Resveratrol

Catalog No.S1396

Resveratrol Chemical Structure

Molecular Weight(MW): 228.24

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
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USD 170 In stock
USD 310 In stock
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Cited by 17 Publications

2 Customer Reviews

  • Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.

    Dr. Johanna Weiss of University Hospital Heidelberg. Resveratrol purchased from Selleck.

  • PC-9 and A549 cells were treated with 100 nM siRNA against PUMA and 100 nM negative control (NC) siRNA for 12 h, and treated with the indicated concentrations of RV and ERL in combination for an additional 48 h. The knockdown effects on PUMA were confirmed by Western blot analysis.

    Cell Physiol Biochem, 2015, 35: 2255-2271 . Resveratrol purchased from Selleck.

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells NUjvXoRNWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1LsflQ5KGh? MmXsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:Oi5{NXWtNFUh|ryP MYKyNVg2OTB6Mx?=
human SK-N-SH cells MlexVJJwdGmoZYLheIlwdiCjc4PhfS=> MVO0PEBp MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLV6tV2gh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD12LkCz[U0xPQ>? MYOyNVg2OTB6Mx?=
human A549 cells MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 NUPoTHZ1PDhiaB?= NX3VdlFJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND60O4UuODV? NH;CSHozOTh3MUC4Ny=>
human MCF7 cells MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 MlnNOFghcA>? MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjlzZT2wOS=> MXiyNVg2OTB6Mx?=
HEK293 cells NWHKd4dKTnWwY4Tpc44h[XO|YYm= M2jsVlQ5KGh? MYHJcohq[mm2aX;uJI9nKFSQRj3hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4Tpeol1gSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5zN{Og{txO MnyzNlA2Ojd6OUG=
RAW264.7 cells M3q5SWZ2dmO2aX;uJIF{e2G7 NYLPTHd{UW6qaXLpeI9zgSCnZn\lZ5Qhd25iUFfFMVIheHKxZIXjeIlwdiCrbjDMVHMue3SrbYXsZZRm\CCUQWeyOlQvPyClZXzsd{whUUN3ME20JO69VQ>? MYOxOVA5ODl6OB?=
mouse HT22 cells MWXGeY5kfGmxbjDhd5NigQ>? MV:yOEBp MnfXUoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHnuJI1wfXOnIFjUNlIh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KGeudYThcYF1\S2rbnT1Z4VlKG:6eYTvd4l{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> NEP3XHozOTF{OUm3PC=>
human HL60 cell line MX3Qdo9tcW[ncnH0bY9vKGG|c3H5 MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdCCuaX7lMEBKSzVyPUWg{txO NHnLSWYyPjZ6NkW0Ny=>
human Huh7.5.1 cells NHLHW2JEgXSxdH;4bYPDqGG|c3H5 NIHZdpc4OiCq MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg4NjVwMTDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MUCuOkDPxE1? M17Ec|I{Pjd|MkK1
mouse Hepa1clc7 cells Mn;DR5l1d3SxeHnjxsBie3OjeR?= MlrVO|IhcA>? M4rYS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGhmeGFzY3zjO{Bk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9NVEh|ryP M1nZe|ExODd3N{Sy
human H460 cells M1TKXXBzd2yrZnXyZZRqd25iYYPzZZk> M1jnNlczKGh? NVLNW25PSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0yOi57IN88US=> NW\ZeYxvOjB2MEm3NlM>
human 293 cells MoC0SpVv[3Srb36gZZN{[Xl? M4[0O|I1KGh? NH;WXmZKdmirYnn0bY9vKG:oIGTOSoFteGijIHnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hcHWvYX6gNlk{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NVYvOSEQvF2= Mk\rNVg1QDdyNUO=
human U937 cells MV;DfZRwfG:6aXRCpIF{e2G7 M3XHbFQ5KGh? MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDXV3QyKHSnc4SsJGlEPTB;MUeg{txO NHPCWYwyPjJ3MkmyOC=>
human MCF7 cells MVrGeY5kfGmxbjDhd5NigQ>? NU\4ZZRXPiCq NWLXcpl[UW6qaXLpeIlwdiCxZjDwbI9z[m:uIHXzeIVzNWmwZIXj[YQhd3KwaYTobY5mKGSnY3HyZo95gWyjc3WgbY4hcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC2JIhzeyxiSVO1NF0yQSEQvF2= M2LZT|ExODd3N{Sy
HEK293T cells NInP[m1HfW6ldHnvckBie3OjeR?= MkfrTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBJTUt{OUPUJINmdGy|LDDJR|UxRTJyIN88US=> MX[xO|EzPTJ5MB?=
human SW480 cells NHv2VGxRem:uaX\ldoF1cW:wIHHzd4F6 M3ixOFQ5KGh? NYPkc|NESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUB2e2mwZzDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHHmeIVzKDR6IHjyd{whUUN3ME2yNEDPxE1? NWnDVYk{OjB|OUWwNVk>
human MDA-MB-231 cells NIPHTIJHfW6ldHnvckBie3OjeR?= Mor6OkBl[Xm| NHzNPVhCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCVUlKgZZN{[XluIFnDOVA:OjBwNTFOwG0> M3jIb|IxPzJ6M{[5
human COLO205 cells M1jpNHBzd2yrZnXyZZRqd25iYYPzZZk> NF7ze5pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPPUG8zODViY3XscJMh[nliTWTUJIF{e2G7IDygTWM2OD1{Mz61JO69VQ>? MYCyOVQ2PTR6Nh?=
mouse NIH/3T3 cells MlT2R5l1d3SxeHnjxsBie3OjeR?= Mk\6PVYhcA>? NXrWdVJ2S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTJ2LkKyJO69VQ>? M{LkRVIzPzR7M{my
human Caco-2 cells NYTrTlFTS3m2b4TvfIlkyqCjc4PhfS=> NFjv[ms{KGSjeYO= MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JHs{UF22aIntbYRqdmViaX7jc5Jxd3KjdHnvckBie3OjeR?= Mo\NNlA3Ojd|N{m=
human K562 cell line MnzUVJJwdGmoZYLheIlwdiCjc4PhfS=> M4TUT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuIHzpcoUh\XiycnXzd4lv\yCEY4KtRYJtNCCLQ{WwQVI5KM7:TR?= NWj0VHhROTZ4OE[1OFM>
MCF7 cells M2XwcGN6fG:2b4jpZ:Kh[XO|YYm= NIjjdYw4OiCq MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDwc5NqfGm4ZTDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYpvwKwhUUN3ME2yPE4xPyEQvF2= NEX5VmczOzh4MEW5NC=>
mouse 3T3L1 cells NHraT2NHfW6ldHnvckBie3OjeR?= MnTDO{Bl[Xm| M{fwfWFvfGmjZHnwc4dmdmmlIHHjeIl3cXS7IHHnZYlve3RibX;1d4UhO1R|TEGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCmaX\m[ZJmdnSrYYTpc44h[W[2ZYKgO{Bl[Xm|IHL5JI9qdC2{ZXSgU{B{fGGrbnnu[{whUUN3ME2zNU41KM7:TR?= NEHlTWMyQTd3N{i1Ny=>
human HeLa cells NYriVYlZTnWwY4Tpc44h[XO|YYm= NWmyNVRwOzBibXnudy=> MnzoTY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdicHH0bJdigSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiUF3BJIlv\HWlZXSgcJVkcW[ncnHz[UB1emWjdHXkJFMxKG2rboOgZoVnd3KnIHnu[JVkfGmxbh?= Ml7JNlM2PDd6NEO=
human HT144 cells M3jvbnBzd2yrZnXyZZRqd25iYYPzZZk> NWXkeXg2PSCmYYnz NWHiXmVLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWFE1PCClZXzsd{Bi\nSncjC1JIRigXNiYomgZYNq\CCyaH;zdIhifGG|ZTDhd5Nige,:jDDJR|UxRTRyIN88US=> NVzhS2J{OTl2OEG0OlI>
SKBR3 cells NH7uNmtEgXSxdH;4bYPDqGG|c3H5 Mn\pO|IhcA>? MoHkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4KgcoVo[XSrdnWgV2tDWjNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4Phfg+9lCCLQ{WwQVQyNjR{IN88US=> NEfLSmwzOzh4MEW5NC=>
human MGC803 cells MmjmVJJwdGmoZYLheIlwdiCjc4PhfS=> NHXpTVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:PDJizszN NHLSPVkzPTR3NUS4Oi=>
human MDA468 cells NH3Y[4hRem:uaX\ldoF1cW:wIHHzd4F6 M1Trb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBOFY5KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF01PS5{IN88US=> M3zyb|I2PDV3NEi2
human HT-29 cells MmrRR5l1d3SxeHnjxsBie3OjeR?= NF32enQ{KGSjeYO= MmXjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JHs{UF22aIntbYRqdmViaX7jc5Jxd3KjdHnvckBie3OjeTygTWM2OD12NT6zJO69VQ>? NWLSN3VrOjB4MkezO|k>
human SK-MEL cells M3nZPWN6fG:2b4jpZ:Kh[XO|YYm= M3\zb|Q5KGh? MljWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XoxvJygTWM2OD12Nz6zJO69VQ>? MY[yN|U1Pzh2Mx?=
human SH-SY5Y cells MXHGeY5kfGmxbjDhd5NigQ>? MXTO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIFiyU|IucW6mdXPl[EBz\WS3Y4Tpc44hd2ZiY3XscEB3cWGkaXzpeJkh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JJBp[XOnLXPvcpRz[XO2IH3pZ5Jw\3KjcHigZY5idHm|aYO= M3OxZ|I1OjZ7NUG1
HUVEC M3;VPWZ2dmO2aX;uJIF{e2G7 NVLKdFk1OTByIN88US=> M1rPbFEh\GG7 Mn;1TY5lfWO2aX;uJI9nKG2rdH;jbI9v\HKrYXygZolw\2WwZYPpd{BqdiCKMl:yMYlv\HWlZXSgTHVXTUNiYYSgNVAxKHWvb3yvUEBxemW2cnXheIVlKG[xcjCxJIRigSCob3zsc5dm\CCkeTDjc41xd3WwZDD3ZZNpd3W2IHHu[EBJOk9{LYTy[YF1dWWwdDDt[YF{fXKnZDDh[pRmeiBzMDDkZZl{KGK7IF3peI9VemGla3XyJHJm\CC|dHHpcolv\y2kYYPl[EBie3OjeR?= NGrofZMzOzh3OUK0PS=>
human SW480 cells NVmxNXdVS3m2b4TvfIlkyqCjc4PhfS=> MXqxNEDPxE1? MmCzNkBl[Xm| MlnDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c1QDBiY3XscJMh[XRiMUCgeW0h\m:{IEKg[IF6eyCkeTD2bU1k\WyuIHPlcIwhfmmjYnnsbZR6KGGwYXz5d4l{ NIT0[oIzOTJ7MUKzOS=>
human LS 174T cells MYLDfZRwfG:6aXRCpIF{e2G7 NIDrOGQyOCEQvF2= MU[0JIRigXN? NXfPSVAxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFNiMUe0WEBk\WyuczDheEAyOCC3TTDmc5IhPCCmYYnzJIJ6KH[rLXPlcIwh[2WubDD2bYFjcWyrdImgZY5idHm|aYO= MYKyNVI6OTJ|NR?=
human CCD-18Co cells MYfGeY5kfGmxbjDhd5NigQ>? M4\TbVEh|ryP MYmxPEBp MnnURY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDDR2QuOTiFbzDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJGlNOWKndHGtbY5lfWOnZDDQS2UzKHC{b3T1Z5Rqd25iYYSgNUB2VSCjZoTldkAyQCCqcoO= NW\wfnFSOjB6Nk[wN|I>
mouse C2C12 cells Ml\KSpVv[3Srb36gZZN{[Xl? NVTHUoxbPTBizszN NY\LNIl[OTZiaB?= NV7lWHN3UW6lcnXhd4UhcW5ibXn0c4Npd26mcnnhcEBnfW6ldHnvckBqdiCvb4Xz[UBEOkNzMjDj[YxteyCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBw\iCvaYTvZ4hwdmS{aXHsJIRmdnOrdImgZZQhPTBidV2gZYZ1\XJiMU[gbJJ{KGK7IHfy[YVvKE[PIHT5[UB{fHKjaX7pcocu[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5 NUDsTmdjOTl4NkO0PVg>
human H460 cells NF6wcZRHfW6ldHnvckBie3OjeR?= MYmyNEDPxE1? MkPPNlQhcA>? MX\D[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDIOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOi:PIIDoZZNmKGG2IEKwJJVOKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\sc5ch[3m2b33leJJ6 NHL5eXAzODRyOUeyNy=>
mouse MC3T3-E1 cells NEXaUnNCeG:ydH;zbZMh[XO|YYm= MVqxJO69VQ>? NHzBd2k1QCCq NV72eYMzUW6qaXLpeIlwdiCxZjDhcpRq[XCxcITveIlkKGGldHn2bZR6KGmwIH3veZNmKE2FM2SzMWUyKGOnbHzzJIF1KDFidV2gZYZ1\XJiNEigbJJ{KGmwIIDy[ZNmdmOnIH;mJGJOWDJvc4DlZ4lncWNibnX1eJJidGm8aX7nJIFvfGmkb3T5 MkDpNVc2OTN6Nke=
human THP1 cells NIDxOY5HfW6ldHnvckBie3OjeR?= MnXENVAxKM7:TR?= MXOxJIg> MW\Jcohq[mm2aX;uJI9nKE[VTEGtbY5lfWOnZDD1dJJm\3WuYYTpc44hd2ZiZHXjeIlvNTFibWLORUBmgHC{ZYPzbY9vKGmwIHnuJIh2dWGwIGTIVFEh[2WubIOgZZQhOTByIIXNJIFnfGW{IEGgbJIh[nliUmStVGNT M2jJPFE4QTN6MUi3
human T47D cells M4P5UnBzd2yrZnXyZZRqd25iYYPzZZk> NYCzNI9sOSEQvF2= MlHhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWNEfEJINmdGy|IHH0JFEhfU1iYomg[oxwfyCleYTvcYV1enl? Ml7uNVc2OTN6Nke=
human MG63 cells MkPBSpVv[3Srb36gZZN{[Xl? MmjINE4yKHSxIEGwJJVO M{fTelch\GG7cx?= M{PXeGlv[3KnYYPlJIlvKEGOUDDhZ5Rqfmm2eTDpckBpfW2jbjDNS|Y{KGOnbHzzJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB5IHThfZM> M{Dib|E4PTF|OE[3
human U2OS cells NU\OS3JoTnWwY4Tpc44h[XO|YYm= MXmxNFAh|ryP M4PQdmFkfGm4YYTpc44hd2ZiU1nSWFEhcW5iaIXtZY4hXTKRUzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBxPTNiZHXhZ4V1gWyjdHnvckBt\X[nbDDheEAyODBidV2= MX[xPFA1PjRyOR?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Nanog / Oct-4 / Sox-2 ; 

PubMed: 21304978     


Pancreatic CSCs were treated with resveratrol (0–30 µM) for 48 h. The expression of Nanog, Oct-4 and Sox-2 was measured by the Western blot analysis. GAPDH was used as a loading control. 

p-EGFR / EGFR / p-HER2 / HER2 / p-ERK / ERK / PTEN ; 

PubMed: 20729295     


DU145 cells were treated with DMSO, and 10, 20 or 50 µm resveratrol. Western blots show resveratrol decreased phosphorylation of EGFR-Tyr1068 (upper panel), HER2-Tyr1221/1222 (second panel).

21304978 20729295
Growth inhibition assay
Cell viability; 

PubMed: 23272133     


A, MTS assay was performed on PC-3M-MM2 cells treated with vehicle or different concentrations of resveratrol (5–100 µM) for 72 h which showed that resveratrol dose-dependently reduced cell viability. B, Decrease in cell viability by resveratrol was time-dependent in the resveratrol-treated groups (25 and 50 µM) compared to vehicle.

23272133
In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

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  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

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  • Animal Models: Human ovarian xenografts PA-1
  • Formulation: Solution in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03743636 Recruiting Drug: Nicotinamide riboside|Drug: Resveratrol|Other: Placebo Peripheral Artery Disease Northwestern University|American Heart Association October 1 2018 Phase 3
NCT03253913 Recruiting Drug: Sirolimus|Drug: Resveratrol Lymphangioleiomyomatosis University of Cincinnati|National Heart Lung and Blood Institute (NHLBI) March 31 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID