S64315 (MIK665)

For research use only.

Catalog No.S8836

3 publications

S64315 (MIK665) Chemical Structure

CAS No. 1799631-75-6

S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.

Selleck's S64315 (MIK665) has been cited by 3 publications

Purity & Quality Control

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Biological Activity

Description S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.
Targets
Mcl-1 [1]
(Cell-free assay)
1.2 nM(Ki)

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (114.23 mM)
Water Insoluble
Ethanol ''-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 875.41
Formula

C47H44ClFN6O6S

CAS No. 1799631-75-6
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)OC(CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7OC)C(=O)O)C8=CC=C(C=C8)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04702425 Recruiting Drug: VOB560|Drug: MIK665 Non-Hodgkin Lymphoma (NHL)|Acute Myeloid Leukemia (AML)|Multiple Myeloma (MM) Novartis Pharmaceuticals|Novartis June 23 2021 Phase 1
NCT04629443 Recruiting Drug: S 64315 (also referred as MIK665) and azacitidine Acute Myeloid Leukaemia Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier February 17 2021 Phase 1|Phase 2
NCT02992483 Completed Drug: MIK665 Multiple Myeloma (MM) Lymphoma Large B-Cell Diffuse (DLBCL) Lymphoma Novartis Pharmaceuticals|Novartis July 12 2017 Phase 1
NCT02979366 Completed Drug: S64315 once a week|Drug: S64315 twice a week Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS) Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier March 15 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID