Resveratrol

For research use only.

Catalog No.S1396

32 publications

Resveratrol Chemical Structure

CAS No. 501-36-0

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 310 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Resveratrol has been cited by 32 publications

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells M1rCTnBzd2yrZnXyZZRqd25iYYPzZZk> MonFOFghcA>? NWTZRpYxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;Mj6yOYUuODVizszN NHnoSGMzOTh3MUC4Ny=>
human SK-N-SH cells MoPjVJJwdGmoZYLheIlwdiCjc4PhfS=> MoLrOFghcA>? MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLV6tV2gh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD12LkCz[U0xPQ>? MnjsNlE5PTFyOEO=
human A549 cells NX30fGRnWHKxbHnm[ZJifGmxbjDhd5NigQ>? NXXzdot1PDhiaB?= M2HOcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTRwNEflMVA2 MX:yNVg2OTB6Mx?=
human MCF7 cells NIfoc|lRem:uaX\ldoF1cW:wIHHzd4F6 NUDvOm9GPDhiaB?= M3flU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTdwOUHlMVA2 NETsbHEzOTh3MUC4Ny=>
HEK293 cells NXfOXJgxTnWwY4Tpc44h[XO|YYm= NXq5N3VlPDhiaB?= NV7EOZBNUW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDOSk1s[XCyYVKgZYN1cX[rdImg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDh[pRmeiB2ODDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNVc{KM7:TR?= NIHQdGszODV{N{i5NS=>
RAW264.7 cells NELONY9HfW6ldHnvckBie3OjeR?= MnzVTY5pcWKrdH;yfUBm\m[nY4Sgc44hWEeHLUKgdJJw\HWldHnvckBqdiCOUGOtd5RqdXWuYYTl[EBTSVd{NkSuO{Bk\WyuczygTWM2OD12IN88US=> MWOxOVA5ODl6OB?=
mouse HT22 cells NYjyfYhqTnWwY4Tpc44h[XO|YYm= MXuyOEBp MYTO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3i7dH;zbZMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> NXXmZms1OjFzMkm5O|g>
human HL60 cell line MXvQdo9tcW[ncnH0bY9vKGG|c3H5 NHu5UYZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubDDsbY5mNCCLQ{WwQVUh|ryP M4TkXVE3Pjh4NUSz
human Huh7.5.1 cells MonjR5l1d3SxeHnjxsBie3OjeR?= NGTCTJU4OiCq M1:0XGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cDdwNT6xJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2xNE43KM7:TR?= NGK0TWgzOzZ5M{KyOS=>
mouse Hepa1clc7 cells MkHDR5l1d3SxeHnjxsBie3OjeR?= NWH6TopoPzJiaB?= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDI[ZBiOWOuY{egZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGxJO69VQ>? Mkn6NVAxPzV5NEK=
human H460 cells NFjNV4NRem:uaX\ldoF1cW:wIHHzd4F6 MXi3NkBp MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEh2NkCgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGyMlkh|ryP MUCyNFQxQTd{Mx?=
human 293 cells MYTGeY5kfGmxbjDhd5NigQ>? NYjsNIlHOjRiaB?= NI\DeFlKdmirYnn0bY9vKG:oIGTOSoFteGijIHnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hcHWvYX6gNlk{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NVYvOSEQvF2= MYWxPFQ5PzB3Mx?=
human U937 cells MmPjR5l1d3SxeHnjxsBie3OjeR?= NGPDW2Y1QCCq MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDXV3QyKHSnc4SsJGlEPTB;MUeg{txO MmK2NVYzPTJ7MkS=
human MCF7 cells NHPU[WtHfW6ldHnvckBie3OjeR?= NX3uN3gxPiCq NHvFcIRKdmirYnn0bY9vKG:oIIDoc5Jjd2xiZYP0[ZIucW6mdXPl[EBwem6rdHjpcoUh\GWlYYLic5h6dGG|ZTDpckBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IE[gbJJ{NCCLQ{WwQVE6KM7:TR?= MlXKNVAxPzV5NEK=
HEK293T cells NITNfXRHfW6ldHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKFSQRj3hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4TpeoF1cW:wIHnuJGhGUzJ7M2SgZ4VtdHNuIFnDOVA:OjBizszN MYixO|EzPTJ5MB?=
human SW480 cells NGW2WINRem:uaX\ldoF1cW:wIHHzd4F6 NVXoXlB5PDhiaB?= MnXWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4NEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTD1d4lv\yCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oKGGodHXyJFQ5KGi{czygTWM2OD1{MDFOwG0> MV6yNFM6PTBzOR?=
human MDA-MB-231 cells MlOySpVv[3Srb36gZZN{[Xl? NGPMWoo3KGSjeYO= MW\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFYh\GG7czDifUBUWkJiYYPzZZktKEmFNUC9NlAvPSEQvF2= M{PDZVIxPzJ6M{[5
human COLO205 cells NGSz[|dRem:uaX\ldoF1cW:wIHHzd4F6 NHK5WodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPPUG8zODViY3XscJMh[nliTWTUJIF{e2G7IDygTWM2OD1{Mz61JO69VQ>? NUfTR2dlOjV2NUW0PFY>
mouse NIH/3T3 cells MUTDfZRwfG:6aXRCpIF{e2G7 NES4dZQ6PiCq MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NlQvOjJizszN NYXuOJFLOjJ5NEmzPVI>
human Caco-2 cells NXuycGZGS3m2b4TvfIlkyqCjc4PhfS=> NX62bZRWOyCmYYnz MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JHs{UF22aIntbYRqdmViaX7jc5Jxd3KjdHnvckBie3OjeR?= MUeyNFYzPzN5OR?=
human K562 cell line NVzxT|cyWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mke0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGxibHnu[UBmgHC{ZYPzbY5oKEKlcj3BZowtKEmFNUC9Nlgh|ryP M13VeFE3Pjh4NUSz
MCF7 cells MY\DfZRwfG:6aXRCpIF{e2G7 M3vuTlczKGh? NWHTRlhDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h\XO2cn;n[Y4hemWlZYD0c5IheG:|aYTpeoUhVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F697zOIFnDOVA:OjhwMEeg{txO NFvY[YczOzh4MEW5NC=>
mouse 3T3L1 cells MnX6SpVv[3Srb36gZZN{[Xl? MXG3JIRigXN? NG\VN45CdnSrYXTpdI9o\W6rYzDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKDOWM1yxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiZHnm[oVz\W62aXH0bY9vKGGodHXyJFch\GG7czDifUBwcWxvcnXkJG8he3SjaX7pcoctKEmFNUC9N|EvPCEQvF2= NIDZZlkyQTd3N{i1Ny=>
human HeLa cells MV;GeY5kfGmxbjDhd5NigQ>? NWTr[nJPOzBibXnudy=> NUnD[W4zUW6qaXLpeIlwdiCxZjDI[YRo\WixZzDzbYdv[WyrbnegdIF1cHejeTDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVG1CKGmwZIXj[YQhdHWlaX\ldoF{\SC2cnXheIVlKDNyIH3pcpMh[mWob4LlJIlv\HWldHnvci=> NFXURnIzOzV2N{i0Ny=>
human HT144 cells M{C2PHBzd2yrZnXyZZRqd25iYYPzZZk> NYTieGxFPSCmYYnz NIfENldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUNVQ1KGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDhZ4llKHCqb4PwbIF1[XOnIHHzd4F697zOIFnDOVA:PDBizszN MnnCNVk1QDF2NkK=
SKBR3 cells MnSzR5l1d3SxeHnjxsBie3OjeR?= M3PucFczKGh? MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDu[YdifGm4ZTDTT2JTOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H589yNKEmFNUC9OFEvPDJizszN MYKyN|g3ODV7MB?=
human MGC803 cells M1LnOnBzd2yrZnXyZZRqd25iYYPzZZk> NV;BVot[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTR{IN88US=> MlTKNlU1PTV2OE[=
human MDA468 cells NVjE[nBZWHKxbHnm[ZJifGmxbjDhd5NigQ>? MoS2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFG0Olgh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQ2NjJizszN MYOyOVQ2PTR6Nh?=
human HT-29 cells NGHO[Y9EgXSxdH;4bYPDqGG|c3H5 MnnrN{Bl[Xm| M2XmdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFMh\GG7czDifUBcO0ifdHj5cYllcW6nIHnuZ49zeG:{YYTpc44h[XO|YYmsJGlEPTB;NEWuN{DPxE1? MYOyNFYzPzN5OR?=
human SK-MEL cells Ml\MR5l1d3SxeHnjxsBie3OjeR?= M3y2U|Q5KGh? NFu3Z2ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUy2PRVygZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IGjUWEBie3Ojef-8kEBKSzVyPUS3MlMh|ryP Mn7WNlM2PDd6NEO=
human SH-SY5Y cells MYXGeY5kfGmxbjDhd5NigQ>? M1e5WW5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gTFJQOi2rbnT1Z4VlKHKnZIXjeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjdDCxNEB2VSCjZoTldkAzPCCqcoOgZpkheGijc3WtZ49vfHKjc4SgcYlkem:pcnHwbEBidmGueYPpdy=> MUKyOFI3QTVzNR?=
HUVEC NHmyb5JHfW6ldHnvckBie3OjeR?= MlrRNVAxKM7:TR?= MWexJIRigQ>? M4TtUmlv\HWldHnvckBw\iCvaYTvZ4hwdmS{aXHsJIJqd2enbnXzbZMhcW5iSELPNk1qdmS3Y3XkJGhWXkWFIHH0JFExOCC3bX;sM2wheHKndILlZZRm\CCob4KgNUBl[XliZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhUDKRMj30doVifG2nboSgcYVie3W{ZXSgZYZ1\XJiMUCg[IF6eyCkeTDNbZRwXHKjY3vldkBT\WRic4ThbY5qdmdvYnHz[YQh[XO|YYm= M{LWZlI{QDV7MkS5
human SW480 cells NEjnXm5EgXSxdH;4bYPDqGG|c3H5 M{mwe|ExKM7:TR?= NGPDToczKGSjeYO= MmDzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c1QDBiY3XscJMh[XRiMUCgeW0h\m:{IEKg[IF6eyCkeTD2bU1k\WyuIHPlcIwhfmmjYnnsbZR6KGGwYXz5d4l{ MUeyNVI6OTJ|NR?=
human LS 174T cells NYrJNpBKS3m2b4TvfIlkyqCjc4PhfS=> NXXqTVJjOTBizszN NF3mR241KGSjeYO= MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMV{AyPzSWIHPlcIx{KGG2IEGwJJVOKG[xcjC0JIRigXNiYomgeoku[2WubDDj[YxtKH[rYXLpcIl1gSCjbnHsfZNqew>? M3rJfFIyOjlzMkO1
human CCD-18Co cells NXTG[|h4TnWwY4Tpc44h[XO|YYm= NH\pfZYyKM7:TR?= MknLNVghcA>? MWLBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFPDSE0yQEOxIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[gTWwy[mW2YT3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiCjdDCxJJVOKGGodHXyJFE5KGi{cx?= M1fF[VIxQDZ4MEOy
mouse C2C12 cells NUHFbI9bTnWwY4Tpc44h[XO|YYm= Mlu5OVAh|ryP MXyxOkBp M17YV2lv[3KnYYPlJIlvKG2rdH;jbI9v\HKrYXyg[pVv[3Srb36gbY4hdW:3c3WgR|JEOTJiY3XscJMh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgc4YhdWm2b3Poc45lemmjbDDk[Y5{cXS7IHH0JFUxKHWPIHHmeIVzKDF4IHjyd{BjgSCpcnXlckBHVSCmeXWgd5Rz[WmwaX7nMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeR?= NHXGN4syQTZ4M{S5PC=>
human H460 cells M2q3W2Z2dmO2aX;uJIF{e2G7 MkG4NlAh|ryP MXOyOEBp MoDUR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzJxTTDwbIF{\SCjdDCyNEB2VSCjZoTldkAzPCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcI94KGO7dH;t[ZRzgQ>? NHLrUYwzODRyOUeyNy=>
mouse MC3T3-E1 cells M4q4[2Fxd3C2b4Ppd{Bie3OjeR?= NYHVdmpGOSEQvF2= NVHUeZR7PDhiaB?= MmHnTY5pcWKrdHnvckBw\iCjboTpZZBweHSxdHnjJIFkfGm4aYT5JIlvKG2xdYPlJG1EO1R|LVWxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIlvKHC{ZYPlcoNmKG:oIFLNVFIue3CnY3nmbYMhdmW3dILhcIl7cW6pIHHueIljd2S7 NYP1U5VPOTd3MUO4Olc>
human THP1 cells Ml7FSpVv[3Srb36gZZN{[Xl? NFfl[|EyODBizszN MmX6NUBp MVXJcohq[mm2aX;uJI9nKE[VTEGtbY5lfWOnZDD1dJJm\3WuYYTpc44hd2ZiZHXjeIlvNTFibWLORUBmgHC{ZYPzbY9vKGmwIHnuJIh2dWGwIGTIVFEh[2WubIOgZZQhOTByIIXNJIFnfGW{IEGgbJIh[nliUmStVGNT NHPJTlYyPzl|OEG4Oy=>
human T47D cells MkHQVJJwdGmoZYLheIlwdiCjc4PhfS=> M3LQZ|Eh|ryP Mnq1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWNEfEJINmdGy|IHH0JFEhfU1iYomg[oxwfyCleYTvcYV1enl? M4TYPFE4PTF|OE[3
human MG63 cells Mn\4SpVv[3Srb36gZZN{[Xl? MmnwNE4yKHSxIEGwJJVO MUO3JIRigXN? M13oVGlv[3KnYYPlJIlvKEGOUDDhZ5Rqfmm2eTDpckBpfW2jbjDNS|Y{KGOnbHzzJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB5IHThfZM> NWTifXFEOTd3MUO4Olc>
human U2OS cells MlXkSpVv[3Srb36gZZN{[Xl? MWOxNFAh|ryP NEXzUlZC[3SrdnH0bY9vKG:oIGPJVnQyKGmwIHj1cYFvKFV{T2OgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heDV|IHTlZYNmfHmuYYTpc44hdGW4ZXygZZQhOTByIIXN Mn\jNVgxPDZ2MEm=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Nanog / Oct-4 / Sox-2 ; 

PubMed: 21304978     


Pancreatic CSCs were treated with resveratrol (0–30 µM) for 48 h. The expression of Nanog, Oct-4 and Sox-2 was measured by the Western blot analysis. GAPDH was used as a loading control. 

p-EGFR / EGFR / p-HER2 / HER2 / p-ERK / ERK / PTEN ; 

PubMed: 20729295     


DU145 cells were treated with DMSO, and 10, 20 or 50 µm resveratrol. Western blots show resveratrol decreased phosphorylation of EGFR-Tyr1068 (upper panel), HER2-Tyr1221/1222 (second panel).

21304978 20729295
Growth inhibition assay
Cell viability; 

PubMed: 23272133     


A, MTS assay was performed on PC-3M-MM2 cells treated with vehicle or different concentrations of resveratrol (5–100 µM) for 72 h which showed that resveratrol dose-dependently reduced cell viability. B, Decrease in cell viability by resveratrol was time-dependent in the resveratrol-treated groups (25 and 50 µM) compared to vehicle.

23272133
In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

- Collapse
  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

- Collapse
  • Animal Models: Human ovarian xenografts PA-1
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03743636 Recruiting Drug: Nicotinamide riboside|Drug: Resveratrol|Other: Placebo Peripheral Artery Disease Northwestern University|American Heart Association October 1 2018 Phase 3
NCT03253913 Unknown status Drug: Sirolimus|Drug: Resveratrol Lymphangioleiomyomatosis University of Cincinnati|National Heart Lung and Blood Institute (NHLBI) March 31 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Autophagy Signaling Pathway Map

Tags: buy Resveratrol | Resveratrol ic50 | Resveratrol price | Resveratrol cost | Resveratrol solubility dmso | Resveratrol purchase | Resveratrol manufacturer | Resveratrol research buy | Resveratrol order | Resveratrol mouse | Resveratrol chemical structure | Resveratrol mw | Resveratrol molecular weight | Resveratrol datasheet | Resveratrol supplier | Resveratrol in vitro | Resveratrol cell line | Resveratrol concentration | Resveratrol nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID