MAZ51

Catalog No.S0765

For research use only.

MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.

MAZ51 Chemical Structure

CAS No. 163655-37-6

Purity & Quality Control

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Biological Activity

Description MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.
Targets
VEGFR-3 [1]
()
Akt [1]
()
GSK3β [1]
()
RhoA [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 15 mg/mL
(47.71 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 314.38
Formula

C21H18N2O

CAS No. 163655-37-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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