Home Apoptosis Bcl-2 inhibitor MIK665 (S64315) For research use only.

MIK665 (S64315)

MIK665 (S64315) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.

MIK665 (S64315) Chemical Structure

MIK665 (S64315) Chemical Structure

CAS: 1799631-75-6

Selleck's MIK665 (S64315) has been cited by 7 publications

Purity & Quality Control

Batch: Purity: 99.88%
99.88

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Signaling Pathway

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Biological Activity

Description MIK665 (S64315) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.
Targets
Mcl-1 [1]
(Cell-free assay)
1.2 nM(Ki)
In vitro
In vitro

S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1. [2]
Cell Research Cell lines H929 cells
Concentrations 26 pM (Ki)
Incubation Time 6 h
Method

H929 cells were treated for 6 h with increasing concentration of S64315.
In Vivo
In vivo

S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1. [2]
Animal Research Animal Models Female CB-17 SCID mice
Dosages 12.5 mg/kg
Administration i.v.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04702425 Active not recruiting
Non-Hodgkin Lymphoma (NHL)|Acute Myeloid Leukemia (AML)|Multiple Myeloma (MM)
Novartis Pharmaceuticals|Novartis
 June 23 2021 Phase 1
NCT04629443 Active not recruiting
Acute Myeloid Leukaemia
Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier
 February 17 2021 Phase 1|Phase 2
NCT02992483 Completed
Multiple Myeloma (MM) Lymphoma Large B-Cell Diffuse (DLBCL) Lymphoma
Novartis Pharmaceuticals|Novartis
 July 12 2017 Phase 1
NCT02979366 Completed
Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS)
Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier
 March 15 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 875.41 Formula

C47H44ClFN6O6S
CAS No. 1799631-75-6 SDF --
Smiles CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)OC(CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7OC)C(=O)O)C8=CC=C(C=C8)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (114.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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