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Ganetespib (STA-9090)

Name: Ganetespib (STA-9090)
Brand: Selleck Chemicals
SKU: S1159
Rating: 5 (45 reviews)

Catalog No.S1159

For research use only.

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

Ganetespib (STA-9090) Chemical Structure

CAS No. 888216-25-9

Selleck's Ganetespib (STA-9090) has been cited by 45 publications

Purity & Quality Control

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HSP (HSP90) Signaling Pathway Map

Biological Activity

Description

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

Targets

HSP90 ^[1]
(OSA 8 cells)

4 nM

In vitro

The 50% inhibitory concentrations (IC50) for Ganetespib against malignant mast cell lines are 10-50 times lower than that for 17-AAG, indicating that triazolone class of HSP90 inhibitors likely exhibits greater potency than geldanamycin based inhibitors. ^[1] Ganetespib inhibits MG63 cell lines with IC50 of 43 nM. ^[1] Ganetespib binds to the ATP-binding domain at the N-terminus of Hsp90 and serves as a potent Hsp90 inhibitor by causing degradation of multiple oncogenic Hsp90 client proteins including HER2/neu, mutated EGFR, Akt, c-Kit, IGF-1R, PDGFRα, Jak1, Jak2, STAT3, STAT5, HIF-1α, CDC2 and c-Met as well as Wilms' tumor 1. ^[2] Ganetespib, at low nanomolar concentrations, potently arrests cell proliferation and induces apoptosis in a wide variety of human cancer cell lines, including many receptor tyrosine kinase inhibitor- and tanespimycin-resistant cell lines. Ganetespib exhibits potent cytotoxicity in a range of solid and hematologic tumor cell lines, including those that express mutated kinases that confer resistance to small-molecule tyrosine kinase inhibitors. ^[3] Ganetespib treatment rapidly caused the degradation of known Hsp90 client proteins, exhibits superior potency to the ansamycin inhibitor 17-AAG, and shows sustained activity even with short exposure times.^[3] In anohter study, Ganetespib induces apoptosis of malignant canine mast cell lines. Ganetespib is active at significantly lower concentrations for C2 and BR canine malignant mast cells with IC50 of 19 and 4 nM, respectively, while 17-AAG inhibits C2 and BR canine malignant mast cells with IC50 of 958 and 44 nM, respectively. ^[4] Both the expression of WT and mutant Kit are downregulated by 100 nM Ganetespib after 24 hours in all lines treated including C2 and BMCMCs cells. However, no effects on PI3K or HSP90 expression are observed following treatment with Ganetespib.^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

