Nocodazole (R17934)

Catalog No.S2775 Synonyms: Oncodazole, NSC238159

For research use only.

Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.

Nocodazole (R17934) Chemical Structure

CAS No. 31430-18-9

Selleck's Nocodazole (R17934) has been cited by 86 publications

Purity & Quality Control

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Biological Activity

Description Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Targets
Microtubules [2]
(Cell-free assay)
Abl [1]
(Cell-free assay)
Abl (E255K) [1]
(Cell-free assay)
Abl (T315I) [1]
(Cell-free assay)
0.21 μM 0.53 μM 0.64 μM
In vitro

Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 μM, 1.6 μM, 1.8 μM and 1.6 μM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3Kγ is 0.12 μM, 0.17 μM, 1.1 μM and 1.5 μM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells. [1] At high concentrations, Nocodazole rapidly depolymerizes microtubules in cells, while low concentrations of Nocodazole inhibit microtubule dynamic instability. [2] Mitotic cells incubated with different concentrations of Paclitaxel are inhibited from progressing to G1 phase 6 hours after release from the Nocodazole block, with a median inhibitory concentration of 4 nM. Nocodazole-pretreated cells exposed to Paclitaxel in the absence of Nocodazole only form free-floating microtubules, whereas pretreated cells exposed to Paclitaxel in the presence of Nocodazole-assembled centrosome organize microtubules. [3] Nocodazole disrupts microtubules by binding to β-tubulin. Nocodazole prevents the formation of one of the two interchain disulfide linkages. Nocodazole impairs the transport of vesicles. Nocodazole suppress METH-induced cell death and lysosomal dysfunction. METH-induced cell death is significantly decreased by Nocodazole pretreatment in comparison to METH alone. [4]Nocodazole doubles HDR efficiency to up to 30% in iPSCs. It improves the CRISPR-mediated HDR efficiency and has an additive effect on enhancing precise genome editing[6].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 murine leukemia cell MkHkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoT6TY4hfmm2cn:g[o9zKGm2czDpcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgUFEzOTBibYXybY5mKGyndXvlcYliKGOnbHyg[5Jwf3SqLDDJR|UxRTN6IH7N NX2xfpF4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezPFE1Pid-MUezPFE1PjxxYU6=
LT12 NV;5OmFvSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmfHOFghcHK| M33rc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgdoF1KEyWMUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEC2JO69VS5? NV[1XnJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
HepG2 MnHOSpVv[3Srb36gZZN{[Xl? M4PXR|AvOSC2bzCxNEB2VQ>? MVixJIhz NHG1Z5BKdmirYnn0bY9vKG:oIGTOSoFteGijLXnu[JVk\WRiTl\rZZBx[UJiKIXub45wf25ib4Lp[4lvMS2mZYDlcoRmdnRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDheEAxNjFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAyKGi{IIDybY9zKHSxIGTOSoFteGijIHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCmdXHsMYx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NEDFT|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyO|UzOid-MkW4Nlc2OjJ:L3G+
PANC1 Mle3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NVnnXmJmPDhiaILz NGfnfFNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAyKM7:TT6= M2XncFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
HeLa MnXQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVe0PEBpenN? Mmn1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxJO69VS5? M3XjbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
MDA-MB-231 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnPqOFghcHK| MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODFizszNMi=> M1LpO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
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MDA-MB-231 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXi0PEBpenN? MnjhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjBzNzFOwG0v MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{N{WyNkc,OjV6Mke1NlI9N2F-
A549 NIj3TYpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUHUOoR7PDhiaILz M2OySGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNkDPxE1w M3vhblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
L1210 MlHBSpVv[3Srb36gZZN{[Xl? NFvjSJQ1QCCqcoO= NInaRoZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDwdo9tcW[ncnH0bY9vKG:oIHP1cJR2emWmIHz5cZBpd2mmIHzleYtmdWmjIFyxNlExKGOnbHzzJIR2emmwZzC0PEBpenNuIFnEOVAhRSByLkCyO{DPxE1w NFGzXJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MUOxOFg{Lz55MUOxOFg{RC:jPh?=
PANC1 MVrBcpRq[2GwY3XyJIF{e2G7 NXvpc5EyPDhiaILz NFntTlFCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODJ7IN88UU4> MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{CzOVcoRjJ5MUOwN|U4RC:jPh?=
A549 NGrT[YhEgXSxdH;4bYNqfHliYYPzZZk> M3zqcFI1KGi{cx?= NEXrbItEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB|Nk[g{txONg>? NYHzUXVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVAyOzdpPkKwNVExOTN5PD;hQi=>
NCI60 Ml7yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{TVb|Q5KGi{cx?= NUjleHdnT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLNkCgZ4VtdHNiaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IECuNFM5QSEQvF2u M1TGUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUW2NFM5Lz5{N{m1OlA{QDxxYU6=
P388 NGj4d3RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3TPdFQ5KGi{cx?= NULlUoR3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDQN|g5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO|YYmsJGlEPTBiPTCwMlA1KM7:TT6= NGfZ[lU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
LT12 NFnSOFFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXO0PEBpenN? MkfkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDMWFEzKGOnbHzzJIJ6KFiWVDDhd5NigSCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlA1KM7:TT6= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
LT12 M2DnVGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGn5NnQ1QCCqcoO= NIDUb3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJJifCCOVEGyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkC0JO69VS5? M4rLb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUO3O|Y2Lz5{MEWzO|c3PTxxYU6=
LT12 MoHkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NU\1T4M1PDhiaILz MlTURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDyZZQhVFRzMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOC5yNDFOwG0v MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyNUKyN{c,OjF5MEWyNlM9N2F-
MDA-MB-231 NGTHSpBCdnSrY3HuZ4VzKGG|c3H5 NIfWeIM1QCCqcoO= Moq3RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMESyJO69VS5? MlLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{CzOVcoRjJ5MUOwN|U4RC:jPh?=
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P388 MYPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWG0PEBpenN? MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKGGmcnnhcZlkcW5vcnXzbZN1[W62IGCzPFgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuNFUh|ryPLh?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
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L1210 NHXSbVJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NX\LSpdMPDhiaILz M2L5V2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTEGyNVAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuNFUh|ryPLh?= NFLITnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEWzO|c3PSd-MkC1N|c4PjV:L3G+
P388 MmHCRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmPaOFghcHK| NY[2XnpFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBCTFJvcnXzbZN1[W62IH3veZNmKFB|OEigZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEWg{txONg>? MmfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEWyNlMoRjJzN{C1NlI{RC:jPh?=
U2OS NHrVUolHfW6ldHnvckBie3OjeR?= M3e5SlczKGi{cx?= M1frbGlv\HWldHnvckBw\iCvaYTveIlkKGG{cnXzeEBqdiCqdX3hckBWOk:VIHPlcIx{KGG|c3Xzd4VlKGG|IH3peI91cWNiaX7k[Zgh[W[2ZYKgO|IhcHK|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwJF0hOC5yNTFOwG0v M2PjOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwPFg4Lz5{NEmwNFg5PzxxYU6=
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BT-12 MXLxTHRUKGG|c3H5 MYjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDCWE0yOiClZXzsdy=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
LAN-5 M3;tTZFJXFNiYYPzZZk> MXTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDMRW4uPSClZXzsdy=> MkfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
DAOY NV\l[nZDeUiWUzDhd5NigQ>? NELvTI1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBFSU:\IHPlcIx{ NVTFdoY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-37 M3;rT5FJXFNiYYPzZZk> M3fJ[JFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{ MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
TC32 MmLIdWhVWyCjc4PhfS=> NVzEcmhIeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? Mkj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
MG 63 (6-TG R) MnfhdWhVWyCjc4PhfS=> M1fJN5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG1IKDZ|IDi2MXRIKFJrIHPlcIx{ NIrFdpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
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Saos-2 M4rPdZFJXFNiYYPzZZk> Ml[xdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV4Fwey1{IHPlcIx{ MkLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 NFW3SZFyUFSVIHHzd4F6 Mo[0dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgU2hUNTVyIHPlcIx{ NXjvSIJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
HeLa NVPqPWdDTnWwY4Tpc44h[XO|YYm= NXjoNINUOjRiaILz NHTu[pBKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB{d2y3YnzlJJR2[nWuaX6g[pJi[3Srb36gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NI\yR|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEixPFc3QCd-Mki4NVg4Pjh:L3G+
HeLa M{TXOWZ2dmO2aX;uJIF{e2G7 NH\0VHAxNjFidV2= MYiyOEBpenN? M1Tzc2lvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvckBqdiCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IIPobYZ1KG:oIIT1ZpVtcW5icILveIVqdiC2bzDzc4x2[mynIH\yZYN1cW:wIHH0JFAvOSC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz Mo\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MEG5OFAoRjJ7NUCxPVQxRC:jPh?=
PC3MLN4 MXPGeY5kfGmxbjDhd5NigQ>? M2nhT|EhfU1? NWTiSGQ4OjRiaILz NWnTfpdFXXC{ZXf1cIF1cW:wIH;mJGN6[2yrbj3CNUBxem:2ZXnuJIV5eHKnc4Ppc44hcW5iaIXtZY4hWEN|TVzOOEBk\WyuczDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEmzPUc,Ojl{OEi5N|k9N2F-
PC3MLN4 NHezd3hHfW6ldHnvckBie3OjeR?= M4nW[FEhfU1? MWW0PEBpenN? NELuRoNFcXO{dYD0bY9vKG:oIH3pZ5JwfHWkdXzlJIR6dmGvaXPzJIlvKGi3bXHuJHBEO02OTkSgZ4VtdHNiYYSgNUB2VSCjZoTldkA1QCCqcoOgZpkhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweGmlIH3leIhw\A>? M4Pac|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVM6Lz5{OUK4PFk{QTxxYU6=
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Assay
Methods Test Index PMID
Western blot Cdc2 / cyclin B1 / MAD2 / Cdc20 21918689
Immunofluorescence Brd4 / α-tubulin ; Tubulin / LC8 22567088 23038268
Growth inhibition assay Cell viability 21918689
In vivo The tumor volume and tumor weight of the mice treated with Ketoconazole  plus  Nocodazole are significantly reduced as compared with those treated with Ketoconazole or Nocodazole alone. Combined treatment with Ketoconazole  plus  Nocodazole strongly enhances apoptosis of COLO 205 tumor xenografts treated with Ketoconazole  or  Nocodazole alone. [5]

Protocol (from reference)

Animal Research:

[5]

  • Animal Models: Nude mice with COLO-205 tumor xenografts
  • Dosages: 5 mg/kg
  • Administration: Administered via i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

1mg/mL

Chemical Information

Molecular Weight 301.32
Formula

C14H11N3O3S

CAS No. 31430-18-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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