Nocodazole (R17934)

Catalog No.S2775 Synonyms: Oncodazole, NSC238159

For research use only.

Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.

Nocodazole (R17934) Chemical Structure

CAS No. 31430-18-9

Selleck's Nocodazole (R17934) has been cited by 80 publications

Purity & Quality Control

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Biological Activity

Description Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Targets
Microtubules [2]
(Cell-free assay)
Abl [1]
(Cell-free assay)
Abl (E255K) [1]
(Cell-free assay)
Abl (T315I) [1]
(Cell-free assay)
0.21 μM 0.53 μM 0.64 μM
In vitro

Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 μM, 1.6 μM, 1.8 μM and 1.6 μM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3Kγ is 0.12 μM, 0.17 μM, 1.1 μM and 1.5 μM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells. [1] At high concentrations, Nocodazole rapidly depolymerizes microtubules in cells, while low concentrations of Nocodazole inhibit microtubule dynamic instability. [2] Mitotic cells incubated with different concentrations of Paclitaxel are inhibited from progressing to G1 phase 6 hours after release from the Nocodazole block, with a median inhibitory concentration of 4 nM. Nocodazole-pretreated cells exposed to Paclitaxel in the absence of Nocodazole only form free-floating microtubules, whereas pretreated cells exposed to Paclitaxel in the presence of Nocodazole-assembled centrosome organize microtubules. [3] Nocodazole disrupts microtubules by binding to β-tubulin. Nocodazole prevents the formation of one of the two interchain disulfide linkages. Nocodazole impairs the transport of vesicles. Nocodazole suppress METH-induced cell death and lysosomal dysfunction. METH-induced cell death is significantly decreased by Nocodazole pretreatment in comparison to METH alone. [4]Nocodazole doubles HDR efficiency to up to 30% in iPSCs. It improves the CRISPR-mediated HDR efficiency and has an additive effect on enhancing precise genome editing[6].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 murine leukemia cell NUDJZno2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfjOVQ4UW5idnn0do8h\m:{IHn0d{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhVDF{MUCgcZVzcW6nIHzleYtmdWmjIHPlcIwh\3Kxd4ToMEBKSzVyPUO4JI5O NUTyR|JERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezPFE1Pid-MUezPFE1PjxxYU6=
LT12 M2\wSGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEDlPIE1QCCqcoO= M4m1RmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgdoF1KEyWMUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEC2JO69VS5? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
HepG2 NHjaeGFHfW6ldHnvckBie3OjeR?= NV\KT5RTOC5zIITvJFExKHWP M4D5WlEhcHJ? NHHYdo1KdmirYnn0bY9vKG:oIGTOSoFteGijLXnu[JVk\WRiTl\rZZBx[UJiKIXub45wf25ib4Lp[4lvMS2mZYDlcoRmdnRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDheEAxNjFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAyKGi{IIDybY9zKHSxIGTOSoFteGijIHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCmdXHsMYx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NGrDW|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyO|UzOid-MkW4Nlc2OjJ:L3G+
PANC1 M1eyRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHHjVHE1QCCqcoO= NELvOlVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAyKM7:TT6= Ml7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OEixPVMoRjJ5Nki4NVk{RC:jPh?=
HeLa M3;BVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHHBRmU1QCCqcoO= MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEGg{txONg>? NYX1fXkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQTNpPkK3Olg5OTl|PD;hQi=>
MDA-MB-231 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVT4[lFuPDhiaILz MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODFizszNMi=> NYH4bWo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFgyQTNpPkK3Olg5OTl|PD;hQi=>
A549 M2f0bmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGTYXG01QCCqcoO= NYrpcZY2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[2WubDDwdo9tcW[ncnH0bY9vKGG|c3H5MEBIUTVyIE2gNE4xOSEQvF2u M1vHV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi5NlM{Lz5{OUC4PVI{OzxxYU6=
HeLa M{TtT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUi0PEBpenN? MmPZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZ4VtdCCycn;sbYZmemG2aX;uJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w NHrDZow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4PVI{Oyd-MkmwPFkzOzN:L3G+
MDA-MB-231 MnG4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3zyfVQ5KGi{cx?= Mlq5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiY3XscEBxem:uaX\ldoF1cW:wIHHzd4F6NCCJSUWwJF0hOC5yMTFOwG0v MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6OUKzN{c,OjlyOEmyN|M9N2F-
HeLa NFHjXo5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2P4fFQ5KGi{cx?= NVv0V2gzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAyPSEQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{N{WyNkc,OjV6Mke1NlI9N2F-
MDA-MB-231 NWfFRlF4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXXs[JhCPDhiaILz NHjQUZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEG3JO69VS5? Mn7WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6Mke1NlIoRjJ3OEK3OVIzRC:jPh?=
A549 M2PJb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXKyRlBsPDhiaILz M3PNfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNkDPxE1w M3fhRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
L1210 NHzFSmpHfW6ldHnvckBie3OjeR?= MXi0PEBpenN? MV;Jcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCycn;sbYZmemG2aX;uJI9nKGO3bIT1doVlKGy7bYDoc4llKGyndXvlcYliKExzMkGwJINmdGy|IHT1dolv\yB2ODDodpMtKEmGNUCgQUAxNjB{NzFOwG0v NFH4fnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MUOxOFg{Lz55MUOxOFg{RC:jPh?=
PANC1 NFHOZnFCdnSrY3HuZ4VzKGG|c3H5 MUG0PEBpenN? MnzzRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAzQSEQvF2u MkHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{CzOVcoRjJ5MUOwN|U4RC:jPh?=
A549 MYfDfZRwfG:6aXPpeJkh[XO|YYm= NYL2SJF5OjRiaILz M4XBb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODN4NjFOwG0v Mn7CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUCxN|coRjJyMUGwNVM4RC:jPh?=
NCI60 NWPN[|VJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIHCfXU1QCCqcoO= MmrIS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKPjBiY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDBwMEO4PUDPxE1w NGO3WZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlA{QCd-Mke5OVYxOzh:L3G+
P388 NYW5S2xnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkfSOFghcHK| NWHORoFFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDQN|g5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO|YYmsJGlEPTBiPTCwMlA1KM7:TT6= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
LT12 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVrqUVdoPDhiaILz MnX6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDMWFEzKGOnbHzzJIJ6KFiWVDDhd5NigSCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlA1KM7:TT6= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
LT12 NWjPZldXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmT2OFghcHK| MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IILheEBNXDF{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBZXFRiYYPzZZktKEmFNUCgQUAxNjB2IN88UU4> NXf5Z5pURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1N|c4PjVpPkKwOVM4PzZ3PD;hQi=>
LT12 MoXnRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUTMd|ZDPDhiaILz NUOxe2s1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBz[XRiTGSxNkBk\WyuczDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDJR|UxKD1iMD6wOEDPxE1w NELDUIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
MDA-MB-231 MlPLRY51cWOjbnPldkBie3OjeR?= Ml7pOFghcHK| NV;Re|ZKSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFQzKM7:TT6= M1viTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOwN|U4Lz5{N{GzNFM2PzxxYU6=
L1210 M1fYWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVe0PEBpenN? MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFyxNlExKGOnbHzzJIJ6KFiWVDDhd5NigSCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlA2KM7:TT6= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
P388 NXHn[ZFqSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX3Lc3FOPDhiaILz Mly2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCjZILpZY16[2mwLYLld4l{fGGwdDDQN|g5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO|YYmsJGlEPTBiPTCwMlA2KM7:TT6= NGrBdoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
L12 NEnZOmdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnyyOFghcHK| MoPERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDyZZQhdXWudHnkdpVoNXKnc3nzeIFvfCCOMUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEWg{txONg>? NFzHNIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
L1210 M1;kTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4HSOFQ5KGi{cx?= MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKExzMkGwJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkC1JO69VS5? Mli5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3M{e3OlUoRjJyNUO3O|Y2RC:jPh?=
P388 NXzZW|EzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2W2UFQ5KGi{cx?= NX3je|JbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBCTFJvcnXzbZN1[W62IH3veZNmKFB|OEigZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEWg{txONg>? Mkj6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEWyNlMoRjJzN{C1NlI{RC:jPh?=
U2OS M1nKbmZ2dmO2aX;uJIF{e2G7 Ml6wO|IhcHK| M1S5cWlv\HWldHnvckBw\iCvaYTveIlkKGG{cnXzeEBqdiCqdX3hckBWOk:VIHPlcIx{KGG|c3Xzd4VlKGG|IH3peI91cWNiaX7k[Zgh[W[2ZYKgO|IhcHK|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwJF0hOC5yNTFOwG0v MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEi4O{c,OjR7MEC4PFc9N2F-
L1210 NH7VeGFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHfkOXM1QCCqcoO= NXrvXVdvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{Bi\nSncjC0PEBpenNiYomgXHRVKGG|c3H5MEBKSzVyIE2gNE4xPiEQvF2u NHHVUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
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BT-12 MnPCdWhVWyCjc4PhfS=> Ml\2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRnQuOTJiY3XscJM> M3zESVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5 M1rjXJFJXFNiYYPzZZk> M4DF[ZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{ NYHPd5RmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
DAOY MnnDdWhVWyCjc4PhfS=> MoTidWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgSGFQYSClZXzsdy=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
BT-37 MkTRdWhVWyCjc4PhfS=> NEPrbplyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1|NzDj[Yxtew>? NXGxOmRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
TC32 NXPPU2VUeUiWUzDhd5NigQ>? NHfTeWtyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBVSzN{IHPlcIx{ NXjFW3R2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63 (6-TG R) M1TjXJFJXFNiYYPzZZk> MX3xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDNS{A3OyBqNj3US{BTMSClZXzsdy=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
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RD MofRdWhVWyCjc4PhfS=> NF7hO|RyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBTTCClZXzsdy=> MnfEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Saos-2 NYnSOGZueUiWUzDhd5NigQ>? MmiwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV4Fwey1{IHPlcIx{ MmTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 Ml;tdWhVWyCjc4PhfS=> NUjNfGRKeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HeLa NX[0XVk1TnWwY4Tpc44h[XO|YYm= NWPEUI5SOjRiaILz MmXJTY5pcWKrdHnvckBw\iC2dXL1cIlvKHCxbInt[ZJqgmG2aX;uJIlvKGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd49tfWKuZTD0eYJ2dGmwIH\yZYN1cW:wIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDhzOEe2PEc,Ojh6MUi3Olg9N2F-
HeLa MojCSpVv[3Srb36gZZN{[Xl? M4HCO|AvOSC3TR?= NVPkeo5oOjRiaILz NHnWN4lKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDzbIlnfCCxZjD0eYJ2dGmwIIDyc5RmcW5idH:gd49tfWKuZTDmdoFkfGmxbjDheEAxNjFidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> M{\tdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUCxPVQxLz5{OUWwNVk1ODxxYU6=
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MCF7 MlnBSpVv[3Srb36gZZN{[Xl? Mm[4NUB2VQ>? MkfhOEBpenN? MnXjTY5lfWO2aX;uJI9nKHS3YoXsbY4h\GWyb3z5cYVzcXqjdHnvckBqdiCqdX3hckBOS0Z5IHPlcIx{KGG2IEGgeW0h[W[2ZYKgOEBpenNiYomgW4V{fGW{bjDicI91KG2ndHjv[C=> M{S2N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki5O|I5Lz5{N{[4PVczQDxxYU6=
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Assay
Methods Test Index PMID
Western blot Cdc2 / cyclin B1 / MAD2 / Cdc20 21918689
Immunofluorescence Brd4 / α-tubulin ; Tubulin / LC8 22567088 23038268
Growth inhibition assay Cell viability 21918689
In vivo The tumor volume and tumor weight of the mice treated with Ketoconazole  plus  Nocodazole are significantly reduced as compared with those treated with Ketoconazole or Nocodazole alone. Combined treatment with Ketoconazole  plus  Nocodazole strongly enhances apoptosis of COLO 205 tumor xenografts treated with Ketoconazole  or  Nocodazole alone. [5]

Protocol (from reference)

Animal Research:

[5]

  • Animal Models: Nude mice with COLO-205 tumor xenografts
  • Dosages: 5 mg/kg
  • Administration: Administered via i.p.

Solubility (25°C)

In vitro

DMSO 7 mg/mL
(23.23 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

1mg/mL

Chemical Information

Molecular Weight 301.32
Formula

C14H11N3O3S

CAS No. 31430-18-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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