Resveratrol

Catalog No.S1396

Resveratrol Chemical Structure

Molecular Weight(MW): 228.24

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 310 In stock
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Cited by 14 Publications

2 Customer Reviews

  • Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.

    Dr. Johanna Weiss of University Hospital Heidelberg. Resveratrol purchased from Selleck.

  • PC-9 and A549 cells were treated with 100 nM siRNA against PUMA and 100 nM negative control (NC) siRNA for 12 h, and treated with the indicated concentrations of RV and ERL in combination for an additional 48 h. The knockdown effects on PUMA were confirmed by Western blot analysis.

    Cell Physiol Biochem, 2015, 35: 2255-2271 . Resveratrol purchased from Selleck.

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells M4j2[nBzd2yrZnXyZZRqd25iYYPzZZk> NGnzOHE1QCCq MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjJ3ZT2wOUDPxE1? M{HsOVIyQDVzMEiz
human SK-N-SH cells M2DQ[nBzd2yrZnXyZZRqd25iYYPzZZk> MU[0PEBp NIjJS3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW4uW0hiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlA{\S1yNR?= MWSyNVg2OTB6Mx?=
human A549 cells M{j1eHBzd2yrZnXyZZRqd25iYYPzZZk> NGrWNIc1QCCq NX\6eZFwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND60O4UuODV? Mnm4NlE5PTFyOEO=
human MCF7 cells NGHSTllRem:uaX\ldoF1cW:wIHHzd4F6 MVe0PEBp Mmj2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:Py57MXWtNFU> MoHENlE5PTFyOEO=
HEK293 cells MX\GeY5kfGmxbjDhd5NigQ>? M3m4T|Q5KGh? NXy1d25NUW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDOSk1s[XCyYVKgZYN1cX[rdImg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDh[pRmeiB2ODDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNVc{KM7:TR?= M1nTZlIxPTJ5OEmx
RAW264.7 cells NGDSfIJHfW6ldHnvckBie3OjeR?= NYfIbox3UW6qaXLpeI9zgSCnZn\lZ5Qhd25iUFfFMVIheHKxZIXjeIlwdiCrbjDMVHMue3SrbYXsZZRm\CCUQWeyOlQvPyClZXzsd{whUUN3ME20JO69VQ>? MUCxOVA5ODl6OB?=
mouse HT22 cells M2npTGZ2dmO2aX;uJIF{e2G7 MUWyOEBp MnGxUoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHnuJI1wfXOnIFjUNlIh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KGeudYThcYF1\S2rbnT1Z4VlKG:6eYTvd4l{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> NFLob|YzOTF{OUm3PC=>
human HL60 cell line NYnBSlYyWHKxbHnm[ZJifGmxbjDhd5NigQ>? NUO0TIxYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHygcIlv\SxiSVO1NF02KM7:TR?= MkDJNVY3QDZ3NEO=
human Huh7.5.1 cells M3TySGN6fG:2b4jpZ:Kh[XO|YYm= NVjUTWFXPzJiaB?= NIXvTGJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWh5LkWuNUBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9NVAvPiEQvF2= MYWyN|Y4OzJ{NR?=
mouse Hepa1clc7 cells NHvWRoJEgXSxdH;4bYPDqGG|c3H5 MnHyO|IhcA>? NV;0d3RGS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUGWyYUHjcIM4KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0yOSEQvF2= MXKxNFA4PTd2Mh?=
human H460 cells MUnQdo9tcW[ncnH0bY9vKGG|c3H5 MV:3NkBp NXfZPGJbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0yOi57IN88US=> NYSyTIpKOjB2MEm3NlM>
human 293 cells NXv1VlM{TnWwY4Tpc44h[XO|YYm= MXyyOEBp NEKwZllKdmirYnn0bY9vKG:oIGTOSoFteGijIHnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hcHWvYX6gNlk{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NVYvOSEQvF2= NHzTd5kyQDR6N{C1Ny=>
human U937 cells M2DoVmN6fG:2b4jpZ:Kh[XO|YYm= NXzqOGp5PDhiaB?= NEfGPJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBYW1RzIITld5QtKEmFNUC9NVch|ryP M4nFd|E3OjV{OUK0
human MCF7 cells MVzGeY5kfGmxbjDhd5NigQ>? M2\KPFYhcA>? MWnJcohq[mm2aX;uJI9nKHCqb4Lic4wh\XO2ZYKtbY5lfWOnZDDvdo5qfGirbnWg[IVk[XKkb4j5cIF{\SCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDZiaILzMEBKSzVyPUG5JO69VQ>? Mn63NVAxPzV5NEK=
HEK293T cells M4nud2Z2dmO2aX;uJIF{e2G7 MnnHTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBJTUt{OUPUJINmdGy|LDDJR|UxRTJyIN88US=> NFv3c5cyPzF{NUK3NC=>
human SW480 cells NXPRNY9QWHKxbHnm[ZJifGmxbjDhd5NigQ>? NGPYWYU1QCCq NInwVGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JJV{cW6pIIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdiYX\0[ZIhPDhiaILzMEBKSzVyPUKwJO69VQ>? MnPTNlA{QTVyMUm=
human MDA-MB-231 cells M3fST2Z2dmO2aX;uJIF{e2G7 MWW2JIRigXN? NEXDR2RCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCVUlKgZZN{[XluIFnDOVA:OjBwNTFOwG0> MUCyNFczQDN4OR?=
human COLO205 cells MnXTVJJwdGmoZYLheIlwdiCjc4PhfS=> NXfLSVVFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGK7IF3UWEBie3OjeTCsJGlEPTB;MkOuOUDPxE1? NIrnVVIzPTR3NUS4Oi=>
mouse NIH/3T3 cells NVu3OVM3S3m2b4TvfIlkyqCjc4PhfS=> NEfqVWc6PiCq NWK3VFhXS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVkmKL{PUN{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTJ2LkKyJO69VQ>? NVrXdpZUOjJ5NEmzPVI>
human Caco-2 cells NW\OTXZWS3m2b4TvfIlkyqCjc4PhfS=> NGPPTIc{KGSjeYO= NFv6V3FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxLUKgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfS=> MV:yNFYzPzN5OR?=
human K562 cell line MUnQdo9tcW[ncnH0bY9vKGG|c3H5 NHXVclVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubDDsbY5mKGW6cILld5NqdmdiQnPyMWFjdCxiSVO1NF0zQCEQvF2= Mn7INVY3QDZ3NEO=
MCF7 cells MXLDfZRwfG:6aXRCpIF{e2G7 NF7veZA4OiCq M3:4fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJJBwe2m2aY\lJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4Phfg+9lCCLQ{WwQVI5NjB5IN88US=> MWGyN|g3ODV7MB?=
mouse 3T3L1 cells M{PjcmZ2dmO2aX;uJIF{e2G7 MoDTO{Bl[Xm| MlPBRY51cWGmaYDv[4VvcWNiYXP0bZZqfHliYXfhbY5{fCCvb4Xz[UA{XDOOMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGSrZn\ldoVvfGmjdHnvckBi\nSncjC3JIRigXNiYomgc4ltNXKnZDDPJJN1[WmwaX7nMEBKSzVyPUOxMlQh|ryP M{XU[|E6PzV5OEWz
human HeLa cells NVTjU5c5TnWwY4Tpc44h[XO|YYm= NFrSPFQ{OCCvaX7z NHux[lJKdmirYnn0bY9vKG:oIFjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDQUWEhcW6mdXPl[EBtfWOrZnXyZZNmKHS{ZXH0[YQhOzBibXnud{Bj\W[xcnWgbY5lfWO2aX;u MmnVNlM2PDd6NEO=
human HT144 cells MUPQdo9tcW[ncnH0bY9vKGG|c3H5 NV;qTIIxPSCmYYnz NUjMOGprSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWFE1PCClZXzsd{Bi\nSncjC1JIRigXNiYomgZYNq\CCyaH;zdIhifGG|ZTDhd5Nige,:jDDJR|UxRTRyIN88US=> NH3DdGoyQTR6MUS2Ni=>
SKBR3 cells NGXTeY1EgXSxdH;4bYPDqGG|c3H5 NXqxcmF[PzJiaB?= M1ziUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJI5m\2G2aY\lJHNMSlJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZnwxIxiSVO1NF01OS52MjFOwG0> NX7OWo5TOjN6NkC1PVA>
human MGC803 cells NYrDWWg{WHKxbHnm[ZJifGmxbjDhd5NigQ>? MnXjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPR1O4NFMh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQzKM7:TR?= MlPZNlU1PTV2OE[=
human MDA468 cells MX\Qdo9tcW[ncnH0bY9vKGG|c3H5 M3e4SmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBOFY5KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF01PS5{IN88US=> MoD2NlU1PTV2OE[=
human HT-29 cells NWjNNVg5S3m2b4TvfIlkyqCjc4PhfS=> MnrsN{Bl[Xm| NX6zeWNiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME20OU4{KM7:TR?= NVK2O2FHOjB4MkezO|k>
human SK-MEL cells M{TGPGN6fG:2b4jpZ:Kh[XO|YYm= NE[4XG81QCCq MkDSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XoxvJygTWM2OD12Nz6zJO69VQ>? M1n5d|I{PTR5OESz
human SH-SY5Y cells MkfOSpVv[3Srb36gZZN{[Xl? M4frXG5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gTFJQOi2rbnT1Z4VlKHKnZIXjeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjdDCxNEB2VSCjZoTldkAzPCCqcoOgZpkheGijc3WtZ49vfHKjc4SgcYlkem:pcnHwbEBidmGueYPpdy=> M4\ofVI1OjZ7NUG1
HUVEC MlfOSpVv[3Srb36gZZN{[Xl? M{TrVlExOCEQvF2= MlfYNUBl[Xl? M{nDVmlv\HWldHnvckBw\iCvaYTvZ4hwdmS{aXHsJIJqd2enbnXzbZMhcW5iSELPNk1qdmS3Y3XkJGhWXkWFIHH0JFExOCC3bX;sM2wheHKndILlZZRm\CCob4KgNUBl[XliZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhUDKRMj30doVifG2nboSgcYVie3W{ZXSgZYZ1\XJiMUCg[IF6eyCkeTDNbZRwXHKjY3vldkBT\WRic4ThbY5qdmdvYnHz[YQh[XO|YYm= NV;a[pFqOjN6NUmyOFk>
human SW480 cells MWTDfZRwfG:6aXRCpIF{e2G7 M1TnXlExKM7:TR?= MnG3NkBl[Xm| MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTW|Q5OCClZXzsd{BifCBzMDD1UUBnd3JiMjDkZZl{KGK7II\pMYNmdGxiY3XscEB3cWGkaXzpeJkh[W6jbInzbZM> MkPDNlEzQTF{M{W=
human LS 174T cells MnHMR5l1d3SxeHnjxsBie3OjeR?= MXqxNEDPxE1? MoLQOEBl[Xm| MmLsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHMhOTd2VDDj[YxteyCjdDCxNEB2VSCob4KgOEBl[Xm|IHL5JJZqNWOnbHygZ4VtdCC4aXHibYxqfHliYX7hcJl{cXN? NVLufGVIOjF{OUGyN|U>
human CCD-18Co cells NYrPO2pITnWwY4Tpc44h[XO|YYm= M1X2bFEh|ryP M4P1SFE5KGh? MXLBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFPDSE0yQEOxIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[gTWwy[mW2YT3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiCjdDCxJJVOKGGodHXyJFE5KGi{cx?= MXqyNFg3PjB|Mh?=
mouse C2C12 cells M2DQTmZ2dmO2aX;uJIF{e2G7 NVrNc4d{PTBizszN MnPDNVYhcA>? NXXFOYp6UW6lcnXhd4UhcW5ibXn0c4Npd26mcnnhcEBnfW6ldHnvckBqdiCvb4Xz[UBEOkNzMjDj[YxteyCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBw\iCvaYTvZ4hwdmS{aXHsJIRmdnOrdImgZZQhPTBidV2gZYZ1\XJiMU[gbJJ{KGK7IHfy[YVvKE[PIHT5[UB{fHKjaX7pcocu[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5 MWmxPVY3OzR7OB?=
human H460 cells MXXGeY5kfGmxbjDhd5NigQ>? NVjHTlgxOjBizszN MWOyOEBp M1HpU2NmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEd{L12gdIhie2ViYYSgNlAhfU1iYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[oxwfyCleYTvcYV1enl? NWL4cGNHOjB2MEm3NlM>
mouse MC3T3-E1 cells NHTjZ4ZCeG:ydH;zbZMh[XO|YYm= NVvOXVU4OSEQvF2= MVe0PEBp MnTLTY5pcWKrdHnvckBw\iCjboTpZZBweHSxdHnjJIFkfGm4aYT5JIlvKG2xdYPlJG1EO1R|LVWxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIlvKHC{ZYPlcoNmKG:oIFLNVFIue3CnY3nmbYMhdmW3dILhcIl7cW6pIHHueIljd2S7 MVyxO|UyOzh4Nx?=
human THP1 cells MUXGeY5kfGmxbjDhd5NigQ>? NH;nT5cyODBizszN NF[5flAyKGh? NYrSZo5vUW6qaXLpeIlwdiCxZjDGV2wyNWmwZIXj[YQhfXC{ZXf1cIF1cW:wIH;mJIRm[3Srbj2xJI1TVkFiZYjwdoV{e2mxbjDpckBqdiCqdX3hckBVUFBzIHPlcIx{KGG2IEGwNEB2VSCjZoTldkAyKGi{IHL5JHJVNVCFUh?= Ml;TNVc6OzhzOEe=
human T47D cells NX7W[YNuWHKxbHnm[ZJifGmxbjDhd5NigQ>? MknCNUDPxE1? MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFR2N1SgZ4VtdHNiYYSgNUB2VSCkeTDmcI94KGO7dH;t[ZRzgQ>? MlHmNVc2OTN6Nke=
human MG63 cells MVXGeY5kfGmxbjDhd5NigQ>? MXGwMlEhfG9iMUCgeW0> NVT3W|R5PyCmYYnz M1zvWWlv[3KnYYPlJIlvKEGOUDDhZ5Rqfmm2eTDpckBpfW2jbjDNS|Y{KGOnbHzzJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB5IHThfZM> NHrhSJMyPzVzM{i2Oy=>
human U2OS cells NUfPc3JOTnWwY4Tpc44h[XO|YYm= MoLJNVAxKM7:TR?= Mo\ERYN1cX[jdHnvckBw\iCVSWLUNUBqdiCqdX3hckBWOk:VIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJA2OyCmZXHj[ZR6dGG2aX;uJIxmfmWuIHH0JFExOCC3TR?= M2jheFE5ODR4NEC5

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Nanog / Oct-4 / Sox-2 ; 

PubMed: 21304978     


Pancreatic CSCs were treated with resveratrol (0–30 µM) for 48 h. The expression of Nanog, Oct-4 and Sox-2 was measured by the Western blot analysis. GAPDH was used as a loading control. 

p-EGFR / EGFR / p-HER2 / HER2 / p-ERK / ERK / PTEN ; 

PubMed: 20729295     


DU145 cells were treated with DMSO, and 10, 20 or 50 µm resveratrol. Western blots show resveratrol decreased phosphorylation of EGFR-Tyr1068 (upper panel), HER2-Tyr1221/1222 (second panel).

21304978 20729295
Growth inhibition assay
Cell viability; 

PubMed: 23272133     


A, MTS assay was performed on PC-3M-MM2 cells treated with vehicle or different concentrations of resveratrol (5–100 µM) for 72 h which showed that resveratrol dose-dependently reduced cell viability. B, Decrease in cell viability by resveratrol was time-dependent in the resveratrol-treated groups (25 and 50 µM) compared to vehicle.

23272133
In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Human ovarian xenografts PA-1
  • Formulation: Solution in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03743636 Recruiting Drug: Nicotinamide riboside|Drug: Resveratrol|Other: Placebo Peripheral Artery Disease Northwestern University|American Heart Association October 1 2018 Phase 3
NCT03253913 Recruiting Drug: Sirolimus|Drug: Resveratrol Lymphangioleiomyomatosis University of Cincinnati|National Heart Lung and Blood Institute (NHLBI) March 31 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID