MG149

Catalog No.S7476 Synonyms: Tip60 HAT inhibitor

For research use only.

MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.

MG149 Chemical Structure

CAS No. 1243583-85-8

Selleck's MG149 has been cited by 17 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
Targets
MOF [1]
(Cell-free assay)
Tip60 [1]
(Cell-free assay)
47 μM 74 μM
In vitro

MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) NIC4WotHfW6ldHnvckBie3OjeR?= NHu0V282KG2rboO= MleyTY5pcWKrdHnvckBw\iCqdX3hckBOV0ZiZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRmwzOSiGRUOpJINmdGy|IIXzbY5oKFtzNFPdRWMuS2:DIHHu[EBpcXO2b37lJGg1KGG|IIP1ZpN1emG2ZTDh[pRmeiB3IH3pcpMh[nlic3PpcpRqdGyjdHnvckBkd3WwdHnu[{whUUN3MDC9JFQ4KM7:TT6= NH7PbXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNFE{Pyd-MkKxNFAyOzd:L3G+
SJ-GBM2 NYWwTWZ5eUiWUzDhd5NigQ>? NVvkS|J{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM> MlXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC NFnBW29yUFSVIHHzd4F6 MmjCdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HCT116 M{Tqd2Z2dmO2aX;uJIF{e2G7 M1fs[VExOCC3TR?= MUSxOEBl[Xm| NWTKSZJYUW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYF1cW:wIHnuJIh2dWGwIFjDWFEyPiClZXzsd{BifCBzMECgeW0h[W[2ZYKgNVQh\GG7czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCjc4PhfS=> NFrFdHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG0OVM4Oyd-M{CxOFU{PzN:L3G+
Assay
Methods Test Index PMID
Growth inhibition assay Cell viability 28202522

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 340.46
Formula

C22H28O3

CAS No. 1243583-85-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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