S64315 (MIK665)

Catalog No.S8836

For research use only.

S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.

S64315 (MIK665) Chemical Structure

CAS No. 1799631-75-6

Selleck's S64315 (MIK665) has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.
Targets
Mcl-1 [1]
(Cell-free assay)
1.2 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 875.41
Formula

C47H44ClFN6O6S

CAS No. 1799631-75-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)OC(CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7OC)C(=O)O)C8=CC=C(C=C8)F

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04702425 Recruiting Drug: VOB560|Drug: MIK665 Non-Hodgkin Lymphoma (NHL)|Acute Myeloid Leukemia (AML)|Multiple Myeloma (MM) Novartis Pharmaceuticals|Novartis June 23 2021 Phase 1
NCT04629443 Recruiting Drug: S 64315 (also referred as MIK665) and azacitidine Acute Myeloid Leukaemia Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier February 17 2021 Phase 1|Phase 2
NCT02992483 Completed Drug: MIK665 Multiple Myeloma (MM) Lymphoma Large B-Cell Diffuse (DLBCL) Lymphoma Novartis Pharmaceuticals|Novartis July 12 2017 Phase 1
NCT02979366 Completed Drug: S64315 once a week|Drug: S64315 twice a week Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS) Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier March 15 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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