NCI-H1975	NV73fnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWe3NkBp		MYHJR\|UxRThibl2=	NFTLXWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0OFY3PSd-MkKxOFQ3PjV:L3G+
NCI-H1975	M13uVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEToe3Q1QCCq		NX;UbWF5UUN3ME2xOkBvVQ>?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2NE[2OUc,OjJzNES2OlU9N2F-
Calu-6	NWq1VnVFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{XHXmlEPTB;NkSgcm0>	M2n6clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEGyNlQ5Lz5{M{CxNlI1QDxxYU6=
Calu-1	M12w[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTV6IH7N	NHfxO4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H2122	MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2GyXWlEPTB;NUOgcm0>	MoKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
A549	M3;hSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVjh[GJiUUN3ME20N{BvVQ>?	MkPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
H358	M1LOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWHJR\|UxRTJ7IH7N	Mkf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
H1734	M1;4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWnaWolrUUN3ME2yPEBvVQ>?	Mn[0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
H727	NGDU[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3XaeGlEPTB;Mkigcm0>	Mm\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
COR-L23	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEPVU21KSzVyPUKyJI5O	NF\xTYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H1792	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;jfVVLUUN3ME2yNEBvVQ>?	M3fGZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEGyNlQ5Lz5{M{CxNlI1QDxxYU6=
H2009	NHrqfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUnJR\|UxRTF7IH7N	NWHWZmJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVIzPDhpPkKzNFEzOjR6PD;hQi=>
SK-LU-1	M{frXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUXJR\|UxRTF6IH7N	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMkK0PEc,OjNyMUKyOFg9N2F-
H2212	M2HJfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml3KTWM2OD1zNzDuUS=>	NF;YepY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H441	NUT5[ldJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLtTWM2OD1zNDDuUS=>	NX7wcJJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVIzPDhpPkKzNFEzOjR6PD;hQi=>
H2030	NX3pTlM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVnNUo96UUN3ME2xNkBvVQ>?	NIXXeIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H23	NFz5W5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTFzIH7N	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMkK0PEc,OjNyMUKyOFg9N2F-
HOP-62	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIjve21KSzVyPUGxJI5O	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMkK0PEc,OjNyMUKyOFg9N2F-
IA-LM	M2jBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1e4[WlEPTB;MUCgcm0>	MkjjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUKyOFgoRjJ\|MEGyNlQ5RC:jPh?=
H460	NWjMO5c6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlniTWM2OD16IH7N	NFHMeos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H157	NEXuenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{f5VGlEPTB;NzDuUS=>	NIrJSJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNlI1QCd-MkOwNVIzPDh:L3G+
H1355	NFHqUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vGUWlEPTB;NTDuUS=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMkK0PEc,OjNyMUKyOFg9N2F-
VCaP	M4LQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2D6emlEPTB;NzDuUS=>	Mn:1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUKwNFQoRjJ\|MUWyNFA1RC:jPh?=
LNCaP	MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHnlNIhKSzVyPUigcm0>	NGXM[I09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1NlAxPCd-MkOxOVIxODR:L3G+
Ramos-RA1	MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlvnTWM2OD15LkSgcm0>	NFfFNW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwN\|c1OSd-MkOzNFM4PDF:L3G+
Karpas-299	NUK4Z25tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHLyfIlKSzVyPUmuOkBvVQ>?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
Kasumi-1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2L0dmlEPTB;NT64JI5O	NWjlfo1zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM4PDFpPkKzN\|A{PzRzPD;hQi=>
CCRF-CEM (2)	M3rkTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1HxTWlEPTB;Nz6yJI5O	NHHafHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwN\|c1OSd-MkOzNFM4PDF:L3G+
CCRF-CEM (1)	M1znXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2nqNWlEPTB;MUKuOUBvVQ>?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
MOLT-4	MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX[zUIN5UUN3ME2xNE43KG6P	NV;VPXlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM4PDFpPkKzN\|A{PzRzPD;hQi=>
RS4;11	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUjuWYk4UUN3ME2xN{42KG6P	NH;XbY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwN\|c1OSd-MkOzNFM4PDF:L3G+
COG-LL-317	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3L5[mlEPTB;ND60JI5O	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
NALM-6	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWHYc\|VyUUN3ME2xNU44KG6P	NULsXGIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM4PDFpPkKzN\|A{PzRzPD;hQi=>
CHLA-136	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlP4TWM2OD1{Mz6yJI5O	MmfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEO3OFEoRjJ\|M{CzO\|QyRC:jPh?=
CHLA-90	MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkDHTWM2OD1{Mj6zJI5O	Mn;1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEO3OFEoRjJ\|M{CzO\|QyRC:jPh?=
NB-EBc1	NXTVXYFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH3POWVKSzVyPUG2Mlghdk1?	NXHWbXhVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM4PDFpPkKzN\|A{PzRzPD;hQi=>
NB-1643	NY\wXHVOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1\ad2lEPTB;Nz60JI5O	M1;JWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CzO\|QyLz5{M{OwN\|c1OTxxYU6=
SJ-GBM2	M{TXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7EPXFKSzVyPUGyMlkhdk1?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
CHLA-258	NF:wO\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MU\JR\|UxRTZwNDDuUS=>	NEjZV3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwN\|c1OSd-MkOzNFM4PDF:L3G+
CHLA-10	NXvTV4lvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2r5bGlEPTB;NT63JI5O	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
CHLA-9	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2HMdmlEPTB;ND62JI5O	NUP0N49SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM4PDFpPkKzN\|A{PzRzPD;hQi=>
TC-71	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUXJR\|UxRTRwNTDuUS=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
CHLA-266	NEHjWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXXJR\|UxRTJ5LkGgcm0>	M1nz[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CzO\|QyLz5{M{OwN\|c1OTxxYU6=
BT-12	NX;nd4d7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml72TWM2OD1zND6zJI5O	MnS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEO3OFEoRjJ\|M{CzO\|QyRC:jPh?=
Rh30	NHTGZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mme1TWM2OD13Lk[gcm0>	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyM{e0NUc,OjN\|MEO3OFE9N2F-
Rh18	NYjPfFVDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MojhTWM2OD14LkKgcm0>	M3TKe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CzO\|QyLz5{M{OwN\|c1OTxxYU6=
Rh41	NI\RUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUPYZXJtUUN3ME2xNE41KG6P	Mlz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEO3OFEoRjJ\|M{CzO\|QyRC:jPh?=
RD	NHzGU\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRThibl2=	NF;LV\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwN\|c1OSd-MkOzNFM4PDF:L3G+
K033	MVvBdI9xfG:\|aYOgRZN{[Xl?	MU[xNFAhdk1?	MY[3NkBp		Mmntd4lodmmoaXPhcpRtgSCrbnT1Z4V{KGGyb4D0c5Nqew>?	MkPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUi1NlMoRjJ\|NEG4OVI{RC:jPh?=
M23	MkHyRZBweHSxc3nzJGF{e2G7	M4HxXFExOCCwTR?=	NVHNdodSPzJiaB?=		NWLlO2x{e2mpbnnmbYNidnSueTDpcoR2[2W\|IHHwc5B1d3Orcx?=	M2TGUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEG4OVI{Lz5{M{SxPFUzOzxxYU6=
K029	NFLBRnhCeG:ydH;zbZMhSXO\|YYm=	M3PGOlExOCCwTR?=	MnjKO\|IhcA>?		MUDzbYdvcW[rY3HueIx6KGmwZIXj[ZMh[XCxcITvd4l{	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOEWyN{c,OjN2MUi1NlM9N2F-
K028	M2XYTGFxd3C2b4Ppd{BCe3OjeR?=	NFXYZpoyODBibl2=	NYXF[nE4PzJiaB?=		MmTud4lodmmoaXPhcpRtgSCrbnT1Z4V{KGGyb4D0c5Nqew>?	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOEWyN{c,OjN2MUi1NlM9N2F-
K008	MUfBdI9xfG:\|aYOgRZN{[Xl?	MVqxNFAhdk1?	NV[2TmlvPzJiaB?=		NH;NdI5{cWewaX\pZ4FvfGy7IHnu[JVk\XNiYYDvdJRwe2m\|	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOEWyN{c,OjN2MUi1NlM9N2F-
K033	MWXGeY5kfGmxbjDBd5NigQ>?	M2\nVVI2OCCwTR?=	MXeyOEBp		NUK1OFRDcW6mdXPld{BiKG2xZHXzeEBqdmO{ZXHz[UBqdiCJMTDwc5B2dGG2aX;u	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOEWyN{c,OjN2MUi1NlM9N2F-
M23	M1;hdGZ2dmO2aX;uJGF{e2G7	M4j4RlI2OCCwTR?=	MnzRNlQhcA>?		MmTjbY5lfWOnczDHNUBidmRiR{KvUUBienKnc4S=	NICzNIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxPFUzOyd-MkO0NVg2OjN:L3G+
K029	M{i0UGZ2dmO2aX;uJGF{e2G7	M3PJb\|I2OCCwTR?=	NHH1XWEzPCCq		NX\lfnF{cW6mdXPld{BIOSCjcoLld5Q>	MnXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUi1NlMoRjJ\|NEG4OVI{RC:jPh?=
K028	M3nPZWZ2dmO2aX;uJGF{e2G7	MW[yOVAhdk1?	NEfGWZozPCCq		NWGwOYhocW6mdXPld{BIOiCjcoLld5Q>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOEWyN{c,OjN2MUi1NlM9N2F-
K008	M3Pzd2Z2dmO2aX;uJGF{e2G7	NWTUW\|h1OjVyIH7N	NYr6[5hJOjRiaB?=		MmXlbY5lfWOnczDHNkBienKnc4S=	NISxZ2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxPFUzOyd-MkO0NVg2OjN:L3G+
K033	MWfD[YxtKF[rYXLpcIl1gSCDc4PhfS=>				M13NOGlEPTB;N{WuOUBvVQ>?	NF3PR4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxPFUzOyd-MkO0NVg2OjN:L3G+
M23	NV;1SndzS2WubDDWbYFjcWyrdImgRZN{[Xl?				MWLJR\|UxRTN5LkWgcm0>	Mm\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUi1NlMoRjJ\|NEG4OVI{RC:jPh?=
K029	M3H0cWNmdGxiVnnhZoltcXS7IFHzd4F6				NGXhNopKSzVyPUS2JI5O	MonYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUi1NlMoRjJ\|NEG4OVI{RC:jPh?=
K028	M32xR2NmdGxiVnnhZoltcXS7IFHzd4F6				NYWzbpk2UUN3ME24OEBvVQ>?	NEjJXlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxPFUzOyd-MkO0NVg2OjN:L3G+
K008	MnjTR4VtdCCYaXHibYxqfHliQYPzZZk>				MljhTWM2OD14MDDuUS=>	M1PVXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEG4OVI{Lz5{M{SxPFUzOzxxYU6=
H3122	M2L3UWNmdGxiVnnhZoltcXS7IFHzd4F6	M1u1clAuOTByMDDuUS=>	NULsOGJMPzJiaB?=		MVHJR\|UxRTFyIH7N	Mm\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{OyOlUoRjJ\|NUOzNlY2RC:jPh?=
H2228	MXnD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NFG1V5oxNTFyMECgcm0>	NIfubpc4OiCq		MlX0TWM2OD1zMzDuUS=>	NXzpR\|U5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N\|MzPjVpPkKzOVM{OjZ3PD;hQi=>
A1847	M3jhPGFxd3C2b4Ppd{BCe3OjeR?=	NWKxNXR6OTBvMUCwJI5O	NWHF[I9qOjRxNEivO\|IhcA>?		NF:3R3JqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nIHHu[EBld3OnIHTldIVv\GWwdHz5	NIW2TYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mwNFE{Pid-MkO5NFAyOzZ:L3G+
OVCAR-8	MYXBdI9xfG:\|aYOgRZN{[Xl?	MojQNVAuOTByIH7N	M3vEW\|I1NzR6L{eyJIg>		MW\pcoR2[2W\|IHHwc5B1d3OrczD0bY1mKGGwZDDkc5NmKGSncHXu[IVvfGy7	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlyMEGzOkc,OjN7MECxN\|Y9N2F-
OVCAR-5	MojDRZBweHSxc3nzJGF{e2G7	MUmxNE0yODBibl2=	NXmxNHU6OjRxNEivO\|IhcA>?		M4P1TYlv\HWlZYOgZZBweHSxc3nzJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62bIm=	M3TwflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUCwNVM3Lz5{M{mwNFE{PjxxYU6=
SKOV-3	M{LkOmNmdGxiVnnhZoltcXS7IFHzd4F6	NHzVTYwxNTFyMECgcm0>	Mlv3O\|IhcA>?		MnP5bY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>?	NH;uNnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mwNFE{Pid-MkO5NFAyOzZ:L3G+
A1847	NHW0c3BE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	M4fPclAuOTByMDDuUS=>	NW\XSYx5PzJiaB?=		M4jxXYlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl?	NFS3e5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mwNFE{Pid-MkO5NFAyOzZ:L3G+
OVCAR-8	MUPD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	MmD3NE0yODByIH7N	NH3kRoc4OiCq		MkDYbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>?	NFTqNFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mwNFE{Pid-MkO5NFAyOzZ:L3G+
OVCAR-5	NX[3XphQS2WubDDWbYFjcWyrdImgRZN{[Xl?	MXiwMVExODBibl2=	MoLuO\|IhcA>?		NX7PT\|VmcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?=	Mn;mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MECxN\|YoRjJ\|OUCwNVM3RC:jPh?=
H146	MkDhSpVv[3Srb36gRZN{[Xl?	M2C4fFMxKG6P	Mor5O\|IhcA>?		Ml7HbY5lfWOnczDw[ZJ{cXO2ZX70JGczN01icHjhd4Uh[XK{ZYP0	M3XKd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MU[2OVA2Lz5{NEG2OlUxPTxxYU6=
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H82	MkPhSpVv[3Srb36gRZN{[Xl?	NVfSNJR6OzBibl2=	M2ewSFczKGh?		NFO2RohqdmS3Y3XzJJBmenOrc4TlcpQhTzJxTTDwbIF{\SCjcoLld5Q>	NVPyOFJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxOlY2ODVpPkK0NVY3PTB3PD;hQi=>
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H1173	MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWTQOG4xUUN3ME2xNk43OiCwTR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF4NkWwOUc,OjRzNk[1NFU9N2F-
H792	NXXwWWVsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXS1TlFrUUN3ME20OU4xPyCwTR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF4NkWwOUc,OjRzNk[1NFU9N2F-
H620	M1\vfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXLPflAxUUN3ME2zNk43PyCwTR?=	NIruR5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG2OlUxPSd-MkSxOlY2ODV:L3G+
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H526	M1LJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;TcWlEPTB;MkGuOlQhdk1?	NGL5N209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG2OlUxPSd-MkSxOlY2ODV:L3G+
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MDA-MB-231	MXLGeY5kfGmxbjDBd5NigQ>?	Ml3LNVAxKG6P	MX2yOEBp		M2PjNIlvcGmkaYTzJJRp\SCvaXfyZZRwenliYX7kJIlvfmG\|aY\lJINieGGlaYT5xsA>	M2fkS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUezOVQyLz5{NEG3N\|U1OTxxYU6=
BT-20	NHvMUFhHfW6ldHnvckBCe3OjeR?=	M{nLV\|ExOC9{NUCgcm0>	M370WFI1KGh?		NYjvWJV5emW\|dXz0[YQhcW5iYTDkc5NmNWSncHXu[IVvfCCmZYP0ZYJqdGm8YYTpc44hd2ZiRVfGVkwhUUeILVnSMEBOTVRuIHHu[EBEWkGI	M33C[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUezOVQyLz5{NEG3N\|U1OTxxYU6=
MDA-MB-435	MonpSpVv[3Srb36gRZN{[Xl?	MUmxNFAhdk1?	MkfYN\|AhdWmw		Mm\BbY5pcWKrdIOgZYNkfW23bHH0bY9vKG:oIFjJSk0y\|rF?	MoC4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NEiyOlUoRjJ2MkS4NlY2RC:jPh?=
MDA-MB-231	MoXuSpVv[3Srb36gRZN{[Xl?	MWWxNFAhdk1?	M3KyPVMxKG2rbh?=		M3fER4lvcGmkaYTzJIFk[3WvdXzheIlwdiCxZjDITWYuOc7z	NHG0NJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK0PFI3PSd-MkSyOFgzPjV:L3G+
HCC2998	MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTF{ODDuUS=>	M4XKcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkiyO\|Q4Lz5{NE[4Nlc1PzxxYU6=
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LS-123	MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3vlSWlEPTB;N{Ogcm0>	NILhNYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4Nlc1Pyd-MkS2PFI4PDd:L3G+
SNU-C2B	NInlcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{fBdWlEPTB;NEWgcm0>	NIntc4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4Nlc1Pyd-MkS2PFI4PDd:L3G+
LS-1034	NITlTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIS0UWRKSzVyPUOxJI5O	NEO1SVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4Nlc1Pyd-MkS2PFI4PDd:L3G+
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SJ-GBM2	MkLLdWhVWyCjc4PhfS=>				MoLYdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO=	M4T1VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	NXjBUVJveUiWUzDhd5NigQ>?				MWjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	NHXERmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	NWS1PGZReUiWUzDhd5NigQ>?				MVvxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	M3\hXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5	NIHOfmNyUFSVIHHzd4F6				M3vSPZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	M320SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	MoDsdWhVWyCjc4PhfS=>				NWXXdVlSeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO=	M3\rfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	EGFR / c-Met / IGF-1Rβ/ Akt / p-Akt / ERK / p-ERK ; p27(Kip1) / p21 (Cip1) / Cyclin D1 / Cyclin E / Cyclin B1 / CDK1 / CDK2 / CDK4 ; Survivin / Bcl-2 / Bcl-xl / Mcl-1 ; B-RAF / C-RAF / N-RAS ; HER2 / p-STAT3 / BIM ; CDK1 / Cyclin D1 / Cyclin B1 / p27 ; c-PARP / c-caspase 3 / caspase 8 / c-caspase 8 / caspase 9 / c-caspase 9 ; ErbB2 / pErbB2 / Src / pSrc / mTOR / pmTOR / Bad / pBad / GSK3 / pGSK3 ; Wee1 / p-Wee1 / Chk1 / p-Chk1	23418523 25077897 29717218 27834954
Growth inhibition assay	Cell viability	23418523

In vivo

Administration of Ganetespib leads to significant tumor shrinkage in several tumor xenograft models in mice and appears to be less toxic. Furthermore Ganetespib demonstrated better tumor penetration compared with tanespimycin.^[2] Ganetespib inhibits in vivo tumor growth in both malignant mast cell and OSA xenograft models. Ganetespib significantly inhibits tumor growth when dosed with two repeating cycles of 25 mg/kg/day for 3 days, with a %T/C value of 18. Ganetespib is well-tolerated, with the vehicle and Ganetespib groups having average bodyweight changes relative to the start of the study of +0.3% and -8.1% on day 17, respectively.^[4]

Protocol (from reference)

Cell Research:^[1]

Cell lines: OSA cells
Concentrations: 0.001-1μM
Incubation Time: 5 days
Method: A total of 1.5 × 10³ OSA cells are seeded in 96-well plates in 10% serum-containing complete medium and incubated overnight to determine the 50% inhibitory concentrations. Plates are, harvested at day 5 following 0.001, 0.005, 0.01, 0.05, 0.1, 0.5 and 1 μM Ganetespib, treatment and analyzed. Fluorescence measurements are made using a plate reader with excitation at 485 nm and emission detection at 530 nm. Relative cell number is calculated as a percentage of the control wells: absorbance of sample/absorbance of DMSO treated cells × 100.
(Only for Reference)

Animal Research:^[4]

Animal Models: Female severe combined immune-deficient (SCID) mice
Dosages: 25 mg/kg/day for 3 days
Administration: Tail vein injection
(Only for Reference)

References

[4] Lin TY, et al. Exp Hematol. 2008, 36(10), 1266-1277.

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Solubility (25°C)

In vitro	DMSO	40 mg/mL (109.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order (Data is from Selleck tests instead of citations): 5% DMSO+45% PEG 300+ddH2O For best results, use promptly after mixing. Click to purchase: PEG300	11mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	364.4
Formula	C₂₀H₂₀N₄O₃
CAS No.	888216-25-9
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O

Download Ganetespib (STA-9090) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02192541	Terminated	Drug: Ziv-Aflibercept\|Drug: Ganetespib	Neoplasms	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	December 2 2014	Phase 1
NCT02008877	Completed	Drug: ganetespib\|Drug: Sirolimus	Malignant Peripheral Nerve Sheath Tumors (MPNST)\|Sarcoma	Sarcoma Alliance for Research through Collaboration\|Synta Pharmaceuticals Corp.\|United States Department of Defense	December 2013	Phase 1\|Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Frequently Asked Questions

Question 1:
Does this inhibitor inhibit both isoforms of HSP90?

Answer:
We don't have the information now and it is not very clear in the literature either. From following two references, it indicates that Ganetespib might be specific to the alpha form “Ganetespib binds to the ATP binding site of Hsp90 alpha with a Kd of 110 nM” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477583/

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