BI 2536

For research use only.

Catalog No.S1109

168 publications

BI 2536 Chemical Structure

CAS No. 755038-02-9

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

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Selleck's BI 2536 has been cited by 168 publications

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
c-Myc [3]
()
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
BRD4 [3]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 37 nM(Kd)
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NGLHZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEC3O|Yh|ryP M3X0THNCVkeHUh?=
ACN M{XUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSwTWM2OD1yLkCwPFQ{KM7:TR?= MVXTRW5ITVJ?
TE-8 NHXVPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuybFFMUUN3ME2wMlAxQTRzIN88US=> MorGV2FPT0WU
LC-2-ad NGfjSnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEGwPVMh|ryP MXPTRW5ITVJ?
ALL-PO MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfoWm9KSzVyPUCuNFE{KM7:TR?= NIHWUYxUSU6JRWK=
EW-16 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHISI1KSzVyPUCuNFE{OzZizszN NXLHSoxsW0GQR1XS
KM12 NFvv[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLEUGxiUUN3ME2wMlAyOzR6IN88US=> MkfLV2FPT0WU
GI-1 NUnlR5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K0[WlEPTB;MD6wNVM5OyEQvF2= NHzTc5hUSU6JRWK=
LS-411N M365[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEG0NFch|ryP Mn\pV2FPT0WU
ES8 NULpfJRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXibpBKSzVyPUCuNFE1QTRizszN NWXFWHVwW0GQR1XS
SNU-C2B MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPhOZVTUUN3ME2wMlAyPTJ4IN88US=> M{XDTHNCVkeHUh?=
CESS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEG2NFIh|ryP MYfTRW5ITVJ?
697 MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjWbnZKSzVyPUCuNFE3PjhizszN MojQV2FPT0WU
NCI-H1963 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7CWIFKSzVyPUCuNFE3PzNizszN M3HBbXNCVkeHUh?=
IA-LM NYfJPHlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fMeGlEPTB;MD6wNVY5QCEQvF2= NEXtSFhUSU6JRWK=
SW954 M3nZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFywbmxKSzVyPUCuNFE4ODVizszN MkDLV2FPT0WU
RL95-2 NWDXdpFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEG3N|gh|ryP NWfzOHppW0GQR1XS
LXF-289 NWrkUGk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTwUFRXUUN3ME2wMlAyPzdizszN NFXPSGZUSU6JRWK=
OCUB-M M2qxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTOTWM2OD1yLkCxPFI3KM7:TR?= M3G4T3NCVkeHUh?=
RKO Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXzTWM2OD1yLkCxPVg4KM7:TR?= MmiyV2FPT0WU
LOUCY M{DVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTkTWM2OD1yLkCyNFUh|ryP MkC2V2FPT0WU
NOS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEKwPVMh|ryP MojaV2FPT0WU
A4-Fuk NVfseW1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnnR5lKSzVyPUCuNFIzOThizszN M3rMcnNCVkeHUh?=
A388 NUTPcVZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2zPWJWUUN3ME2wMlAzOjJ5IN88US=> MX;TRW5ITVJ?
TE-9 M4ftemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEKyOlEh|ryP NFrET5dUSU6JRWK=
KURAMOCHI NV7BNIo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILqNWxKSzVyPUCuNFIzQDVizszN MkL4V2FPT0WU
KALS-1 NVOxPGZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4UWlEPTB;MD6wNlM{QCEQvF2= MmLlV2FPT0WU
HOP-62 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPjPFZKSzVyPUCuNFI1OiEQvF2= NUHke2E3W0GQR1XS
RPMI-8402 NYHHeXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfOTmlKSzVyPUCuNFI2ODhizszN MoLWV2FPT0WU
TE-1 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEK1NVIh|ryP MVrTRW5ITVJ?
CCRF-CEM M{LMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEK1OFMh|ryP M1PIeXNCVkeHUh?=
HUTU-80 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEK2NlQh|ryP NV;6WHdkW0GQR1XS
NCI-H1648 NEPuVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrLTWM2OD1yLkCyOlQ4KM7:TR?= M2LhenNCVkeHUh?=
HCE-4 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrXTWM2OD1yLkCyOlgzKM7:TR?= NYjP[nNFW0GQR1XS
ETK-1 NVvVT5o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;jNmlEPTB;MD6wNlc{PiEQvF2= MlvvV2FPT0WU
TE-15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HHcmlEPTB;MD6wNlc{QCEQvF2= MU\TRW5ITVJ?
BE-13 NGPBXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rRSGlEPTB;MD6wNlc1KM7:TR?= NEHOU45USU6JRWK=
KE-37 NXzqZYR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEK3OFEh|ryP M4jPe3NCVkeHUh?=
NCI-H1355 NY\ENWR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPDeo9KSzVyPUCuNFI4QDNizszN M1fFeHNCVkeHUh?=
TE-11 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzDdG5qUUN3ME2wMlAzQDB7IN88US=> MV7TRW5ITVJ?
BL-70 NGTBbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX4UJp4UUN3ME2wMlAzQDV5IN88US=> NHfaRYdUSU6JRWK=
ES6 M1XKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\xb|RiUUN3ME2wMlAzQDhzIN88US=> NF\ibGdUSU6JRWK=
GT3TKB NXm5O3dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHaVopKSzVyPUCuNFI6PTNizszN M17IZ3NCVkeHUh?=
LB647-SCLC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDsTWM2OD1yLkCzNVk2KM7:TR?= MUfTRW5ITVJ?
NB13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi3T2hKSzVyPUCuNFM{OTZizszN NFfj[JFUSU6JRWK=
ST486 M4fMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\5TWM2OD1yLkCzN|M4KM7:TR?= NInqVphUSU6JRWK=
NCI-H82 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzxTWM2OD1yLkCzN|Q{KM7:TR?= MVTTRW5ITVJ?
NTERA-S-cl-D1 NH;icHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u4fWlEPTB;MD6wN|M6QSEQvF2= MkW0V2FPT0WU
ES4 NU\QT5IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\IdmlEPTB;MD6wN|Q3OyEQvF2= MoPjV2FPT0WU
SK-NEP-1 M{Pv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfDfWc4UUN3ME2wMlA{PDl7IN88US=> M4HhSXNCVkeHUh?=
Becker M1;6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTsSYNKUUN3ME2wMlA{PTV3IN88US=> NUO3[pI{W0GQR1XS
A101D M3rQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPDfHZKSzVyPUCuNFM4PDhizszN NH:4PJJUSU6JRWK=
SK-UT-1 NIH1WZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfaVVNKSzVyPUCuNFM4PzRizszN NXuw[m5EW0GQR1XS
SW982 M1LCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm3c|ZDUUN3ME2wMlA{PzlizszN M2TYcnNCVkeHUh?=
TE-10 M1;R[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O0R2lEPTB;MD6wOFA1PiEQvF2= NWX1NnQ2W0GQR1XS
OVCAR-4 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTwTWM2OD1yLkC0NFU6KM7:TR?= M{nIUXNCVkeHUh?=
KP-N-YS Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn1TWM2OD1yLkC0NFg2KM7:TR?= M2TUTHNCVkeHUh?=
BL-41 NV7DR|NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDIfmRHUUN3ME2wMlA1OTJ3IN88US=> M4rWenNCVkeHUh?=
MZ1-PC NF;HZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMESxNlch|ryP MnP6V2FPT0WU
PF-382 NULjTHhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{eyb2lEPTB;MD6wOFE6QCEQvF2= M1ezR3NCVkeHUh?=
MOLT-13 NXjFcHY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrmTWM2OD1yLkC0NlM5KM7:TR?= M136N3NCVkeHUh?=
HCC1599 M1vnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm4XWVlUUN3ME2wMlA1OjV6IN88US=> NXvj[ZBLW0GQR1XS
IST-MEL1 MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7wZlJQUUN3ME2wMlA1PDR{IN88US=> MXvTRW5ITVJ?
LU-139 NF7oSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP3UXNKSzVyPUCuNFQ1PDJizszN Mm[5V2FPT0WU
MS-1 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMES3NFEh|ryP MmTNV2FPT0WU
MFH-ino NGGyTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW3TWM2OD1yLkC1NFA{KM7:TR?= NWnPNZBnW0GQR1XS
IMR-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGyNFBKSzVyPUCuNFUxOjFizszN NITFeHRUSU6JRWK=
TE-5 M{DETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjDU5FKSzVyPUCuNFUxPjNizszN MmXBV2FPT0WU
DJM-1 M1fXUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXETWM2OD1yLkC1NVQzKM7:TR?= M4C0UHNCVkeHUh?=
NB17 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDRcXZOUUN3ME2wMlA2OjB5IN88US=> NWnZPJNpW0GQR1XS
KARPAS-45 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P3RmlEPTB;MD6wOVM2QCEQvF2= NIXvbGZUSU6JRWK=
TGBC1TKB M3LRRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323PWlEPTB;MD6wOVQxPSEQvF2= NWfiSFg{W0GQR1XS
ML-2 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEW0NVQh|ryP NHvQRZZUSU6JRWK=
no-10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEW0O|Qh|ryP NFPRWHVUSU6JRWK=
CTV-1 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvzTWM2OD1yLkC1OVAzKM7:TR?= Mn61V2FPT0WU
SJSA-1 NELFdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTxbpc5UUN3ME2wMlA2PTJizszN MYfTRW5ITVJ?
HC-1 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofzTWM2OD1yLkC1OVk4KM7:TR?= MUjTRW5ITVJ?
TE-12 NWnjb2tbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PHR2lEPTB;MD6wOVYyOyEQvF2= MUXTRW5ITVJ?
KY821 NHrCe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS3Xm1qUUN3ME2wMlA2PjN{IN88US=> NG\2XmZUSU6JRWK=
TALL-1 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv3S5NuUUN3ME2wMlA2PzB6IN88US=> MXXTRW5ITVJ?
DEL MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjJTWM2OD1yLkC1O|A6KM7:TR?= MmPBV2FPT0WU
TE-6 NIjQ[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDy[pRKSzVyPUCuNFU4OjJizszN M{jrVXNCVkeHUh?=
SK-LMS-1 M2TxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\KZZV5UUN3ME2wMlA2QDB3IN88US=> MXXTRW5ITVJ?
EW-1 M1TtNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTWUlFQUUN3ME2wMlA2QDN5IN88US=> MkjnV2FPT0WU
8-MG-BA NHm4SJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTmTWM2OD1yLkC1PFUyKM7:TR?= M{DGeHNCVkeHUh?=
NALM-6 NX[4UHBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEW5O|Mh|ryP M4\xdXNCVkeHUh?=
LB771-HNC NIfGfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHtbXFKSzVyPUCuNFU6PzlizszN NVPqOZlTW0GQR1XS
HT-144 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;MdmlEPTB;MD6wOlE{KM7:TR?= M{DB[nNCVkeHUh?=
KM-H2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\t[YtKSzVyPUCuNFYzOjFizszN NEPxTFFUSU6JRWK=
SF268 M1jKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHVR2J7UUN3ME2wMlA3Ojh4IN88US=> NVvPPHNrW0GQR1XS
RS4-11 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwME[zNFQh|ryP NYTTemY4W0GQR1XS
MHH-PREB-1 NYL0VWFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fCOGlEPTB;MD6wOlMyQSEQvF2= NUL6fZVkW0GQR1XS
ATN-1 M2\mSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXtTWM2OD1yLkC2N|Q2KM7:TR?= NVLzdIJoW0GQR1XS
BB30-HNC NIHYW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwME[0N|Yh|ryP MV7TRW5ITVJ?
CPC-N MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO1XFBKSzVyPUCuNFY2OjRizszN MnLXV2FPT0WU
NB1 NELIW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXydXJTUUN3ME2wMlA3PjF|IN88US=> NVLXSG9TW0GQR1XS
KS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3RZXRKSzVyPUCuNFY4PDhizszN MUfTRW5ITVJ?
RXF393 NYnJTnVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj0PVVKSzVyPUCuNFY4PjRizszN NWLwTmRQW0GQR1XS
IST-SL2 NHvTeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL4TWM2OD1yLkC3NFA1KM7:TR?= NF3lVppUSU6JRWK=
GI-ME-N M2DKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrVSmp4UUN3ME2wMlA4Ojh4IN88US=> M{fRdnNCVkeHUh?=
VA-ES-BJ NGjBdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HFUWlEPTB;MD6wO|Q4PSEQvF2= M1LPe3NCVkeHUh?=
NCI-H1581 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELvV5RKSzVyPUCuNFc1PzhizszN NHzmdZJUSU6JRWK=
U-266 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j6UGlEPTB;MD6wO|Q6PyEQvF2= NEHwOYlUSU6JRWK=
DMS-114 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEe1Nlgh|ryP NEjBO4lUSU6JRWK=
NCI-H187 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP2dnNzUUN3ME2wMlA4PzJ4IN88US=> NVXsT5RUW0GQR1XS
SW962 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEe4N|kh|ryP MmPNV2FPT0WU
MONO-MAC-6 M{jqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fKemlEPTB;MD6wO|k5PiEQvF2= MkLJV2FPT0WU
MOLT-16 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEixNlEh|ryP M2O5dHNCVkeHUh?=
KNS-42 M4rtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTfGFjUUN3ME2wMlA5OTZzIN88US=> NVTaVY5uW0GQR1XS
CMK NYjI[4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1yLkC4NlI2KM7:TR?= MnSyV2FPT0WU
Ramos-2G6-4C10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEiyNlUh|ryP MXrTRW5ITVJ?
Daudi NFnlS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjDeFlKSzVyPUCuNFgzPTZizszN M3nqRXNCVkeHUh?=
NCI-H510A NV;YUnZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml25TWM2OD1yLkC4N|M3KM7:TR?= NI\QO5lUSU6JRWK=
LB831-BLC NHPMeodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHHTWM2OD1yLkC4OVYyKM7:TR?= NIHFUI1USU6JRWK=
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LB2518-MEL NUXLfZdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnwOWNKSzVyPUCuOFk4ODNizszN M3jBVXNCVkeHUh?=
TE-441-T M4r4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml61TWM2OD1yLkWwNVIh|ryP NFfPTnVUSU6JRWK=
MDA-MB-134-VI M1flVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTSXIxKSzVyPUCuOVA6OjFizszN NWj0[ZByW0GQR1XS
SCC-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnYTmdKSzVyPUCuOVE5PzNizszN MknoV2FPT0WU
KLE M2C4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjzb4FjUUN3ME2wMlUzOTdzIN88US=> MkTCV2FPT0WU
LB2241-RCC M2jDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjXRpExUUN3ME2wMlUzPTJ3IN88US=> M4\pdXNCVkeHUh?=
NCI-H1417 M2Xob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ERo1KSzVyPUCuOVM1OzVizszN NIrlN|hUSU6JRWK=
NCI-H2081 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O3eWlEPTB;MD61PFYyOSEQvF2= MUXTRW5ITVJ?
NCI-H1522 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TEemlEPTB;MD61PVM5OyEQvF2= MYTTRW5ITVJ?
NCI-H889 M{\UdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nrTWlEPTB;MD61PVg1PCEQvF2= M1rTcHNCVkeHUh?=
CGTH-W-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;VfmpEUUN3ME2wMlYxPzV3IN88US=> NUfrUWI4W0GQR1XS
EB-3 NUHlfopPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSyTWM2OD1yLk[xNVU{KM7:TR?= M4XWVHNCVkeHUh?=
D-336MG NEKyc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XaZ2lEPTB;MD62NVc6OSEQvF2= NXnUemd3W0GQR1XS
LC-1F NIXlOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\UNo9KSzVyPUCuOlI2QTJizszN M2fz[3NCVkeHUh?=
MHH-NB-11 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwNkO4NFEh|ryP M1\2c3NCVkeHUh?=
SK-N-FI M1PBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDITWM2OD1yLk[zPVEh|ryP MnnzV2FPT0WU
NCI-H69 NYLzTlNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPNm5uUUN3ME2wMlY1QDd7IN88US=> NXu1RnRJW0GQR1XS
SCH MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rTbGlEPTB;MD62OlAzOyEQvF2= NWHw[YJJW0GQR1XS
LS-513 M4nJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXLTWM2OD1yLk[3NlU6KM7:TR?= M3;IOHNCVkeHUh?=
CP67-MEL M{flPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHJRoFqUUN3ME2wMlY4PTl4IN88US=> NFv3dmVUSU6JRWK=
GCIY M2\IT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrhV29KSzVyPUCuO|A{PjNizszN MULTRW5ITVJ?
SHP-77 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;BOmlEPTB;MD63NFc{PCEQvF2= NX;lN4hbW0GQR1XS
EHEB MnjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF34UXNKSzVyPUCuO|E5PTRizszN M4DFWHNCVkeHUh?=
D-247MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwN{OyN|Ih|ryP NUHR[GZTW0GQR1XS
Raji NHPwVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC1TWM2OD1yLke0PVg6KM7:TR?= NGfaTWFUSU6JRWK=
MPP-89 M2XpeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInrZoJKSzVyPUCuO|U6PzhizszN NWjqRYlPW0GQR1XS
EKVX M3jiV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwN{mwO|Mh|ryP MYnTRW5ITVJ?
HCC2218 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXyxV2NrUUN3ME2wMlc6OTNzIN88US=> NFmzV4tUSU6JRWK=
KNS-81-FD NES1c3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwOEGwNVEh|ryP MmT6V2FPT0WU
HCC2157 NIXy[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwOES5OVEh|ryP NYT2fVd6W0GQR1XS
BT-474 NVz4Wmh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwOEi4OVQh|ryP MVHTRW5ITVJ?
NCI-H748 NVzoeHJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPrTWM2OD1yLkmxNkDPxE1? M2ntPXNCVkeHUh?=
EW-24 MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPYbYJKSzVyPUCuPVIxODJizszN NIS1UItUSU6JRWK=
D-263MG Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jFOmlEPTB;MD65OFUyOiEQvF2= MofzV2FPT0WU
OMC-1 M{f0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwOU[zO|Mh|ryP NGPUWnFUSU6JRWK=
NCI-H2196 NXfETXpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;t[2lEPTB;MD65O|c4PyEQvF2= NVrVXVdWW0GQR1XS
HAL-01 NH7zcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOzRmZ6UUN3ME2wMlk6QDd{IN88US=> MkfCV2FPT0WU
NCI-H2107 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXsWJZkUUN3ME2xMlAyQDV2IN88US=> Mn;vV2FPT0WU
LB996-RCC M4DEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzNdXVKSzVyPUGuNFgxPTFizszN NHn3bZVUSU6JRWK=
NCI-H1395 NVrFS5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK3TWM2OD1zLkGwOlch|ryP MWPTRW5ITVJ?
CHP-126 M{LMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHXWZdoUUN3ME2xMlE3OTl7IN88US=> M1HxenNCVkeHUh?=
NB69 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n2c2lEPTB;MT6yOlE1QCEQvF2= NVTzTIdtW0GQR1XS
CAS-1 NVfu[oF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFwM{SyN|Eh|ryP M4TrWHNCVkeHUh?=
JVM-3 Mn3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwNEe4OVUh|ryP NXjiVIl2W0GQR1XS
DMS-153 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwNUe2O|Qh|ryP MX7TRW5ITVJ?
SK-MEL-2 NFvnRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz6O2VzUUN3ME2xMlcyPzh7IN88US=> NEHaTZBUSU6JRWK=
NCI-H1155 M36xVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nQ[GlEPTB;MT63N|Y4PiEQvF2= MWTTRW5ITVJ?
NCI-H1092 MkH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnHSHRzUUN3ME2xMlc3OTh{IN88US=> M370SnNCVkeHUh?=
LU-165 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwOE[0O|Yh|ryP M4jSeXNCVkeHUh?=
HL-60 NYPjXZBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwOUm5NFgh|ryP NFTkVplUSU6JRWK=
REH M3\CRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfKUY5KSzVyPUKuNFA2QDJizszN NWLNUnBrW0GQR1XS
JVM-2 NHL4[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjHdnJlUUN3ME2yMlA3OTN3IN88US=> MXrTRW5ITVJ?
MN-60 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1{LkG3N|A5KM7:TR?= M3XFVnNCVkeHUh?=
SCC-15 NXX6XFUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJwMkCyO{DPxE1? Mn3BV2FPT0WU
SNU-C1 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwMkGzOFMh|ryP M3HS[XNCVkeHUh?=
SK-MEL-1 NV62fXR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PmTGlEPTB;Mj6zNlA1PyEQvF2= MX;TRW5ITVJ?
TGW M3H1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLkcYVKSzVyPUKuN|UxOjdizszN NW\tUXg1W0GQR1XS
CA46 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK1NFdKSzVyPUKuO|U6PjdizszN NUHTUIo1W0GQR1XS
NCI-H23 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwOEC3PVEh|ryP MWPTRW5ITVJ?
MMAC-SF M2L4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LMXWlEPTB;Mj64OlYzQCEQvF2= NETNNIFUSU6JRWK=
NCI-H2171 NWjBU2ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;0ZXpKSzVyPUOuNFM1PDhizszN M3TmRnNCVkeHUh?=
A704 NFHKeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwMUSxPVQh|ryP MVXTRW5ITVJ?
DB M{\BS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\pTWM2OD1|LkK1OVc3KM7:TR?= MUDTRW5ITVJ?
NCI-H719 NFPkUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrRU3VKSzVyPUOuN|A{QDRizszN MkPGV2FPT0WU
MC-CAR MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XwU2lEPTB;Mz61OFgyPyEQvF2= MYHTRW5ITVJ?
SIMA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33GZ2lEPTB;Mz61PFQyPiEQvF2= NWHxZ3pHW0GQR1XS
SW872 NYLpbmRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Htb2lEPTB;Mz63PFExOSEQvF2= NX31OpVnW0GQR1XS
HCC1187 M1vQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwN{izNVUh|ryP NH;MSIhUSU6JRWK=
EW-13 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDzVHpKSzVyPUOuPFM1OTdizszN NXPzV5FWW0GQR1XS
NCI-SNU-1 NX71[G41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4exZ2lEPTB;ND6yNVk6QSEQvF2= MXjTRW5ITVJ?
NCI-H226 NInzZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnqbIJKSzVyPUSuN|M3ODZizszN M33EZnNCVkeHUh?=
RPMI-8866 M13XWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHTWmJKSzVyPUSuN|YxOjlizszN MYfTRW5ITVJ?
OCI-AML2 NW\yXnRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULW[2JLUUN3ME20MlU2OjNizszN MWDTRW5ITVJ?
LU-65 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O5T2lEPTB;ND65N|A{OyEQvF2= M3fPV3NCVkeHUh?=
SK-N-DZ NH\DSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTVwNkO0OlUh|ryP MX\TRW5ITVJ?
NB14 M{\PNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf4WHlMUUN3ME21Mlk4OTN3IN88US=> NH2wPGdUSU6JRWK=
COLO-829 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf1O4VKSzVyPU[uN|M{PTlizszN NVyzTZhHW0GQR1XS
MHH-CALL-2 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fEUmlEPTB;Nj61NVUxQCEQvF2= NX7aPWhTW0GQR1XS
NCI-H1770 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTZwNk[5NFQh|ryP NW\zSZRmW0GQR1XS
ECC4 NYHNRoliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrFWXZKSzVyPU[uPFIyPzlizszN NVLpcGtiW0GQR1XS
A498 NWDSWmF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi3O|RWUUN3ME22Mlg4OTl{IN88US=> MXfTRW5ITVJ?
DMS-79 NWnxPZdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;rN2lEPTB;Nz6wOFUyOiEQvF2= NVGxZm5DW0GQR1XS
P30-OHK NH7pSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjyOYZsUUN3ME23MlIyQTB4IN88US=> M{jlTnNCVkeHUh?=
D-502MG NVHKb|M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnqRmdKSzVyPUeuPVg{PiEQvF2= MX;TRW5ITVJ?
RCC10RGB NFL3[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml60TWM2OD16LkC2Nlgh|ryP MonJV2FPT0WU
U-698-M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRThwMkmyNlYh|ryP MlLkV2FPT0WU
BB49-HNC NF;M[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTlwNEKyOlUh|ryP NHr6PJRUSU6JRWK=
ES1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDxTWM2OD17Lk[4PVU3KM7:TR?= Mmm4V2FPT0WU
MFM-223 MlHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPucYt6UUN3ME2xNE46QTJ5IN88US=> NHXU[3JUSU6JRWK=
C2BBe1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPvTWM2OD1zMT6zOVI{KM7:TR?= NI[yR2NUSU6JRWK=
EB2 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvwTWM2OD1zMj62PFgyKM7:TR?= M{HvdXNCVkeHUh?=
C8166 NUfMOII2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nVeWlEPTB;MUOuPFMxOyEQvF2= MWTTRW5ITVJ?
ES3 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX6NnlKSzVyPUGzMlk6PzdizszN NXzBfHlsW0GQR1XS
NCI-H1650 NIC0T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e0XmlEPTB;MU[uN|c3PSEQvF2= MlHuV2FPT0WU
Mo-T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPSSXpKSzVyPUG3MlQxOjlizszN NXXNNYVbW0GQR1XS
NB7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoniTWM2OD1zNz63OFY4KM7:TR?= M2DL[nNCVkeHUh?=
ES7 NVvYbHpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHtTWM2OD1zOT61OVA4KM7:TR?= M{jkXHNCVkeHUh?=
ES5 NG\nV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TRRWlEPTB;MkGuO|Y4OSEQvF2= NYPwcGNLW0GQR1XS
MSTO-211H NVHwXo46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfQTWM2OD1{MT64PFU5KM7:TR?= NIL5c|ZUSU6JRWK=
U-87-MG NWX5XWJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnhTWM2OD1{NT6xPVY3KM7:TR?= MUTTRW5ITVJ?
THP-1 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HuR2lEPTB;MkmuO|IxOSEQvF2= NG\RVphUSU6JRWK=
NB10 NYO1UphTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPETWM2OD1|MD6yOlk1KM7:TR?= M{jMfXNCVkeHUh?=
NH-12 M2nwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTwU29KSzVyPUOzMlIxOTdizszN MXHTRW5ITVJ?
COLO-824 NHTzVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnmTWM2OD1|ND6xNFA3KM7:TR?= NUHIU4h7W0GQR1XS
SKM-1 NEjSd25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDv[G5KSzVyPUO3Mlg1OjJizszN MWjTRW5ITVJ?
NCI-H1838 NXHhZ3lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\4TWM2OD1|OD6zO|k4KM7:TR?= NFzBUmNUSU6JRWK=
RL MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN7LkK0O|ch|ryP MULTRW5ITVJ?
COLO-800 MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRyLkC3O|Mh|ryP MWLTRW5ITVJ?
KG-1 NY\VbXp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTWTWM2OD12MD64PVU2KM7:TR?= Mn7RV2FPT0WU
TUR MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vxT2lEPTB;NEGuOlM6QSEQvF2= MV\TRW5ITVJ?
LNCaP-Clone-FGC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPzb|BKSzVyPUSxMlkxOTdizszN M2q1V3NCVkeHUh?=
NCI-H322M MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzoTWM2OD12Mj61PVg1KM7:TR?= NES0e25USU6JRWK=
LNCaP  M{K3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pp[WlEPTB;OUGuN{BvVQ>? MUKyOVUxPTF5NB?=
C4-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PQb2lEPTB;ODDuUS=> Mn3GNlU2ODVzN{S=
JURKAT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T0clI1KGh? MV\JR|UxRTRzNj62OkBvVQ>? NYDqUHlROjR3MUm5PVU>
MOLT-4 NVyybYhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWeyOEBp MkHYTWM2OD1{OEWzMlUhdk1? MV:yOFUyQTl7NR?=
REH MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrONGgzPCCq MWHJR|UxRTJ6Nz62PEBvVQ>? NF7UUoozPDVzOUm5OS=>
NALM-6 NVLiOnpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfLXVljOjRiaB?= NXHoPFdKUUN3ME2zOFM{OCCwTR?= M2\NR|I1PTF7OUm1
RS 4;11 NFHPO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\uUFI1KGh? M3LyXWlEPTB;NUG5MlA2KG6P NEm3V2YzPDVzOUm5OS=>
697 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfuNlQhcA>? NHK0WVZKSzVyPUKxNFcvOSCwTR?= MX6yOFUyQTl7NR?=
SIL-ALL NVv2d2tCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVexbYdHOjRiaB?= NUSx[lROUUN3ME2xPVkvPzdibl2= NIq4bWczPDVzOUm5OS=>
CEM M3Kw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3YPGczPCCq NGfOOGlKSzVyPUWyMlE5KG6P MViyOFUyQTl7NR?=
P12 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXoNlQhcA>? MmPzTWM2OD1|OT6yO{BvVQ>? M1vuWFI1PTF7OUm1
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ACHN NES5XlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\qVFUuQDBibl2= NWLCR21UQTZiaB?= NV:xZohiUEOu NGn2d2Z{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= M2nGPFIyPjR{M{e0
Caki-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[1MVgxKG6P Mn24PVYhcA>? M3T1UWhEdA>? M13lNpN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MVmyNVY1OjN5NB?=
SN12C NVqycphbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHlT2gzPS16MDDuUS=> M13QPFk3KGh? M3m1bGhEdA>? NU\0SIJKe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NYHuWoF{OjF4NEKzO|Q>
HMC-1.1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz4RYUyNTFyMECgcm0> MX63NkBp NInlbVFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? MVmyNVI1OjF6OR?=
HMC-1.2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXuxMVExODBibl2= NF31XFM4OiCq NEH3fYdqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? MnjUNlEzPDJzOEm=
C2 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0NU0yODByIH7N MnPzO|IhcA>? Mn;HbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m NGrsNlIzOTJ2MkG4PS=>
CHP-212 NHzWdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLMVYhWOS1zMkWgcm0> NF70WHczPC1zMkCgbC=> NXuzTnhJcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NWHsXppWOjFzNkmyOFI>
IMR-32 M2X0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xMVEzPSCwTR?= MnvXNlQuOTJyIHi= NGC4d5ZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M4jyWlIyOTZ7MkSy
Kelly NG\iS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCwNU0yOjVibl2= NInve2IzPC1zMkCgbC=> MYnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n M3:zXlIyOTZ7MkSy
SH-EP M1LZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP3Tm1EOS1zMkWgcm0> MUiyOE0yOjBiaB?= NF;vNWlqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MXSyNVE3QTJ2Mh?=
SH-SY5Y MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWwNU0yOjVibl2= M{DnVFI1NTF{MDDo M1zqd4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NFfwcpkzOTF4OUK0Ni=>
SK-N-AS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTWNU0yOjVibl2= M1TmUVI1NTF{MDDo NUHXTmVlcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M{jXbVIyOTZ7MkSy
SK-N-BE MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHEc|c3OS1zMkWgcm0> Mnz4NlQuOTJyIHi= NGf5bmJqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MXWyNVE3QTJ2Mh?=
KG1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3r[Yh7OS9zMD:xNFAhdk1? NEDGSW04OiCq M1Po[2ROW09? Mk\TbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= M{jVWlE6PDV6M{W4
U937 NILNOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTZRW9sOS9zMD:xNFAhdk1? MnLQO|IhcA>? M3fvN2ROW09? M{TOOIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MVyxPVQ2QDN3OB?=
CAL62 NIP2cVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z0[FAvOS1zMECgcm0> Mlv1O|IhcA>? MX;EUXNQ MV7FR|UxRTFwNDDuUS=> MYmxPVIzOzV3Mx?=
OCUT-1 NFXaTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q0W|AvOS1zMECgcm0> NYSwWHdqPzJiaB?= NGLmOpVFVVOR MoHzSWM2OD1{LkOgcm0> M4\oNFE6OjJ|NUWz
8505C NGT5eFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDYOFUxNjFvMUCwJI5O M1XGSVczKGh? NV7JWlRQTE2VTx?= NUfpZnliTUN3ME2zMlIhdk1? M2LaS|E6OjJ|NUWz
ACT-1 NGTjS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV2wMlEuOTByIH7N NVrpTYVyPzJiaB?= MWfEUXNQ MXTFR|UxRTVwNDDuUS=> M1v4PVE6OjJ|NUWz
SW1736 M4rPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j1VFAvOS1zMECgcm0> NYHlN25YPzJiaB?= MYHEUXNQ NFTPOo9GSzVyPUWuOkBvVQ>? M3KyO|E6OjJ|NUWz

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
In vivo

BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:

[1]

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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:

[1]

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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method:

    Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (40.25 mM)
Water Insoluble
Ethanol '100 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A
Smiles CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID