Resveratrol

Catalog No.S1396

Resveratrol Chemical Structure

Molecular Weight(MW): 228.24

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 310 In stock
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  • PC-9 and A549 cells were treated with 100 nM siRNA against PUMA and 100 nM negative control (NC) siRNA for 12 h, and treated with the indicated concentrations of RV and ERL in combination for an additional 48 h. The knockdown effects on PUMA were confirmed by Western blot analysis.

    Cell Physiol Biochem, 2015, 35: 2255-2271 . Resveratrol purchased from Selleck.

    Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.

    Dr. Johanna Weiss of University Hospital Heidelberg. Resveratrol purchased from Selleck.

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells NE\0XJNRem:uaX\ldoF1cW:wIHHzd4F6 M3O3SlQ5KGh? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjJ3ZT2wOUDPxE1? M1PQbFIyQDVzMEiz
human SK-N-SH cells M{f6ZnBzd2yrZnXyZZRqd25iYYPzZZk> MUi0PEBp NH;XU4xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW4uW0hiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlA{\S1yNR?= NFeyXY8zOTh3MUC4Ny=>
human A549 cells NUTheZBUWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1S2[VQ5KGh? MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF01NjR5ZT2wOS=> MVqyNVg2OTB6Mx?=
human MCF7 cells NGXWW49Rem:uaX\ldoF1cW:wIHHzd4F6 Mn3COFghcA>? NFHpeZhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD15Lkmx[U0xPQ>? MnLrNlE5PTFyOEO=
HEK293 cells Mo\ESpVv[3Srb36gZZN{[Xl? NID6bVE1QCCq M1iwSGlvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3cXS7IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkG3N{DPxE1? NYDTOnh1OjB3Mke4PVE>
RAW264.7 cells M322fGZ2dmO2aX;uJIF{e2G7 NEG2cJpKdmirYnn0c5J6KGWoZnXjeEBwdiCSR1WtNkBxem:mdXP0bY9vKGmwIFzQV{1{fGmvdXzheIVlKFKDV{K2OE44KGOnbHzzMEBKSzVyPUSg{txO NWfKTVZEOTVyOEC5PFg>
mouse HT22 cells NIC4dWhHfW6ldHnvckBie3OjeR?= MkLUNlQhcA>? MXrO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3i7dH;zbZMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> M3PTVVIyOTJ7OUe4
human HL60 cell line NWD0SlRMWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mmi0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGxibHnu[UwhUUN3ME21JO69VQ>? M1vVelE3Pjh4NUSz
human Huh7.5.1 cells M1TGTWN6fG:2b4jpZ:Kh[XO|YYm= NWr0VIJkPzJiaB?= MnL4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpPy53LkGgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGwMlYh|ryP MkHHNlM3PzN{MkW=
mouse Hepa1clc7 cells Mn;YR5l1d3SxeHnjxsBie3OjeR?= MVK3NkBp MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDI[ZBiOWOuY{egZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUGxJO69VQ>? MnzVNVAxPzV5NEK=
human H460 cells MkK0VJJwdGmoZYLheIlwdiCjc4PhfS=> NIfLWVc4OiCq MlrFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKNE[wJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2xNk46KM7:TR?= NWWxfmFtOjB2MEm3NlM>
human 293 cells NFrTWZpHfW6ldHnvckBie3OjeR?= NH7PcokzPCCq MVfJcohq[mm2aX;uJI9nKFSQRnHsdIhiKGmwZIXj[YQhVkZva3HwdIFDKGGldHn2ZZRqd25iaX6gbJVu[W5iMkmzJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MU[uNUDPxE1? MWixPFQ5PzB3Mx?=
human U937 cells NWq1SlhES3m2b4TvfIlkyqCjc4PhfS=> Mn20OFghcA>? MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDXV3QyKHSnc4SsJGlEPTB;MUeg{txO NHzIfWkyPjJ3MkmyOC=>
human MCF7 cells NWDZZZBTTnWwY4Tpc44h[XO|YYm= MlrXOkBp M4XCZWlvcGmkaYTpc44hd2ZicHjvdoJwdCCnc4Tldk1qdmS3Y3XkJI9zdmm2aHnu[UBl\WOjcnLvfJlt[XOnIHnuJIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNjDodpMtKEmFNUC9NVkh|ryP NVi2WGFlOTByN{W3OFI>
HEK293T cells NYKw[HFZTnWwY4Tpc44h[XO|YYm= M2DtbGlvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hUEWNMkmzWEBk\WyuczygTWM2OD1{MDFOwG0> NFjRWnMyPzF{NUK3NC=>
human SW480 cells MoXDVJJwdGmoZYLheIlwdiCjc4PhfS=> M{PWN|Q5KGh? Mlv2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4NEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTD1d4lv\yCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oKGGodHXyJFQ5KGi{czygTWM2OD1{MDFOwG0> MYqyNFM6PTBzOR?=
human MDA-MB-231 cells MWDGeY5kfGmxbjDhd5NigQ>? M3LF[lYh\GG7cx?= M4\6[2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KFOUQjDhd5NigSxiSVO1NF0zOC53IN88US=> MkDBNlA4Ojh|Nkm=
human COLO205 cells MXTQdo9tcW[ncnH0bY9vKGG|c3H5 M1Hv[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1;MU|IxPSClZXzsd{BjgSCPVGSgZZN{[XliLDDJR|UxRTJ|LkWg{txO NWnoS4hQOjV2NUW0PFY>
mouse NIH/3T3 cells Moj4R5l1d3SxeHnjxsBie3OjeR?= MXq5OkBp MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NlQvOjJizszN MkPrNlI4PDl|OUK=
human Caco-2 cells MkHsR5l1d3SxeHnjxsBie3OjeR?= MV2zJIRigXN? MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JHs{UF22aIntbYRqdmViaX7jc5Jxd3KjdHnvckBie3OjeR?= NV;DboJFOjB4MkezO|k>
human K562 cell line NXrUVHlTWHKxbHnm[ZJifGmxbjDhd5NigQ>? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdCCuaX7lJIV5eHKnc4PpcochSmO{LVHicEwhUUN3ME2yPEDPxE1? NXHFOGJbOTZ4OE[1OFM>
MCF7 cells MlTVR5l1d3SxeHnjxsBie3OjeR?= NWHy[3RMPzJiaB?= M3fWN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJJBwe2m2aY\lJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4Phfg+9lCCLQ{WwQVI5NjB5IN88US=> NXGyWIp{OjN6NkC1PVA>
mouse 3T3L1 cells MkHBSpVv[3Srb36gZZN{[Xl? MVK3JIRigXN? NGDHXGFCdnSrYXTpdI9o\W6rYzDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKDOWM1yxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiZHnm[oVz\W62aXH0bY9vKGGodHXyJFch\GG7czDifUBwcWxvcnXkJG8he3SjaX7pcoctKEmFNUC9N|EvPCEQvF2= NF\HOpUyQTd3N{i1Ny=>
human HeLa cells NIPVZpVHfW6ldHnvckBie3OjeR?= NIrlNYY{OCCvaX7z MojxTY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdicHH0bJdigSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiUF3BJIlv\HWlZXSgcJVkcW[ncnHz[UB1emWjdHXkJFMxKG2rboOgZoVnd3KnIHnu[JVkfGmxbh?= MWSyN|U1Pzh2Mx?=
human HT144 cells MYfQdo9tcW[ncnH0bY9vKGG|c3H5 MmTSOUBl[Xm| NInXcWdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUNVQ1KGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDhZ4llKHCqb4PwbIF1[XOnIHHzd4F697zOIFnDOVA:PDBizszN NFjQfYcyQTR6MUS2Ni=>
SKBR3 cells MVfDfZRwfG:6aXRCpIF{e2G7 MkPyO|IhcA>? NYLZbIZsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h\XO2cn;n[Y4hemWlZYD0c5IhdmWpYYTpeoUhW0uEUkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5Nige,:jDDJR|UxRTRzLkSyJO69VQ>? M33EXlI{QDZyNUmw
human MGC803 cells MYDQdo9tcW[ncnH0bY9vKGG|c3H5 M{XscmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF01OiEQvF2= MnXvNlU1PTV2OE[=
human MDA468 cells MlG2VJJwdGmoZYLheIlwdiCjc4PhfS=> NVjhdGRkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGE1PjhiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTR3LkKg{txO NY\WcGpiOjV2NUW0PFY>
human HT-29 cells MmLJR5l1d3SxeHnjxsBie3OjeR?= NYfsfoU{OyCmYYnz M2PsTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFMh\GG7czDifUBcO0ifdHj5cYllcW6nIHnuZ49zeG:{YYTpc44h[XO|YYmsJGlEPTB;NEWuN{DPxE1? Mk\ENlA3Ojd|N{m=
human SK-MEL cells NVn5WFJwS3m2b4TvfIlkyqCjc4PhfS=> NGWzW|k1QCCq MmfpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XoxvJygTWM2OD12Nz6zJO69VQ>? NGi2OVkzOzV2N{i0Ny=>
human SH-SY5Y cells M1jBTGZ2dmO2aX;uJIF{e2G7 NHS4OXVP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hcHWvYX6gV2guW1l3WTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJGgzVzJvaX7keYNm\CC{ZXT1Z5Rqd25ib3[gZ4VtdCC4aXHibYxqfHliYYSgNVAhfU1iYX\0[ZIhOjRiaILzJIJ6KHCqYYPlMYNwdnS{YYP0JI1q[3KxZ4LhdIgh[W6jbInzbZM> M1\Xc|I1OjZ7NUG1
HUVEC M4TZcGZ2dmO2aX;uJIF{e2G7 M{jYUFExOCEQvF2= MlfjNUBl[Xl? MnXzTY5lfWO2aX;uJI9nKG2rdH;jbI9v\HKrYXygZolw\2WwZYPpd{BqdiCKMl:yMYlv\HWlZXSgTHVXTUNiYYSgNVAxKHWvb3yvUEBxemW2cnXheIVlKG[xcjCxJIRigSCob3zsc5dm\CCkeTDjc41xd3WwZDD3ZZNpd3W2IHHu[EBJOk9{LYTy[YF1dWWwdDDt[YF{fXKnZDDh[pRmeiBzMDDkZZl{KGK7IF3peI9VemGla3XyJHJm\CC|dHHpcolv\y2kYYPl[EBie3OjeR?= M2f1TVI{QDV7MkS5
human SW480 cells MkjaR5l1d3SxeHnjxsBie3OjeR?= NYnBTG9nOTBizszN NIWzfIczKGSjeYO= M3;CdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYPDhyIHPlcIx{KGG2IEGwJJVOKG[xcjCyJIRigXNiYomgeoku[2WubDDj[YxtKH[rYXLpcIl1gSCjbnHsfZNqew>? NXP0VIxZOjF{OUGyN|U>
human LS 174T cells NX7lSo1vS3m2b4TvfIlkyqCjc4PhfS=> Mnj6NVAh|ryP NWrHNINIPCCmYYnz MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMV{AyPzSWIHPlcIx{KGG2IEGwJJVOKG[xcjC0JIRigXNiYomgeoku[2WubDDj[YxtKH[rYXLpcIl1gSCjbnHsfZNqew>? NICwWmczOTJ7MUKzOS=>
human CCD-18Co cells NVf2VIJOTnWwY4Tpc44h[XO|YYm= MXqxJO69VQ>? NWnsTI9iOThiaB?= Moj2RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDDR2QuOTiFbzDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJGlNOWKndHGtbY5lfWOnZDDQS2UzKHC{b3T1Z5Rqd25iYYSgNUB2VSCjZoTldkAyQCCqcoO= M4K1cFIxQDZ4MEOy
mouse C2C12 cells NF;MfW9HfW6ldHnvckBie3OjeR?= Mmf6OVAh|ryP Mk\DNVYhcA>? NHjqU5lKdmO{ZXHz[UBqdiCvaYTvZ4hwdmS{aXHsJIZ2dmO2aX;uJIlvKG2xdYPlJGMzSzF{IHPlcIx{KGG|c3Xzd4VlKGG|IHXubIFv[2WvZX70JI9nKG2rdH;jbI9v\HKrYXyg[IVve2m2eTDheEA2OCC3TTDh[pRmeiBzNjDodpMh[nliZ4Ll[Y4hTk1iZInlJJN1emGrbnnu[{1j[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYm= MVixPVY3OzR7OB?=
human H460 cells NF\qPZNHfW6ldHnvckBie3OjeR?= MX[yNEDPxE1? MlrzNlQhcA>? NVrZN2Y4S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hUDR4MDDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{KvUUBxcGG|ZTDheEAzOCC3TTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{eR?= MnjTNlA1ODl5MkO=
mouse MC3T3-E1 cells MUHBdI9xfG:|aYOgZZN{[Xl? NWPuOoYxOSEQvF2= NWi3WWVUPDhiaB?= MmWxTY5pcWKrdHnvckBw\iCjboTpZZBweHSxdHnjJIFkfGm4aYT5JIlvKG2xdYPlJG1EO1R|LVWxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIlvKHC{ZYPlcoNmKG:oIFLNVFIue3CnY3nmbYMhdmW3dILhcIl7cW6pIHHueIljd2S7 MkTHNVc2OTN6Nke=
human THP1 cells M1HxUGZ2dmO2aX;uJIF{e2G7 NHPRelAyODBizszN NV61Tnp2OSCq Mn2zTY5pcWKrdHnvckBw\iCIU1yxMYlv\HWlZXSgeZBz\We3bHH0bY9vKG:oIHTlZ5Rqdi1zIH3SUmEh\XiycnXzd4lwdiCrbjDpckBpfW2jbjDUTHAyKGOnbHzzJIF1KDFyMDD1UUBi\nSncjCxJIhzKGK7IGLUMXBEWg>? M{\Ke|E4QTN6MUi3
human T47D cells M1OwW3Bzd2yrZnXyZZRqd25iYYPzZZk> NUXjSXF2OSEQvF2= Mlj0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWNEfEJINmdGy|IHH0JFEhfU1iYomg[oxwfyCleYTvcYV1enl? M2DpZlE4PTF|OE[3
human MG63 cells NXr2Ro9ITnWwY4Tpc44h[XO|YYm= MWGwMlEhfG9iMUCgeW0> MoHOO{Bl[Xm| NEe5fGJKdmO{ZXHz[UBqdiCDTGCgZYN1cX[rdImgbY4hcHWvYX6gUWc3OyClZXzsd{BifCByLkGgeI8hOTBidV2gZYZ1\XJiNzDkZZl{ MVqxO|UyOzh4Nx?=
human U2OS cells NXfBPFdjTnWwY4Tpc44h[XO|YYm= M{\hOFExOCEQvF2= NFLFNoVC[3SrdnH0bY9vKG:oIGPJVnQyKGmwIHj1cYFvKFV{T2OgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heDV|IHTlZYNmfHmuYYTpc44hdGW4ZXygZZQhOTByIIXN MUWxPFA1PjRyOR?=

... Click to View More Cell Line Experimental Data

In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Human ovarian xenografts PA-1
  • Formulation: Solution in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02905799 Recruiting Knee Osteoarthritis Assistance Publique - Hôpitaux de Paris|Unité de Recherche Clinique (URC) Paris Descartes Cochin November 9 2017 Phase 3
NCT01842399 Recruiting Vascular Resistance|Aging|Hypertension|Antioxidants|Aerobic Capacity National Institute on Aging (NIA)|National Institutes of Health Clinical Center (CC) February 9 2013 Phase 1|Phase 2
NCT03541993 Completed Hypoxia Altitude|Brain Northumbria University June 7 2016 Not Applicable
NCT03546075 Completed Cognitive Change Northumbria University May 7 2015 Not Applicable
NCT03448094 Recruiting Cognitive Function and Mood|Cerebral Blood Flow|Systemic Inflammation|Gut Microbiota|Overweight and Obesity Northumbria University|Evolva SA February 6 2018 Not Applicable
NCT03349619 Recruiting Allergic Rhinitis Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy March 5 2018 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID