For research use only.

Catalog No.S7476 Synonyms: Tip60 HAT inhibitor

12 publications

MG149 Chemical Structure

CAS No. 1243583-85-8

MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.

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Selleck's MG149 has been cited by 12 publications

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Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
MOF [1]
(Cell-free assay)
Tip60 [1]
(Cell-free assay)
47 μM 74 μM
In vitro

MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) M4qwTGZ2dmO2aX;uJIF{e2G7 MlfVOUBucW6| NXrFO2dPUW6qaXLpeIlwdiCxZjDoeY1idiCPT1[g[ZhxemW|c3XkJIlvKEW|Y3jldolkcGmjIHPvcIkhSkx{MTjESVMqKGOnbHzzJJV{cW6pIGuxOGNeSUNvQ3;BJIFv\CCqaYP0c45mKEh2IHHzJJN2[nO2cnH0[UBi\nSncjC1JI1qdnNiYomgd4NqdnSrbHzheIlwdiClb4XueIlv\yxiSVO1NEA:KDR5IN88UU4> NEOxOYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNFE{Pyd-MkKxNFAyOzd:L3G+
SJ-GBM2 MXTxTHRUKGG|c3H5 NU\4doR3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM> MnLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC Mn\jdWhVWyCjc4PhfS=> NUHtR4JHeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM> MkLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
HCT116 NGS2cXpHfW6ldHnvckBie3OjeR?= NIrK[5EyODBidV2= MV:xOEBl[Xm| M1Pqc2lvcGmkaYTpc44hd2ZiY3;sc456KG[xcn3heIlwdiCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZQhOTByIIXNJIFnfGW{IEG0JIRigXNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYnHz[YQh[XO|YYm= NV7xNIlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOFU{PzNpPkOwNVQ2Ozd|PD;hQi=>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 28202522     

MOLM13, NOMO1 and murine polyclonal MA9 cells were plated in liquid culture and treated with various concentrations of MG149. Plotted is the IC50 curve for cell viability as a percentage of the vehicle (DMSO) control at day three of treatment. Numbers indicate the IC50 per cell type (by color).



Solubility (25°C)

In vitro DMSO 68 mg/mL (199.72 mM)
Water Insoluble
Ethanol '68 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.46


CAS No. 1243583-85-8
Storage powder
in solvent
Synonyms Tip60 HAT inhibitor

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Histone Acetyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID