Montelukast Sodium

For research use only.

Catalog No.S4211 Synonyms: MK-0476

5 publications

Montelukast Sodium Chemical Structure

CAS No. 151767-02-1

Montelukast (MK-0476) selectively antagonizes leukotriene D4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves macroautophagy but not the chaperone-mediated autophagy pathway. Precipitations may form after reconstitution,solution is best fresh-prepared.

Selleck's Montelukast Sodium has been cited by 5 publications

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Biological Activity

Description Montelukast (MK-0476) selectively antagonizes leukotriene D4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves macroautophagy but not the chaperone-mediated autophagy pathway. Precipitations may form after reconstitution,solution is best fresh-prepared.
Targets
CysLT1 [1]
In vitro

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NHzyZnBHfW6ldHnvckBie3OjeR?= NV;kT5dTOTBibXnudy=> NHvCVmpCdnSjZ3;ubZN1KGGldHn2bZR6KGGpYXnud5QhS3m|TGSxJJJm[2WydH;yJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzUSFQucW6mdXPl[EBk[WylaYXtJI1w[mmuaYrheIlwdiCycnWtbY5kfWKjdHXkJIZweiBzMDDtbY5{KGKnZn;y[UBNXER2IHHk[Il1cW:wIHL5JGZtfW9vNDDBUUBlgWViYnHz[YQh\my3b4LpcYV1emmlIHHzd4F6NCCLQ{WwQVAvOzIQvF2= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl6NUOyOUc,OjZ7OEWzNlU9N2F-
HEK293 NYTtW3JFTnWwY4Tpc44h[XO|YYm= MYSxNEBucW6| MVzBcpRi\2:waYP0JIFkfGm4aYT5JIFo[Wmwc4SgR5l{VFR{IILlZ4VxfG:{IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEyWREStbY5lfWOnZDDjZYxkcXWvIH3vZoltcXqjdHnvckBxemVvaX7jeYJifGWmIH\vdkAyOCCvaX7zJIJm\m:{ZTDMWGQ1KGGmZHn0bY9vKGK7IF\seY8uPCCDTTDkfYUh[mG|ZXSg[ox2d3KrbXX0dolkKGG|c3H5MEBKSzVyPUK3{txO NHTGd4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzPSd-Mk[5PFU{OjV:L3G+

... Click to View More Cell Line Experimental Data

In vivo Montelukast (6 mg/kg, once per day for 20 d) significantly suppresses the increased eosinophils in BAL fluid and lung tissue, and increases IL-5 level in BAL fluid in OVA challenged mice. OVA challenge increases CysLT1 but decreases CysLT2 receptor mRNA expression. Montelukast inhibits the increased CysLT1 but not the reduces CysLT2 expression after OVA challenge. [2]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.42 mM)
Water 100 mg/mL (164.42 mM)
Ethanol 100 mg/mL (164.42 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 608.17
Formula

C35H36ClNO3S.Na

CAS No. 151767-02-1
Storage 3 years -20°C powder
Synonyms MK-0476
Smiles CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)[O-])O.[Na+]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04351698 Not yet recruiting Drug: Montelukast|Other: Oral Placebo Anemia Sickle Cell|Sleep-Disordered Breathing Great Ormond Street Hospital for Children NHS Foundation Trust|Guy''s and St Thomas'' NHS Foundation Trust|University College London Hospitals|North Middlesex University Hospital|King''s College Hospital NHS Trust|The Whittington Hospital NHS Trust August 1 2021 Phase 2|Phase 3
NCT03545997 Terminated Drug: Montelukast 10mg|Drug: Placebo Sleep Apnea Obstructive University Hospital Grenoble|Act For Chronic Diseases|Direction Générale de l''Offre de Soins November 29 2019 Phase 3
NCT03991988 Recruiting Drug: Montelukast|Drug: Placebo oral tablet Alzheimer Disease Emory University September 25 2019 Phase 2
NCT03898193 Completed Drug: Montelukast|Drug: Singulair Healthy Adults Pharmtechnology LLC|ClinPharmInvest LLC March 23 2019 Phase 1
NCT03380975 Completed Drug: Montelukast 10mg Asthma and Allergic Rhinitis Clinision August 28 2018 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID