiMUigbJJ{KGK7IHnu[Ilz\WO2IHntcZVvd2[udX;y[ZNk\W6lZTDtbYNzd3Olb4D5	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	MX;BdI9xfG:\|aYOgZZN{[Xl?	NVzyUZpEOTByIH7N	MoLqNlQhcHK\|		M{fJc2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCSQWLQJINt\WG4YXflJIF1KDFyMDDuUUBi\nSncjCyOEBpenNiYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	Ml\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
PC3	MVzGeY5kfGmxbjDhd5NigQ>?	NXv6V2lsOTByIH7N	MmnKNVghcHK\|		NIXPfFVKdmS3Y4Tpc44hd2ZibX;uc5BwdGG{IH3peI91cWNic4DpcoRt\XNiaX6gbJVu[W5iUFOzJINmdGy\|IHH0JFExOCCwTTDpcoN2[mG2ZXSg[o9zKDF6IHjyd{BjgSCrbnTpdoVkfCCrbX31co9ndHWxcnXzZ4Vv[2VibXnjdo9{[2:yeR?=	NXnqb2RCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
DU145	MnXOSpVv[3Srb36gZZN{[Xl?	MluwNVAxKG6P			M1\BWGlvcGmkaYTpc44hd2ZiUFzLNUBVcHJ{MUCgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF1KDFyMDDuUUBjgSCrbX31co9jdG:2dHnu[{Bu\XSqb3S=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

In vivo

BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. ^[1]

Protocol

Kinase Assay: ^[1]	- Collapse Plk1 in vitro kinase assay: Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research: ^[1]	- Collapse Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc. Concentrations: Dissolved in DMSO, final concentrations ~1 μM Incubation Time: 24 and 72 hours Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: Female BomTac:NMRI-Foxn1^nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells Dosages: ~50 mg/kg Administration: Injection i.v. once or twice per week (Only for Reference)

References

Solubility (25°C)

In vitro	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	12.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI 2536 SDF

Molecular Weight	521.66
Formula	C₂₈H₃₉N₇O₃
CAS No.	755038-02-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO+ % + % Tween 80+ % ddH₂O

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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C1=C0/X	C1:	LOG(C1):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
Answer:
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

Selective Plk Inhibitors

GSK461364 : Plk1-selective, K_i=2.2 nM.
Plk Inhibitor in Clinical Trial

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
Newest Plk Inhibitor

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
Calssic Plk Inhibitor

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

Related PLK Products

Ro-3306 ^New

RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K_i of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.
ML141 ^New

ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.
HMN-214

HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
GSK461364

GSK461364 (GSK461364A) inhibits purified Plk1 with K_i of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3. Phase 1.

Features:Demonstrates >390-fold selectivity for Plk1 relative to Plk2 and Plk3.
Volasertib (BI 6727)

Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.

Features:A high volume of distribution, indicating good tissue penetration, and a long terminal half-life.
Ro3280

RO3280 (Ro5203280) is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Features:A selective PLK1 inhibitor. Demonstrates greater potency than BI2536. Potential use in nasopharyngeal carcinomas.
Onvansertib (NMS-P937)

Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.

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BI 2536