MG149

For research use only.

Catalog No.S7476 Synonyms: Tip60 HAT inhibitor

15 publications

MG149 Chemical Structure

CAS No. 1243583-85-8

MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.

Selleck's MG149 has been cited by 15 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
Targets
MOF [1]
(Cell-free assay)
Tip60 [1]
(Cell-free assay)
47 μM 74 μM
In vitro

MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) MnfMSpVv[3Srb36gZZN{[Xl? NFrnTGE2KG2rboO= MVfJcohq[mm2aX;uJI9nKGi3bXHuJG1QTiCneIDy[ZN{\WRiaX6gSZNkcGW{aXPobYEh[2:uaTDCUFIyMESHMzmgZ4VtdHNidYPpcochYzF2Q23BR{1Ed0FiYX7kJIhqe3SxbnWgTFQh[XNic4Xid5Rz[XSnIHHmeIVzKDVibXnud{BjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nMEBKSzVyIE2gOFch|ryPLh?= NEDMZYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNFE{Pyd-MkKxNFAyOzd:L3G+
SJ-GBM2 M2XjSJFJXFNiYYPzZZk> M4TxOpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSj3HRm0zKGOnbHzz MmLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MmHwdWhVWyCjc4PhfS=> NEjpdnVyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> MlvqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
HCT116 NHn5Z3pHfW6ldHnvckBie3OjeR?= NHzEepcyODBidV2= MlzrNVQh\GG7cx?= NF7QfIFKdmirYnn0bY9vKG:oIHPvcI9vgSCob4LtZZRqd25iaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIF1KDFyMDD1UUBi\nSncjCxOEBl[Xm|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5 NVn1VllbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOFU{PzNpPkOwNVQ2Ozd|PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 28202522     


MOLM13, NOMO1 and murine polyclonal MA9 cells were plated in liquid culture and treated with various concentrations of MG149. Plotted is the IC50 curve for cell viability as a percentage of the vehicle (DMSO) control at day three of treatment. Numbers indicate the IC50 per cell type (by color).

28202522

Protocol

Solubility (25°C)

In vitro DMSO 68 mg/mL (199.72 mM)
Water Insoluble
Ethanol '68 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.46
Formula

C22H28O3

CAS No. 1243583-85-8
Storage powder
in solvent
Synonyms Tip60 HAT inhibitor
Smiles CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histone Acetyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID